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Leo Sugrue, MD, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentRadiology
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-353-9467
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    Collapse Biography 
    Collapse Awards and Honors
    Association of University Radiologists2011Siemens AUR Radiology Resident Academic Development (SARRAD) Program

    Collapse Overview 
    Collapse Overview
    Dr. Sugrue is an Assistant Professor in Residence and Attending Neuroradiologist in the Neuroradiology section of the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Together with Dr. Rahul Desikan, Dr. Sugrue co-directs the Laboratory for Precision Neuroimaging at UCSF.

    As a neuroscientist and clinical neuroradiologist, Dr. Sugrue’s goal is to develop new tools for imaging, measuring, and modifying brain activity, and to translate these tools from the lab to the clinic where they can improve the prediction, diagnosis, and treatment of brain disease. Dr. Sugrue and his team work on a range of research projects that share the common theme of combining different types of data to better understand the underlying cause of brain disease in individual patients.

    These include projects aimed at understanding how the balance of activity across networks of brain areas may contribute to conditions such as obsessive compulsive disorder (OCD) and Huntington’s disease (HD), as well as projects that combine brain imaging with genetic, physiologic, and behavioral markers to better understand neurodegenerative and neurodevelopmental disorders. In an example of this approach, his team’s recent work on frontotemporal dementia (FTD) combined genome-wide association studies with gene expression data to demonstrate a link between certain subtypes of FTD and immune dysfunction. Moving forward the team hopes build on this work by developing methods to directly image neuroinflammation in the brain as a biomarker of disease risk and progression in FTD and other neurodegenerative diseases including ALS.

    Expertise:
    Neuroradiology

    Specialty:
    Neuroradiology, Cognitive and Systems Neuroscience, Multimodal brain imaging

    Professional Interests:
    Imaging of neuropsychiatric disease, imaging genetics, systems-computational-cognitive neuroscience, neural basis of decision making and the influence of reward and valuation on choice behavior, brain-machine interface technologies. Functional MRI (fMRI), electrocorticography (ECOG), magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), brain MR guided focused-ultrasound (MRg-FUS), functional connectivity MRI (fcMRI).

    Education and Training:
    • Medical School: The Johns Hopkins University School of Medicine, Baltimore, MD – Medicine
    • Doctor of Philosophy: Stanford University School of Medicine, CA – Neuroscience
    • Internship: Stanford Hospital and Clinics, CA – Internal Medicine
    • Post-Doctoral Fellowship: Howard Hughes Institute at Stanford University, CA – Neuroscience
    • Residency: University of California, San Francisco – Diagnostic Radiology
    • Fellowship: University of California, San Francisco – Diagnostic Neuroradiology
    • Fellowship University of California, San Francisco – ACGME Neuroradiology
    • California Medical License
    • American Board of Radiology Certificate in Diagnostic Radiology


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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2018 Nov 09. PMID: 30413934.
      View in: PubMed
    2. Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, Andreassen OA, Jernigan T, Dale A, Barkovich AJ, Desikan RS, Sugrue LP. Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Sci Rep. 2018 Sep 06; 8(1):13373. PMID: 30190613.
      View in: PubMed
    3. Barkovich MJ, Tan CH, Nillo RM, Li Y, Xu D, Glastonbury CM, Glenn OA, Dillon WP, Hess CP, Mueller S, Kline C, Dale AM, Jernigan TL, Sugrue LP, Barkovich AJ, Desikan RS. Abnormal Morphology of Select Cortical and Subcortical Regions in Neurofibromatosis Type 1. Radiology. 2018 Sep 04; 172863. PMID: 30179114.
      View in: PubMed
    4. Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS. CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry. 2018 Apr 11; 8(1):73. PMID: 29636460.
      View in: PubMed
    5. Southwell DG, Birk HS, Larson PS, Starr PA, Sugrue LP, Auguste KI. Laser ablative therapy of sessile hypothalamic hamartomas in children using interventional MRI: report of 5 cases. J Neurosurg Pediatr. 2018 Feb 16; 1-6. PMID: 29451455.
      View in: PubMed
    6. Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J. Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med. 2018 Jan; 15(1):e1002504. PMID: 29377952.
      View in: PubMed
    7. Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J. Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. PLoS Med. 2018 01; 15(1):e1002487. PMID: 29315334.
      View in: PubMed
    8. Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol. 2018 Jan; 135(1):85-93. PMID: 29177679.
      View in: PubMed
    9. Tong E, Sugrue L, Wintermark M. Understanding the Neurophysiology and Quantification of Brain Perfusion. Top Magn Reson Imaging. 2017 Apr; 26(2):57-65. PMID: 28277465.
      View in: PubMed
    10. Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathol. 2017 May; 133(5):825-837. PMID: 28271184.
      View in: PubMed
    11. Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry. 2017 02; 88(2):152-164. PMID: 27899424.
      View in: PubMed
    12. Yu JP, Barajas RF, Olorunsola D, Sugrue LP, Hernandez-Pampaloni M. Heterogeneous 18F-FDG uptake in recurrent respiratory papillomatosis. Clin Nucl Med. 2013 May; 38(5):387-9. PMID: 23486321.
      View in: PubMed
    13. Churchland MM, Yu BM, Cunningham JP, Sugrue LP, Cohen MR, Corrado GS, Newsome WT, Clark AM, Hosseini P, Scott BB, Bradley DC, Smith MA, Kohn A, Movshon JA, Armstrong KM, Moore T, Chang SW, Snyder LH, Lisberger SG, Priebe NJ, Finn IM, Ferster D, Ryu SI, Santhanam G, Sahani M, Shenoy KV. Stimulus onset quenches neural variability: a widespread cortical phenomenon. Nat Neurosci. 2010 Mar; 13(3):369-78. PMID: 20173745; PMCID: PMC2828350.
    14. Corrado GS, Sugrue LP, Seung HS, Newsome WT. Linear-Nonlinear-Poisson models of primate choice dynamics. J Exp Anal Behav. 2005 Nov; 84(3):581-617. PMID: 16596981; PMCID: PMC1389782.
    15. Sugrue LP, Corrado GS, Newsome WT. Choosing the greater of two goods: neural currencies for valuation and decision making. Nat Rev Neurosci. 2005 May; 6(5):363-75. PMID: 15832198.
      View in: PubMed
    16. Sugrue LP, Corrado GS, Newsome WT. Matching behavior and the representation of value in the parietal cortex. Science. 2004 Jun 18; 304(5678):1782-7. PMID: 15205529.
      View in: PubMed