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A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion. Anesthesiology. 2012 Feb; 116(2):334-9.
Ruan W, French D, Wong A, Drasner K, Wu AH. PMID: 22273855.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila). 2011 Nov; 49(9):801-9.
French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH. PMID: 21981684.
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PubMed Mentions:
28 Fields:
Translation:
HumansPHPublic Health
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Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose. Clin Toxicol (Phila). 2011 Apr; 49(4):340-4.
French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH. PMID: 21563913.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Anesthetic effects on the developing nervous system: if you aren't concerned, you haven't been paying attention. Anesthesiology. 2010 Jul; 113(1):10-2.
Drasner K. PMID: 20508495.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Safety of ultrasound-guided regional anesthesia. Anesthesiology. 2010 Jun; 112(6):1538-9.
Gray AT, Drasner K. PMID: 20502123.
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PubMed Mentions: Fields:
Translation:
Humans
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Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):140-4.
Hiller DB, Di Gregorio G, Kelly K, Ripper R, Edelman L, Boumendjel R, Drasner K, Weinberg GL. PMID: 20301820.
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PubMed Mentions:
17 Fields:
Translation:
Animals
-
ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):152-61.
Neal JM, Bernards CM, Butterworth JF, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL. PMID: 20216033.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimals
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Local anesthetic systemic toxicity: a historical perspective. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):162-6.
Drasner K. PMID: 20216034.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Continuous spinal analgesia for labor and delivery: a born-again technique? Anesthesiology. 2008 Feb; 108(2):184-6.
Drasner K, Smiley R. PMID: 18212561.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Epidural chloroprocaine-standard of care for postpartum bilateral tubal ligation. Anesth Analg. 2005 Oct; 101(4):1241.
Drasner K. PMID: 16192557.
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PubMed Mentions: Fields:
Translation:
Humans
-
Chloroprocaine spinal anesthesia: back to the future? Anesth Analg. 2005 Feb; 100(2):549-552.
Drasner K. PMID: 15673892.
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PubMed Mentions: Fields:
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Thoracic epidural anesthesia: asleep at the wheal? Anesth Analg. 2004 Aug; 99(2):578-9.
Drasner K. PMID: 15271742.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
Sodium bisulfite: scapegoat for chloroprocaine neurotoxicity? Anesthesiology. 2004 Jan; 100(1):85-91.
Taniguchi M, Bollen AW, Drasner K. PMID: 14695728.
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PubMed Mentions:
9 Fields:
Translation:
Animals
-
Comparative spinal neurotoxicity of prilocaine and lidocaine. Anesthesiology. 2002 Nov; 97(5):1250-3.
Kishimoto T, Bollen AW, Drasner K. PMID: 12411812.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Local anesthetic neurotoxicity: clinical injury and strategies that may minimize risk. Reg Anesth Pain Med. 2002 Nov-Dec; 27(6):576-80.
Drasner K. PMID: 12430107.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat. Anesthesiology. 2001 May; 94(5):876-81.
Hashimoto K, Hampl KF, Nakamura Y, Bollen AW, Feiner J, Drasner K. PMID: 11388541.
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PubMed Mentions:
6 Fields:
Translation:
Animals
-
Low concentrations of halothane increase response to a noxious thermal stimulus and attenuate the antinociceptive effect of intraventricular but not intrathecal morphine. Anesthesiology. 2001 Feb; 94(2):298-302.
Drasner K. PMID: 11176095.
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PubMed Mentions:
1 Fields:
Translation:
Animals
-
Comparative toxicity of glucose and lidocaine administered intrathecally in the rat. Reg Anesth Pain Med. 1998 Sep-Oct; 23(5):444-50.
Hashimoto K, Sakura S, Bollen AW, Ciriales R, Drasner K. PMID: 9773695.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients. Anesthesiology. 1998 Sep; 89(3):633-41.
Freedman JM, Li DK, Drasner K, Jaskela MC, Larsen B, Wi S. PMID: 9743399.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther. 1998 May; 285(2):413-21.
Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD. PMID: 9580578.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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A comparative study of low-dose hyperbaric spinal lidocaine 0.5% versus 5% for continuous spinal anesthesia. Reg Anesth Pain Med. 1998 Mar-Apr; 23(2):164-9.
Chan VW, Garcia J, Al-Kaisy A, Drasner K. PMID: 9570605.
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PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. Anesthesiology. 1998 Mar; 88(3):629-33.
Hampl KF, Heinzmann-Wiedmer S, Luginbuehl I, Harms C, Seeberger M, Schneider MC, Drasner K. PMID: 9523805.
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PubMed Mentions:
16 Fields:
Translation:
HumansCTClinical Trials
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The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine. Anesthesiology. 1997 Oct; 87(4):771-8.
Sakura S, Sumi M, Sakaguchi Y, Saito Y, Kosaka Y, Drasner K. PMID: 9357877.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Lidocaine spinal anesthesia: a vanishing therapeutic index? Anesthesiology. 1997 Sep; 87(3):469-72.
Drasner K. PMID: 9316947.
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PubMed Mentions:
5 Fields:
Translation:
Humans
-
Intrathecal catheterization in the rat. Improved technique for morphologic analysis of drug-induced injury. Anesthesiology. 1996 Nov; 85(5):1184-9.
Sakura S, Hashimoto K, Bollen AW, Ciriales R, Drasner K. PMID: 8916837.
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PubMed Mentions:
12 Fields:
Translation:
Animals
-
A similar incidence of transient neurologic symptoms after spinal anesthesia with 2% and 5% lidocaine. Anesth Analg. 1996 Nov; 83(5):1051-4.
Hampl KF, Schneider MC, Pargger H, Gut J, Drewe J, Drasner K. PMID: 8895284.
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PubMed Mentions:
16 Fields:
Translation:
HumansCTClinical Trials
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Spontaneous intracranial hypotension: a series. Anesthesiology. 1996 Oct; 85(4):923-5.
Weitz SR, Drasner K. PMID: 8873565.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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[Neurologic sequelae of spinal anesthesia: local anesthetic toxicity]. Masui. 1996 Jul; 45(7):846-51.
Sakura S, Drasner K. PMID: 8741475.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesth Analg. 1995 Aug; 81(2):338-46.
Sakura S, Bollen AW, Ciriales R, Drasner K. PMID: 7618726.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Local anesthetic test dose as a predictor of effective epidural opioid analgesia. Anesthesiology. 1995 Jul; 83(1):96-100.
Weitz SR, Drasner K. PMID: 7605025.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33.
Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. PMID: 7879930.
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PubMed Mentions:
27 Fields:
Translation:
HumansCTClinical Trials
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The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat. Anesthesiology. 1995 Jan; 82(1):236-40.
Sakura S, Chan VW, Ciriales R, Drasner K. PMID: 7832306.
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PubMed Mentions:
7 Fields:
Translation:
Animals
-
Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat. Anesthesiology. 1994 Apr; 80(4):847-52.
Drasner K, Sakura S, Chan VW, Bollen AW, Ciriales R. PMID: 8024139.
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PubMed Mentions:
8 Fields:
Translation:
Animals
-
Models for local anesthetic toxicity from continuous spinal anesthesia. Reg Anesth. 1993 Nov-Dec; 18(6 Suppl):434-8.
Drasner K. PMID: 8110644.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Cauda equina syndrome following intended epidural anesthesia. Anesthesiology. 1992 Sep; 77(3):582-5.
Drasner K, Rigler ML, Sessler DI, Stoller ML. PMID: 1519794.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Distribution of catheter-injected local anesthetic in a model of the subarachnoid space. Anesthesiology. 1991 Oct; 75(4):684-92.
Rigler ML, Drasner K. PMID: 1928779.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Lumbar intrathecal morphine alters activity of putative nociceptive modulatory neurons in rostral ventromedial medulla. Brain Res. 1991 May 24; 549(2):338-41.
Heinricher MM, Drasner K. PMID: 1884228.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Hypotension during transfusion of autologous blood. Anesthesiology. 1991 Mar; 74(3):624-8.
Miller AC, Scherba-Krugliak L, Toy PT, Drasner K. PMID: 2001042.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg. 1991 Mar; 72(3):275-81.
Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, Bohner D. PMID: 1994754.
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PubMed Mentions:
72 Fields:
Translation:
Humans
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Is chronic ethanol consumption associated with tolerance to intrathecal lidocaine in the rat? Anesth Analg. 1990 May; 70(5):489-92.
Fassoulaki A, Drasner K, Eger EI. PMID: 2331064.
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PubMed Mentions: Fields:
Translation:
Animals
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Preoperative laboratory testing of children undergoing elective surgery. Anesth Analg. 1990 Feb; 70(2):176-80.
O'Connor ME, Drasner K. PMID: 2301750.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla. Brain Res. 1989 Oct 30; 501(1):116-28.
Fang FG, Haws CM, Drasner K, Williamson A, Fields HL. PMID: 2572306.
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PubMed Mentions:
22 Fields:
Translation:
Animals
-
Intrathecal morphine reduces the minimum alveolar concentration of halothane in humans. Anesthesiology. 1988 Sep; 69(3):310-2.
Drasner K, Bernards CM, Ozanne GM. PMID: 2843066.
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Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat. Pain. 1988 Mar; 32(3):309-312.
Drasner K, Fields HL. PMID: 3362566.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells