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Walter Finkbeiner, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPathology
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-8230
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1989 Graduate Division (Experimental Pathology)
    University of California, San Francisco Residency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Novel Small-Molecule Therapies for CF
    NIH/NIDDK P30DK072517Sep 15, 2005 - May 31, 2020
    Role: Co-Investigator
    ALTERATIONS IN AIRWAY SURFACE LIQUID IN CYSTIC FIBROSIS
    NIH P50HL060288Sep 1, 1998 - Aug 31, 2003
    Role: Co-Investigator
    CFTR AND AIRWAY PATHOLOGY OF CYSTIC FIBROSIS
    NIH P50HL042368Sep 30, 1988 - Aug 31, 1999
    Role: Co-Investigator
    STUDIES OF AIRWAY SUBMUCOSAL GLANDS AND EPITHELIAL CELLS
    NIH/NHLBI K08HL001387Mar 1, 1984 - Feb 28, 1989
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sun DI, Tasca A, Haas M, Baltazar G, Harland RM, Finkbeiner WE, Walentek P. Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia. Cells Tissues Organs. 2018 Oct 09; 1-14. PMID: 30300884.
      View in: PubMed
    2. Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators. J Cyst Fibros. 2018 Jun 11. PMID: 29903467.
      View in: PubMed
    3. Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS. ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS Discov. 2018 Mar 01; 2472555218763310. PMID: 29533733.
      View in: PubMed
    4. McGarry ME, Illek B, Ly NP, Zlock L, Olshansky S, Moreno C, Finkbeiner WE, Nielson DW. In vivo and in vitro ivacaftor response in cystic fibrosis patients with residual CFTR function: N-of-1 studies. Pediatr Pulmonol. 2017 Apr; 52(4):472-479. PMID: 28068001.
      View in: PubMed
    5. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. J Biol Chem. 2017 01 20; 292(3):771-785. PMID: 27895116.
      View in: PubMed
    6. Boecking CA, Drey EA, Kerns JL, Finkbeiner WE. Correlation of Prenatal Diagnosis and Pathology Findings Following Dilation and Evacuation for Fetal Anomalies. Arch Pathol Lab Med. 2017 Feb; 141(2):267-273. PMID: 27763778.
      View in: PubMed
    7. Zhang L, Gallup M, Zlock L, Feeling Chen YT, Finkbeiner WE, McNamara NA. Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin. Am J Pathol. 2016 Dec; 186(12):3146-3159. PMID: 27765636.
      View in: PubMed
    8. Bonser LR, Zlock L, Finkbeiner W, Erle DJ. Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma. J Clin Invest. 2016 Jun 01; 126(6):2367-71. PMID: 27183390; PMCID: PMC4887179.
    9. Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J. 2016 06; 30(6):2187-97. PMID: 26932931; PMCID: PMC4871793 [Available on 06/01/17].
    10. Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS. Potentiators of Defective ?F508-CFTR Gating that Do Not Interfere with Corrector Action. Mol Pharmacol. 2015 Oct; 88(4):791-9. PMID: 26245207; PMCID: PMC4576684 [Available on 10/01/16].
    11. Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL. Some gating potentiators, including VX-770, diminish ?F508-CFTR functional expression. Sci Transl Med. 2014 Jul 23; 6(246):246ra97. PMID: 25101887; PMCID: PMC4467693.
    12. Zhang L, Gallup M, Zlock L, Chen YT, Finkbeiner WE, McNamara NA. Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro. J Pathol. 2014 Sep; 234(1):60-73. PMID: 24838315; PMCID: PMC4138268.
    13. Herring MJ, Putney LF, Wyatt G, Finkbeiner WE, Hyde DM. Growth of alveoli during postnatal development in humans based on stereological estimation. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15; 307(4):L338-44. PMID: 24907055.
      View in: PubMed
    14. Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV. Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1005-7. PMID: 24735037; PMCID: PMC4098098.
    15. Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS. Synergy-based small-molecule screen using a human lung epithelial cell line yields ?F508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul; 86(1):42-51. PMID: 24737137; PMCID: PMC4054004.
    16. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia. FASEB J. 2014 Feb; 28(2):791-801. PMID: 24200884; PMCID: PMC3898646.
    17. Hajighasemi-Ossareh M, Borthwell RM, Lachowicz-Scroggins M, Stevens JE, Finkbeiner WE, Widdicombe JH. Distribution and size of mucous glands in the ferret tracheobronchial tree. Anat Rec (Hoboken). 2013 Nov; 296(11):1768-74. PMID: 24106034; PMCID: PMC4096109.
    18. Zhang L, Gallup M, Zlock L, Finkbeiner WE, McNamara NA. Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways. Am J Pathol. 2013 Jun; 182(6):1986-95. PMID: 23562274.
      View in: PubMed
    19. Zhang L, Gallup M, Zlock L, Basbaum C, Finkbeiner WE, McNamara NA. Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1. J Pathol. 2013 Jan; 229(1):74-86. PMID: 22833523; PMCID: PMC4096852.
    20. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. PMID: 22988107; PMCID: PMC3479591.
    21. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74. PMID: 22955319; PMCID: PMC3530212.
    22. Zhang L, Gallup M, Zlock L, Finkbeiner W, McNamara NA. p120-catenin modulates airway epithelial cell migration induced by cigarette smoke. Biochem Biophys Res Commun. 2012 Jan 06; 417(1):49-55. PMID: 22120634; PMCID: PMC4066870.
    23. Namkung W, Yao Z, Finkbeiner WE, Verkman AS. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 2011 Nov; 25(11):4048-62. PMID: 21836025; PMCID: PMC3205834.
    24. Finkbeiner WE, Zlock LT, Morikawa M, Lao AY, Dasari V, Widdicombe JH. Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L402-14. PMID: 21724859; PMCID: PMC3191753.
    25. Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS. Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB J. 2011 Jul; 25(7):2325-32. PMID: 21427214; PMCID: PMC3114535.
    26. Fischer H, Illek B, Sachs L, Finkbeiner WE, Widdicombe JH. CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L585-94. PMID: 20675434; PMCID: PMC2957417.
    27. Chen YT, Gallup M, Nikulina K, Lazarev S, Zlock L, Finkbeiner W, McNamara N. Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells. Am J Pathol. 2010 Sep; 177(3):1255-64. PMID: 20651243; PMCID: PMC2928959.
    28. Namkung W, Finkbeiner WE, Verkman AS. CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures. Mol Biol Cell. 2010 Aug 01; 21(15):2639-48. PMID: 20554763; PMCID: PMC2912350.
    29. Lachowicz-Scroggins ME, Boushey HA, Finkbeiner WE, Widdicombe JH. Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection. Am J Respir Cell Mol Biol. 2010 Dec; 43(6):652-61. PMID: 20081054; PMCID: PMC2993086.
    30. Finkbeiner WE, Zlock LT, Mehdi I, Widdicombe JH. Cultures of human tracheal gland cells of mucous or serous phenotype. In Vitro Cell Dev Biol Anim. 2010 May; 46(5):450-6. PMID: 19998060; PMCID: PMC2862963.
    31. Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2010 Feb 12; 285(7):4278-90. PMID: 19996317; PMCID: PMC2836032.
    32. Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS. Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1131-40. PMID: 19820035.
      View in: PubMed
    33. Lopez-Souza N, Favoreto S, Wong H, Ward T, Yagi S, Schnurr D, Finkbeiner WE, Dolganov GM, Widdicombe JH, Boushey HA, Avila PC. In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. J Allergy Clin Immunol. 2009 Jun; 123(6):1384-90.e2. PMID: 19428098; PMCID: PMC2744461.
    34. Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS. In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye. J Biol Chem. 2009 Jun 05; 284(23):15916-26. PMID: 19364771; PMCID: PMC2708887.
    35. Avdalovic M, Putney L, Tyler N, Finkbeiner W, Pinkerton K, Hyde D. In utero and postnatal exposure to environmental tobacco smoke (ETS) alters alveolar and respiratory bronchiole (RB) growth and development in infant monkeys. Toxicol Pathol. 2009 Feb; 37(2):256-63. PMID: 19332666.
      View in: PubMed
    36. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. PMID: 17965775; PMCID: PMC2040320.
    37. Fischer H, Illek B, Finkbeiner WE, Widdicombe JH. Basolateral Cl channels in primary airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1432-43. PMID: 17322286.
      View in: PubMed
    38. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C. Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One. 2006 Dec 20; 1:e93. PMID: 17183725; PMCID: PMC1762353.
    39. Araya J, Cambier S, Morris A, Finkbeiner W, Nishimura SL. Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am J Pathol. 2006 Aug; 169(2):405-15. PMID: 16877343; PMCID: PMC1698780.
    40. Levin MH, Sullivan S, Nielson D, Yang B, Finkbeiner WE, Verkman AS. Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins. J Biol Chem. 2006 Sep 01; 281(35):25803-12. PMID: 16829520.
      View in: PubMed
    41. Widdicombe JH, Sachs LA, Morrow JL, Finkbeiner WE. Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function. Biotechniques. 2005 Aug; 39(2):249-55. PMID: 16116798.
      View in: PubMed
    42. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. PMID: 15596485.
      View in: PubMed
    43. Carlson JR, Li L, Helton CL, Munn RJ, Wasson K, Perez RV, Gallay BJ, Finkbeiner WE. Disseminated microsporidiosis in a pancreas/kidney transplant recipient. Arch Pathol Lab Med. 2004 Mar; 128(3):e41-3. PMID: 14987135.
      View in: PubMed
    44. Di YP, Harper R, Zhao Y, Pahlavan N, Finkbeiner W, Wu R. Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts. J Biol Chem. 2003 Jan 10; 278(2):1165-73. PMID: 12409287.
      View in: PubMed