Jennifer Mitchell, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1999 Graduate Division (Neuroscience)
    Reed CollegeB.A.1992Department of Psychology

    Collapse Overview 
    Collapse Overview
    I conduct translational neuroscience research that rests at the intersection of psychology, pharmacology, and genetics. My work is focused on understanding the neural mechanisms responsible for decision-making, impulsivity, and other mechanisms in relation to drug and alcohol abuse, and on developing novel treatment strategies for these disorders. Our group uses a combination of behavioral pharmacology, genetics, electrophysiology, and fMRI to conduct research in both animal and human models of choice, impulsivity, compulsivity, and other factors that may regulate hazardous drug and alcohol use and decision-making in humans.

    DoD Awarded Grants

    W81XWH-14-2-0143 Institute for Translational Neuroscience 2013
    W81XWH-13-2-0075 Institute for Translational Neuroscience 2012
    W81XWH-12-2-0048 Institute for Translational Neuroscience 2011
    W81XWH-11-2-0145 Institute for Translational Neuroscience 2010
    W81XWH-07-1-0431 Human Functional Imaging of Central Nervous System Opioids in Alcohol Reward 2007

    Collapse Research 
    Collapse Research Activities and Funding
    Metabotropic glutamate receptor function in cocaine
    NIH/NIDA F32DA014735Oct 1, 2001 - Jul 31, 2004
    Role: Principal Investigator

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    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sosa E, Chen D, Rojas EJ, Hennebold JD, Peters KA, Wu Z, Lam TN, Mitchell JM, Sukhwani M, Tailor RC, Meistrich ML, Orwig KE, Shetty G, Clark AT. Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. Nat Commun. 2018 12 17; 9(1):5339. PMID: 30559363.
      View in: PubMed
    2. Mitchell JM, Weinstein D, Vega T, Kayser AS. Dopamine, time perception, and future time perspective. Psychopharmacology (Berl). 2018 Oct; 235(10):2783-2793. PMID: 30027496.
      View in: PubMed
    3. Kayser AS, Vega T, Weinstein D, Peters J, Mitchell JM. Right inferior frontal cortex activity correlates with tolcapone responsivity in problem and pathological gamblers. Neuroimage Clin. 2017; 13:339-348. PMID: 28066708.
      View in: PubMed
    4. Mitchell JM, Arcuni PA, Weinstein D, Woolley JD. Intranasal Oxytocin Selectively Modulates Social Perception, Craving, and Approach Behavior in Subjects With Alcohol Use Disorder. J Addict Med. 2016 May-Jun; 10(3):182-9. PMID: 27159342.
      View in: PubMed
    5. Kayser AS, Mitchell JM, Weinstein D, Frank MJ. Dopamine, locus of control, and the exploration-exploitation tradeoff. Neuropsychopharmacology. 2015 Jan; 40(2):454-62. PMID: 25074639; PMCID: PMC4443960.
    6. Mitchell JM, Margolis EB, Coker AR, Allen DC, Fields HL. Intra-VTA deltorphin, but not DPDPE, induces place preference in ethanol-drinking rats: distinct DOR-1 and DOR-2 mechanisms control ethanol consumption and reward. Alcohol Clin Exp Res. 2014 Jan; 38(1):195-203. PMID: 24033469.
      View in: PubMed
    7. Mitchell JM, O'Neil JP, Jagust WJ, Fields HL. Catechol-O-methyltransferase genotype modulates opioid release in decision circuitry. Clin Transl Sci. 2013 Oct; 6(5):400-3. PMID: 24127930.
      View in: PubMed
    8. Kayser AS, Allen DC, Navarro-Cebrian A, Mitchell JM, Fields HL. Dopamine, corticostriatal connectivity, and intertemporal choice. J Neurosci. 2012 Jul 04; 32(27):9402-9. PMID: 22764248.
      View in: PubMed
    9. Mitchell JM, Margolis EB, Coker AR, Fields HL. Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area. Behav Neurosci. 2012 Aug; 126(4):515-22. PMID: 22708955.
      View in: PubMed
    10. Mitchell JM, Teague CH, Kayser AS, Bartlett SE, Fields HL. Varenicline decreases alcohol consumption in heavy-drinking smokers. Psychopharmacology (Berl). 2012 Oct; 223(3):299-306. PMID: 22547331; PMCID: PMC3438402.
    11. Mitchell JM, Grossman LE, Coker AR, Messing RO. The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers. J Clin Psychopharmacol. 2012 Apr; 32(2):269-72. PMID: 22367657.
      View in: PubMed
    12. Mitchell JM, O'Neil JP, Janabi M, Marks SM, Jagust WJ, Fields HL. Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens. Sci Transl Med. 2012 Jan 11; 4(116):116ra6. PMID: 22238334.
      View in: PubMed
    13. Margolis EB, Mitchell JM, Hjelmstad GO, Fields HL. A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons. J Physiol. 2011 Sep 01; 589(17):4229-42. PMID: 21690191; PMCID: PMC3180580.
    14. Boettiger CA, Kelley EA, Mitchell JM, D'Esposito M, Fields HL. Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Pharmacol Biochem Behav. 2009 Sep; 93(3):291-9. PMID: 19258022; PMCID: PMC2729462.
    15. Margolis EB, Fields HL, Hjelmstad GO, Mitchell JM. Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. J Neurosci. 2008 Nov 26; 28(48):12672-81. PMID: 19036960.
      View in: PubMed
    16. Mitchell JM, Bergren LJ, Chen KS, Rowbotham MC, Fields HL. Naltrexone aversion and treatment efficacy are greatest in humans and rats that actively consume high levels of alcohol. Neurobiol Dis. 2009 Jan; 33(1):72-80. PMID: 18955144.
      View in: PubMed
    17. Margolis EB, Mitchell JM, Ishikawa J, Hjelmstad GO, Fields HL. Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. J Neurosci. 2008 Sep 03; 28(36):8908-13. PMID: 18768684.
      View in: PubMed
    18. Boettiger CA, Mitchell JM, Tavares VC, Robertson M, Joslyn G, D'Esposito M, Fields HL. Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype. J Neurosci. 2007 Dec 26; 27(52):14383-91. PMID: 18160646.
      View in: PubMed
    19. Mitchell JM, Fields HL, White RL, Meadoff TM, Joslyn G, Rowbotham MC. The Asp40 mu-opioid receptor allele does not predict naltrexone treatment efficacy in heavy drinkers. J Clin Psychopharmacol. 2007 Feb; 27(1):112-5. PMID: 17224736.
      View in: PubMed
    20. Mitchell JM, Bergren LJ, Chen KS, Fields HL. Cholecystokinin is necessary for the expression of morphine conditioned place preference. Pharmacol Biochem Behav. 2006 Dec; 85(4):787-95. PMID: 17196636.
      View in: PubMed
    21. Mitchell JM, Tavares VC, Fields HL, D'Esposito M, Boettiger CA. Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls. Neuropsychopharmacology. 2007 Feb; 32(2):439-49. PMID: 17047667.
      View in: PubMed
    22. Mitchell JM, Fields HL, D'Esposito M, Boettiger CA. Impulsive responding in alcoholics. Alcohol Clin Exp Res. 2005 Dec; 29(12):2158-69. PMID: 16385186.
      View in: PubMed
    23. Mitchell JM, Liang MT, Fields HL. A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats. Psychopharmacology (Berl). 2005 Nov; 182(3):384-92. PMID: 16001119.
      View in: PubMed
    24. Mitchell JM, Cunningham CL, Mark GP. Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake. Behav Neurosci. 2005 Apr; 119(2):464-72. PMID: 15839792.
      View in: PubMed
    25. Paladini CA, Mitchell JM, Williams JT, Mark GP. Cocaine self-administration selectively decreases noradrenergic regulation of metabotropic glutamate receptor-mediated inhibition in dopamine neurons. J Neurosci. 2004 Jun 02; 24(22):5209-15. PMID: 15175391.
      View in: PubMed
    26. Valverde O, Mantamadiotis T, Torrecilla M, Ugedo L, Pineda J, Bleckmann S, Gass P, Kretz O, Mitchell JM, Sch├╝tz G, Maldonado R. Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology. 2004 Jun; 29(6):1122-33. PMID: 15029152.
      View in: PubMed