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Lilly Bourguignon, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
AddressVAMC
San Francisco CA 94121
Phone415-221-4810 ext. 3321
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    Collapse Research 
    Collapse Research Activities and Funding
    Selective Hyaluronan Treatment to Overcome Age-related Epidermal Dysfunction
    VA I01RX000601Apr 1, 2013 - Mar 31, 2017
    Role: Principal Investigator
    CD44 &Stem Cell Marker (Nanog) in Head and Neck Cancer
    VA I01BX000628Oct 1, 2010 - Sep 30, 2014
    Role: Principal Investigator
    CD44-p185HER2 Interaction in Ovarian Cancer Progression
    NIH/NCI R01CA078633Apr 1, 1999 - Jan 31, 2010
    Role: Principal Investigator
    CD44/Variant Cytoskeleton in Breast Cancer Progression
    NIH/NCI R01CA066163Apr 1, 1995 - May 31, 2014
    Role: Principal Investigator
    BIOCHEMICAL &CYTOCHEMICAL STUDIES ON LYMPHOID MEMBRANE
    NIH/NIGMS R01GM036353Jan 1, 1982 - Jun 30, 1996
    Role: Principal Investigator
    BIOCHEMICAL AND IMMUNOCYTOCHEMICAL LYMPHOCYTE STUDIES
    NIH/NIAID R01AI019188Jan 1, 1982 - Dec 31, 1986
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bourguignon L, Earle C, Shiina M. Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells. Int J Mol Sci. 2017 Aug 24; 18(9). PMID: 28837080.
      View in: PubMed
    2. Bourguignon L. Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression. Int J Mol Sci. 2016 Apr 07; 17(4):517. PMID: 27070574; PMCID: PMC4848973.
    3. Bourguignon L, Wong G, Shiina M. Up-regulation of Histone Methyltransferase, DOT1L, by Matrix Hyaluronan Promotes MicroRNA-10 Expression Leading to Tumor Cell Invasion and Chemoresistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma. J Biol Chem. 2016 May 13; 291(20):10571-85. PMID: 27002147; PMCID: PMC4865907 [Available on 05/13/17].
    4. Shiina M, Bourguignon L. Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer. Int J Cell Biol. 2015; 2015:989070. PMID: 26448762; PMCID: PMC4581563.
    5. Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon L, Ihnat MA. Identification of novel drugs to target dormant micrometastases. BMC Cancer. 2015 May 14; 15:404. PMID: 25971923; PMCID: PMC4434572.
    6. Bourguignon L, Bikle D. Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation. Front Immunol. 2015; 6:224. PMID: 26029210; PMCID: PMC4429634.
    7. Braet Y, Bourguignon L, Vanpoucke S, Drome V, Hubrecht F. New developmental data for Cynomya mortuorum (L., 1761) in Belgium (Diptera: Calliphoridae). Forensic Sci Int. 2015 Jul; 252:29-32. PMID: 25933426.
      View in: PubMed
    8. Bourguignon L. Matrix hyaluronan-activated CD44 signaling promotes keratinocyte activities and improves abnormal epidermal functions. Am J Pathol. 2014 Jul; 184(7):1912-9. PMID: 24819962; PMCID: PMC4076472.
    9. Chen L, Bourguignon L. Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells. Mol Cancer. 2014 Mar 08; 13:52. PMID: 24606718; PMCID: PMC3975292.
    10. Chan JK, Blansit K, Kiet T, Sherman A, Wong G, Earle C, Bourguignon L. The inhibition of miR-21 promotes apoptosis and chemosensitivity in ovarian cancer. Gynecol Oncol. 2014 Mar; 132(3):739-44. PMID: 24472409.
      View in: PubMed
    11. Bourguignon L, Shiina M, Li JJ. Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression. Adv Cancer Res. 2014; 123:255-75. PMID: 25081533.
      View in: PubMed
    12. Bourguignon L, Wong G, Xia W, Man MQ, Holleran WM, Elias PM. Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. J Dermatol Sci. 2013 Oct; 72(1):32-44. PMID: 23790635; PMCID: PMC3775883.
    13. Bourguignon L, Wong G, Earle C, Chen L. Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma. J Biol Chem. 2012 Sep 21; 287(39):32800-24. PMID: 22847005; PMCID: PMC3463333.
    14. Wang SJ, Earle C, Wong G, Bourguignon L. Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression. Head Neck. 2013 Apr; 35(4):511-20. PMID: 22473523.
      View in: PubMed
    15. Bourguignon L. Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression. Small GTPases. 2012 Jan-Mar; 3(1):53-9. PMID: 22714418; PMCID: PMC3398919.
    16. Bourguignon L, Wong G, Earle CA, Xia W. Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NF?B signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion. Cytoskeleton (Hoboken). 2011 Dec; 68(12):671-93. PMID: 22031535; PMCID: PMC3240717.
    17. Bourguignon L, Earle C, Wong G, Spevak CC, Krueger K. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene. 2012 Jan 12; 31(2):149-60. PMID: 21685938; PMCID: PMC3179812.
    18. Wang SJ, Bourguignon L. Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance. Am J Pathol. 2011 Mar; 178(3):956-63. PMID: 21356346; PMCID: PMC3069910.
    19. Bourguignon L, Wong G, Earle C, Krueger K, Spevak CC. Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion. J Biol Chem. 2010 Nov 19; 285(47):36721-35. PMID: 20843787; PMCID: PMC2978601.
    20. Torre C, Wang SJ, Xia W, Bourguignon L. Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling. Arch Otolaryngol Head Neck Surg. 2010 May; 136(5):493-501. PMID: 20479382; PMCID: PMC2874205.
    21. Wang SJ, Wong G, de Heer AM, Xia W, Bourguignon L. CD44 variant isoforms in head and neck squamous cell carcinoma progression. Laryngoscope. 2009 Aug; 119(8):1518-30. PMID: 19507218; PMCID: PMC2718060.
    22. Bourguignon L, Spevak CC, Wong G, Xia W, Gilad E. Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem. 2009 Sep 25; 284(39):26533-46. PMID: 19633292; PMCID: PMC2785342.
    23. Dekeirsschieter J, Verheggen FJ, Gohy M, Hubrecht F, Bourguignon L, Lognay G, Haubruge E. Cadaveric volatile organic compounds released by decaying pig carcasses (Sus domesticus L.) in different biotopes. Forensic Sci Int. 2009 Aug 10; 189(1-3):46-53. PMID: 19423246.
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    24. Man M, Elias PM, Man W, Wu Y, Bourguignon L, Feingold KR, Man MQ. The role of CD44 in cutaneous inflammation. Exp Dermatol. 2009 Nov; 18(11):962-8. PMID: 19469887; PMCID: PMC2784008.
    25. Hsu JY, Bourguignon L, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci. 2008 Dec 10; 28(50):13467-77. PMID: 19074020; PMCID: PMC2712293.
    26. Bourguignon L, Xia W, Wong G. Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. J Biol Chem. 2009 Jan 30; 284(5):2657-71. PMID: 19047049; PMCID: PMC2631959.
    27. Bourguignon L, Peyrollier K, Xia W, Gilad E. Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem. 2008 Jun 20; 283(25):17635-51. PMID: 18441325; PMCID: PMC2427357.
    28. Bourguignon L. Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Semin Cancer Biol. 2008 Aug; 18(4):251-9. PMID: 18450475; PMCID: PMC2505114.
    29. Wang SJ, Wreesmann VB, Bourguignon L. Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer. Head Neck. 2007 Jun; 29(6):550-8. PMID: 17252589.
      View in: PubMed
    30. Bourguignon L, Gilad E, Peyrollier K. Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration. J Biol Chem. 2007 Jul 06; 282(27):19426-41. PMID: 17493932.
      View in: PubMed
    31. Bourguignon L, Gilad E, Peyrollier K, Brightman A, Swanson RA. Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes. J Neurochem. 2007 May; 101(4):1002-17. PMID: 17403031.
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    32. Wang SJ, Peyrollier K, Bourguignon L. The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2007 Mar; 133(3):281-8. PMID: 17372087.
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    33. Bourguignon L, Peyrollier K, Gilad E, Brightman A. Hyaluronan-CD44 interaction with neural Wiskott-Aldrich syndrome protein (N-WASP) promotes actin polymerization and ErbB2 activation leading to beta-catenin nuclear translocation, transcriptional up-regulation, and cell migration in ovarian tumor cells. J Biol Chem. 2007 Jan 12; 282(2):1265-80. PMID: 17092940.
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    34. Wang SJ, Bourguignon L. Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2006 Jul; 132(7):771-8. PMID: 16847188.
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    35. Bourguignon L, Ramez M, Gilad E, Singleton PA, Man MQ, Crumrine DA, Elias PM, Feingold KR. Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis. J Invest Dermatol. 2006 Jun; 126(6):1356-65. PMID: 16557236.
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    36. Bourguignon L, Gilad E, Brightman A, Diedrich F, Singleton P. Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. J Biol Chem. 2006 May 19; 281(20):14026-40. PMID: 16565089.
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    37. Wang SJ, Bourguignon L. Hyaluronan-CD44 promotes phospholipase C-mediated Ca2+ signaling and cisplatin resistance in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2006 Jan; 132(1):19-24. PMID: 16415424.
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    38. Xie Z, Singleton PA, Bourguignon L, Bikle DD. Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1. Mol Biol Cell. 2005 Jul; 16(7):3236-46. PMID: 15872086; PMCID: PMC1165407.
    39. Bourguignon L, Gilad E, Rothman K, Peyrollier K. Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression. J Biol Chem. 2005 Mar 25; 280(12):11961-72. PMID: 15655247.
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    40. Cao JJ, Singleton PA, Majumdar S, Boudignon B, Burghardt A, Kurimoto P, Wronski TJ, Bourguignon L, Halloran BP. Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44. J Bone Miner Res. 2005 Jan; 20(1):30-40. PMID: 15619667.
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    41. Bourguignon L, Singleton PA, Diedrich F. Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation. J Biol Chem. 2004 Jul 09; 279(28):29654-69. PMID: 15123640.
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    42. Bourguignon L, Singleton PA, Diedrich F, Stern R, Gilad E. CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem. 2004 Jun 25; 279(26):26991-7007. PMID: 15090545.
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    43. Singleton PA, Bourguignon L. CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation. Exp Cell Res. 2004 Apr 15; 295(1):102-18. PMID: 15051494.
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    44. Bourguignon L, Singleton PA, Zhu H, Diedrich F. Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. J Biol Chem. 2003 Aug 08; 278(32):29420-34. PMID: 12748184.
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    45. Singleton PA, Bourguignon L. CD44v10 interaction with Rho-kinase (ROK) activates inositol 1,4,5-triphosphate (IP3) receptor-mediated Ca2+ signaling during hyaluronan (HA)-induced endothelial cell migration. Cell Motil Cytoskeleton. 2002 Dec; 53(4):293-316. PMID: 12378540.
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    46. Bourguignon L, Singleton PA, Zhu H, Zhou B. Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem. 2002 Oct 18; 277(42):39703-12. PMID: 12145287.
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    47. Turley EA, Noble PW, Bourguignon L. Signaling properties of hyaluronan receptors. J Biol Chem. 2002 Feb 15; 277(7):4589-92. PMID: 11717317.
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    48. Bourguignon L, Zhu H, Zhou B, Diedrich F, Singleton PA, Hung MC. Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth. J Biol Chem. 2001 Dec 28; 276(52):48679-92. PMID: 11606575.
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    49. Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D. Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation. J Biol Chem. 2001 Nov 23; 276(47):44129-36. PMID: 11535593.
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    50. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol. 2001 Sep; 3(9):802-8. PMID: 11533659.
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    51. Bourguignon L. CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression. J Mammary Gland Biol Neoplasia. 2001 Jul; 6(3):287-97. PMID: 11547898.
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    52. Hunter JR, Brickley MB, Bourgeois J, Bouts W, Bourguignon L, Hubrecht F, De Winne J, Van Haaster H, Hakbijl T, De Jong H, Smits L, Van Wijngaarden LH, Luschen M. Forensic archaeology, forensic anthropology and human rights in Europe. Sci Justice. 2001 Jul-Sep; 41(3):173-8. PMID: 11515163.
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    53. Franzmann EJ, Weed DT, Civantos FJ, Goodwin WJ, Bourguignon L. A novel CD44 v3 isoform is involved in head and neck squamous cell carcinoma progression. Otolaryngol Head Neck Surg. 2001 Apr; 124(4):426-32. PMID: 11283501.
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    54. Gofflot F, Gaoua W, Bourguignon L, Roux C, Picard JJ. Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis. Dev Dyn. 2001 Feb; 220(2):99-111. PMID: 11169843.
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    55. Bourguignon L, Zhu H, Shao L, Chen YW. CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration. J Biol Chem. 2001 Mar 09; 276(10):7327-36. PMID: 11084024.
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    56. Bourguignon L, Zhu H, Shao L, Chen YW. Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration. J Cell Biol. 2000 Jul 10; 150(1):177-91. PMID: 10893266; PMCID: PMC2185563.
    57. Diaz F, Bourguignon L. Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells. Cell Calcium. 2000 Jun; 27(6):315-28. PMID: 11013462.
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    58. Zhu D, Bourguignon L. Interaction between CD44 and the repeat domain of ankyrin promotes hyaluronic acid-mediated ovarian tumor cell migration. J Cell Physiol. 2000 May; 183(2):182-95. PMID: 10737894.
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    59. Bourguignon L, Zhu H, Shao L, Chen YW. CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J Biol Chem. 2000 Jan 21; 275(3):1829-38. PMID: 10636882.
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    60. Kalish ED, Iida N, Moffat FL, Bourguignon L. A new CD44V3-containing isoform is involved in tumor cell growth and migration during human breast carcinoma progression. Front Biosci. 1999 Jan 01; 4:A1-8. PMID: 9872731.
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    61. Bourguignon L, Zhu H, Shao L, Zhu D, Chen YW. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells. Cell Motil Cytoskeleton. 1999; 43(4):269-87. PMID: 10423269.
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    62. Bourguignon L, Zhu D, Zhu H. CD44 isoform-cytoskeleton interaction in oncogenic signaling and tumor progression. Front Biosci. 1998 Jul 01; 3:d637-49. PMID: 9634539.
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    63. Bourguignon L, Gunja-Smith Z, Iida N, Zhu HB, Young LJ, Muller WJ, Cardiff RD. CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells. J Cell Physiol. 1998 Jul; 176(1):206-15. PMID: 9618160.
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    64. Zhu D, Bourguignon L. The ankyrin-binding domain of CD44s is involved in regulating hyaluronic acid-mediated functions and prostate tumor cell transformation. Cell Motil Cytoskeleton. 1998; 39(3):209-22. PMID: 9519902.
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    65. Huang AJ, Li CH, Chen YW, Bourguignon L. Co-expression of bcl-2 and CD44s in basal layers of human ocular surface epithelia. Adv Exp Med Biol. 1998; 438:527-31. PMID: 9634932.
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    66. Bourguignon L, Zhu H, Chu A, Iida N, Zhang L, Hung MC. Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation. J Biol Chem. 1997 Oct 31; 272(44):27913-8. PMID: 9346940.
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    67. Iida N, Bourguignon L. Coexpression of CD44 variant (v10/ex14) and CD44S in human mammary epithelial cells promotes tumorigenesis. J Cell Physiol. 1997 May; 171(2):152-60. PMID: 9130462.
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    68. Lokeshwar VB, Iida N, Bourguignon L. The cell adhesion molecule, GP116, is a new CD44 variant (ex14/v10) involved in hyaluronic acid binding and endothelial cell proliferation. J Biol Chem. 1996 Sep 27; 271(39):23853-64. PMID: 8798616.
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    69. Moffat FL, Han T, Li ZM, Peck MD, Falk RE, Spalding PB, Jy W, Ahn YS, Chu AJ, Bourguignon L. Involvement of CD44 and the cytoskeletal linker protein ankyrin in human neutrophil bacterial phagocytosis. J Cell Physiol. 1996 Sep; 168(3):638-47. PMID: 8816918.
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    70. Peck MD, Li Z, Han T, Wang W, Jy W, Ahn YS, Ziboh VA, Chu AJ, Bourguignon L. Fatty acid unsaturation increases expression and capping of murine lymphocyte CD44 and CD45. Nutrition. 1996 Sep; 12(9):616-22. PMID: 8878171.
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    71. Peck MD, Li Z, Jy W, Chu AJ, Bourguignon L. Association of murine splenocyte CD3 complex to the cytoskeleton: absence of modulation by exogenous fatty acids. Cell Biol Int. 1996 Aug; 20(8):531-7. PMID: 8938986.
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    72. Donnadieu E, Bourguignon L. Ca2+ signaling in endothelial cells stimulated by bradykinin: Ca2+ measurement in the mitochondria and the cytosol by confocal microscopy. Cell Calcium. 1996 Jul; 20(1):53-61. PMID: 8864571.
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    73. Moffat FL, Han T, Li ZM, Peck MD, Jy W, Ahn YS, Chu AJ, Bourguignon L. Supplemental L-arginine HCl augments bacterial phagocytosis in human polymorphonuclear leukocytes. J Cell Physiol. 1996 Jul; 168(1):26-33. PMID: 8647919.
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    74. Zhu D, Bourguignon L. Overexpression of CD44 in pl85(neu)-transfected NIH3T3 cells promotes an up-regulation of hyaluronic acid-mediated membrane-cytoskeleton interaction and cell adhesion. Oncogene. 1996 Jun 06; 12(11):2309-14. PMID: 8649770.
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    75. Welsh CF, Zhu D, Bourguignon L. Interaction of CD44 variant isoforms with hyaluronic acid and the cytoskeleton in human prostate cancer cells. J Cell Physiol. 1995 Sep; 164(3):605-12. PMID: 7544357.
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    76. Bourguignon L, Chu A, Jin H, Brandt NR. Ryanodine receptor-ankyrin interaction regulates internal Ca2+ release in mouse T-lymphoma cells. J Biol Chem. 1995 Jul 28; 270(30):17917-22. PMID: 7629097.
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    77. Bourguignon L, Jin H. Identification of the ankyrin-binding domain of the mouse T-lymphoma cell inositol 1,4,5-trisphosphate (IP3) receptor and its role in the regulation of IP3-mediated internal Ca2+ release. J Biol Chem. 1995 Mar 31; 270(13):7257-60. PMID: 7706265.
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    78. Iida N, Bourguignon L. New CD44 splice variants associated with human breast cancers. J Cell Physiol. 1995 Jan; 162(1):127-33. PMID: 7529235.
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    79. Iida N, Lokeshwar VB, Bourguignon L. Mapping the fodrin binding domain in CD45, a leukocyte membrane-associated tyrosine phosphatase. J Biol Chem. 1994 Nov 18; 269(46):28576-83. PMID: 7961804.
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    80. Lokeshwar VB, Fregien N, Bourguignon L. Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function. J Cell Biol. 1994 Aug; 126(4):1099-109. PMID: 7519619; PMCID: PMC2120123.
    81. Iida N, Bourguignon L. A new splice variant of the inositol-1,4,5-triphosphate (IP3) receptor. Cell Signal. 1994 May; 6(4):449-55. PMID: 7946968.
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    82. Bourguignon LY, Iida N, Sobrin L, Bourguignon L. Identification of an IP3 receptor in endothelial cells. J Cell Physiol. 1994 Apr; 159(1):29-34. PMID: 8138588.
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    83. Bourguignon L, Lokeshwar VB, Chen X, Kerrick WG. Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction. J Immunol. 1993 Dec 15; 151(12):6634-44. PMID: 7505012.
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    84. Bourguignon L, Iida N, Jin H. The involvement of the cytoskeleton in regulating IP3 receptor-mediated internal Ca2+ release in human blood platelets. Cell Biol Int. 1993 Aug; 17(8):751-8. PMID: 8220303.
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    85. Bourguignon L, Jin H, Iida N, Brandt NR, Zhang SH. The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells. J Biol Chem. 1993 Apr 05; 268(10):7290-7. PMID: 8385102.
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    86. Lokeshwar VB, Bourguignon L. The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction. J Biol Chem. 1992 Nov 05; 267(31):22073-8. PMID: 1429559.
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    87. Lokeshwar VB, Bourguignon L. Tyrosine phosphatase activity of lymphoma CD45 (GP180) is regulated by a direct interaction with the cytoskeleton. J Biol Chem. 1992 Oct 25; 267(30):21551-7. PMID: 1400466.
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    88. Bourguignon L, Lokeshwar VB, He J, Chen X, Bourguignon GJ. A CD44-like endothelial cell transmembrane glycoprotein (GP116) interacts with extracellular matrix and ankyrin. Mol Cell Biol. 1992 Oct; 12(10):4464-71. PMID: 1406635; PMCID: PMC360371.
    89. Lokeshwar VB, Bourguignon L. The involvement of Ca2+ and myosin light chain kinase in collagen-induced platelet activation. Cell Biol Int Rep. 1992 Sep; 16(9):883-97. PMID: 1423657.
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    90. Lokeshwar VB, Bourguignon L. Post-translational protein modification and expression of ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis. J Biol Chem. 1991 Sep 25; 266(27):17983-9. PMID: 1833390.
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    91. Bourguignon L, Kalomiris EL, Lokeshwar VB. Acylation of the lymphoma transmembrane glycoprotein, GP85, may be required for GP85-ankyrin interaction. J Biol Chem. 1991 Jun 25; 266(18):11761-5. PMID: 1828806.
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    92. Walker G, Bourguignon L. Membrane-associated 41-kDa GTP-binding protein in collagen-induced platelet activation. FASEB J. 1990 Aug; 4(11):2925-33. PMID: 2116341.
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    93. Bourguignon L, Walker G, Huang HS. Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping. J Immunol. 1990 Mar 15; 144(6):2242-52. PMID: 1968926.
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    94. Jy W, Fregien N, Bourguignon GJ, Bourguignon L. Role of Ca2+ in the regulation of hormone receptor exposure during lymphocyte activation. Biochim Biophys Acta. 1989 Aug 07; 983(2):153-60. PMID: 2503037.
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    95. Bourguignon GJ, Jy W, Bourguignon L. Electric stimulation of human fibroblasts causes an increase in Ca2+ influx and the exposure of additional insulin receptors. J Cell Physiol. 1989 Aug; 140(2):379-85. PMID: 2663886.
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    96. Kalomiris EL, Bourguignon L. Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding. J Biol Chem. 1989 May 15; 264(14):8113-9. PMID: 2470741.
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    97. Walker G, Kerrick WG, Bourguignon L. The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell. J Biol Chem. 1989 Jan 05; 264(1):496-500. PMID: 2909534.
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    98. Lopez DM, Blomberg BB, Padmanabhan RR, Bourguignon L. Nuclear disintegration of target cells by killer B lymphocytes from tumor-bearing mice. FASEB J. 1989 Jan; 3(1):37-43. PMID: 2783411.
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    99. Majercik MH, Bourguignon L. Insulin-induced myosin light-chain phosphorylation during receptor capping in IM-9 human B-lymphoblasts. Biochem J. 1988 Jun 15; 252(3):815-23. PMID: 3048249; PMCID: PMC1149220.
    100. Bourguignon L, Jy W, Majercik MH, Bourguignon GJ. Lymphocyte activation and capping of hormone receptors. J Cell Biochem. 1988 Jun; 37(2):131-50. PMID: 3135294.
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    101. Maurer DR, Majercik MH, Bourguignon L. Effect of cyclic AMP on human blood platelets: induction of pseudopod formation and protein phosphorylation. Cell Biol Int Rep. 1988 Apr; 12(4):271-88. PMID: 2841028.
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    102. Kalomiris EL, Bourguignon L. Mouse T lymphoma cells contain a transmembrane glycoprotein (GP85) that binds ankyrin. J Cell Biol. 1988 Feb; 106(2):319-27. PMID: 2963010; PMCID: PMC2114978.
    103. Suchard SJ, Lo HK, Bourguignon L. Isolation of Thy-1 caps and analysis of their phospholipid composition in mouse T-lymphoma cells. J Cell Physiol. 1988 Jan; 134(1):67-77. PMID: 2826503.
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    104. Bourguignon GJ, Bourguignon L. Electric stimulation of protein and DNA synthesis in human fibroblasts. FASEB J. 1987 Nov; 1(5):398-402. PMID: 3678699.
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    105. Suchard SJ, Bourguignon L. Further characterization of a fodrin-containing transmembrane complex from mouse T-lymphoma cells. Biochim Biophys Acta. 1987 Jan 09; 896(1):35-46. PMID: 3491628.
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    106. Bourguignon L, Suchard SJ, Kalomiris EL. Lymphoma Thy-1 glycoprotein is linked to the cytoskeleton via a 4.1-like protein. J Cell Biol. 1986 Dec; 103(6 Pt 1):2529-40. PMID: 2877998; PMCID: PMC2114603.
    107. Bourguignon L, Walker G, Suchard SJ, Balazovich K. A lymphoma plasma membrane-associated protein with ankyrin-like properties. J Cell Biol. 1986 Jun; 102(6):2115-24. PMID: 2940251; PMCID: PMC2114262.
    108. Bourguignon L, Balazovich K, Suchard SJ, Hindsgaul O, Pierce M. Endocytosis of mannose-6-phosphate binding sites by mouse T-lymphoma cells. J Cell Physiol. 1986 Apr; 127(1):146-61. PMID: 2870071.
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    109. Bourguignon LY, Walker G, Bourguignon L. Phorbol ester-induced phosphorylation of a transmembrane glycoprotein (GP 180) in human blood platelets. J Biol Chem. 1985 Sep 25; 260(21):11775-80. PMID: 4044578.
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    110. Majercik MH, Bourguignon L. Insulin receptor capping and its correlation with calmodulin-dependent myosin light chain kinase. J Cell Physiol. 1985 Sep; 124(3):403-10. PMID: 2931441.
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    111. Bourguignon L, Suchard SJ, Nagpal ML, Glenney JR. A T-lymphoma transmembrane glycoprotein (gp180) is linked to the cytoskeletal protein, fodrin. J Cell Biol. 1985 Aug; 101(2):477-87. PMID: 3874872; PMCID: PMC2113658.
    112. Bourguignon LY, Field S, Bourguignon L. Phosphorylation of a tropomyosin-like (30 KD) protein during platelet activation. J Cell Biochem. 1985; 29(1):19-30. PMID: 4055920.
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    113. Balazovich KJ, Lopez DM, Bourguignon L. The involvement of the cytoskeleton during antibody-dependent cellular cytotoxicity (ADCC). Cell Biol Int Rep. 1984 Nov; 8(11):923-38. PMID: 6542457.
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    114. Krishan A, Bourguignon L. Cell cycle related phenothiazine effects on adriamycin transport. Cell Biol Int Rep. 1984 Jun; 8(6):449-56. PMID: 6744425.
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    115. Bourguignon LY, Bourguignon L. Capping and the cytoskeleton. Int Rev Cytol. 1984; 87:195-224. PMID: 6325363.
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    116. Kerrick WG, Bourguignon L. Regulation of receptor capping in mouse lymphoma T cells by Ca2+-activated myosin light chain kinase. Proc Natl Acad Sci U S A. 1984 Jan; 81(1):165-9. PMID: 6582474; PMCID: PMC344631.
    117. Bourguignon L. Receptor capping in platelet membranes. Cell Biol Int Rep. 1984 Jan; 8(1):19-26. PMID: 6705052.
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    118. Howard JM, Eckert BS, Bourguignon L. Comparison of cytoskeletal organization in canine distemper virus-infected and uninfected cells. J Gen Virol. 1983 Nov; 64 (Pt 11):2379-85. PMID: 6358405.
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    119. Bourguignon L, Rubin RW, Krishan A. Cell cycle dependent receptor capping in mouse leukemic cells. Cell Biol Int Rep. 1983 Feb; 7(2):109-19. PMID: 6340839.
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    120. Bourguignon L, Hsing YC. The participation of adenylate cyclase in lymphocyte capping. Biochim Biophys Acta. 1983 Feb; 728(2):186-90. PMID: 6131691.
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    121. Bourguignon L, Kerrick WG. Receptor capping in mouse T-lymphoma cells: a Ca2+ and calmodulin-stimulated ATP-dependent process. J Membr Biol. 1983; 75(1):65-72. PMID: 6604166.
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    122. Bourguignon L, Pressman BC. Stimulation of lymphocyte receptor capping by the ionophore monensin. J Membr Biol. 1983; 73(1):91-3. PMID: 6134837.
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    123. Bourguignon L, Nagpal ML, Balazovich K, Guerriero V, Means AR. Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex. J Cell Biol. 1982 Dec; 95(3):793-7. PMID: 6984047; PMCID: PMC2112919.
    124. Bourguignon L, Balazovich K, Trowbridge IS, Hyman R. Immunoelectron microscopic localization of Thy-1 glycoprotein in wild type and Thy-1-negative lymphoma cells. Cell Biol Int Rep. 1982 Aug; 6(8):745-55. PMID: 6127167.
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    125. Bourguignon L, Butman BT. Morphological analysis of surface immunoglobulin biosynthesis in mouse B lymphoid cells using immunoelectron microscopy. Cell Immunol. 1982 Jul 15; 71(1):27-43. PMID: 6183010.
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    126. Bourguignon L, Butman BT. Intracellular localization of certain membrane glycoproteins in mouse T-lymphoma cells using immunoferritin staining of ultrathin frozen sections. J Cell Physiol. 1982 Feb; 110(2):203-12. PMID: 6121821.
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    127. Bourguignon L, Nagpal ML, Hsing YC. Phosphorylation of myosin light chain during capping of mouse T-lymphoma cells. J Cell Biol. 1981 Dec; 91(3 Pt 1):889-94. PMID: 6976966; PMCID: PMC2112802.
    128. Bourguignon GJ, Bourguignon L. Isolation and initial characterization of a lymphocyte cap structure. Biochim Biophys Acta. 1981 Aug 06; 646(1):109-18. PMID: 6268160.
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    129. Bourguignon LY, Bourguignon L. Immunocytochemical localization of intermediate filament proteins during lymphocyte capping. Cell Biol Int Rep. 1981 Aug; 5(8):783-9. PMID: 7026056.
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    130. Butman BT, Jacobsen T, Cabatu OG, Bourguignon L. The involvement of cAMP in lymphocyte capping. Cell Immunol. 1981 Jul 01; 61(2):397-403. PMID: 6265104.
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    131. Rader RL, Bourguignon L. The capping of liposomes on the surface of murine lymphoid and leukemic cells. Cell Mol Biol Incl Cyto Enzymol. 1981; 27(2-3):215-21. PMID: 7197586.
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    132. Bourguignon L, Balazovich K. Effect of the antidepressant drug-Stelazine on lymphocyte capping. Cell Biol Int Rep. 1980 Oct; 4(10):947-52. PMID: 6968248.
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    133. Butman BT, Bourguignon GJ, Bourguignon L. Lymphocyte capping induced by polycationized ferritin. J Cell Physiol. 1980 Oct; 105(1):7-15. PMID: 6253511.
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    134. Bourguignon L. Simultaneous localization of intracellular myosin and surface concanavalin A receptor clusters using immuno-electron microscopy. Cell Biol Int Rep. 1980 Jun; 4(6):541-7. PMID: 6994897.
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    135. Bourguignon L, Rozek RJ. Capping of concanavalin A receptors and their association with microfilaments in monolayer grown human fibroblastoid cells. Cell Tissue Res. 1980; 205(1):77-84. PMID: 7189138.
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    136. Bourguignon L. Biochemical analysis of ligand-induced receptor patching and capping using a novel immunolactoperoxidase iodination technique. J Cell Biol. 1979 Dec; 83(3):649-56. PMID: 391811; PMCID: PMC2110510.
    137. Bourguignon L, Rader RL, McMahon JT. Rapid separation of mouse T and B lymphocytes using wheat germ agglutinin. J Cell Physiol. 1979 Apr; 99(1):95-9. PMID: 313400.
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    138. Bourguignon L, Tokuyasu KT, Singer SJ. The capping of lymphocytes and other cells, studied by an improved method for immunofluorescence staining of frozen sections. J Cell Physiol. 1978 Jun; 95(3):239-57. PMID: 77276.
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    139. Bourguignon L, Hyman R, Trowbridge I, Singer SJ. Localization of T25 glycoprotein in wild-type and Thy 1- mutant cells by immunofluorescence and immunoelectron microscopy. J Exp Med. 1978 May 01; 147(5):1348-54. PMID: 77306; PMCID: PMC2184277.
    140. Bourguignon L, Hyman R, Trowbridge I, Singer SJ. Participation of histocompatibility antigens in capping of molecularly independent cell surface components by their specific antibodies. Proc Natl Acad Sci U S A. 1978 May; 75(5):2406-10. PMID: 307764; PMCID: PMC392562.
    141. Bourguignon L, Katz ER. Isolation and characterization of the RNA of membrane-bound ribosomes in Dictyostelium discoideum. J Gen Microbiol. 1978 May; 106(1):93-101. PMID: 565802.
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    142. Singer SJ, Ash JF, Bourguignon L, Heggeness MH, Louvard D. Transmembrane interactions and the mechanisms of transport of proteins across membranes. J Supramol Struct. 1978; 9(3):373-89. PMID: 748682.
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    143. Bourguignon L, Singer SJ. Transmembrane interactions and the mechanism of capping of surface receptors by their specific ligands. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):5031-5. PMID: 337308; PMCID: PMC432092.
    144. Bourguignon L, Palade GE. Incorporation of polypeptides into thylakoid membranes of Chlamydomonas reinhardtii. Cyclic variations. J Cell Biol. 1976 May; 69(2):327-44. PMID: 1262393; PMCID: PMC2109681.
    145. Katz ER, Bourguignon L. The cell cycle and its relationship to aggregation in the cellular slime mold, Dictyostelium discoideum. Dev Biol. 1974 Jan; 36(1):82-7. PMID: 4856682.
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