Diane Barber, PhD

InstitutionUniversity of California San Francisco
DepartmentCell and Tissue Biology
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Research 
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    Roles for Intracellular pH Dynamics in Cancer
    NIH/NCI R01CA197855Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Regulation of Epithelial Plasticity
    NIH/NIGMS R01GM116384Jul 1, 2015 - Jun 30, 2019
    Role: Principal Investigator
    Retention of somatic mutations in cancers by changes in pH sensing
    NIH/NCI R21CA178706Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator
    Mechanotransduction in Fibroblast
    NIH/NIGMS R01GM071526Feb 1, 2007 - Sep 30, 2011
    Role: Principal Investigator
    Actions of the Sodium-Hydrogen Exchanger Subtype, NHE1
    NIH/NIGMS R01GM058642Aug 1, 1999 - Nov 30, 2013
    Role: Principal Investigator
    Mechanisms of Receptor Regulated Na+-H+ Exchange
    NIH/NIGMS R01GM047413Jan 1, 1993 - May 31, 2015
    Role: Principal Investigator
    NIH/NIDDK R01DK041371May 1, 1989 - Apr 30, 1993
    Role: Principal Investigator
    NIH/NIDDK R01DK040259Sep 21, 1987 - Dec 31, 2002
    Role: Principal Investigator
    NIH/NIDDK R29DK040259Sep 21, 1987 - Mar 31, 1993
    Role: Principal Investigator
    NIH/NIDDK F32DK007662Sep 1, 1986
    Role: Principal Investigator
    NIH/NIADDK F32AM007662Sep 1, 1985
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rana MK, Aloisio FM, Choi C, Barber D. Formin-dependent TGF-ß signaling for epithelial to mesenchymal transition. Mol Biol Cell. 2018 Apr 18; mbcE17050325. PMID: 29668357.
      View in: PubMed
    2. Tatapudy S, Aloisio F, Barber D, Nystul T. Cell fate decisions: emerging roles for metabolic signals and cell morphology. EMBO Rep. 2017 Dec; 18(12):2105-2118. PMID: 29158350.
      View in: PubMed
    3. Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber D, Kuriyan J, Roose JP. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife. 2017 Sep 27; 6. PMID: 28952923.
      View in: PubMed
    4. White KA, Ruiz DG, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber D. Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins. Sci Signal. 2017 Sep 05; 10(495). PMID: 28874603.
      View in: PubMed
    5. Szpiech ZA, Strauli NB, White KA, Ruiz DG, Jacobson MP, Barber D, Hernandez RD. Prominent features of the amino acid mutation landscape in cancer. PLoS One. 2017; 12(8):e0183273. PMID: 28837668.
      View in: PubMed
    6. Webb BA, Dosey AM, Wittmann T, Kollman JM, Barber D. The glycolytic enzyme phosphofructokinase-1 assembles into filaments. J Cell Biol. 2017 08 07; 216(8):2305-2313. PMID: 28646105.
      View in: PubMed
    7. White KA, Grillo-Hill BK, Barber D. Cancer cell behaviors mediated by dysregulated pH dynamics at a glance. J Cell Sci. 2017 02 15; 130(4):663-669. PMID: 28202602.
      View in: PubMed
    8. Ulmschneider B, Grillo-Hill BK, Benitez M, Azimova DR, Barber D, Nystul TG. Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. J Cell Biol. 2016 Nov 07; 215(3):345-355. PMID: 27821494.
      View in: PubMed
    9. Webb BA, White KA, Grillo-Hill BK, Schönichen A, Choi C, Barber D. A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity. J Biol Chem. 2016 Nov 11; 291(46):24096-24104. PMID: 27650500.
      View in: PubMed
    10. Webb BA, Forouhar F, Szu FE, Seetharaman J, Tong L, Barber D. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature. 2015 Jul 02; 523(7558):111-4. PMID: 25985179; PMCID: PMC4510984.
    11. Grillo-Hill BK, Choi C, Jimenez-Vidal M, Barber D. Increased H? efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife. 2015 Mar 20; 4. PMID: 25793441; PMCID: PMC4392478.
    12. Rana MK, Srivastava J, Yang M, Chen CS, Barber D. Hypoxia increases the abundance but not the assembly of extracellular fibronectin during epithelial cell transdifferentiation. J Cell Sci. 2015 Mar 15; 128(6):1083-9. PMID: 25616899; PMCID: PMC4359919.
    13. LeClaire LL, Rana M, Baumgartner M, Barber D. The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit. J Cell Biol. 2015 Jan 19; 208(2):161-70. PMID: 25601402; PMCID: PMC4298681.
    14. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber D, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Dec 08; 26(6):938. PMID: 28898680.
      View in: PubMed
    15. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber D, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52. PMID: 25446897; PMCID: PMC4254577.
    16. Grillo-Hill BK, Webb BA, Barber D. Ratiometric imaging of pH probes. Methods Cell Biol. 2014; 123:429-48. PMID: 24974041.
      View in: PubMed
    17. Choi CH, Webb BA, Chimenti MS, Jacobson MP, Barber D. pH sensing by FAK-His58 regulates focal adhesion remodeling. J Cell Biol. 2013 Sep 16; 202(6):849-59. PMID: 24043700; PMCID: PMC3776353.
    18. Crevenna AH, Naredi-Rainer N, Schönichen A, Dzubiella J, Barber D, Lamb DC, Wedlich-Söldner R. Electrostatics control actin filament nucleation and elongation kinetics. J Biol Chem. 2013 Apr 26; 288(17):12102-13. PMID: 23486468; PMCID: PMC3636895.
    19. Schönichen A, Webb BA, Jacobson MP, Barber D. Considering protonation as a posttranslational modification regulating protein structure and function. Annu Rev Biophys. 2013; 42:289-314. PMID: 23451893; PMCID: PMC4041481.
    20. Choi CH, Thomason PA, Zaki M, Insall RH, Barber D. Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium. J Biol Chem. 2013 Jan 25; 288(4):2464-74. PMID: 23223240; PMCID: PMC3554915.
    21. Nunomura W, Denker SP, Barber D, Takakuwa Y, Gascard P. Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1). Biochem J. 2012 Sep 15; 446(3):427-35. PMID: 22731252; PMCID: PMC4338608.
    22. Narayanan A, LeClaire LL, Barber D, Jacobson MP. Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation. PLoS Comput Biol. 2011 Nov; 7(11):e1002226. PMID: 22125478; PMCID: PMC3220268.
    23. Haynes J, Srivastava J, Madson N, Wittmann T, Barber D. Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell. 2011 Dec; 22(24):4750-64. PMID: 22031288; PMCID: PMC3237619.
    24. Webb BA, Chimenti M, Jacobson MP, Barber D. Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer. 2011 08 11; 11(9):671-7. PMID: 21833026.
      View in: PubMed
    25. Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin C, Smoot M, Sahasrabudhe S, Barber D, Chanda SK, Ideker T. A human MAP kinase interactome. Nat Methods. 2010 Oct; 7(10):801-5. PMID: 20936779; PMCID: PMC2967489.
    26. Jiménez-Vidal M, Srivastava J, Putney LK, Barber D. Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis. J Biol Chem. 2010 Nov 19; 285(47):36260-6. PMID: 20720019; PMCID: PMC2978553.
    27. Choi CH, Patel H, Barber D. Expression of actin-interacting protein 1 suppresses impaired chemotaxis of Dictyostelium cells lacking the Na+-H+ exchanger NHE1. Mol Biol Cell. 2010 Sep 15; 21(18):3162-70. PMID: 20668166; PMCID: PMC2938382.
    28. Meima ME, Webb BA, Witkowska HE, Barber D. The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors. J Biol Chem. 2009 Sep 25; 284(39):26666-75. PMID: 19622752; PMCID: PMC2785354.
    29. Karydis A, Jimenez-Vidal M, Denker SP, Barber D. Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation. Mol Biol Cell. 2009 Apr; 20(8):2327-36. PMID: 19225158; PMCID: PMC2669038.
    30. Frantz C, Barreiro G, Dominguez L, Chen X, Eddy R, Condeelis J, Kelly MJ, Jacobson MP, Barber D. Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J Cell Biol. 2008 Dec 01; 183(5):865-79. PMID: 19029335; PMCID: PMC2592832.
    31. LeClaire LL, Baumgartner M, Iwasa JH, Mullins RD, Barber D. Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. J Cell Biol. 2008 Aug 25; 182(4):647-54. PMID: 18725535; PMCID: PMC2518704.
    32. Srivastava J, Barber D. Actin co-sedimentation assay; for the analysis of protein binding to F-actin. J Vis Exp. 2008 Mar 28; (13). PMID: 19066573; PMCID: PMC2586866.
    33. Frantz C, Karydis A, Nalbant P, Hahn KM, Barber D. Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. J Cell Biol. 2007 Nov 05; 179(3):403-10. PMID: 17984318; PMCID: PMC2064788.
    34. Meima ME, Mackley JR, Barber D. Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1. Curr Opin Nephrol Hypertens. 2007 Jul; 16(4):365-72. PMID: 17565280.
      View in: PubMed
    35. Srivastava J, Barber D, Jacobson MP. Intracellular pH sensors: design principles and functional significance. Physiology (Bethesda). 2007 Feb; 22:30-9. PMID: 17289928.
      View in: PubMed
    36. Baumgartner M, Sillman AL, Blackwood EM, Srivastava J, Madson N, Schilling JW, Wright JH, Barber D. The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13391-6. PMID: 16938849; PMCID: PMC1569174.
    37. Patel H, Barber D. A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis. J Cell Biol. 2005 Apr 25; 169(2):321-9. PMID: 15851518; PMCID: PMC2171856.
    38. Baumgartner M, Patel H, Barber D. Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C844-50. PMID: 15355855.
      View in: PubMed
    39. Putney LK, Barber D. Expression profile of genes regulated by activity of the Na-H exchanger NHE1. BMC Genomics. 2004 Jul 16; 5(1):46. PMID: 15257760; PMCID: PMC499544.
    40. Putney LK, Barber D. Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J Biol Chem. 2003 Nov 07; 278(45):44645-9. PMID: 12947095.
      View in: PubMed
    41. Lin CY, Varma MG, Joubel A, Madabushi S, Lichtarge O, Barber D. Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. J Biol Chem. 2003 Apr 25; 278(17):15128-35. PMID: 12566440.
      View in: PubMed
    42. Denker SP, Barber D. Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol. 2002 Dec 23; 159(6):1087-96. PMID: 12486114; PMCID: PMC2173980.
    43. Buchan AM, Lin CY, Choi J, Barber D. Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration. J Biol Chem. 2002 Aug 09; 277(32):28431-8. PMID: 12045195.
      View in: PubMed
    44. Denker SP, Barber D. Ion transport proteins anchor and regulate the cytoskeleton. Curr Opin Cell Biol. 2002 Apr; 14(2):214-20. PMID: 11891121.
      View in: PubMed