Pekka Talke, MD

Title(s)Professor Emeritus, Anesthesia
SchoolSchool of Medicine
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ORCID ORCID Icon0000-0003-4839-2376 Additional info
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    Collapse Biography 
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    UT Medical Branch at GalvestonMD1985Medicine
    UT Medical Branch at GalvestonResidency1989Anesthesiology

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    Dr. Pekka Talke is an anesthesiologist with more than 30 years of experience. He cared for patients in the operating rooms with a particular focus on neuroanesthesia (optimizing anesthesia during neurological surgeries). He served as chief of neuroanesthesia for 15 years.

    For more than three decades, Talke has conducted research that focuses on noninvasive physiological monitoring (using devices outside the body to continuously assess a patient's status) and blood vessel function.

    Talke earned his medical degree at the University of Texas Medical Branch at Galveston, where he also completed a residency in anesthesiology. He is a member of the Society for Neuroscience in Anesthesiology and Critical Care, and has served on its board of directors.

    Talke is a native of Finland.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effect of the Location of Tetanic Stimulation on Autonomic Responses: A Randomized Cross-Over Pilot Study. J Pain Res. 2024; 17:209-217. Talke P, Talke I. PMID: 38223663; PMCID: PMC10787570.
      View in: PubMed   Mentions:
    2. Bilateral Superficial Trigeminal Nerve Blocks are not More Effective than a Placebo in Abolishing Post-operative Headache Pain in Pituitary Transsphenoidal Neurosurgery: A Prospective, Randomized, Doubleblinded Clinical Trial. Rev Recent Clin Trials. 2023; 18(3):228-237. Srejic U, Litonius E, Gandhi S, Talke P, Maties O, Siegmueller C, Magsaysay A, Hasen D, Kunwar S, Seth R, Gibson L, Bickler P. PMID: 36843368; PMCID: PMC10514508.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    3. Electroencephalographic Arousal Patterns Under Dexmedetomidine Sedation. Anesth Analg. 2018 10; 127(4):951-959. Sleigh JW, Vacas S, Flexman AM, Talke PO. PMID: 29933272.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    4. Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers. Br J Clin Pharmacol. 2018 06; 84(6):1364-1372. Talke P, Anderson BJ. PMID: 29495085; PMCID: PMC5980451.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    5. The Effect of Tracheal Intubation-Induced Autonomic Response on Photoplethysmography. Anesthesiol Res Pract. 2017; 2017:7646541. Talke P. PMID: 28469670; PMCID: PMC5392400.
      View in: PubMed   Mentions: 1  
    6. Republished: Society for Neuroscience in Anesthesiology and Critical Care expert consensus statement: Anesthetic management of endovascular treatment for acute ischemic stroke. Stroke. 2014 Aug; 45(8):e138-50. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD. PMID: 25070964.
      View in: PubMed   Mentions: 21     Fields:    
    7. Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: a pharmacokinetic and pharmacodynamic study. Anesthesiology. 2014 May; 120(5):1118-25. Flexman AM, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO. PMID: 24487703.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    8. Society for Neuroscience in Anesthesiology and Critical Care Expert consensus statement: anesthetic management of endovascular treatment for acute ischemic stroke*: endorsed by the Society of NeuroInterventional Surgery and the Neurocritical Care Society. J Neurosurg Anesthesiol. 2014 Apr; 26(2):95-108. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD. PMID: 24594652.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    9. The time when hypotension occurs may be important in the management of intraarterial thrombolysis for stroke. Anesthesiology. 2012 Sep; 117(3):683-4; author reply 684. Gelb AW, Talke PO. PMID: 22914722.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Hemodynamic stability after intraarterial injection of verapamil for cerebral vasospasm. Anesth Analg. 2012 Jun; 114(6):1292-6. Flexman AM, Ryerson CJ, Talke PO. PMID: 22451596.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers. Br J Anaesth. 2012 May; 108(5):838-44. Hamunen K, Kontinen V, Hakala E, Talke P, Paloheimo M, Kalso E. PMID: 22369767.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    12. The effects of sympathectomy on finger photoplethysmography and temperature measurements in healthy subjects. Anesth Analg. 2011 Jul; 113(1):78-83. Talke P, Snapir A, Huiku M. PMID: 21519049.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Photoplethysmographic waveform: what do the numbers mean? Acta Anaesthesiol Scand. 2010 Aug; 54(7):900; author reply 900. Talke P. PMID: 20649517.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy. J Neurosurg. 2010 Mar; 112(3):479-90. Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS. PMID: 19681683; PMCID: PMC2866526.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    15. Recent advances in pulse oximetry. F1000 Med Rep. 2009 Aug 26; 1. Cannesson M, Talke P. PMID: 20948714; PMCID: PMC2948314.
      View in: PubMed   Mentions: 6  
    16. It's hot to be cool. Anesthesiology. 2009 Jul; 111(1):10-1. Talke PO. PMID: 19512865.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. Br J Anaesth. 2009 Jan; 102(1):38-46. Snapir A, Talke P, Posti J, Huiku M, Kentala E, Scheinin M. PMID: 18987056.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Expecting the unexpected. Anesth Analg. 2008 Jun; 106(6):1605-6. Talke PO, Maze M. PMID: 18499586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. J Neurosurg Anesthesiol. 2007 Jul; 19(3):195-9. Talke P, Stapelfeldt C, Garcia P. PMID: 17592352.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    20. Effect of peripheral vasoconstriction on pulse oximetry. J Clin Monit Comput. 2006 Oct; 20(5):305-9. Talke P, Stapelfeldt C. PMID: 16841243.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    21. Positive end-expiratory pressure ventilation increases extravascular lung water due to a decrease in lung lymph flow. Anaesth Intensive Care. 2006 Jun; 34(3):329-33. Maybauer DM, Talke PO, Westphal M, Maybauer MO, Traber LD, Enkhbaatar P, Morita N, Traber DL. PMID: 16802485.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    22. Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging. Magn Reson Med. 2005 Nov; 54(5):1107-14. Martin AJ, Larson PS, Ostrem JL, Keith Sootsman W, Talke P, Weber OM, Levesque N, Myers J, Starr PA. PMID: 16206144.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    23. Intraoperative clonidine administration to neurosurgical patients. Anesth Analg. 2005 Sep; 101(3):923. Talke PO, Lobo EP, Stapelfeldt C, Brown R. PMID: 16116018.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction. Pharmacogenet Genomics. 2005 May; 15(5):357-63. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A. PMID: 15864138.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    25. Postcraniotomy pain remains a real headache! Eur J Anaesthesiol. 2005 May; 22(5):325-7. Talke PO, Gelb AW. PMID: 15918377.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    26. Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers. Anesthesiology. 2005 Mar; 102(3):536-42. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A. PMID: 15731590.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    27. Intraoperative clonidine administration to neurosurgical patients. Anesth Analg. 2005 Jan; 100(1):226-232. Stapelfeldt C, Lobo EP, Brown R, Talke PO. PMID: 15616082.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    28. Intracranial vascular surgery. Curr Opin Anaesthesiol. 2004 Oct; 17(5):357-61. Talke P. PMID: 17023890.
      View in: PubMed   Mentions:    Fields:    
    29. Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Anesthesiology. 2003 Jul; 99(1):65-70. Talke P, Lobo E, Brown R. PMID: 12826844.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCTClinical Trials
    30. Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. Acta Anaesthesiol Scand. 2003 Mar; 47(3):347-54. Talke P, Xu M, Paloheimo M, Kalso E. PMID: 12648203.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    31. Autonomic nervous system responses during sedative infusions of dexmedetomidine. Anesthesiology. 2002 Sep; 97(3):592-8. Hogue CW, Talke P, Stein PK, Richardson C, Domitrovich PP, Sessler DI. PMID: 12218525.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCellsCTClinical Trials
    32. A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery. Anesth Analg. 2002 Aug; 95(2):430-5, table of contents. Talke P, Caldwell JE, Brown R, Dodson B, Howley J, Richardson CA. PMID: 12145066.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    33. Clonidine-induced vasoconstriction in awake volunteers. Anesth Analg. 2001 Aug; 93(2):271-6, 1st contents page. Talke PO, Lobo EP, Brown R, Richardson CA. PMID: 11473842.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    34. Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout. J Auton Pharmacol. 2001 Jun; 21(3):159-64. Gao DW, Talke PO, Dae MW. PMID: 11844024.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    35. Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. Br J Clin Pharmacol. 2001 Jan; 51(1):27-33. Larson MD, Talke PO. PMID: 11167662; PMCID: PMC2014430.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    36. The effects of clonidine on human digital vasculature. Anesth Analg. 2000 Oct; 91(4):793-7. Talke PO, Caldwell JE, Richardson CA, Heier T. PMID: 11004028.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    37. The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep. Anesth Analg. 2000 May; 90(5):1060-6. Talke PO, Traber DL, Richardson CA, Harper DD, Traber LD. PMID: 10781453.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    38. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg. 2000 Apr; 90(4):834-9. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A. PMID: 10735784.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCTClinical Trials
    39. Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology. 1999 Jul; 91(1):127-30. Talke P, Caldwell JE, Richardson CA. PMID: 10422937.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    40. Amount of air infused to patient increases as fluid flow rates decrease when using the Hotline HL-90 fluid warmer. J Clin Monit Comput. 1999 May; 15(3-4):149-52. Woon S, Talke P. PMID: 12568165.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. The effects of dexmedetomidine on neuromuscular blockade in human volunteers. Anesth Analg. 1999 Mar; 88(3):633-9. Talke PO, Caldwell JE, Richardson CA, Kirkegaard-Nielsen H, Stafford M. PMID: 10072019.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    42. Concept for easy fiberoptic intubation via a laryngeal airway mask. Anesth Analg. 1999 Jan; 88(1):228-9. Talke PO, Nguyen H. PMID: 9895100.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Receptor-specific reversible sedation: beginning of new era of anesthesia? Anesthesiology. 1998 Sep; 89(3):560-1. Talke P. PMID: 9743390.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg. 1997 Nov; 85(5):1136-42. Talke P, Richardson CA, Scheinin M, Fisher DM. PMID: 9356115.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCTClinical Trials
    45. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Anesthesiology. 1997 Oct; 87(4):835-41. Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C. PMID: 9357885.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCTClinical Trials
    46. The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers. Anesthesiology. 1997 Sep; 87(3):553-8. Lee HW, Caldwell JE, Dodson B, Talke P, Howley J. PMID: 9316960.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    47. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesth Analg. 1997 Aug; 85(2):358-64. Talke P, Tong C, Lee HW, Caldwell J, Eisenach JC, Richardson CA. PMID: 9249114.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    48. Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology. 1996 Nov; 85(5):999-1004. Talke P, Caldwell J, Dodsont B, Richardson CA. PMID: 8916815.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    49. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology. 1996 Sep; 85(3):551-7. Talke P, Bickler PE. PMID: 8853085.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    50. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. PMID: 7879930.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    51. Dose-response study of oral famotidine for reduction of gastric acidity and volume in outpatients and inpatients. Anesth Analg. 1993 Dec; 77(6):1143-8. Talke PO, Solanki DR. PMID: 8250305.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    52. Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Anesthesiology. 1993 Jan; 78(1):15-20. Scuderi P, Wetchler B, Sung YF, Mingus M, DuPen S, Claybon L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S, et al. PMID: 8424548.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    53. Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol Suppl. 1992 Nov; 6:55-62. Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L, Leslie J, Talke P, Apfelbaum J, Sharifi-Azad S, et al. PMID: 1425626.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    54. Measurement of systolic blood pressure using pulse oximetry during helicopter flight. Crit Care Med. 1991 Jul; 19(7):934-7. Talke PO. PMID: 2055082.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    55. Monitoring patients during helicopter flight. J Clin Monit. 1990 Apr; 6(2):139-40. Talke P, Nichols RJ, Traber DL. PMID: 2352001.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    56. Effects of allopurinol on smoke inhalation in the ovine model. J Appl Physiol (1985). 1990 Jan; 68(1):228-34. Ahn SY, Sugi K, Talke P, Theissen JL, Linares HA, Traber LD, Herndon DN, Traber DL. PMID: 2312462.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    57. Does measurement of systolic blood pressure with a pulse oximeter correlate with conventional methods? J Clin Monit. 1990 Jan; 6(1):5-9. Talke P, Nichols RJ, Traber DL. PMID: 2295896.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    58. A model of ovine endotoxemia characterized by an increased cardiac output. Circ Shock. 1985; 17(2):103-8. Talke P, Dunn A, Lawlis L, Sziebert L, White A, Herndon D, Flynn JT, Traber D. PMID: 3902275.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    59. Transcutaneous PO2 measurements in health and peripheral arterial occlusive disease. Surgery. 1982 Feb; 91(2):156-63. Franzeck UK, Talke P, Bernstein EF, Golbranson FL, Fronek A. PMID: 7058493.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
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