Massimo Scanziani, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Understanding V1 circuit dynamics and computations
    NIH/NINDS U19NS107613Sep 15, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Neural Circuits for the Cortical Control of the Optokinetic Reflex
    NIH/NEI R01EY025668May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Classifying Cortical Neurons by Correlating Transcriptome with Function
    NIH/NIMH U01MH105959Sep 26, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Dynamic Properties of Elementary Inhibitory Circuits
    NIH/NIMH R01MH070058Jul 1, 2004 - Apr 30, 2010
    Role: Principal Investigator
    NIH/NIMH R01MH071401Jul 1, 2004 - Apr 30, 2010
    Role: Principal Investigator
    Role of CREST in Cortical Development and Plasticity
    NIH/NIMH R01MH068578Sep 1, 2003 - Mar 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Beltramo R, Scanziani M. A collicular visual cortex: Neocortical space for an ancient midbrain visual structure. Science. 2019 01 04; 363(6422):64-69. PMID: 30606842.
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    2. Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Abbasi-Asl R, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-Llavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C. Visual physiology of the layer 4 cortical circuit in silico. PLoS Comput Biol. 2018 Nov; 14(11):e1006535. PMID: 30419013.
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    3. Lien AD, Scanziani M. Publisher Correction: Tuned thalamic excitation is amplified by visual cortical circuits. Nat Neurosci. 2018 Sep; 21(9):1292. PMID: 30013170.
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    4. Lien AD, Scanziani M. Cortical direction selectivity emerges at convergence of thalamic synapses. Nature. 2018 06; 558(7708):80-86. PMID: 29795349.
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    5. Resulaj A, Ruediger S, Olsen SR, Scanziani M. First spikes in visual cortex enable perceptual discrimination. Elife. 2018 Apr 16; 7. PMID: 29659352.
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    6. Liu BH, Huberman AD, Scanziani M. Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour. Nature. 2016 Oct 20; 538(7625):383-387. PMID: 27732573.
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    7. Biane JS, Takashima Y, Scanziani M, Conner JM, Tuszynski MH. Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning. Neuron. 2016 Mar 16; 89(6):1173-1179. PMID: 26948893; PMCID: PMC4795975 [Available on 03/16/17].
    8. Reinhold K, Lien AD, Scanziani M. Distinct recurrent versus afferent dynamics in cortical visual processing. Nat Neurosci. 2015 Dec; 18(12):1789-97. PMID: 26502263.
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    9. Wietek J, Beltramo R, Scanziani M, Hegemann P, Oertner TG, Wiegert JS. An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo. Sci Rep. 2015 10 07; 5:14807. PMID: 26443033; PMCID: PMC4595828.
    10. Biane JS, Scanziani M, Tuszynski MH, Conner JM. Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability. J Neurosci. 2015 Mar 18; 35(11):4719-28. PMID: 25788688; PMCID: PMC4363396.
    11. Xue M, Atallah BV, Scanziani M. Equalizing excitation-inhibition ratios across visual cortical neurons. Nature. 2014 Jul 31; 511(7511):596-600. PMID: 25043046; PMCID: PMC4117808.
    12. Atallah BV, Scanziani M, Carandini M. Atallah et al. reply. Nature. 2014 Apr 03; 508(7494):E3. PMID: 24695314.
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    13. Bortone DS, Olsen SR, Scanziani M. Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex. Neuron. 2014 Apr 16; 82(2):474-85. PMID: 24656931; PMCID: PMC4068343.
    14. Pouille F, Watkinson O, Scanziani M, Trevelyan AJ. The contribution of synaptic location to inhibitory gain control in pyramidal cells. Physiol Rep. 2013 Oct; 1(5):e00067. PMID: 24303159; PMCID: PMC3841021.
    15. Lien AD, Scanziani M. Tuned thalamic excitation is amplified by visual cortical circuits. Nat Neurosci. 2013 Sep; 16(9):1315-23. PMID: 23933748.
      View in: PubMed
    16. Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci. 2013 Aug; 16(8):1068-76. PMID: 23817549; PMCID: PMC3729586.
    17. DeFelipe J, López-Cruz PL, Benavides-Piccione R, Bielza C, Larrañaga P, Anderson S, Burkhalter A, Cauli B, Fairén A, Feldmeyer D, Fishell G, Fitzpatrick D, Freund TF, González-Burgos G, Hestrin S, Hill S, Hof PR, Huang J, Jones EG, Kawaguchi Y, Kisvárday Z, Kubota Y, Lewis DA, Marín O, Markram H, McBain CJ, Meyer HS, Monyer H, Nelson SB, Rockland K, Rossier J, Rubenstein JL, Rudy B, Scanziani M, Shepherd GM, Sherwood CC, Staiger JF, Tamás G, Thomson A, Wang Y, Yuste R, Ascoli GA. New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci. 2013 03; 14(3):202-16. PMID: 23385869; PMCID: PMC3619199.
    18. Adesnik H, Bruns W, Taniguchi H, Huang ZJ, Scanziani M. A neural circuit for spatial summation in visual cortex. Nature. 2012 Oct 11; 490(7419):226-31. PMID: 23060193; PMCID: PMC3621107.
    19. Trevelyan AJ, Bruns W, Mann EO, Crepel V, Scanziani M. The information content of physiological and epileptic brain activity. J Physiol. 2013 Feb 15; 591(4):799-805. PMID: 23027823; PMCID: PMC3591698.
    20. Olsen SR, Bortone DS, Adesnik H, Scanziani M. Gain control by layer six in cortical circuits of vision. Nature. 2012 Feb 22; 483(7387):47-52. PMID: 22367547; PMCID: PMC3636977.
    21. Atallah BV, Bruns W, Carandini M, Scanziani M. Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli. Neuron. 2012 Jan 12; 73(1):159-70. PMID: 22243754; PMCID: PMC3743079.
    22. Lien AD, Scanziani M. In vivo Labeling of Constellations of Functionally Identified Neurons for Targeted in vitro Recordings. Front Neural Circuits. 2011; 5:16. PMID: 22144948; PMCID: PMC3225774.
    23. Isaacson JS, Scanziani M. How inhibition shapes cortical activity. Neuron. 2011 Oct 20; 72(2):231-43. PMID: 22017986; PMCID: PMC3236361.
    24. Bagnall MW, Hull C, Bushong EA, Ellisman MH, Scanziani M. Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission. Neuron. 2011 Jul 14; 71(1):180-94. PMID: 21745647; PMCID: PMC3271052.
    25. Yuan Q, Isaacson JS, Scanziani M. Linking neuronal ensembles by associative synaptic plasticity. PLoS One. 2011; 6(6):e20486. PMID: 21738576; PMCID: PMC3126801.
    26. Apicella A, Yuan Q, Scanziani M, Isaacson JS. Pyramidal cells in piriform cortex receive convergent input from distinct olfactory bulb glomeruli. J Neurosci. 2010 Oct 20; 30(42):14255-60. PMID: 20962246; PMCID: PMC2972672.
    27. Adesnik H, Scanziani M. Lateral competition for cortical space by layer-specific horizontal circuits. Nature. 2010 Apr 22; 464(7292):1155-60. PMID: 20414303; PMCID: PMC2908490.
    28. Pouille F, Marin-Burgin A, Adesnik H, Atallah BV, Scanziani M. Input normalization by global feedforward inhibition expands cortical dynamic range. Nat Neurosci. 2009 Dec; 12(12):1577-85. PMID: 19881502.
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    29. Scanziani M, Häusser M. Electrophysiology in the age of light. Nature. 2009 Oct 15; 461(7266):930-9. PMID: 19829373.
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    30. Hull C, Isaacson JS, Scanziani M. Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. J Neurosci. 2009 Jul 15; 29(28):9127-36. PMID: 19605650; PMCID: PMC2753516.
    31. Hull C, Adesnik H, Scanziani M. Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. J Neurosci. 2009 Jul 15; 29(28):8991-5. PMID: 19605636; PMCID: PMC2760400.
    32. Atallah BV, Scanziani M. Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition. Neuron. 2009 May 28; 62(4):566-77. PMID: 19477157; PMCID: PMC2702525.
    33. Glickfeld LL, Roberts JD, Somogyi P, Scanziani M. Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis. Nat Neurosci. 2009 Jan; 12(1):21-3. PMID: 19029887; PMCID: PMC3505023.
    34. Glickfeld LL, Atallah BV, Scanziani M. Complementary modulation of somatic inhibition by opioids and cannabinoids. J Neurosci. 2008 Feb 20; 28(8):1824-32. PMID: 18287499; PMCID: PMC3505026.
    35. Kapfer C, Glickfeld LL, Atallah BV, Scanziani M. Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. Nat Neurosci. 2007 Jun; 10(6):743-53. PMID: 17515899; PMCID: PMC3518866.
    36. Hull C, Scanziani M. It's about time for thalamocortical circuits. Nat Neurosci. 2007 Apr; 10(4):400-2. PMID: 17387326; PMCID: PMC3572834.
    37. Glickfeld LL, Scanziani M. Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. Nat Neurosci. 2006 Jun; 9(6):807-15. PMID: 16648849; PMCID: PMC3509385.
    38. Gabernet L, Jadhav SP, Feldman DE, Carandini M, Scanziani M. Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition. Neuron. 2005 Oct 20; 48(2):315-27. PMID: 16242411.
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    39. Glickfeld LL, Scanziani M. Self-administering cannabinoids. Trends Neurosci. 2005 Jul; 28(7):341-3. PMID: 15979498.
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    40. Feller MB, Scanziani M. A precritical period for plasticity in visual cortex. Curr Opin Neurobiol. 2005 Feb; 15(1):94-100. PMID: 15721750.
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    41. Pouille F, Scanziani M. Routing of spike series by dynamic circuits in the hippocampus. Nature. 2004 Jun 17; 429(6993):717-23. PMID: 15170216.
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    42. Scanziani M. Competing on the edge. Trends Neurosci. 2002 Jun; 25(6):282-3. PMID: 12086738.
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    43. Arnth-Jensen N, Jabaudon D, Scanziani M. Cooperation between independent hippocampal synapses is controlled by glutamate uptake. Nat Neurosci. 2002 Apr; 5(4):325-31. PMID: 11896395.
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    44. Pouille F, Scanziani M. Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition. Science. 2001 Aug 10; 293(5532):1159-63. PMID: 11498596.
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    45. Jabaudon D, Scanziani M, Gähwiler BH, Gerber U. Acute decrease in net glutamate uptake during energy deprivation. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5610-5. PMID: 10805815; PMCID: PMC25876.
    46. Scanziani M. GABA spillover activates postsynaptic GABA(B) receptors to control rhythmic hippocampal activity. Neuron. 2000 Mar; 25(3):673-81. PMID: 10774734.
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    47. Heuss C, Scanziani M, Gähwiler BH, Gerber U. G-protein-independent signaling mediated by metabotropic glutamate receptors. Nat Neurosci. 1999 Dec; 2(12):1070-7. PMID: 10570483.
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    48. Jabaudon D, Shimamoto K, Yasuda-Kamatani Y, Scanziani M, Gähwiler BH, Gerber U. Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8733-8. PMID: 10411944; PMCID: PMC17585.
    49. Scanziani M, Gähwiler BH, Charpak S. Target cell-specific modulation of transmitter release at terminals from a single axon. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):12004-9. PMID: 9751780; PMCID: PMC21755.
    50. Hampson AJ, Bornheim LM, Scanziani M, Yost CS, Gray AT, Hansen BM, Leonoudakis DJ, Bickler PE. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. J Neurochem. 1998 Feb; 70(2):671-6. PMID: 9453561.
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    51. Scanziani M, Salin PA, Vogt KE, Malenka RC, Nicoll RA. Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature. 1997 Feb 13; 385(6617):630-4. PMID: 9024660.
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    52. Salin PA, Scanziani M, Malenka RC, Nicoll RA. Distinct short-term plasticity at two excitatory synapses in the hippocampus. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13304-9. PMID: 8917586; PMCID: PMC24088.
    53. Fortunato C, Debanne D, Scanziani M, Gähwiler BH, Thompson SM. Functional characterization and modulation of feedback inhibitory circuits in area CA3 of rat hippocampal slice cultures. Eur J Neurosci. 1996 Aug; 8(8):1758-68. PMID: 8921266.
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    54. Scanziani M, Malenka RC, Nicoll RA. Role of intercellular interactions in heterosynaptic long-term depression. Nature. 1996 Apr 04; 380(6573):446-50. PMID: 8602244.
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    55. Scanziani M, Nicoll RA, Malenka RC. Heterosynaptic long-term depression in the hippocampus. J Physiol Paris. 1996; 90(3-4):165-6. PMID: 9116660.
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    56. Scanziani M, Gahwiler BH, Thompson SM. Presynaptic inhibition of excitatory synaptic transmission by muscarinic and metabotropic glutamate receptor activation in the hippocampus: are Ca2+ channels involved? Neuropharmacology. 1995 Nov; 34(11):1549-57. PMID: 8606802.
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    57. Scanziani M, Debanne D, Müller M, Gähwiler BH, Thompson SM. Role of excitatory amino acid and GABAB receptors in the generation of epileptiform activity in disinhibited hippocampal slice cultures. Neuroscience. 1994 Aug; 61(4):823-32. PMID: 7838381.
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    58. Scanziani M, Gähwiler BH, Thompson SM. Presynaptic inhibition of excitatory synaptic transmission mediated by alpha adrenergic receptors in area CA3 of the rat hippocampus in vitro. J Neurosci. 1993 Dec; 13(12):5393-401. PMID: 7504723.
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    59. Thompson SM, Capogna M, Scanziani M. Presynaptic inhibition in the hippocampus. Trends Neurosci. 1993 Jun; 16(6):222-7. PMID: 7688163.
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    60. Scanziani M, Capogna M, Gähwiler BH, Thompson SM. Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus. Neuron. 1992 Nov; 9(5):919-27. PMID: 1358131.
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    61. Scanziani M, Gähwiler BH, Thompson SM. Paroxysmal inhibitory potentials mediated by GABAB receptors in partially disinhibited rat hippocampal slice cultures. J Physiol. 1991 Dec; 444:375-96. PMID: 1688032; PMCID: PMC1179939.