Andrew Krystal, MD

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
Address401 Parnassus Ave., #282
San Francisco CA 94143
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    M.I.T. B.S.E.1983Mechanical Engineering
    M.I.T.M.S.1983Biomedical Engineering
    Duke UniversityM.D.1987Medicine
    Duke UniversityResidency1991Psychiatry
    Duke UniversityExecutive Chief Residency1991Psychiatry
    Duke University/NIMHFellowship1992Sleep Disorders and Clinical Neurophysiology
    Duke UniversityFellowship1993Clinical Research Methodology

    Collapse Overview 
    Collapse Overview
    Dr. Krystal is the Ray and Dagmar Dolby Distinguished Professor in the Departments of Psychiatry and Neurology, Vice-Chair for Research in the Department of Psychiatry, Director of the Dolby Family Center for Mood Disorders, Director of the UCSF Interventional Psychiatry Program and Co-Director of the TMS & Neuromodulation Clinic. He is Board Certified in Clinical Neurophysiology by the American Board of Clinical Neurophysiology and the American Board of Psychiatry and Neurology and Board Certified in Psychiatry by the American Board of Psychiatry and Neurology. He is a pioneer in the application of computational modeling to the study of biomarker development using EEG in patients with depression and sleep disorders and application of biomarkers in treatment development clinical trials. He also has extensive experience in clinical and research personalization of therapies for the treatment of patients with mood disorders. He has been the principal investigator of more than 50 single-site and multi-site clinical trials.

    Collapse Research 
    Collapse Research Activities and Funding
    Tissue-Specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia
    NIH R01DK117953Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear
    NIH R21MH106772Apr 15, 2015 - Jan 31, 2019
    Role: Principal Investigator
    Instrument to Co-register EEG and NIRS for Accurate Sleep Sorting
    NIH R21NS085818Sep 22, 2014 - Feb 28, 2018
    Role: Co-Principal Investigator
    2/3-Reducing Suicide Ideation Through Insomnia Treatment (REST-IT)
    NIH R01MH095780Aug 3, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Nocturnal Deterusor Overactivity In Overactive Bladder Syndrome
    NIH R01DK087717Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Biomarkers of the Response to CBT for Insomnia in Major Depression
    NIH R01HL096492Oct 1, 2009 - Jul 31, 2014
    Role: Principal Investigator
    3/3-Improving Depression Outcome by Adding CBT for Insomnia to Antidepressants
    NIH R01MH079256Jun 1, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Behavioral Insomnia Treatment in Chronic Fatigue Syndrome
    NIH R21NR010539Jul 20, 2007 - May 31, 2009
    Role: Principal Investigator
    OPTIMIZING ECT STIMULUS DOSING USING THE ICTAL EEG
    NIH R29MH057532May 1, 1998 - Feb 28, 2004
    Role: Principal Investigator
    IMPROVING ECT EFFECTIVENESS THROUGH ICTAL EEG ANALYSIS
    NIH K20MH001151Apr 1, 1994 - Mar 31, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Do Insomnia Treatments Improve Daytime Function? J Clin Med. 2023 Apr 24; 12(9). Watson NF, Bertisch SM, Morin CM, Pelayo R, Winkelman JW, Zee PC, Krystal AD. PMID: 37176529; PMCID: PMC10179344.
      View in: PubMed   Mentions: 1  
    2. Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal. J Clin Med. 2023 Apr 18; 12(8). Pelayo R, Bertisch SM, Morin CM, Winkelman JW, Zee PC, Krystal AD. PMID: 37109268; PMCID: PMC10146758.
      View in: PubMed   Mentions: 1  
    3. Wake Up America: National Survey of Patients' and Physicians' Views and Attitudes on Insomnia Care. J Clin Med. 2023 Mar 25; 12(7). Benca RM, Bertisch SM, Ahuja A, Mandelbaum R, Krystal AD. PMID: 37048582; PMCID: PMC10094753.
      View in: PubMed   Mentions:
    4. Alliance for Sleep Clinical Practice Guideline on Switching or Deprescribing Hypnotic Medications for Insomnia. J Clin Med. 2023 Mar 25; 12(7). Watson NF, Benca RM, Krystal AD, McCall WV, Neubauer DN. PMID: 37048577; PMCID: PMC10095217.
      View in: PubMed   Mentions: 1  
    5. What Should Be the Focus of Treatment When Insomnia Disorder Is Comorbid with Depression or Anxiety Disorder? J Clin Med. 2023 Mar 02; 12(5). Morin CM, Bertisch SM, Pelayo R, Watson NF, Winkelman JW, Zee PC, Krystal AD. PMID: 36902762; PMCID: PMC10004168.
      View in: PubMed   Mentions: 1  
    6. Objective sleep duration and response to combined pharmacotherapy and cognitive behavioral insomnia therapy among patients with comorbid depression and insomnia: a report from the TRIAD study. J Clin Sleep Med. 2023 Feb 17. Edinger JD, Smith ED, Buysse DJ, Thase M, Krystal AD, Wiskniewski S, Manber R. PMID: 36798983.
      View in: PubMed   Mentions:    Fields:    
    7. Long-Term Use of Insomnia Medications: An Appraisal of the Current Clinical and Scientific Evidence. J Clin Med. 2023 Feb 17; 12(4). Zee PC, Bertisch SM, Morin CM, Pelayo R, Watson NF, Winkelman JW, Krystal AD. PMID: 36836164; PMCID: PMC9959182.
      View in: PubMed   Mentions: 1  
    8. Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations. Brain Stimul. 2023 Feb 10; 16(2):462-465. Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD. PMID: 36773780.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Changes in intracranial neurophysiology associated with acute COVID-19 infection. Clin Neurophysiol. 2023 04; 148:29-31. Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD. PMID: 36791656; PMCID: PMC9896881.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Recognition and Management of Obstructive Sleep Apnea in Psychiatric Practice. J Clin Psychiatry. 2023 01 23; 84(2). Benca RM, Krystal A, Chepke C, Doghramji K. PMID: 36700835.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Longitudinal study to assess antidepressant treatment patterns and outcomes in individuals with depression in the general population. J Affect Disord. 2023 01 15; 321:272-278. Ohayon MM, McCue M, Krystal A, Selzler KJ, Chrones L, Lawrence D, Côté ML. PMID: 36280197.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Publisher Correction: State-dependent responses to intracranial brain stimulation in a patient with depression. Nat Med. 2022 Oct; 28(10):2218. Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD. PMID: 35941379.
      View in: PubMed   Mentions:    Fields:    
    13. Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program. J Affect Disord. 2023 01 01; 320:353-359. Epperson CN, Rubinow DR, Meltzer-Brody S, Deligiannidis KM, Riesenberg R, Krystal AD, Bankole K, Huang MY, Li H, Brown C, Kanes SJ, Lasser R. PMID: 36191643.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. International Consensus Statement on Obstructive Sleep Apnea. Int Forum Allergy Rhinol. 2022 Sep 06. Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, Cahali MB, Cai Y, Cao M, Capasso R, Caples SM, Chahine LM, Chang CP, Chang KW, Chaudhary N, Cheong CSJ, Chowdhuri S, Cistulli PA, Claman D, Collen J, Coughlin KC, Creamer J, Davis EM, Dupuy-McCauley KL, Durr ML, Dutt M, Ali ME, Elkassabany NM, Epstein LJ, Fiala JA, Freedman N, Gill K, Gillespie MB, Golisch L, Gooneratne N, Gottlieb DJ, Green KK, Gulati A, Gurubhagavatula I, Hayward N, Hoff PT, Hoffmann OMG, Holfinger SJ, Hsia J, Huntley C, Huoh KC, Huyett P, Inala S, Ishman SL, Jella TK, Jobanputra AM, Johnson AP, Junna MR, Kado JT, Kaffenberger TM, Kapur VK, Kezirian EJ, Khan M, Kirsch DB, Kominsky A, Kryger M, Krystal AD, Kushida CA, Kuzniar TJ, Lam DJ, Lettieri CJ, Lim DC, Lin HC, Liu SYC, MacKay SG, Magalang UJ, Malhotra A, Mansukhani MP, Maurer JT, May AM, Mitchell RB, Mokhlesi B, Mullins AE, Nada EM, Naik S, Nokes B, Olson MD, Pack AI, Pang EB, Pang KP, Patil SP, Van de Perck E, Piccirillo JF, Pien GW, Piper AJ, Plawecki A, Quigg M, Ravesloot MJL, Redline S, Rotenberg BW, Ryden A, Sarmiento KF, Sbeih F, Schell AE, Schmickl CN, Schotland HM, Schwab RJ, Seo J, Shah N, Shelgikar AV, Shochat I, Soose RJ, Steele TO, Stephens E, Stepnowsky C, Strohl KP, Sutherland K, Suurna MV, Thaler E, Thapa S, Vanderveken OM, de Vries N, Weaver EM, Weir ID, Wolfe LF, Woodson BT, Won CHJ, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu JL, Zeidler M, Rosen IM. PMID: 36068685.
      View in: PubMed   Mentions: 2     Fields:    
    15. Solriamfetol treatment of excessive daytime sleepiness in participants with narcolepsy or obstructive sleep apnea with a history of depression. J Psychiatr Res. 2022 Nov; 155:202-210. Krystal AD, Benca RM, Rosenberg R, Schweitzer PK, Malhotra A, Babson K, Lee L, Bujanover S, Strohl KP. PMID: 36070638; PMCID: PMC9718635.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention. Glob Adv Health Med. 2022; 11:2164957X221087655. Felder JN, Mirchandaney R, Harrison J, Manber R, Cuneo J, Krystal A, Epel E, Hecht F. PMID: 35360508; PMCID: PMC8961353.
      View in: PubMed   Mentions: 1  
    17. Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls. Nat Sci Sleep. 2022; 14:217-230. Lunsford-Avery JR, Edinger JD, Krystal AD. PMID: 35210889; PMCID: PMC8860757.
      View in: PubMed   Mentions:
    18. Randomized controlled trial of digital cognitive behavior therapy for prenatal insomnia symptoms: effects on postpartum insomnia and mental health. Sleep. 2022 02 14; 45(2). Felder JN, Epel ES, Neuhaus J, Krystal AD, Prather AA. PMID: 34850238; PMCID: PMC8842335.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Links between the brain and body during sleep: implications for memory processing. Trends Neurosci. 2022 03; 45(3):212-223. Whitehurst LN, Subramoniam A, Krystal A, Prather AA. PMID: 35074220.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Telemedicine-delivered cognitive-behavioral therapy for insomnia in alcohol use disorder (AUD): study protocol for a randomized controlled trial. Trials. 2022 Jan 20; 23(1):59. Arnedt JT, Cardoni ME, Conroy DA, Graham M, Amin S, Bohnert KM, Krystal AD, Ilgen MA. PMID: 35057834; PMCID: PMC8771184.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    21. Trajectories of Insomnia in Adults After Traumatic Brain Injury. JAMA Netw Open. 2022 01 04; 5(1):e2145310. Wickwire EM, Albrecht JS, Capaldi VF, Jain SO, Gardner RC, Werner JK, Mukherjee P, McKeon AB, Smith MT, Giacino JT, Nelson LD, Williams SG, Collen J, Sun X, Schnyer DM, Markowitz AJ, Manley GT, Krystal AD, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. PMID: 35080600; PMCID: PMC8792888.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. What Is Insomnia? JAMA. 2021 12 21; 326(23):2444. Krystal AD, Ashbrook LH, Prather AA. PMID: 34932076.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials. Mol Psychiatry. 2022 03; 27(3):1286-1299. Sforzini L, Worrell C, Kose M, Anderson IM, Aouizerate B, Arolt V, Bauer M, Baune BT, Blier P, Cleare AJ, Cowen PJ, Dinan TG, Fagiolini A, Ferrier IN, Hegerl U, Krystal AD, Leboyer M, McAllister-Williams RH, McIntyre RS, Meyer-Lindenberg A, Miller AH, Nemeroff CB, Normann C, Nutt D, Pallanti S, Pani L, Penninx BWJH, Schatzberg AF, Shelton RC, Yatham LN, Young AH, Zahn R, Aislaitner G, Butlen-Ducuing F, Fletcher C, Haberkamp M, Laughren T, Mäntylä FL, Schruers K, Thomson A, Arteaga-Henríquez G, Benedetti F, Cash-Gibson L, Chae WR, De Smedt H, Gold SM, Hoogendijk WJG, Mondragón VJ, Maron E, Martynowicz J, Melloni E, Otte C, Perez-Fuentes G, Poletti S, Schmidt ME, van de Ketterij E, Woo K, Flossbach Y, Ramos-Quiroga JA, Savitz AJ, Pariante CM. PMID: 34907394; PMCID: PMC9095475.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    24. Correction to: Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS). Neuropsychopharmacology. 2021 Nov; 46(12):2224. Pizzagalli DA, Smoski M, Ang YS, Whitton AE, Sanacora G, Mathew SJ, Nurnberger J, Lisanby SH, Iosifescu DV, Murrough JW, Yang H, Weiner RD, Calabrese JR, Goodman W, Potter WZ, Krystal AD. PMID: 34389811; PMCID: PMC8505431.
      View in: PubMed   Mentions:    Fields:    
    25. Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology. Front Hum Neurosci. 2021; 15:746499. Scangos KW, Khambhati AN, Daly PM, Owen LW, Manning JR, Ambrose JB, Austin E, Dawes HE, Krystal AD, Chang EF. PMID: 34744662; PMCID: PMC8566975.
      View in: PubMed   Mentions: 3  
    26. Closed-loop neuromodulation in an individual with treatment-resistant depression. Nat Med. 2021 10; 27(10):1696-1700. Scangos KW, Khambhati AN, Daly PM, Makhoul GS, Sugrue LP, Zamanian H, Liu TX, Rao VR, Sellers KK, Dawes HE, Starr PA, Krystal AD, Chang EF. PMID: 34608328.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    27. Diagnosing and Treating Insomnia in Adults and Older Adults. J Clin Psychiatry. 2021 09 28; 82(6). Rosenberg RP, Krystal AD. PMID: 34587376.
      View in: PubMed   Mentions: 1     Fields:    
    28. Design of the National Adaptive Trial for PTSD-related Insomnia (NAP Study), VA Cooperative Study Program (CSP) #2016. Contemp Clin Trials. 2021 10; 109:106540. Krystal JH, Chow B, Vessicchio J, Henrie AM, Neylan TC, Krystal AD, Marx BP, Xu K, Jindal RD, Davis LL, Schnurr PP, Stein MB, Thase ME, Ventura B, Huang GD, Shih MC, CSP 2016 Study Team. PMID: 34416369.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    29. Optimizing Treatment for Insomnia. J Clin Psychiatry. 2021 07 13; 82(4). Krystal AD. PMID: 34255942.
      View in: PubMed   Mentions:    Fields:    
    30. Examining suicide assessment measures for research use: Using item response theory to optimize psychometric assessment for research on suicidal ideation in major depressive disorder. Suicide Life Threat Behav. 2021 12; 51(6):1086-1094. McCall WV, Porter B, Pate AR, Bolstad CJ, Drapeau CW, Krystal AD, Benca RM, Rumble ME, Nadorff MR. PMID: 34237156.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults. JAMA Netw Open. 2021 07 01; 4(7):e2117573. Insel PS, Mohlenhoff BS, Neylan TC, Krystal AD, Mackin RS. PMID: 34297074; PMCID: PMC8303100.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Challenges in Managing Insomnia in Older People. J Clin Psychiatry. 2021 06 29; 82(4). Krystal AD. PMID: 34232584.
      View in: PubMed   Mentions:    Fields:    
    33. Evaluating lemborexant for the treatment of insomnia. Expert Opin Pharmacother. 2021 Jul; 22(10):1235-1243. Zammit G, Krystal A. PMID: 33711243.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Cost-effectiveness of digital cognitive behavioral therapy (Sleepio) for insomnia: a Markov simulation model in the United States. Sleep. 2021 04 09; 44(4). Darden M, Espie CA, Carl JR, Henry AL, Kanady JC, Krystal AD, Miller CB. PMID: 33151330.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. State-dependent responses to intracranial brain stimulation in a patient with depression. Nat Med. 2021 02; 27(2):229-231. Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD. PMID: 33462446; PMCID: PMC8284979.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    36. Correction to: Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis. J Patient Rep Outcomes. 2020 Dec 29; 4(1):107. Dias-Barbosa C, Matos R, Vernon M, Carney CE, Krystal A, Puelles J. PMID: 33373018; PMCID: PMC7772119.
      View in: PubMed   Mentions: 1  
    37. Optimizing computation of overnight decline in delta power: Evidence for slower rate of decline in delta power in insomnia patients. Clin Neurophysiol. 2021 02; 132(2):545-553. Lunsford-Avery JR, Edinger JD, Krystal AD. PMID: 33450577; PMCID: PMC7891187.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    38. Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis. J Patient Rep Outcomes. 2020 Nov 23; 4(1):100. Dias-Barbosa C, Matos R, Vernon M, Carney CE, Krystal A, Puelles J. PMID: 33226517; PMCID: PMC7683746.
      View in: PubMed   Mentions: 6  
    39. Effectiveness of Sequential Psychological and Medication Therapies for Insomnia Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2020 11 01; 77(11):1107-1115. Morin CM, Edinger JD, Beaulieu-Bonneau S, Ivers H, Krystal AD, Guay B, Bélanger L, Cartwright A, Simmons B, Lamy M, Busby M. PMID: 32639561; PMCID: PMC7344835.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    40. Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. Curr Biol. 2021 01 11; 31(1):13-24.e4. Shi G, Yin C, Fan Z, Xing L, Mostovoy Y, Kwok PY, Ashbrook LH, Krystal AD, Ptácek LJ, Fu YH. PMID: 33065013.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    41. Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study. JMIR Mhealth Uhealth. 2020 10 01; 8(10):e20590. Lunsford-Avery JR, Keller C, Kollins SH, Krystal AD, Jackson L, Engelhard MM. PMID: 33001035; PMCID: PMC7563632.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    42. Blinding and bias in a hypnotic clinical trial. Hum Psychopharmacol. 2021 01; 36(1):1-5. McCall WV, Benca RM, Rumble ME, Krystal AD. PMID: 32918323.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy. J Affect Disord. 2021 01 01; 278:288-295. Krystal AD, Mittoux A, Lindsten A, Baker RA. PMID: 32979560.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation. J Clin Sleep Med. 2020 08 15; 16(8):1311-1319. Rumble ME, McCall WV, Dickson DA, Krystal AD, Rosenquist PB, Benca RM. PMID: 32329435; PMCID: PMC7446102.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    45. Omitted Conflict of Interest Disclosures. JAMA Psychiatry. 2020 07 01; 77(7):768. Krystal AD. PMID: 32320022.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    46. Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS). Neuropsychopharmacology. 2020 09; 45(10):1656-1663. Pizzagalli DA, Smoski M, Ang YS, Whitton AE, Sanacora G, Mathew SJ, Nurnberger J, Lisanby SH, Iosifescu DV, Murrough JW, Yang H, Weiner RD, Calabrese JR, Goodman W, Potter WZ, Krystal AD. PMID: 32544925; PMCID: PMC7419512.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    47. Is cellular energy monitoring more responsive to hypoxia than pulse oximetry? Sleep Breath. 2020 Dec; 24(4):1633-1643. Hatch GM, Ashbrook L, Prather AA, Krystal AD. PMID: 32458375; PMCID: PMC7679291.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Efficacy of Digital Cognitive Behavioral Therapy for the Treatment of Insomnia Symptoms Among Pregnant Women: A Randomized Clinical Trial. JAMA Psychiatry. 2020 05 01; 77(5):484-492. Felder JN, Epel ES, Neuhaus J, Krystal AD, Prather AA. PMID: 31968068; PMCID: PMC6990703.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    49. A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia. Nat Med. 2020 05; 26(5):760-768. Krystal AD, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Calabrese JR, Sanacora G, Hermes G, Keefe RSE, Song A, Goodman W, Szabo ST, Whitton AE, Gao K, Potter WZ. PMID: 32231295; PMCID: PMC9949770.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    50. The assessment and management of insomnia: an update. World Psychiatry. 2019 Oct; 18(3):337-352. Krystal AD, Prather AA, Ashbrook LH. PMID: 31496087; PMCID: PMC6732697.
      View in: PubMed   Mentions: 38  
    51. Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial. Am J Psychiatry. 2019 11 01; 176(11):957-965. McCall WV, Benca RM, Rosenquist PB, Youssef NA, McCloud L, Newman JC, Case D, Rumble ME, Szabo ST, Phillips M, Krystal AD. PMID: 31537089; PMCID: PMC6824991.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    52. A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron. 2019 09 25; 103(6):1044-1055.e7. Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptácek LJ, Fu YH. PMID: 31473062; PMCID: PMC6763376.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    53. Genetics of the human circadian clock and sleep homeostat. Neuropsychopharmacology. 2020 01; 45(1):45-54. Ashbrook LH, Krystal AD, Fu YH, Ptácek LJ. PMID: 31400754; PMCID: PMC6879540.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    54. Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy. J Neuropsychiatry Clin Neurosci. 2020; 32(2):185-190. Scangos KW, Ahmad HS, Shafi A, Sellers KK, Dawes HE, Krystal A, Chang EF. PMID: 31394989; PMCID: PMC7429560.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    55. Sleep therapeutics and neuropsychiatric illness. Neuropsychopharmacology. 2020 01; 45(1):166-175. Krystal AD. PMID: 31376815; PMCID: PMC6879486.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    56. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update. J Psychopharmacol. 2019 08; 33(8):923-947. Wilson S, Anderson K, Baldwin D, Dijk DJ, Espie A, Espie C, Gringras P, Krystal A, Nutt D, Selsick H, Sharpley A. PMID: 31271339.
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    57. Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder. J Psychiatr Res. 2019 09; 116:147-150. McCall WV, Benca RM, Rumble ME, Case D, Rosenquist PB, Krystal AD. PMID: 31238203; PMCID: PMC6606377.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    58. Sleep Pharmacogenetics: The Promise of Precision Medicine. Sleep Med Clin. 2019 Sep; 14(3):317-331. Krystal AD, Prather AA. PMID: 31375201.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    59. An Electrophysiological Biomarker That May Predict Treatment Response to ECT. J ECT. 2019 Jun; 35(2):95-102. Scangos KW, Weiner RD, Coffey EC, Krystal AD. PMID: 30531398; PMCID: PMC6538443.
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    60. Circadian Preference as a Moderator of Depression Outcome Following Cognitive Behavioral Therapy for Insomnia Plus Antidepressant Medications: A Report From the TRIAD Study. J Clin Sleep Med. 2019 04 15; 15(4):573-580. Asarnow LD, Bei B, Krystal A, Buysse DJ, Thase ME, Edinger JD, Manber R. PMID: 30952216; PMCID: PMC6457514.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    61. Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers. J Alzheimers Dis. 2019; 67(3):911-921. La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E. PMID: 30689583; PMCID: PMC6398835.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    62. The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development. Nat Rev Drug Discov. 2018 12 28; 18(1):82-84. Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J, Szabo S, Murrough J, Shekhar A, Potter W. PMID: 30591715; PMCID: PMC6816017.
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    63. Effect of γ-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy. Int J Clin Pharmacol Ther. 2018 Dec; 56(12):620-622. Szabo ST, Kandra K, Krystal AD. PMID: 30178743.
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    64. Obstructive Sleep Apnea in Pregnant Women: A Review of Pregnancy Outcomes and an Approach to Management. Anesth Analg. 2018 11; 127(5):1167-1177. Dominguez JE, Krystal AD, Habib AS. PMID: 29649034; PMCID: PMC6733415.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    65. Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications. J Sleep Res. 2019 04; 28(2):e12782. Herring WJ, Roth T, Krystal AD, Michelson D. PMID: 30338596.
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    66. Screening extremely obese pregnant women for obstructive sleep apnea. Am J Obstet Gynecol. 2018 12; 219(6):613.e1-613.e10. Dominguez JE, Grotegut CA, Cooter M, Krystal AD, Habib AS. PMID: 30217579; PMCID: PMC6733412.
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    67. Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families. Sleep Med. 2019 01; 53:88-93. Ohayon MM, Black J, Krystal AD, Shapiro CM, Swick TJ, Bogan R, Wells CC. PMID: 30496948.
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    68. An Ultra-miniaturized Near Infrared Spectroscopy System to Assess Sleep Apnea in Children with Down Syndrome. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:2877-2880. Beppler EC, Dieffenderfer J, Songkakul T, Krystal A, Bozkurt A. PMID: 30441002.
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    69. A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease. Sleep Med Rev. 2018 12; 42:37-46. Dominguez JE, Habib AS, Krystal AD. PMID: 29929840; PMCID: PMC6221976.
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    70. Treating insomnia in depression: Insomnia related factors predict long-term depression trajectories. J Consult Clin Psychol. 2018 03; 86(3):282-293. Bei B, Asarnow LD, Krystal A, Edinger JD, Buysse DJ, Manber R. PMID: 29504795; PMCID: PMC5841584.
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    71. Dr McClintock and Colleagues Reply. J Clin Psychiatry. 2018 Jan/Feb; 79(1). McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal A, Sampson S, Morales O, Nelson BG, George MS, Lisanby SH. PMID: 29505182.
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    72. Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression. J Clin Psychiatry. 2018 Jan/Feb; 79(1). McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, Cook IA, O'Reardon J, Husain MM, Wall C, Krystal AD, Sampson SM, Morales O, Nelson BG, Latoussakis V, George MS, Lisanby SH, National Network of Depression Centers rTMS Task Group, American Psychiatric Association Council on Research Task Force on Novel Biomarkers and Treatments. PMID: 28541649; PMCID: PMC5846193.
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    73. The relationship of person-specific eveningness chronotype, greater seasonality, and less rhythmicity to suicidal behavior: A literature review. J Affect Disord. 2018 02; 227:721-730. Rumble ME, Dickson D, McCall WV, Krystal AD, Case D, Rosenquist PB, Benca RM. PMID: 29179142; PMCID: PMC5805608.
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    74. Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. Int J Neuropsychopharmacol. 2017 08 01; 20(8):613-618. Connor KM, Ceesay P, Hutzelmann J, Snavely D, Krystal AD, Trivedi MH, Thase M, Lines C, Herring WJ, Michelson D. PMID: 28582570; PMCID: PMC5570043.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    75. Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation? Anesthesiology. 2017 08; 127(2):397-398. Goucher Miranda H, Krystal AD, Fierro MA. PMID: 28719531.
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    76. Adverse Effects of Hypnotic Medications. J Clin Sleep Med. 2017 06 15; 13(6):839. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN. PMID: 28454603; PMCID: PMC5443747.
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    77. Pilot prospective study of post-surgery sleep and EEG predictors of post-operative delirium. Clin Neurophysiol. 2017 08; 128(8):1421-1425. Evans JL, Nadler JW, Preud'homme XA, Fang E, Daughtry RL, Chapman JB, Attarian D, Wellman S, Krystal AD. PMID: 28618293.
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    78. Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial. Sleep. 2017 04 01; 40(4). Carney CE, Edinger JD, Kuchibhatla M, Lachowski AM, Bogouslavsky O, Krystal AD, Shapiro CM. PMID: 28199710; PMCID: PMC5806549.
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    79. Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials. Am J Geriatr Psychiatry. 2017 Jul; 25(7):791-802. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. PMID: 28427826.
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    80. Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data. Psychopharmacology (Berl). 2017 Jun; 234(11):1703-1711. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. PMID: 28265715.
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    81. A randomised trial of peri-operative positive airway pressure for postoperative delirium in patients at risk for obstructive sleep apnoea after regional anaesthesia with sedation or general anaesthesia for joint arthroplasty. Anaesthesia. 2017 Jun; 72(6):729-736. Nadler JW, Evans JL, Fang E, Preud'Homme XA, Daughtry RL, Chapman JB, Bolognesi MP, Attarian DE, Wellman SS, Krystal AD. PMID: 28251606.
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    82. Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study. J Clin Sleep Med. 2017 Feb 15; 13(2):205-213. Edinger JD, Manber R, Buysse DJ, Krystal AD, Thase ME, Gehrman P, Fairholme CP, Luther J, Wisniewski S. PMID: 27784414; PMCID: PMC5263076.
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    83. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017 Feb 15; 13(2):307-349. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. PMID: 27998379; PMCID: PMC5263087.
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    84. Segmented sleep in a nonelectric, small-scale agricultural society in Madagascar. Am J Hum Biol. 2017 Jul 08; 29(4). Samson DR, Manus MB, Krystal AD, Fakir E, Yu JJ, Nunn CL. PMID: 28181718.
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    85. Double-Blind, Placebo-Controlled, Crossover Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia. Sleep. 2017 Jan 01; 40(1). Krystal AD, Preud'homme XA. PMID: 28364461.
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    86. Insomnia Patients With Objective Short Sleep Duration Have a Blunted Response to Cognitive Behavioral Therapy for Insomnia. Sleep. 2017 Jan 01; 40(1). Bathgate CJ, Edinger JD, Krystal AD. PMID: 28364452; PMCID: PMC6084751.
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    87. Should Internet Cognitive Behavioral Therapy for Insomnia Be the Primary Treatment Option for Insomnia?: Toward Getting More SHUTi. JAMA Psychiatry. 2017 01 01; 74(1):15-16. Krystal AD, Prather AA. PMID: 27902827.
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    88. National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 02; 3(1):6-19. Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV. PMID: 28346153.
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    89. Sleep and Mood: Chicken or Egg? Biol Psychiatry. 2016 12 01; 80(11):810-811. Ptáoek LJ, Fu YH, Krystal AD. PMID: 27968724.
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    90. Sleep disturbances in adolescents with ADHD: A systematic review and framework for future research. Clin Psychol Rev. 2016 Dec; 50:159-174. Lunsford-Avery JR, Krystal AD, Kollins SH. PMID: 27969004; PMCID: PMC5401800.
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    91. Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial. J Clin Psychiatry. 2016 Oct; 77(10):e1316-e1323. Manber R, Buysse DJ, Edinger J, Krystal A, Luther JF, Wisniewski SR, Trockel M, Kraemer HC, Thase ME. PMID: 27788313.
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    92. Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. Depress Anxiety. 2016 10; 33(10):895-906. Carlezon WA, Krystal AD. PMID: 27699938; PMCID: PMC5288841.
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    93. Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale. Trends Pharmacol Sci. 2016 11; 37(11):933-944. Jacobsen JPR, Krystal AD, Krishnan KRR, Caron MG. PMID: 27692695; PMCID: PMC5728156.
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    94. Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials. J Clin Sleep Med. 2016 09 15; 12(9):1215-25. Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. PMID: 27397664; PMCID: PMC4990943.
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    95. Hypnotic Medications and Suicide: Risk, Mechanisms, Mitigation, and the FDA. Am J Psychiatry. 2017 Jan 01; 174(1):18-25. McCall WV, Benca RM, Rosenquist PB, Riley MA, McCloud L, Newman JC, Case D, Rumble M, Krystal AD. PMID: 27609243; PMCID: PMC5205566.
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    96. Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study. Prim Care Companion CNS Disord. 2016 Sep 08; 18(5). Krystal AD, Mittoux A, Meisels P, Baker RA. PMID: 27835722.
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    97. Hibernation in a primate: does sleep occur? R Soc Open Sci. 2016 Aug; 3(8):160282. Blanco MB, Dausmann KH, Faherty SL, Klopfer P, Krystal AD, Schopler R, Yoder AD. PMID: 27853604; PMCID: PMC5108954.
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    98. Shining evolutionary light on human sleep and sleep disorders. Evol Med Public Health. 2016; 2016(1):227-43. Nunn CL, Samson DR, Krystal AD. PMID: 27470330; PMCID: PMC4972941.
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    99. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 07 15; 80(2):84-86. Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. PMID: 27346079; PMCID: PMC6150945.
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    100. Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia. Sleep. 2016 05 01; 39(5):1037-45. Bathgate CJ, Edinger JD, Wyatt JK, Krystal AD. PMID: 26951399; PMCID: PMC4835301.
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    101. The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia. Hum Psychopharmacol. 2016 05; 31(3):206-16. Krystal AD, Zammit G. PMID: 27108672.
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    102. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504. J Clin Psychiatry. 2016 04; 77(4):483-91. Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD, Veterans Affairs Cooperative Study #504 Group. PMID: 26890894.
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    103. Recognizing and managing insomnia in primary care and specialty settings. J Clin Psychiatry. 2016 04; 77(4):e471. Krystal AD, Sorscher AJ. PMID: 27137433.
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    104. Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial. Trials. 2016 Mar 03; 17(1):118. Morin CM, Edinger JD, Krystal AD, Buysse DJ, Beaulieu-Bonneau S, Ivers H. PMID: 26940892; PMCID: PMC4778294.
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    105. New Developments in Insomnia Medications of Relevance to Mental Health Disorders. Psychiatr Clin North Am. 2015 Dec; 38(4):843-60. Krystal AD. PMID: 26600112; PMCID: PMC5972036.
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    106. Insomnia disorder. Nat Rev Dis Primers. 2015 09 03; 1:15026. Morin CM, Drake CL, Harvey AG, Krystal AD, Manber R, Riemann D, Spiegelhalder K. PMID: 27189779.
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    107. Current, emerging, and newly available insomnia medications. J Clin Psychiatry. 2015 Aug; 76(8):e1045. Krystal AD. PMID: 26335094.
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    108. Restricting Benzodiazepines to Short-Term Prescription. JAMA Psychiatry. 2015 Jul; 72(7):734-5. Krystal JH, Stossel S, Krystal AD. PMID: 25923129.
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    109. Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression. Brain Stimul. 2015 Jul-Aug; 8(4):787-94. Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O'Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS. PMID: 26143022.
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    110. Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy. Neuropsychopharmacology. 2015 Aug; 40(9):2076-84. Peterchev AV, Krystal AD, Rosa MA, Lisanby SH. PMID: 25920013; PMCID: PMC4613599.
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    111. Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial. Sleep Med. 2015 Jul; 16(7):838-44. Ivgy-May N, Ruwe F, Krystal A, Roth T. PMID: 26047892.
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    112. A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety. Clin Trials. 2015 Jun; 12(3):189-98. McCall WV, Benca RM, Rosenquist PB, Riley MA, Hodges C, Gubosh B, McCloud L, Newman JC, Case D, Rumble M, Mayo M, White KH, Phillips M, Krystal AD. PMID: 25733676; PMCID: PMC4424155.
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    113. Traumatic brain injury detection using electrophysiological methods. Front Hum Neurosci. 2015; 9:11. Rapp PE, Keyser DO, Albano A, Hernandez R, Gibson DB, Zambon RA, Hairston WD, Hughes JD, Krystal A, Nichols AS. PMID: 25698950; PMCID: PMC4316720.
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    114. The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial. Schizophr Res. 2014 Dec; 160(1-3):180-5. Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. PMID: 25454802; PMCID: PMC5589464.
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    115. Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials. Biol Psychiatry. 2016 Jan 15; 79(2):136-48. Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D. PMID: 25526970.
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    116. Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord. 2014 Oct; 168:439-51. Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, Macfadden W, Marin R, Nierenberg AA, Tohen M. PMID: 25113957.
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    117. Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. J ECT. 2014 Jun; 30(2):165-76. McClintock SM, Choi J, Deng ZD, Appelbaum LG, Krystal AD, Lisanby SH. PMID: 24820942; PMCID: PMC4143898.
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    118. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain. Sleep. 2014 Jun 01; 37(6):1053-60. Goforth HW, Preud'homme XA, Krystal AD. PMID: 24882900; PMCID: PMC4015379.
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    119. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 May; 13(5):461-71. Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ. PMID: 24680372.
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    120. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. PMID: 24532997; PMCID: PMC3899316.
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    121. Insomnia in HIV-infected patients: pathophysiologic implications. AIDS Rev. 2014 Jan-Mar; 16(1):3-13. Low Y, Goforth H, Preud'homme X, Edinger J, Krystal A. PMID: 24522778.
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    122. The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks. J Psychopharmacol. 2014 May; 28(5):457-65. Krystal AD, Zhang W, Davidson JR, Connor KM. PMID: 24288237.
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    123. Therapeutic approaches for shankopathies. Dev Neurobiol. 2014 Feb; 74(2):123-35. Wang X, Bey AL, Chung L, Krystal AD, Jiang YH. PMID: 23536326; PMCID: PMC3883807.
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    124. The relationship of sleep with temperature and metabolic rate in a hibernating primate. PLoS One. 2013; 8(9):e69914. Krystal AD, Schopler B, Kobbe S, Williams C, Rakatondrainibe H, Yoder AD, Klopfer P. PMID: 24023713; PMCID: PMC3762832.
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    125. Optimizing the Pharmacologic Treatment of Insomnia: Current Status and Future Horizons. Sleep Med Clin. 2013 Sep 01; 8(3):333-350. Minkel J, Krystal AD. PMID: 24015116; PMCID: PMC3763861.
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    126. Does physiological hyperarousal enhance error rates among insomnia sufferers? Sleep. 2013 Aug 01; 36(8):1179-86. Edinger JD, Means MK, Krystal AD. PMID: 23904678; PMCID: PMC3700715.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    127. Obstructive sleep apnea and delirium: exploring possible mechanisms. Sleep Breath. 2014 Mar; 18(1):19-29. Mirrakhimov AE, Brewbaker CL, Krystal AD, Kwatra MM. PMID: 23584846.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    128. Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study. Sleep. 2013 Feb 01; 36(2):189-96. Roth T, Krystal A, Steinberg FJ, Singh NN, Moline M. PMID: 23372266; PMCID: PMC3543068.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    129. Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev. 2013 Aug; 17(4):263-72. Krystal AD, Richelson E, Roth T. PMID: 23357028.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    130. Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. J Clin Psychiatry. 2013; 74 Suppl 1:3-20. Krystal AD, Benca RM, Kilduff TS. PMID: 24107804.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    131. Psychiatric disorders and sleep. Neurol Clin. 2012 Nov; 30(4):1389-413. Krystal AD. PMID: 23099143; PMCID: PMC3493205.
      View in: PubMed   Mentions: 115     Fields:    Translation:Humans
    132. Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder. Psychiatry Res. 2013 Jan 30; 205(1-2):67-73. Rosenquist PB, Krystal A, Heart KL, Demitrack MA, McCall WV. PMID: 23021320.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    133. Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls. Int Urogynecol J. 2013 Mar; 24(3):501-8. Preud'homme XA, Amundsen CL, Webster GD, Krystal AD. PMID: 22855113.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    134. Shift work disorder case studies: applying management principles in clinical practice. J Clin Psychiatry. 2012 Aug; 73(8):e25. Krystal AD, Roth T, Simon RD. PMID: 22967784.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    135. Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity. Prim Care Companion CNS Disord. 2012; 14(4). Krystal AD, McCall WV, Fava M, Joffe H, Soares CN, Huang H, Grinell T, Zummo J, Spalding W, Marshall R. PMID: 23251857; PMCID: PMC3505126.
      View in: PubMed   Mentions: 7     Fields:    
    136. Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients. Clin Neurophysiol. 2012 Dec; 123(12):2402-5. Low Y, Goforth HW, Omonuwa T, Preud'homme X, Edinger J, Krystal A. PMID: 22727712.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    137. Prevalence and comorbidity of nocturnal wandering in the U.S. adult general population. Neurology. 2012 May 15; 78(20):1583-9. Ohayon MM, Mahowald MW, Dauvilliers Y, Krystal AD, Léger D. PMID: 22585435; PMCID: PMC3467644.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    138. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012; 7(4):e35417. Krystal AD, Sutherland J, Hochman DW. PMID: 22514741; PMCID: PMC3325958.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    139. Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly. Anesthesiology. 2012 Apr; 116(4):788-96. Flink BJ, Rivelli SK, Cox EA, White WD, Falcone G, Vail TP, Young CC, Bolognesi MP, Krystal AD, Trzepacz PT, Moon RE, Kwatra MM. PMID: 22337162; PMCID: PMC3321273.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    140. A WASO sub-group analysis of a 6-month study of eszopiclone 3 mg. Sleep Med. 2012 Jun; 13(6):691-6. Krystal AD, Huang H, Zummo J, Grinnell T, Marshall RD. PMID: 22465450.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    141. The consensus sleep diary: standardizing prospective sleep self-monitoring. Sleep. 2012 Feb 01; 35(2):287-302. Carney CE, Buysse DJ, Ancoli-Israel S, Edinger JD, Krystal AD, Lichstein KL, Morin CM. PMID: 22294820; PMCID: PMC3250369.
      View in: PubMed   Mentions: 503     Fields:    Translation:Humans
    142. How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder. J Clin Psychiatry. 2012 Feb; 73(2):e05. Krystal AD. PMID: 22401482.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    143. The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study. Sleep. 2011 Dec 01; 34(12):1723-6. Low Y, Preud'homme X, Goforth HW, Omonuwa T, Krystal AD. PMID: 22131611; PMCID: PMC3208851.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    144. Insomnia is frequent in schizophrenia and associated with night eating and obesity. Schizophr Res. 2011 Dec; 133(1-3):238-43. Palmese LB, DeGeorge PC, Ratliff JC, Srihari VH, Wexler BE, Krystal AD, Tek C. PMID: 21856129; PMCID: PMC5581545.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    145. Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. Sleep. 2011 Oct 01; 34(10):1433-42. Krystal AD, Lankford A, Durrence HH, Ludington E, Jochelson P, Rogowski R, Roth T. PMID: 21966075; PMCID: PMC3174845.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    146. Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes. Biol Psychiatry. 2011 Oct 15; 70(8):794-799. Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud'homme X, Krystal AD. PMID: 21762878.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    147. Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis. Arch Gen Psychiatry. 2011 Oct; 68(10):992-1002. Edinger JD, Wyatt JK, Stepanski EJ, Olsen MK, Stechuchak KM, Carney CE, Chiang A, Crisostomo MI, Lineberger MD, Means MK, Radtke RA, Wohlgemuth WK, Krystal AD. PMID: 21646568.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    148. Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients? J Psychiatr Res. 2011 Sep; 45(9):1243-9. Carney CE, Moss TG, Harris AL, Edinger JD, Krystal AD. PMID: 21482427; PMCID: PMC3157494.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    149. Pharmacological advances in the treatment of insomnia. Curr Pharm Des. 2011; 17(15):1471-5. Richey SM, Krystal AD. PMID: 21476952.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    150. Antidepressant and Antipsychotic Drugs. Sleep Med Clin. 2010 Dec 01; 5(4):571-589. Krystal AD. PMID: 21499530; PMCID: PMC3076958.
      View in: PubMed   Mentions: 6     Fields:    
    151. Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. Sleep. 2010 Nov; 33(11):1553-61. Krystal AD, Durrence HH, Scharf M, Jochelson P, Rogowski R, Ludington E, Roth T. PMID: 21102997; PMCID: PMC2954705.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    152. Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)). Psychooncology. 2010 Oct; 19(10):1086-93. Flynn KE, Shelby RA, Mitchell SA, Fawzy MR, Hardy NC, Husain AM, Keefe FJ, Krystal AD, Porter LS, Reeve BB, Weinfurt KP. PMID: 20013938; PMCID: PMC2888823.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    153. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. J Psychopharmacol. 2010 Nov; 24(11):1577-601. Wilson SJ, Nutt DJ, Alford C, Argyropoulos SV, Baldwin DS, Bateson AN, Britton TC, Crowe C, Dijk DJ, Espie CA, Gringras P, Hajak G, Idzikowski C, Krystal AD, Nash JR, Selsick H, Sharpley AL, Wade AG. PMID: 20813762.
      View in: PubMed   Mentions: 144     Fields:    Translation:Humans
    154. Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression. J Clin Sleep Med. 2010 Aug 15; 6(4):322-9. McCall WV, Blocker JN, D'Agostino R, Kimball J, Boggs N, Lasater B, Haskett R, Krystal A, McDonald WM, Rosenquist PB. PMID: 20726279; PMCID: PMC2919661.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    155. The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia. J Clin Sleep Med. 2010 Aug 15; 6(4):315-21. Krystal AD, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A. PMID: 20726278; PMCID: PMC2919660.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    156. Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study. Brain Stimul. 2010 Oct; 3(4):187-99. Janicak PG, Nahas Z, Lisanby SH, Solvason HB, Sampson SM, McDonald WM, Marangell LB, Rosenquist P, McCall WV, Kimball J, O'Reardon JP, Loo C, Husain MH, Krystal A, Gilmer W, Dowd SM, Demitrack MA, Schatzberg AF. PMID: 20965447.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    157. In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications. Sleep. 2010 Jul; 33(7):859-60. Krystal AD. PMID: 20614842; PMCID: PMC2894424.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    158. Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study. J Urol. 2010 Aug; 184(2):623-8. Krystal AD, Preud'homme XA, Amundsen CL, Webster GD. PMID: 20639027.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    159. Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia. Sleep. 2010 May; 33(5):669-77. Krystal AD, Edinger JD. PMID: 20469809; PMCID: PMC2864882.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    160. A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia. Sleep. 2010 Feb; 33(2):225-34. Ancoli-Israel S, Krystal AD, McCall WV, Schaefer K, Wilson A, Claus R, Rubens R, Roth T. PMID: 20175406; PMCID: PMC2817909.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    161. Using difficulty resuming sleep to define nocturnal awakenings. Sleep Med. 2010 Mar; 11(3):236-41. Ohayon MM, Krystal A, Roehrs TA, Roth T, Vitiello MV. PMID: 20075004; PMCID: PMC2830306.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    162. A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression. J Clin Psychiatry. 2010 Jan; 71(1):32-40. Krystal AD, Harsh JR, Yang R, Yang RR, Rippon GA, Lankford DA. PMID: 20051221.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    163. The treatment of primary insomnia. CNS Spectr. 2009 Dec; 14(12 Suppl 13):6-10. Krystal AD. PMID: 20448512.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    164. The pharmacologic management of insomnia in patients with HIV. J Clin Sleep Med. 2009 Jun 15; 5(3):251-62. Omonuwa TS, Goforth HW, Preud'homme X, Krystal AD. PMID: 19960648; PMCID: PMC2699172.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    165. A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice. Sleep Med Rev. 2009 Aug; 13(4):265-74. Krystal AD. PMID: 19153052.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    166. Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep? Clin Neurophysiol. 2008 Dec; 119(12):2753-61. Preud'homme XA, Lanquart JP, Krystal AD, Bogaerts P, Linkowski P. PMID: 18986831.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    167. Assessing depression symptoms in those with insomnia: an examination of the beck depression inventory second edition (BDI-II). J Psychiatr Res. 2009 Feb; 43(5):576-82. Carney CE, Ulmer C, Edinger JD, Krystal AD, Knauss F. PMID: 18954876; PMCID: PMC2677199.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    168. Measuring sleep quality. Sleep Med. 2008 Sep; 9 Suppl 1:S10-7. Krystal AD, Edinger JD. PMID: 18929313.
      View in: PubMed   Mentions: 127     Fields:    Translation:Humans
    169. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology. 2009 Jan; 34(2):522-34. Lisanby SH, Husain MM, Rosenquist PB, Maixner D, Gutierrez R, Krystal A, Gilmer W, Marangell LB, Aaronson S, Daskalakis ZJ, Canterbury R, Richelson E, Sackeim HA, George MS. PMID: 18704101.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCTClinical Trials
    170. Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Arch Gen Psychiatry. 2008 May; 65(5):551-62. Pollack M, Kinrys G, Krystal A, McCall WV, Roth T, Schaefer K, Rubens R, Roach J, Huang H, Krishnan R. PMID: 18458207.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    171. Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia. Sleep. 2008 May; 31(5):599-607. Edinger JD, Means MK, Carney CE, Krystal AD. PMID: 18517030; PMCID: PMC2398751.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    172. Effects of antipsychotic medications on sleep in schizophrenia. Int Clin Psychopharmacol. 2008 May; 23(3):150-60. Krystal AD, Goforth HW, Roth T. PMID: 18408529.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    173. Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent. J Clin Sleep Med. 2008 Apr 15; 4(2):155-6. Chiang A, Krystal A. PMID: 18468314; PMCID: PMC2335395.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    174. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15; 63(8):725-7. Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. PMID: 18371494.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    175. Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia. Ann Clin Psychiatry. 2008 Jan-Mar; 20(1):39-46. Krystal AD, Thakur M, Roth T. PMID: 18297585.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    176. Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study. Sleep. 2008 Jan; 31(1):79-90. Krystal AD, Erman M, Zammit GK, Soubrane C, Roth T, ZOLONG Study Group. PMID: 18220081; PMCID: PMC2225552.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    177. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med. 2007 Sep-Oct; 69(7):621-4. Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Züchner S, Siegler IC, Barefoot JC, Ballard EL, Gwyther LP, Williams RB. PMID: 17766685; PMCID: PMC2758820.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    178. Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations. Sleep. 2007 Aug; 30(8):959-68. Walsh JK, Krystal AD, Amato DA, Rubens R, Caron J, Wessel TC, Schaefer K, Roach J, Wallenstein G, Roth T. PMID: 17702264; PMCID: PMC1978384.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    179. Long-term issues in the treatment of sleep disorders. CNS Spectr. 2007 Jul; 12(7 Suppl 10):1-14. Roth T, Krystal AD, Lieberman JA. PMID: 17603408.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    180. Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med. 2007 Jun; 69(5):396-401. Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Züchner S, Ashley-Koch A, Barefoot JC, Williams RB. PMID: 17585061; PMCID: PMC2777888.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    181. Psychotic disorder in a patient with central and extrapontine myelinolysis. Psychiatry Clin Neurosci. 2007 Jun; 61(3):320-2. Lim L, Krystal A. PMID: 17472602.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    182. The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 2007 Apr 15; 61(8):925-7. Krystal AD, Davidson JR. PMID: 17397667.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    183. Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. J Clin Sleep Med. 2007 Feb 15; 3(1):48-55. Krystal A, Fava M, Rubens R, Wessel T, Caron J, Wilson P, Roth T, McCall WV. PMID: 17557453.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    184. Treating the health, quality of life, and functional impairments in insomnia. J Clin Sleep Med. 2007 Feb 15; 3(1):63-72. Krystal AD. PMID: 17557457.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    185. A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder. J Clin Psychiatry. 2007 Feb; 68(2):254-60. Carney CE, Segal ZV, Edinger JD, Krystal AD. PMID: 17335324.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    186. Sleep and psychiatric disorders: future directions. Psychiatr Clin North Am. 2006 Dec; 29(4):1115-30; abstract xi. Krystal AD. PMID: 17118285.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    187. Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening. J Clin Sleep Med. 2006 Oct 15; 2(4):417-23. Zammit GK, Corser B, Doghramji K, Fry JM, James S, Krystal A, Mangano RM. PMID: 17557470.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    188. A polysomnography study of eszopiclone in elderly patients with insomnia. Curr Med Res Opin. 2006 Sep; 22(9):1633-42. McCall WV, Erman M, Krystal AD, Rosenberg R, Scharf M, Zammit GK, Wessel T. PMID: 16968566.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    189. Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol Psychiatry. 2006 Jun 01; 59(11):1052-60. Fava M, McCall WV, Krystal A, Wessel T, Rubens R, Caron J, Amato D, Roth T. PMID: 16581036.
      View in: PubMed   Mentions: 134     Fields:    Translation:Humans
    190. Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia. J Clin Sleep Med. 2006 Jan 15; 2(1):35-41. Walsh JK, Perlis M, Rosenthal M, Krystal A, Jiang J, Roth T. PMID: 17557435.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    191. Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial. Arch Intern Med. 2005 Nov 28; 165(21):2527-35. Edinger JD, Wohlgemuth WK, Krystal AD, Rice JR. PMID: 16314551.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    192. An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Med. 2005 Nov; 6(6):487-95. Roth T, Walsh JK, Krystal A, Wessel T, Roehrs TA. PMID: 16230048.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    193. A comparison of placebo and no-treatment during a hypnotic clinical trial. Int J Clin Pharmacol Ther. 2005 Aug; 43(8):355-9. Mccall WV, Perlis ML, Tu X, Groman AE, Krystal A, Walsh JK. PMID: 16119510.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    194. The effect of insomnia definitions, terminology, and classifications on clinical practice. J Am Geriatr Soc. 2005 Jul; 53(7 Suppl):S258-63. Krystal AD. PMID: 15982374.
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    195. Hypnotics should be considered for the initial treatment of chronic insomnia. Pro. J Clin Sleep Med. 2005 Apr 15; 1(2):120-4. Wohlgemuth WK, Krystal AD. PMID: 17561623.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    196. The possibility of preventing functional impairment due to sleep loss by pharmacologically enhancing sleep. Sleep. 2005 Jan; 28(1):16-7. Krystal AD. PMID: 15700715.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    197. Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia. J Clin Psychiatry. 2004 Aug; 65(8):1128-37. Perlis ML, McCall WV, Krystal AD, Walsh JK. PMID: 15323600.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCTClinical Trials
    198. Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine. Psychopharmacology (Berl). 2004 Apr; 173(1-2):227-8. Singh J, Zarate CA, Krystal AD. PMID: 14722708.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    199. Panel discussion: changing how we think about insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:44-6. Ancoli-Israel S, Benca RM, Edinger JD, Krystal AD, Mendelson W, Moldofsky H, Petrie J, Roth T, Walsh JK, Winkelman J, Special Issues Board Panel Members. PMID: 15153067.
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    200. Introduction: Definitions, measurements, and management in insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:5-7. Krystal AD, Roth T. PMID: 15153061.
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    201. Depression and insomnia in women. Clin Cornerstone. 2004; 6 Suppl 1B:S19-28. Krystal AD. PMID: 15457812.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    202. The changing perspective on chronic insomnia management. J Clin Psychiatry. 2004; 65 Suppl 8:20-5. Krystal AD. PMID: 15153064.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    203. Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep. 2003 Nov 01; 26(7):793-9. Krystal AD, Walsh JK, Laska E, Caron J, Amato DA, Wessel TC, Roth T. PMID: 14655910.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCTClinical Trials
    204. Subtyping primary insomnia: is sleep state misperception a distinct clinical entity? Sleep Med Rev. 2003 Jun; 7(3):203-14. Edinger JD, Krystal AD. PMID: 12927120.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    205. Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci. 2003; 15(1):27-34. Krystal AD, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA, Falcone G, Coffey CE. PMID: 12556568.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    206. Insomnia in women. Clin Cornerstone. 2003; 5(3):41-50. Krystal AD. PMID: 14626540.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    207. NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep. 2002 Sep 15; 25(6):630-40. Krystal AD, Edinger JD, Wohlgemuth WK, Marsh GR. PMID: 12224842.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCTClinical Trials
    208. The use of valerian in neuropsychiatry. CNS Spectr. 2001 Oct; 6(10):841-7. Krystal AD, Ressler I. PMID: 15334039.
      View in: PubMed   Mentions: 2     Fields:    
    209. The development and retrospective testing of an electroencephalographic seizure quality-based stimulus dosing paradigm with ECT. J ECT. 2000 Dec; 16(4):338-49. Krystal AD, Weiner RD, Lindahl V, Massie R. PMID: 11314871.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    210. Prediction of the utility of a switch from unilateral to bilateral ECT in the elderly using treatment 2 ictal EEG indices. J ECT. 2000 Dec; 16(4):327-37. Krystal AD, Holsinger T, Weiner RD, Coffey CE. PMID: 11314870.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    211. ECT stimulus intensity: are present ECT devices too limited? Am J Psychiatry. 2000 Jun; 157(6):963-7. Krystal AD, Dean MD, Weiner RD, Tramontozzi LA, Connor KM, Lindahl VH, Massie RW. PMID: 10831477.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    212. Stationarity and redundancy of multichannel EEG data recorded during generalized tonic-clonic seizures. Brain Topogr. 2000; 12(3):187-200. Zoldi SM, Krystal A, Greenside HS. PMID: 10791682.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    213. EEG effects of ECT: implications for rTMS. Depress Anxiety. 2000; 12(3):157-65. Krystal AD, West M, Prado R, Greenside H, Zoldi S, Weiner RD. PMID: 11126190.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    214. New methods of time series analysis of non-stationary EEG data: eigenstructure decompositions of time varying autoregressions. Clin Neurophysiol. 1999 Dec; 110(12):2197-206. Krystal AD, Prado R, West M. PMID: 10616127.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    215. Zolpidem for persistent insomnia in SSRI-treated depressed patients. J Clin Psychiatry. 1999 Oct; 60(10):668-76. Asnis GM, Chakraburtty A, DuBoff EA, Krystal A, Londborg PD, Rosenberg R, Roth-Schechter B, Scharf MB, Walsh JK. PMID: 10549683.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCTClinical Trials
    216. EEG correlates of the response to ECT: a possible antidepressant role of brain-derived neurotrophic factor. J ECT. 1999 Mar; 15(1):27-38. Krystal AD, Weiner RD. PMID: 10189617.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    217. Sleep in peri-menopausal and post-menopausal women. Sleep Med Rev. 1998 Nov; 2(4):243-53. Krystal AD, Edinger J, Wohlgemuth W, Marsh GR. PMID: 15310495.
      View in: PubMed   Mentions: 34     Fields:    
    218. The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient. J ECT. 1998 Mar; 14(1):5-14. Krystal AD, Watts BV, Weiner RD, Moore S, Steffens DC, Lindahl V. PMID: 9661088.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    219. Low-dimensional chaos in bipolar disorder? Arch Gen Psychiatry. 1998 Mar; 55(3):275-6. Krystal AD, Greenside HS. PMID: 9510223.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    220. Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings. J Neuropsychiatry Clin Neurosci. 1998; 10(2):178-86. Krystal AD, Coffey CE, Weiner RD, Holsinger T. PMID: 9608406.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    221. The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy. Electroencephalogr Clin Neurophysiol. 1997 Dec; 103(6):599-606. Krystal AD, Zaidman C, Greenside HS, Weiner RD, Coffey CE. PMID: 9546486.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    222. Implementing a hospital-wide pain management strategy. Can J Nurs Adm. 1997 Sep; 10(3):74-89. Krystal A, Carr J, Gavaghan K, Porterfield P, Turner L. PMID: 9355286.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    223. Neuropsychiatric considerations in the use of electroconvulsive therapy. J Neuropsychiatry Clin Neurosci. 1997; 9(2):283-92. Krystal AD, Coffey CE. PMID: 9144111.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    224. A comparison of EEG signal dynamics in waking, after anesthesia induction and during electroconvulsive therapy seizures. Electroencephalogr Clin Neurophysiol. 1996 Aug; 99(2):129-40. Krystal AD, Greenside HS, Weiner RD, Gassert D. PMID: 8761049.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    225. The empirical identification of insomnia subtypes: a cluster analytic approach. Sleep. 1996 Jun; 19(5):398-411. Edinger JD, Fins AI, Goeke JM, McMillan DK, Gersh TL, Krystal AD, McCall WV. PMID: 8843531.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    226. Effect of ECT treatment number on the ictal EEG. Psychiatry Res. 1996 May 17; 62(2):179-89. Krystal AD, Weiner RD, Coffey CE, McCall WV. PMID: 8771615.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    227. The relative ability of three ictal EEG frequency bands to differentiate ECT seizures on the basis of electrode placement, stimulus intensity, and therapeutic response. Convuls Ther. 1996 Mar; 12(1):13-24. Krystal AD, Weiner RD, Gassert D, McCall WV, Coffey CE, Sibert T, Holsinger T. PMID: 8777648.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    228. Cost effectiveness of maintenance ECT. Convuls Ther. 1995 Dec; 11(4):283-4. Steffens DC, Krystal AD, Sibert TE, Moore SD, Weiner RD. PMID: 8919583.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    229. ECT seizure duration: reliability of manual and computer-automated determinations. Convuls Ther. 1995 Sep; 11(3):158-69. Krystal AD, Weiner RD. PMID: 8528657.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    230. Seizure threshold in electroconvulsive therapy (ECT) II. The anticonvulsant effect of ECT. Biol Psychiatry. 1995 Jun 01; 37(11):777-88. Coffey CE, Lucke J, Weiner RD, Krystal AD, Aque M. PMID: 7647162.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    231. Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold. Biol Psychiatry. 1995 May 15; 37(10):713-20. Coffey CE, Lucke J, Weiner RD, Krystal AD, Aque M. PMID: 7640326.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    232. The ictal EEG as a marker of adequate stimulus intensity with unilateral ECT. J Neuropsychiatry Clin Neurosci. 1995; 7(3):295-303. Krystal AD, Weiner RD, Coffey CE. PMID: 7580187.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    233. ECT seizure therapeutic adequacy. Convuls Ther. 1994 Jun; 10(2):153-64. Krystal AD, Weiner RD. PMID: 8069641.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    234. The present use of electroconvulsive therapy. Annu Rev Med. 1994; 45:273-81. Weiner RD, Krystal AD. PMID: 8198383.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    235. The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study. Biol Psychiatry. 1993 Dec 01; 34(11):759-67. Krystal AD, Weiner RD, McCall WV, Shelp FE, Arias R, Smith P. PMID: 8292679.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    236. Low-Frequency Ictal EEG Activity and ECT Therapeutic Impact. Convuls Ther. 1993; 9(3):220-224. Krystal AD, Weiner RD. PMID: 11941217.
      View in: PubMed   Mentions: 1     Fields:    
    237. EEG evidence of more "intense" seizure activity with bilateral ECT. Biol Psychiatry. 1992 Mar 15; 31(6):617-21. Krystal AD, Weiner RD, Coffey CE, Smith P, Arias R, Moffett E. PMID: 1581442.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    238. Ambulatory polysomnography: technical aspects and normative values. J Clin Neurophysiol. 1992 Jan; 9(1):68-77. McCall WV, Erwin CW, Edinger JD, Krystal AD, Marsh GR. PMID: 1552010.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    239. The electrophysiology of ECT: relevance to mechanism of action. Clin Neuropharmacol. 1992; 15 Suppl 1 Pt A:671A-672A. Weiner RD, Krystal AD, Coffey CE, Smith P. PMID: 1498995.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    240. The monitoring and management of electrically induced seizures. Psychiatr Clin North Am. 1991 Dec; 14(4):845-69. Weiner RD, Coffey CE, Krystal AD. PMID: 1771151.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    241. Shared features of neuroleptic malignant syndrome and alcohol abuse complications. J Clin Psychiatry. 1990 Dec; 51(12):523. Krystal AD, McEvoy JP. PMID: 2258367.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    242. Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder. J Neuropsychiatry Clin Neurosci. 1990; 2(1):34-43. Krystal A, Krishnan KR, Raitiere M, Poland R, Ritchie JC, Dunnick NR, Hanada K, Nemeroff CB. PMID: 1967010.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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