 Lorenzo Pasquini, PhD
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| Title | Postdoctoral Scholar |
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| Institution | University of California San Francisco |
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| Department | Neurology |
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| Address | 675 Nelson Rising Lane
San Francisco CA 94158
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| vCard | Download vCard |
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 Biography | Technische Universität München, Munich | PhD | 09/2016 | Neuroimaging of dementia | | Brain Institute, Natal (Brazil) | Visiting scholar | 03/2016 | Neuroimaging | | King's College London, London | Visiting scholar | 06/2015 | Epidemiology | | Ludwig Maximilians Universität, Munich | MS | 09/2015 | Public Health | | Université Paris Sud, Paris | Erasmus student | 09/2008 | Neuroscience | | Ludwig Maximilians Universität, Munich | Diploma | 09/2011 | Biology |
| Society of Neuroscience | 2017
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| 2017 | Minisymposium | | Big Data Neuroscience 2017 | 2017
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| 2017 | Travel Fellowsip | | AAIC | 2016
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| 2016 | Travel Fellowship | | German Academic Foundation | 2014
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| 2016 | PhD Fellowship |
Overview I have joined the Seeley lab in November 2016 as a postdoctoral fellow. My background is in Neuroscience and Public Health. I obtained my PhD from the Technical University of Munich, where I investigated large-scale brain network dysfunctions in Alzheimer’s disease, with a specific focus on multimodal neuroimaging and intrinsic activity of the medial temporal lobes. Among other projects, I have collaborated with the Psychiatry Department of King’s College London on a project investigating neurological determinants of dementia in low and middle income countries (10/66 Research Group), and with the Brain Institute in Natal on a fMRI project investigating the effects of the psychedelic substance Ayahuasca on brain activity. My main interests are to investigate the link between neuropathology and neuroimaging, and to develop subject tailored neuroimaging biomarkers for frontotemporal dementia.
Bibliographic
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Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C. Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease. J Cereb Blood Flow Metab. 2018 Jan 01; 271678X18759182. PMID: 29431005.
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Pasquini L, Benson G, Grothe MJ, Utz L, Myers NE, Yakushev I, Grimmer T, Scherr M, Sorg C. Individual Correspondence of Amyloid-ß and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease. J Alzheimers Dis. 2017; 58(3):763-773. PMID: 28482640.
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Nuttall R, Pasquini L, Scherr M, Sorg C. Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum. Alzheimers Dement (Amst). 2016; 5:35-42. PMID: 28054026.
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Ortner M, Pasquini L, Barat M, Alexopoulos P, Grimmer T, Förster S, Diehl-Schmid J, Kurz A, Förstl H, Zimmer C, Wohlschläger A, Sorg C, Peters H. Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer's Disease. Front Neurol. 2016; 7:132. PMID: 27698649.
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Pasquini L, Scherr M, Tahmasian M, Myers NE, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Akhrif A, Wohlschläger AM, Riedl V, Sorg C. Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia. J Alzheimers Dis. 2016; 51(1):313-26. PMID: 26836175.
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Tahmasian M, Pasquini L, Scherr M, Meng C, Förster S, Mulej Bratec S, Shi K, Yakushev I, Schwaiger M, Grimmer T, Diehl-Schmid J, Riedl V, Sorg C, Drzezga A. The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease. Neurology. 2015 May 12; 84(19):1956-63. PMID: 25878180.
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Pasquini L, Scherr M, Tahmasian M, Meng C, Myers NE, Ortner M, Mühlau M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschläger AM, Riedl V, Sorg C. Link between hippocampus' raised local and eased global intrinsic connectivity in AD. Alzheimers Dement. 2015 May; 11(5):475-84. PMID: 25043909.
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Koch K, Myers NE, Göttler J, Pasquini L, Grimmer T, Förster S, Manoliu A, Neitzel J, Kurz A, Förstl H, Riedl V, Wohlschläger AM, Drzezga A, Sorg C. Disrupted Intrinsic Networks Link Amyloid-ß Pathology and Impaired Cognition in Prodromal Alzheimer's Disease. Cereb Cortex. 2015 Dec; 25(12):4678-88. PMID: 24996404; PMCID: PMC4635914 [Available on 12/01/16].
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Pasquini L, Tonch A, Plant C, Zherdin A, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschäger A, Riedl V, Sorg C. Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons. Brain Connect. 2014 Jun; 4(5):323-36. PMID: 24689864; PMCID: PMC4064725.
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Myers N, Pasquini L, Göttler J, Grimmer T, Koch K, Ortner M, Neitzel J, Mühlau M, Förster S, Kurz A, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Drzezga A, Sorg C. Within-patient correspondence of amyloid-ß and intrinsic network connectivity in Alzheimer's disease. Brain. 2014 Jul; 137(Pt 7):2052-64. PMID: 24771519; PMCID: PMC4065018.
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