Elyssa Margolis, PhD
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Title(s) | Associate Professor, Neurology |
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School | School of Medicine |
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Address | 675 Nelson Rising Lane San Francisco CA 94158
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Phone | 415-353-4793 |
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vCard | Download vCard |
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Title(s) | UCSF Weill Institute for Neurosciences |
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Biography University of California, San Francisco | Postdoctoral Studies | | Graduate Division | University of California, San Francisco | Ph.D. | 2003 | Graduate Division (Bioengineering) |
Overview We study the Neurobiology of Addiction, and specifically the neural circuits and G Protein Coupled Receptor function involved in drug reinforcement and seeking. We use a wide range of preclinical tools including whole cell electrophysiology, conventional anatomical techniques, behavioral and neural pharmacology, and in vivo and ex vivo optogenetics. For more information visit http://elyssabmargolis.com/
Research Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Ventral Tegmental Area GABA, glutamate, and glutamate-GABA neurons are heterogeneous in their electrophysiological and pharmacological properties. Eur J Neurosci. 2021 Feb 22.
Miranda-Barrientos J, Chambers I, Mongia S, Liu B, Wang HL, Mateo-Semidey GE, Margolis EB, Zhang S, Morales M. PMID: 33619763.
View in: PubMed Mentions: Fields:
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Differential effects of novel kappa opioid receptor antagonists on dopamine neurons using acute brain slice electrophysiology. PLoS One. 2020; 15(12):e0232864.
Margolis EB, Wallace TL, Van Orden LJ, Martin WJ. PMID: 33373369.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System. eNeuro. 2020 Jul/Aug; 7(5).
PMID: 32747458.
View in: PubMed Mentions: Fields:
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Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. Mol Pharmacol. 2020 08; 98(2):96-108.
Fricker LD, Margolis EB, Gomes I, Devi LA. PMID: 32487735.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimals
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Biased signaling by endogenous opioid peptides. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11820-11828.
Gomes I, Sierra S, Lueptow L, Gupta A, Gouty S, Margolis EB, Cox BM, Devi LA. PMID: 32393639.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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A Midbrain Circuit that Mediates Headache Aversiveness in Rats. Cell Rep. 2019 09 10; 28(11):2739-2747.e4.
Waung MW, Margolis EB, Charbit AR, Fields HL. PMID: 31509737.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion. Neurochem Int. 2019 10; 129:104504.
Margolis EB, Karkhanis AN. PMID: 31301327.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in the rat. J Comp Neurol. 2019 04 01; 527(5):916-941.
Breton JM, Charbit AR, Snyder BJ, Fong PTK, Dias EV, Himmels P, Lock H, Margolis EB. PMID: 30393861.
View in: PubMed Mentions: 15 Fields: Translation: AnimalsCells
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Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties. Nat Neurosci. 2018 08; 21(8):1072-1083.
Saunders BT, Richard JM, Margolis EB, Janak PH. PMID: 30038277.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor. Neuropharmacology. 2017 Sep 01; 123:420-432.
Margolis EB, Fujita W, Devi LA, Fields HL. PMID: 28645621.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Ventral tegmental area: cellular heterogeneity, connectivity and behaviour. Nat Rev Neurosci. 2017 02; 18(2):73-85.
PMID: 28053327.
View in: PubMed Mentions: 131 Fields: Translation: AnimalsCells
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Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area. Neuropharmacology. 2016 11; 110(Pt A):386-395.
PMID: 27475082.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Mu Opioid Receptor Actions in the Lateral Habenula. PLoS One. 2016; 11(7):e0159097.
PMID: 27427945.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 04 26; 9(425):ra43.
PMID: 27117253.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimalsCells
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Understanding opioid reward. Trends Neurosci. 2015 Apr; 38(4):217-25.
PMID: 25637939.
View in: PubMed Mentions: 78 Fields: Translation: HumansAnimalsCells
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Direct bidirectional µ-opioid control of midbrain dopamine neurons. J Neurosci. 2014 Oct 29; 34(44):14707-16.
PMID: 25355223.
View in: PubMed Mentions: 30 Fields: Translation: AnimalsCells
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Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17.
PMID: 25339743.
View in: PubMed Mentions: 61 Fields: Translation: AnimalsCells
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New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system. J Neurosci. 2013 Nov 06; 33(45):17569-76.
PMID: 24198347.
View in: PubMed Mentions: 57 Fields: Translation: AnimalsCells
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Intra-VTA deltorphin, but not DPDPE, induces place preference in ethanol-drinking rats: distinct DOR-1 and DOR-2 mechanisms control ethanol consumption and reward. Alcohol Clin Exp Res. 2014 Jan; 38(1):195-203.
PMID: 24033469.
View in: PubMed Mentions: 10 Fields: Translation: Animals
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Opioid modulation of ventral pallidal afferents to ventral tegmental area neurons. J Neurosci. 2013 Apr 10; 33(15):6454-9.
PMID: 23575843.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Identification of rat ventral tegmental area GABAergic neurons. PLoS One. 2012; 7(7):e42365.
PMID: 22860119.
View in: PubMed Mentions: 61 Fields: Translation: AnimalsCells
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Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area. Behav Neurosci. 2012 Aug; 126(4):515-22.
PMID: 22708955.
View in: PubMed Mentions: 3 Fields: Translation: Animals
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A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons. J Physiol. 2011 Sep 01; 589(17):4229-42.
PMID: 21690191.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Nucleus accumbens medium spiny neurons target non-dopaminergic neurons in the ventral tegmental area. J Neurosci. 2011 May 25; 31(21):7811-6.
PMID: 21613494.
View in: PubMed Mentions: 80 Fields: Translation: AnimalsCells
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Reliability in the identification of midbrain dopamine neurons. PLoS One. 2010 Dec 09; 5(12):e15222.
PMID: 21151605.
View in: PubMed Mentions: 38 Fields: Translation: HumansAnimalsCells
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Substance P inhibits GABAB receptor signalling in the ventral tegmental area. J Physiol. 2010 May 01; 588(Pt 9):1541-9.
Xia YF, Margolis EB, Hjelmstad GO. PMID: 20231139.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons. J Neurosci. 2010 Jan 06; 30(1):218-29.
Dobi A, Margolis EB, Wang HL, Harvey BK, Morales M. PMID: 20053904.
View in: PubMed Mentions: 85 Fields: Translation: AnimalsCells
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Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption. J Neurosci. 2008 Nov 26; 28(48):12672-81.
Margolis EB, Fields HL, Hjelmstad GO, Mitchell JM. PMID: 19036960.
View in: PubMed Mentions: 47 Fields: Translation: Animals
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Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition. J Neurosci. 2008 Sep 03; 28(36):8908-13.
Margolis EB, Mitchell JM, Ishikawa J, Hjelmstad GO, Fields HL. PMID: 18768684.
View in: PubMed Mentions: 114 Fields: Translation: AnimalsCells
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Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annu Rev Neurosci. 2007; 30:289-316.
Fields HL, Hjelmstad GO, Margolis EB, Nicola SM. PMID: 17376009.
View in: PubMed Mentions: 204 Fields: Translation: HumansAnimalsCells
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The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? J Physiol. 2006 Dec 15; 577(Pt 3):907-24.
Margolis EB, Lock H, Hjelmstad GO, Fields HL. PMID: 16959856.
View in: PubMed Mentions: 246 Fields: Translation: AnimalsCells
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Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2938-42.
Margolis EB, Lock H, Chefer VI, Shippenberg TS, Hjelmstad GO, Fields HL. PMID: 16477003.
View in: PubMed Mentions: 148 Fields: Translation: AnimalsCells
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Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons. J Neurophysiol. 2005 Jun; 93(6):3086-93.
Margolis EB, Hjelmstad GO, Bonci A, Fields HL. PMID: 15615834.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J Neurosci. 2003 Nov 05; 23(31):9981-6.
Margolis EB, Hjelmstad GO, Bonci A, Fields HL. PMID: 14602811.
View in: PubMed Mentions: 112 Fields: Translation: AnimalsCells
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Year | Publications |
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2003 | 1 | 2004 | 1 | 2006 | 2 | 2007 | 1 | 2008 | 2 | 2010 | 3 | 2011 | 2 | 2012 | 2 | 2013 | 3 | 2014 | 2 | 2015 | 1 | 2016 | 3 | 2017 | 2 | 2018 | 2 | 2019 | 2 | 2020 | 4 | 2021 | 1 |
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Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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