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Michael Lesh, MD

TitleExecutive Director, HTI
InstitutionUniversity of California San Francisco
DepartmentInnovation Ventures
Address600 16th St
San Francisco CA 94158
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    ORGANIZATION OF ATRIAL FIBRILLATION IN A MODEL
    NIH/NHLBI R01HL055227Aug 1, 1996 - Jul 31, 1999
    Role: Principal Investigator
    REENTRY IN A COMPUTER MODEL OF HETEROGENOUS MYOCARDIUM
    NIH/NHLBI R29HL045664Jan 1, 1991 - Dec 31, 1995
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hill AC, Lesh MD, Khairkhahan A. Novel mitral repair device for the treatment of severe mitral regurgitation: preclinical ovine acute and chronic implantation model. Innovations (Phila). 2014 Nov-Dec; 9(6):432-8. PMID: 25469459.
      View in: PubMed
    2. del Romeral LM, Stillson C, Lesh M, Botvinick E. The variable functional effects of the pacing site in normal and scarred ventricles. J Nucl Cardiol. 2009 Nov-Dec; 16(6):904-13. PMID: 19760474; PMCID: PMC2776147.
    3. Ostermayer SH, Reisman M, Kramer PH, Matthews RV, Gray WA, Block PC, Omran H, Bartorelli AL, Della Bella P, Di Mario C, Pappone C, Casale PN, Moses JW, Poppas A, Williams DO, Meier B, Skanes A, Teirstein PS, Lesh MD, Nakai T, Bayard Y, Billinger K, Trepels T, Krumsdorf U, Sievert H. Percutaneous left atrial appendage transcatheter occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials. J Am Coll Cardiol. 2005 Jul 05; 46(1):9-14. PMID: 15992628.
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    4. Nakai T, Lesh M, Ostermayer S, Billinger K, Sievert H. An endovascular approach to cardioembolic stroke prevention in atrial fibrillation patients. Pacing Clin Electrophysiol. 2003 Jul; 26(7 Pt 2):1604-6. PMID: 12914609.
      View in: PubMed
    5. Nakai T, Lesh MD, Gerstenfeld EP, Virmani R, Jones R, Lee RJ. Percutaneous left atrial appendage occlusion (PLAATO) for preventing cardioembolism: first experience in canine model. Circulation. 2002 May 07; 105(18):2217-22. PMID: 11994258.
      View in: PubMed
    6. Sievert H, Lesh MD, Trepels T, Omran H, Bartorelli A, Della Bella P, Nakai T, Reisman M, DiMario C, Block P, Kramer P, Fleschenberg D, Krumsdorf U, Scherer D. Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience. Circulation. 2002 Apr 23; 105(16):1887-9. PMID: 11997272.
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    7. Gerstenfeld EP, Guerra P, Sparks PB, Hattori K, Lesh MD. Clinical outcome after radiofrequency catheter ablation of focal atrial fibrillation triggers. J Cardiovasc Electrophysiol. 2001 Aug; 12(8):900-8. PMID: 11513440.
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    8. Sippensgroenewegen A, Mlynash MD, Roithinger FX, Goseki Y, Lesh MD. Electrocardiographic analysis of ectopic atrial activity obscured by ventricular repolarization: P wave isolation using an automatic 62-lead QRST subtraction algorithm. J Cardiovasc Electrophysiol. 2001 Jul; 12(7):780-90. PMID: 11469428.
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    9. Yang Y, Cheng J, Bochoeyer A, Hamdan MH, Kowal RC, Page R, Lee RJ, Steiner PR, Saxon LA, Lesh MD, Modin GW, Scheinman MM. Atypical right atrial flutter patterns. Circulation. 2001 Jun 26; 103(25):3092-8. PMID: 11425774.
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    10. Gerstenfeld EP, Lesh MD. Is there a role for biatrial pacing in the prevention of atrial arrhythmias? J Cardiovasc Electrophysiol. 2000 Oct; 11(10):1092-3. PMID: 11059971.
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    11. SippensGroenewegen A, Lesh MD, Roithinger FX, Ellis WS, Steiner PR, Saxon LA, Lee RJ, Scheinman MM. Body surface mapping of counterclockwise and clockwise typical atrial flutter: a comparative analysis with endocardial activation sequence mapping. J Am Coll Cardiol. 2000 Apr; 35(5):1276-87. PMID: 10758970.
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    12. Gerstenfeld EP, SippensGroenewegen A, Lux RL, Lesh MD. Derivation of an optimal lead set for measuring ectopic atrial activation from the pulmonary veins by using body surface mapping. J Electrocardiol. 2000; 33 Suppl:179-85. PMID: 11265719.
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    13. Lesh MD, Guerra P, Roithinger FX, Goseki Y, Diederich C, Nau WH, Maguire M, Taylor K. Novel catheter technology for ablative cure of atrial fibrillation. J Interv Card Electrophysiol. 2000 Jan; 4 Suppl 1:127-39. PMID: 10590500.
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    14. Roithinger FX, Karch MR, Steiner PR, SippensGroenewegen A, Lesh MD. The spatial dispersion of atrial refractoriness and atrial fibrillation vulnerability. J Interv Card Electrophysiol. 1999 Dec; 3(4):311-9. PMID: 10525245.
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    15. Roithinger FX, Steiner PR, Goseki Y, Sparks PB, Lesh MD. Electrophysiologic effects of selective right versus left atrial linear lesions in a canine model of chronic atrial fibrillation. J Cardiovasc Electrophysiol. 1999 Dec; 10(12):1564-74. PMID: 10636186.
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    16. Roithinger FX, Cheng J, SippensGroenewegen A, Lee RJ, Saxon LA, Scheinman MM, Lesh MD. Use of electroanatomic mapping to delineate transseptal atrial conduction in humans. Circulation. 1999 Oct 26; 100(17):1791-7. PMID: 10534466.
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    17. Lesh MD, Diederich C, Guerra PG, Goseki Y, Sparks PB. An anatomic approach to prevention of atrial fibrillation: pulmonary vein isolation with through-the-balloon ultrasound ablation (TTB-USA). Thorac Cardiovasc Surg. 1999 Aug; 47 Suppl 3:347-51. PMID: 10520766.
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    18. Roithinger FX, Steiner PR, Goseki Y, Liese KS, Scholtz DB, Sippensgroenewegen A, Ursell P, Lesh MD. Low-power radiofrequency application and intracardiac echocardiography for creation of continuous left atrial linear lesions. J Cardiovasc Electrophysiol. 1999 May; 10(5):680-91. PMID: 10355924.
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    19. Roithinger FX, Lesh MD. What is the relationship of atrial flutter and fibrillation? Pacing Clin Electrophysiol. 1999 Apr; 22(4 Pt 1):643-54. PMID: 10234718.
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    20. Glatter KA, Cheng J, Dorostkar P, Modin G, Talwar S, Al-Nimri M, Lee RJ, Saxon LA, Lesh MD, Scheinman MM. Electrophysiologic effects of adenosine in patients with supraventricular tachycardia. Circulation. 1999 Mar 02; 99(8):1034-40. PMID: 10051297.
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    21. Guerra PG, Lesh MD. The role of nonpharmacologic therapies for the treatment of atrial fibrillation. J Cardiovasc Electrophysiol. 1999 Mar; 10(3):450-60; quiz 488-94. PMID: 10210513.
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    22. Lesh MD, Kalman JM, Karch MR. Use of intracardiac echocardiography during electrophysiologic evaluation and therapy of atrial arrhythmias. J Cardiovasc Electrophysiol. 1998 Aug; 9(8 Suppl):S40-7. PMID: 9727675.
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    23. Hamdan MH, Kalman JM, Lesh MD, Lee RJ, Saxon LA, Dorostkar P, Scheinman MM. Narrow complex tachycardia with VA block: diagnostic and therapeutic implications. Pacing Clin Electrophysiol. 1998 Jun; 21(6):1196-206. PMID: 9633061.
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    24. Roithinger FX, SippensGroenewegen A, Karch MR, Steiner PR, Ellis WS, Lesh MD. Organized activation during atrial fibrillation in man: endocardial and electrocardiographic manifestations. J Cardiovasc Electrophysiol. 1998 May; 9(5):451-61. PMID: 9607452.
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    25. SippensGroenewegen A, Peeters HA, Jessurun ER, Linnenbank AC, Robles de Medina EO, Lesh MD, van Hemel NM. Body surface mapping during pacing at multiple sites in the human atrium: P-wave morphology of ectopic right atrial activation. Circulation. 1998 Feb 03; 97(4):369-80. PMID: 9468211.
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    26. Kalman JM, Olgin JE, Karch MR, Hamdan M, Lee RJ, Lesh MD. "Cristal tachycardias": origin of right atrial tachycardias from the crista terminalis identified by intracardiac echocardiography. J Am Coll Cardiol. 1998 Feb; 31(2):451-9. PMID: 9462592.
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    27. SippensGroenewegen A, Roithinger FX, Peeters HA, Linnenbank AC, van Hemel NM, Steiner PR, Lesh MD. Body surface mapping of atrial arrhythmias: atlas of paced P wave integral maps to localize the focal origin of right atrial tachycardia. J Electrocardiol. 1998; 31 Suppl:85-91. PMID: 9988010.
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    28. Saxon LA, Kerwin WF, Cahalan MK, Kalman JM, Olgin JE, Foster E, Schiller NB, Shinbane JS, Lesh MD, Merrick SH. Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function. J Cardiovasc Electrophysiol. 1998 Jan; 9(1):13-21. PMID: 9475573.
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    29. Lesh MD. Progress toward a catheter ablative cure of atrial fibrillation. J Electrocardiol. 1998; 31 Suppl:71-9. PMID: 9988008.
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    30. Lesh MD, Kalman JM, Roithinger FX, Karch MR. Potential role of 'hybrid therapy' for atrial fibrillation. Semin Interv Cardiol. 1997 Dec; 2(4):267-71. PMID: 9704361.
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    31. Roithinger FX, Karch MR, Steiner PR, SippensGroenewegen A, Lesh MD. Relationship between atrial fibrillation and typical atrial flutter in humans: activation sequence changes during spontaneous conversion. Circulation. 1997 Nov 18; 96(10):3484-91. PMID: 9396445.
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    32. Olgin JE, Kalman JM, Chin M, Stillson C, Maguire M, Ursel P, Lesh MD. Electrophysiological effects of long, linear atrial lesions placed under intracardiac ultrasound guidance. Circulation. 1997 Oct 21; 96(8):2715-21. PMID: 9355914.
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    33. Lesh MD, Kalman JM, Saxon LA, Dorostkar PC. Electrophysiology of "incisional" reentrant atrial tachycardia complicating surgery for congenital heart disease. Pacing Clin Electrophysiol. 1997 Aug; 20(8 Pt 2):2107-11. PMID: 9272519.
      View in: PubMed
    34. Barron HV, Khan HH, Viskin S, Heller K, Kalman JM, Scheinman MM, Lesh MD. Mortality benefit of implantable cardioverter-defibrillator therapy in patients with persistent malignant ventricular arrhythmias despite amiodarone treatment. Am J Cardiol. 1997 May 01; 79(9):1180-4. PMID: 9164881.
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    35. Wood KA, Eisenberg SJ, Kalman JM, Drew BJ, Saxon LA, Lee RJ, Lesh MD, Scheinman MM. Risk of thromboembolism in chronic atrial flutter. Am J Cardiol. 1997 Apr 15; 79(8):1043-7. PMID: 9114761.
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    36. Epstein LM, Jung S, Lee RJ, Lesh MD, Eisenberg SJ, Scheinman MM, Fitzpatrick AP. Slow AV nodal pathway ablation utilizing a unique temperature controlled radiofrequency energy system. Pacing Clin Electrophysiol. 1997 Mar; 20(3 Pt 1):664-70. PMID: 9080493.
      View in: PubMed
    37. Olgin JE, Kalman JM, Saxon LA, Lee RJ, Lesh MD. Mechanism of initiation of atrial flutter in humans: site of unidirectional block and direction of rotation. J Am Coll Cardiol. 1997 Feb; 29(2):376-84. PMID: 9014992.
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    38. Kalman JM, Olgin JE, Saxon LA, Lee RJ, Scheinman MM, Lesh MD. Electrocardiographic and electrophysiologic characterization of atypical atrial flutter in man: use of activation and entrainment mapping and implications for catheter ablation. J Cardiovasc Electrophysiol. 1997 Feb; 8(2):121-44. PMID: 9147698.
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    39. Kalman JM, Fitzpatrick AP, Olgin JE, Chin MC, Lee RJ, Scheinman MM, Lesh MD. Biophysical characteristics of radiofrequency lesion formation in vivo: dynamics of catheter tip-tissue contact evaluated by intracardiac echocardiography. Am Heart J. 1997 Jan; 133(1):8-18. PMID: 9006285.
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    40. Viskin S, Heller K, Barron HV, Kitzis I, Hamdan M, Olgin JE, Wong MJ, Grant SE, Lesh MD. Postextrasystolic U wave augmentation, a new marker of increased arrhythmic risk in patients without the long QT syndrome. J Am Coll Cardiol. 1996 Dec; 28(7):1746-52. PMID: 8962561.
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    41. Ellis WS, Eisenberg SJ, Auslander DM, Dae MW, Zakhor A, Lesh MD. Deconvolution: a novel signal processing approach for determining activation time from fractionated electrograms and detecting infarcted tissue. Circulation. 1996 Nov 15; 94(10):2633-40. PMID: 8921811.
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    42. Fitzpatrick AP, Lee RJ, Epstein LM, Lesh MD, Eisenberg S, Sheinman MM. Effect of patient characteristics on the yield of prolonged baseline head-up tilt testing and the additional yield of drug provocation. Heart. 1996 Nov; 76(5):406-11. PMID: 8963892; PMCID: PMC484570.
    43. Viskin S, Alla SR, Barron HV, Heller K, Saxon L, Kitzis I, Hare GF, Wong MJ, Lesh MD, Scheinman MM. Mode of onset of torsade de pointes in congenital long QT syndrome. J Am Coll Cardiol. 1996 Nov 01; 28(5):1262-8. PMID: 8890825.
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    44. Lee RJ, Wong M, Siu A, Namekawa-Wong M, Epstein LM, Fitzpatrick AP, Grogin HR, Scheinman MM, Lesh MD. Long-term results of electrophysiologically guided sotalol therapy for life-threatening ventricular arrhythmias. Am Heart J. 1996 Nov; 132(5):973-8. PMID: 8892770.
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    45. Kalman JM, Olgin JE, Saxon LA, Fisher WG, Lee RJ, Lesh MD. Activation and entrainment mapping defines the tricuspid annulus as the anterior barrier in typical atrial flutter. Circulation. 1996 Aug 01; 94(3):398-406. PMID: 8759082.
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    46. Olgin JE, Ursell P, Kao AK, Lesh MD. Pathological findings following slow pathway ablation for AV nodal reentrant tachycardia. J Cardiovasc Electrophysiol. 1996 Jul; 7(7):625-31. PMID: 8807408.
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    47. Saxon LA, Kalman JM, Olgin JE, Scheinman MM, Lee RJ, Lesh MD. Results of radiofrequency catheter ablation for atrial flutter. Am J Cardiol. 1996 May 01; 77(11):1014-6. PMID: 8644627.
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    48. Barron HV, Lesh MD. Autonomic nervous system and sudden cardiac death. J Am Coll Cardiol. 1996 Apr; 27(5):1053-60. PMID: 8609321.
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    49. Fitzpatrick AP, Kourouyan HD, Siu A, Lee RJ, Lesh MD, Epstein LM, Griffin JC, Scheinman MM. Quality of life and outcomes after radiofrequency His-bundle catheter ablation and permanent pacemaker implantation: impact of treatment in paroxysmal and established atrial fibrillation. Am Heart J. 1996 Mar; 131(3):499-507. PMID: 8604629.
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    50. Kalman JM, VanHare GF, Olgin JE, Saxon LA, Stark SI, Lesh MD. Ablation of 'incisional' reentrant atrial tachycardia complicating surgery for congenital heart disease. Use of entrainment to define a critical isthmus of conduction. Circulation. 1996 Feb 01; 93(3):502-12. PMID: 8565168.
      View in: PubMed
    51. Kalman JM, Lee RJ, Fisher WG, Chin MC, Ursell P, Stillson CA, Lesh MD, Scheinman MM. Radiofrequency catheter modification of sinus pacemaker function guided by intracardiac echocardiography. Circulation. 1995 Nov 15; 92(10):3070-81. PMID: 7586278.
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    52. Lee RJ, Kalman JM, Fitzpatrick AP, Epstein LM, Fisher WG, Olgin JE, Lesh MD, Scheinman MM. Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia. Circulation. 1995 Nov 15; 92(10):2919-28. PMID: 7586260.
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    53. Tang CW, Scheinman MM, Van Hare GF, Epstein LM, Fitzpatrick AP, Lee RJ, Lesh MD. Use of P wave configuration during atrial tachycardia to predict site of origin. J Am Coll Cardiol. 1995 Nov 01; 26(5):1315-24. PMID: 7594049.
      View in: PubMed
    54. Olgin JE, Kalman JM, Fitzpatrick AP, Lesh MD. Role of right atrial endocardial structures as barriers to conduction during human type I atrial flutter. Activation and entrainment mapping guided by intracardiac echocardiography. Circulation. 1995 Oct 01; 92(7):1839-48. PMID: 7671368.
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    55. Eisenberg SJ, Scheinman MM, Dullet NK, Finkbeiner WE, Griffin JC, Eldar M, Franz MR, Gonzalez R, Kadish AH, Lesh MD. Sudden cardiac death and polymorphous ventricular tachycardia in patients with normal QT intervals and normal systolic cardiac function. Am J Cardiol. 1995 Apr 01; 75(10):687-92. PMID: 7900661.
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    56. Epstein LM, Lesh MD, Griffin JC, Lee RJ, Scheinman MM. A direct midseptal approach to slow atrioventricular nodal pathway ablation. Pacing Clin Electrophysiol. 1995 Jan; 18(1 Pt 1):57-64. PMID: 7700832.
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    57. Scheinman MM, Gonzalez RP, Cooper MW, Lesh MD, Lee RJ, Epstein LM. Clinical and electrophysiologic features and role of catheter ablation techniques in adult patients with automatic atrioventricular junctional tachycardia. Am J Cardiol. 1994 Sep 15; 74(6):565-72. PMID: 8074039.
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    58. Grogin HR, Lee RJ, Kwasman M, Epstein LM, Schamp DJ, Lesh MD, Scheinman MM. Radiofrequency catheter ablation of atriofascicular and nodoventricular Mahaim tracts. Circulation. 1994 Jul; 90(1):272-81. PMID: 8026009.
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    59. Gibb WJ, Wagner MB, Lesh MD. Effects of simulated potassium blockade on the dynamics of triggered cardiac activity. J Theor Biol. 1994 Jun 07; 168(3):245-57. PMID: 8072293.
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    60. Fitzpatrick AP, Lesh MD, Epstein LM, Lee RJ, Siu A, Merrick S, Griffin JC, Scheinman MM. Electrophysiological laboratory, electrophysiologist-implanted, nonthoracotomy-implantable cardioverter/defibrillators. Circulation. 1994 Jun; 89(6):2503-8. PMID: 8205656.
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    61. Epstein LM, Chiesa N, Wong MN, Lee RJ, Griffin JC, Scheinman MM, Lesh MD. Radiofrequency catheter ablation in the treatment of supraventricular tachycardia in the elderly. J Am Coll Cardiol. 1994 May; 23(6):1356-62. PMID: 8176093.
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    62. Coggins DL, Lee RJ, Sweeney J, Chein WW, Van Hare G, Epstein L, Gonzalez R, Griffin JC, Lesh MD, Scheinman MM. Radiofrequency catheter ablation as a cure for idiopathic tachycardia of both left and right ventricular origin. J Am Coll Cardiol. 1994 May; 23(6):1333-41. PMID: 8176091.
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    63. Lesh MD, Van Hare GF. Status of ablation in patients with atrial tachycardia and flutter. Pacing Clin Electrophysiol. 1994 May; 17(5 Pt 2):1026-33. PMID: 7518590.
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    64. Chu E, Fitzpatrick AP, Chin MC, Sudhir K, Yock PG, Lesh MD. Radiofrequency catheter ablation guided by intracardiac echocardiography. Circulation. 1994 Mar; 89(3):1301-5. PMID: 8124819.
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    65. Lesh MD, Van Hare GF, Epstein LM, Fitzpatrick AP, Scheinman MM, Lee RJ, Kwasman MA, Grogin HR, Griffin JC. Radiofrequency catheter ablation of atrial arrhythmias. Results and mechanisms. Circulation. 1994 Mar; 89(3):1074-89. PMID: 8124793.
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    66. Fitzpatrick AP, Gonzales RP, Lesh MD, Modin GW, Lee RJ, Scheinman MM. New algorithm for the localization of accessory atrioventricular connections using a baseline electrocardiogram. J Am Coll Cardiol. 1994 Jan; 23(1):107-16. PMID: 8277067.
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    67. Chien WW, Wang YS, Epstein LM, Cohen TJ, Lesh MD, Griffin JC, Scheinman MM. Ventricular septal summit stimulation in atrioventricular nodal reentrant tachycardia. Am J Cardiol. 1993 Dec 01; 72(17):1268-73. PMID: 8256702.
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    68. Chien WW, Lesh MD. Radiofrequency catheter ablation of an accessory pathway with discontinuous retrograde conduction: potential insight into mechanism of longitudinal dissociation. Am Heart J. 1993 Sep; 126(3 Pt 1):712-5. PMID: 8362731.
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    69. Lesh MD, Van Hare GF, Fitzpatrick AP, Griffin JC, Chu E. Curing reentrant atrial arrhythmias. Targeting protected zones of slow conduction by catheter ablation. J Electrocardiol. 1993; 26 Suppl:194-203. PMID: 8189124.
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    70. Fitzpatrick AP, Lesh MD. A new statistical appraisal of baseline ECG features for localization of accessory pathways. J Electrocardiol. 1993; 26 Suppl:220-6. PMID: 8189129.
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    71. Lesh MD, Coggins DL, Ports TA. Coronary air embolism complicating transseptal radiofrequency ablation of left free-wall accessory pathways. Pacing Clin Electrophysiol. 1992 Aug; 15(8):1105-8. PMID: 1381076.
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    72. Lesh MD, Van Hare GF, Schamp DJ, Chien W, Lee MA, Griffin JC, Langberg JJ, Cohen TJ, Lurie KG, Scheinman MM. Curative percutaneous catheter ablation using radiofrequency energy for accessory pathways in all locations: results in 100 consecutive patients. J Am Coll Cardiol. 1992 May; 19(6):1303-9. PMID: 1564231.
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    73. Chien WW, Cohen TJ, Lee MA, Lesh MD, Griffin JC, Schiller NB, Scheinman MM. Electrophysiological findings and long-term follow-up of patients with the permanent form of junctional reciprocating tachycardia treated by catheter ablation. Circulation. 1992 Apr; 85(4):1329-36. PMID: 1555277.
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    74. Wang YS, Scheinman MM, Chien WW, Cohen TJ, Lesh MD, Griffin JC. Patients with supraventricular tachycardia presenting with aborted sudden death: incidence, mechanism and long-term follow-up. J Am Coll Cardiol. 1991 Dec; 18(7):1711-9. PMID: 1960318.
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    75. Cohen TJ, Chien WW, Lurie KG, Young C, Goldberg HR, Wang YS, Langberg JJ, Lesh MD, Lee MA, Griffin JC. Radiofrequency catheter ablation for treatment of bundle branch reentrant ventricular tachycardia: results and long-term follow-up. J Am Coll Cardiol. 1991 Dec; 18(7):1767-73. PMID: 1960328.
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    76. Lesh MD, Van Hare G, Kao AK, Scheinman MM. Radiofrequency catheter ablation for Wolff-Parkinson-White syndrome associated with a coronary sinus diverticulum. Pacing Clin Electrophysiol. 1991 Oct; 14(10):1479-84. PMID: 1721130.
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    77. Lesh MD, Langberg JJ, Griffin JC, Scheinman MM, Witherell CL. Pacemaker generator pseudomalfunction: an artifact of Holter monitoring. Pacing Clin Electrophysiol. 1991 May; 14(5 Pt 1):854-7. PMID: 1712963.
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