Jeannette Tenthorey, PhD

Title(s)Assistant Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th Street, #N372B
San Francisco CA 94158
ORCID ORCID Icon0000-0003-0175-080X Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, Berkeley, CAPhD05/2017Molecular and Cell Biology
    Reed College, Portland, ORBA05/2009Biology
    Collapse Awards and Honors
    Howard Hughes Medical Institute2018  - 2026Hanna Gray Fellowship
    American Foundation for AIDS Research2022  - 2023Mathilde Krim Fellowship
    Cold Spring Harbor Retroviruses2022Andy Kaplan Prize
    2021Intersections Science Fellow
    2021Leading Edge Fellow
    Midwinter Conference of Immunologists2017Ray Owen Young Investigator Award
    University of California, Berkeley2014Outstanding Graduate Student Instructor Award
    National Science Foundation2012  - 2015National Science Foundation Graduate Research Fellowship
    University of California, Berkeley2011Berkeley Fellowship for Graduate Study

    Collapse Overview 
    Collapse Overview
    Dr. Tenthorey's lab focuses on understanding how germline-encoded innate immune receptors are built to successfully detect rapidly evolving viral pathogens. Through evolutionary, biochemical and structural dissection, the lab uncovers basic design principles as well as molecular understanding of host-pathogen interactions.
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    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations. bioRxiv. 2024 May 10. Tenthorey JL, Del Banco S, Ramzan I, Klingenberg H, Liu C, Emerman M, Malik HS. PMID: 38765965; PMCID: PMC11100679.
      View in: PubMed   Mentions:
    2. Evolutionary Landscapes of Host-Virus Arms Races. Annu Rev Immunol. 2022 04 26; 40:271-294. Tenthorey JL, Emerman M, Malik HS. PMID: 35080919.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    3. Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races. Elife. 2020 09 15; 9. Tenthorey JL, Young C, Sodeinde A, Emerman M, Malik HS. PMID: 32930662; PMCID: PMC7492085.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    4. Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants. Proc Natl Acad Sci U S A. 2020 08 04; 117(31):18832-18839. Duxbury Z, Wang S, MacKenzie CI, Tenthorey JL, Zhang X, Huh SU, Hu L, Hill L, Ngou PM, Ding P, Chen J, Ma Y, Guo H, Castel B, Moschou PN, Bernoux M, Dodds PN, Vance RE, Jones JDG. PMID: 32709746; PMCID: PMC7414095.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    5. NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma. J Exp Med. 2020 07 06; 217(7). Tenthorey JL, Chavez RA, Thompson TW, Deets KA, Vance RE, Rauch I. PMID: 32342103; PMCID: PMC7336302.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    6. Cryo-EM studies of NAIP-NLRC4 inflammasomes. Methods Enzymol. 2019; 625:177-204. Haloupek N, Grob P, Tenthorey J, Vance RE, Nogales E. PMID: 31455527; PMCID: PMC7025759.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    7. The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion. Science. 2017 11 17; 358(6365):888-893. Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE. PMID: 29146805; PMCID: PMC5842810.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    8. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 04 18; 46(4):649-659. Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE. PMID: 28410991; PMCID: PMC5476318.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    9. NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J Exp Med. 2016 05 02; 213(5):657-65. Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE. PMID: 27045008; PMCID: PMC4854734.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    10. An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition. J Biol Chem. 2015 Oct 02; 290(40):24614-25. Girard JR, Tenthorey JL, Morgan DO. PMID: 26306044; PMCID: PMC4591839.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Mol Cell. 2014 Apr 10; 54(1):17-29. Tenthorey JL, Kofoed EM, Daugherty MD, Malik HS, Vance RE. PMID: 24657167; PMCID: PMC3988258.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    12. RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol. 2009 Jun; 10(6):655-64. Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA. PMID: 19448632; PMCID: PMC2693356.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    13. Diagnostic markers for early detection of ovarian cancer. Clin Cancer Res. 2008 Feb 15; 14(4):1065-72. Visintin I, Feng Z, Longton G, Ward DC, Alvero AB, Lai Y, Tenthorey J, Leiser A, Flores-Saaib R, Yu H, Azori M, Rutherford T, Schwartz PE, Mor G. PMID: 18258665.
      View in: PubMed   Mentions: 141     Fields:    Translation:Humans
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