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Mazen Kheirbek, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentPsychiatry
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-514-8326
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    Collapse Biography 
    Collapse Education and Training
    Washington University in St. LouisBA
    University of ChicagoPhD
    Columbia UniversityPostdoc

    Collapse Overview 
    Collapse Overview
    Our primary goal is to delineate the neuronal circuits that generate emotional behavior. In particular, we are interested in those circuits that are disrupted in mood and anxiety-related disorders. We apply novel technologies to both monitor and control genetically identified neural networks in real time.


    Collapse Research 
    Collapse Research Activities and Funding
    Circuit and cellular mechanisms of adult neurogenesis in context encoding and discrimination
    NIH/NIMH R01MH111754Sep 15, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Hippocampal modulation of subcortical circuits in the control of emotional behavior
    NIH/NIMH R01MH108623Apr 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    2-photon microscope for in vivo functional imaging of neuronal circuits
    NIH S10OD018464Mar 1, 2015 - Feb 29, 2016
    Role: Principal Investigator
    Optogenetic dissection of dentate gyrus circuitry underlying anxiety
    NIH/NIMH K01MH099371Sep 27, 2012 - Jul 31, 2016
    Role: Principal Investigator
    Modulating plasticity in adult-born neurons of the dentate gyrus
    NIH/NIMH F32MH092101Jul 1, 2011 - Oct 31, 2012
    Role: Principal Investigator
    Adenylyl cyclase and plasticity in the striatum.
    NIH/NIMH F31MH076422Sep 29, 2006 - Sep 28, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Woods NI, Kheirbek M. The Small World of a Fear Memory. Neuron. 2017 Apr 19; 94(2):226-227. PMID: 28426955.
      View in: PubMed
    2. Biane JS, Kheirbek M. Imaging Adult Hippocampal Neurogenesis In Vivo. Neuropsychopharmacology. 2017 Jan; 42(1):373. PMID: 27909315.
      View in: PubMed
    3. Carvalho Poyraz F, Holzner E, Bailey MR, Meszaros J, Kenney L, Kheirbek M, Balsam PD, Kellendonk C. Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action. J Neurosci. 2016 Jun 01; 36(22):5988-6001. PMID: 27251620; PMCID: PMC4887564 [Available on 12/01/16].
    4. Tannenholz L, Hen R, Kheirbek M. GluN2B-Containg NMDA Receptors on Adult-Born Granule Cells Contribute to the Antidepressant Action of Fluoxetine. Front Neurosci. 2016; 10:242. PMID: 27303260; PMCID: PMC4885883.
    5. Danielson NB, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg AR, Drew LJ, Hen R, Losonczy A, Kheirbek M. Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding. Neuron. 2016 Apr 06; 90(1):101-12. PMID: 26971949; PMCID: PMC4962695 [Available on 04/06/17].
    6. Drew LJ, Kheirbek M, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R. Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons. Hippocampus. 2016 Jun; 26(6):763-78. PMID: 26662922; PMCID: PMC4867135 [Available on 06/01/17].
    7. Borgkvist A, Avegno EM, Wong MY, Kheirbek M, Sonders MS, Hen R, Sulzer D. Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice. Neuron. 2015 Sep 02; 87(5):976-88. PMID: 26335644; PMCID: PMC4559856.
    8. Kheirbek M. Finding the Roots of Adult Neurogenesis. Cell. 2015 Jun 18; 161(7):1500-2. PMID: 26091033.
      View in: PubMed
    9. Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek M, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell. 2015 Jan 15; 160(1-2):269-84. PMID: 25594183; PMCID: PMC4436082.
    10. Denny CA, Kheirbek M, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, Hen R. Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron. 2014 Jul 02; 83(1):189-201. PMID: 24991962; PMCID: PMC4169172.
    11. Kheirbek M, Hen R. Add neurons, subtract anxiety. Sci Am. 2014 Jul; 311(1):62-7. PMID: 24974712; PMCID: PMC4165637.
    12. Tannenholz L, Jimenez JC, Kheirbek M. Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. Front Behav Neurosci. 2014; 8:147. PMID: 24834033; PMCID: PMC4018538.
    13. Lovett-Barron M, Kaifosh P, Kheirbek M, Danielson N, Zaremba JD, Reardon TR, Turi GF, Hen R, Zemelman BV, Losonczy A. Dendritic inhibition in the hippocampus supports fear learning. Science. 2014 Feb 21; 343(6173):857-63. PMID: 24558155; PMCID: PMC4018419.
    14. Ahmari SE, Spellman T, Douglass NL, Kheirbek M, Simpson HB, Deisseroth K, Gordon JA, Hen R. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science. 2013 Jun 07; 340(6137):1234-9. PMID: 23744948; PMCID: PMC3954809.
    15. Kheirbek M, Hen R. (Radio)active neurogenesis in the human hippocampus. Cell. 2013 Jun 06; 153(6):1183-4. PMID: 23746833; PMCID: PMC4046854.
    16. Kheirbek M, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R. Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 2013 Mar 06; 77(5):955-68. PMID: 23473324; PMCID: PMC3595120.
    17. Kheirbek M, Klemenhagen KC, Sahay A, Hen R. Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci. 2012 Dec; 15(12):1613-20. PMID: 23187693; PMCID: PMC3638121.
    18. Kheirbek M, Tannenholz L, Hen R. NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination. J Neurosci. 2012 Jun 20; 32(25):8696-702. PMID: 22723709; PMCID: PMC3388607.
    19. Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek M, Burghardt NS, Fenton AA, Dranovsky A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature. 2011 Apr 28; 472(7344):466-70. PMID: 21460835; PMCID: PMC3084370.
    20. Kheirbek M, Hen R. Dorsal vs ventral hippocampal neurogenesis: implications for cognition and mood. Neuropsychopharmacology. 2011 Jan; 36(1):373-4. PMID: 21116266; PMCID: PMC3055508.
    21. Beeler JA, Cao ZF, Kheirbek M, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang X. Dopamine-dependent motor learning: insight into levodopa's long-duration response. Ann Neurol. 2010 May; 67(5):639-47. PMID: 20437561; PMCID: PMC3129617.
    22. Kheirbek M, Beeler JA, Chi W, Ishikawa Y, Zhuang X. A molecular dissociation between cued and contextual appetitive learning. Learn Mem. 2010 Mar; 17(3):148-54. PMID: 20189959; PMCID: PMC2832921.
    23. Kheirbek M, Britt JP, Beeler JA, Ishikawa Y, McGehee DS, Zhuang X. Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci. 2009 Sep 30; 29(39):12115-24. PMID: 19793969; PMCID: PMC2782774.
    24. Kheirbek M, Beeler JA, Ishikawa Y, Zhuang X. A cAMP pathway underlying reward prediction in associative learning. J Neurosci. 2008 Oct 29; 28(44):11401-8. PMID: 18971482; PMCID: PMC2610269.
    25. Beeler JA, Cao ZF, Kheirbek M, Zhuang X. Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway. Neuropsychopharmacology. 2009 Apr; 34(5):1149-61. PMID: 18704092; PMCID: PMC2752723.
    26. Kheirbek M. A molecular switch for induction of long-term depression of corticostriatal transmission. J Neurosci. 2007 Sep 12; 27(37):9824-5. PMID: 17855596.
      View in: PubMed
    27. Hale ME, Kheirbek M, Schriefer JE, Prince VE. Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons. J Neurosci. 2004 Mar 24; 24(12):3070-6. PMID: 15044546.
      View in: PubMed
    28. McClintock JM, Kheirbek M, Prince VE. Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development. 2002 May; 129(10):2339-54. PMID: 11973267.
      View in: PubMed
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