Pekka Talke, MD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address500 Parnassus Avenue
San Francisco CA 94117
Phone415-476-8963
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Electroencephalographic Arousal Patterns Under Dexmedetomidine Sedation. Anesth Analg. 2018 10; 127(4):951-959. Sleigh JW, Vacas S, Flexman AM, Talke PO. PMID: 29933272.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    2. Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers. Br J Clin Pharmacol. 2018 06; 84(6):1364-1372. Talke P, Anderson BJ. PMID: 29495085.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    3. The Effect of Tracheal Intubation-Induced Autonomic Response on Photoplethysmography. Anesthesiol Res Pract. 2017; 2017:7646541. Talke P. PMID: 28469670.
      View in: PubMed   Mentions:
    4. Republished: Society for Neuroscience in Anesthesiology and Critical Care expert consensus statement: Anesthetic management of endovascular treatment for acute ischemic stroke. Stroke. 2014 Aug; 45(8):e138-50. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD. PMID: 25070964.
      View in: PubMed   Mentions: 17     Fields:    
    5. Enzyme-inducing anticonvulsants increase plasma clearance of dexmedetomidine: a pharmacokinetic and pharmacodynamic study. Anesthesiology. 2014 May; 120(5):1118-25. Flexman AM, Wong H, Riggs KW, Shih T, Garcia PA, Vacas S, Talke PO. PMID: 24487703.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    6. Society for Neuroscience in Anesthesiology and Critical Care Expert consensus statement: anesthetic management of endovascular treatment for acute ischemic stroke*: endorsed by the Society of NeuroInterventional Surgery and the Neurocritical Care Society. J Neurosurg Anesthesiol. 2014 Apr; 26(2):95-108. Talke PO, Sharma D, Heyer EJ, Bergese SD, Blackham KA, Stevens RD. PMID: 24594652.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    7. The time when hypotension occurs may be important in the management of intraarterial thrombolysis for stroke. Anesthesiology. 2012 Sep; 117(3):683-4; author reply 684. Gelb AW, Talke PO. PMID: 22914722.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Hemodynamic stability after intraarterial injection of verapamil for cerebral vasospasm. Anesth Analg. 2012 Jun; 114(6):1292-6. Flexman AM, Ryerson CJ, Talke PO. PMID: 22451596.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers. Br J Anaesth. 2012 May; 108(5):838-44. Hamunen K, Kontinen V, Hakala E, Talke P, Paloheimo M, Kalso E. PMID: 22369767.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    10. The effects of sympathectomy on finger photoplethysmography and temperature measurements in healthy subjects. Anesth Analg. 2011 Jul; 113(1):78-83. Talke P, Snapir A, Huiku M. PMID: 21519049.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy. J Neurosurg. 2010 Mar; 112(3):479-90. Starr PA, Martin AJ, Ostrem JL, Talke P, Levesque N, Larson PS. PMID: 19681683.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    12. Recent advances in pulse oximetry. F1000 Med Rep. 2009 Aug 26; 1. Cannesson M, Talke P. PMID: 20948714.
      View in: PubMed   Mentions:
    13. It's hot to be cool. Anesthesiology. 2009 Jul; 111(1):10-1. Talke PO. PMID: 19512865.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. Br J Anaesth. 2009 Jan; 102(1):38-46. Snapir A, Talke P, Posti J, Huiku M, Kentala E, Scheinin M. PMID: 18987056.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Expecting the unexpected. Anesth Analg. 2008 Jun; 106(6):1605-6. Talke PO, Maze M. PMID: 18499586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Dexmedetomidine does not reduce epileptiform discharges in adults with epilepsy. J Neurosurg Anesthesiol. 2007 Jul; 19(3):195-9. Talke P, Stapelfeldt C, Garcia P. PMID: 17592352.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    17. Effect of peripheral vasoconstriction on pulse oximetry. J Clin Monit Comput. 2006 Oct; 20(5):305-9. Talke P, Stapelfeldt C. PMID: 16841243.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging. Magn Reson Med. 2005 Nov; 54(5):1107-14. Martin AJ, Larson PS, Ostrem JL, Keith Sootsman W, Talke P, Weber OM, Levesque N, Myers J, Starr PA. PMID: 16206144.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    19. Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction. Pharmacogenet Genomics. 2005 May; 15(5):357-63. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A. PMID: 15864138.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Postcraniotomy pain remains a real headache! Eur J Anaesthesiol. 2005 May; 22(5):325-7. Talke PO, Gelb AW. PMID: 15918377.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    21. Effect of alpha2B-adrenoceptor polymorphism on peripheral vasoconstriction in healthy volunteers. Anesthesiology. 2005 Mar; 102(3):536-42. Talke P, Stapelfeldt C, Lobo E, Brown R, Scheinin M, Snapir A. PMID: 15731590.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Intraoperative clonidine administration to neurosurgical patients. Anesth Analg. 2005 Jan; 100(1):226-32. Stapelfeldt C, Lobo EP, Brown R, Talke PO. PMID: 15616082.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    23. Intracranial vascular surgery. Curr Opin Anaesthesiol. 2004 Oct; 17(5):357-61. Talke P. PMID: 17023890.
      View in: PubMed   Mentions:    Fields:    
    24. Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Anesthesiology. 2003 Jul; 99(1):65-70. Talke P, Lobo E, Brown R. PMID: 12826844.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCTClinical Trials
    25. Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats. Acta Anaesthesiol Scand. 2003 Mar; 47(3):347-54. Talke P, Xu M, Paloheimo M, Kalso E. PMID: 12648203.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    26. Autonomic nervous system responses during sedative infusions of dexmedetomidine. Anesthesiology. 2002 Sep; 97(3):592-8. Hogue CW, Talke P, Stein PK, Richardson C, Domitrovich PP, Sessler DI. PMID: 12218525.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    27. A comparison of three anesthetic techniques in patients undergoing craniotomy for supratentorial intracranial surgery. Anesth Analg. 2002 Aug; 95(2):430-5, table of contents. Talke P, Caldwell JE, Brown R, Dodson B, Howley J, Richardson CA. PMID: 12145066.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    28. Clonidine-induced vasoconstriction in awake volunteers. Anesth Analg. 2001 Aug; 93(2):271-6, 1st contents page. Talke PO, Lobo EP, Brown R, Richardson CA. PMID: 11473842.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    29. Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout. J Auton Pharmacol. 2001 Jun; 21(3):159-64. Gao DW, Talke PO, Dae MW. PMID: 11844024.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    30. Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. Br J Clin Pharmacol. 2001 Jan; 51(1):27-33. Larson MD, Talke PO. PMID: 11167662.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    31. The effects of clonidine on human digital vasculature. Anesth Analg. 2000 Oct; 91(4):793-7. Talke PO, Caldwell JE, Richardson CA, Heier T. PMID: 11004028.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    32. The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep. Anesth Analg. 2000 May; 90(5):1060-6. Talke PO, Traber DL, Richardson CA, Harper DD, Traber LD. PMID: 10781453.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    33. The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery. Anesth Analg. 2000 Apr; 90(4):834-9. Talke P, Chen R, Thomas B, Aggarwall A, Gottlieb A, Thorborg P, Heard S, Cheung A, Son SL, Kallio A. PMID: 10735784.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCTClinical Trials
    34. Sevoflurane increases lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology. 1999 Jul; 91(1):127-30. Talke P, Caldwell JE, Richardson CA. PMID: 10422937.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    35. The effects of dexmedetomidine on neuromuscular blockade in human volunteers. Anesth Analg. 1999 Mar; 88(3):633-9. Talke PO, Caldwell JE, Richardson CA, Kirkegaard-Nielsen H, Stafford M. PMID: 10072019.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    36. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg. 1997 Nov; 85(5):1136-42. Talke P, Richardson CA, Scheinin M, Fisher DM. PMID: 9356115.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCTClinical Trials
    37. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Anesthesiology. 1997 Oct; 87(4):835-41. Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C. PMID: 9357885.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCTClinical Trials
    38. The effect of clonidine on cerebral blood flow velocity, carbon dioxide cerebral vasoreactivity, and response to increased arterial pressure in human volunteers. Anesthesiology. 1997 Sep; 87(3):553-8. Lee HW, Caldwell JE, Dodson B, Talke P, Howley J. PMID: 9316960.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesth Analg. 1997 Aug; 85(2):358-64. Talke P, Tong C, Lee HW, Caldwell J, Eisenach JC, Richardson CA. PMID: 9249114.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    40. Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology. 1996 Nov; 85(5):999-1004. Talke P, Caldwell J, Dodsont B, Richardson CA. PMID: 8916815.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    41. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology. 1996 Sep; 85(3):551-7. Talke P, Bickler PE. PMID: 8853085.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    42. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. The Study of Perioperative Ischemia Research Group. Anesthesiology. 1995 Mar; 82(3):620-33. Talke P, Li J, Jain U, Leung J, Drasner K, Hollenberg M, Mangano DT. PMID: 7879930.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
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