Anthony Portale, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street, #4344
San Francisco CA 94158
Phone415-476-2423
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Disordered Mineral Metabolism in the CKiD Children: Role of FGF-23
    NIH R01DK084978Jul 15, 2010 - Jun 30, 2016
    Role: Principal Investigator
    MOLECULAR REGULATION OF 1,25(OH)2D PRODUCTION
    NIH R01DK054433Aug 1, 1998 - Jul 31, 2005
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Burosumab vs conventional therapy in children with X-linked hypophosphatemia: results of the open-label, phase 3 extension period. JBMR Plus. 2024 Jan; 8(1):ziad001. Ward LM, Högler W, Glorieux FH, Portale AA, Whyte MP, Munns CF, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Sochett E, Muroya K, Tanaka H, Pitukcheewanont P, Gottesman GS, Biggin A, Perwad F, Chen A, Lawrence Merritt Ii J, Imel EA. PMID: 38690124; PMCID: PMC11059996.
      View in: PubMed   Mentions: Translation:CTClinical Trials
    2. Burosumab vs Phosphate/Active Vitamin D in Pediatric X-Linked Hypophosphatemia: A Subgroup Analysis by Dose Level. J Clin Endocrinol Metab. 2023 10 18; 108(11):2990-2998. Imel EA, Glorieux FH, Whyte MP, Portale AA, Munns CF, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Chen A, Roberts MS, Ward LM. PMID: 37084401; PMCID: PMC10583998.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Long-term Burosumab Administration Is Safe and Effective in Adults With X-linked Hypophosphatemia. J Clin Endocrinol Metab. 2022 12 17; 108(1):155-165. Weber TJ, Imel EA, Carpenter TO, Peacock M, Portale AA, Hetzer J, Merritt JL, Insogna K. PMID: 36072994; PMCID: PMC9759172.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    4. Efficacy of Burosumab in Adults with X-linked Hypophosphatemia (XLH): A Post Hoc Subgroup Analysis of a Randomized Double-Blind Placebo-Controlled Phase 3 Study. Calcif Tissue Int. 2022 10; 111(4):409-418. Brandi ML, Jan de Beur S, Briot K, Carpenter T, Cheong HI, Cohen-Solal M, Crowley RK, Eastell R, Imanishi Y, Imel EA, Ing SW, Insogna K, Ito N, Javaid K, Kamenicky P, Keen R, Kubota T, Lachmann RH, Perwad F, Pitukcheewanont P, Portale A, Ralston SH, Tanaka H, Weber TJ, Yoo HW, Sun W, Williams A, Nixon A, Takeuchi Y. PMID: 35927518.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    5. Effect of Burosumab Compared With Conventional Therapy on Younger vs Older Children With X-linked Hypophosphatemia. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3241-e3253. Ward LM, Glorieux FH, Whyte MP, Munns CF, Portale AA, Högler W, Simmons JH, Gottesman GS, Padidela R, Namba N, Cheong HI, Nilsson O, Mao M, Chen A, Skrinar A, Roberts MS, Imel EA. PMID: 35533340; PMCID: PMC9282253.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    6. A review of ferric citrate clinical studies, and the rationale and design of the Ferric Citrate and Chronic Kidney Disease in Children (FIT4KiD) trial. Pediatr Nephrol. 2022 11; 37(11):2547-2557. Hanudel MR, Laster ML, Portale AA, Dokras A, Quigley RP, Guzman GAL, Zaritsky JJ, Hayde NA, Kaskel FJ, Mitsnefes MM, Ramirez JA, Imani PD, Srivaths PR, Kogon AJ, Denburg MR, Blydt-Hansen TD, Reyes LZ, Greenbaum LA, Weidemann DK, Warady BA, Elashoff DA, Mendley SR, Isakova T, Salusky IB. PMID: 35237863; PMCID: PMC9437144.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia. J Clin Endocrinol Metab. 2022 02 17; 107(3):813-824. Linglart A, Imel EA, Whyte MP, Portale AA, Högler W, Boot AM, Padidela R, Van't Hoff W, Gottesman GS, Chen A, Skrinar A, Scott Roberts M, Carpenter TO. PMID: 34636899; PMCID: PMC8851952.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    8. Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension. RMD Open. 2021 09; 7(3). Briot K, Portale AA, Brandi ML, Carpenter TO, Cheong HI, Cohen-Solal M, Crowley RK, Eastell R, Imanishi Y, Ing S, Insogna K, Ito N, Jan de Beur S, Javaid MK, Kamenicky P, Keen R, Kubota T, Lachmann RH, Perwad F, Pitukcheewanont P, Ralston SH, Takeuchi Y, Tanaka H, Weber TJ, Yoo HW, Nixon A, Nixon M, Sun W, Williams A, Imel EA. PMID: 34548383; PMCID: PMC8458321.
      View in: PubMed   Mentions: 9  Translation:HumansCTClinical Trials
    9. Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia. Calcif Tissue Int. 2021 05; 108(5):622-633. Padidela R, Whyte MP, Glorieux FH, Munns CF, Ward LM, Nilsson O, Portale AA, Simmons JH, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Williams A, Nixon A, Sun W, Chen A, Skrinar A, Imel EA. PMID: 33484279; PMCID: PMC8064984.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    10. Association Between Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study. Kidney Med. 2020 Jul-Aug; 2(4):398-406. Yokoyama JS, Matsuda-Abedini M, Denburg MR, Kumar J, Warady BA, Furth SL, Hooper SR, Portale AA, Perwad F. PMID: 32775979; PMCID: PMC7406846.
      View in: PubMed   Mentions: 7  
    11. Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial. J Bone Miner Res. 2019 12; 34(12):2183-2191. Insogna KL, Rauch F, Kamenický P, Ito N, Kubota T, Nakamura A, Zhang L, Mealiffe M, San Martin J, Portale AA. PMID: 31369697; PMCID: PMC6916280.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCTClinical Trials
    12. Burosumab Therapy for X-Linked Hypophosphatemia and Therapeutic Implications for CKD. Clin J Am Soc Nephrol. 2019 07 05; 14(7):1097-1099. Perwad F, Portale AA. PMID: 31171590; PMCID: PMC6625611.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    13. Continued Beneficial Effects of Burosumab in Adults with X-Linked Hypophosphatemia: Results from a 24-Week Treatment Continuation Period After a 24-Week Double-Blind Placebo-Controlled Period. Calcif Tissue Int. 2019 Sep; 105(3):271-284. Portale AA, Carpenter TO, Brandi ML, Briot K, Cheong HI, Cohen-Solal M, Crowley R, Jan De Beur S, Eastell R, Imanishi Y, Imel EA, Ing S, Ito N, Javaid M, Kamenicky P, Keen R, Kubota T, Lachmann R, Perwad F, Pitukcheewanont P, Ralston SH, Takeuchi Y, Tanaka H, Weber TJ, Yoo HW, Zhang L, Theodore-Oklota C, Mealiffe M, San Martin J, Insogna K. PMID: 31165191.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCTClinical Trials
    14. Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial. Lancet. 2019 06 15; 393(10189):2416-2427. Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA. PMID: 31104833; PMCID: PMC7179969.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCTClinical Trials
    15. Correction to: An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis. Pediatr Nephrol. 2019 Apr; 34(4):739-740. Sohn WY, Portale AA, Salusky IB, Zhang H, Yan LL, Ertik B, Shahinfar S, Lee E, Dehmel B, Warady BA. PMID: 30536181; PMCID: PMC6828146.
      View in: PubMed   Mentions:    Fields:    
    16. An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis. Pediatr Nephrol. 2019 01; 34(1):145-154. Sohn WY, Portale AA, Salusky IB, Zhang H, Yan LL, Ertik B, Shahinfar S, Lee E, Dehmel B, Warady BA. PMID: 30141180; PMCID: PMC6244811.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    17. Vitamin D insufficiency, hemoglobin, and anemia in children with chronic kidney disease. Pediatr Nephrol. 2018 11; 33(11):2131-2136. Altemose KE, Kumar J, Portale AA, Warady BA, Furth SL, Fadrowski JJ, Atkinson MA. PMID: 30008129; PMCID: PMC6528819.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis. J Bone Miner Res. 2018 08; 33(8):1383-1393. Insogna KL, Briot K, Imel EA, Kamenický P, Ruppe MD, Portale AA, Weber T, Pitukcheewanont P, Cheong HI, Jan de Beur S, Imanishi Y, Ito N, Lachmann RH, Tanaka H, Perwad F, Zhang L, Chen CY, Theodore-Oklota C, Mealiffe M, San Martin J, Carpenter TO, AXLES 1 Investigators. PMID: 29947083.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCTClinical Trials
    19. Waist-to-height ratio, body mass index, and cardiovascular risk profile in children with chronic kidney disease. Pediatr Nephrol. 2018 09; 33(9):1577-1583. Sgambat K, Roem J, Mitsnefes M, Portale AA, Furth S, Warady B, Moudgil A. PMID: 29872963; PMCID: PMC6281775.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. Burosumab Therapy in Children with X-Linked Hypophosphatemia. N Engl J Med. 2018 05 24; 378(21):1987-1998. Carpenter TO, Whyte MP, Imel EA, Boot AM, Högler W, Linglart A, Padidela R, Van't Hoff W, Mao M, Chen CY, Skrinar A, Kakkis E, San Martin J, Portale AA. PMID: 29791829.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansCTClinical Trials
    21. Time-varying coefficient of determination to quantify the explanatory power of biomarkers on longitudinal GFR among children with chronic kidney disease. Ann Epidemiol. 2018 08; 28(8):549-556. Ng DK, Portale AA, Furth SL, Warady BA, Muñoz A. PMID: 29887227; PMCID: PMC6205223.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. Rickets. Nat Rev Dis Primers. 2017 Dec 21; 3:17101. Carpenter TO, Shaw NJ, Portale AA, Ward LM, Abrams SA, Pettifor JM. PMID: 29265106.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    23. FGF23 and Left Ventricular Hypertrophy in Children with CKD. Clin J Am Soc Nephrol. 2018 01 06; 13(1):45-52. Mitsnefes MM, Betoko A, Schneider MF, Salusky IB, Wolf MS, Jüppner H, Warady BA, Furth SL, Portale AA. PMID: 29025789; PMCID: PMC5753303.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    24. Fibroblast Growth Factor 23 and Risk of CKD Progression in Children. Clin J Am Soc Nephrol. 2016 11 07; 11(11):1989-1998. Portale AA, Wolf MS, Messinger S, Perwad F, Jüppner H, Warady BA, Furth SL, Salusky IB. PMID: 27561289; PMCID: PMC5108188.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    25. Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia. Bone Rep. 2016 Dec; 5:158-162. Ruppe MD, Zhang X, Imel EA, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale AA, Insogna K, Peacock M, Carpenter TO. PMID: 28326356; PMCID: PMC4926842.
      View in: PubMed   Mentions: 22  
    26. Effect of Immigration Status on Outcomes in Pediatric Kidney Transplant Recipients. Am J Transplant. 2016 06; 16(6):1827-33. McEnhill ME, Brennan JL, Winnicki E, Lee MM, Tavakol M, Posselt AM, Stock PG, Portale AA. PMID: 26699829.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule. PLoS One. 2015; 10(11):e0142924. Portale AA, Zhang MY, David V, Martin A, Jiao Y, Gu W, Perwad F. PMID: 26588476; PMCID: PMC4654537.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort. Pediatr Nephrol. 2016 Jan; 31(1):121-9. Kumar J, McDermott K, Abraham AG, Friedman LA, Johnson VL, Kaskel FJ, Furth SL, Warady BA, Portale AA, Melamed ML. PMID: 26307635; PMCID: PMC4884450.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    29. Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia. J Clin Pharmacol. 2016 Feb; 56(2):176-85. Zhang X, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey J, Glorieux FH, Portale AA, Insogna K, Carpenter TO, Peacock M. PMID: 26073451; PMCID: PMC5042055.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    30. Fracture Burden and Risk Factors in Childhood CKD: Results from the CKiD Cohort Study. J Am Soc Nephrol. 2016 Feb; 27(2):543-50. Denburg MR, Kumar J, Jemielita T, Brooks ER, Skversky A, Portale AA, Salusky IB, Warady BA, Furth SL, Leonard MB. PMID: 26139439; PMCID: PMC4731126.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    31. Association of Body Mass Index with Patient-Centered Outcomes in Children with ESRD. J Am Soc Nephrol. 2016 Feb; 27(2):551-8. Ku E, Glidden DV, Hsu CY, Portale AA, Grimes B, Johansen KL. PMID: 26054540; PMCID: PMC4731123.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    32. Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23. J Clin Endocrinol Metab. 2015 Jul; 100(7):2565-73. Imel EA, Zhang X, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale AA, Insogna K, Peacock M, Carpenter TO. PMID: 25919461; PMCID: PMC4495171.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCTClinical Trials
    33. State level variations in nephrology workforce and timing and incidence of dialysis in the United States among children and adults: a retrospective cohort study. BMC Nephrol. 2015 Jan 15; 16:2. Ku E, Johansen KL, Portale AA, Grimes B, Hsu CY. PMID: 25589150; PMCID: PMC4361136.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    34. Malcolm A. Holliday, M.D, January 12, 1924 - March 26, 2014. Pediatr Nephrol. 2014 Aug; 29(8):1473-4. Wassner SJ, Chesney RW, Friedman A, Chantler C, Portale AA. PMID: 24817341.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Use of pedometers to increase physical activity among children and adolescents with chronic kidney disease. Pediatr Nephrol. 2014 Aug; 29(8):1395-402. Akber A, Portale AA, Johansen KL. PMID: 24648129; PMCID: PMC4074553.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. Disordered FGF23 and mineral metabolism in children with CKD. Clin J Am Soc Nephrol. 2014 Feb; 9(2):344-53. Portale AA, Wolf M, Jüppner H, Messinger S, Kumar J, Wesseling-Perry K, Schwartz GJ, Furth SL, Warady BA, Salusky IB. PMID: 24311704; PMCID: PMC3913243.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    37. FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues. PLoS One. 2013; 8(9):e72816. Chanakul A, Zhang MY, Louw A, Armbrecht HJ, Miller WL, Portale AA, Perwad F. PMID: 24019880; PMCID: PMC3760837.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    38. Combined pancreatic islet and kidney transplantation in a child with unstable type 1 diabetes and end-stage renal disease. Am J Transplant. 2013 Aug; 13(8):2207-10. Benedict KA, Moassesfar S, Adi S, Gitelman SE, Brennan JL, McEnhill M, Stock PG, Portale AA, Posselt AM. PMID: 23763601; PMCID: PMC4063279.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone. J Bone Miner Res. 2013 Mar; 28(3):700-8. Park-Sigal J, Don BR, Porzig A, Recker R, Griswold V, Sebastian A, Duh QY, Portale AA, Shoback D, Schambelan M. PMID: 23074096.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. The clinical impact of humoral immunity in pediatric renal transplantation. J Am Soc Nephrol. 2013 Mar; 24(4):655-64. Chaudhuri A, Ozawa M, Everly MJ, Ettenger R, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Li L, Sigdel TK, Hsieh SC, Dai H, Naesens M, Waskerwitz J, Salvatierra O, Terasaki PI, Sarwal MM. PMID: 23449533; PMCID: PMC3609135.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    41. A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant. 2012 Oct; 12(10):2710-8. Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, Chen A, Hsieh S, Dai H, Zhang M, Naesens M, Zarkhin V, Sansanwal P, Chen R, Mindrinos M, Xiao W, Benfield M, Ettenger RB, Dharnidharka V, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Davis R, Butte AJ, Salvatierra O, Sarwal MM. PMID: 23009139; PMCID: PMC4148014.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    42. Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up. Am J Transplant. 2012 Oct; 12(10):2719-29. Sarwal MM, Ettenger RB, Dharnidharka V, Benfield M, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Tang L, Liu J, Li L, Naesens M, Sigdel T, Waskerwitz J, Salvatierra O. PMID: 22694755; PMCID: PMC3681527.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    43. Pedometer-assessed physical activity in children and young adults with CKD. Clin J Am Soc Nephrol. 2012 May; 7(5):720-6. Akber A, Portale AA, Johansen KL. PMID: 22422539; PMCID: PMC3338276.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    44. Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice. Endocrinology. 2012 Apr; 153(4):1806-16. Zhang MY, Ranch D, Pereira RC, Armbrecht HJ, Portale AA, Perwad F. PMID: 22334725; PMCID: PMC3320256.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    45. Vitamin D metabolism in the kidney: regulation by phosphorus and fibroblast growth factor 23. Mol Cell Endocrinol. 2011 Dec 05; 347(1-2):17-24. Perwad F, Portale AA. PMID: 21914460.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    46. Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice. J Bone Miner Res. 2011 Aug; 26(8):1883-90. Ranch D, Zhang MY, Portale AA, Perwad F. PMID: 21472778; PMCID: PMC4409871.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    47. Emerging topics in pediatric bone and mineral disorders 2008. Semin Nephrol. 2009 Jul; 29(4):370-8. McKay CP, Portale A. PMID: 19615558.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    48. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008 Jan; 121(1):37-45. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. PMID: 18166555; PMCID: PMC3722048.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    49. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1577-83. Perwad F, Zhang MY, Tenenhouse HS, Portale AA. PMID: 17699549.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    50. Vitamin D 1alpha-hydroxylase gene mutations in patients with 1alpha-hydroxylase deficiency. J Clin Endocrinol Metab. 2007 Aug; 92(8):3177-82. Kim CJ, Kaplan LE, Perwad F, Huang N, Sharma A, Choi Y, Miller WL, Portale AA. PMID: 17488797.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    51. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocrinol Metab. 2006 Aug; 91(8):3144-9. Antoniucci DM, Yamashita T, Portale AA. PMID: 16735491.
      View in: PubMed   Mentions: 176     Fields:    Translation:Humans
    52. Persistent secondary hyperparathyroidism after renal transplantation in children. Pediatr Nephrol. 2006 Mar; 21(3):413-8. Matsuda-Abedini M, Portale AA, Shah A, Neuhaus J, McEnhill M, Mathias RS. PMID: 16385389.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    53. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology. 2005 Dec; 146(12):5358-64. Perwad F, Azam N, Zhang MY, Yamashita T, Tenenhouse HS, Portale AA. PMID: 16123154.
      View in: PubMed   Mentions: 163     Fields:    Translation:Animals
    54. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 05; 352(18):1884-90. Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. PMID: 15872203; PMCID: PMC5340184.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    55. Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice. Endocrinology. 2003 Aug; 144(8):3463-8. Azam N, Zhang MY, Wang X, Tenenhouse HS, Portale AA. PMID: 12865326.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    56. Vitamin D biosynthesis and vitamin D 1 alpha-hydroxylase deficiency. Endocr Dev. 2003; 6:156-74. Miller WL, Portale AA. PMID: 12964431.
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    57. Novel gene mutations in patients with 1alpha-hydroxylase deficiency that confer partial enzyme activity in vitro. J Clin Endocrinol Metab. 2002 Jun; 87(6):2424-30. Wang X, Zhang MY, Miller WL, Portale AA. PMID: 12050193.
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    58. The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes. J Biol Chem. 2002 Oct 04; 277(40):36987-90. Xie Z, Munson SJ, Huang N, Portale AA, Miller WL, Bikle DD. PMID: 11956203.
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    59. Dietary phosphorus transcriptionally regulates 25-hydroxyvitamin D-1alpha-hydroxylase gene expression in the proximal renal tubule. Endocrinology. 2002 Feb; 143(2):587-95. Zhang MY, Wang X, Wang JT, Compagnone NA, Mellon SH, Olson JL, Tenenhouse HS, Miller WL, Portale AA. PMID: 11796514.
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    60. Renal expression of the sodium/phosphate cotransporter gene, Npt2, is not required for regulation of renal 1 alpha-hydroxylase by phosphate. Endocrinology. 2001 Mar; 142(3):1124-9. Tenenhouse HS, Martel J, Gauthier C, Zhang MY, Portale AA. PMID: 11181527.
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    61. Genetics of vitamin D biosynthesis and its disorders. Best Pract Res Clin Endocrinol Metab. 2001 Mar; 15(1):95-109. Miller WL, Portale AA. PMID: 11469813.
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    62. Vitamin D 1 alpha-hydroxylase. Trends Endocrinol Metab. 2000 Oct; 11(8):315-9. Miller WL, Portale AA. PMID: 10996526.
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    63. Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression. Pediatr Nephrol. 2000 Jul; 14(7):620-5. Portale AA, Miller WL. PMID: 10912530.
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    64. Altered diurnal regulation of blood ionized calcium and serum parathyroid hormone concentrations during parenteral nutrition. Am J Clin Nutr. 2000 Feb; 71(2):560-8. Goodman WG, Misra S, Veldhuis JD, Portale AA, Wang HJ, Ament ME, Salusky IB. PMID: 10648272.
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    65. Genetic disorders of vitamin D biosynthesis. Endocrinol Metab Clin North Am. 1999 Dec; 28(4):825-40, x. Miller WL, Portale AA. PMID: 10609122.
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    66. Genetic causes of rickets. Curr Opin Pediatr. 1999 Aug; 11(4):333-9. Miller WL, Portale AA. PMID: 10439207.
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    67. Plasma calcium oxalate supersaturation in children with primary hyperoxaluria and end-stage renal failure. Kidney Int. 1999 Jul; 56(1):268-74. Hoppe B, Kemper MJ, Bökenkamp A, Portale AA, Cohn RA, Langman CB. PMID: 10411702.
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    68. Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families. Am J Hum Genet. 1998 Dec; 63(6):1694-702. Wang JT, Lin CJ, Burridge SM, Fu GK, Labuda M, Portale AA, Miller WL. PMID: 9837822; PMCID: PMC1377641.
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    69. Hereditary rickets revealed. Kidney Int. 1998 Nov; 54(5):1762-4. Portale AA, Miller WL. PMID: 9844157.
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    70. Reduced expression of the renal calcium-sensing receptor in rats with experimental chronic renal insufficiency. J Am Soc Nephrol. 1998 Nov; 9(11):2067-74. Mathias RS, Nguyen HT, Zhang MY, Portale AA. PMID: 9808092.
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    71. Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha. DNA Cell Biol. 1997 Dec; 16(12):1499-507. Fu GK, Portale AA, Miller WL. PMID: 9428799.
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    72. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997 Dec; 11(13):1961-70. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. PMID: 9415400.
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    73. Aging alters calcium regulation of serum concentration of parathyroid hormone in healthy men. Am J Physiol. 1997 Jan; 272(1 Pt 1):E139-46. Portale AA, Lonergan ET, Tanney DM, Halloran BP. PMID: 9038863.
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    74. Aging and renal responsiveness to parathyroid hormone in healthy men. J Clin Endocrinol Metab. 1996 Jun; 81(6):2192-7. Halloran BP, Lonergan ET, Portale AA. PMID: 8964850.
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    75. Effect of aging on the metabolism of phosphorus and 1,25-dihydroxyvitamin D in healthy men. Am J Physiol. 1996 Mar; 270(3 Pt 1):E483-90. Portale AA, Halloran BP, Morris RC, Lonergan ET. PMID: 8638697.
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    76. Resolution of hepatitis B virus-related membranoproliferative glomerulonephritis after orthotopic liver transplantation. Pediatr Nephrol. 1995 Oct; 9(5):599-602. Quan A, Portale A, Foster S, Lavine J. PMID: 8580018.
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    77. Renal transplantation without chronic immunosuppression after T cell-depleted, HLA-mismatched bone marrow transplantation. Transplantation. 1995 Jun 15; 59(11):1633-5. Sorof JM, Koerper MA, Portale AA, Potter D, DeSantes K, Cowan M. PMID: 7778182.
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    78. Acute post-streptococcal glomerulonephritis in a renal allograft. Pediatr Nephrol. 1995 Jun; 9(3):317-9. Sorof JM, Weidner N, Potter D, Portale AA. PMID: 7632522.
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    79. Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men. Am J Physiol. 1992 12; 263(6):E1164-70. Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC. PMID: 1476189.
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    80. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1992 Aug; 75(2):519-23. Bikle DD, Halloran BP, Harris ST, Portale AA. PMID: 1639954.
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    81. Foscarnet-induced hypocalcemia and effects of foscarnet on calcium metabolism. J Clin Endocrinol Metab. 1991 May; 72(5):1130-5. Jacobson MA, Gambertoglio JG, Aweeka FT, Causey DM, Portale AA. PMID: 1827127.
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    82. Are blood transfusions beneficial in the cyclosporine era? Pediatr Nephrol. 1991 Jan; 5(1):168-72. Potter DE, Portale AA, Melzer JS, Feduska NJ, Garovoy MR, Husing RM, Salvatierra O. PMID: 2025530.
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    83. Pathogenesis of secondary hyperparathyroidism in chronic renal insufficiency. Miner Electrolyte Metab. 1991; 17(4):211-20. Portale AA, Morris RC. PMID: 1813783.
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    84. Dietary potassium influences kidney maintenance of serum phosphorus concentration. Kidney Int. 1990 May; 37(5):1341-9. Sebastian A, Hernandez RE, Portale AA, Colman J, Tatsuno J, Morris RC. PMID: 2345430.
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    85. Production and metabolic clearance of 1,25-dihydroxyvitamin D in men: effect of advancing age. J Clin Endocrinol Metab. 1990 Feb; 70(2):318-23. Halloran BP, Portale AA, Lonergan ET, Morris RC. PMID: 2298850.
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    86. Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest. 1989 May; 83(5):1494-9. Portale AA, Halloran BP, Morris RC. PMID: 2708521; PMCID: PMC303852.
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    87. Pregnancy complicated by maternal spina bifida. A report of two cases. J Reprod Med. 1988 Mar; 33(3):323-6. Farine D, Jackson U, Portale A, Baxi L, Fox HE. PMID: 3283355.
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    88. Dietary intake of phosphorus modulates the circadian rhythm in serum concentration of phosphorus. Implications for the renal production of 1,25-dihydroxyvitamin D. J Clin Invest. 1987 Oct; 80(4):1147-54. Portale AA, Halloran BP, Morris RC. PMID: 3654974; PMCID: PMC442358.
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    89. Evidence for a difference in vitamin D metabolism between spontaneously hypertensive and Wistar-Kyoto rats. Hypertension. 1986 Nov; 8(11):1015-20. Kurtz TW, Portale AA, Morris RC. PMID: 3770864.
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    90. Comparison of continuous ambulatory peritoneal dialysis and hemodialysis in children. Kidney Int Suppl. 1986 Jul; 19:S11-4. Potter DE, San Luis E, Wipfler JE, Portale AA. PMID: 3462423.
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    91. Liquid-chromatographic measurements of inosine, hypoxanthine, and xanthine in studies of fructose-induced degradation of adenine nucleotides in humans and rats. Clin Chem. 1986 May; 32(5):782-6. Kurtz TW, Kabra PM, Booth BE, Al-Bander HA, Portale AA, Serena BG, Tsai HC, Morris RC. PMID: 3698269.
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    92. Renal osteodystrophy in children: the role of vitamin D, phosphorus, and parathyroid hormone. Am J Kidney Dis. 1986 Apr; 7(4):275-84. Chesney RW, Mehls O, Anast CS, Brown E, Hammerman MR, Portale A, Fallon MD, Mahan J, Alfrey AC. PMID: 3515907.
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    93. Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans. J Clin Invest. 1986 Jan; 77(1):7-12. Portale AA, Halloran BP, Murphy MM, Morris RC. PMID: 3753709; PMCID: PMC423300.
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    94. Serum concentration of 1,25-dihydroxyvitamin D in the human: diurnal variation. J Clin Endocrinol Metab. 1985 Jun; 60(6):1104-10. Halloran BP, Portale AA, Castro M, Morris RC, Goldsmith RS. PMID: 3998063.
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    95. Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J Clin Invest. 1984 Jun; 73(6):1580-9. Portale AA, Booth BE, Halloran BP, Morris RC. PMID: 6547151; PMCID: PMC437069.
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    96. Hemoperfusion in a child who ingested diquat and died from pontine infarction and hemorrhage. J Toxicol Clin Toxicol. 1983 Jul; 20(5):405-20. Powell D, Pond SM, Allen TB, Portale AA. PMID: 6668627.
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    97. Reduced plasma concentration of 1,25-dihydroxyvitamin D in children with moderate renal insufficiency. Kidney Int. 1982 Apr; 21(4):627-32. Portale AA, Booth BE, Tsai HC, Morris RC. PMID: 6896541.
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    98. [Clinical study of the effects of metisoprinol in the treatment of mumps in adults]. Clin Ter. 1980 Dec 31; 95(6):681-5. Galvagna S, Rosella PP, Portale A. PMID: 6163586.
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    99. Nutritional management of chronic renal disease. Med Clin North Am. 1979 Sep; 63(5):945-62. Holliday MA, McHenry-Richardson K, Portale A. PMID: 388114.
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