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Andrew Krystal, MD

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Tissue-specific insulin resistance in obstructive sleep apnea: role of hypoxia
    NIH/NIDDK R01DK117953Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear
    NIH/NIMH R21MH106772Apr 15, 2015 - Jan 31, 2018
    Role: Principal Investigator
    Instrument to Co-register EEG and NIRS for Accurate Sleep Sorting
    NIH/NINDS R21NS085818Sep 22, 2014 - Aug 31, 2016
    Role: Co-Principal Investigator
    2/3-Reducing Suicide Ideation Through Insomnia Treatment (REST-IT)
    NIH/NIMH R01MH095780Aug 3, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Nocturnal Deterusor Overactivity In Overactive Bladder Syndrome
    NIH/NIDDK R01DK087717Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Biomarkers of the Response to CBT for Insomnia in Major Depression
    NIH/NHLBI R01HL096492Oct 1, 2009 - Jul 31, 2014
    Role: Principal Investigator
    3/3-Improving Depression Outcome by Adding CBT for Insomnia to Antidepressants
    NIH/NIMH R01MH079256Jun 1, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Behavioral Insomnia Treatment in Chronic Fatigue Syndrome
    NIH/NINR R21NR010539Jul 20, 2007 - May 31, 2009
    Role: Principal Investigator
    OPTIMIZING ECT STIMULUS DOSING USING THE ICTAL EEG
    NIH/NIMH R29MH057532May 1, 1998 - Feb 28, 2004
    Role: Principal Investigator
    IMPROVING ECT EFFECTIVENESS THROUGH ICTAL EEG ANALYSIS
    NIH/NIMH K20MH001151Apr 1, 1994 - Mar 31, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E. Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers. J Alzheimers Dis. 2019 Jan 22. PMID: 30689583.
      View in: PubMed
    2. Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J, Szabo S, Murrough J, Shekhar A, Potter W. The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development. Nat Rev Drug Discov. 2018 Dec 28; 18(1):82-84. PMID: 30591715.
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    3. Scangos KW, Weiner RD, Coffey EC, Krystal AD. An Electrophysiological Biomarker That May Predict Treatment Response to ECT. J ECT. 2018 Dec 07. PMID: 30531398.
      View in: PubMed
    4. Szabo ST, Kandra K, Krystal AD. Effect of ?-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy. Int J Clin Pharmacol Ther. 2018 Dec; 56(12):620-622. PMID: 30178743.
      View in: PubMed
    5. Dominguez JE, Krystal AD, Habib AS. Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management. Anesth Analg. 2018 Nov; 127(5):1167-1177. PMID: 29649034.
      View in: PubMed
    6. Herring WJ, Roth T, Krystal AD, Michelson D. Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications. J Sleep Res. 2018 Oct 18; e12782. PMID: 30338596.
      View in: PubMed
    7. Dominguez JE, Grotegut CA, Cooter M, Krystal AD, Habib AS. Screening extremely obese pregnant women for obstructive sleep apnea. Am J Obstet Gynecol. 2018 Dec; 219(6):613.e1-613.e10. PMID: 30217579.
      View in: PubMed
    8. Ohayon MM, Black J, Krystal AD, Shapiro CM, Swick TJ, Bogan R, Wells CC. Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families. Sleep Med. 2019 Jan; 53:88-93. PMID: 30496948.
      View in: PubMed
    9. Beppler EC, Dieffenderfer J, Songkakul T, Krystal A, Bozkurt A. An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul; 2018:2877-2880. PMID: 30441002.
      View in: PubMed
    10. Dominguez JE, Habib AS, Krystal AD. A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease. Sleep Med Rev. 2018 12; 42:37-46. PMID: 29929840.
      View in: PubMed
    11. Bei B, Asarnow LD, Krystal A, Edinger JD, Buysse DJ, Manber R. Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories. J Consult Clin Psychol. 2018 Mar; 86(3):282-293. PMID: 29504795.
      View in: PubMed
    12. McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson S, Morales O, Nelson BG, George MS, Lisanby SH. Dr McClintock and Colleagues Reply. J Clin Psychiatry. 2018 Jan/Feb; 79(1). PMID: 29505182.
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    13. McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal AD, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH. Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression. J Clin Psychiatry. 2018 Jan/Feb; 79(1). PMID: 28541649.
      View in: PubMed
    14. Rumble ME, Dickson D, McCall WV, Krystal AD, Case D, Rosenquist PB, Benca RM. The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review. J Affect Disord. 2018 02; 227:721-730. PMID: 29179142.
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    15. Connor KM, Ceesay P, Hutzelmann J, Snavely D, Krystal AD, Trivedi MH, Thase M, Lines C, Herring WJ, Michelson D. Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. Int J Neuropsychopharmacol. 2017 08 01; 20(8):613-618. PMID: 28582570.
      View in: PubMed
    16. Goucher Miranda H, Krystal AD, Fierro MA. Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation? Anesthesiology. 2017 08; 127(2):397-398. PMID: 28719531.
      View in: PubMed
    17. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN. Adverse Effects of Hypnotic Medications. J Clin Sleep Med. 2017 Jun 15; 13(6):839. PMID: 28454603.
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    18. Evans JL, Nadler JW, Preud'homme XA, Fang E, Daughtry RL, Chapman JB, Attarian D, Wellman S, Krystal AD. Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium. Clin Neurophysiol. 2017 08; 128(8):1421-1425. PMID: 28618293.
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    19. Carney CE, Edinger JD, Kuchibhatla M, Lachowski AM, Bogouslavsky O, Krystal AD, Shapiro CM. Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial. Sleep. 2017 04 01; 40(4). PMID: 28199710.
      View in: PubMed
    20. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials. Am J Geriatr Psychiatry. 2017 Jul; 25(7):791-802. PMID: 28427826.
      View in: PubMed
    21. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data. Psychopharmacology (Berl). 2017 Jun; 234(11):1703-1711. PMID: 28265715.
      View in: PubMed
    22. Edinger JD, Manber R, Buysse DJ, Krystal AD, Thase ME, Gehrman P, Fairholme CP, Luther J, Wisniewski S. Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study. J Clin Sleep Med. 2017 Feb 15; 13(2):205-213. PMID: 27784414.
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    23. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017 Feb 15; 13(2):307-349. PMID: 27998379.
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    24. Samson DR, Manus MB, Krystal AD, Fakir E, Yu JJ, Nunn CL. Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar. Am J Hum Biol. 2017 Jul 08; 29(4). PMID: 28181718.
      View in: PubMed
    25. Krystal AD, Prather AA. Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi. JAMA Psychiatry. 2017 Jan 01; 74(1):15-16. PMID: 27902827.
      View in: PubMed
    26. Krystal AD, Preud'homme XA. Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia. Sleep. 2017 01 01; 40(1). PMID: 28364461.
      View in: PubMed
    27. Bathgate CJ, Edinger JD, Krystal AD. Insomnia Patients With Objective Short Sleep Duration Have a Blunted Response to Cognitive Behavioral Therapy for Insomnia. Sleep. 2017 01 01; 40(1). PMID: 28364452.
      View in: PubMed
    28. Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV. National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 02; 3(1):6-19. PMID: 28346153.
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    29. Ptáoek LJ, Fu YH, Krystal AD. Sleep and Mood: Chicken or Egg? Biol Psychiatry. 2016 12 01; 80(11):810-811. PMID: 27968724.
      View in: PubMed
    30. Lunsford-Avery JR, Krystal AD, Kollins SH. Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research. Clin Psychol Rev. 2016 Dec; 50:159-174. PMID: 27969004.
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    31. Manber R, Buysse DJ, Edinger J, Krystal A, Luther JF, Wisniewski SR, Trockel M, Kraemer HC, Thase ME. Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial. J Clin Psychiatry. 2016 Oct; 77(10):e1316-e1323. PMID: 27788313.
      View in: PubMed
    32. Carlezon WA, Krystal AD. Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. Depress Anxiety. 2016 10; 33(10):895-906. PMID: 27699938.
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    33. Jacobsen JPR, Krystal AD, Krishnan KRR, Caron MG. Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale. Trends Pharmacol Sci. 2016 11; 37(11):933-944. PMID: 27692695.
      View in: PubMed
    34. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials. J Clin Sleep Med. 2016 09 15; 12(9):1215-25. PMID: 27397664.
      View in: PubMed
    35. McCall WV, Benca RM, Rosenquist PB, Riley MA, McCloud L, Newman JC, Case D, Rumble M, Krystal AD. Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA. Am J Psychiatry. 2017 Jan 01; 174(1):18-25. PMID: 27609243.
      View in: PubMed
    36. Krystal AD, Mittoux A, Meisels P, Baker RA. Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study. Prim Care Companion CNS Disord. 2016 Sep 08; 18(5). PMID: 27835722.
      View in: PubMed
    37. Blanco MB, Dausmann KH, Faherty SL, Klopfer P, Krystal AD, Schopler R, Yoder AD. Hibernation in a primate: does sleep occur? R Soc Open Sci. 2016 Aug; 3(8):160282. PMID: 27853604.
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    38. Nunn CL, Samson DR, Krystal AD. Shining evolutionary light on human sleep and sleep disorders. Evol Med Public Health. 2016; 2016(1):227-43. PMID: 27470330.
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    39. Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 07 15; 80(2):84-86. PMID: 27346079.
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    40. Bathgate CJ, Edinger JD, Wyatt JK, Krystal AD. Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia. Sleep. 2016 05 01; 39(5):1037-45. PMID: 26951399; PMCID: PMC4835301 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    41. Krystal AD, Zammit G. The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia. Hum Psychopharmacol. 2016 05; 31(3):206-16. PMID: 27108672.
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    42. Krystal AD, Sorscher AJ. Recognizing and managing insomnia in primary care and specialty settings. J Clin Psychiatry. 2016 04; 77(4):e471. PMID: 27137433.
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    43. Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504. J Clin Psychiatry. 2016 04; 77(4):483-91. PMID: 26890894.
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    44. Morin CM, Edinger JD, Krystal AD, Buysse DJ, Beaulieu-Bonneau S, Ivers H. Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial. Trials. 2016 Mar 03; 17(1):118. PMID: 26940892; PMCID: PMC4778294.
      View in: PubMed, PubMed Central
    45. Krystal AD. New Developments in Insomnia Medications of Relevance to Mental Health Disorders. Psychiatr Clin North Am. 2015 Dec; 38(4):843-60. PMID: 26600112.
      View in: PubMed
    46. Morin CM, Drake CL, Harvey AG, Krystal AD, Manber R, Riemann D, Spiegelhalder K. Insomnia disorder. Nat Rev Dis Primers. 2015 09 03; 1:15026. PMID: 27189779.
      View in: PubMed
    47. Krystal AD. Current, emerging, and newly available insomnia medications. J Clin Psychiatry. 2015 Aug; 76(8):e1045. PMID: 26335094.
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    48. Krystal JH, Stossel S, Krystal AD. Restricting Benzodiazepines to Short-Term Prescription. JAMA Psychiatry. 2015 Jul; 72(7):734-5. PMID: 25923129.
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    49. Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O'Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS. Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression. Brain Stimul. 2015 Jul-Aug; 8(4):787-94. PMID: 26143022.
      View in: PubMed
    50. Peterchev AV, Krystal AD, Rosa MA, Lisanby SH. Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy. Neuropsychopharmacology. 2015 Aug; 40(9):2076-84. PMID: 25920013; PMCID: PMC4613599.
      View in: PubMed, PubMed Central
    51. Ivgy-May N, Ruwe F, Krystal A, Roth T. Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial. Sleep Med. 2015 Jul; 16(7):838-44. PMID: 26047892.
      View in: PubMed
    52. McCall WV, Benca RM, Rosenquist PB, Riley MA, Hodges C, Gubosh B, McCloud L, Newman JC, Case D, Rumble M, Mayo M, White KH, Phillips M, Krystal AD. A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety. Clin Trials. 2015 Jun; 12(3):189-98. PMID: 25733676; PMCID: PMC4424155.
      View in: PubMed, PubMed Central
    53. Rapp PE, Keyser DO, Albano A, Hernandez R, Gibson DB, Zambon RA, Hairston WD, Hughes JD, Krystal A, Nichols AS. Traumatic brain injury detection using electrophysiological methods. Front Hum Neurosci. 2015; 9:11. PMID: 25698950; PMCID: PMC4316720.
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    54. Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial. Schizophr Res. 2014 Dec; 160(1-3):180-5. PMID: 25454802.
      View in: PubMed
    55. Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D. Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials. Biol Psychiatry. 2016 Jan 15; 79(2):136-48. PMID: 25526970.
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    56. Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, Macfadden W, Marin R, Nierenberg AA, Tohen M. Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord. 2014 Oct; 168:439-51. PMID: 25113957.
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    57. McClintock SM, Choi J, Deng ZD, Appelbaum LG, Krystal AD, Lisanby SH. Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. J ECT. 2014 Jun; 30(2):165-76. PMID: 24820942; PMCID: PMC4143898.
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    58. Goforth HW, Preud'homme XA, Krystal AD. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain. Sleep. 2014 Jun 01; 37(6):1053-60. PMID: 24882900; PMCID: PMC4015379.
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    59. Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 May; 13(5):461-71. PMID: 24680372.
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    60. Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. PMID: 24532997; PMCID: PMC3899316.
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    61. Low Y, Goforth H, Preud'homme X, Edinger J, Krystal A. Insomnia in HIV-infected patients: pathophysiologic implications. AIDS Rev. 2014 Jan-Mar; 16(1):3-13. PMID: 24522778.
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    62. Krystal AD, Zhang W, Davidson JR, Connor KM. The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks. J Psychopharmacol. 2014 May; 28(5):457-65. PMID: 24288237.
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    63. Wang X, Bey AL, Chung L, Krystal AD, Jiang YH. Therapeutic approaches for shankopathies. Dev Neurobiol. 2014 Feb; 74(2):123-35. PMID: 23536326.
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    64. Krystal AD, Schopler B, Kobbe S, Williams C, Rakatondrainibe H, Yoder AD, Klopfer P. The relationship of sleep with temperature and metabolic rate in a hibernating primate. PLoS One. 2013; 8(9):e69914. PMID: 24023713; PMCID: PMC3762832.
      View in: PubMed, PubMed Central
    65. Minkel J, Krystal AD. Optimizing the Pharmacologic Treatment of Insomnia: Current Status and Future Horizons. Sleep Med Clin. 2013 Sep 01; 8(3):333-350. PMID: 24015116.
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    66. Edinger JD, Means MK, Krystal AD. Does physiological hyperarousal enhance error rates among insomnia sufferers? Sleep. 2013 Aug 01; 36(8):1179-86. PMID: 23904678; PMCID: PMC3700715.
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    67. Mirrakhimov AE, Brewbaker CL, Krystal AD, Kwatra MM. Obstructive sleep apnea and delirium: exploring possible mechanisms. Sleep Breath. 2014 Mar; 18(1):19-29. PMID: 23584846.
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    68. Roth T, Krystal A, Steinberg FJ, Singh NN, Moline M. Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study. Sleep. 2013 Feb 01; 36(2):189-96. PMID: 23372266; PMCID: PMC3543068.
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    69. Krystal AD, Richelson E, Roth T. Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev. 2013 Aug; 17(4):263-72. PMID: 23357028.
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    70. Krystal AD, Benca RM, Kilduff TS. Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. J Clin Psychiatry. 2013; 74 Suppl 1:3-20. PMID: 24107804.
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    71. Krystal AD. Psychiatric disorders and sleep. Neurol Clin. 2012 Nov; 30(4):1389-413. PMID: 23099143; PMCID: PMC3493205.
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    72. Rosenquist PB, Krystal A, Heart KL, Demitrack MA, McCall WV. Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder. Psychiatry Res. 2013 Jan 30; 205(1-2):67-73. PMID: 23021320.
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    73. Preud'homme XA, Amundsen CL, Webster GD, Krystal AD. Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls. Int Urogynecol J. 2013 Mar; 24(3):501-8. PMID: 22855113.
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    74. Krystal AD, Roth T, Simon RD. Shift work disorder case studies: applying management principles in clinical practice. J Clin Psychiatry. 2012 Aug; 73(8):e25. PMID: 22967784.
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    75. Krystal AD, McCall WV, Fava M, Joffe H, Soares CN, Huang H, Grinell T, Zummo J, Spalding W, Marshall R. Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity. Prim Care Companion CNS Disord. 2012; 14(4). PMID: 23251857; PMCID: PMC3505126.
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    76. Low Y, Goforth HW, Omonuwa T, Preud'homme X, Edinger J, Krystal A. Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients. Clin Neurophysiol. 2012 Dec; 123(12):2402-5. PMID: 22727712.
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    77. Krystal AD, Sutherland J, Hochman DW. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012; 7(4):e35417. PMID: 22514741; PMCID: PMC3325958.
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    78. Flink BJ, Rivelli SK, Cox EA, White WD, Falcone G, Vail TP, Young CC, Bolognesi MP, Krystal AD, Trzepacz PT, Moon RE, Kwatra MM. Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly. Anesthesiology. 2012 Apr; 116(4):788-96. PMID: 22337162; PMCID: PMC3321273.
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    79. Krystal AD, Huang H, Zummo J, Grinnell T, Marshall RD. A WASO sub-group analysis of a 6-month study of eszopiclone 3 mg. Sleep Med. 2012 Jun; 13(6):691-6. PMID: 22465450.
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    80. Carney CE, Buysse DJ, Ancoli-Israel S, Edinger JD, Krystal AD, Lichstein KL, Morin CM. The consensus sleep diary: standardizing prospective sleep self-monitoring. Sleep. 2012 Feb 01; 35(2):287-302. PMID: 22294820; PMCID: PMC3250369.
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    81. Krystal AD. How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder. J Clin Psychiatry. 2012 Feb; 73(2):e05. PMID: 22401482.
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    82. Palmese LB, DeGeorge PC, Ratliff JC, Srihari VH, Wexler BE, Krystal AD, Tek C. Insomnia is frequent in schizophrenia and associated with night eating and obesity. Schizophr Res. 2011 Dec; 133(1-3):238-43. PMID: 21856129.
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    83. Low Y, Preud'homme X, Goforth HW, Omonuwa T, Krystal AD. The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study. Sleep. 2011 Dec 01; 34(12):1723-6. PMID: 22131611; PMCID: PMC3208851.
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    84. Krystal AD, Lankford A, Durrence HH, Ludington E, Jochelson P, Rogowski R, Roth T. Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. Sleep. 2011 Oct 01; 34(10):1433-42. PMID: 21966075; PMCID: PMC3174845.
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    85. Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud'homme X, Krystal AD. Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes. Biol Psychiatry. 2011 Oct 15; 70(8):794-9. PMID: 21762878.
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    86. Edinger JD, Wyatt JK, Stepanski EJ, Olsen MK, Stechuchak KM, Carney CE, Chiang A, Crisostomo MI, Lineberger MD, Means MK, Radtke RA, Wohlgemuth WK, Krystal AD. Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis. Arch Gen Psychiatry. 2011 Oct; 68(10):992-1002. PMID: 21646568.
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    87. Carney CE, Moss TG, Harris AL, Edinger JD, Krystal AD. Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients? J Psychiatr Res. 2011 Sep; 45(9):1243-9. PMID: 21482427; PMCID: PMC3157494.
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    88. Richey SM, Krystal AD. Pharmacological advances in the treatment of insomnia. Curr Pharm Des. 2011; 17(15):1471-5. PMID: 21476952.
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    89. Krystal AD. Antidepressant and Antipsychotic Drugs. Sleep Med Clin. 2010 Dec 01; 5(4):571-589. PMID: 21499530.
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    90. Krystal AD, Durrence HH, Scharf M, Jochelson P, Rogowski R, Ludington E, Roth T. Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. Sleep. 2010 Nov; 33(11):1553-61. PMID: 21102997; PMCID: PMC2954705.
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    91. Flynn KE, Shelby RA, Mitchell SA, Fawzy MR, Hardy NC, Husain AM, Keefe FJ, Krystal AD, Porter LS, Reeve BB, Weinfurt KP. Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)). Psychooncology. 2010 Oct; 19(10):1086-93. PMID: 20013938; PMCID: PMC2888823.
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    92. Krystal AD, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A. The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia. J Clin Sleep Med. 2010 Aug 15; 6(4):315-21. PMID: 20726278; PMCID: PMC2919660.
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    93. McCall WV, Blocker JN, D'Agostino R, Kimball J, Boggs N, Lasater B, Haskett R, Krystal A, McDonald WM, Rosenquist PB. Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression. J Clin Sleep Med. 2010 Aug 15; 6(4):322-9. PMID: 20726279; PMCID: PMC2919661.
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    94. Janicak PG, Nahas Z, Lisanby SH, Solvason HB, Sampson SM, McDonald WM, Marangell LB, Rosenquist P, McCall WV, Kimball J, O'Reardon JP, Loo C, Husain MH, Krystal A, Gilmer W, Dowd SM, Demitrack MA, Schatzberg AF. Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study. Brain Stimul. 2010 Oct; 3(4):187-99. PMID: 20965447.
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    95. Krystal AD. In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications. Sleep. 2010 Jul; 33(7):859-60. PMID: 20614842; PMCID: PMC2894424.
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    96. Krystal AD, Preud'homme XA, Amundsen CL, Webster GD. Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study. J Urol. 2010 Aug; 184(2):623-8. PMID: 20639027.
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    97. Krystal AD, Edinger JD. Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia. Sleep. 2010 May; 33(5):669-77. PMID: 20469809; PMCID: PMC2864882.
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    98. Ancoli-Israel S, Krystal AD, McCall WV, Schaefer K, Wilson A, Claus R, Rubens R, Roth T. A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia. Sleep. 2010 Feb; 33(2):225-34. PMID: 20175406; PMCID: PMC2817909.
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    99. Ohayon MM, Krystal A, Roehrs TA, Roth T, Vitiello MV. Using difficulty resuming sleep to define nocturnal awakenings. Sleep Med. 2010 Mar; 11(3):236-41. PMID: 20075004; PMCID: PMC2830306.
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    100. Krystal AD, Harsh JR, Yang R, Yang RR, Rippon GA, Lankford DA. A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression. J Clin Psychiatry. 2010 Jan; 71(1):32-40. PMID: 20051221.
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    101. Krystal AD. The treatment of primary insomnia. CNS Spectr. 2009 Dec; 14(12 Suppl 13):6-10. PMID: 20448512.
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    102. Omonuwa TS, Goforth HW, Preud'homme X, Krystal AD. The pharmacologic management of insomnia in patients with HIV. J Clin Sleep Med. 2009 Jun 15; 5(3):251-62. PMID: 19960648; PMCID: PMC2699172.
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    103. Krystal AD. A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice. Sleep Med Rev. 2009 Aug; 13(4):265-74. PMID: 19153052.
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    104. Preud'homme XA, Lanquart JP, Krystal AD, Bogaerts P, Linkowski P. Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep? Clin Neurophysiol. 2008 Dec; 119(12):2753-61. PMID: 18986831.
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    105. Carney CE, Ulmer C, Edinger JD, Krystal AD, Knauss F. Assessing depression symptoms in those with insomnia: an examination of the beck depression inventory second edition (BDI-II). J Psychiatr Res. 2009 Feb; 43(5):576-82. PMID: 18954876; PMCID: PMC2677199.
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    106. Krystal AD, Edinger JD. Measuring sleep quality. Sleep Med. 2008 Sep; 9 Suppl 1:S10-7. PMID: 18929313.
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    107. Lisanby SH, Husain MM, Rosenquist PB, Maixner D, Gutierrez R, Krystal A, Gilmer W, Marangell LB, Aaronson S, Daskalakis ZJ, Canterbury R, Richelson E, Sackeim HA, George MS. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology. 2009 Jan; 34(2):522-34. PMID: 18704101.
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    108. Edinger JD, Means MK, Carney CE, Krystal AD. Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia. Sleep. 2008 May; 31(5):599-607. PMID: 18517030; PMCID: PMC2398751.
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    109. Krystal AD, Goforth HW, Roth T. Effects of antipsychotic medications on sleep in schizophrenia. Int Clin Psychopharmacol. 2008 May; 23(3):150-60. PMID: 18408529.
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    110. Pollack M, Kinrys G, Krystal A, McCall WV, Roth T, Schaefer K, Rubens R, Roach J, Huang H, Krishnan R. Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Arch Gen Psychiatry. 2008 May; 65(5):551-62. PMID: 18458207.
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    111. Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15; 63(8):725-7. PMID: 18371494.
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    112. Chiang A, Krystal A. Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent. J Clin Sleep Med. 2008 Apr 15; 4(2):155-6. PMID: 18468314; PMCID: PMC2335395.
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    113. Krystal AD, Erman M, Zammit GK, Soubrane C, Roth T. Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study. Sleep. 2008 Jan; 31(1):79-90. PMID: 18220081; PMCID: PMC2225552.
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    114. Krystal AD, Thakur M, Roth T. Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia. Ann Clin Psychiatry. 2008 Jan-Mar; 20(1):39-46. PMID: 18297585.
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    115. Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Züchner S, Siegler IC, Barefoot JC, Ballard EL, Gwyther LP, Williams RB. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med. 2007 Sep-Oct; 69(7):621-4. PMID: 17766685.
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    116. Walsh JK, Krystal AD, Amato DA, Rubens R, Caron J, Wessel TC, Schaefer K, Roach J, Wallenstein G, Roth T. Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations. Sleep. 2007 Aug; 30(8):959-68. PMID: 17702264; PMCID: PMC1978384.
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    117. Roth T, Krystal AD, Lieberman JA. Long-term issues in the treatment of sleep disorders. CNS Spectr. 2007 Jul; 12(7 Suppl 10):1-14. PMID: 17603408.
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    118. Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Züchner S, Ashley-Koch A, Barefoot JC, Williams RB. Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med. 2007 Jun; 69(5):396-401. PMID: 17585061; PMCID: PMC2777888.
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    119. Lim L, Krystal A. Psychotic disorder in a patient with central and extrapontine myelinolysis. Psychiatry Clin Neurosci. 2007 Jun; 61(3):320-2. PMID: 17472602.
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    120. Krystal AD, Davidson JR. The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 2007 Apr 15; 61(8):925-7. PMID: 17397667.
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    121. Krystal AD. Treating the health, quality of life, and functional impairments in insomnia. J Clin Sleep Med. 2007 Feb 15; 3(1):63-72. PMID: 17557457.
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    122. Krystal A, Fava M, Rubens R, Wessel T, Caron J, Wilson P, Roth T, McCall WV. Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. J Clin Sleep Med. 2007 Feb 15; 3(1):48-55. PMID: 17557453.
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    123. Carney CE, Segal ZV, Edinger JD, Krystal AD. A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder. J Clin Psychiatry. 2007 Feb; 68(2):254-60. PMID: 17335324.
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    124. Krystal AD. Sleep and psychiatric disorders: future directions. Psychiatr Clin North Am. 2006 Dec; 29(4):1115-30; abstract xi. PMID: 17118285.
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    125. Zammit GK, Corser B, Doghramji K, Fry JM, James S, Krystal A, Mangano RM. Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening. J Clin Sleep Med. 2006 Oct 15; 2(4):417-23. PMID: 17557470.
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    126. McCall WV, Erman M, Krystal AD, Rosenberg R, Scharf M, Zammit GK, Wessel T. A polysomnography study of eszopiclone in elderly patients with insomnia. Curr Med Res Opin. 2006 Sep; 22(9):1633-42. PMID: 16968566.
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    127. Fava M, McCall WV, Krystal A, Wessel T, Rubens R, Caron J, Amato D, Roth T. Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol Psychiatry. 2006 Jun 01; 59(11):1052-60. PMID: 16581036.
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    128. Walsh JK, Perlis M, Rosenthal M, Krystal A, Jiang J, Roth T. Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia. J Clin Sleep Med. 2006 Jan 15; 2(1):35-41. PMID: 17557435.
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    129. Edinger JD, Wohlgemuth WK, Krystal AD, Rice JR. Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial. Arch Intern Med. 2005 Nov 28; 165(21):2527-35. PMID: 16314551.
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    130. Roth T, Walsh JK, Krystal A, Wessel T, Roehrs TA. An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Med. 2005 Nov; 6(6):487-95. PMID: 16230048.
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    131. Krystal AD. The effect of insomnia definitions, terminology, and classifications on clinical practice. J Am Geriatr Soc. 2005 Jul; 53(7 Suppl):S258-63. PMID: 15982374.
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    132. Wohlgemuth WK, Krystal AD. Hypnotics should be considered for the initial treatment of chronic insomnia. Pro. J Clin Sleep Med. 2005 Apr 15; 1(2):120-4. PMID: 17561623.
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    133. Krystal AD. The possibility of preventing functional impairment due to sleep loss by pharmacologically enhancing sleep. Sleep. 2005 Jan; 28(1):16-7. PMID: 15700715.
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    134. Perlis ML, McCall WV, Krystal AD, Walsh JK. Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia. J Clin Psychiatry. 2004 Aug; 65(8):1128-37. PMID: 15323600.
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    135. Singh J, Zarate CA, Krystal AD. Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine. Psychopharmacology (Berl). 2004 Apr; 173(1-2):227-8. PMID: 14722708.
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    136. Ancoli-Israel S, Benca RM, Edinger JD, Krystal AD, Mendelson W, Moldofsky H, Petrie J, Roth T, Walsh JK, Winkelman J. Panel discussion: changing how we think about insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:44-6. PMID: 15153067.
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    137. Krystal AD, Roth T. Introduction: Definitions, measurements, and management in insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:5-7. PMID: 15153061.
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    138. Krystal AD. The changing perspective on chronic insomnia management. J Clin Psychiatry. 2004; 65 Suppl 8:20-5. PMID: 15153064.
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    139. Krystal AD. Depression and insomnia in women. Clin Cornerstone. 2004; 6 Suppl 1B:S19-28. PMID: 15457812.
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    140. Krystal AD, Walsh JK, Laska E, Caron J, Amato DA, Wessel TC, Roth T. Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep. 2003 Nov 01; 26(7):793-9. PMID: 14655910.
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    141. Edinger JD, Krystal AD. Subtyping primary insomnia: is sleep state misperception a distinct clinical entity? Sleep Med Rev. 2003 Jun; 7(3):203-14. PMID: 12927120.
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    142. Krystal AD, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA, Falcone G, Coffey CE. Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci. 2003; 15(1):27-34. PMID: 12556568.
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    143. Krystal AD. Insomnia in women. Clin Cornerstone. 2003; 5(3):41-50. PMID: 14626540.
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    144. Krystal AD, Edinger JD, Wohlgemuth WK, Marsh GR. NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep. 2002 Sep 15; 25(6):630-40. PMID: 12224842.
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    145. Krystal AD, Weiner RD. Low-Frequency Ictal EEG Activity and ECT Therapeutic Impact. Convuls Ther. 1993; 9(3):220-224. PMID: 11941217.
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