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Anthony Portale, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPediatrics
Address550 16th. Street
San Francisco CA 94158
Phone415-476-1065
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Disordered Mineral Metabolism in the CKiD Children: Role of FGF-23
    NIH/NIDDK R01DK084978Jul 15, 2010 - Jun 30, 2014
    Role: Principal Investigator
    MOLECULAR REGULATION OF 1,25(OH)2D PRODUCTION
    NIH/NIDDK R01DK054433Aug 1, 1998 - Jul 31, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Altemose KE, Kumar J, Portale A, Warady BA, Furth SL, Fadrowski JJ, Atkinson MA. Vitamin D insufficiency, hemoglobin, and anemia in children with chronic kidney disease. Pediatr Nephrol. 2018 Jul 14. PMID: 30008129.
      View in: PubMed
    2. Insogna KL, Briot K, Imel EA, Kamenický P, Ruppe MD, Portale A, Weber T, Pitukcheewanont P, Cheong HI, Jan de Beur S, Imanishi Y, Ito N, Lachmann RH, Tanaka H, Perwad F, Zhang L, Chen CY, Theodore-Oklota C, Mealiffe M, San Martin J, Carpenter TO. A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. J Bone Miner Res. 2018 Jun 26. PMID: 29947083.
      View in: PubMed
    3. Sgambat K, Roem J, Mitsnefes M, Portale A, Furth S, Warady B, Moudgil A. Waist-to-height ratio, body mass index, and cardiovascular risk profile in children with chronic kidney disease. Pediatr Nephrol. 2018 Jun 05. PMID: 29872963.
      View in: PubMed
    4. Carpenter TO, Whyte MP, Imel EA, Boot AM, Högler W, Linglart A, Padidela R, Van't Hoff W, Mao M, Chen CY, Skrinar A, Kakkis E, San Martin J, Portale A. Burosumab Therapy in Children with X-Linked Hypophosphatemia. N Engl J Med. 2018 05 24; 378(21):1987-1998. PMID: 29791829.
      View in: PubMed
    5. Ng DK, Portale A, Furth SL, Warady BA, Muñoz A. Time-varying coefficient of determination to quantify the explanatory power of biomarkers on longitudinal GFR among children with chronic kidney disease. Ann Epidemiol. 2018 May 17. PMID: 29887227.
      View in: PubMed
    6. Carpenter TO, Shaw NJ, Portale A, Ward LM, Abrams SA, Pettifor JM. Rickets. Nat Rev Dis Primers. 2017 Dec 21; 3:17101. PMID: 29265106.
      View in: PubMed
    7. Mitsnefes MM, Betoko A, Schneider MF, Salusky IB, Wolf MS, Jüppner H, Warady BA, Furth SL, Portale A. FGF23 and Left Ventricular Hypertrophy in Children with CKD. Clin J Am Soc Nephrol. 2018 Jan 06; 13(1):45-52. PMID: 29025789.
      View in: PubMed
    8. Portale A, Wolf MS, Messinger S, Perwad F, Jüppner H, Warady BA, Furth SL, Salusky IB. Fibroblast Growth Factor 23 and Risk of CKD Progression in Children. Clin J Am Soc Nephrol. 2016 Nov 07; 11(11):1989-1998. PMID: 27561289.
      View in: PubMed
    9. Ruppe MD, Zhang X, Imel EA, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale A, Insogna K, Peacock M, Carpenter TO. Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia. Bone Rep. 2016 Dec; 5:158-162. PMID: 28326356.
      View in: PubMed
    10. Portale A, Zhang MY, David V, Martin A, Jiao Y, Gu W, Perwad F. Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule. PLoS One. 2015; 10(11):e0142924. PMID: 26588476; PMCID: PMC4654537.
    11. Kumar J, McDermott K, Abraham AG, Friedman LA, Johnson VL, Kaskel FJ, Furth SL, Warady BA, Portale A, Melamed ML. Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort. Pediatr Nephrol. 2016 Jan; 31(1):121-9. PMID: 26307635; PMCID: PMC4884450.
    12. Zhang X, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey J, Glorieux FH, Portale A, Insogna K, Carpenter TO, Peacock M. Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia. J Clin Pharmacol. 2016 Feb; 56(2):176-85. PMID: 26073451.
      View in: PubMed
    13. Denburg MR, Kumar J, Jemielita T, Brooks ER, Skversky A, Portale A, Salusky IB, Warady BA, Furth SL, Leonard MB. Fracture Burden and Risk Factors in Childhood CKD: Results from the CKiD Cohort Study. J Am Soc Nephrol. 2016 Feb; 27(2):543-50. PMID: 26139439; PMCID: PMC4731126 [Available on 02/01/17].
    14. Ku E, Glidden DV, Hsu CY, Portale A, Grimes B, Johansen KL. Association of Body Mass Index with Patient-Centered Outcomes in Children with ESRD. J Am Soc Nephrol. 2016 Feb; 27(2):551-8. PMID: 26054540; PMCID: PMC4731123 [Available on 02/01/17].
    15. Imel EA, Zhang X, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale A, Insogna K, Peacock M, Carpenter TO. Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23. J Clin Endocrinol Metab. 2015 Jul; 100(7):2565-73. PMID: 25919461; PMCID: PMC4495171.
    16. Ku E, Johansen KL, Portale A, Grimes B, Hsu CY. State level variations in nephrology workforce and timing and incidence of dialysis in the United States among children and adults: a retrospective cohort study. BMC Nephrol. 2015 Jan 15; 16:2. PMID: 25589150; PMCID: PMC4361136.
    17. Wassner SJ, Chesney RW, Friedman A, Chantler C, Portale A. Malcolm A. Holliday, M.D, January 12, 1924 - March 26, 2014. Pediatr Nephrol. 2014 Aug; 29(8):1473-4. PMID: 24817341.
      View in: PubMed
    18. Akber A, Portale A, Johansen KL. Use of pedometers to increase physical activity among children and adolescents with chronic kidney disease. Pediatr Nephrol. 2014 Aug; 29(8):1395-402. PMID: 24648129; PMCID: PMC4074553.
    19. Portale A, Wolf M, Jüppner H, Messinger S, Kumar J, Wesseling-Perry K, Schwartz GJ, Furth SL, Warady BA, Salusky IB. Disordered FGF23 and mineral metabolism in children with CKD. Clin J Am Soc Nephrol. 2014 Feb; 9(2):344-53. PMID: 24311704; PMCID: PMC3913243.
    20. Chanakul A, Zhang MY, Louw A, Armbrecht HJ, Miller WL, Portale A, Perwad F. FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues. PLoS One. 2013; 8(9):e72816. PMID: 24019880; PMCID: PMC3760837.
    21. Park-Sigal J, Don BR, Porzig A, Recker R, Griswold V, Sebastian A, Duh QY, Portale A, Shoback D, Schambelan M. Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone. J Bone Miner Res. 2013 Mar; 28(3):700-8. PMID: 23074096.
      View in: PubMed
    22. Chaudhuri A, Ozawa M, Everly MJ, Ettenger R, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Li L, Sigdel TK, Hsieh SC, Dai H, Naesens M, Waskerwitz J, Salvatierra O, Terasaki PI, Sarwal MM. The clinical impact of humoral immunity in pediatric renal transplantation. J Am Soc Nephrol. 2013 Mar; 24(4):655-64. PMID: 23449533; PMCID: PMC3609135.
    23. Akber A, Portale A, Johansen KL. Pedometer-assessed physical activity in children and young adults with CKD. Clin J Am Soc Nephrol. 2012 May; 7(5):720-6. PMID: 22422539; PMCID: PMC3338276.
    24. Zhang MY, Ranch D, Pereira RC, Armbrecht HJ, Portale A, Perwad F. Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice. Endocrinology. 2012 Apr; 153(4):1806-16. PMID: 22334725; PMCID: PMC3320256.
    25. Perwad F, Portale A. Vitamin D metabolism in the kidney: regulation by phosphorus and fibroblast growth factor 23. Mol Cell Endocrinol. 2011 Dec 05; 347(1-2):17-24. PMID: 21914460.
      View in: PubMed
    26. Ranch D, Zhang MY, Portale A, Perwad F. Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice. J Bone Miner Res. 2011 Aug; 26(8):1883-90. PMID: 21472778; PMCID: PMC4409871.
    27. McKay CP, Portale A. Emerging topics in pediatric bone and mineral disorders 2008. Semin Nephrol. 2009 Jul; 29(4):370-8. PMID: 19615558.
      View in: PubMed
    28. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008 Jan; 121(1):37-45. PMID: 18166555; PMCID: PMC3722048.
    29. Perwad F, Zhang MY, Tenenhouse HS, Portale A. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1577-83. PMID: 17699549.
      View in: PubMed
    30. Kim CJ, Kaplan LE, Perwad F, Huang N, Sharma A, Choi Y, Miller WL, Portale A. Vitamin D 1alpha-hydroxylase gene mutations in patients with 1alpha-hydroxylase deficiency. J Clin Endocrinol Metab. 2007 Aug; 92(8):3177-82. PMID: 17488797.
      View in: PubMed
    31. Antoniucci DM, Yamashita T, Portale A. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocrinol Metab. 2006 Aug; 91(8):3144-9. PMID: 16735491.
      View in: PubMed
    32. Matsuda-Abedini M, Portale A, Shah A, Neuhaus J, McEnhill M, Mathias RS. Persistent secondary hyperparathyroidism after renal transplantation in children. Pediatr Nephrol. 2006 Mar; 21(3):413-8. PMID: 16385389.
      View in: PubMed
    33. Perwad F, Azam N, Zhang MY, Yamashita T, Tenenhouse HS, Portale A. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology. 2005 Dec; 146(12):5358-64. PMID: 16123154.
      View in: PubMed
    34. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale A, Miller WL, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 05; 352(18):1884-90. PMID: 15872203.
      View in: PubMed
    35. Azam N, Zhang MY, Wang X, Tenenhouse HS, Portale A. Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice. Endocrinology. 2003 Aug; 144(8):3463-8. PMID: 12865326.
      View in: PubMed
    36. Miller WL, Portale A. Vitamin D biosynthesis and vitamin D 1 alpha-hydroxylase deficiency. Endocr Dev. 2003; 6:156-74. PMID: 12964431.
      View in: PubMed
    37. Wang X, Zhang MY, Miller WL, Portale A. Novel gene mutations in patients with 1alpha-hydroxylase deficiency that confer partial enzyme activity in vitro. J Clin Endocrinol Metab. 2002 Jun; 87(6):2424-30. PMID: 12050193.
      View in: PubMed
    38. Xie Z, Munson SJ, Huang N, Portale A, Miller WL, Bikle DD. The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J Biol Chem. 2002 Oct 04; 277(40):36987-90. PMID: 11956203.
      View in: PubMed
    39. Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale A. Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule. Endocrinology. 2002 Feb; 143(2):587-95. PMID: 11796514.
      View in: PubMed
    40. Farine D, Jackson U, Portale A, Baxi L, Fox HE. Pregnancy complicated by maternal spina bifida. A report of two cases. J Reprod Med. 1988 Mar; 33(3):323-6. PMID: 3283355.
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    41. Powell D, Pond SM, Allen TB, Portale A. Hemoperfusion in a child who ingested diquat and died from pontine infarction and hemorrhage. J Toxicol Clin Toxicol. 1983 Jul; 20(5):405-20. PMID: 6668627.
      View in: PubMed
    42. Galvagna S, Rosella PP, Portale A. [Clinical study of the effects of metisoprinol in the treatment of mumps in adults]. Clin Ter. 1980 Dec 31; 95(6):681-5. PMID: 6163586.
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