Khaled Moussawi, MD, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
PronounsHe/Him/His
ORCID ORCID Icon0000-0001-6378-0428 Additional info
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    Collapse Biography 
    Collapse Education and Training
    National Institute on Drug Abuse (NIH/NIDA), Baltimore, MDResearch Fellowship11/2020Substance use disorders
    Johns Hopkins Medicine, Baltimore, MDClinical Fellowship6/2017Neuropsychiatry
    Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, MAResidency06/2016Neurology
    Massachusetts General Hospital, Boston, MAInternship06/2013Internal Medicine
    Medical University of South Carolina, Charleston, SCMD, PhD05/2012Medicine, Neuroscience

    Collapse Overview 
    Collapse Overview
    The Translational Neuropsychiatry Through Neuromodulaton (TN²) laboratory investigates the neurobiology of substance use disorders and uses neuromodulation tools such as Low-Intensity Focused Ultrasound (LIFU), Transcranial Magnetic Stimulation (TMS), and Deep Brain Stimulation (DBS) to treat drug and alcohol addiction and related neuropsychiatric disorders. The goal of the lab is to identify neural biomarkers of craving and drug-seeking behaviors and leverage those findings to develop individualized clinical treatments with neuromodulation.

    Collapse Research 
    Collapse Research Activities and Funding
    Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorder
    NIH UG3DA060431Jun 15, 2024 - May 31, 2026
    Role: Co-Investigator
    Limbic Pallidum DBS for the treatment of severe alcohol use disorder
    NIH UG3AA030505Sep 20, 2022 - Aug 31, 2024
    Role: Co-Investigator
    TMS effects on circuit plasticity and drug seeking in mice.
    NIH R00DA048085Feb 1, 2021 - Jan 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Generalized cue reactivity in rat dopamine neurons after opioids. Nat Commun. 2025 Jan 02; 16(1):321. Lehmann CM, Miller NE, Nair VS, Costa KM, Schoenbaum G, Moussawi K. PMID: 39747036; PMCID: PMC11697388.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Associations of Mild Behavioral Impairment Domains with Brain Volumes in Older Adults. J Acad Consult Liaison Psychiatry. 2024 Nov 25. Young L, Richey LN, Law CA, Esagoff AI, Ismail Z, Senjem ML, Jack CR, Shrestha S, Gottesman RF, Moussawi K, Peters ME, Schneider ALC. PMID: 39603508.
      View in: PubMed   Mentions:    Fields:    
    3. Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions. Brain Sci. 2024 Oct 30; 14(11). Keihani A, Sanguineti C, Chaichian O, Huston CA, Moore C, Cheng C, Janssen SA, Donati FL, Mayeli A, Moussawi K, Phillips ML, Ferrarelli F. PMID: 39595858; PMCID: PMC11592166.
      View in: PubMed   Mentions:
    4. Cost-Effectiveness Analysis of Deep Brain Stimulation for the Treatment of Alcohol Use Disorder and Alcoholic Liver Disease. medRxiv. 2024 Aug 23. Abiola OA, Lehmann C, Moussawi K, Jalal H. PMID: 39228721; PMCID: PMC11370503.
      View in: PubMed   Mentions:
    5. Generalized cue reactivity in dopamine neurons after opioids. bioRxiv. 2024 Jun 02. Lehmann CM, Miller NE, Nair VS, Costa KM, Schoenbaum G, Moussawi K. PMID: 38853878; PMCID: PMC11160774.
      View in: PubMed   Mentions:
    6. Opioid modulation of prefrontal cortex cells and circuits. Neuropharmacology. 2024 May 01; 248:109891. Cole RH, Moussawi K, Joffe ME. PMID: 38417545; PMCID: PMC10939756.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Stable, neuron-specific gene expression in the mouse brain. J Biol Eng. 2024 Jan 16; 18(1):8. Ahmed O, Ekumi KM, Nardi FV, Maisumu G, Moussawi K, Lazartigues ED, Liang B, Yakoub AM. PMID: 38229168; PMCID: PMC10790494.
      View in: PubMed   Mentions:
    8. Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment. Am J Psychiatry. 2024 Feb 01; 181(2):100-114. Soleimani G, Joutsa J, Moussawi K, Siddiqi SH, Kuplicki R, Bikson M, Paulus MP, Fox MD, Hanlon CA, Ekhtiari H. PMID: 38018143; PMCID: PMC11318367.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Cell type and sex specific insights into ventral striatum deep brain stimulation for cocaine relapse. Neuropsychopharmacology. 2023 02; 48(3):434-435. Lehmann CM, Moussawi K. PMID: 36513870; PMCID: PMC9852299.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Brain lesions disrupting addiction map to a common human brain circuit. Nat Med. 2022 06; 28(6):1249-1255. Joutsa J, Moussawi K, Siddiqi SH, Abdolahi A, Drew W, Cohen AL, Ross TJ, Deshpande HU, Wang HZ, Bruss J, Stein EA, Volkow ND, Grafman JH, van Wijngaarden E, Boes AD, Fox MD. PMID: 35697842; PMCID: PMC9205767.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    11. Deep brain stimulation effect on anterior pallidum reduces motor impulsivity in Parkinson's disease. Brain Stimul. 2022 Jan-Feb; 15(1):23-31. Moussawi K, Kim MJ, Baybayan S, Wood M, Mills KA. PMID: 34749005; PMCID: PMC8816820.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Operant Vapor Self-administration in Mice. Bio Protoc. 2021 May 20; 11(10):e4023. Marchette RCN, Tunstall BJ, Vendruscolo LF, Moussawi K. PMID: 34150930; PMCID: PMC8187126.
      View in: PubMed   Mentions: 3  
    13. Excitation of medium spiny neurons by 'inhibitory' ultrapotent chemogenetics via shifts in chloride reversal potential. Elife. 2021 04 06; 10. Gantz SC, Ortiz MM, Belilos AJ, Moussawi K. PMID: 33822716; PMCID: PMC8024007.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    14. A 33-Year-Old Man with Progressive Diffuse and Focal Neuropsychiatric Signs without Localizing Correlates on Brain Imaging: A Systematic Approach to Diagnosis. J Psychiatry Psychiatr Disord. 2020; 4(5):307-314. Moussawi K, Gholipour T, Rao V. PMID: 35265793; PMCID: PMC8903194.
      View in: PubMed   Mentions:
    15. Fentanyl vapor self-administration model in mice to study opioid addiction. Sci Adv. 2020 08; 6(32):eabc0413. Moussawi K, Ortiz MM, Gantz SC, Tunstall BJ, Marchette RCN, Bonci A, Koob GF, Vendruscolo LF. PMID: 32821843; PMCID: PMC7406365.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    16. Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. Elife. 2020 04 01; 9. Gantz SC, Moussawi K, Hake HS. PMID: 32234214; PMCID: PMC7180053.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    17. Paraneoplastic PRES from lymphoma induced hypercalcemia: Case report and review of the literature. eNeurologicalSci. 2018 Dec; 13:24-25. Moussawi K, Meltzer EI, Levin SN, Prasad S. PMID: 30456318; PMCID: PMC6231055.
      View in: PubMed   Mentions: 4  
    18. Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine. Curr Opin Neurobiol. 2019 02; 54:66-72. Francis TC, Gantz SC, Moussawi K, Bonci A. PMID: 30237117; PMCID: PMC10131346.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Report of transient events in a cocaine-dependent volunteer who received iTBS. Brain Stimul. 2018 May - Jun; 11(3):631-633. Steele VR, Maxwell AM, Ross TJ, Moussawi K, Abulseoud OO, Stein EA, Salmeron BJ. PMID: 29429954.
      View in: PubMed   Mentions: 2     Fields:    
    20. Teaching Clinical Reasoning with an Example Mnemonic for the Neuropsychiatric Syndromes of Traumatic Brain Injury. Acad Psychiatry. 2018 Oct; 42(5):686-689. Peters ME, Moussawi K, Rao V. PMID: 29022277; PMCID: PMC5895537.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Intracranial Tuberculoma in a Patient With Untreated Human Immunodeficiency Virus. JAMA Neurol. 2017 03 01; 74(3):356-357. Meltzer E, Moussawi K. PMID: 28135346.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Clinical Reasoning: A 20-year-old man with headache and double vision. Neurology. 2016 10 11; 87(15):e162-e167. Moussawi K, Gupta A, Reda H. PMID: 27765826; PMCID: PMC5573089.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Abstinence From Drug Dependence After Bilateral Globus Pallidus Hypoxic-Ischemic Injury. Biol Psychiatry. 2016 11 01; 80(9):e79-e80. Moussawi K, Kalivas PW, Lee JW. PMID: 27311800; PMCID: PMC5238511.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. Brainstem and limbic encephalitis with paraneoplastic neuromyelitis optica. J Clin Neurosci. 2016 Jan; 23:159-161. Moussawi K, Lin DJ, Matiello M, Chew S, Morganstern D, Vaitkevicius H. PMID: 26412254.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Optogenetic inhibition of cocaine seeking in rats. Addict Biol. 2013 Jan; 18(1):50-3. Stefanik MT, Moussawi K, Kupchik YM, Smith KC, Miller RL, Huff ML, Deisseroth K, Kalivas PW, LaLumiere RT. PMID: 22823160; PMCID: PMC3578202.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCellsPHPublic Health
    26. Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addict Biol. 2013 Jan; 18(1):40-9. Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW. PMID: 22340009; PMCID: PMC3360124.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    27. The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biol Psychiatry. 2012 Jun 01; 71(11):978-86. Kupchik YM, Moussawi K, Tang XC, Wang X, Kalivas BC, Kolokithas R, Ogburn KB, Kalivas PW. PMID: 22137594; PMCID: PMC3340445.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    28. Extracellular glutamate: functional compartments operate in different concentration ranges. Front Syst Neurosci. 2011; 5:94. Moussawi K, Riegel A, Nair S, Kalivas PW. PMID: 22275885; PMCID: PMC3254064.
      View in: PubMed   Mentions: 85  
    29. Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19407-12. Shen H, Moussawi K, Zhou W, Toda S, Kalivas PW. PMID: 22084102; PMCID: PMC3228456.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    30. Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. J Pharmacol Exp Ther. 2011 May; 337(2):487-93. Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE. PMID: 21303920; PMCID: PMC3083102.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    31. Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):385-90. Moussawi K, Zhou W, Shen H, Reichel CM, See RE, Carr DB, Kalivas PW. PMID: 21173236; PMCID: PMC3017187.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCellsPHPublic Health
    32. Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking. J Neurosci. 2010 Jun 09; 30(23):7984-92. Knackstedt LA, Moussawi K, Lalumiere R, Schwendt M, Klugmann M, Kalivas PW. PMID: 20534846; PMCID: PMC2893028.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    33. Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. Eur J Pharmacol. 2010 Aug 10; 639(1-3):115-22. Moussawi K, Kalivas PW. PMID: 20371233; PMCID: PMC4351804.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    34. Altered dendritic spine plasticity in cocaine-withdrawn rats. J Neurosci. 2009 Mar 04; 29(9):2876-84. Shen HW, Toda S, Moussawi K, Bouknight A, Zahm DS, Kalivas PW. PMID: 19261883; PMCID: PMC2698814.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    35. N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci. 2009 Feb; 12(2):182-9. Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. PMID: 19136971; PMCID: PMC2661026.
      View in: PubMed   Mentions: 243     Fields:    Translation:AnimalsPHPublic Health
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