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Andrew Krystal, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPsychiatry
Address401 Parnassus Ave.
San Francisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear
    NIH/NIMH R21MH106772Apr 15, 2015 - Jan 31, 2018
    Role: Principal Investigator
    Instrument to Co-register EEG and NIRS for Accurate Sleep Sorting
    NIH/NINDS R21NS085818Sep 22, 2014 - Aug 31, 2016
    Role: Co-Principal Investigator
    2/3-Reducing Suicide Ideation Through Insomnia Treatment (REST-IT)
    NIH/NIMH R01MH095780Aug 3, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Nocturnal Deterusor Overactivity In Overactive Bladder Syndrome
    NIH/NIDDK R01DK087717Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Biomarkers of the Response to CBT for Insomnia in Major Depression
    NIH/NHLBI R01HL096492Oct 1, 2009 - Jul 31, 2014
    Role: Principal Investigator
    3/3-Improving Depression Outcome by Adding CBT for Insomnia to Antidepressants
    NIH/NIMH R01MH079256Jun 1, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Behavioral Insomnia Treatment in Chronic Fatigue Syndrome
    NIH/NINR R21NR010539Jul 20, 2007 - May 31, 2009
    Role: Principal Investigator
    OPTIMIZING ECT STIMULUS DOSING USING THE ICTAL EEG
    NIH/NIMH R29MH057532May 1, 1998 - Feb 28, 2004
    Role: Principal Investigator
    IMPROVING ECT EFFECTIVENESS THROUGH ICTAL EEG ANALYSIS
    NIH/NIMH K20MH001151Apr 1, 1994 - Mar 31, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dominguez JE, Habib AS, Krystal A. A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease. Sleep Med Rev. 2018 May 28. PMID: 29929840.
      View in: PubMed
    2. Dominguez JE, Krystal A, Habib AS. Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management. Anesth Analg. 2018 Apr 11. PMID: 29649034.
      View in: PubMed
    3. Bei B, Asarnow LD, Krystal A, Edinger JD, Buysse DJ, Manber R. Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories. J Consult Clin Psychol. 2018 Mar; 86(3):282-293. PMID: 29504795.
      View in: PubMed
    4. McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson S, Morales O, Nelson BG, George MS, Lisanby SH. Dr McClintock and Colleagues Reply. J Clin Psychiatry. 2018 Jan/Feb; 79(1). PMID: 29505182.
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    5. McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH. Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression. J Clin Psychiatry. 2018 Jan/Feb; 79(1). PMID: 28541649.
      View in: PubMed
    6. Rumble ME, Dickson D, McCall WV, Krystal A, Case D, Rosenquist PB, Benca RM. The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review. J Affect Disord. 2018 Feb; 227:721-730. PMID: 29179142.
      View in: PubMed
    7. Connor KM, Ceesay P, Hutzelmann J, Snavely D, Krystal A, Trivedi MH, Thase M, Lines C, Herring WJ, Michelson D. Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. Int J Neuropsychopharmacol. 2017 Aug 01; 20(8):613-618. PMID: 28582570.
      View in: PubMed
    8. Goucher Miranda H, Krystal A, Fierro MA. Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation? Anesthesiology. 2017 08; 127(2):397-398. PMID: 28719531.
      View in: PubMed
    9. Sateia MJ, Buysse DJ, Krystal A, Neubauer DN. Adverse Effects of Hypnotic Medications. J Clin Sleep Med. 2017 Jun 15; 13(6):839. PMID: 28454603.
      View in: PubMed
    10. Evans JL, Nadler JW, Preud'homme XA, Fang E, Daughtry RL, Chapman JB, Attarian D, Wellman S, Krystal A. Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium. Clin Neurophysiol. 2017 08; 128(8):1421-1425. PMID: 28618293.
      View in: PubMed
    11. Carney CE, Edinger JD, Kuchibhatla M, Lachowski AM, Bogouslavsky O, Krystal A, Shapiro CM. Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial. Sleep. 2017 04 01; 40(4). PMID: 28199710.
      View in: PubMed
    12. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal A, Walsh JK, Lines C, Roth T, Michelson D. Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials. Am J Geriatr Psychiatry. 2017 Jul; 25(7):791-802. PMID: 28427826.
      View in: PubMed
    13. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal A, Walsh JK, Lines C, Roth T, Michelson D. Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data. Psychopharmacology (Berl). 2017 Jun; 234(11):1703-1711. PMID: 28265715.
      View in: PubMed
    14. Edinger JD, Manber R, Buysse DJ, Krystal A, Thase ME, Gehrman P, Fairholme CP, Luther J, Wisniewski S. Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study. J Clin Sleep Med. 2017 Feb 15; 13(2):205-213. PMID: 27784414.
      View in: PubMed
    15. Sateia MJ, Buysse DJ, Krystal A, Neubauer DN, Heald JL. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017 Feb 15; 13(2):307-349. PMID: 27998379.
      View in: PubMed
    16. Samson DR, Manus MB, Krystal A, Fakir E, Yu JJ, Nunn CL. Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar. Am J Hum Biol. 2017 Jul 08; 29(4). PMID: 28181718.
      View in: PubMed
    17. Krystal A, Prather AA. Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi. JAMA Psychiatry. 2017 Jan 01; 74(1):15-16. PMID: 27902827.
      View in: PubMed
    18. Krystal A, Preud'homme XA. Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia. Sleep. 2017 01 01; 40(1). PMID: 28364461.
      View in: PubMed
    19. Bathgate CJ, Edinger JD, Krystal A. Insomnia Patients With Objective Short Sleep Duration Have a Blunted Response to Cognitive Behavioral Therapy for Insomnia. Sleep. 2017 01 01; 40(1). PMID: 28364452.
      View in: PubMed
    20. Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV. National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 Feb; 3(1):6-19. PMID: 28346153.
      View in: PubMed
    21. Ptáoek LJ, Fu YH, Krystal A. Sleep and Mood: Chicken or Egg? Biol Psychiatry. 2016 12 01; 80(11):810-811. PMID: 27968724.
      View in: PubMed
    22. Lunsford-Avery JR, Krystal A, Kollins SH. Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research. Clin Psychol Rev. 2016 Oct 23; 50:159-174. PMID: 27969004.
      View in: PubMed
    23. Manber R, Buysse DJ, Edinger J, Krystal A, Luther JF, Wisniewski SR, Trockel M, Kraemer HC, Thase ME. Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial. J Clin Psychiatry. 2016 Oct; 77(10):e1316-e1323. PMID: 27788313.
      View in: PubMed
    24. Carlezon WA, Krystal A. Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. Depress Anxiety. 2016 10; 33(10):895-906. PMID: 27699938.
      View in: PubMed
    25. Jacobsen JPR, Krystal A, Krishnan KRR, Caron MG. Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale. Trends Pharmacol Sci. 2016 11; 37(11):933-944. PMID: 27692695.
      View in: PubMed
    26. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal A, Walsh JK, Lines C, Roth T, Michelson D. Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials. J Clin Sleep Med. 2016 Sep 15; 12(9):1215-25. PMID: 27397664; PMCID: PMC4990943 [Available on 03/15/17].
      View in: PubMed, PubMed Central
    27. McCall WV, Benca RM, Rosenquist PB, Riley MA, McCloud L, Newman JC, Case D, Rumble M, Krystal A. Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA. Am J Psychiatry. 2017 Jan 01; 174(1):18-25. PMID: 27609243.
      View in: PubMed
    28. Krystal A, Mittoux A, Meisels P, Baker RA. Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study. Prim Care Companion CNS Disord. 2016 Sep 08; 18(5). PMID: 27835722.
      View in: PubMed
    29. Blanco MB, Dausmann KH, Faherty SL, Klopfer P, Krystal A, Schopler R, Yoder AD. Hibernation in a primate: does sleep occur? R Soc Open Sci. 2016 Aug; 3(8):160282. PMID: 27853604.
      View in: PubMed
    30. Nunn CL, Samson DR, Krystal A. Shining evolutionary light on human sleep and sleep disorders. Evol Med Public Health. 2016; 2016(1):227-43. PMID: 27470330; PMCID: PMC4972941.
      View in: PubMed, PubMed Central
    31. Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal A, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 07 15; 80(2):84-86. PMID: 27346079.
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    32. Bathgate CJ, Edinger JD, Wyatt JK, Krystal A. Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia. Sleep. 2016 05 01; 39(5):1037-45. PMID: 26951399; PMCID: PMC4835301 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    33. Krystal A, Zammit G. The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia. Hum Psychopharmacol. 2016 05; 31(3):206-16. PMID: 27108672.
      View in: PubMed
    34. Krystal A, Sorscher AJ. Recognizing and managing insomnia in primary care and specialty settings. J Clin Psychiatry. 2016 Apr; 77(4):e471. PMID: 27137433.
      View in: PubMed
    35. Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal A. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504. J Clin Psychiatry. 2016 Apr; 77(4):483-91. PMID: 26890894.
      View in: PubMed
    36. Morin CM, Edinger JD, Krystal A, Buysse DJ, Beaulieu-Bonneau S, Ivers H. Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial. Trials. 2016 Mar 03; 17(1):118. PMID: 26940892; PMCID: PMC4778294.
      View in: PubMed, PubMed Central
    37. Krystal A. New Developments in Insomnia Medications of Relevance to Mental Health Disorders. Psychiatr Clin North Am. 2015 Dec; 38(4):843-60. PMID: 26600112.
      View in: PubMed
    38. Morin CM, Drake CL, Harvey AG, Krystal A, Manber R, Riemann D, Spiegelhalder K. Insomnia disorder. Nat Rev Dis Primers. 2015 09 03; 1:15026. PMID: 27189779.
      View in: PubMed
    39. Krystal A. Current, emerging, and newly available insomnia medications. J Clin Psychiatry. 2015 Aug; 76(8):e1045. PMID: 26335094.
      View in: PubMed
    40. Krystal JH, Stossel S, Krystal A. Restricting Benzodiazepines to Short-Term Prescription. JAMA Psychiatry. 2015 Jul; 72(7):734-5. PMID: 25923129.
      View in: PubMed
    41. Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal A, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O'Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS. Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression. Brain Stimul. 2015 Jul-Aug; 8(4):787-94. PMID: 26143022.
      View in: PubMed
    42. Peterchev AV, Krystal A, Rosa MA, Lisanby SH. Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy. Neuropsychopharmacology. 2015 Aug; 40(9):2076-84. PMID: 25920013; PMCID: PMC4613599.
      View in: PubMed, PubMed Central
    43. Ivgy-May N, Ruwe F, Krystal A, Roth T. Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial. Sleep Med. 2015 Jul; 16(7):838-44. PMID: 26047892.
      View in: PubMed
    44. McCall WV, Benca RM, Rosenquist PB, Riley MA, Hodges C, Gubosh B, McCloud L, Newman JC, Case D, Rumble M, Mayo M, White KH, Phillips M, Krystal A. A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety. Clin Trials. 2015 Jun; 12(3):189-98. PMID: 25733676; PMCID: PMC4424155.
      View in: PubMed, PubMed Central
    45. Rapp PE, Keyser DO, Albano A, Hernandez R, Gibson DB, Zambon RA, Hairston WD, Hughes JD, Krystal A, Nichols AS. Traumatic brain injury detection using electrophysiological methods. Front Hum Neurosci. 2015; 9:11. PMID: 25698950; PMCID: PMC4316720.
      View in: PubMed, PubMed Central
    46. Tek C, Palmese LB, Krystal A, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial. Schizophr Res. 2014 Dec; 160(1-3):180-5. PMID: 25454802.
      View in: PubMed
    47. Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal A, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D. Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials. Biol Psychiatry. 2016 Jan 15; 79(2):136-48. PMID: 25526970.
      View in: PubMed
    48. Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal A, Laughren T, Macfadden W, Marin R, Nierenberg AA, Tohen M. Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord. 2014 Oct; 168:439-51. PMID: 25113957.
      View in: PubMed
    49. McClintock SM, Choi J, Deng ZD, Appelbaum LG, Krystal A, Lisanby SH. Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. J ECT. 2014 Jun; 30(2):165-76. PMID: 24820942; PMCID: PMC4143898.
      View in: PubMed, PubMed Central
    50. Goforth HW, Preud'homme XA, Krystal A. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain. Sleep. 2014 Jun 01; 37(6):1053-60. PMID: 24882900; PMCID: PMC4015379.
      View in: PubMed, PubMed Central
    51. Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal A, Benca RM, Cohn M, Lines C, Roth T, Herring WJ. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 May; 13(5):461-71. PMID: 24680372.
      View in: PubMed
    52. Greve DN, Duntley SP, Larson-Prior L, Krystal A, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. PMID: 24532997; PMCID: PMC3899316.
      View in: PubMed, PubMed Central
    53. Low Y, Goforth H, Preud'homme X, Edinger J, Krystal A. Insomnia in HIV-infected patients: pathophysiologic implications. AIDS Rev. 2014 Jan-Mar; 16(1):3-13. PMID: 24522778.
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    54. Krystal A, Zhang W, Davidson JR, Connor KM. The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks. J Psychopharmacol. 2014 May; 28(5):457-65. PMID: 24288237.
      View in: PubMed
    55. Wang X, Bey AL, Chung L, Krystal A, Jiang YH. Therapeutic approaches for shankopathies. Dev Neurobiol. 2014 Feb; 74(2):123-35. PMID: 23536326.
      View in: PubMed
    56. Krystal A, Schopler B, Kobbe S, Williams C, Rakatondrainibe H, Yoder AD, Klopfer P. The relationship of sleep with temperature and metabolic rate in a hibernating primate. PLoS One. 2013; 8(9):e69914. PMID: 24023713; PMCID: PMC3762832.
      View in: PubMed, PubMed Central
    57. Minkel J, Krystal A. Optimizing the Pharmacologic Treatment of Insomnia: Current Status and Future Horizons. Sleep Med Clin. 2013 Sep 01; 8(3):333-350. PMID: 24015116.
      View in: PubMed
    58. Edinger JD, Means MK, Krystal A. Does physiological hyperarousal enhance error rates among insomnia sufferers? Sleep. 2013 Aug 01; 36(8):1179-86. PMID: 23904678; PMCID: PMC3700715.
      View in: PubMed, PubMed Central
    59. Mirrakhimov AE, Brewbaker CL, Krystal A, Kwatra MM. Obstructive sleep apnea and delirium: exploring possible mechanisms. Sleep Breath. 2014 Mar; 18(1):19-29. PMID: 23584846.
      View in: PubMed
    60. Roth T, Krystal A, Steinberg FJ, Singh NN, Moline M. Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study. Sleep. 2013 Feb 01; 36(2):189-96. PMID: 23372266; PMCID: PMC3543068.
      View in: PubMed, PubMed Central
    61. Krystal A, Richelson E, Roth T. Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev. 2013 Aug; 17(4):263-72. PMID: 23357028.
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    62. Krystal A, Benca RM, Kilduff TS. Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. J Clin Psychiatry. 2013; 74 Suppl 1:3-20. PMID: 24107804.
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    63. Krystal A. Psychiatric disorders and sleep. Neurol Clin. 2012 Nov; 30(4):1389-413. PMID: 23099143; PMCID: PMC3493205.
      View in: PubMed, PubMed Central
    64. Rosenquist PB, Krystal A, Heart KL, Demitrack MA, McCall WV. Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder. Psychiatry Res. 2013 Jan 30; 205(1-2):67-73. PMID: 23021320.
      View in: PubMed
    65. Preud'homme XA, Amundsen CL, Webster GD, Krystal A. Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls. Int Urogynecol J. 2013 Mar; 24(3):501-8. PMID: 22855113.
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    66. Krystal A, Roth T, Simon RD. Shift work disorder case studies: applying management principles in clinical practice. J Clin Psychiatry. 2012 Aug; 73(8):e25. PMID: 22967784.
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    67. Krystal A, McCall WV, Fava M, Joffe H, Soares CN, Huang H, Grinell T, Zummo J, Spalding W, Marshall R. Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity. Prim Care Companion CNS Disord. 2012; 14(4). PMID: 23251857; PMCID: PMC3505126.
      View in: PubMed, PubMed Central
    68. Low Y, Goforth HW, Omonuwa T, Preud'homme X, Edinger J, Krystal A. Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients. Clin Neurophysiol. 2012 Dec; 123(12):2402-5. PMID: 22727712.
      View in: PubMed
    69. Krystal A, Sutherland J, Hochman DW. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012; 7(4):e35417. PMID: 22514741; PMCID: PMC3325958.
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    70. Flink BJ, Rivelli SK, Cox EA, White WD, Falcone G, Vail TP, Young CC, Bolognesi MP, Krystal A, Trzepacz PT, Moon RE, Kwatra MM. Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly. Anesthesiology. 2012 Apr; 116(4):788-96. PMID: 22337162; PMCID: PMC3321273.
      View in: PubMed, PubMed Central
    71. Krystal A, Huang H, Zummo J, Grinnell T, Marshall RD. A WASO sub-group analysis of a 6-month study of eszopiclone 3 mg. Sleep Med. 2012 Jun; 13(6):691-6. PMID: 22465450.
      View in: PubMed
    72. Carney CE, Buysse DJ, Ancoli-Israel S, Edinger JD, Krystal A, Lichstein KL, Morin CM. The consensus sleep diary: standardizing prospective sleep self-monitoring. Sleep. 2012 Feb 01; 35(2):287-302. PMID: 22294820; PMCID: PMC3250369.
      View in: PubMed, PubMed Central
    73. Krystal A. How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder. J Clin Psychiatry. 2012 Feb; 73(2):e05. PMID: 22401482.
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    74. Palmese LB, DeGeorge PC, Ratliff JC, Srihari VH, Wexler BE, Krystal A, Tek C. Insomnia is frequent in schizophrenia and associated with night eating and obesity. Schizophr Res. 2011 Dec; 133(1-3):238-43. PMID: 21856129.
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    75. Low Y, Preud'homme X, Goforth HW, Omonuwa T, Krystal A. The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study. Sleep. 2011 Dec 01; 34(12):1723-6. PMID: 22131611; PMCID: PMC3208851.
      View in: PubMed, PubMed Central
    76. Krystal A, Lankford A, Durrence HH, Ludington E, Jochelson P, Rogowski R, Roth T. Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. Sleep. 2011 Oct 01; 34(10):1433-42. PMID: 21966075; PMCID: PMC3174845.
      View in: PubMed, PubMed Central
    77. Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud'homme X, Krystal A. Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes. Biol Psychiatry. 2011 Oct 15; 70(8):794-9. PMID: 21762878.
      View in: PubMed
    78. Edinger JD, Wyatt JK, Stepanski EJ, Olsen MK, Stechuchak KM, Carney CE, Chiang A, Crisostomo MI, Lineberger MD, Means MK, Radtke RA, Wohlgemuth WK, Krystal A. Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis. Arch Gen Psychiatry. 2011 Oct; 68(10):992-1002. PMID: 21646568.
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    79. Carney CE, Moss TG, Harris AL, Edinger JD, Krystal A. Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients? J Psychiatr Res. 2011 Sep; 45(9):1243-9. PMID: 21482427; PMCID: PMC3157494.
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    80. Richey SM, Krystal A. Pharmacological advances in the treatment of insomnia. Curr Pharm Des. 2011; 17(15):1471-5. PMID: 21476952.
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    81. Krystal A. Antidepressant and Antipsychotic Drugs. Sleep Med Clin. 2010 Dec 01; 5(4):571-589. PMID: 21499530.
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    82. Krystal A, Durrence HH, Scharf M, Jochelson P, Rogowski R, Ludington E, Roth T. Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. Sleep. 2010 Nov; 33(11):1553-61. PMID: 21102997; PMCID: PMC2954705.
      View in: PubMed, PubMed Central
    83. Flynn KE, Shelby RA, Mitchell SA, Fawzy MR, Hardy NC, Husain AM, Keefe FJ, Krystal A, Porter LS, Reeve BB, Weinfurt KP. Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)). Psychooncology. 2010 Oct; 19(10):1086-93. PMID: 20013938; PMCID: PMC2888823.
      View in: PubMed, PubMed Central
    84. Krystal A, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A. The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia. J Clin Sleep Med. 2010 Aug 15; 6(4):315-21. PMID: 20726278; PMCID: PMC2919660.
      View in: PubMed, PubMed Central
    85. McCall WV, Blocker JN, D'Agostino R, Kimball J, Boggs N, Lasater B, Haskett R, Krystal A, McDonald WM, Rosenquist PB. Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression. J Clin Sleep Med. 2010 Aug 15; 6(4):322-9. PMID: 20726279; PMCID: PMC2919661.
      View in: PubMed, PubMed Central
    86. Janicak PG, Nahas Z, Lisanby SH, Solvason HB, Sampson SM, McDonald WM, Marangell LB, Rosenquist P, McCall WV, Kimball J, O'Reardon JP, Loo C, Husain MH, Krystal A, Gilmer W, Dowd SM, Demitrack MA, Schatzberg AF. Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study. Brain Stimul. 2010 Oct; 3(4):187-99. PMID: 20965447.
      View in: PubMed
    87. Krystal A. In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications. Sleep. 2010 Jul; 33(7):859-60. PMID: 20614842; PMCID: PMC2894424.
      View in: PubMed, PubMed Central
    88. Krystal A, Preud'homme XA, Amundsen CL, Webster GD. Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study. J Urol. 2010 Aug; 184(2):623-8. PMID: 20639027.
      View in: PubMed
    89. Krystal A, Edinger JD. Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia. Sleep. 2010 May; 33(5):669-77. PMID: 20469809; PMCID: PMC2864882.
      View in: PubMed, PubMed Central
    90. Ancoli-Israel S, Krystal A, McCall WV, Schaefer K, Wilson A, Claus R, Rubens R, Roth T. A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia. Sleep. 2010 Feb; 33(2):225-34. PMID: 20175406; PMCID: PMC2817909.
      View in: PubMed, PubMed Central
    91. Ohayon MM, Krystal A, Roehrs TA, Roth T, Vitiello MV. Using difficulty resuming sleep to define nocturnal awakenings. Sleep Med. 2010 Mar; 11(3):236-41. PMID: 20075004; PMCID: PMC2830306.
      View in: PubMed, PubMed Central
    92. Krystal A, Harsh JR, Yang R, Yang RR, Rippon GA, Lankford DA. A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression. J Clin Psychiatry. 2010 Jan; 71(1):32-40. PMID: 20051221.
      View in: PubMed
    93. Krystal A. The treatment of primary insomnia. CNS Spectr. 2009 Dec; 14(12 Suppl 13):6-10. PMID: 20448512.
      View in: PubMed
    94. Omonuwa TS, Goforth HW, Preud'homme X, Krystal A. The pharmacologic management of insomnia in patients with HIV. J Clin Sleep Med. 2009 Jun 15; 5(3):251-62. PMID: 19960648; PMCID: PMC2699172.
      View in: PubMed, PubMed Central
    95. Krystal A. A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice. Sleep Med Rev. 2009 Aug; 13(4):265-74. PMID: 19153052.
      View in: PubMed
    96. Preud'homme XA, Lanquart JP, Krystal A, Bogaerts P, Linkowski P. Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep? Clin Neurophysiol. 2008 Dec; 119(12):2753-61. PMID: 18986831.
      View in: PubMed
    97. Carney CE, Ulmer C, Edinger JD, Krystal A, Knauss F. Assessing depression symptoms in those with insomnia: an examination of the beck depression inventory second edition (BDI-II). J Psychiatr Res. 2009 Feb; 43(5):576-82. PMID: 18954876; PMCID: PMC2677199.
      View in: PubMed, PubMed Central
    98. Krystal A, Edinger JD. Measuring sleep quality. Sleep Med. 2008 Sep; 9 Suppl 1:S10-7. PMID: 18929313.
      View in: PubMed
    99. Lisanby SH, Husain MM, Rosenquist PB, Maixner D, Gutierrez R, Krystal A, Gilmer W, Marangell LB, Aaronson S, Daskalakis ZJ, Canterbury R, Richelson E, Sackeim HA, George MS. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology. 2009 Jan; 34(2):522-34. PMID: 18704101.
      View in: PubMed
    100. Edinger JD, Means MK, Carney CE, Krystal A. Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia. Sleep. 2008 May; 31(5):599-607. PMID: 18517030; PMCID: PMC2398751.
      View in: PubMed, PubMed Central
    101. Krystal A, Goforth HW, Roth T. Effects of antipsychotic medications on sleep in schizophrenia. Int Clin Psychopharmacol. 2008 May; 23(3):150-60. PMID: 18408529.
      View in: PubMed
    102. Pollack M, Kinrys G, Krystal A, McCall WV, Roth T, Schaefer K, Rubens R, Roach J, Huang H, Krishnan R. Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Arch Gen Psychiatry. 2008 May; 65(5):551-62. PMID: 18458207.
      View in: PubMed
    103. Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal A, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15; 63(8):725-7. PMID: 18371494.
      View in: PubMed
    104. Chiang A, Krystal A. Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent. J Clin Sleep Med. 2008 Apr 15; 4(2):155-6. PMID: 18468314; PMCID: PMC2335395.
      View in: PubMed, PubMed Central
    105. Krystal A, Erman M, Zammit GK, Soubrane C, Roth T. Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study. Sleep. 2008 Jan; 31(1):79-90. PMID: 18220081; PMCID: PMC2225552.
      View in: PubMed, PubMed Central
    106. Krystal A, Thakur M, Roth T. Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia. Ann Clin Psychiatry. 2008 Jan-Mar; 20(1):39-46. PMID: 18297585.
      View in: PubMed
    107. Brummett BH, Krystal A, Ashley-Koch A, Kuhn CM, Züchner S, Siegler IC, Barefoot JC, Ballard EL, Gwyther LP, Williams RB. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med. 2007 Sep-Oct; 69(7):621-4. PMID: 17766685.
      View in: PubMed
    108. Walsh JK, Krystal A, Amato DA, Rubens R, Caron J, Wessel TC, Schaefer K, Roach J, Wallenstein G, Roth T. Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations. Sleep. 2007 Aug; 30(8):959-68. PMID: 17702264; PMCID: PMC1978384.
      View in: PubMed, PubMed Central
    109. Roth T, Krystal A, Lieberman JA. Long-term issues in the treatment of sleep disorders. CNS Spectr. 2007 Jul; 12(7 Suppl 10):1-14. PMID: 17603408.
      View in: PubMed
    110. Brummett BH, Krystal A, Siegler IC, Kuhn C, Surwit RS, Züchner S, Ashley-Koch A, Barefoot JC, Williams RB. Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med. 2007 Jun; 69(5):396-401. PMID: 17585061; PMCID: PMC2777888.
      View in: PubMed, PubMed Central
    111. Lim L, Krystal A. Psychotic disorder in a patient with central and extrapontine myelinolysis. Psychiatry Clin Neurosci. 2007 Jun; 61(3):320-2. PMID: 17472602.
      View in: PubMed
    112. Krystal A, Davidson JR. The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 2007 Apr 15; 61(8):925-7. PMID: 17397667.
      View in: PubMed
    113. Krystal A. Treating the health, quality of life, and functional impairments in insomnia. J Clin Sleep Med. 2007 Feb 15; 3(1):63-72. PMID: 17557457.
      View in: PubMed
    114. Krystal A, Fava M, Rubens R, Wessel T, Caron J, Wilson P, Roth T, McCall WV. Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. J Clin Sleep Med. 2007 Feb 15; 3(1):48-55. PMID: 17557453.
      View in: PubMed
    115. Carney CE, Segal ZV, Edinger JD, Krystal A. A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder. J Clin Psychiatry. 2007 Feb; 68(2):254-60. PMID: 17335324.
      View in: PubMed
    116. Krystal A. Sleep and psychiatric disorders: future directions. Psychiatr Clin North Am. 2006 Dec; 29(4):1115-30; abstract xi. PMID: 17118285.
      View in: PubMed
    117. Zammit GK, Corser B, Doghramji K, Fry JM, James S, Krystal A, Mangano RM. Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening. J Clin Sleep Med. 2006 Oct 15; 2(4):417-23. PMID: 17557470.
      View in: PubMed
    118. McCall WV, Erman M, Krystal A, Rosenberg R, Scharf M, Zammit GK, Wessel T. A polysomnography study of eszopiclone in elderly patients with insomnia. Curr Med Res Opin. 2006 Sep; 22(9):1633-42. PMID: 16968566.
      View in: PubMed
    119. Fava M, McCall WV, Krystal A, Wessel T, Rubens R, Caron J, Amato D, Roth T. Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol Psychiatry. 2006 Jun 01; 59(11):1052-60. PMID: 16581036.
      View in: PubMed
    120. Walsh JK, Perlis M, Rosenthal M, Krystal A, Jiang J, Roth T. Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia. J Clin Sleep Med. 2006 Jan 15; 2(1):35-41. PMID: 17557435.
      View in: PubMed
    121. Edinger JD, Wohlgemuth WK, Krystal A, Rice JR. Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial. Arch Intern Med. 2005 Nov 28; 165(21):2527-35. PMID: 16314551.
      View in: PubMed
    122. Roth T, Walsh JK, Krystal A, Wessel T, Roehrs TA. An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Med. 2005 Nov; 6(6):487-95. PMID: 16230048.
      View in: PubMed
    123. Krystal A. The effect of insomnia definitions, terminology, and classifications on clinical practice. J Am Geriatr Soc. 2005 Jul; 53(7 Suppl):S258-63. PMID: 15982374.
      View in: PubMed
    124. Wohlgemuth WK, Krystal A. Hypnotics should be considered for the initial treatment of chronic insomnia. Pro. J Clin Sleep Med. 2005 Apr 15; 1(2):120-4. PMID: 17561623.
      View in: PubMed
    125. Krystal A. The possibility of preventing functional impairment due to sleep loss by pharmacologically enhancing sleep. Sleep. 2005 Jan; 28(1):16-7. PMID: 15700715.
      View in: PubMed
    126. Perlis ML, McCall WV, Krystal A, Walsh JK. Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia. J Clin Psychiatry. 2004 Aug; 65(8):1128-37. PMID: 15323600.
      View in: PubMed
    127. Singh J, Zarate CA, Krystal A. Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine. Psychopharmacology (Berl). 2004 Apr; 173(1-2):227-8. PMID: 14722708.
      View in: PubMed
    128. Ancoli-Israel S, Benca RM, Edinger JD, Krystal A, Mendelson W, Moldofsky H, Petrie J, Roth T, Walsh JK, Winkelman J. Panel discussion: changing how we think about insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:44-6. PMID: 15153067.
      View in: PubMed
    129. Krystal A, Roth T. Introduction: Definitions, measurements, and management in insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:5-7. PMID: 15153061.
      View in: PubMed
    130. Krystal A. The changing perspective on chronic insomnia management. J Clin Psychiatry. 2004; 65 Suppl 8:20-5. PMID: 15153064.
      View in: PubMed
    131. Krystal A. Depression and insomnia in women. Clin Cornerstone. 2004; 6 Suppl 1B:S19-28. PMID: 15457812.
      View in: PubMed
    132. Krystal A, Walsh JK, Laska E, Caron J, Amato DA, Wessel TC, Roth T. Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep. 2003 Nov 01; 26(7):793-9. PMID: 14655910.
      View in: PubMed
    133. Edinger JD, Krystal A. Subtyping primary insomnia: is sleep state misperception a distinct clinical entity? Sleep Med Rev. 2003 Jun; 7(3):203-14. PMID: 12927120.
      View in: PubMed
    134. Krystal A, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA, Falcone G, Coffey CE. Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci. 2003; 15(1):27-34. PMID: 12556568.
      View in: PubMed
    135. Krystal A. Insomnia in women. Clin Cornerstone. 2003; 5(3):41-50. PMID: 14626540.
      View in: PubMed
    136. Krystal A, Edinger JD, Wohlgemuth WK, Marsh GR. NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep. 2002 Sep 15; 25(6):630-40. PMID: 12224842.
      View in: PubMed
    137. Krystal A, Weiner RD. Low-Frequency Ictal EEG Activity and ECT Therapeutic Impact. Convuls Ther. 1993; 9(3):220-224. PMID: 11941217.
      View in: PubMed
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