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Michael Lesh, MD

Title(s)Executive Director, HTI, Innovation Ventures
SchoolChancellor/EVC/FAS
EmailMichael.Lesh@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    Mass. Institute of Technology, Cambridge, MASB, SM1977Computer Sci, EE, Biomedical Eng.
    UCSF School of Medicine, SFMD1981Medicine
    UCSF School of Medicine, SF1984Residency, Medicine
    Hosp. Univ. of Pennsylvania, Philadelphia, PA1987Fellowship, Cardiovascular Disease
    Hosp. Univ. of Pennsylvania, Philadelphia, PA1989Fellowship, Cardiac Electrophysiology

    Collapse Overview 
    Collapse Overview
    Michael D. Lesh SM MD FACC is a cardiologist, inventor and entrepreneur. His 30+ year career spans both sides of translational medicine. He currently is Professor of Medicine and the campus-wide Executive Director of Health Technology Innovation in the Office of the Vice Chancellor at University of California San Francisco, utilizing his background to drive commercialization of discoveries made by UCSF faculty.

    Dr. Lesh’s research at UCSF led to the first AF pulmonary vein isolation(PVI) patent: 6,012,457 “Device and method for forming a circumferential conduction block at pulmonary vein.” Atrionix, founded to commercialize this innovation, was acquired by Biosense/Webster in 1999.
    Dr. Lesh was Founder, Chairman and CEO of Appriva Medical, which developed the first trans-catheter LAA occlusion device (PLAATO) to prevent stroke in patients with AF. The Appriva patents form the basis of the Watchman device. He was Founder, Chairman and CEO of Mitralife (acq. MDT), which developed a coronary sinus implant for MR and of Evera Medical, which fabricated biomaterials for reconstructive surgery. Dr. Lesh was Founder, Chairman and CEO of Middle Peak Medical (acquired, Symetis), which is developing a percutaneous mitral valve.
    Dr. Lesh was Independent Director at HeartScape (acq. by Roper) and Stentys (STNT, IPO 2011). He is currently Executive Director of several early-stage companies including Cordance (open BBB to treat CNS) and Abate Med (biotech for skin disease).

    Collapse Research 
    Collapse Research Activities and Funding
    A percutaneous cardiac implant to treat mitral valve regurgitation
    NIH R43HL117396May 1, 2013 - Apr 30, 2014
    Role: Principal Investigator
    NEW TECHNIQUE FOR QUANTIFYING ATRIAL FIBRILLATION
    NIH R44HL057699Jan 1, 1997 - Feb 28, 2003
    Role: Co-Investigator
    NEW TECHNIQUE FOR QUANTIFYING ATRIAL FIBRILLATION
    NIH R43HL057699Jan 1, 1997 - Nov 30, 1997
    Role: Co-Investigator
    ORGANIZATION OF ATRIAL FIBRILLATION IN A MODEL
    NIH/NHLBI R01HL055227Aug 1, 1996 - Jul 31, 1999
    Role: Principal Investigator
    REENTRY IN A COMPUTER MODEL OF HETEROGENOUS MYOCARDIUM
    NIH/NHLBI R29HL045664Jan 1, 1991 - Dec 31, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Hill AC, Lesh MD, Khairkhahan A. Novel mitral repair device for the treatment of severe mitral regurgitation: preclinical ovine acute and chronic implantation model. Innovations (Phila). 2014 Nov-Dec; 9(6):432-8. PMID: 25469459.
      View in: PubMed
    2. del Romeral LM, Stillson C, Lesh M, Botvinick E. The variable functional effects of the pacing site in normal and scarred ventricles. J Nucl Cardiol. 2009 Nov-Dec; 16(6):904-13. PMID: 19760474; PMCID: PMC2776147.
    3. del Romeral LM, Stillson C, Lesh M, Dae M, Botvinick E. The relationship of myocardial contraction and electrical excitation--the correlation between scintigraphic phase image analysis and electrophysiologic mapping. J Nucl Cardiol. 2009 Sep-Oct; 16(5):792-800. PMID: 19636652.
      View in: PubMed
    4. Ostermayer SH, Reisman M, Kramer PH, Matthews RV, Gray WA, Block PC, Omran H, Bartorelli AL, Della Bella P, Di Mario C, Pappone C, Casale PN, Moses JW, Poppas A, Williams DO, Meier B, Skanes A, Teirstein PS, Lesh MD, Nakai T, Bayard Y, Billinger K, Trepels T, Krumsdorf U, Sievert H. Percutaneous left atrial appendage transcatheter occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials. J Am Coll Cardiol. 2005 Jul 05; 46(1):9-14. PMID: 15992628.
      View in: PubMed
    5. Nakai T, Lesh M, Ostermayer S, Billinger K, Sievert H. An endovascular approach to cardioembolic stroke prevention in atrial fibrillation patients. Pacing Clin Electrophysiol. 2003 Jul; 26(7 Pt 2):1604-6. PMID: 12914609.
      View in: PubMed
    6. Nakai T, Lesh MD, Gerstenfeld EP, Virmani R, Jones R, Lee RJ. Percutaneous left atrial appendage occlusion (PLAATO) for preventing cardioembolism: first experience in canine model. Circulation. 2002 May 07; 105(18):2217-22. PMID: 11994258.
      View in: PubMed
    7. Sievert H, Lesh MD, Trepels T, Omran H, Bartorelli A, Della Bella P, Nakai T, Reisman M, DiMario C, Block P, Kramer P, Fleschenberg D, Krumsdorf U, Scherer D. Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience. Circulation. 2002 Apr 23; 105(16):1887-9. PMID: 11997272.
      View in: PubMed
    8. Kanagaratnam L, Tomassoni G, Schweikert R, Pavia S, Bash D, Beheiry S, Lesh M, Niebauer M, Saliba W, Chung M, Tchou P, Natale A. Empirical pulmonary vein isolation in patients with chronic atrial fibrillation using a three-dimensional nonfluoroscopic mapping system: long-term follow-up. Pacing Clin Electrophysiol. 2001 Dec; 24(12):1774-9. PMID: 11817811.
      View in: PubMed
    9. Gerstenfeld EP, Guerra P, Sparks PB, Hattori K, Lesh MD. Clinical outcome after radiofrequency catheter ablation of focal atrial fibrillation triggers. J Cardiovasc Electrophysiol. 2001 Aug; 12(8):900-8. PMID: 11513440.
      View in: PubMed
    10. Sippensgroenewegen A, Mlynash MD, Roithinger FX, Goseki Y, Lesh MD. Electrocardiographic analysis of ectopic atrial activity obscured by ventricular repolarization: P wave isolation using an automatic 62-lead QRST subtraction algorithm. J Cardiovasc Electrophysiol. 2001 Jul; 12(7):780-90. PMID: 11469428.
      View in: PubMed
    11. Saoudi N, Cosio F, Waldo A, Chen SA, Iesaka Y, Lesh M, Saksena S, Salerno J, Schoels W. Classification of atrial flutter and regular atrial tachycardia according to electrophysiologic mechanism and anatomic bases: a statement from a joint expert group from the Working Group of Arrhythmias of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. J Cardiovasc Electrophysiol. 2001 Jul; 12(7):852-66. PMID: 11469446.
      View in: PubMed
    12. Saoudi N, Cosío F, Waldo A, Chen SA, Iesaka Y, Lesh M, Saksena S, Salerno J, Schoels W. A classification of atrial flutter and regular atrial tachycardia according to electrophysiological mechanisms and anatomical bases; a Statement from a Joint Expert Group from The Working Group of Arrhythmias of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 2001 Jul; 22(14):1162-82. PMID: 11440490.
      View in: PubMed
    13. Yang Y, Cheng J, Bochoeyer A, Hamdan MH, Kowal RC, Page R, Lee RJ, Steiner PR, Saxon LA, Lesh MD, Modin GW, Scheinman MM. Atypical right atrial flutter patterns. Circulation. 2001 Jun 26; 103(25):3092-8. PMID: 11425774.
      View in: PubMed
    14. Domanski MJ, Zipes DP, Benditt DG, Camm AJ, Exner DV, Ezekowitz MD, Greene HL, Lesh MD, Miller JM, Pratt CM, Saksena S, Scheinman MM, Singh BN, Tracy CM, Waldo AL. Central clinical research issues in electrophysiology: report of the NASPE Committee. Pacing Clin Electrophysiol. 2001 Apr; 24(4 Pt 1):526-34. PMID: 11341097.
      View in: PubMed
    15. Natale A, Pisano E, Shewchik J, Bash D, Fanelli R, Potenza D, Santarelli P, Schweikert R, White R, Saliba W, Kanagaratnam L, Tchou P, Lesh M. First human experience with pulmonary vein isolation using a through-the-balloon circumferential ultrasound ablation system for recurrent atrial fibrillation. Circulation. 2000 Oct 17; 102(16):1879-82. PMID: 11034932.
      View in: PubMed
    16. Gerstenfeld EP, Lesh MD. Is there a role for biatrial pacing in the prevention of atrial arrhythmias? J Cardiovasc Electrophysiol. 2000 Oct; 11(10):1092-3. PMID: 11059971.
      View in: PubMed
    17. Ellis WS, SippensGroenewegen A, Auslander DM, Lesh MD. The role of the crista terminalis in atrial flutter and fibrillation: a computer modeling study. Ann Biomed Eng. 2000 Jul; 28(7):742-54. PMID: 11016412.
      View in: PubMed
    18. Viskin S, Fish R, Eldar M, Zeltser D, Lesh MD, Glick A, Belhassen B. Prevalence of the Brugada sign in idiopathic ventricular fibrillation and healthy controls. Heart. 2000 Jul; 84(1):31-6. PMID: 10862583.
      View in: PubMed
    19. SippensGroenewegen A, Lesh MD, Roithinger FX, Ellis WS, Steiner PR, Saxon LA, Lee RJ, Scheinman MM. Body surface mapping of counterclockwise and clockwise typical atrial flutter: a comparative analysis with endocardial activation sequence mapping. J Am Coll Cardiol. 2000 Apr; 35(5):1276-87. PMID: 10758970.
      View in: PubMed
    20. Yoshioka K, Gao DW, Chin M, Stillson C, Penades E, Lesh M, O'Connell W, Dae M. Heterogeneous sympathetic innervation influences local myocardial repolarization in normally perfused rabbit hearts. Circulation. 2000 Mar 07; 101(9):1060-6. PMID: 10704175.
      View in: PubMed
    21. Lesh MD, Guerra P, Roithinger FX, Goseki Y, Diederich C, Nau WH, Maguire M, Taylor K. Novel catheter technology for ablative cure of atrial fibrillation. J Interv Card Electrophysiol. 2000 Jan; 4 Suppl 1:127-39. PMID: 10590500.
      View in: PubMed
    22. Gerstenfeld EP, SippensGroenewegen A, Lux RL, Lesh MD. Derivation of an optimal lead set for measuring ectopic atrial activation from the pulmonary veins by using body surface mapping. J Electrocardiol. 2000; 33 Suppl:179-85. PMID: 11265719.
      View in: PubMed
    23. Roithinger FX, Karch MR, Steiner PR, SippensGroenewegen A, Lesh MD. The spatial dispersion of atrial refractoriness and atrial fibrillation vulnerability. J Interv Card Electrophysiol. 1999 Dec; 3(4):311-9. PMID: 10525245.
      View in: PubMed
    24. Roithinger FX, Steiner PR, Goseki Y, Sparks PB, Lesh MD. Electrophysiologic effects of selective right versus left atrial linear lesions in a canine model of chronic atrial fibrillation. J Cardiovasc Electrophysiol. 1999 Dec; 10(12):1564-74. PMID: 10636186.
      View in: PubMed
    25. Roithinger FX, Cheng J, SippensGroenewegen A, Lee RJ, Saxon LA, Scheinman MM, Lesh MD. Use of electroanatomic mapping to delineate transseptal atrial conduction in humans. Circulation. 1999 Oct 26; 100(17):1791-7. PMID: 10534466.
      View in: PubMed
    26. Lesh MD, Diederich C, Guerra PG, Goseki Y, Sparks PB. An anatomic approach to prevention of atrial fibrillation: pulmonary vein isolation with through-the-balloon ultrasound ablation (TTB-USA). Thorac Cardiovasc Surg. 1999 Aug; 47 Suppl 3:347-51. PMID: 10520766.
      View in: PubMed
    27. Guerra PG, Lesh MD. Catheter-ablative techniques for the treatment of atrial fibrillation. Curr Cardiol Rep. 1999 Jul; 1(2):142-8. PMID: 10980834.
      View in: PubMed
    28. Roithinger FX, Steiner PR, Goseki Y, Liese KS, Scholtz DB, Sippensgroenewegen A, Ursell P, Lesh MD. Low-power radiofrequency application and intracardiac echocardiography for creation of continuous left atrial linear lesions. J Cardiovasc Electrophysiol. 1999 May; 10(5):680-91. PMID: 10355924.
      View in: PubMed
    29. Roithinger FX, Lesh MD. What is the relationship of atrial flutter and fibrillation? Pacing Clin Electrophysiol. 1999 Apr; 22(4 Pt 1):643-54. PMID: 10234718.
      View in: PubMed
    30. Barron HV, Alam I, Lesh MD, Strunk A, Bass NM. Autonomic nervous system tone measured by baroreflex sensitivity is depressed in patients with end-stage liver disease. Am J Gastroenterol. 1999 Apr; 94(4):986-9. PMID: 10201470.
      View in: PubMed
    31. Glatter KA, Cheng J, Dorostkar P, Modin G, Talwar S, Al-Nimri M, Lee RJ, Saxon LA, Lesh MD, Scheinman MM. Electrophysiologic effects of adenosine in patients with supraventricular tachycardia. Circulation. 1999 Mar 02; 99(8):1034-40. PMID: 10051297.
      View in: PubMed
    32. Guerra PG, Lesh MD. The role of nonpharmacologic therapies for the treatment of atrial fibrillation. J Cardiovasc Electrophysiol. 1999 Mar; 10(3):450-60; quiz 488-94. PMID: 10210513.
      View in: PubMed
    33. Lesh MD, Kalman JM, Karch MR. Use of intracardiac echocardiography during electrophysiologic evaluation and therapy of atrial arrhythmias. J Cardiovasc Electrophysiol. 1998 Aug; 9(8 Suppl):S40-7. PMID: 9727675.
      View in: PubMed
    34. Hamdan MH, Kalman JM, Lesh MD, Lee RJ, Saxon LA, Dorostkar P, Scheinman MM. Narrow complex tachycardia with VA block: diagnostic and therapeutic implications. Pacing Clin Electrophysiol. 1998 Jun; 21(6):1196-206. PMID: 9633061.
      View in: PubMed
    35. Roithinger FX, SippensGroenewegen A, Karch MR, Steiner PR, Ellis WS, Lesh MD. Organized activation during atrial fibrillation in man: endocardial and electrocardiographic manifestations. J Cardiovasc Electrophysiol. 1998 May; 9(5):451-61. PMID: 9607452.
      View in: PubMed
    36. SippensGroenewegen A, Peeters HA, Jessurun ER, Linnenbank AC, Robles de Medina EO, Lesh MD, van Hemel NM. Body surface mapping during pacing at multiple sites in the human atrium: P-wave morphology of ectopic right atrial activation. Circulation. 1998 Feb 03; 97(4):369-80. PMID: 9468211.
      View in: PubMed
    37. Kalman JM, Olgin JE, Karch MR, Hamdan M, Lee RJ, Lesh MD. "Cristal tachycardias": origin of right atrial tachycardias from the crista terminalis identified by intracardiac echocardiography. J Am Coll Cardiol. 1998 Feb; 31(2):451-9. PMID: 9462592.
      View in: PubMed
    38. Saxon LA, Kerwin WF, Cahalan MK, Kalman JM, Olgin JE, Foster E, Schiller NB, Shinbane JS, Lesh MD, Merrick SH. Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function. J Cardiovasc Electrophysiol. 1998 Jan; 9(1):13-21. PMID: 9475573.
      View in: PubMed
    39. SippensGroenewegen A, Roithinger FX, Peeters HA, Linnenbank AC, van Hemel NM, Steiner PR, Lesh MD. Body surface mapping of atrial arrhythmias: atlas of paced P wave integral maps to localize the focal origin of right atrial tachycardia. J Electrocardiol. 1998; 31 Suppl:85-91. PMID: 9988010.
      View in: PubMed
    40. Lesh MD. Progress toward a catheter ablative cure of atrial fibrillation. J Electrocardiol. 1998; 31 Suppl:71-9. PMID: 9988008.
      View in: PubMed
    41. Olgin JE, Lesh M, Kalman J. Electrical mapping in combination with intracardiac ultrasound for electrical-anatomic correlation. J Electrocardiol. 1998; 30 Suppl:6-10. PMID: 9535473.
      View in: PubMed
    42. Shinbane JS, Lesh MD, Stevenson WG, Klitzner TS, Natterson PD, Wiener I, Ursell PC, Saxon LA. Anatomic and electrophysiologic relation between the coronary sinus and mitral annulus: implications for ablation of left-sided accessory pathways. Am Heart J. 1998 Jan; 135(1):93-8. PMID: 9453527.
      View in: PubMed
    43. Lesh MD, Kalman JM, Roithinger FX, Karch MR. Potential role of 'hybrid therapy' for atrial fibrillation. Semin Interv Cardiol. 1997 Dec; 2(4):267-71. PMID: 9704361.
      View in: PubMed
    44. Roithinger FX, Karch MR, Steiner PR, SippensGroenewegen A, Lesh MD. Relationship between atrial fibrillation and typical atrial flutter in humans: activation sequence changes during spontaneous conversion. Circulation. 1997 Nov 18; 96(10):3484-91. PMID: 9396445.
      View in: PubMed
    45. Olgin JE, Lesh MD. The laboratory evaluation and role of catheter ablation for patients with atrial flutter. Cardiol Clin. 1997 Nov; 15(4):677-88. PMID: 9403168.
      View in: PubMed
    46. Olgin JE, Kalman JM, Chin M, Stillson C, Maguire M, Ursel P, Lesh MD. Electrophysiological effects of long, linear atrial lesions placed under intracardiac ultrasound guidance. Circulation. 1997 Oct 21; 96(8):2715-21. PMID: 9355914.
      View in: PubMed
    47. Viskin S, Lesh MD, Eldar M, Fish R, Setbon I, Laniado S, Belhassen B. Mode of onset of malignant ventricular arrhythmias in idiopathic ventricular fibrillation. J Cardiovasc Electrophysiol. 1997 Oct; 8(10):1115-20. PMID: 9363814.
      View in: PubMed
    48. Kalman JM, Olgin JE, Karch MR, Lesh MD. Use of intracardiac echocardiography in interventional electrophysiology. Pacing Clin Electrophysiol. 1997 Sep; 20(9 Pt 1):2248-62. PMID: 9309751.
      View in: PubMed
    49. Lesh MD, Kalman JM, Saxon LA, Dorostkar PC. Electrophysiology of "incisional" reentrant atrial tachycardia complicating surgery for congenital heart disease. Pacing Clin Electrophysiol. 1997 Aug; 20(8 Pt 2):2107-11. PMID: 9272519.
      View in: PubMed
    50. Goette A, Honeycutt C, Hartung W, Fleischman S, Swanson D, Lesh M, Langberg JJ. [Transcatheter subendocardial infusion: a novel technique for ablation of atrial arrhythmias]. Herzschrittmacherther Elektrophysiol. 1997 Jun; 8(2):129-36. PMID: 19484525.
      View in: PubMed
    51. Hamdan MH, Kalman JM, Barron HV, Lesh MD. P-wave morphology during right atrial pacing before and after atrial flutter ablation--a new marker for success. Am J Cardiol. 1997 May 15; 79(10):1417-20. PMID: 9165174.
      View in: PubMed
    52. Barron HV, Khan HH, Viskin S, Heller K, Kalman JM, Scheinman MM, Lesh MD. Mortality benefit of implantable cardioverter-defibrillator therapy in patients with persistent malignant ventricular arrhythmias despite amiodarone treatment. Am J Cardiol. 1997 May 01; 79(9):1180-4. PMID: 9164881.
      View in: PubMed
    53. Wood KA, Eisenberg SJ, Kalman JM, Drew BJ, Saxon LA, Lee RJ, Lesh MD, Scheinman MM. Risk of thromboembolism in chronic atrial flutter. Am J Cardiol. 1997 Apr 15; 79(8):1043-7. PMID: 9114761.
      View in: PubMed
    54. Epstein LM, Jung S, Lee RJ, Lesh MD, Eisenberg SJ, Scheinman MM, Fitzpatrick AP. Slow AV nodal pathway ablation utilizing a unique temperature controlled radiofrequency energy system. Pacing Clin Electrophysiol. 1997 Mar; 20(3 Pt 1):664-70. PMID: 9080493.
      View in: PubMed
    55. Olgin JE, Kalman JM, Saxon LA, Lee RJ, Lesh MD. Mechanism of initiation of atrial flutter in humans: site of unidirectional block and direction of rotation. J Am Coll Cardiol. 1997 Feb; 29(2):376-84. PMID: 9014992.
      View in: PubMed
    56. Kalman JM, Olgin JE, Saxon LA, Lee RJ, Scheinman MM, Lesh MD. Electrocardiographic and electrophysiologic characterization of atypical atrial flutter in man: use of activation and entrainment mapping and implications for catheter ablation. J Cardiovasc Electrophysiol. 1997 Feb; 8(2):121-44. PMID: 9147698.
      View in: PubMed
    57. Kalman JM, Fitzpatrick AP, Olgin JE, Chin MC, Lee RJ, Scheinman MM, Lesh MD. Biophysical characteristics of radiofrequency lesion formation in vivo: dynamics of catheter tip-tissue contact evaluated by intracardiac echocardiography. Am Heart J. 1997 Jan; 133(1):8-18. PMID: 9006285.
      View in: PubMed
    58. Viskin S, Heller K, Barron HV, Kitzis I, Hamdan M, Olgin JE, Wong MJ, Grant SE, Lesh MD. Postextrasystolic U wave augmentation, a new marker of increased arrhythmic risk in patients without the long QT syndrome. J Am Coll Cardiol. 1996 Dec; 28(7):1746-52. PMID: 8962561.
      View in: PubMed
    59. Hamdan M, Van Hare GF, Fisher W, Gonzalez R, Dorostkar P, Lee R, Lesh M, Saxon L, Kalman J, Scheinman M. Selective catheter ablation of the tachycardia focus in patients with nonreentrant junctional tachycardia. Am J Cardiol. 1996 Dec 01; 78(11):1292-7. PMID: 8960595.
      View in: PubMed
    60. Lesh MD. Cost efficacy modeling of catheter reuse for percutaneous transluminal coronary angioplasty. J Am Coll Cardiol. 1996 Nov 15; 28(6):1640-1. PMID: 8917284.
      View in: PubMed
    61. Ellis WS, Eisenberg SJ, Auslander DM, Dae MW, Zakhor A, Lesh MD. Deconvolution: a novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue. Circulation. 1996 Nov 15; 94(10):2633-40. PMID: 8921811.
      View in: PubMed
    62. Lee RJ, Wong M, Siu A, Namekawa-Wong M, Epstein LM, Fitzpatrick AP, Grogin HR, Scheinman MM, Lesh MD. Long-term results of electrophysiologically guided sotalol therapy for life-threatening ventricular arrhythmias. Am Heart J. 1996 Nov; 132(5):973-8. PMID: 8892770.
      View in: PubMed
    63. Fitzpatrick AP, Lee RJ, Epstein LM, Lesh MD, Eisenberg S, Sheinman MM. Effect of patient characteristics on the yield of prolonged baseline head-up tilt testing and the additional yield of drug provocation. Heart. 1996 Nov; 76(5):406-11. PMID: 8963892; PMCID: PMC484570.
    64. Viskin S, Alla SR, Barron HV, Heller K, Saxon L, Kitzis I, Hare GF, Wong MJ, Lesh MD, Scheinman MM. Mode of onset of torsade de pointes in congenital long QT syndrome. J Am Coll Cardiol. 1996 Nov 01; 28(5):1262-8. PMID: 8890825.
      View in: PubMed
    65. Olgin JE, Kalman JM, Lesh MD. Conduction barriers in human atrial flutter: correlation of electrophysiology and anatomy. J Cardiovasc Electrophysiol. 1996 Nov; 7(11):1112-26. PMID: 8930744.
      View in: PubMed
    66. Gibb WJ, Wagner MB, Lesh MD. Modeling triggered cardiac activity: an analysis of the interactions between potassium blockade, rhythm pauses, and cellular coupling. Math Biosci. 1996 Oct 15; 137(2):101-33. PMID: 8885625.
      View in: PubMed
    67. Stark SI, Arthur A, Lesh MD. Radiofrequency catheter ablation of ventricular tachycardia in right ventricular cardiomyopathy: use of concealed entrainment to identify the slow conduction isthmus bounded by an aneurysm and the tricuspid annulus. J Cardiovasc Electrophysiol. 1996 Oct; 7(10):967-71. PMID: 8894939.
      View in: PubMed
    68. Goette A, Hartung W, Lesh M, Honeycutt C, Fleischman S, Swanson D, Langberg J. Transcatheter subendocardial infusion. A novel technique for mapping and ablation of ventricular myocardium. Circulation. 1996 Sep 15; 94(6):1449-55. PMID: 8823005.
      View in: PubMed
    69. kalman JM, Olgin JE, Karch MR, Lesh MD. Regional entrainment of atrial fibrillation in man. J Cardiovasc Electrophysiol. 1996 Sep; 7(9):867-76. PMID: 8884515.
      View in: PubMed
    70. Eldar M, Fitzpatrick AP, Ohad D, Smith MF, Hsu S, Whayne JG, Vered Z, Rotstein Z, Kordis T, Swanson DK, Chin M, Scheinman MM, Lesh MD, Greenspon AJ. Percutaneous multielectrode endocardial mapping during ventricular tachycardia in the swine model. Circulation. 1996 Sep 01; 94(5):1125-30. PMID: 8790055.
      View in: PubMed
    71. Kalman JM, Olgin JE, Saxon LA, Fisher WG, Lee RJ, Lesh MD. Activation and entrainment mapping defines the tricuspid annulus as the anterior barrier in typical atrial flutter. Circulation. 1996 Aug 01; 94(3):398-406. PMID: 8759082.
      View in: PubMed
    72. Olgin JE, Ursell P, Kao AK, Lesh MD. Pathological findings following slow pathway ablation for AV nodal reentrant tachycardia. J Cardiovasc Electrophysiol. 1996 Jul; 7(7):625-31. PMID: 8807408.
      View in: PubMed
    73. Saxon LA, Kalman JM, Olgin JE, Scheinman MM, Lee RJ, Lesh MD. Results of radiofrequency catheter ablation for atrial flutter. Am J Cardiol. 1996 May 01; 77(11):1014-6. PMID: 8644627.
      View in: PubMed
    74. Lesh MD, Kalman JM. To fumble flutter or tackle "tach"? Toward updated classifiers for atrial tachyarrhythmias. J Cardiovasc Electrophysiol. 1996 May; 7(5):460-6. PMID: 8722591.
      View in: PubMed
    75. Van Hare GF, Lesh MD, Ross BA, Perry JC, Dorostkar PC. Mapping and radiofrequency ablation of intraatrial reentrant tachycardia after the Senning or Mustard procedure for transposition ofthe great arteries. Am J Cardiol. 1996 May 01; 77(11):985-91. PMID: 8644650.
      View in: PubMed
    76. Lesh MD, Kalman JM, Olgin JE. New approaches to treatment of atrial flutter and tachycardia. J Cardiovasc Electrophysiol. 1996 Apr; 7(4):368-81. PMID: 8777486.
      View in: PubMed
    77. Barron HV, Lesh MD. Autonomic nervous system and sudden cardiac death. J Am Coll Cardiol. 1996 Apr; 27(5):1053-60. PMID: 8609321.
      View in: PubMed
    78. Fitzpatrick AP, Kourouyan HD, Siu A, Lee RJ, Lesh MD, Epstein LM, Griffin JC, Scheinman MM. Quality of life and outcomes after radiofrequency His-bundle catheter ablation and permanent pacemaker implantation: impact of treatment in paroxysmal and established atrial fibrillation. Am Heart J. 1996 Mar; 131(3):499-507. PMID: 8604629.
      View in: PubMed
    79. Kalman JM, VanHare GF, Olgin JE, Saxon LA, Stark SI, Lesh MD. Ablation of 'incisional' reentrant atrial tachycardia complicating surgery for congenital heart disease. Use of entrainment to define a critical isthmus of conduction. Circulation. 1996 Feb 01; 93(3):502-12. PMID: 8565168.
      View in: PubMed
    80. Kalman JM, Jue J, Sudhir K, Fitzgerald P, Yock P, Lesh MD. In vitro quantification of radiofrequency ablation lesion size using intracardiac echocardiography in dogs. Am J Cardiol. 1996 Jan 15; 77(2):217-9. PMID: 8546101.
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    81. Lesh MD, Kalman JM, Olgin JE, Ellis WS. The role of atrial anatomy in clinical atrial arrhythmias. J Electrocardiol. 1996; 29 Suppl:101-13. PMID: 9238386.
      View in: PubMed
    82. Kalman JM, Lee RJ, Fisher WG, Chin MC, Ursell P, Stillson CA, Lesh MD, Scheinman MM. Radiofrequency catheter modification of sinus pacemaker function guided by intracardiac echocardiography. Circulation. 1995 Nov 15; 92(10):3070-81. PMID: 7586278.
      View in: PubMed
    83. Lee RJ, Kalman JM, Fitzpatrick AP, Epstein LM, Fisher WG, Olgin JE, Lesh MD, Scheinman MM. Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia. Circulation. 1995 Nov 15; 92(10):2919-28. PMID: 7586260.
      View in: PubMed
    84. Tang CW, Scheinman MM, Van Hare GF, Epstein LM, Fitzpatrick AP, Lee RJ, Lesh MD. Use of P wave configuration during atrial tachycardia to predict site of origin. J Am Coll Cardiol. 1995 Nov 01; 26(5):1315-24. PMID: 7594049.
      View in: PubMed
    85. Wagner MB, Gibb WJ, Lesh MD. A model study of propagation of early afterdepolarizations. IEEE Trans Biomed Eng. 1995 Oct; 42(10):991-8. PMID: 8582729.
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    86. Olgin JE, Kalman JM, Fitzpatrick AP, Lesh MD. Role of right atrial endocardial structures as barriers to conduction during human type I atrial flutter. Activation and entrainment mapping guided by intracardiac echocardiography. Circulation. 1995 Oct 01; 92(7):1839-48. PMID: 7671368.
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    87. Ellis WS, Auslander DM, Lesh MD. Fractionated electrograms from a computer model of heterogeneously uncoupled anisotropic ventricular myocardium. Circulation. 1995 Sep 15; 92(6):1619-26. PMID: 7664449.
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    88. Eisenberg SJ, Scheinman MM, Dullet NK, Finkbeiner WE, Griffin JC, Eldar M, Franz MR, Gonzalez R, Kadish AH, Lesh MD. Sudden cardiac death and polymorphous ventricular tachycardia in patients with normal QT intervals and normal systolic cardiac function. Am J Cardiol. 1995 Apr 01; 75(10):687-92. PMID: 7900661.
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    89. Kusumoto FM, Lesh MD. Radiofrequency catheter ablation of an atriofascicular connection guided by direct recording of a Mahaim potential. Am Heart J. 1995 Mar; 129(3):614-6. PMID: 7872194.
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    90. Epstein LM, Lesh MD, Griffin JC, Lee RJ, Scheinman MM. A direct midseptal approach to slow atrioventricular nodal pathway ablation. Pacing Clin Electrophysiol. 1995 Jan; 18(1 Pt 1):57-64. PMID: 7700832.
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    91. Chu E, Kalman JM, Kwasman MA, Jue JC, Fitzgerald PJ, Epstein LM, Schiller NB, Yock PG, Lesh MD. Intracardiac echocardiography during radiofrequency catheter ablation of cardiac arrhythmias in humans. J Am Coll Cardiol. 1994 Nov 01; 24(5):1351-7. PMID: 7930260.
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    92. Scheinman MM, Gonzalez RP, Cooper MW, Lesh MD, Lee RJ, Epstein LM. Clinical and electrophysiologic features and role of catheter ablation techniques in adult patients with automatic atrioventricular junctional tachycardia. Am J Cardiol. 1994 Sep 15; 74(6):565-72. PMID: 8074039.
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    93. Gonzalez RP, Scheinman MM, Lesh MD, Helmy I, Torres V, Van Hare GF. Clinical and electrophysiologic spectrum of fascicular tachycardias. Am Heart J. 1994 Jul; 128(1):147-56. PMID: 8017268.
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    94. Grogin HR, Lee RJ, Kwasman M, Epstein LM, Schamp DJ, Lesh MD, Scheinman MM. Radiofrequency catheter ablation of atriofascicular and nodoventricular Mahaim tracts. Circulation. 1994 Jul; 90(1):272-81. PMID: 8026009.
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    95. Gibb WJ, Wagner MB, Lesh MD. Effects of simulated potassium blockade on the dynamics of triggered cardiac activity. J Theor Biol. 1994 Jun 07; 168(3):245-57. PMID: 8072293.
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    96. Fitzpatrick AP, Lesh MD, Epstein LM, Lee RJ, Siu A, Merrick S, Griffin JC, Scheinman MM. Electrophysiological laboratory, electrophysiologist-implanted, nonthoracotomy-implantable cardioverter/defibrillators. Circulation. 1994 Jun; 89(6):2503-8. PMID: 8205656.
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    97. Van Hare GF, Witherell CL, Lesh MD. Follow-up of radiofrequency catheter ablation in children: results in 100 consecutive patients. J Am Coll Cardiol. 1994 Jun; 23(7):1651-9. PMID: 8195527.
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    98. Epstein LM, Chiesa N, Wong MN, Lee RJ, Griffin JC, Scheinman MM, Lesh MD. Radiofrequency catheter ablation in the treatment of supraventricular tachycardia in the elderly. J Am Coll Cardiol. 1994 May; 23(6):1356-62. PMID: 8176093.
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    99. Coggins DL, Lee RJ, Sweeney J, Chein WW, Van Hare G, Epstein L, Gonzalez R, Griffin JC, Lesh MD, Scheinman MM. Radiofrequency catheter ablation as a cure for idiopathic tachycardia of both left and right ventricular origin. J Am Coll Cardiol. 1994 May; 23(6):1333-41. PMID: 8176091.
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    100. Lesh MD, Van Hare GF. Status of ablation in patients with atrial tachycardia and flutter. Pacing Clin Electrophysiol. 1994 May; 17(5 Pt 2):1026-33. PMID: 7518590.
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    101. Lesh MD, Van Hare GF, Epstein LM, Fitzpatrick AP, Scheinman MM, Lee RJ, Kwasman MA, Grogin HR, Griffin JC. Radiofrequency catheter ablation of atrial arrhythmias. Results and mechanisms. Circulation. 1994 Mar; 89(3):1074-89. PMID: 8124793.
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    102. Chu E, Fitzpatrick AP, Chin MC, Sudhir K, Yock PG, Lesh MD. Radiofrequency catheter ablation guided by intracardiac echocardiography. Circulation. 1994 Mar; 89(3):1301-5. PMID: 8124819.
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    103. Fitzpatrick AP, Gonzales RP, Lesh MD, Modin GW, Lee RJ, Scheinman MM. New algorithm for the localization of accessory atrioventricular connections using a baseline electrocardiogram. J Am Coll Cardiol. 1994 Jan; 23(1):107-16. PMID: 8277067.
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    104. Dae MW, Lesh MD. Radionuclide imaging tools for understanding arrhythmia mechanisms. J Electrocardiol. 1994; 27 Suppl:121-6. PMID: 7884347.
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    105. Lesh MD, Rankin JS. Coexisting Wolff-Parkinson-White syndrome and cardiac valve disease: a staged treatment approach with catheter ablation before operation. J Thorac Cardiovasc Surg. 1993 Dec; 106(6):1234-6. PMID: 8246575.
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    106. Chien WW, Wang YS, Epstein LM, Cohen TJ, Lesh MD, Griffin JC, Scheinman MM. Ventricular septal summit stimulation in atrioventricular nodal reentrant tachycardia. Am J Cardiol. 1993 Dec 01; 72(17):1268-73. PMID: 8256702.
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    107. Van Hare GF, Lesh MD, Stanger P. Radiofrequency catheter ablation of supraventricular arrhythmias in patients with congenital heart disease: results and technical considerations. J Am Coll Cardiol. 1993 Sep; 22(3):883-90. PMID: 8354828.
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    108. Chien WW, Lesh MD. Radiofrequency catheter ablation of an accessory pathway with discontinuous retrograde conduction: potential insight into mechanism of longitudinal dissociation. Am Heart J. 1993 Sep; 126(3 Pt 1):712-5. PMID: 8362731.
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    109. Lesh MD, Van Hare GF, Scheinman MM, Ports TA, Epstein LA. Comparison of the retrograde and transseptal methods for ablation of left free wall accessory pathways. J Am Coll Cardiol. 1993 Aug; 22(2):542-9. PMID: 8335827.
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    110. Jue J, Winslow T, Ossipov M, Lesh MD, Schiller NB. Effect of preexcitation on Doppler indexes of left ventricular filling. Am J Cardiol. 1993 Jun 15; 71(16):1462-4. PMID: 8517399.
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    111. Fitzpatrick AP, Lesh MD. A new statistical appraisal of baseline ECG features for localization of accessory pathways. J Electrocardiol. 1993; 26 Suppl:220-6. PMID: 8189129.
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    112. Lesh MD, Van Hare GF, Fitzpatrick AP, Griffin JC, Chu E. Curing reentrant atrial arrhythmias. Targeting protected zones of slow conduction by catheter ablation. J Electrocardiol. 1993; 26 Suppl:194-203. PMID: 8189124.
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    113. Scheinman MM, Wang YS, Van Hare GF, Lesh MD. Electrocardiographic and electrophysiologic characteristics of anterior, midseptal and right anterior free wall accessory pathways. J Am Coll Cardiol. 1992 Nov 01; 20(5):1220-9. PMID: 1401625.
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    114. Lesh MD, Coggins DL, Ports TA. Coronary air embolism complicating transseptal radiofrequency ablation of left free-wall accessory pathways. Pacing Clin Electrophysiol. 1992 Aug; 15(8):1105-8. PMID: 1381076.
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    115. Chien WW, Scheinman MM, Cohen TJ, Lesh MD. Importance of recording the right bundle branch deflection in the diagnosis of His-Purkinje reentrant tachycardia. Pacing Clin Electrophysiol. 1992 Jul; 15(7):1015-24. PMID: 1378593.
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    116. Lesh MD, Van Hare GF, Schamp DJ, Chien W, Lee MA, Griffin JC, Langberg JJ, Cohen TJ, Lurie KG, Scheinman MM. Curative percutaneous catheter ablation using radiofrequency energy for accessory pathways in all locations: results in 100 consecutive patients. J Am Coll Cardiol. 1992 May; 19(6):1303-9. PMID: 1564231.
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    117. Chien WW, Cohen TJ, Lee MA, Lesh MD, Griffin JC, Schiller NB, Scheinman MM. Electrophysiological findings and long-term follow-up of patients with the permanent form of junctional reciprocating tachycardia treated by catheter ablation. Circulation. 1992 Apr; 85(4):1329-36. PMID: 1555277.
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    118. Wang YS, Scheinman MM, Chien WW, Cohen TJ, Lesh MD, Griffin JC. Patients with supraventricular tachycardia presenting with aborted sudden death: incidence, mechanism and long-term follow-up. J Am Coll Cardiol. 1991 Dec; 18(7):1711-9. PMID: 1960318.
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    119. Cohen TJ, Chien WW, Lurie KG, Young C, Goldberg HR, Wang YS, Langberg JJ, Lesh MD, Lee MA, Griffin JC. Radiofrequency catheter ablation for treatment of bundle branch reentrant ventricular tachycardia: results and long-term follow-up. J Am Coll Cardiol. 1991 Dec; 18(7):1767-73. PMID: 1960328.
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    120. Lesh MD, Van Hare G, Kao AK, Scheinman MM. Radiofrequency catheter ablation for Wolff-Parkinson-White syndrome associated with a coronary sinus diverticulum. Pacing Clin Electrophysiol. 1991 Oct; 14(10):1479-84. PMID: 1721130.
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    121. Cohen TJ, Chien WW, Lurie KG, Lee MA, Lesh MD, Scheinman MM, Griffin JC. Implantable cardioverter defibrillator proarrhythmia: case report and review of the literature. Pacing Clin Electrophysiol. 1991 Sep; 14(9):1326-9. PMID: 1720524.
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    122. Van Hare GF, Lesh MD, Scheinman M, Langberg JJ. Percutaneous radiofrequency catheter ablation for supraventricular arrhythmias in children. J Am Coll Cardiol. 1991 Jun; 17(7):1613-20. PMID: 2033194.
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    123. Lesh MD, Langberg JJ, Griffin JC, Scheinman MM, Witherell CL. Pacemaker generator pseudomalfunction: an artifact of Holter monitoring. Pacing Clin Electrophysiol. 1991 May; 14(5 Pt 1):854-7. PMID: 1712963.
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    124. Lee MA, Morady F, Kadish A, Schamp DJ, Chin MC, Scheinman MM, Griffin JC, Lesh MD, Pederson D, Goldberger J. Catheter modification of the atrioventricular junction with radiofrequency energy for control of atrioventricular nodal reentry tachycardia. Circulation. 1991 Mar; 83(3):827-35. PMID: 1999034.
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    125. Langberg JJ, Chin M, Schamp DJ, Lee MA, Goldberger J, Pederson DN, Oeff M, Lesh MD, Griffin JC, Scheinman MM. Ablation of the atrioventricular junction with radiofrequency energy using a new electrode catheter. Am J Cardiol. 1991 Jan 15; 67(2):142-7. PMID: 1987715.
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    126. Gottlieb CD, Rosenthal ME, Stamato NJ, Frame LH, Lesh MD, Miller JM, Josephson ME. A quantitative evaluation of refractoriness within a reentrant circuit during ventricular tachycardia. Relation to termination. Circulation. 1990 Oct; 82(4):1289-95. PMID: 2401063.
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    127. Spear JF, Balke CW, Lesh MD, Kadish AH, Levine JL, Moore EN. Effect of cellular uncoupling by heptanol on conduction in infarcted myocardium. Circ Res. 1990 Jan; 66(1):202-17. PMID: 2295139.
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    128. Lesh MD, Pring M, Spear JF. Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study. Circ Res. 1989 Nov; 65(5):1426-40. PMID: 2805251.
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    129. Douglas PS, Berko B, Lesh M, Reichek N. Alterations in diastolic function in response to progressive left ventricular hypertrophy. J Am Coll Cardiol. 1989 Feb; 13(2):461-7. PMID: 2521506.
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    130. Balke CW, Lesh MD, Spear JF, Kadish A, Levine JH, Moore EN. Effects of cellular uncoupling on conduction in anisotropic canine ventricular myocardium. Circ Res. 1988 Nov; 63(5):879-92. PMID: 3180353.
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    131. Lesh MD, Spear JF, Simson MB. A computer model of the electrogram: what causes fractionation? J Electrocardiol. 1988; 21 Suppl:S69-73. PMID: 3216179.
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    132. Mansour JM, Lesh MD, Nowak MD, Simon SR. A three dimensional multi-segmental analysis of the energetics of normal and pathological human gait. J Biomech. 1982; 15(1):51-9. PMID: 7061527.
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