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Leo Sugrue, MD, PhD

Title(s)Assistant Professor, Radiology
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-353-9467
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    Collapse Biography 
    Collapse Awards and Honors
    UCSF2019Haile T. Debas Academy of Medical Educators Excellence in Teaching Award
    ARRS/ASNR2016ARRS/ASNR Research Scholar Award: Imaging Biomarkers of Obsessive Compulsive Disorder
    Association of University Radiologists2011Siemens AUR Radiology Resident Academic Development (SARRAD) Program

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    Collapse Overview
    Dr. Leo Sugrue is a neuroradiologist who cares for adults and children with conditions affecting the brain and spine; these range from brain tumors and epilepsy to stroke and dementia. Dr. Sugrue has a particular interest in medical imaging of the brain circuits responsible for complex thought and behavior, which are affected in a variety of mental illnesses, including addiction, depression, obsessive-compulsive disorder and mental health conditions related to chronic pain. Dr. Sugrue works closely with colleagues in psychiatry, neurology and neurosurgery to develop new brain circuit–based approaches to diagnosing and treating these conditions.

    Dr. Sugrue has a joint appointment in the Department of Psychiatry and directs the Laboratory for Precision Neuroimaging at UCSF, which focuses on integrating brain imaging with genetic, health and behavioral data to better understand, diagnose and treat brain disease. The lab operates from the perspective that brain disorders have different underlying causes in different people, with a goal of developing ways to identify these subgroups and target trials and treatments to individual illness.

    Dr. Sugrue earned his medical degree at Johns Hopkins School of Medicine and his doctorate in neuroscience at Stanford University. During his graduate and postdoctoral training, he used diverse neuroscience techniques and model systems to explore the neural basis of cognition. He completed a residency in diagnostic radiology and a fellowship in Neuroradiology at UCSF.

    Expertise:
    Neuroradiology

    Specialty:
    Neuroradiology, Cognitive and Systems Neuroscience, Multimodal brain imaging, Neuromodulation

    Professional Interests:
    Imaging of neuropsychiatric disease, imaging genetics, systems-computational-cognitive neuroscience, neural basis of decision making and the influence of reward and valuation on choice behavior, brain-machine interface technologies. Functional MRI (fMRI), electrocorticography (ECOG), magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), brain MR guided focused-ultrasound (MRg-FUS), functional connectivity MRI (fcMRI).

    Education and Training:
    • Medical School: The Johns Hopkins University School of Medicine, Baltimore, MD – Medicine
    • Doctor of Philosophy: Stanford University School of Medicine, CA – Neuroscience
    • Internship: Stanford Hospital and Clinics, CA – Internal Medicine
    • Post-Doctoral Fellowship: Howard Hughes Institute at Stanford University, CA – Neuroscience
    • Residency: University of California, San Francisco – Diagnostic Radiology
    • Fellowship University of California, San Francisco – ACGME Neuroradiology
    • California Medical License
    • American Board of Radiology Certificate in Diagnostic Radiology
    • American Board of Radiology Subspecialty Certificate in Neuroradiology

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuroradiological Features of Mild and Severe SARS-CoV-2 Infection. Acad Radiol. 2020 11; 27(11):1507-1514. Pan S, Chen WC, Baal JD, Sugrue LP. PMID: 32912668.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    2. Gray Matter Changes in Adolescents Participating in a Meditation Training. Front Hum Neurosci. 2020; 14:319. Yuan JP, Connolly CG, Henje E, Sugrue LP, Yang TT, Xu D, Tymofiyeva O. PMID: 32922278.
      View in: PubMed   Mentions:
    3. Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci. Biol Psychiatry. 2021 Feb 01; 89(3):227-235. Smeland OB, Shadrin A, Bahrami S, Broce I, Tesli M, Frei O, Wirgenes KV, O'Connell KS, Krull F, Bettella F, Steen NE, Sugrue L, Wang Y, Svenningsson P, Sharma M, Pihlstrøm L, Toft M, O'Donovan M, Djurovic S, Desikan R, Dale AM, Andreassen OA. PMID: 32201043.
      View in: PubMed   Mentions:    Fields:    
    4. Predictive Value of Noncontrast Head CT with Negative Findings in the Emergency Department Setting. AJNR Am J Neuroradiol. 2020 02; 41(2):213-218. Callen AL, Chow DS, Chen YA, Richelle HR, Pao J, Bardis M, Weinberg BD, Hess CP, Sugrue LP. PMID: 31974080.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Multi-Disease Segmentation of Gliomas and White Matter Hyperintensities in the BraTS Data Using a 3D Convolutional Neural Network. Front Comput Neurosci. 2019; 13:84. Rudie JD, Weiss DA, Saluja R, Rauschecker AM, Wang J, Sugrue L, Bakas S, Colby JB. PMID: 31920609.
      View in: PubMed   Mentions:
    6. The Radiogenomics of Late-onset Alzheimer Disease. Top Magn Reson Imaging. 2019 Dec; 28(6):325-334. Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS. PMID: 31794505.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Image processing and analysis methods for the Adolescent Brain Cognitive Development Study. Neuroimage. 2019 11 15; 202:116091. Hagler DJ, Hatton S, Cornejo MD, Makowski C, Fair DA, Dick AS, Sutherland MT, Casey BJ, Barch DM, Harms MP, Watts R, Bjork JM, Garavan HP, Hilmer L, Pung CJ, Sicat CS, Kuperman J, Bartsch H, Xue F, Heitzeg MM, Laird AR, Trinh TT, Gonzalez R, Tapert SF, Riedel MC, Squeglia LM, Hyde LW, Rosenberg MD, Earl EA, Howlett KD, Baker FC, Soules M, Diaz J, de Leon OR, Thompson WK, Neale MC, Herting M, Sowell ER, Alvarez RP, Hawes SW, Sanchez M, Bodurka J, Breslin FJ, Morris AS, Paulus MP, Simmons WK, Polimeni JR, van der Kouwe A, Nencka AS, Gray KM, Pierpaoli C, Matochik JA, Noronha A, Aklin WM, Conway K, Glantz M, Hoffman E, Little R, Lopez M, Pariyadath V, Weiss SR, Wolff-Hughes DL, DelCarmen-Wiggins R, Feldstein Ewing SW, Miranda-Dominguez O, Nagel BJ, Perrone AJ, Sturgeon DT, Goldstone A, Pfefferbaum A, Pohl KM, Prouty D, Uban K, Bookheimer SY, Dapretto M, Galvan A, Bagot K, Giedd J, Infante MA, Jacobus J, Patrick K, Shilling PD, Desikan R, Li Y, Sugrue L, Banich MT, Friedman N, Hewitt JK, Hopfer C, Sakai J, Tanabe J, Cottler LB, Nixon SJ, Chang L, Cloak C, Ernst T, Reeves G, Kennedy DN, Heeringa S, Peltier S, Schulenberg J, Sripada C, Zucker RA, Iacono WG, Luciana M, Calabro FJ, Clark DB, Lewis DA, Luna B, Schirda C, Brima T, Foxe JJ, Freedman EG, Mruzek DW, Mason MJ, Huber R, McGlade E, Prescot A, Renshaw PF, Yurgelun-Todd DA, Allgaier NA, Dumas JA, Ivanova M, Potter A, Florsheim P, Larson C, Lisdahl K, Charness ME, Fuemmeler B, Hettema JM, Maes HH, Steinberg J, Anokhin AP, Glaser P, Heath AC, Madden PA, Baskin-Sommers A, Constable RT, Grant SJ, Dowling GJ, Brown SA, Jernigan TL, Dale AM. PMID: 31415884.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    8. Precision neuroradiology: mapping the nodes and networks that link genes to behaviour. Br J Radiol. 2019 Sep; 92(1101):20190093. Sugrue LP, Desikan RS. PMID: 31294609.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. What Are Polygenic Scores and Why Are They Important? JAMA. 2019 May 14; 321(18):1820-1821. Sugrue LP, Desikan RS. PMID: 30958510.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    10. Efficacy of Mindfulness-Based Cognitive Training in Surgery: Additional Analysis of the Mindful Surgeon Pilot Randomized Clinical Trial. JAMA Netw Open. 2019 05 03; 2(5):e194108. Lebares CC, Guvva EV, Olaru M, Sugrue LP, Staffaroni AM, Delucchi KL, Kramer JH, Ascher NL, Harris HW. PMID: 31125095.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Deviation from the matching law reflects an optimal strategy involving learning over multiple timescales. Nat Commun. 2019 04 01; 10(1):1466. Iigaya K, Ahmadian Y, Sugrue LP, Corrado GS, Loewenstein Y, Newsome WT, Fusi S. PMID: 30931937.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain. 2019 02 01; 142(2):460-470. Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS. PMID: 30689776.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. PMID: 30413934.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Sci Rep. 2018 09 06; 8(1):13373. Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, Andreassen OA, Jernigan T, Dale A, Barkovich AJ, Desikan RS, Sugrue LP. PMID: 30190613.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Abnormal Morphology of Select Cortical and Subcortical Regions in Neurofibromatosis Type 1. Radiology. 2018 11; 289(2):499-508. Barkovich MJ, Tan CH, Nillo RM, Li Y, Xu D, Glastonbury CM, Glenn OA, Dillon WP, Hess CP, Mueller S, Kline C, Dale AM, Jernigan TL, Sugrue LP, Barkovich AJ, Desikan RS. PMID: 30179114.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Hybrid 3D/2D Convolutional Neural Network for Hemorrhage Evaluation on Head CT. AJNR Am J Neuroradiol. 2018 09; 39(9):1609-1616. Chang PD, Kuoy E, Grinband J, Weinberg BD, Thompson M, Homo R, Chen J, Abcede H, Shafie M, Sugrue L, Filippi CG, Su MY, Yu W, Hess C, Chow D. PMID: 30049723.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    17. CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry. 2018 04 11; 8(1):73. Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS. PMID: 29636460.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Laser ablative therapy of sessile hypothalamic hamartomas in children using interventional MRI: report of 5 cases. J Neurosurg Pediatr. 2018 05; 21(5):460-465. Southwell DG, Birk HS, Larson PS, Starr PA, Sugrue LP, Auguste KI. PMID: 29451455.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med. 2018 01; 15(1):e1002504. Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL, Andreassen OA, Dale AM, Desikan RS, Sugrue LP. PMID: 29377952.
      View in: PubMed   Mentions: 1     Fields:    
    20. Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med. 2018 01; 15(1):e1002487. Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J, Momeni P, Hess CP, Dillon WP, Miller ZA, Bonham LW, Rabinovici GD, Rosen HJ, Schellenberg GD, Franke A, Karlsen TH, Veldink JH, Ferrari R, Yokoyama JS, Miller BL, Andreassen OA, Dale AM, Desikan RS, Sugrue LP. PMID: 29315334.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    21. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol. 2018 01; 135(1):85-93. Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS. PMID: 29177679.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. Understanding the Neurophysiology and Quantification of Brain Perfusion. Top Magn Reson Imaging. 2017 Apr; 26(2):57-65. Tong E, Sugrue L, Wintermark M. PMID: 28277465.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathol. 2017 05; 133(5):825-837. Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J, Momeni P, Sugrue LP, Hess CP, James Barkovich A, Boxer AL, Seeley WW, Rabinovici GD, Rosen HJ, Miller BL, Schmansky NJ, Fischl B, Hyman BT, Dickson DW, Schellenberg GD, Andreassen OA, Dale AM, Desikan RS. PMID: 28271184.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    24. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry. 2017 02; 88(2):152-164. Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS. PMID: 27899424.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    25. Heterogeneous 18F-FDG uptake in recurrent respiratory papillomatosis. Clin Nucl Med. 2013 May; 38(5):387-9. Yu JP, Barajas RF, Olorunsola D, Sugrue LP, Hernandez-Pampaloni M. PMID: 23486321.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Stimulus onset quenches neural variability: a widespread cortical phenomenon. Nat Neurosci. 2010 Mar; 13(3):369-78. Churchland MM, Yu BM, Cunningham JP, Sugrue LP, Cohen MR, Corrado GS, Newsome WT, Clark AM, Hosseini P, Scott BB, Bradley DC, Smith MA, Kohn A, Movshon JA, Armstrong KM, Moore T, Chang SW, Snyder LH, Lisberger SG, Priebe NJ, Finn IM, Ferster D, Ryu SI, Santhanam G, Sahani M, Shenoy KV. PMID: 20173745.
      View in: PubMed   Mentions: 314     Fields:    Translation:AnimalsCells
    27. Linear-Nonlinear-Poisson models of primate choice dynamics. J Exp Anal Behav. 2005 Nov; 84(3):581-617. Corrado GS, Sugrue LP, Seung HS, Newsome WT. PMID: 16596981.
      View in: PubMed   Mentions: 64     Fields:    Translation:Animals
    28. Choosing the greater of two goods: neural currencies for valuation and decision making. Nat Rev Neurosci. 2005 May; 6(5):363-75. Sugrue LP, Corrado GS, Newsome WT. PMID: 15832198.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimals
    29. Matching behavior and the representation of value in the parietal cortex. Science. 2004 Jun 18; 304(5678):1782-7. Sugrue LP, Corrado GS, Newsome WT. PMID: 15205529.
      View in: PubMed   Mentions: 354     Fields:    Translation:AnimalsCells
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