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Kenneth Drasner, MD

Title(s)Professor Emeritus, Anesthesia
SchoolSchool of Medicine
Address1001 Potrero Ave, SFGH 5
San Francisco CA 94110
Phone628-206-8163
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    LOCAL ANESTHETIC NEUROTOXICITY
    NIH/NIGMS R01GM051887Apr 1, 1996 - Mar 31, 2001
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion. Anesthesiology. 2012 Feb; 116(2):334-9. Ruan W, French D, Wong A, Drasner K, Wu AH. PMID: 22273855.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    2. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila). 2011 Nov; 49(9):801-9. French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH. PMID: 21981684.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansPHPublic Health
    3. Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose. Clin Toxicol (Phila). 2011 Apr; 49(4):340-4. French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH. PMID: 21563913.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    4. Anesthetic effects on the developing nervous system: if you aren't concerned, you haven't been paying attention. Anesthesiology. 2010 Jul; 113(1):10-2. Drasner K. PMID: 20508495.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    5. Safety of ultrasound-guided regional anesthesia. Anesthesiology. 2010 Jun; 112(6):1538-9. Gray AT, Drasner K. PMID: 20502123.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):140-4. Hiller DB, Di Gregorio G, Kelly K, Ripper R, Edelman L, Boumendjel R, Drasner K, Weinberg GL. PMID: 20301820.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    7. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):152-61. Neal JM, Bernards CM, Butterworth JF, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL. PMID: 20216033.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimals
    8. Local anesthetic systemic toxicity: a historical perspective. Reg Anesth Pain Med. 2010 Mar-Apr; 35(2):162-6. Drasner K. PMID: 20216034.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    9. Continuous spinal analgesia for labor and delivery: a born-again technique? Anesthesiology. 2008 Feb; 108(2):184-6. Drasner K, Smiley R. PMID: 18212561.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Chloroprocaine spinal anesthesia: back to the future? Anesth Analg. 2005 Feb; 100(2):549-52. Drasner K. PMID: 15673892.
      View in: PubMed   Mentions:    Fields:    
    11. Thoracic epidural anesthesia: asleep at the wheal? Anesth Analg. 2004 Aug; 99(2):578-9. Drasner K. PMID: 15271742.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Sodium bisulfite: scapegoat for chloroprocaine neurotoxicity? Anesthesiology. 2004 Jan; 100(1):85-91. Taniguchi M, Bollen AW, Drasner K. PMID: 14695728.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    13. Comparative spinal neurotoxicity of prilocaine and lidocaine. Anesthesiology. 2002 Nov; 97(5):1250-3. Kishimoto T, Bollen AW, Drasner K. PMID: 12411812.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    14. Local anesthetic neurotoxicity: clinical injury and strategies that may minimize risk. Reg Anesth Pain Med. 2002 Nov-Dec; 27(6):576-80. Drasner K. PMID: 12430107.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat. Anesthesiology. 2001 May; 94(5):876-81. Hashimoto K, Hampl KF, Nakamura Y, Bollen AW, Feiner J, Drasner K. PMID: 11388541.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Low concentrations of halothane increase response to a noxious thermal stimulus and attenuate the antinociceptive effect of intraventricular but not intrathecal morphine. Anesthesiology. 2001 Feb; 94(2):298-302. Drasner K. PMID: 11176095.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Comparative toxicity of glucose and lidocaine administered intrathecally in the rat. Reg Anesth Pain Med. 1998 Sep-Oct; 23(5):444-50. Hashimoto K, Sakura S, Bollen AW, Ciriales R, Drasner K. PMID: 9773695.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    18. Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients. Anesthesiology. 1998 Sep; 89(3):633-41. Freedman JM, Li DK, Drasner K, Jaskela MC, Larsen B, Wi S. PMID: 9743399.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    19. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther. 1998 May; 285(2):413-21. Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD. PMID: 9580578.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    20. Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. Anesthesiology. 1998 Mar; 88(3):629-33. Hampl KF, Heinzmann-Wiedmer S, Luginbuehl I, Harms C, Seeberger M, Schneider MC, Drasner K. PMID: 9523805.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    21. A comparative study of low-dose hyperbaric spinal lidocaine 0.5% versus 5% for continuous spinal anesthesia. Reg Anesth Pain Med. 1998 Mar-Apr; 23(2):164-9. Chan VW, Garcia J, Al-Kaisy A, Drasner K. PMID: 9570605.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    22. The addition of phenylephrine contributes to the development of transient neurologic symptoms after spinal anesthesia with 0.5% tetracaine. Anesthesiology. 1997 Oct; 87(4):771-8. Sakura S, Sumi M, Sakaguchi Y, Saito Y, Kosaka Y, Drasner K. PMID: 9357877.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Lidocaine spinal anesthesia: a vanishing therapeutic index? Anesthesiology. 1997 Sep; 87(3):469-72. Drasner K. PMID: 9316947.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Intrathecal catheterization in the rat. Improved technique for morphologic analysis of drug-induced injury. Anesthesiology. 1996 Nov; 85(5):1184-9. Sakura S, Hashimoto K, Bollen AW, Ciriales R, Drasner K. PMID: 8916837.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    25. A similar incidence of transient neurologic symptoms after spinal anesthesia with 2% and 5% lidocaine. Anesth Analg. 1996 Nov; 83(5):1051-4. Hampl KF, Schneider MC, Pargger H, Gut J, Drewe J, Drasner K. PMID: 8895284.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    26. Spontaneous intracranial hypotension: a series. Anesthesiology. 1996 Oct; 85(4):923-5. Weitz SR, Drasner K. PMID: 8873565.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. [Neurologic sequelae of spinal anesthesia: local anesthetic toxicity]. Masui. 1996 Jul; 45(7):846-51. Sakura S, Drasner K. PMID: 8741475.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    28. Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesth Analg. 1995 Aug; 81(2):338-46. Sakura S, Bollen AW, Ciriales R, Drasner K. PMID: 7618726.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. Local anesthetic test dose as a predictor of effective epidural opioid analgesia. Anesthesiology. 1995 Jul; 83(1):96-100. Weitz SR, Drasner K. PMID: 7605025.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. PMID: 7879930.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    31. The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat. Anesthesiology. 1995 Jan; 82(1):236-40. Sakura S, Chan VW, Ciriales R, Drasner K. PMID: 7832306.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    32. Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat. Anesthesiology. 1994 Apr; 80(4):847-52. Drasner K, Sakura S, Chan VW, Bollen AW, Ciriales R. PMID: 8024139.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    33. Models for local anesthetic toxicity from continuous spinal anesthesia. Reg Anesth. 1993 Nov-Dec; 18(6 Suppl):434-8. Drasner K. PMID: 8110644.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    34. Cauda equina syndrome following intended epidural anesthesia. Anesthesiology. 1992 Sep; 77(3):582-5. Drasner K, Rigler ML, Sessler DI, Stoller ML. PMID: 1519794.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    35. Distribution of catheter-injected local anesthetic in a model of the subarachnoid space. Anesthesiology. 1991 Oct; 75(4):684-92. Rigler ML, Drasner K. PMID: 1928779.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    36. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg. 1991 Mar; 72(3):275-81. Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, Bohner D. PMID: 1994754.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    37. Hypotension during transfusion of autologous blood. Anesthesiology. 1991 Mar; 74(3):624-8. Miller AC, Scherba-Krugliak L, Toy PT, Drasner K. PMID: 2001042.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Is chronic ethanol consumption associated with tolerance to intrathecal lidocaine in the rat? Anesth Analg. 1990 May; 70(5):489-92. Fassoulaki A, Drasner K, Eger EI. PMID: 2331064.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    39. Preoperative laboratory testing of children undergoing elective surgery. Anesth Analg. 1990 Feb; 70(2):176-80. O'Connor ME, Drasner K. PMID: 2301750.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    40. Intrathecal morphine reduces the minimum alveolar concentration of halothane in humans. Anesthesiology. 1988 Sep; 69(3):310-2. Drasner K, Bernards CM, Ozanne GM. PMID: 2843066.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    41. Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat. Pain. 1988 Mar; 32(3):309-12. Drasner K, Fields HL. PMID: 3362566.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
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