Lorenzo Pasquini, PhD
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Title(s) | Postdoctoral Scholar, Neurology |
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School | School of Medicine |
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Address | 675 Nelson Rising Lane San Francisco CA 94158
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Phone | -- |
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ORCID
.gif) | 0000-0002-7899-7061  |
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vCard | Download vCard |
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Title(s) | UCSF Weill Institute for Neurosciences |
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Biography Technische Universität München, Munich | PhD | 09/2016 | Neuroimaging of dementia | Brain Institute, Natal (Brazil) | Visiting scholar | 03/2016 | Neuroimaging | King's College London, London | Visiting scholar | 06/2015 | Epidemiology | Ludwig Maximilians Universität, Munich | MS | 09/2015 | Public Health | Université Paris Sud, Paris | Erasmus student | 09/2008 | Neuroscience | Ludwig Maximilians Universität, Munich | Diploma | 09/2011 | Biology |
NIH-NIA | 2020
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| now | K99/R00 Pathway to Independence Award | Society of Neuroscience | 2017
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| 2017 | Minisymposium | Big Data Neuroscience 2017 | 2017
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| 2017 | Travel Fellowsip | AAIC | 2016
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| 2016 | Travel Fellowship | German Academic Foundation | 2014
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| 2016 | PhD Fellowship |
Overview I have joined the Seeley lab in November 2016 as a postdoctoral fellow. My background is in Neuroscience and Public Health. I obtained my PhD from the Technical University of Munich, where I investigated large-scale brain network dysfunctions in Alzheimer’s disease, with a specific focus on multimodal neuroimaging and intrinsic activity of the medial temporal lobes. Among other projects, I have collaborated with the Psychiatry Department of King’s College London on a project investigating neurological determinants of dementia in low and middle income countries (10/66 Research Group), and with the Brain Institute in Natal on a fMRI project investigating the effects of the psychedelic substance Ayahuasca on brain activity. My main interests are to investigate the link between neuropathology and neuroimaging, and to develop subject tailored neuroimaging biomarkers for frontotemporal dementia.
Frontotemporal dementia, Alzheimer's disease, Dynamic functional connectivity, Neuroimaging biomarker, Insula, Social-emotional function, Von Economo neurons, Autonomic nervous system physiology, Empathy, Emotions, Psychedelic assisted psychotherapy
ORNG Applications Bibliographic
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. Brain Pathol. 2020 Dec 12; e12924.
Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, De Paula Franca Resende E, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SY, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT. PMID: 33314436.
View in: PubMed Mentions: Fields:
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Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia. Cereb Cortex. 2020 Sep 03; 30(10):5387-5399.
Pasquini L, Nana AL, Toller G, Brown JA, Deng J, Staffaroni A, Kim EJ, Hwang JL, Li L, Park Y, Gaus SE, Allen I, Sturm VE, Spina S, Grinberg LT, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW. PMID: 32500143.
View in: PubMed Mentions: Fields:
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Subacute effects of the psychedelic ayahuasca on the salience and default mode networks. J Psychopharmacol. 2020 06; 34(6):623-635.
Pasquini L, Palhano-Fontes F, Araujo DB. PMID: 32255395.
View in: PubMed Mentions: 1 Fields:
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Questions and controversies in the study of time-varying functional connectivity in resting fMRI. Netw Neurosci. 2020; 4(1):30-69.
Lurie DJ, Kessler D, Bassett DS, Betzel RF, Breakspear M, Kheilholz S, Kucyi A, Liégeois R, Lindquist MA, McIntosh AR, Poldrack RA, Shine JM, Thompson WH, Bielczyk NZ, Douw L, Kraft D, Miller RL, Muthuraman M, Pasquini L, Razi A, Vidaurre D, Xie H, Calhoun VD. PMID: 32043043.
View in: PubMed Mentions:
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State and trait characteristics of anterior insula time-varying functional connectivity. Neuroimage. 2020 03; 208:116425.
Pasquini L, Toller G, Staffaroni A, Brown JA, Deng J, Lee A, Kurcyus K, Shdo SM, Allen I, Sturm VE, Cobigo Y, Borghesani V, Battistella G, Gorno-Tempini ML, Rankin KP, Kramer J, Rosen HH, Miller BL, Seeley WW. PMID: 31805382.
View in: PubMed Mentions: 1 Fields:
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Human subsystems of medial temporal lobes extend locally to amygdala nuclei and globally to an allostatic-interoceptive system. Neuroimage. 2020 02 15; 207:116404.
Ruiz-Rizzo AL, Beissner F, Finke K, Müller HJ, Zimmer C, Pasquini L, Sorg C. PMID: 31783114.
View in: PubMed Mentions: Fields:
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Progress update from the hippocampal subfields group. Alzheimers Dement (Amst). 2019 Dec; 11:439-449.
Olsen RK, Carr VA, Daugherty AM, La Joie R, Amaral RSC, Amunts K, Augustinack JC, Bakker A, Bender AR, Berron D, Boccardi M, Bocchetta M, Burggren AC, Chakravarty MM, Chételat G, de Flores R, DeKraker J, Ding SL, Geerlings MI, Huang Y, Insausti R, Johnson EG, Kanel P, Kedo O, Kennedy KM, Keresztes A, Lee JK, Lindenberger U, Mueller SG, Mulligan EM, Ofen N, Palombo DJ, Pasquini L, Pluta J, Raz N, Rodrigue KM, Schlichting ML, Lee Shing Y, Stark CEL, Steve TA, Suthana NA, Wang L, Werkle-Bergner M, Yushkevich PA, Yu Q, Wisse LEM. PMID: 31245529.
View in: PubMed Mentions:
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Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer's Disease Stages. J Alzheimers Dis Rep. 2019 May 15; 3(1):103-112.
Pasquini L, Rahmani F, Maleki-Balajoo S, La Joie R, Zarei M, Sorg C, Drzezga A, Tahmasian M. PMID: 31259307.
View in: PubMed Mentions:
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Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study. Hum Brain Mapp. 2019 Jan 30.
Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V. PMID: 30697878.
View in: PubMed Mentions: 3 Fields:
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Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology. Acta Neuropathol. 2019 01; 137(1):27-46.
Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW. PMID: 30511086.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Neurological signs as early determinants of dementia and predictors of mortality among older adults in Latin America: a 10/66 study using the NEUROEX assessment. BMC Neurol. 2018 Oct 03; 18(1):163.
Pasquini L, Llibre Guerra J, Prince M, Chua KC, Prina AM. PMID: 30285663.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease. J Cereb Blood Flow Metab. 2019 07; 39(7):1314-1325.
Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C. PMID: 29431005.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Decoupling of Local Metabolic Activity and Functional Connectivity Links to Amyloid in Alzheimer's Disease. J Alzheimers Dis. 2018; 64(2):405-415.
Scherr M, Pasquini L, Benson G, Nuttall R, Gruber M, Neitzel J, Brandl F, Sorg C. PMID: 29843243.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Individual Correspondence of Amyloid-ß and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease. J Alzheimers Dis. 2017; 58(3):763-773.
Pasquini L, Benson G, Grothe MJ, Utz L, Myers NE, Yakushev I, Grimmer T, Scherr M, Sorg C. PMID: 28482640.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum. Alzheimers Dement (Amst). 2016; 5:35-42.
Nuttall R, Pasquini L, Scherr M, Sorg C. PMID: 28054026.
View in: PubMed Mentions:
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Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer's Disease. Front Neurol. 2016; 7:132.
Ortner M, Pasquini L, Barat M, Alexopoulos P, Grimmer T, Förster S, Diehl-Schmid J, Kurz A, Förstl H, Zimmer C, Wohlschläger A, Sorg C, Peters H. PMID: 27698649.
View in: PubMed Mentions:
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GLOBAL AND LOCAL INTERACTIONS BETWEEN AMYLOID-B PATHOLOGY AND INTRINSIC CONNECTIVITY ALONG THE SPECTRUM OF ALZHEIMER’S DISEASE. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p306.
Lorenzo Pasquini, Gloria Benson, Martin Scherr, Igor Yakushev, Timo Grimmer, Nicholas Myers, Michel J. Grothe, Christian Sorg, Alzheimer's Disease Neuroimaging Initiative. .
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AMYLOID PATHOLOGY DECOUPLES LOCAL MEAN SYNAPTIC ACTIVITY FROM ITS INTER-REGIONAL FUNCTIONAL CONNECTIVITY. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p275.
Christian Sorg, Lorenzo Pasquini, Igor Yakushev, Timo Grimmer, Martin Scherr. .
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Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia. J Alzheimers Dis. 2016; 51(1):313-26.
Pasquini L, Scherr M, Tahmasian M, Myers NE, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Akhrif A, Wohlschläger AM, Riedl V, Sorg C. PMID: 26836175.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease. Neurology. 2015 May 12; 84(19):1956-63.
Tahmasian M, Pasquini L, Scherr M, Meng C, Förster S, Mulej Bratec S, Shi K, Yakushev I, Schwaiger M, Grimmer T, Diehl-Schmid J, Riedl V, Sorg C, Drzezga A. PMID: 25878180.
View in: PubMed Mentions: 22 Fields: Translation: Humans
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Link between hippocampus' raised local and eased global intrinsic connectivity in AD. Alzheimers Dement. 2015 May; 11(5):475-84.
Pasquini L, Scherr M, Tahmasian M, Meng C, Myers NE, Ortner M, Mühlau M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschläger AM, Riedl V, Sorg C. PMID: 25043909.
View in: PubMed Mentions: 26 Fields: Translation: Humans
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Disrupted Intrinsic Networks Link Amyloid-ß Pathology and Impaired Cognition in Prodromal Alzheimer's Disease. Cereb Cortex. 2015 Dec; 25(12):4678-88.
Koch K, Myers NE, Göttler J, Pasquini L, Grimmer T, Förster S, Manoliu A, Neitzel J, Kurz A, Förstl H, Riedl V, Wohlschläger AM, Drzezga A, Sorg C. PMID: 24996404.
View in: PubMed Mentions: 32 Fields: Translation: Humans
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WITHIN-PATIENT CORRESPONDENCE OF AMYLOID-B AND INTRINSIC NETWORK CONNECTIVITY IN ALZHEIMER'S DISEASE. Alzheimer's & Dementia. 2014 Jul 1; 10(4):p158-p159.
Christian Sorg, Afra M. Wohlschläger, Alexander Drzezga, Alexander Kurz, Hans Förstl, Lorenzo Pasquini, Nicholas Myers, Timo Grimmer, Valentin Riedl. .
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Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons. Brain Connect. 2014 Jun; 4(5):323-36.
Pasquini L, Tonch A, Plant C, Zherdin A, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschäger A, Riedl V, Sorg C. PMID: 24689864.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Within-patient correspondence of amyloid-ß and intrinsic network connectivity in Alzheimer's disease. Brain. 2014 Jul; 137(Pt 7):2052-64.
Myers N, Pasquini L, Göttler J, Grimmer T, Koch K, Ortner M, Neitzel J, Mühlau M, Förster S, Kurz A, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Drzezga A, Sorg C. PMID: 24771519.
View in: PubMed Mentions: 42 Fields: Translation: Humans
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Year | Publications |
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2014 | 5 | 2015 | 1 | 2016 | 5 | 2017 | 1 | 2018 | 4 | 2019 | 5 | 2020 | 4 |
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This graph shows the number and percent of publications by field.
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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