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High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris. J Proteome Res. 2012 Dec 07; 11(12):5720-35.
Walian PJ, Allen S, Shatsky M, Zeng L, Szakal ED, Liu H, Hall SC, Fisher SJ, Lam BR, Singer ME, Geller JT, Brenner SE, Chandonia JM, Hazen TC, Witkowska HE, Biggin MD, Jap BK. PMID: 23098413; PMCID: PMC3516867.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers. J Proteome Res. 2012 Apr 06; 11(4):2508-20.
Drake PM, Schilling B, Niles RK, Prakobphol A, Li B, Jung K, Cho W, Braten M, Inerowicz HD, Williams K, Albertolle M, Held JM, Iacovides D, Sorensen DJ, Griffith OL, Johansen E, Zawadzka AM, Cusack MP, Allen S, Gormley M, Hall SC, Witkowska HE, Gray JW, Regnier F, Gibson BW, Fisher SJ. PMID: 22309216; PMCID: PMC3383053.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Cells Tissues Organs. Amelogenin Exons 8 and 9 Encoded Peptide Enhances Leucine Rich Amelogenin Peptide Mediated Dental Pulp Repair. 2012; 198(2):151-60.
Huang Y, Goldberg M, Le T, Qiang R, Warner D, Witkowska HE, Liu H, Zhu L, Denbesten P, and Li W.
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Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe. 2011 Dec 15; 10(6):541-50.
Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC. PMID: 22177559; PMCID: PMC3257029.
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PubMed Mentions:
93 Fields:
Translation:
HumansCells
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Breaking the bottleneck in the protein biomarker pipeline. Clin Chem. 2012 Feb; 58(2):321-3.
Witkowska HE, Hall SC, Fisher SJ. PMID: 22140214.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Evidence-based annotation of transcripts and proteins in the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough. J Bacteriol. 2011 Oct; 193(20):5716-27.
Price MN, Deutschbauer AM, Kuehl JV, Liu H, Witkowska HE, Arkin AP. PMID: 21840973; PMCID: PMC3187205.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Automated iterative MS/MS acquisition: a tool for improving efficiency of protein identification using a LC-MALDI MS workflow. Anal Chem. 2011 Aug 15; 83(16):6286-93.
Liu H, Yang L, Khainovski N, Dong M, Hall SC, Fisher SJ, Biggin MD, Jin J, Witkowska HE. PMID: 21761829.
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PubMed Mentions:
6 Fields:
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ABRF-PRG07: advanced quantitative proteomics study. J Biomol Tech. 2011 Apr; 22(1):21-6.
Falick AM, Lane WS, Lilley KS, MacCoss MJ, Phinney BS, Sherman NE, Weintraub ST, Witkowska HE, Yates NA. PMID: 21455478; PMCID: PMC3059538.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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The ABRF Proteomics Research Group studies: educational exercises for qualitative and quantitative proteomic analyses. Proteomics. 2011 Apr; 11(8):1371-81.
Friedman DB, Andacht TM, Bunger MK, Chien AS, Hawke DH, Krijgsveld J, Lane WS, Lilley KS, MacCoss MJ, Moritz RL, Settlage RE, Sherman NE, Weintraub ST, Witkowska HE, Yates NA, Turck CW. PMID: 21394914.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Eur J Oral Sci. Fluoride incorporation into apatite crystals delays amelogenin hydrolysis. 2011; 2011(Suppl 1):3-7.
Denbesten PK, Zhu L, Li W, Tanimoto K, Liu H, and Witkowska HE.
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Arch Oral Biol. Hydrolysis of amelogenin by matrix metalloprotease-20 accelerates mineralization in vitro. 2011; 56(12):1548-1559.
Uskokovic V, Khan F, Liu H, Witkowska HE, Zhu L, Li W, and Habelitz S.
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A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma. Anal Biochem. 2011 Jan 01; 408(1):71-85.
Drake PM, Schilling B, Niles RK, Braten M, Johansen E, Liu H, Lerch M, Sorensen DJ, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ. PMID: 20705048; PMCID: PMC3205961.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Survey of large protein complexes in D. vulgaris reveals great structural diversity. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16580-5.
Han BG, Dong M, Liu H, Camp L, Geller J, Singer M, Hazen TC, Choi M, Witkowska HE, Ball DA, Typke D, Downing KH, Shatsky M, Brenner SE, Chandonia JM, Biggin MD, Glaeser RM. PMID: 19805340; PMCID: PMC2742403.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors. J Biol Chem. 2009 Sep 25; 284(39):26666-75.
Meima ME, Webb BA, Witkowska HE, Barber DL. PMID: 19622752; PMCID: PMC2785354.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Acid-catalyzed oxygen-18 labeling of peptides. Anal Chem. 2009 Apr 01; 81(7):2804-9.
Niles R, Witkowska HE, Allen S, Hall SC, Fisher SJ, Hardt M. PMID: 19243188; PMCID: PMC2892872.
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PubMed Mentions:
18 Fields:
Translation:
Cells
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Rapid alterations in cortical protein profiles underlie spontaneous sleep and wake bouts. J Cell Biochem. 2008 Dec 15; 105(6):1472-84.
Vazquez J, Hall SC, Witkowska HE, Greco MA. PMID: 19003977.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res. 2008 May; 7(5):1994-2006.
Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ. PMID: 18361515; PMCID: PMC2839126.
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PubMed Mentions:
150 Fields:
Translation:
Humans
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A "tagless" strategy for identification of stable protein complexes genome-wide by multidimensional orthogonal chromatographic separation and iTRAQ reagent tracking. J Proteome Res. 2008 May; 7(5):1836-49.
Dong M, Yang LL, Williams K, Fisher SJ, Hall SC, Biggin MD, Jin J, Witkowska HE. PMID: 18336004.
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PubMed Mentions:
22 Fields:
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A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples. Proteomics. 2008 Feb; 8(3):435-45.
Robinson S, Niles RK, Witkowska HE, Rittenbach KJ, Nichols RJ, Sargent JA, Dixon SE, Prakobphol A, Hall SC, Fisher SJ, Hardt M. PMID: 18186022.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Natural Product Communications. Analysis of saponin mixtures from Alfaalfa (Medicago sativa L.) roots using mass spectrometry with Maldi techniques. 2008; 3(9):1395-1410.
Witkowska HE, Bialy Z, Jurzysta M, and Waller GR.
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J Dent Res. Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta. 2008; 87(5):451-55.
Tanimoto K, Le T, Zhu L, Witkowska HE, Robinson S, Hall S, Hwang P, Denbesten P, and Li Wu.
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Octomeric pyruvate-ferredoxin oxidoreductase from Desulfovibrio vulgaris. J Struct Biol. 2007 Jul; 159(1):9-18.
Garczarek F, Dong M, Typke D, Witkowska HE, Hazen TC, Nogales E, Biggin MD, Glaeser RM. PMID: 17400475.
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PubMed Mentions:
11 Fields:
Translation:
Cells
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Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution. J Lipid Res. 2007 May; 48(5):1035-44.
Peters-Libeu CA, Newhouse Y, Hall SC, Witkowska HE, Weisgraber KH. PMID: 17308333.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15588-93.
Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC. PMID: 17030807; PMCID: PMC1592537.
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PubMed Mentions:
146 Fields:
Translation:
HumansCells
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Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents. Anal Chem. 2005 Aug 01; 77(15):4947-54.
Hardt M, Witkowska HE, Webb S, Thomas LR, Dixon SE, Hall SC, Fisher SJ. PMID: 16053308.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS-PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry. 2005 Mar 01; 44(8):2885-99.
Hardt M, Thomas LR, Dixon SE, Newport G, Agabian N, Prakobphol A, Hall SC, Witkowska HE, Fisher SJ. PMID: 15723531.
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PubMed Mentions:
36 Fields:
Translation:
HumansCells
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Head-to-head coiled arrangement of the subunits of the animal fatty acid synthase. Chem Biol. 2004 Dec; 11(12):1667-76.
Witkowski A, Ghosal A, Joshi AK, Witkowska HE, Asturias FJ, Smith S. PMID: 15610851.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Characterization of embryonic globin genes of the zebrafish. Dev Biol. 2003 Mar 01; 255(1):48-61.
Brownlie A, Hersey C, Oates AC, Paw BH, Falick AM, Witkowska HE, Flint J, Higgs D, Jessen J, Bahary N, Zhu H, Lin S, Zon L. PMID: 12618133.
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PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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J Chromatogr B Biomed Sci Appl. Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation. 2001; 759(1):1-15.
Zhang X, Medzihradszky KF, Cunningham J, Lee PD, Rognerud CL, Ou CN, Harmatz P, and Witkowska HE.
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Blood. Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. 2000; 95(5):1827-33.
Perkins AC, Peterson KR, Stamatoyannopoulos G, Witkowska HE, and Orkin SH.
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J Biol Chem. Dibromopropanone cross-linking of the phosphopantetheine and active-site cysteine thiols of the animal fatty acid synthase can occur both inter- and intrasubunit. Reevaluation of the side-by-side, antiparallel subunit model. 1999; 247(17):11557-63.
Witkowski A, Joshi AK, Rangan VS, Falick AM, Witkowska HE, and Smith S.
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Nat Genet. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. 1998; 20(3):244-50.
Brownlie A, Donovan A, Pratt SJ, Paw BH, Oates AC, Brugnara C, Witkowska HE, Sassa S, and Zon LI.
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Blood. Characterization of adult alpha- and beta-globin genes in the zebrafish. 1997; 89(2):688-700.
Chan FY, Robinson J, Brownlie A, Shivdasani RA, Donovan A, Brugnara C, Kim J, Lau BC, Witkowska HE, and Zon LI.
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Science. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. 1997; 278(5339):876-8.
Paszty C, Brion CM, Manci E, Witkowska HE, Stevens ME, Mohandas N, and Rubin EM.
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Blood. The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice. 1997; 90(11):4602-9.
Porcu S, Kitamura M, Witkowska E, Zhang Z, Mutero A, Lin C, Chang J, and Gaensler KM.
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Steroids. Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: structural comparison with estrogen receptor alpha. 1997; 62(8-9):621-31.
Witkowska HE, Carlquist M, Engstrom O, Carlsson B, Bonn T, Gustafsson JA, and Shackleton CH.
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Br J Haematol. HbC compound heterozygotes [HbC/Hb Riyadh and HbC/Hb N-Baltimore] with opposing effects upon HbC crystallization. 1997; 97(2):259-65.
Hirsch RE, Witkowska HE, Shafer F, Lin MJ, Balazs TC, Bookchin RM, and Nagel RL.
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Anal Chem. Characterizing abnormal hemoglobin by MS. 1996; 68(1):29A-33A.
Shackleton CH, and Witkowska HE.
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J Biol Chem. Expression of soluble human beta-globin chains in bacteria and assembly in vitro with alpha-globin chains. 1996; 271(43):26677-83.
Yamaguchi T, Pang J, Reddy KS, Witkowska HE, Surrey S, and Adachi K.
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J Am Chem Soc,. Mass spectrometric analysis of a native zinc finger structure: the glucocorticoid receptor DNA binding domain. 1995; 117:3319-24.
Witkowska HE, Shackleton CHL, Dahlman-Wright K, Kim JY, Gustaffson JA. (1995) .
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Rapid Commun Mass Spectrom. Intact protein electrospray ionization tandem mass spectrometry can be the sole technique used for confirming the structure of a variant hemoglobin. 1995; (Spec):S111-S115.
Witkowska HE, Green BN, Morris M, and Shackleton CH.
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Biochemistry. Incorporation of norleucine at methionine positions in recombinant human macrophage colony stimulating factor (M-CSF, 4-153) expressed in Escherichia coli: structural analysis. 1994; 34(14):4352-62.
Randhawa ZI, Witkowska HE, Cone J, Wilkins JA, Hughes P, Yamanishi K, Yasuda S, Masui Y, Arthur P, Kletke C, and et al.
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Hemoglobin. Expediting rare variant hemoglobin characterization by combined HPLC/electrospray mass spectrometry. 1993; 17(3):227-42.
Witkowska HE, Bitsch F, and Shackleton CH.
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Biol Mass Spectrom. Collisionally activated dissociation and tandem mass spectrometry of intact hemoglobin beta-chain variant proteins with electrospray ionization. 1993; 22(2):112-20.
Light-Wahl KJ, Loo JA, Edmonds CG, Smith RD, Witkowska HE, Shackleton CH, and Wu CS.
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N Engl J Med. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. 1993; 328(2):81-6.
Perrine SP, Ginder GD, Faller DV, Dover GH, Ikuta T, Witkowska HE, Cai SP, Vichinsky EP, and Olivieri NF.
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Protein Sci. A study of intermediates involved in the folding pathway for recombinant human macrophage colony-stimulating factor (M-CSF): evidence for two distinct folding pathways. 1993; 2(2):244-54.
Wilkins JA, Cone J, Randhawa ZI, Wood D, Warren MK, and Witkowska HE.
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J Clin Invest. Hypoxia-induced in vivo sickling of transgenic mouse red cells. 1991; 87(2):639-47.
Rubin EM, Witkowska HE, Spangler E, Curtin P, Lubin BH, Mohandas N, and Clift SM.
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N Engl J Med. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. 1991; 325(16):1150-4.
Witkowska HE, Lubin BH, Beuzard Y, Baruchel S, Esseltine DW, Vichinsky EP, Kleman KM, Bardakdjian-Michau J, Pinkoski L, Cahn S, and et al.
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J Biol Chem. The carboxyl-terminal region of thioesterase II participates in the interaction with fatty acid synthase. Use of electrospray ionization mass spectrometry to identify a carboxyl-terminally truncated form of the enzyme. 1990; 265(10):5662-5.
Witkowska HE, Green BN, and Smith S.