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Jeanne Paz, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

    Collapse Biography 
    Collapse Education and Training
    University Pierre et Marie CurieB.S.2002Cell Biology & Physiology
    University Pierre et Marie CurieM.S.2003Neuroscience
    University Pierre et Marie CuriePh.D.2007Neuroscience
    Stanford UniversityPostdoc2012Neurology
    Stanford UniversityResearch Associate (Staff) 2014Bioengineering and Neurology
    Collapse Awards and Honors
    University Pierre and Marie Curie2002Undergraduate studentship Award (Bourse de mérite)
    University Pierre and Marie Curie2003  - 2005Teaching assistant grant (Monitorat)
    University Pierre and Marie Curie2003  - 2007Graduate Scholarship from the French Ministry of Research and Technology, Neuroscience program
    French Society for Neuroscience2005Award for the best poster presentation in Neuroscience
    French Society for Neuroscience, France2007Award for the best Neuroscience PhD thesis in France (“Prix de these”)
    University Pierre and Marie Curie2007Linus Pauling Graduate Scholar promotion
    French National Board of Universities2008Qualification to teach as Assistant Professor in any French University
    Jackson Laboratories 2011Award to attend “Coming Together on Epilepsy Genetics: From Human to Model Organisms and Back”
    CURE (Citizens United for Research in Epilepsy)2012Young investigator travel award to attend the Gordon Epilepsy Conference, Waterville
    NIH/NINDS2012K99/R00 Career Development Award
    CURE (Citizens United for Research in Epilepsy)2013Challenge Award
    Michael Foundation2015Michael Prize 2015
    Nature Publishing Group2016  - 2018Top Reviewer
    Citizens United for Research in Epilepsy2018CURE Featured Speaker
    Vilcek Foundation2019Vilcek Prize for Creative Promise in Biomedical Science

    Collapse Overview 
    Collapse Overview
    Our lab studies how neural synchronization and circuit plasticity relate to adaptive and maladaptive behavior. Our interests span many levels of analysis, from the cell to the circuit to animal behavior. The current major focus of our lab is epileptogenesis, the process by which a normal brain develops epilepsy. Our ultimate goal is to identify epilepsy control points in the brain and to develop strategies to prevent epileptogenesis.

    Epilepsy occurs in a number of neurological diseases. However, the underlying mechanisms of the condition are not well understood. While many antiepileptic drugs exist, they often have side effects and are unable to fully suppress the highly disruptive and potentially fatal symptoms seen in patients with epilepsy. We seek to improve this situation by investigating the cellular, circuit, and molecular mechanisms by which brain injuries, cerebrovascular disease, and genetic mutations cause epilepsy. In addition, we are exploring new strategies that predict seizures and block the pathogenic loops that can emerge between the cortical and subcortical brain regions in animal models of epilepsy. We combine bioengineering, engineering, neurophysiology and signal processing to achieve these goals. In particular, we are using optogenetic tools, which allow the control of specific elements of intact biological systems using light, to interrogate cells and synaptic components involved in adaptive and maladaptive neural circuit oscillations (i.e. epileptic seizure). We then couple these results with our in vitro findings to determine the cellular and microcircuit mechanisms that relate to these oscillations. After we identify the neural circuit that alleviates symptoms, we then target these circuits in the behaving animal at the onset of abnormal brain activity in real-time.

    Our work (Paz et al., Nature Neuroscience 2012) was the first to reveal that seizures can be instantaneously aborted in real-time with closed-loop optogenetic control of a specific cell type. This work led us to identify thalamocortical neurons as novel targets that control post-stroke seizures in real-time without side effects. We are currently adapting this approach to reveal control points in the brain—regions, cells, and circuits—in other forms of epilepsy and cognitive disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Deconstruction and Control of Neural Circuits in Epilepsy
    Department of Defense, CDMRP, US ARMY W81XWH-16-1-0576Sep 30, 2016 - Sep 29, 2019
    Role: Role: Principal Investigator
    US-French Research Proposal: Experimental and theoretical investigation of the multi– scale emergence of parametric working memory in prefrontal cortex recurrent networks
    NSF NSF / CRCNS / ANRSep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator
    The Role of Inflammation in Post-stroke Epileptogenesis
    NIH/NINDS R01NS096369Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Closed-loop control of injury-induced and genetic seizures using temporally precise cell-type-specific optogenetic manipulation.
    CURE Challenge Award, Citizens United for Research in Epilepsy Nov 1, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Role of Thalamus in Post-stroke epileptogenesis
    NIH/NINDS R00NS078118Apr 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Role of Thalamus in Post-stroke epileptogenesis
    NIH/NINDS K99NS078118Apr 1, 2012 - Mar 31, 2014
    Role: Principal Investigator
    Role of Thalamus in post-stroke epileptogenesis
    Epilepsy Foundation Jan 1, 2009 - Jan 1, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Pai EL, Vogt D, Clemente-Perez A, McKinsey GL, Cho FS, Hu JS, Wimer M, Paul A, Fazel Darbandi S, Pla R, Nowakowski TJ, Goodrich LV, Paz JT, Rubenstein JLR. Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Rep. 2019 01 29; 26(5):1157-1173.e5. PMID: 30699346.
      View in: PubMed
    2. Ritter-Makinson S, Clemente-Perez A, Higashikubo B, Cho FS, Holden SS, Bennett E, Chkhaidze A, Eelkman Rooda OHJ, Cornet MC, Hoebeek FE, Yamakawa K, Cilio MR, Delord B, Paz JT. Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome. Cell Rep. 2019 Jan 22; 26(4):1071. PMID: 30673603.
      View in: PubMed
    3. Ritter-Makinson S, Clemente-Perez A, Higashikubo B, Cho FS, Holden SS, Bennett E, Chkhaidze A, Eelkman Rooda OHJ, Cornet MC, Hoebeek FE, Yamakawa K, Cilio MR, Delord B, Paz JT. Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome. Cell Rep. 2019 01 02; 26(1):54-64.e6. PMID: 30605686.
      View in: PubMed
    4. Rodriguez G, Sarazin M, Clemente A, Holden S, Paz JT, Delord B. Conditional Bistability, a Generic Cellular Mnemonic Mechanism for Robust and Flexible Working Memory Computations. J Neurosci. 2018 05 30; 38(22):5209-5219. PMID: 29712783.
      View in: PubMed
    5. Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018 03 16; 359(6381):1269-1273. PMID: 29420261.
      View in: PubMed
    6. Clemente-Perez A, Makinson SR, Higashikubo B, Brovarney S, Cho FS, Urry A, Holden SS, Wimer M, Dávid C, Fenno LE, Acsády L, Deisseroth K, Paz JT. Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms. Cell Rep. 2017 06 06; 19(10):2130-2142. PMID: 28591583.
      View in: PubMed
    7. Sorokin JM, Paz JT, Huguenard JR. Absence seizure susceptibility correlates with pre-ictal ß oscillations. J Physiol Paris. 2016 11; 110(4 Pt A):372-381. PMID: 28576554.
      View in: PubMed
    8. Sorokin JM, Davidson TJ, Frechette E, Abramian AM, Deisseroth K, Huguenard JR, Paz JT. Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron. 2017 Jan 04; 93(1):194-210. PMID: 27989462.
      View in: PubMed
    9. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 05; 165(4):921-35. PMID: 27114033.
      View in: PubMed
    10. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T. Voices of biotech. Nat Biotechnol. 2016 Mar; 34(3):270-5. PMID: 26963549.
      View in: PubMed
    11. Hiu T, Farzampour Z, Paz JT, Wang EH, Badgely C, Olson A, Micheva KD, Wang G, Lemmens R, Tran KV, Nishiyama Y, Liang X, Hamilton SA, O'Rourke N, Smith SJ, Huguenard JR, Bliss TM, Steinberg GK. Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain. 2016 Feb; 139(Pt 2):468-80. PMID: 26685158.
      View in: PubMed
    12. Paz JT, Huguenard JR. Microcircuits and their interactions in epilepsy: is the focus out of focus? Nat Neurosci. 2015 Mar; 18(3):351-9. PMID: 25710837.
      View in: PubMed
    13. Paz JT, Huguenard JR. Optogenetics and epilepsy: past, present and future. Epilepsy Curr. 2015 Jan-Feb; 15(1):34-8. PMID: 25678887.
      View in: PubMed
    14. Paz JT, Davidson TJ, Frechette ES, Delord B, Parada I, Peng K, Deisseroth K, Huguenard JR. Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci. 2013 Jan; 16(1):64-70. PMID: 23143518.
      View in: PubMed
    15. Paz JT, Huguenard JR. R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy. Epilepsy Curr. 2012 Mar; 12(2):75-6. PMID: 22473549.
      View in: PubMed
    16. Naudé J, Paz JT, Berry H, Delord B. A theory of rate coding control by intrinsic plasticity effects. PLoS Comput Biol. 2012 Jan; 8(1):e1002349. PMID: 22275858.
      View in: PubMed
    17. Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K, Huguenard JR. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci. 2011 Aug 21; 14(9):1167-73. PMID: 21857658.
      View in: PubMed
    18. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 2011 Jul 27; 477(7363):171-8. PMID: 21796121.
      View in: PubMed
    19. Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR. Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus. J Neurosci. 2010 Apr 14; 30(15):5465-79. PMID: 20392967.
      View in: PubMed
    20. Paz JT, Mahon S, Tiret P, Genet S, Delord B, Charpier S. Multiple forms of activity-dependent intrinsic plasticity in layer V cortical neurones in vivo. J Physiol. 2009 Jul 01; 587(Pt 13):3189-205. PMID: 19433575.
      View in: PubMed
    21. Paz JT, Chavez M, Saillet S, Deniau JM, Charpier S. Activity of ventral medial thalamic neurons during absence seizures and modulation of cortical paroxysms by the nigrothalamic pathway. J Neurosci. 2007 Jan 24; 27(4):929-41. PMID: 17251435.
      View in: PubMed
    22. Paz JT, Deniau JM, Charpier S. Rhythmic bursting in the cortico-subthalamo-pallidal network during spontaneous genetically determined spike and wave discharges. J Neurosci. 2005 Feb 23; 25(8):2092-101. PMID: 15728849.
      View in: PubMed