Bernard Halloran, PhD

InstitutionUniversity of California San Francisco
Address4150 Clement St
San Francisco CA 94121
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    Collapse Biography 
    Collapse Education and Training
    University of Rochester, Rochester, NYPhD 1976Biophysics
    Montana State University, Bozeman, MTMS1972Physics
    Gonzaga University, Spokane, WABS1969Physics

    Collapse Overview 
    Collapse Overview
    Major programs in Dr. Halloran's laboratory include stem cell aging using animal models to study the effects of aging on stem cells and bone. Projects include work with natural products, development of orthopedic stem cell-based devices to facilitate spine fusion and bone healing. Students and postdoctoral fellows are encouraged to work collaboratively with other faculty in the Departments of Medicine, Bioengineering and Orthopedics.

    Collapse Research 
    Collapse Research Activities and Funding
    NIH/NIA R01AG007477Aug 1, 1988 - Mar 31, 1991
    Role: Principal Investigator
    California Dried Plum Board
    Bone regeneration and new approaches for spine fusion
    Johnson & Johnson
    Role: Co-Principle Investigator
    Heterotopic ossification
    Department of Defense
    Role: Principle investigator

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    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shoback DM, Heath H, Bikle DD, Chang W, Halloran B, Strewler G, Nissenson R. Claude D Arnaud, Jr, MD (1929-2016): ASBMR Loses a Founding Father. J Bone Miner Res. 2016 Dec; 31(12):2067-2068. PMID: 27566952.
      View in: PubMed
    2. Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran B. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 08; 34:73-82. PMID: 27239754.
      View in: PubMed
    3. Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA. Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. J Orthop Res. 2015 Aug; 33(8):1212-7. PMID: 25773760.
      View in: PubMed
    4. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. PMID: 25436890.
      View in: PubMed
    5. Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B. A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014 Feb; 32(2):183-8. PMID: 24136593.
      View in: PubMed
    6. Shahnazari M, Chu V, Wronski TJ, Nissenson RA, Halloran B. CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations. FASEB J. 2013 Sep; 27(9):3505-13. PMID: 23704087.
      View in: PubMed
    7. Rendina E, Hembree KD, Davis MR, Marlow D, Clarke SL, Halloran B, Lucas EA, Smith BJ. Dried plum's unique capacity to reverse bone loss and alter bone metabolism in postmenopausal osteoporosis model. PLoS One. 2013; 8(3):e60569. PMID: 23555991; PMCID: PMC3612052.
    8. Harris C, Roohk DJ, Fitch M, Boudignon BM, Halloran B, Hellerstein MK. Large increases in adipose triacylglycerol flux in Cushingoid CRH-Tg mice are explained by futile cycling. Am J Physiol Endocrinol Metab. 2013 Feb 01; 304(3):E282-93. PMID: 23211515; PMCID: PMC3566431.
    9. Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran B. Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1354-62. PMID: 23047986; PMCID: PMC3774081.
    10. Shahnazari M, Wronski T, Chu V, Williams A, Leeper A, Stolina M, Ke HZ, Halloran B. Early response of bone marrow osteoprogenitors to skeletal unloading and sclerostin antibody. Calcif Tissue Int. 2012 Jul; 91(1):50-8. PMID: 22644321.
      View in: PubMed
    11. Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran B, Bikle DD. Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling. J Bone Miner Res. 2011 Dec; 26(12):2948-58. PMID: 21932337; PMCID: PMC3222734.
    12. Shahnazari M, Dwyer D, Chu V, Asuncion F, Stolina M, Ominsky M, Kostenuik P, Halloran B. Bone turnover markers in peripheral blood and marrow plasma reflect trabecular bone loss but not endocortical expansion in aging mice. Bone. 2012 Mar; 50(3):628-37. PMID: 22154841.
      View in: PubMed
    13. Halloran B, Wronski TJ, VonHerzen DC, Chu V, Xia X, Pingel JE, Williams AA, Smith BJ. Dietary dried plum increases bone mass in adult and aged male mice. J Nutr. 2010 Oct; 140(10):1781-7. PMID: 20739449.
      View in: PubMed
    14. Hsiao EC, Boudignon BM, Halloran B, Nissenson RA, Conklin BR. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 2010 Mar; 25(3):584-93. PMID: 20200944; PMCID: PMC3153396.
    15. Wang L, Shi X, Zhao R, Halloran B, Clark DJ, Jacobs CR, Kingery WS. Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption. Bone. 2010 May; 46(5):1369-79. PMID: 19962460; PMCID: PMC2854244.
    16. Wang L, Zhao R, Shi X, Wei T, Halloran B, Clark DJ, Jacobs CR, Kingery WS. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone. 2009 Aug; 45(2):309-20. PMID: 19379851; PMCID: PMC2706279.
    17. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran B, Conklin BR, Nissenson RA. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. PMID: 18212126; PMCID: PMC2234117.
    18. Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran B, Clemens TL, Bikle DD. IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone. J Bone Miner Res. 2007 Sep; 22(9):1329-37. PMID: 17539737.
      View in: PubMed
    19. Cao JJ, Kurimoto P, Boudignon B, Rosen C, Lima F, Halloran B. Aging impairs IGF-I receptor activation and induces skeletal resistance to IGF-I. J Bone Miner Res. 2007 Aug; 22(8):1271-9. PMID: 17488198.
      View in: PubMed
    20. Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran B. Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading. J Appl Physiol (1985). 2007 Jul; 103(1):125-31. PMID: 17412794.
      View in: PubMed
    21. Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran B, Bikle DD. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res. 2006 Sep; 21(9):1350-8. PMID: 16939393.
      View in: PubMed
    22. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran B, Doty SB, Bikle DD. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006 Oct; 147(10):4753-61. PMID: 16857753.
      View in: PubMed
    23. Kazakia GJ, Nauman EA, Ebenstein DM, Halloran B, Keaveny TM. Effects of in vitro bone formation on the mechanical properties of a trabeculated hydroxyapatite bone substitute. J Biomed Mater Res A. 2006 Jun 15; 77(4):688-99. PMID: 16514602.
      View in: PubMed
    24. Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran B, Bikle DD. Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol. 2006 May; 189(2):279-87. PMID: 16648295.
      View in: PubMed
    25. Cao JJ, Wronski TJ, Iwaniec U, Phleger L, Kurimoto P, Boudignon B, Halloran B. Aging increases stromal/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse. J Bone Miner Res. 2005 Sep; 20(9):1659-68. PMID: 16059637.
      View in: PubMed
    26. Cao JJ, Singleton PA, Majumdar S, Boudignon B, Burghardt A, Kurimoto P, Wronski TJ, Bourguignon LY, Halloran B. Hyaluronan increases RANKL expression in bone marrow stromal cells through CD44. J Bone Miner Res. 2005 Jan; 20(1):30-40. PMID: 15619667.
      View in: PubMed
    27. Sakata T, Wang Y, Halloran B, Elalieh HZ, Cao J, Bikle DD. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. J Bone Miner Res. 2004 Mar; 19(3):436-46. PMID: 15040832.
      View in: PubMed
    28. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran B, Bikle DD, Nissenson RA. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. PMID: 14969393.
      View in: PubMed
    29. Bikle DD, Sakata T, Halloran B. The impact of skeletal unloading on bone formation. Gravit Space Biol Bull. 2003 Jun; 16(2):45-54. PMID: 12959131.
      View in: PubMed
    30. Cao J, Venton L, Sakata T, Halloran B. Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice. J Bone Miner Res. 2003 Feb; 18(2):270-7. PMID: 12568404.
      View in: PubMed
    31. Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran B. Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Miner Res. 2002 Sep; 17(9):1570-8. PMID: 12211426.
      View in: PubMed
    32. Halloran B, Ferguson VL, Simske SJ, Burghardt A, Venton LL, Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J Bone Miner Res. 2002 Jun; 17(6):1044-50. PMID: 12054159.
      View in: PubMed
    33. Kahn AJ, Halloran B, Wolkowitz O, Brizendine L. Dehydroepiandrosterone supplementation and bone turnover in middle-aged to elderly men. J Clin Endocrinol Metab. 2002 Apr; 87(4):1544-9. PMID: 11932279.
      View in: PubMed
    34. Halloran B, Udén P, Duh QY, Kikuchi S, Wieder T, Cao J, Clark O. Parathyroid gland volume increases with postmaturational aging in the rat. Am J Physiol Endocrinol Metab. 2002 Mar; 282(3):E557-63. PMID: 11832357.
      View in: PubMed