Lorenzo Pasquini, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #001
San Francisco CA 94158
ORCID ORCID Icon0000-0002-7899-7061 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse education and training
    Pompeu Fabra University, Barcelona, SpainVisiting scholar2022Computational neuroscience
    Memory and Aging Center, University of California, San Francisco, San FranciscoPostdoc2022Neuroimaging of dementia
    Technische Universität München, MunichPhD09/2016Neuroimaging of dementia
    Brain Institute, Natal (Brazil)Visiting scholar03/2016Neuroimaging
    King's College London, LondonVisiting scholar06/2015Epidemiology
    Ludwig Maximilians Universität, MunichMS09/2015Public Health
    Université Paris Sud, ParisErasmus student09/2008Neuroscience
    Ludwig Maximilians Universität, MunichDiploma09/2011Biology
    Collapse awards and honors
    NEW-B2022  - 2022NEW-B travel award to SfN
    NIH-NIA2022  - nowR00 Pathway to Independence Award
    Humboldt Foundation2022  - 2025Feodor Lynen Research Fellowship
    NIH-NIA2020  - 2022K99 Pathway to Independence Award
    Big Data Neuroscience 20172017  - 2017Travel Fellowsip
    Society of Neuroscience2017  - 2017Minisymposium
    AAIC2016  - 2016Travel Fellowship
    German Academic Foundation2014  - 2016PhD Fellowship

    Collapse Overview 
    Collapse overview
    I was a postdoctoral fellow at the Memory and Aging center in 2016, where I used fMRI and autonomic physiology to study the neural basis of social-emotional functions in older adults and patients with frontotemporal dementia.

    I joined Neuroscape as a faculty in 2022, where I explore the neural basis of emotional well-being in older adults using multimodal, simultaneous fMRI and autonomic physiology recordings.

    A primary aim of my research is to develop tailored interventions, either behavioral (e.g. closed-loop meditation) or pharmacological (e.g. psilocybin), to target those brain systems that support emotions and social behavior in older adults. In my work, I combine sophisticated data analysis techniques, such as dynamic connectivity and brain connectivity gradients, to to better understand how the brain and the body interact to support emotional well-being in older adults.

    Since 2023, I have been in the scientific advisory board of AWEAR, an early-stage startup developing wearable EEG technology.

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self. Imaging Neuroscience. 2025 Apr 16; 3:imag_a_00541. Pasquini PL, Simon SA, Gallen GC, Kettner KH, Roseman RL, Gazzaley GA, Carhart-Harris CR, Timmermann TC. .
      View in: Publisher Site   Mentions:
    2. Reply to Letter to the Editor: "Psychedelics in Older Adults: Difficulties of a Clear Therapeutic Evidence". Am J Geriatr Psychiatry. 2025 Jan; 33(1):118-119. Kettner H, Roseman L, Gazzaley A, Carhart-Harris RL, Pasquini L. PMID: 39393967.
      View in: PubMed   Mentions:    Fields:    
    3. Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes. Brain. 2024 Sep 03; 147(9):3032-3047. Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, Humphrey J, Gitler AD, Miller BL, Pollard KS, Ward ME, Seeley WW. PMID: 38940350; PMCID: PMC11370792.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    4. Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self. bioRxiv. 2024 Aug 12. Pasquini L, Simon AJ, Gallen CL, Kettner H, Roseman L, Gazzaley A, Carhart-Harris RL, Timmermann C. PMID: 38464275; PMCID: PMC10925211.
      View in: PubMed   Mentions:
    5. Effects of Psychedelics in Older Adults: A Prospective Cohort Study. Am J Geriatr Psychiatry. 2024 Sep; 32(9):1047-1059. Kettner H, Roseman L, Gazzaley A, Carhart-Harris RL, Pasquini L. PMID: 38849218; PMCID: PMC11316630.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Improvements in well-being following naturalistic psychedelic use and underlying mechanisms of change in older adults: A prospective cohort study. Res Sq. 2024 Mar 08. Kettner H, Roseman L, Gazzaley A, Carhart-Harris R, Pasquini L. PMID: 38496492; PMCID: PMC10942571.
      View in: PubMed   Mentions:
    7. Functional network collapse in neurodegenerative disease. bioRxiv. 2023 Dec 06. Brown JA, Lee AJ, Fernhoff K, Pistone T, Pasquini L, Wise AB, Staffaroni AM, Luisa Mandelli M, Lee SE, Boxer AL, Rankin KP, Rabinovici GD, Luisa Gorno Tempini M, Rosen HJ, Kramer JH, Miller BL, Seeley WW, Alzheimer’s Disease Neuroimaging Initiative (ADNI). PMID: 38106054; PMCID: PMC10723363.
      View in: PubMed   Mentions:
    8. FTLD targets brain regions expressing recently evolved genes. medRxiv. 2023 Oct 28. Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, Humphrey J, Gitler AD, Miller BL, Pollard KS, Ward ME, Seeley WW. PMID: 37961381; PMCID: PMC10635220.
      View in: PubMed   Mentions: 1  
    9. Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum. Ann Neurol. 2023 10; 94(4):632-646. Zhang L, Flagan TM, Häkkinen S, Chu SA, Brown JA, Lee AJ, Pasquini L, Mandelli ML, Gorno-Tempini ML, Sturm VE, Yokoyama JS, Appleby BS, Cobigo Y, Dickerson BC, Domoto-Reilly K, Geschwind DH, Ghoshal N, Graff-Radford NR, Grossman M, Hsiung GR, Huey ED, Kantarci K, Lario Lago A, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Ramos EM, Roberson ED, Tartaglia MC, Toga AW, Weintraub S, Wszolek ZK, Forsberg LK, Heuer HW, Boeve BF, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Lee SE, ARTFL/LEFFTDS/ALLFTD Consortia. PMID: 37431188; PMCID: PMC10727479.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia. JAMA Neurol. 2023 04 01; 80(4):377-387. Friedberg A, Pasquini L, Diggs R, Glaubitz EA, Lopez L, Illán-Gala I, Iaccarino L, La Joie R, Mundada N, Knudtson M, Neylan K, Brown J, Allen IE, Rankin KP, Bonham LW, Yokoyama JS, Ramos EM, Geschwind DH, Spina S, Grinberg LT, Miller ZA, Kramer JH, Rosen H, Gorno-Tempini ML, Rabinovici G, Seeley WW, Miller BL. PMID: 36848111; PMCID: PMC9972248.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    11. Dynamic autonomic nervous system states arise during emotions and manifest in basal physiology. Psychophysiology. 2023 04; 60(4):e14218. Pasquini L, Noohi F, Veziris CR, Kosik EL, Holley SR, Lee A, Brown JA, Roy ARK, Chow TE, Allen I, Rosen HJ, Kramer JH, Miller BL, Saggar M, Seeley WW, Sturm VE. PMID: 36371680; PMCID: PMC10038867.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 09; 8(9):928-939. Pasquini L, Fryer SL, Eisendrath SJ, Segal ZV, Lee AJ, Brown JA, Saggar M, Mathalon DH. PMID: 36754677; PMCID: PMC10150583.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. A dynamic gradient architecture generates brain activity states. Neuroimage. 2022 11 01; 261:119526. Brown JA, Lee AJ, Pasquini L, Seeley WW. PMID: 35914669; PMCID: PMC9585924.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    14. Convergent regional brain abnormalities in behavioral variant frontotemporal dementia: A neuroimaging meta-analysis of 73 studies. Alzheimers Dement (Amst). 2022; 14(1):e12318. Kamalian A, Khodadadifar T, Saberi A, Masoudi M, Camilleri JA, Eickhoff CR, Zarei M, Pasquini L, Laird AR, Fox PT, Eickhoff SB, Tahmasian M. PMID: 35664889; PMCID: PMC9148620.
      View in: PubMed   Mentions: 11  
    15. Local neurodegeneration and global connectivity adaptation across the FTD-AD spectrum. Alzheimer's & Dementia. 2021 Dec 31; 17(S6). Brown BJ, Lee LA, Pasquini PL, Friedberg FA, Rabinovici RG, Kramer KJ, Tempini TM, Rosen RH, Miller MB, Seeley SW. .
      View in: Publisher Site   Mentions:
    16. A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. Brain Pathol. 2021 03; 31(2):267-282. Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, Franca Resende EP, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SY, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT. PMID: 33314436; PMCID: PMC7946775.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia. Cereb Cortex. 2020 09 03; 30(10):5387-5399. Pasquini L, Nana AL, Toller G, Brown JA, Deng J, Staffaroni A, Kim EJ, Hwang JL, Li L, Park Y, Gaus SE, Allen I, Sturm VE, Spina S, Grinberg LT, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW. PMID: 32500143; PMCID: PMC7566683.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    18. Subacute effects of the psychedelic ayahuasca on the salience and default mode networks. J Psychopharmacol. 2020 06; 34(6):623-635. Pasquini L, Palhano-Fontes F, Araujo DB. PMID: 32255395.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    19. Questions and controversies in the study of time-varying functional connectivity in resting fMRI. Netw Neurosci. 2020; 4(1):30-69. Lurie DJ, Kessler D, Bassett DS, Betzel RF, Breakspear M, Kheilholz S, Kucyi A, Liégeois R, Lindquist MA, McIntosh AR, Poldrack RA, Shine JM, Thompson WH, Bielczyk NZ, Douw L, Kraft D, Miller RL, Muthuraman M, Pasquini L, Razi A, Vidaurre D, Xie H, Calhoun VD. PMID: 32043043; PMCID: PMC7006871.
      View in: PubMed   Mentions: 252  
    20. State and trait characteristics of anterior insula time-varying functional connectivity. Neuroimage. 2020 03; 208:116425. Pasquini L, Toller G, Staffaroni A, Brown JA, Deng J, Lee A, Kurcyus K, Shdo SM, Allen I, Sturm VE, Cobigo Y, Borghesani V, Battistella G, Gorno-Tempini ML, Rankin KP, Kramer J, Rosen HH, Miller BL, Seeley WW. PMID: 31805382; PMCID: PMC7225015.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Human subsystems of medial temporal lobes extend locally to amygdala nuclei and globally to an allostatic-interoceptive system. Neuroimage. 2020 02 15; 207:116404. Ruiz-Rizzo AL, Beissner F, Finke K, Müller HJ, Zimmer C, Pasquini L, Sorg C. PMID: 31783114.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. Progress update from the hippocampal subfields group. Alzheimers Dement (Amst). 2019 Dec; 11:439-449. Olsen RK, Carr VA, Daugherty AM, La Joie R, Amaral RSC, Amunts K, Augustinack JC, Bakker A, Bender AR, Berron D, Boccardi M, Bocchetta M, Burggren AC, Chakravarty MM, Chételat G, de Flores R, DeKraker J, Ding SL, Geerlings MI, Huang Y, Insausti R, Johnson EG, Kanel P, Kedo O, Kennedy KM, Keresztes A, Lee JK, Lindenberger U, Mueller SG, Mulligan EM, Ofen N, Palombo DJ, Pasquini L, Pluta J, Raz N, Rodrigue KM, Schlichting ML, Lee Shing Y, Stark CEL, Steve TA, Suthana NA, Wang L, Werkle-Bergner M, Yushkevich PA, Yu Q, Wisse LEM, Hippocampal Subfields Group. PMID: 31245529; PMCID: PMC6581847.
      View in: PubMed   Mentions: 28  
    23. Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer's Disease Stages. J Alzheimers Dis Rep. 2019 May 15; 3(1):103-112. Pasquini L, Rahmani F, Maleki-Balajoo S, La Joie R, Zarei M, Sorg C, Drzezga A, Tahmasian M. PMID: 31259307; PMCID: PMC6597961.
      View in: PubMed   Mentions: 26  
    24. Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia. Neuroimage Clin. 2019; 23:101822. Butler PM, Chiong W, Perry DC, Miller ZA, Gennatas ED, Brown JA, Pasquini L, Karydas A, Dokuru D, Coppola G, Sturm VE, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW. PMID: 31003069; PMCID: PMC6475809.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study. Hum Brain Mapp. 2021 09; 42(13):4134-4143. Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V. PMID: 30697878; PMCID: PMC8357005.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    26. Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology. Acta Neuropathol. 2019 01; 137(1):27-46. Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW. PMID: 30511086; PMCID: PMC6339592.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    27. Neurological signs as early determinants of dementia and predictors of mortality among older adults in Latin America: a 10/66 study using the NEUROEX assessment. BMC Neurol. 2018 Oct 03; 18(1):163. Pasquini L, Llibre Guerra J, Prince M, Chua KC, Prina AM. PMID: 30285663; PMCID: PMC6168999.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    28. Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease. J Cereb Blood Flow Metab. 2019 07; 39(7):1314-1325. Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C. PMID: 29431005; PMCID: PMC6668525.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Decoupling of Local Metabolic Activity and Functional Connectivity Links to Amyloid in Alzheimer's Disease. J Alzheimers Dis. 2018; 64(2):405-415. Scherr M, Pasquini L, Benson G, Nuttall R, Gruber M, Neitzel J, Brandl F, Sorg C, Alzheimer’s Disease Neuroimaging Initiative. PMID: 29843243.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    30. Individual Correspondence of Amyloid-β and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease. J Alzheimers Dis. 2017; 58(3):763-773. Pasquini L, Benson G, Grothe MJ, Utz L, Myers NE, Yakushev I, Grimmer T, Scherr M, Sorg C, Alzheimer’s Disease Neuroimaging Initiative. PMID: 28482640.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    31. Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum. Alzheimers Dement (Amst). 2016; 5:35-42. Nuttall R, Pasquini L, Scherr M, Sorg C. PMID: 28054026; PMCID: PMC5198881.
      View in: PubMed   Mentions: 9  
    32. Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer's Disease. Front Neurol. 2016; 7:132. Ortner M, Pasquini L, Barat M, Alexopoulos P, Grimmer T, Förster S, Diehl-Schmid J, Kurz A, Förstl H, Zimmer C, Wohlschläger A, Sorg C, Peters H. PMID: 27698649; PMCID: PMC5027206.
      View in: PubMed   Mentions: 18  
    33. GLOBAL AND LOCAL INTERACTIONS BETWEEN AMYLOID-B PATHOLOGY AND INTRINSIC CONNECTIVITY ALONG THE SPECTRUM OF ALZHEIMER’S DISEASE. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p306. Pasquini PL, Benson BG, Scherr SM, Yakushev YI, Grimmer GT, Myers MN, Grothe GM, Sorg SC, Initiative IA. .
      View in: Publisher Site   Mentions:
    34. AMYLOID PATHOLOGY DECOUPLES LOCAL MEAN SYNAPTIC ACTIVITY FROM ITS INTER-REGIONAL FUNCTIONAL CONNECTIVITY. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p275. Sorg SC, Pasquini PL, Yakushev YI, Grimmer GT, Scherr SM. .
      View in: Publisher Site   Mentions:
    35. Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia. J Alzheimers Dis. 2016; 51(1):313-26. Pasquini L, Scherr M, Tahmasian M, Myers NE, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Akhrif A, Wohlschläger AM, Riedl V, Sorg C. PMID: 26836175.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease. Neurology. 2015 May 12; 84(19):1956-63. Tahmasian M, Pasquini L, Scherr M, Meng C, Förster S, Mulej Bratec S, Shi K, Yakushev I, Schwaiger M, Grimmer T, Diehl-Schmid J, Riedl V, Sorg C, Drzezga A. PMID: 25878180.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    37. Link between hippocampus' raised local and eased global intrinsic connectivity in AD. Alzheimers Dement. 2015 May; 11(5):475-84. Pasquini L, Scherr M, Tahmasian M, Meng C, Myers NE, Ortner M, Mühlau M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschläger AM, Riedl V, Sorg C. PMID: 25043909.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    38. Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease. Cereb Cortex. 2015 Dec; 25(12):4678-88. Koch K, Myers NE, Göttler J, Pasquini L, Grimmer T, Förster S, Manoliu A, Neitzel J, Kurz A, Förstl H, Riedl V, Wohlschläger AM, Drzezga A, Sorg C. PMID: 24996404; PMCID: PMC4635914.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    39. WITHIN-PATIENT CORRESPONDENCE OF AMYLOID-B AND INTRINSIC NETWORK CONNECTIVITY IN ALZHEIMER'S DISEASE. Alzheimer's & Dementia. 2014 Jul 1; 10(4):p158-p159. Sorg SC, Wohlschläger WA, Drzezga DA, Kurz KA, Förstl FH, Pasquini PL, Myers MN, Grimmer GT, Riedl RV. .
      View in: Publisher Site   Mentions:
    40. Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons. Brain Connect. 2014 Jun; 4(5):323-36. Pasquini L, Tonch A, Plant C, Zherdin A, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschäger A, Riedl V, Sorg C. PMID: 24689864; PMCID: PMC4064725.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease. Brain. 2014 Jul; 137(Pt 7):2052-64. Myers N, Pasquini L, Göttler J, Grimmer T, Koch K, Ortner M, Neitzel J, Mühlau M, Förster S, Kurz A, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Drzezga A, Sorg C. PMID: 24771519; PMCID: PMC4065018.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
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