Emin Maltepe, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #1422
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of Chicago, Chicago, ILPhD1998Pathology
    University of ChicagoM.D.2001Pritzker School of Medicine
    University of California, San FranciscoResidency 2004
    University of California, San FranciscoFellowship2007Neonatal-Perinatal Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass
    NIH/NICHD R44 HD094414-05Sep 1, 2023 - Aug 31, 2026
    Role: Co-PI
    An Anticoagulation-Free Artificial Placenta Device
    NIH R21HD113527Aug 1, 2023 - Jul 31, 2025
    Role: Co-Investigator
    OMX-CV, A Novel Oxygen Delivery Biotherapeutic for Treatment of Hemorrhagic Shock in the Battlefield
    DOD DM190076Aug 3, 2020 - Jul 31, 2024
    Role: Principal Investigator
    Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease
    NIH/NHLBI P01HL146369Aug 1, 2020 - Jul 31, 2025
    Role: Co-I
    Large Mammal Neuroprotective Clinical Platform
    Bill and Melinda Gates Foundation OPP1196539Aug 1, 2018 - Jul 31, 2024
    Role: Principal Investigator
    Precision Therapy for Neonatal Brain Injury
    NIH R35NS097299Dec 1, 2016 - Nov 30, 2024
    Role: Co-Investigator
    Integrating Environmental Cues at the Maternal-Fetal Vascular Interface
    NIH R01HD072455Aug 1, 2012 - Apr 30, 2024
    Role: Principal Investigator
    Altered Lymphatic Function and Development in Congenital Heart Disease
    NIH/NHLBI R01HL133034Jun 1, 2006 - May 31, 2027
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. OMX: A Novel Oxygen Delivery Biotherapeutic Improves Outcomes in an Ovine Model of Controlled Hemorrhagic Shock. Shock. 2024 Apr 23. Maltepe E, Smith M, Boehme J, Datar SA, Hutchings RS, Vento CA, Manzoor H, Loucks A, Winger JA, Fineman JR. PMID: 38662597.
      View in: PubMed   Mentions:
    2. The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States. J Perinatol. 2024 Feb; 44(2):187-194. Sharma M, Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA. PMID: 38212435; PMCID: PMC10844066.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. 3 Development, Function, and Pathology of the Placenta. Avery's Diseases of the Newborn. 2024 Jan 1; (Am J Obstet Gynecol 204 2011):19-32.e7. MALTEPE ME, PENN PA. .
      View in: Publisher Site   Mentions:
    4. Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy. Children (Basel). 2023 Oct 25; 10(11). Mike JK, White Y, Hutchings RS, Vento C, Ha J, Iranmahboub A, Manzoor H, Gunewardena A, Cheah C, Wang A, Goudy BD, Lakshminrusimha S, Long-Boyle J, Fineman JR, Ferriero DM, Maltepe E. PMID: 38002819; PMCID: PMC10670092.
      View in: PubMed   Mentions:
    5. Perinatal Azithromycin Provides Limited Neuroprotection in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy. Stroke. 2023 11; 54(11):2864-2874. Mike JK, White Y, Hutchings RS, Vento C, Ha J, Manzoor H, Lee D, Losser C, Arellano K, Vanhatalo O, Seifert E, Gunewardena A, Wen B, Wang L, Wang A, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Wu YW, Fineman JR, Ferriero DM, Maltepe E. PMID: 37846563; PMCID: PMC10589434.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial. Sci Rep. 2023 06 10; 13(1):9467. Sabir H, Maes E, Zweyer M, Schleehuber Y, Imam FB, Silverman J, White Y, Pang R, Pasca AM, Robertson NJ, Maltepe E, Bernis ME. PMID: 37301929; PMCID: PMC10257179.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    7. Fertility treatment increases the risk of preterm birth independent of multiple gestations. F S Rep. 2023 Sep; 4(3):313-320. Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA. PMID: 37719103; PMCID: PMC10504569.
      View in: PubMed   Mentions:
    8. Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases. Circulation. 2022 Nov 8; 146(Suppl_1):a13625-a13625. Liang LY, Ornatowski OW, Lu LQ, Sun SX, Garcia GA, Zemskov ZE, Maltepe ME, Fineman FJ, Tieu TK, Wang WT, Black BS. .
      View in: Publisher Site   Mentions:
    9. Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease. Am J Obstet Gynecol. 2023 02; 228(2):187-202. Redline RW, Roberts DJ, Parast MM, Ernst LM, Morgan TK, Greene MF, Gyamfi-Bannerman C, Louis JM, Maltepe E, Mestan KK, Romero R, Stone J. PMID: 35973475; PMCID: PMC10337668.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    10. Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia. Dev Neurosci. 2022; 44(4-5):277-294. Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E. PMID: 35588703; PMCID: PMC9474697.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases. Free Radical Biology and Medicine. 2022 Feb 1; 180:s52. Ornatowski OW, Lu LQ, Sun SX, Flores FA, Feng FA, Zemskov ZE, Maltepe ME, Fineman FJ, Wang WT, Black BS. .
      View in: Publisher Site   Mentions:
    12. Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species. . 2021 Sep 9; 96-100. Boehme BJ, Maltepe ME. .
      View in: Publisher Site   Mentions:
    13. Outcomes of Very Preterm Infants Conceived with Assisted Reproductive Technologies. J Pediatr. 2021 Sep; 236:47-53.e1. Fineman DC, Keller RL, Maltepe E, Rinaudo PF, Steurer MA. PMID: 34023343.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Monitoring deep-tissue oxygenation with a millimeter-scale ultrasonic implant. Nat Biotechnol. 2021 07; 39(7):855-864. Sonmezoglu S, Fineman JR, Maltepe E, Maharbiz MM. PMID: 33782610.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    15. HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Sci Rep. 2021 01 14; 11(1):1468. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. PMID: 33446832; PMCID: PMC7809484.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF. Mol Hum Reprod. 2020 11 01; 26(11):866-878. Ruggeri E, Lira-Albarrán S, Grow EJ, Liu X, Harner R, Maltepe E, Ramalho-Santos M, Donjacour A, Rinaudo P. PMID: 33010164; PMCID: PMC7821709.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Effect of culture conditions and method of conception on mouse live birth rate. F S Sci. 2020 Nov; 1(2):132-141. Xiao Z, Donjacour A, Harner R, Simbulan R, Kao CN, Ruggeri E, Liu X, Maltepe E, Rinaudo P. PMID: 35559924.
      View in: PubMed   Mentions: 1     Fields:    
    18. Defining the ATPome reveals cross-optimization of metabolic pathways. Nat Commun. 2020 08 28; 11(1):4319. Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. PMID: 32859923; PMCID: PMC7455733.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    19. Human placental trophoblast progenitor cells (hTPCs) promote angiogenesis and neurogenesis after focal cerebral ischemia in rats. Int J Neurosci. 2022 Mar; 132(3):258-268. Molbay M, Özaydin-Goksu E, Kipmen-Korgun D, Unal A, Ozekinci M, Cebeci E, Maltepe E, Korgun ET. PMID: 32772609.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Complex interplay between autophagy and oxidative stress in the development of pulmonary disease. Redox Biol. 2020 09; 36:101679. Ornatowski W, Lu Q, Yegambaram M, Garcia AE, Zemskov EA, Maltepe E, Fineman JR, Wang T, Black SM. PMID: 32818797; PMCID: PMC7451718.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    21. Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020922118. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. PMID: 32489641; PMCID: PMC7238833.
      View in: PubMed   Mentions: 1  
    22. Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease. Biophysical Journal. 2020 Feb 1; 118(3):251a-252a. Garcia-Herreros GA, Kameny KR, Zhu ZT, Boehme BJ, Raff RG, Lasheras LJ, Black BS, Maltepe ME, Datar DS, Fineman FJ. .
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    23. Outcomes of pulmonary vascular disease in infants conceived with non-IVF fertility treatment and assisted reproductive technologies at 1 year of age. Pediatr Pulmonol. 2019 11; 54(11):1844-1852. Fineman DC, Baer RJ, Chambers CD, Rajagopal S, Maltepe E, Rinaudo PF, Fineman JR, Jelliffe-Pawlowski LL, Steurer MA. PMID: 31328432.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling. Am J Respir Cell Mol Biol. 2019 05; 60(5):503-514. Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR. PMID: 30620615; PMCID: PMC6503613.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    25. Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury. Front Physiol. 2019; 10:511. Kelly GT, Faraj R, Zhang Y, Maltepe E, Fineman JR, Black SM, Wang T. PMID: 31105595; PMCID: PMC6498899.
      View in: PubMed   Mentions: 9  
    26. The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification. PLoS One. 2019; 14(4):e0214110. Abed M, Verschueren E, Budayeva H, Liu P, Kirkpatrick DS, Reja R, Kummerfeld SK, Webster JD, Gierke S, Reichelt M, Anderson KR, Newman RJ, Roose-Girma M, Modrusan Z, Pektas H, Maltepe E, Newton K, Dixit VM. PMID: 30951545; PMCID: PMC6450627.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    27. Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease. Antioxid Redox Signal. 2019 10 20; 31(12):819-842. Zemskov EA, Lu Q, Ornatowski W, Klinger CN, Desai AA, Maltepe E, Yuan JX, Wang T, Fineman JR, Black SM. PMID: 30623676; PMCID: PMC6751394.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. Murine trophoblast-derived and pregnancy-associated exosome-enriched extracellular vesicle microRNAs: Implications for placenta driven effects on maternal physiology. PLoS One. 2019; 14(2):e0210675. Stefanski AL, Martinez N, Peterson LK, Callahan TJ, Treacy E, Luck M, Friend SF, Hermesch A, Maltepe E, Phang T, Dragone LL, Winn VD. PMID: 30730971; PMCID: PMC6366741.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2019 Jan; 17(1):e3000119. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30677022; PMCID: PMC6345423.
      View in: PubMed   Mentions: 1     Fields:    
    30. Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2018 10; 16(10):e2005924. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30335746; PMCID: PMC6193608.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    31. KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H173-H181. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. PMID: 29631374; PMCID: PMC6087778.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury. Cerebellum. 2018 Apr; 17(2):213-227. Nguyen V, Sabeur K, Maltepe E, Ameri K, Bayraktar O, Rowitch DH. PMID: 29134361; PMCID: PMC5849674.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. 5 Development, Function, and Pathology of the Placenta. . 2018 Jan 1; (Am J Obstet Gynecol 204 2011):40-60.e8. Maltepe ME, Penn PA. .
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    34. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatr Crit Care Med. 2017 Oct; 18(10):931-934. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR. PMID: 28723882; PMCID: PMC5628126.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. Common and specific transcriptional signatures in mouse embryos and adult tissues induced by in vitro procedures. Reproduction. 2016 Oct 31. Feuer S, Liu X, Donjacour A, Simbulan R, Maltepe E, Rinaudo P. PMID: 27799627; PMCID: PMC5411347.
      View in: PubMed   Mentions: 9     Fields:    
    36. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 10 01; 311(4):H944-H957. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. PMID: 27591215; PMCID: PMC5114466.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    37. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2016 07 01; 311(1):H137-45. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. PMID: 27199125; PMCID: PMC4967199.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One. 2016; 11(3):e0150480. Rafikova O, Meadows ML, Kinchen JM, Mohney RP, Maltepe E, Desai AA, Yuan JX, Garcia JG, Fineman JR, Rafikov R, Black SM. PMID: 26937637; PMCID: PMC4777490.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    39. Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue. J Dev Orig Health Dis. 2016 Feb; 7(1):73-82. Simbulan RK, Liu X, Feuer SK, Maltepe E, Donjacour A, Rinaudo P. PMID: 26511158.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    40. Placenta: the forgotten organ. Annu Rev Cell Dev Biol. 2015; 31:523-52. Maltepe E, Fisher SJ. PMID: 26443191.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    41. Abstract 640: PASMC Hyperproliferation and Metabolic Shift in a Model of Pulmonary Overcirculation. Arteriosclerosis Thrombosis and Vascular Biology. 2015 May 1; 35(suppl_1). Boehme BJ, Tormos TK, Fineman FJ, Maltepe ME. .
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    42. HIGD1A-mediated dormancy and tumor survival. Mol Cell Oncol. 2015 Oct-Dec; 2(4):e1030537. Ameri K, Maltepe E. PMID: 27308509; PMCID: PMC4905353.
      View in: PubMed   Mentions: 10  
    43. Embryonic stem cells derived from in vivo or in vitro-generated murine blastocysts display similar transcriptome and differentiation potential. PLoS One. 2015; 10(2):e0117422. Simbulan RK, Di Santo M, Liu X, Lin W, Donjacour A, Maltepe E, Shenoy A, Borini A, Rinaudo P. PMID: 25723476; PMCID: PMC4344309.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. Spare hypoxia, spoil the child? J Clin Invest. 2015 Mar 02; 125(3):965-7. Boehme J, Maltepe E. PMID: 25689257; PMCID: PMC4362258.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    45. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 17; 10(6):891-899. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. PMID: 25683712; PMCID: PMC4534363.
      View in: PubMed   Mentions: 46     Fields:    
    46. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am J Pathol. 2014 Dec; 184(12):3321-31. Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E. PMID: 25307528; PMCID: PMC4258498.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    47. Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes. Endocrinology. 2014 Nov; 155(11):4554-67. Feuer SK, Donjacour A, Simbulan RK, Lin W, Liu X, Maltepe E, Rinaudo PF. PMID: 25211591; PMCID: PMC4197990.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    48. Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell. 2014 Jul 17; 158(2):383-396. Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH. PMID: 25018103; PMCID: PMC4149873.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    49. Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6). The FASEB Journal. 2014 Apr 1; 28. Bahney BC, Taylor TA, Sadat SA, Tormos TK, Miclau MT, Maltepe ME, Marcucio MR. .
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    50. Use of a mouse in vitro fertilization model to understand the developmental origins of health and disease hypothesis. Endocrinology. 2014 May; 155(5):1956-69. Feuer SK, Liu X, Donjacour A, Lin W, Simbulan RK, Giritharan G, Piane LD, Kolahi K, Ameri K, Maltepe E, Rinaudo PF. PMID: 24684304; PMCID: PMC3990843.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    51. Placental syncytium forms a biophysical barrier against pathogen invasion. PLoS Pathog. 2013; 9(12):e1003821. Zeldovich VB, Clausen CH, Bradford E, Fletcher DA, Maltepe E, Robbins JR, Bakardjiev AI. PMID: 24348256; PMCID: PMC3861541.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    52. Hypoxia and trophoblast differentiation: a key role for PPARγ. Stem Cells Dev. 2013 Nov 01; 22(21):2815-24. Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM. PMID: 23767827; PMCID: PMC3804243.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    53. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One. 2013; 8(4):e62758. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E. PMID: 23646141; PMCID: PMC3639984.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    54. The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos. Dis Model Mech. 2013 Jul; 6(4):915-24. Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS. PMID: 23592613; PMCID: PMC3701211.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    55. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS One. 2013; 8(2):e56949. Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E. PMID: 23437279; PMCID: PMC3578927.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    56. Effect of ICSI on gene expression and development of mouse preimplantation embryos. Human Reproduction. 2013 Jan 1; 28(1):285-285. Giritharan GG, Li LM, Di Sebastiano DF, Esteban EF, Horcajadas HJ, Lloyd LK, Donjacour DA, Maltepe ME, Rinaudo RP. .
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    57. Effect of substrate stiffness on early mouse embryo development. PLoS One. 2012; 7(7):e41717. Kolahi KS, Donjacour A, Liu X, Lin W, Simbulan RK, Bloise E, Maltepe E, Rinaudo P. PMID: 22860009; PMCID: PMC3409240.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    58. Impaired placental nutrient transport in mice generated by in vitro fertilization. Endocrinology. 2012 Jul; 153(7):3457-67. Bloise E, Lin W, Liu X, Simbulan R, Kolahi KS, Petraglia F, Maltepe E, Donjacour A, Rinaudo P. PMID: 22562173; PMCID: PMC3380310.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    59. In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm. Reprod Sci. 2012 Mar; 19(3):243-52. Giritharan G, Delle Piane L, Donjacour A, Esteban FJ, Horcajadas JA, Maltepe E, Rinaudo P. PMID: 22383776; PMCID: PMC3343151.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    60. A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia. Development. 2011 Jul; 138(14):2987-98. Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross JC, Fisher SJ. PMID: 21693515; PMCID: PMC3119307.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    61. Effect of ICSI on gene expression and development of mouse preimplantation embryos. Hum Reprod. 2010 Dec; 25(12):3012-24. Giritharan G, Li MW, Di Sebastiano F, De Sebastiano F, Esteban FJ, Horcajadas JA, Lloyd KC, Donjacour A, Maltepe E, Rinaudo PF. PMID: 20889529; PMCID: PMC2989873.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    62. Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care. Semin Fetal Neonatal Med. 2010 Aug; 15(4):196-202. Park AM, Sanders TA, Maltepe E. PMID: 20599462; PMCID: PMC2924157.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    63. Effect of the method of conception and embryo transfer procedure on mid-gestation placenta and fetal development in an IVF mouse model. Hum Reprod. 2010 Aug; 25(8):2039-46. Delle Piane L, Lin W, Liu X, Donjacour A, Minasi P, Revelli A, Maltepe E, Rinaudo PF. PMID: 20576634; PMCID: PMC2907231.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    64. The placenta: transcriptional, epigenetic, and physiological integration during development. J Clin Invest. 2010 Apr; 120(4):1016-25. Maltepe E, Bakardjiev AI, Fisher SJ. PMID: 20364099; PMCID: PMC2846055.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    65. Oxygen in health and disease: regulation of oxygen homeostasis--clinical implications. Pediatr Res. 2009 Mar; 65(3):261-8. Maltepe E, Saugstad OD. PMID: 18852690.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    66. Role of oxygen in early development and embryonic stem cell derivation. Stem Cells in Human Reproduction. 2006 Dec 5; 201-210. Genbacev GO, Rinaudo RP, Maltepe ME. .
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    67. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Journal of Clinical Investigation. 2006 Oct 2; 116(10):2643-2652. Red-Horse RK, Rivera RJ, Schanz SA, Zhou ZY, Winn WV, Kapidzic KM, Maltepe ME, Okazaki OK, Kochman KR, Vo VK, Giudice GL, Erlebacher EA, McCune MJ, Stoddart SC, Fisher FS. .
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    68. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest. 2006 Oct; 116(10):2643-52. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. PMID: 16998586; PMCID: PMC1570373.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    69. Oxygen, epigenetics and stem cell fate. Regen Med. 2006 Jan; 1(1):71-83. Okazaki K, Maltepe E. PMID: 17465821.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    70. Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. Lymphat Res Biol. 2006; 4(4):229-42. Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. PMID: 17394406.
      View in: PubMed   Mentions:    Fields:    
    71. Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol. 2005 Dec; 25(23):10479-91. Cowden Dahl KD, Fryer BH, Mack FA, Compernolle V, Maltepe E, Adelman DM, Carmeliet P, Simon MC. PMID: 16287860; PMCID: PMC1291235.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    72. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005 Aug; 132(15):3393-403. Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ. PMID: 15987772.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    73. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev. 2000 Dec 15; 14(24):3191-203. Adelman DM, Gertsenstein M, Nagy A, Simon MC, Maltepe E. PMID: 11124810; PMCID: PMC317149.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    74. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes & Development. 2000 Dec 15; 14(24):3191-3203. Adelman AD, Gertsenstein GM, Nagy NA, Simon SM, Maltepe ME. .
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    75. TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. Am J Pathol. 2000 Aug; 157(2):679-88. Shiels H, Li X, Schumacker PT, Maltepe E, Padrid PA, Sperling A, Thompson CB, Lindsten T. PMID: 10934170; PMCID: PMC1850138.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    76. The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia. Biochem Biophys Res Commun. 2000 Jun 24; 273(1):231-8. Maltepe E, Keith B, Arsham AM, Brorson JR, Simon MC. PMID: 10873592.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    77. HIF-1 is essential for multilineage hematopoiesis in the embryo. Adv Exp Med Biol. 2000; 475:275-84. Adelman DM, Maltepe E, Simon MC. PMID: 10849668.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    78. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev. 1999 Oct 01; 13(19):2478-83. Adelman DM, Maltepe E, Simon MC. PMID: 10521392; PMCID: PMC317070.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    79. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11715-20. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. PMID: 9751731; PMCID: PMC21706.
      View in: PubMed   Mentions: 653     Fields:    Translation:HumansCells
    80. Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development. J Mol Med (Berl). 1998 May; 76(6):391-401. Maltepe E, Simon MC. PMID: 9625296.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    81. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech Dev. 1998 Apr; 73(1):117-23. Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA. PMID: 9545558.
      View in: PubMed   Mentions: 111     Fields:    Translation:Animals
    82. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature. 1998 Mar 26; 392(6674):405-8. An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV, Neckers LM. PMID: 9537326.
      View in: PubMed   Mentions: 271     Fields:    Translation:AnimalsCells
    83. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature. 1997 Mar 27; 386(6623):403-7. Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. PMID: 9121557.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    84. Structure of the human type-I interferon gene cluster determined from a YAC clone contig. Genomics. 1994 Aug; 22(3):540-52. Díaz MO, Pomykala HM, Bohlander SK, Maltepe E, Malik K, Brownstein B, Olopade OI. PMID: 8001965.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    85. The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells. Somat Cell Mol Genet. 1993 Sep; 19(5):469-77. Porterfield BW, Pomykala H, Maltepe E, Bohlander SK, Rowley JD, Diaz MO. PMID: 7507266.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    86. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. Genomics. 1992 Oct; 14(2):437-43. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO. PMID: 1385305.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
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