Lorenzo Pasquini, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone--
ORCID ORCID Icon0000-0002-7899-7061 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Technische Universität München, MunichPhD09/2016Neuroimaging of dementia
    Brain Institute, Natal (Brazil)Visiting scholar03/2016Neuroimaging
    King's College London, LondonVisiting scholar06/2015Epidemiology
    Ludwig Maximilians Universität, MunichMS09/2015Public Health
    Université Paris Sud, ParisErasmus student09/2008Neuroscience
    Ludwig Maximilians Universität, MunichDiploma09/2011Biology
    Collapse Awards and Honors
    NIH-NIA2020  - nowK99/R00 Pathway to Independence Award
    Society of Neuroscience2017  - 2017Minisymposium
    Big Data Neuroscience 20172017  - 2017Travel Fellowsip
    AAIC2016  - 2016Travel Fellowship
    German Academic Foundation2014  - 2016PhD Fellowship

    Collapse Overview 
    Collapse Overview
    I have joined the Seeley lab in November 2016 as a postdoctoral fellow. My background is in Neuroscience and Public Health. I obtained my PhD from the Technical University of Munich, where I investigated large-scale brain network dysfunctions in Alzheimer’s disease, with a specific focus on multimodal neuroimaging and intrinsic activity of the medial temporal lobes. Among other projects, I have collaborated with the Psychiatry Department of King’s College London on a project investigating neurological determinants of dementia in low and middle income countries (10/66 Research Group), and with the Brain Institute in Natal on a fMRI project investigating the effects of the psychedelic substance Ayahuasca on brain activity. My main interests are to investigate the link between neuropathology and neuroimaging, and to develop subject tailored neuroimaging biomarkers for frontotemporal dementia.
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. Brain Pathol. 2021 03; 31(2):267-282. Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, Franca Resende EP, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SY, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT. PMID: 33314436; PMCID: PMC7946775.
      View in: PubMed   Mentions: 1     Fields:    
    2. Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia. Cereb Cortex. 2020 09 03; 30(10):5387-5399. Pasquini L, Nana AL, Toller G, Brown JA, Deng J, Staffaroni A, Kim EJ, Hwang JL, Li L, Park Y, Gaus SE, Allen I, Sturm VE, Spina S, Grinberg LT, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW. PMID: 32500143; PMCID: PMC7566683.
      View in: PubMed   Mentions: 6     Fields:    
    3. Subacute effects of the psychedelic ayahuasca on the salience and default mode networks. J Psychopharmacol. 2020 06; 34(6):623-635. Pasquini L, Palhano-Fontes F, Araujo DB. PMID: 32255395.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    4. Questions and controversies in the study of time-varying functional connectivity in resting fMRI. Netw Neurosci. 2020; 4(1):30-69. Lurie DJ, Kessler D, Bassett DS, Betzel RF, Breakspear M, Kheilholz S, Kucyi A, Liégeois R, Lindquist MA, McIntosh AR, Poldrack RA, Shine JM, Thompson WH, Bielczyk NZ, Douw L, Kraft D, Miller RL, Muthuraman M, Pasquini L, Razi A, Vidaurre D, Xie H, Calhoun VD. PMID: 32043043; PMCID: PMC7006871.
      View in: PubMed   Mentions: 52  
    5. State and trait characteristics of anterior insula time-varying functional connectivity. Neuroimage. 2020 03; 208:116425. Pasquini L, Toller G, Staffaroni A, Brown JA, Deng J, Lee A, Kurcyus K, Shdo SM, Allen I, Sturm VE, Cobigo Y, Borghesani V, Battistella G, Gorno-Tempini ML, Rankin KP, Kramer J, Rosen HH, Miller BL, Seeley WW. PMID: 31805382; PMCID: PMC7225015.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Human subsystems of medial temporal lobes extend locally to amygdala nuclei and globally to an allostatic-interoceptive system. Neuroimage. 2020 02 15; 207:116404. Ruiz-Rizzo AL, Beissner F, Finke K, Müller HJ, Zimmer C, Pasquini L, Sorg C. PMID: 31783114.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Progress update from the hippocampal subfields group. Alzheimers Dement (Amst). 2019 Dec; 11:439-449. Olsen RK, Carr VA, Daugherty AM, La Joie R, Amaral RSC, Amunts K, Augustinack JC, Bakker A, Bender AR, Berron D, Boccardi M, Bocchetta M, Burggren AC, Chakravarty MM, Chételat G, de Flores R, DeKraker J, Ding SL, Geerlings MI, Huang Y, Insausti R, Johnson EG, Kanel P, Kedo O, Kennedy KM, Keresztes A, Lee JK, Lindenberger U, Mueller SG, Mulligan EM, Ofen N, Palombo DJ, Pasquini L, Pluta J, Raz N, Rodrigue KM, Schlichting ML, Lee Shing Y, Stark CEL, Steve TA, Suthana NA, Wang L, Werkle-Bergner M, Yushkevich PA, Yu Q, Wisse LEM, Hippocampal Subfields Group. PMID: 31245529; PMCID: PMC6581847.
      View in: PubMed   Mentions: 8  
    8. Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer's Disease Stages. J Alzheimers Dis Rep. 2019 May 15; 3(1):103-112. Pasquini L, Rahmani F, Maleki-Balajoo S, La Joie R, Zarei M, Sorg C, Drzezga A, Tahmasian M. PMID: 31259307; PMCID: PMC6597961.
      View in: PubMed   Mentions: 6  
    9. Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia. Neuroimage Clin. 2019; 23:101822. Butler PM, Chiong W, Perry DC, Miller ZA, Gennatas ED, Brown JA, Pasquini L, Karydas A, Dokuru D, Coppola G, Sturm VE, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW. PMID: 31003069; PMCID: PMC6475809.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study. Hum Brain Mapp. 2021 09; 42(13):4134-4143. Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V. PMID: 30697878; PMCID: PMC8357005.
      View in: PubMed   Mentions: 8     Fields:    
    11. Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology. Acta Neuropathol. 2019 01; 137(1):27-46. Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW. PMID: 30511086; PMCID: PMC6339592.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    12. Neurological signs as early determinants of dementia and predictors of mortality among older adults in Latin America: a 10/66 study using the NEUROEX assessment. BMC Neurol. 2018 Oct 03; 18(1):163. Pasquini L, Llibre Guerra J, Prince M, Chua KC, Prina AM. PMID: 30285663; PMCID: PMC6168999.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease. J Cereb Blood Flow Metab. 2019 07; 39(7):1314-1325. Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C. PMID: 29431005; PMCID: PMC6668525.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Decoupling of Local Metabolic Activity and Functional Connectivity Links to Amyloid in Alzheimer's Disease. J Alzheimers Dis. 2018; 64(2):405-415. Scherr M, Pasquini L, Benson G, Nuttall R, Gruber M, Neitzel J, Brandl F, Sorg C, Alzheimer’s Disease Neuroimaging Initiative. PMID: 29843243.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Individual Correspondence of Amyloid-β and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease. J Alzheimers Dis. 2017; 58(3):763-773. Pasquini L, Benson G, Grothe MJ, Utz L, Myers NE, Yakushev I, Grimmer T, Scherr M, Sorg C, Alzheimer’s Disease Neuroimaging Initiative. PMID: 28482640.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    16. Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum. Alzheimers Dement (Amst). 2016; 5:35-42. Nuttall R, Pasquini L, Scherr M, Sorg C. PMID: 28054026; PMCID: PMC5198881.
      View in: PubMed   Mentions: 6  
    17. Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer's Disease. Front Neurol. 2016; 7:132. Ortner M, Pasquini L, Barat M, Alexopoulos P, Grimmer T, Förster S, Diehl-Schmid J, Kurz A, Förstl H, Zimmer C, Wohlschläger A, Sorg C, Peters H. PMID: 27698649; PMCID: PMC5027206.
      View in: PubMed   Mentions: 4  
    18. GLOBAL AND LOCAL INTERACTIONS BETWEEN AMYLOID-B PATHOLOGY AND INTRINSIC CONNECTIVITY ALONG THE SPECTRUM OF ALZHEIMER’S DISEASE. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p306. Pasquini PL, Benson BG, Scherr SM, Yakushev YI, Grimmer GT, Myers MN, Grothe GM, Sorg SC, Initiative IA. .
      View in: Publisher Site   Mentions:
    19. AMYLOID PATHOLOGY DECOUPLES LOCAL MEAN SYNAPTIC ACTIVITY FROM ITS INTER-REGIONAL FUNCTIONAL CONNECTIVITY. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p275. Sorg SC, Pasquini PL, Yakushev YI, Grimmer GT, Scherr SM. .
      View in: Publisher Site   Mentions:
    20. Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia. J Alzheimers Dis. 2016; 51(1):313-26. Pasquini L, Scherr M, Tahmasian M, Myers NE, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Akhrif A, Wohlschläger AM, Riedl V, Sorg C. PMID: 26836175.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease. Neurology. 2015 May 12; 84(19):1956-63. Tahmasian M, Pasquini L, Scherr M, Meng C, Förster S, Mulej Bratec S, Shi K, Yakushev I, Schwaiger M, Grimmer T, Diehl-Schmid J, Riedl V, Sorg C, Drzezga A. PMID: 25878180.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    22. Link between hippocampus' raised local and eased global intrinsic connectivity in AD. Alzheimers Dement. 2015 May; 11(5):475-84. Pasquini L, Scherr M, Tahmasian M, Meng C, Myers NE, Ortner M, Mühlau M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschläger AM, Riedl V, Sorg C. PMID: 25043909.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    23. Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease. Cereb Cortex. 2015 Dec; 25(12):4678-88. Koch K, Myers NE, Göttler J, Pasquini L, Grimmer T, Förster S, Manoliu A, Neitzel J, Kurz A, Förstl H, Riedl V, Wohlschläger AM, Drzezga A, Sorg C. PMID: 24996404; PMCID: PMC4635914.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    24. WITHIN-PATIENT CORRESPONDENCE OF AMYLOID-B AND INTRINSIC NETWORK CONNECTIVITY IN ALZHEIMER'S DISEASE. Alzheimer's & Dementia. 2014 Jul 1; 10(4):p158-p159. Sorg SC, Wohlschläger WA, Drzezga DA, Kurz KA, Förstl FH, Pasquini PL, Myers MN, Grimmer GT, Riedl RV. .
      View in: Publisher Site   Mentions:
    25. Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons. Brain Connect. 2014 Jun; 4(5):323-36. Pasquini L, Tonch A, Plant C, Zherdin A, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschäger A, Riedl V, Sorg C. PMID: 24689864; PMCID: PMC4064725.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease. Brain. 2014 Jul; 137(Pt 7):2052-64. Myers N, Pasquini L, Göttler J, Grimmer T, Koch K, Ortner M, Neitzel J, Mühlau M, Förster S, Kurz A, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Drzezga A, Sorg C. PMID: 24771519; PMCID: PMC4065018.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
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