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Kenneth Drasner, MD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentAnesthesia
Address1001 Potrero Ave, SFGH 5
San Francisco CA 94110
Phone415-206-3248
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    LOCAL ANESTHETIC NEUROTOXICITY
    NIH/NIGMS R01GM051887Apr 1, 1996 - Mar 31, 2001
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ruan W, French D, Wong A, Drasner K, Wu AH. A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion. Anesthesiology. 2012 Feb; 116(2):334-9. PMID: 22273855.
      View in: PubMed
    2. French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila). 2011 Nov; 49(9):801-9. PMID: 21981684.
      View in: PubMed
    3. French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH. Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose. Clin Toxicol (Phila). 2011 Apr; 49(4):340-4. PMID: 21563913.
      View in: PubMed
    4. Drasner K. Anesthetic effects on the developing nervous system: if you aren't concerned, you haven't been paying attention. Anesthesiology. 2010 Jul; 113(1):10-2. PMID: 20508495.
      View in: PubMed
    5. Gray AT, Drasner K. Safety of ultrasound-guided regional anesthesia. Anesthesiology. 2010 Jun; 112(6):1538-9. PMID: 20502123.
      View in: PubMed
    6. Hiller DB, Di Gregorio G, Kelly K, Ripper R, Edelman L, Boumendjel R, Drasner K, Weinberg GL. Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):140-4. PMID: 20301820.
      View in: PubMed
    7. Neal JM, Bernards CM, Butterworth JF, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):152-61. PMID: 20216033.
      View in: PubMed
    8. Drasner K. Local anesthetic systemic toxicity: a historical perspective. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):162-6. PMID: 20216034.
      View in: PubMed
    9. Drasner K, Smiley R. Continuous spinal analgesia for labor and delivery: a born-again technique? Anesthesiology. 2008 Feb; 108(2):184-6. PMID: 18212561.
      View in: PubMed
    10. Drasner K. Chloroprocaine spinal anesthesia: back to the future? Anesth Analg. 2005 Feb; 100(2):549-52. PMID: 15673892.
      View in: PubMed
    11. Drasner K. Thoracic epidural anesthesia: asleep at the wheal? Anesth Analg. 2004 Aug; 99(2):578-9. PMID: 15271742.
      View in: PubMed
    12. Taniguchi M, Bollen AW, Drasner K. Sodium bisulfite: scapegoat for chloroprocaine neurotoxicity? Anesthesiology. 2004 Jan; 100(1):85-91. PMID: 14695728.
      View in: PubMed
    13. Kishimoto T, Bollen AW, Drasner K. Comparative spinal neurotoxicity of prilocaine and lidocaine. Anesthesiology. 2002 Nov; 97(5):1250-3. PMID: 12411812.
      View in: PubMed
    14. Drasner K. Local anesthetic neurotoxicity: clinical injury and strategies that may minimize risk. Reg Anesth Pain Med. 2002 Nov-Dec; 27(6):576-80. PMID: 12430107.
      View in: PubMed
    15. Hashimoto K, Hampl KF, Nakamura Y, Bollen AW, Feiner J, Drasner K. Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat. Anesthesiology. 2001 May; 94(5):876-81. PMID: 11388541.
      View in: PubMed
    16. Drasner K. Low concentrations of halothane increase response to a noxious thermal stimulus and attenuate the antinociceptive effect of intraventricular but not intrathecal morphine. Anesthesiology. 2001 Feb; 94(2):298-302. PMID: 11176095.
      View in: PubMed
    17. Hashimoto K, Sakura S, Bollen AW, Ciriales R, Drasner K. Comparative toxicity of glucose and lidocaine administered intrathecally in the rat. Reg Anesth Pain Med. 1998 Sep-Oct; 23(5):444-50. PMID: 9773695.
      View in: PubMed
    18. Freedman JM, Li DK, Drasner K, Jaskela MC, Larsen B, Wi S. Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients. Anesthesiology. 1998 Sep; 89(3):633-41. PMID: 9743399.
      View in: PubMed
    19. Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther. 1998 May; 285(2):413-21. PMID: 9580578.
      View in: PubMed
    20. Chan VW, Garcia J, Al-Kaisy A, Drasner K. A comparative study of low-dose hyperbaric spinal lidocaine 0.5% versus 5% for continuous spinal anesthesia. Reg Anesth Pain Med. 1998 Mar-Apr; 23(2):164-9. PMID: 9570605.
      View in: PubMed
    21. Hampl KF, Heinzmann-Wiedmer S, Luginbuehl I, Harms C, Seeberger M, Schneider MC, Drasner K. Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. Anesthesiology. 1998 Mar; 88(3):629-33. PMID: 9523805.
      View in: PubMed
    22. Sakura S, Sumi M, Sakaguchi Y, Saito Y, Kosaka Y, Drasner K. The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine. Anesthesiology. 1997 Oct; 87(4):771-8. PMID: 9357877.
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    23. Drasner K. Lidocaine spinal anesthesia: a vanishing therapeutic index? Anesthesiology. 1997 Sep; 87(3):469-72. PMID: 9316947.
      View in: PubMed
    24. Sakura S, Hashimoto K, Bollen AW, Ciriales R, Drasner K. Intrathecal catheterization in the rat. Improved technique for morphologic analysis of drug-induced injury. Anesthesiology. 1996 Nov; 85(5):1184-9. PMID: 8916837.
      View in: PubMed
    25. Hampl KF, Schneider MC, Pargger H, Gut J, Drewe J, Drasner K. A similar incidence of transient neurologic symptoms after spinal anesthesia with 2% and 5% lidocaine. Anesth Analg. 1996 Nov; 83(5):1051-4. PMID: 8895284.
      View in: PubMed
    26. Weitz SR, Drasner K. Spontaneous intracranial hypotension: a series. Anesthesiology. 1996 Oct; 85(4):923-5. PMID: 8873565.
      View in: PubMed
    27. Sakura S, Drasner K. [Neurologic sequelae of spinal anesthesia: local anesthetic toxicity]. Masui. 1996 Jul; 45(7):846-51. PMID: 8741475.
      View in: PubMed
    28. Sakura S, Bollen AW, Ciriales R, Drasner K. Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesth Analg. 1995 Aug; 81(2):338-46. PMID: 7618726.
      View in: PubMed
    29. Weitz SR, Drasner K. Local anesthetic test dose as a predictor of effective epidural opioid analgesia. Anesthesiology. 1995 Jul; 83(1):96-100. PMID: 7605025.
      View in: PubMed
    30. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33. PMID: 7879930.
      View in: PubMed
    31. Sakura S, Chan VW, Ciriales R, Drasner K. The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat. Anesthesiology. 1995 Jan; 82(1):236-40. PMID: 7832306.
      View in: PubMed
    32. Drasner K, Sakura S, Chan VW, Bollen AW, Ciriales R. Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat. Anesthesiology. 1994 Apr; 80(4):847-52. PMID: 8024139.
      View in: PubMed
    33. Drasner K. Models for local anesthetic toxicity from continuous spinal anesthesia. Reg Anesth. 1993 Nov-Dec; 18(6 Suppl):434-8. PMID: 8110644.
      View in: PubMed
    34. Drasner K, Rigler ML, Sessler DI, Stoller ML. Cauda equina syndrome following intended epidural anesthesia. Anesthesiology. 1992 Sep; 77(3):582-5. PMID: 1519794.
      View in: PubMed
    35. Rigler ML, Drasner K. Distribution of catheter-injected local anesthetic in a model of the subarachnoid space. Anesthesiology. 1991 Oct; 75(4):684-92. PMID: 1928779.
      View in: PubMed
    36. Miller AC, Scherba-Krugliak L, Toy PT, Drasner K. Hypotension during transfusion of autologous blood. Anesthesiology. 1991 Mar; 74(3):624-8. PMID: 2001042.
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    37. Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, Bohner D. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg. 1991 Mar; 72(3):275-81. PMID: 1994754.
      View in: PubMed
    38. Fassoulaki A, Drasner K, Eger EI. Is chronic ethanol consumption associated with tolerance to intrathecal lidocaine in the rat? Anesth Analg. 1990 May; 70(5):489-92. PMID: 2331064.
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    39. O'Connor ME, Drasner K. Preoperative laboratory testing of children undergoing elective surgery. Anesth Analg. 1990 Feb; 70(2):176-80. PMID: 2301750.
      View in: PubMed
    40. Drasner K, Bernards CM, Ozanne GM. Intrathecal morphine reduces the minimum alveolar concentration of halothane in humans. Anesthesiology. 1988 Sep; 69(3):310-2. PMID: 2843066.
      View in: PubMed
    41. Drasner K, Fields HL. Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat. Pain. 1988 Mar; 32(3):309-12. PMID: 3362566.
      View in: PubMed
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