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Andrew Burghardt

Title(s)Specialist, Radiology
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-514-9658
EmailAndrew.Burghardt@ucsf.edu
ORCID ORCID Icon0000-0002-6343-4944 Additional info
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    Andrew Burghardt is an Imaging Scientist in the Department of Radiology and Biomedical Imaging at University of California, San Francisco where he serves as the Technical Director of the Quantitative Micro-Imaging Facility (QMIF). His area of expertise is high-resolution imaging computational analysis of musculoskeletal tissues. Osteoporosis, rheumatoid arthritis, and bone acquisition and development are the principle focus application areas for his research. As a Principal Investigator he has been awarded two R01s from NIH related to the standardization of HR-pQCT and the development of 3D statistical mapping techniques for population-based analyses of bone quality. He is a co-investigator on a number of significant NIH-funded multicenter skeletal health projects, including Osteoporotic Fractures in Men (MrOS), and the Epidemiology of Diabetes Interventions and Complications (EDIC). He was a member of the joint International Osteoporosis Foundation, ASBMR, and ECTS working group that produced guidelines for the use of HR-pQCT in skeletal health studies. Recently his research interests have expanded to include the development of standardized methods for using HR-pQCT in pediatric populations through collaborations with Mary Leonard at Stanford University and Babette Zemel at Children’s Hospital of Philadelphia. At UCSF he is developing a multidisciplinary program to study skeletal development in transgender youth. Finally, he is a founding member of the SPECTRA group (Study GrouP for XTrEme-CT in RA) that aims to develop standard methods to detect and quantify early signs of progression and treatment response in rheumatoid arthritis using HR-pQCT.

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    Multi-Parametric Spatial Assessment of Bone with HR-pQCT
    NIH/NIAMS R01AR068456Apr 1, 2017 - Mar 31, 2021
    Role: Co-Principal Investigator
    Bone quality by vQCT and HR-pQCT: translation to multi-center clinical research
    NIH/NIAMS R01AR060700Aug 1, 2011 - Jul 31, 2015
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Reliability and Change in Erosion Measurements by High-Resolution peripheral Quantitative Computed Tomography in a Longitudinal Dataset of Rheumatoid Arthritis Patients. J Rheumatol. 2020 Sep 15. Finzel S, Manske SL, Barnabe C, Burghardt AJ, Marotte H, Scharmga A, Hauge EM, Chapurlat R, Engelke K, Li X, van Teeffelen B, Conaghan PG, Stok KS. PMID: 32934121.
      View in: PubMed   Mentions:    Fields:    
    2. High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease. Front Med (Lausanne). 2020; 7:337. Klose-Jensen R, Tse JJ, Keller KK, Barnabe C, Burghardt AJ, Finzel S, Tam LS, Hauge EM, Stok KS, Manske SL. PMID: 32766262.
      View in: PubMed   Mentions:
    3. Guidelines for the assessment of bone density and microarchitecture in vivo using high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2020 Sep; 31(9):1607-1627. Whittier DE, Boyd SK, Burghardt AJ, Paccou J, Ghasem-Zadeh A, Chapurlat R, Engelke K, Bouxsein ML. PMID: 32458029.
      View in: PubMed   Mentions:    Fields:    
    4. Consensus approach for 3D joint space width of metacarpophalangeal joints of rheumatoid arthritis patients using high-resolution peripheral quantitative computed tomography. Quant Imaging Med Surg. 2020 Feb; 10(2):314-325. Stok KS, Burghardt AJ, Boutroy S, Peters MPH, Manske SL, Stadelmann V, Vilayphiou N, van den Bergh JP, Geusens P, Li X, Marotte H, van Rietbergen B, Boyd SK, Barnabe C. PMID: 32190559.
      View in: PubMed   Mentions:
    5. Objective measures of moderate to vigorous physical activity are associated with higher distal limb bone strength among elderly men. Bone. 2020 Mar; 132:115198. Langsetmo L, Burghardt AJ, Schousboe JT, Cawthon PM, Cauley JA, Lane NE, Orwoll ES, Ensrud KE. PMID: 31866494.
      View in: PubMed   Mentions:    Fields:    
    6. HR-pQCT Measures of Bone Microarchitecture Predict Fracture: Systematic Review and Meta-Analysis. J Bone Miner Res. 2020 Mar; 35(3):446-459. Mikolajewicz N, Bishop N, Burghardt AJ, Folkestad L, Hall A, Kozloff KM, Lukey PT, Molloy-Bland M, Morin SN, Offiah AC, Shapiro J, van Rietbergen B, Wager K, Willie BM, Komarova SV, Glorieux FH. PMID: 31643098.
      View in: PubMed   Mentions: 1     Fields:    
    7. Hip Fracture Discrimination Based on Statistical Multi-parametric Modeling (SMPM). Ann Biomed Eng. 2019 Nov; 47(11):2199-2212. Carballido-Gamio J, Yu A, Wang L, Su Y, Burghardt AJ, Lang TF, Cheng X. PMID: 31240508.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis. J Rheumatol. 2019 07; 46(7):676-684. Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X. PMID: 30770506.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Investigation of Semi-Coupled Dictionary Learning in 3-D Super Resolution HR-pQCT Imaging. IEEE Transactions on Radiation and Plasma Medical Sciences. 2018; 2(3):129-136. Li Y, Sixou B, Burghardt AJ, Peyrin F.View Publication.
    10. THE ASSOCIATION BETWEEN OBJECTIVELY MEASURED PHYSICAL ACTIVITY AND BONE STRENGTH AMONG OLDER MEN. Innovation in Aging. 2018 Nov 1; 2(suppl_1):304-305. L Langsetmo, K Ensrud, J Cauley, P Cawthon, A Burghardt. .
      View in: Publisher Site   Mentions:
    11. Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength. J Bone Miner Res. 2018 10; 33(10):1859-1869. Cauley JA, Burghardt AJ, Harrison SL, Cawthon PM, Schwartz AV, Connor EB, Ensrud KE, Langsetmo L, Majumdar S, Orwoll E. PMID: 29750848.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Volumetric Bone Mineral Density and Failure Load of Distal Limbs Predict Incident Clinical Fracture Independent HR-pQCT BMD and Failure Load Predicts Incident Clinical Fracture of FRAX and Clinical Risk Factors Among Older Men. J Bone Miner Res. 2018 07; 33(7):1302-1311. Langsetmo L, Peters KW, Burghardt AJ, Ensrud KE, Fink HA, Cawthon PM, Cauley JA, Schousboe JT, Barrett-Connor E, Orwoll ES. PMID: 29624722.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Weight loss in men in late life and bone strength and microarchitecture: a prospective study. Osteoporos Int. 2018 Jul; 29(7):1549-1558. Ensrud KE, Vo TN, Burghardt AJ, Schousboe JT, Cauley JA, Taylor BC, Hoffman AR, Orwoll ES, Lane NE, Langsetmo L. PMID: 29572622.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Chapter 55 High-Resolution Imaging Techniques for Bone Quality Assessment. Vitamin D. 2018 Jan 1; 1007-1041. Andrew J. Burghardt, Roland Krug, Sharmila Majumdar. .
      View in: Publisher Site   Mentions:
    15. High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men: a cross-sectional study. Osteoporos Int. 2018 01; 29(1):69-77. Langsetmo L, Shikany JM, Burghardt AJ, Cawthon PM, Orwoll ES, Cauley JA, Taylor BC, Schousboe JT, Bauer DC, Vo TN, Ensrud KE. PMID: 29063213.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Assessment of 3-month changes in bone microstructure under anti-TNFa therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT). Arthritis Res Ther. 2017 Oct 04; 19(1):222. Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X. PMID: 28978352.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. The SPECTRA Collaboration OMERACT Special Interest Group: Current Research and Future Directions. J Rheumatol. 2017 Dec; 44(12):1911-1915. Stok KS, Finzel S, Burghardt AJ, Conaghan PG, Barnabe C. PMID: 28765253.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions. Bone. 2017 Aug; 101:206-213. Ghasem-Zadeh A, Burghardt A, Wang XF, Iuliano S, Bonaretti S, Bui M, Zebaze R, Seeman E. PMID: 28502884.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions. Osteoporos Int. 2017 07; 28(7):2115-2128. Bonaretti S, Majumdar S, Lang TF, Khosla S, Burghardt AJ. PMID: 28391447.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Statistical Parametric Mapping of HR-pQCT Images: A Tool for Population-Based Local Comparisons of Micro-Scale Bone Features. Ann Biomed Eng. 2017 04; 45(4):949-962. Carballido-Gamio J, Bonaretti S, Kazakia GJ, Khosla S, Majumdar S, Lang TF, Burghardt AJ. PMID: 27830488.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    21. Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD. Bone Rep. 2016 Dec; 5:312-319. Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S. PMID: 28580402.
      View in: PubMed   Mentions:
    22. Determining Metacarpophalangeal Flexion Angle Tolerance for Reliable Volumetric Joint Space Measurements by High-resolution Peripheral Quantitative Computed Tomography. J Rheumatol. 2016 10; 43(10):1941-1944. Tom S, Frayne M, Manske SL, Burghardt AJ, Stok KS, Boyd SK, Barnabe C. PMID: 27698109.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro. J Bone Miner Res. 2016 12; 31(12):2173-2192. Heilmeier U, Hackl M, Skalicky S, Weilner S, Schroeder F, Vierlinger K, Patsch JM, Baum T, Oberbauer E, Lobach I, Burghardt AJ, Schwartz AV, Grillari J, Link TM. PMID: 27345526.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    24. Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training. Osteoporos Int. 2017 01; 28(1):245-257. Bonaretti S, Vilayphiou N, Chan CM, Yu A, Nishiyama K, Liu D, Boutroy S, Ghasem-Zadeh A, Boyd SK, Chapurlat R, McKay H, Shane E, Bouxsein ML, Black DM, Majumdar S, Orwoll ES, Lang TF, Khosla S, Burghardt AJ. PMID: 27475931.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Microarchitecture and Peripheral BMD are Impaired in Postmenopausal White Women With Fracture Independently of Total Hip T-Score: An International Multicenter Study. J Bone Miner Res. 2016 06; 31(6):1158-66. Boutroy S, Khosla S, Sornay-Rendu E, Zanchetta MB, McMahon DJ, Zhang CA, Chapurlat RD, Zanchetta J, Stein EM, Bogado C, Majumdar S, Burghardt AJ, Shane E. PMID: 26818785.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    26. SAT0545 The Effect of anti-TNF Alpha Treatment on Erosion Progression in Rheumatoid Arthritis by High-Resolution Peripheral Quantitative Computed Tomography: Three-Month Data. Annals of the Rheumatic Diseases. 2016 Jun 1; 75(Suppl 2):866. H. Choi, U. Heilmeier, M. Tanaka, A.J. Burghardt, N. Chanchek, T.M. Link, J. Graft, J.B. Imboden, X. Li. .
      View in: Publisher Site   Mentions:
    27. Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics. Osteoporos Int. 2016 09; 27(9):2791-2802. Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G. PMID: 27154435.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study. J Orthop Res. 2016 10; 34(10):1780-1789. Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S. PMID: 26895619.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    29. Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography. Quant Imaging Med Surg. 2015 Aug; 5(4):552-68. Carballido-Gamio J, Bonaretti S, Saeed I, Harnish R, Recker R, Burghardt AJ, Keyak JH, Harris T, Khosla S, Lang TF. PMID: 26435919.
      View in: PubMed   Mentions:
    30. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography. Int J Rheum Dis. 2017 Mar; 20(3):353-362. Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X. PMID: 25865349.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Spatial distribution of intracortical porosity varies across age and sex. Bone. 2015 Jun; 75:88-95. Nirody JA, Cheng KP, Parrish RM, Burghardt AJ, Majumdar S, Link TM, Kazakia GJ. PMID: 25701139.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures. Osteoporos Int. 2015 Apr; 26(4):1283-93. Heilmeier U, Carpenter DR, Patsch JM, Harnish R, Joseph GB, Burghardt AJ, Baum T, Schwartz AV, Lang TF, Link TM. PMID: 25582311.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    33. Novel anthropomorphic hip phantom corrects systemic interscanner differences in proximal femoral vBMD. Phys Med Biol. 2014 Dec 21; 59(24):7819-34. Bonaretti S, Carpenter RD, Saeed I, Burghardt AJ, Yu L, Bruesewitz M, Khosla S, Lang T. PMID: 25419618.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44. Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. PMID: 25425074.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    35. Correlation of structural abnormalities of the wrist and metacarpophalangeal joints evaluated by high-resolution peripheral quantitative computed tomography, 3 Tesla magnetic resonance imaging and conventional radiographs in rheumatoid arthritis. Int J Rheum Dis. 2015 Jul; 18(6):628-39. Lee CH, Srikhum W, Burghardt AJ, Virayavanich W, Imboden JB, Link TM, Li X. PMID: 25293500.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Population-based local multi-parametric comparisons of HR-pQCT studies. Journal of Orthopaedic Translation. 2014 Oct 1; 2(4):234-235. Julio Carballido-Gamio, Serena Bonaretti, Galateia J. Kazakia, Sundeep Khosla, Thomas F. Lang, Andrew J. Burghardt. .
      View in: Publisher Site   Mentions:
    37. Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int. 2014 Sep; 95(3):282-91. Lee TC, Burghardt AJ, Yao W, Lane NE, Majumdar S, Gullberg GT, Seo Y. PMID: 25106873.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    38. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. J Rheumatol. 2014 Sep; 41(9):1766-73. Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X. PMID: 25086074.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Three-dimensional analysis of subchondral cysts in hip osteoarthritis: an ex vivo HR-pQCT study. Bone. 2014 Sep; 66:140-5. Chiba K, Burghardt AJ, Osaki M, Majumdar S. PMID: 24925444.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    40. Latest Developments in Computed Tomographic Imaging in Joint Disease. Japanese Journal of Rheumatism and Joint Surgery. 2014 Jun 1; 31(2):85-89. Ko CHIBA, ?? ??, Andrew BURGHARDT, Sharmila MAJUMDAR, ?? ?. .
      View in: Publisher Site   Mentions:
    41. SAT0178 Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography (HR-PQCT): Reliability Exercise-2 (RELEX-2). Annals of the Rheumatic Diseases. 2014 Jun 1; 73(Suppl 2):654. C. Barnabe, H. Marotte, A. Scharmga, S. Kraus, A. Burghardt, E.-M. Hauge, S. Boutroy, D. Toepfer, K. Engelke, R. Kocijan, J. de Jong, X. Li, K. Stok, S. Finzel. .
      View in: Publisher Site   Mentions:
    42. The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT. Bone. 2014 Jun; 63:132-40. Kazakia GJ, Tjong W, Nirody JA, Burghardt AJ, Carballido-Gamio J, Patsch JM, Link T, Feeley BT, Ma CB. PMID: 24603002.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    43. Structural analysis of cortical porosity applied to HR-pQCT data. Med Phys. 2014 Jan; 41(1):013701. Tjong W, Nirody J, Burghardt AJ, Carballido-Gamio J, Kazakia GJ. PMID: 24387533.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    44. Quantification of lower leg arterial calcifications by high-resolution peripheral quantitative computed tomography. Bone. 2014 Jan; 58:42-7. Patsch JM, Zulliger MA, Vilayphou N, Samelson EJ, Cejka D, Diarra D, Berzaczy G, Burghardt AJ, Link TM, Weber M, Loewe C. PMID: 23954758.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    45. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Ann Biomed Eng. 2013 Dec; 41(12):2553-64. Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X. PMID: 23887879.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    46. Heterogeneity of bone microstructure in the femoral head in patients with osteoporosis: an ex vivo HR-pQCT study. Bone. 2013 Sep; 56(1):139-46. Chiba K, Burghardt AJ, Osaki M, Majumdar S. PMID: 23748104.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    47. High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group. Curr Osteoporos Rep. 2013 Jun; 11(2):136-46. Cheung AM, Adachi JD, Hanley DA, Kendler DL, Davison KS, Josse R, Brown JP, Ste-Marie LG, Kremer R, Erlandson MC, Dian L, Burghardt AJ, Boyd SK. PMID: 23525967.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    48. Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS). Osteoporos Int. 2013 Oct; 24(10):2591-601. Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM. PMID: 23589163.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    49. Multiple subchondral cyst formation has strong correlation with bone sclerosis: ex vivo HR-pQCT study. Osteoarthritis and Cartilage. 2013 Apr 1; 21:s193-s194. K. Chiba, A. Burghardt, M. Osaki, S. Majumdar. .
      View in: Publisher Site   Mentions:
    50. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. PMID: 23074145.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    51. Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis. J Rheumatol. 2013 Apr; 40(4):408-16. Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. PMID: 23418386.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    52. Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res. 2013 Feb; 28(2):313-24. Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, Link TM. PMID: 22991256.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
    53. Computational identification and quantification of trabecular microarchitecture classes by 3-D texture analysis-based clustering. Bone. 2013 May; 54(1):133-40. Valentinitsch A, Patsch JM, Burghardt AJ, Link TM, Majumdar S, Fischer L, Schueller-Weidekamm C, Resch H, Kainberger F, Langs G. PMID: 23313281.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    54. Age- and gender-related differences in cortical geometry and microstructure: Improved sensitivity by regional analysis. Bone. 2013 Feb; 52(2):623-31. Kazakia GJ, Nirody JA, Bernstein G, Sode M, Burghardt AJ, Majumdar S. PMID: 23142360.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    55. The effect of voxel size on high-resolution peripheral computed tomography measurements of trabecular and cortical bone microstructure. Med Phys. 2012 Apr; 39(4):1893-903. Tjong W, Kazakia GJ, Burghardt AJ, Majumdar S. PMID: 22482611.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    56. Microstructure analysis of subchondral trabecular bone in hip osteoarthritis - ex-vivo HR-pQCT study -. Osteoarthritis and Cartilage. 2012 Apr 1; 20:s223. K. Chiba, A. Burghardt, S. Majumdar. .
      View in: Publisher Site   Mentions:
    57. Vascular patterning and permeability in prostate cancer models with differing osteogenic properties. NMR Biomed. 2012 Jun; 25(6):843-51. Dafni H, Burghardt AJ, Majumdar S, Navone NM, Ronen SM. PMID: 22134886.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    58. Noninvasive imaging of bone microarchitecture. Ann N Y Acad Sci. 2011 Dec; 1240:77-87. Patsch JM, Burghardt AJ, Kazakia G, Majumdar S. PMID: 22172043.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    59. Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis. Magn Reson Imaging. 2012 Feb; 30(2):271-82. Pinney JR, Taylor C, Doan R, Burghardt AJ, Li X, Kim HT, Benjamin Ma C, Majumdar S. PMID: 22071411.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    60. Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture. Bone. 2012 Jan; 50(1):111-8. Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S. PMID: 22019605.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    61. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus? J Magn Reson Imaging. 2012 Jan; 35(1):117-24. Baum T, Yap SP, Karampinos DC, Nardo L, Kuo D, Burghardt AJ, Masharani UB, Schwartz AV, Li X, Link TM. PMID: 22190287.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    62. Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment. PLoS One. 2011; 6(8):e23638. Jobke B, Burghardt AJ, Muche B, Hahn M, Semler J, Amling M, Majumdar S, Busse B. PMID: 21858188.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    63. Morphology of the human vertebral endplate. J Orthop Res. 2012 Feb; 30(2):280-7. Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, Berven S, Majumdar S, Lotz JC. PMID: 21812023.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    64. High-resolution computed tomography for clinical imaging of bone microarchitecture. Clin Orthop Relat Res. 2011 Aug; 469(8):2179-93. Burghardt AJ, Link TM, Majumdar S. PMID: 21344275.
      View in: PubMed   Mentions: 54     Fields:    
    65. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5. Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. PMID: 21769960.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    66. Teriparatide in bisphosphonate-resistant osteoporosis: microarchitectural changes and clinical results after 6 and 18 months. Calcif Tissue Int. 2011 Aug; 89(2):130-9. Jobke B, Muche B, Burghardt AJ, Semler J, Link TM, Majumdar S. PMID: 21626160.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    67. Vitamin D, 3rd Edition, Feldman, Pike, and Adams. Chapter 50: High-Resolution Imaging Techniques for Bone Quality Assessment. 2011; I:891-925. Burghardt AJ, Krug R, Majumdar S.View Publication.
    68. Age-related differences in cortico-trabecular connectivity and load transfer in the distal radius measured in vivo by HR-pQCT. Bone. 2011 May 1; 48:s174. A.J. Burghardt, G.J. Kazakia?, T.M. Link, S. Majumdar. .
      View in: Publisher Site   Mentions:
    69. Longitudinal in vivo HR-pQCT assessment of the influence of non-weight bearing on bone quality. Bone. 2011 May 1; 48:s184. W. Tjong, M. Sode, A. Burghardt, S. Majumdar, B. Feeley, B. Ma, G. Kazakia. .
      View in: Publisher Site   Mentions:
    70. Human disc nucleus properties and vertebral endplate permeability. Spine (Phila Pa 1976). 2011 Apr 01; 36(7):512-20. Rodriguez AG, Slichter CK, Acosta FL, Rodriguez-Soto AE, Burghardt AJ, Majumdar S, Lotz JC. PMID: 21240044.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    71. Quantitative characterization of subject motion in HR-pQCT images of the distal radius and tibia. Bone. 2011 Jun 01; 48(6):1291-7. Sode M, Burghardt AJ, Pialat JB, Link TM, Majumdar S. PMID: 21421091.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    72. Chapter 50 High-Resolution Imaging Techniques for Bone Quality Assessment. Vitamin D. 2011 Jan 1; 891-925. Andrew J. Burghardt, Roland Krug, Sharmila Majumdar. .
      View in: Publisher Site   Mentions:
    73. Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD. J Biomech. 2011 Jan 11; 44(2):257-66. Kazakia GJ, Burghardt AJ, Link TM, Majumdar S. PMID: 21071031.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    74. Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women. Bone. 2011 Mar 01; 48(3):611-21. Folkesson J, Goldenstein J, Carballido-Gamio J, Kazakia G, Burghardt AJ, Rodriguez A, Krug R, de Papp AE, Link TM, Majumdar S. PMID: 21059422.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    75. High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2010 Nov; 95(11):5045-55. Burghardt AJ, Issever AS, Schwartz AV, Davis KA, Masharani U, Majumdar S, Link TM. PMID: 20719835.
      View in: PubMed   Mentions: 120     Fields:    Translation:Humans
    76. A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover. J Bone Miner Res. 2010 Dec; 25(12):2558-71. Burghardt AJ, Kazakia GJ, Sode M, de Papp AE, Link TM, Majumdar S. PMID: 20564242.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    77. Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone. 2010 Sep; 47(3):519-28. Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK. PMID: 20561906.
      View in: PubMed   Mentions: 131     Fields:    Translation:Humans
    78. High-resolution imaging techniques for the assessment of osteoporosis. Radiol Clin North Am. 2010 May; 48(3):601-21. Krug R, Burghardt AJ, Majumdar S, Link TM. PMID: 20609895.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    79. Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010 May; 25(5):983-93. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S. PMID: 19888900.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
    80. Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia. Bone. 2010 Jun; 46(6):1652-60. Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. PMID: 20188877.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    81. Contribution of the intra-specimen variations in tissue mineralization to PTH- and raloxifene-induced changes in stiffness of rat vertebrae. Bone. 2010 Apr; 46(4):1162-9. Easley SK, Jekir MG, Burghardt AJ, Li M, Keaveny TM. PMID: 20034599.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    82. Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats. Bone. 2010 May; 46(5):1267-74. Shahnazari M, Yao W, Dai W, Wang B, Ionova-Martin SS, Ritchie RO, Heeren D, Burghardt AJ, Nicolella DP, Kimiecik MG, Lane NE. PMID: 19931661.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    83. Trabecular bone structure analysis in the osteoporotic spine using a clinical in vivo setup for 64-slice MDCT imaging: comparison to microCT imaging and microFE modeling. J Bone Miner Res. 2009 Sep; 24(9):1628-37. Issever AS, Link TM, Kentenich M, Rogalla P, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Diederichs G. PMID: 19338434.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    84. Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard. Eur Radiol. 2010 Feb; 20(2):458-68. Issever AS, Link TM, Kentenich M, Rogalla P, Burghardt AJ, Kazakia GJ, Majumdar S, Diederichs G. PMID: 19711081.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    85. Accuracy of volumetric bone mineral density measurement in high-resolution peripheral quantitative computed tomography. Bone. 2009 Sep; 45(3):473-9. Sekhon K, Kazakia GJ, Burghardt AJ, Hermannsson B, Majumdar S. PMID: 19501201.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    86. Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2009 Dec; 20(12):2017-24. Burghardt AJ, Kazakia GJ, Link TM, Majumdar S. PMID: 19330422.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    87. Assessment of trabecular bone structure of the calcaneus using multi-detector CT: correlation with microCT and biomechanical testing. Bone. 2009 May; 44(5):976-83. Diederichs G, Link TM, Kentenich M, Schwieger K, Huber MB, Burghardt AJ, Majumdar S, Rogalla P, Issever AS. PMID: 19442610.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    88. Feasibility of measuring trabecular bone structure of the proximal femur using 64-slice multidetector computed tomography in a clinical setting. Calcif Tissue Int. 2008 Nov; 83(5):332-41. Diederichs G, Link T, Marie K, Huber M, Rogalla P, Burghardt A, Majumdar S, Issever A. PMID: 18855036.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    89. Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int. 2008 Aug; 83(2):129-38. Burghardt AJ, Kazakia GJ, Laib A, Majumdar S. PMID: 18685797.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    90. Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: comparison with synchrotron radiation microcomputed tomography and ash measurements. Med Phys. 2008 Jul; 35(7):3170-9. Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. PMID: 18697542.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    91. In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res. 2008 Apr; 23(4):463-74. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S. PMID: 18052756.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    92. In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T. J Magn Reson Imaging. 2008 Apr; 27(4):854-9. Krug R, Carballido-Gamio J, Banerjee S, Burghardt AJ, Link TM, Majumdar S. PMID: 18383263.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    93. Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36. Sode M, Burghardt AJ, Nissenson RA, Majumdar S. PMID: 18276202.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    94. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. 2008 Mar; 149(3):1329-37. Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA. PMID: 18048501.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    95. Assessment of trabecular bone structure comparing magnetic resonance imaging at 3 Tesla with high-resolution peripheral quantitative computed tomography ex vivo and in vivo. Osteoporos Int. 2008 May; 19(5):653-61. Krug R, Carballido-Gamio J, Burghardt AJ, Kazakia G, Hyun BH, Jobke B, Banerjee S, Huber M, Link TM, Majumdar S. PMID: 17992467.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    96. The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography. Calcif Tissue Int. 2007 Nov; 81(5):364-71. Davis KA, Burghardt AJ, Link TM, Majumdar S. PMID: 17952361.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    97. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res. 2007 Sep; 22(9):1329-37. Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD. PMID: 17539737.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    98. A local adaptive threshold strategy for high resolution peripheral quantitative computed tomography of trabecular bone. Ann Biomed Eng. 2007 Oct; 35(10):1678-86. Burghardt AJ, Kazakia GJ, Majumdar S. PMID: 17602299.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    99. Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment. Calcif Tissue Int. 2007 Jun; 80(6):366-73. Bauer JS, Link TM, Burghardt A, Henning TD, Mueller D, Majumdar S, Prevrhal S. PMID: 17520165.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    100. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. J Appl Physiol (1985). 2007 Jul; 103(1):125-31. Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP. PMID: 17412794.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    101. Wavelet-based characterization of vertebral trabecular bone structure from magnetic resonance images at 3 T compared with micro-computed tomographic measurements. Magn Reson Imaging. 2007 Apr; 25(3):392-8. Krug R, Carballido-Gamio J, Burghardt AJ, Haase S, Sedat JW, Moss WC, Majumdar S. PMID: 17371730.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    102. Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy. Bone. 2007 Jan; 40(1):160-8. Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S. PMID: 16905376.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    103. Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol. 2006 May; 189(2):279-87. Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD. PMID: 16648295.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    104. Fourier Transform Infrared Imaging of focal lesions in human osteoarthritic cartilage. Eur Cell Mater. 2005 Nov 22; 10:51-60; discussion 60. David-Vaudey E, Burghardt A, Keshari K, Brouchet A, Ries M, Majumdar S. PMID: 16307426.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    105. Trabecular architecture of lumbar vertebral pedicle. Spine (Phila Pa 1976). 2005 Jul 01; 30(13):1485-90. Inceoglu S, Burghardt A, Akbay A, Majumdar S, McLain RF. PMID: 15990660.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    106. Quantification of trabecular bone structure using magnetic resonance imaging at 3 Tesla--calibration studies using microcomputed tomography as a standard of reference. Calcif Tissue Int. 2005 May; 76(5):355-64. Sell CA, Masi JN, Burghardt A, Newitt D, Link TM, Majumdar S. PMID: 15868282.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    107. Wavelet Based Characterization of Vertebral Trabecular Bone Structure from MR Images of Specimen at 3 Tesla Compared to MicroCT Measurements. Conf Proc IEEE Eng Med Biol Soc. 2005; 2005:7040-3. Krug R, Carballido-Gamio J, Burghardt A, Haase S, Sedat J, Moss W, Majumdar S. PMID: 17281896.
      View in: PubMed   Mentions:    Fields:    
    108. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18111-6. Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. PMID: 15608054.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    109. Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44. J Bone Miner Res. 2005 Jan; 20(1):30-40. Cao JJ, Singleton PA, Majumdar S, Boudignon B, Burghardt A, Kurimoto P, Wronski TJ, Bourguignon LY, Halloran BP. PMID: 15619667.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    110. Contribution of inter-site variations in architecture to trabecular bone apparent yield strains. J Biomech. 2004 Sep; 37(9):1413-20. Morgan EF, Bayraktar HH, Yeh OC, Majumdar S, Burghardt A, Keaveny TM. PMID: 15275849.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    111. Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure. Eur Radiol. 2004 Aug; 14(8):1440-8. Majumdar S, Issever AS, Burghardt A, Lotz J, Arfelli F, Rigon L, Heitner G, Menk RH. PMID: 15232709.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    112. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. PMID: 15073337.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    113. Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae. Spine (Phila Pa 1976). 2003 Jan 15; 28(2):123-8. Issever AS, Walsh A, Lu Y, Burghardt A, Lotz JC, Majumdar S. PMID: 12544927.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    114. MicroCT evaluation of normal and osteoarthritic bone structure in human knee specimens. J Orthop Res. 2003 Jan; 21(1):6-13. Patel V, Issever AS, Burghardt A, Laib A, Ries M, Majumdar S. PMID: 12507574.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    115. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res. 2002 Jun; 17(6):1044-50. Halloran BP, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. PMID: 12054159.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    116. Sensitivity of damage predictions to tissue level yield properties and apparent loading conditions. J Biomech. 2001 May; 34(5):699-706. Niebur GL, Yuen JC, Burghardt AJ, Keaveny TM. PMID: 11311712.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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