Christian Diederich, PhD

Title(s)Professor, Radiation Oncology
SchoolSchool of Medicine
Address2340 Sutter Street, #S331
San Francisco CA 94115
ORCID ORCID Icon0000-0002-7260-6226 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Euorpean Society of Hyperthermic Oncology2022ESHO - Pyrexar Award
    American Association of Physicists in Medicine (AAPM)2019Fellow
    Society for Thermal Medicine (STM)2019George M. Hahn Award
    Society for Thermal Medicine (STM)2010J. Eugene Robinson Award
    North American Hyperthermia Society (now STM)2001  - 2002President

    Collapse Overview 
    Collapse Overview
    As a Professor in the Radiation Oncology department at UCSF, my research interests revolve around hyperthermia, thermal therapy, HIFU (high-intensity focused ultrasound), ultrasound, and image guidance. I have authored numerous research publications, covering topics such as motion-robust MR thermometry, ultrasound applicators for therapeutic ultrasound, MR-guided thermal therapy, and ultrasound-based treatment of various malignancies.

    My contributions to the field have been recognized with several prestigious awards and honors, including the ESHO - Pyrexar Award from the European Society of Hyperthermic Oncology and being named a Fellow of the American Association of Physicists in Medicine. I have also served as the President of the North American Hyperthermia Society.

    Throughout my career, I have been actively involved in leading research projects sponsored by the NIH, focusing on image-guided ultrasound ablation for precision targeting of prostate cancer, deployable ultrasound applicators for MRI-guided thermal therapy of pancreatic cancer, and methods for precise MR-guided hyperthermia delivery for targeted cancer therapies. Additionally, I have undertaken projects involving minimally-invasive catheter-based ultrasound for tumor ablation in the lung and non-thermal pulsed FUS (focused ultrasound) for the treatment of intervertebral disc degeneration.

    In summary, my work as a Professor in Radiation Oncology at UCSF centers on advancing the field of thermal therapy, ultrasound-based treatments, and image-guided interventions for cancer and other medical conditions, with a strong emphasis on precision and innovation.

    Collapse Research 
    Collapse Research Activities and Funding
    Minimally-Invasive Catheter-based Ultrasound for Precision Tumor Ablation in Lung
    NIH NCI R43CA236065Apr 1, 2019 - Mar 31, 2021
    Role: M-PI
    Development of Methods for Precise MR-guided Hyperthermia Delivery for Targeted Cancer Therapies
    NIH R21EB026018Feb 1, 2019 - Dec 31, 2021
    Role: Co-Investigator
    Deployable Endoluminal Ultrasound Phased Array for Precision Treatment of Pancreatic Cancer
    NIH/NCI R21CA230120Sep 1, 2018 - Aug 31, 2021
    Role: PI
    Image-guided ultrasound ablation for precision targeting of prostate cancer
    NIH/NCI R01CA230323Aug 1, 2018 - Jul 31, 2024
    Role: M-PI
    Deployable Ultrasound Applicators for MRI Guided Thermal Therapy of Pancreatic Cancer
    NIH R01EB025990Jul 1, 2018 - Mar 31, 2024
    Role: PI
    Non-Thermal Pulsed FUS for Treatment of Intervertebral Disc Degeneration
    NIH R21EB024347Apr 1, 2017 - Jan 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Motion-robust, multi-slice, real-time MR thermometry for MR-guided thermal therapy in abdominal organs. Int J Hyperthermia. 2023; 40(1):2151649. Kim K, Diederich C, Narsinh K, Ozhinsky E. PMID: 36535967; PMCID: PMC10269483.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. An endoluminal cylindrical sectored-ring ultrasound phased-array applicator for minimally-invasive therapeutic ultrasound. Med Phys. 2023 Jan; 50(1):1-19. Zubair M, Adams MS, Diederich CJ. PMID: 36413363; PMCID: PMC9870260.
      View in: PubMed   Mentions: 1     Fields:    
    3. Technical note: Low-cost MR-compatible pneumatic respiratory organ motion simulator for the development of MR-guided thermal therapy. Med Phys. 2022 Jul; 49(7):4365-4371. Kim K, Jones P, Diederich C, Ozhinsky E. PMID: 35635215; PMCID: PMC9288488.
      View in: PubMed   Mentions: 1     Fields:    
    4. High Contrast Ultrasonic Method With Multi-Spatiotemporal Compounding for Monitoring Catheter-Based Ultrasound Thermal Therapy: Development and Ex Vivo Evaluations. IEEE Trans Biomed Eng. 2021 10; 68(10):3131-3141. Wang D, Adams MS, Jones PD, Liu D, Burdette EC, Diederich CJ. PMID: 33755552; PMCID: PMC8489743.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Deployable ultrasound applicators for endoluminal delivery of volumetric hyperthermia. Int J Hyperthermia. 2021 08 10; 38(1):1188-1204. Zubair M, Adams MS, Diederich CJ. PMID: 34376103; PMCID: PMC8802621.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. AAPM Task Group 241: A medical physicist's guide to MRI-guided focused ultrasound body systems. Med Phys. 2021 Sep; 48(9):e772-e806. Payne A, Chopra R, Ellens N, Chen L, Ghanouni P, Sammet S, Diederich C, Ter Haar G, Parker D, Moonen C, Stafford J, Moros E, Schlesinger D, Benedict S, Wear K, Partanen A, Farahani K. PMID: 34224149.
      View in: PubMed   Mentions: 2     Fields:    
    7. Sonication strategies toward volumetric ultrasound hyperthermia treatment using the ExAblate body MRgFUS system. Int J Hyperthermia. 2021; 38(1):1590-1600. Kim K, Zubair M, Adams M, Diederich CJ, Ozhinsky E. PMID: 34749579; PMCID: PMC8806831.
      View in: PubMed   Mentions: 2     Fields:    
    8. Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint. Int J Hyperthermia. 2021; 38(1):130-135. Zhang W, Trivedi H, Adams M, Losey AD, Diederich CJ, Ozhinsky E, Rieke V, Bucknor MD. PMID: 33541151.
      View in: PubMed   Mentions: 1     Fields:    
    9. In silico feasibility assessment of extracorporeal delivery of low-intensity pulsed ultrasound to intervertebral discs within the lumbar spine. Phys Med Biol. 2020 11 05; 65(21):215011. Adams MS, Lotz JC, Diederich CJ. PMID: 32620003.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Microbubble-Facilitated Ultrasound Catheter Ablation Causes Microvascular Damage and Fibrosis. Ultrasound Med Biol. 2021 01; 47(1):131-138. Nazer B, Giraud D, Zhao Y, Qi Y, Mason O, Jones PD, Diederich CJ, Gerstenfeld EP, Lindner JR. PMID: 33092899; PMCID: PMC8211318.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    11. In vivo Nakagami-m parametric imaging of microbubble-enhanced ultrasound regulated by RF and VF processing techniques. Med Phys. 2020 Nov; 47(11):5659-5668. Wang D, Liu D, Sang Y, Zhang Y, Wan M, Diederich CJ. PMID: 32965033.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. LIPUS far-field exposimetry system for uniform stimulation of tissues in-vitro: development and validation with bovine intervertebral disc cells. Biomed Phys Eng Express. 2020 05 06; 6(3):035033. Horne DA, Jones PD, Adams MS, Lotz JC, Diederich CJ. PMID: 33438678.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Dual-sectored transurethral ultrasound for thermal treatment of stress urinary incontinence: in silico studies in 3D anatomical models. Med Biol Eng Comput. 2020 Jun; 58(6):1325-1340. Liu D, Adams M, Burdette EC, Diederich CJ. PMID: 32277340; PMCID: PMC7285893.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Deployable cylindrical phased-array applicator mimicking a concentric-ring configuration for minimally-invasive delivery of therapeutic ultrasound. Phys Med Biol. 2019 06 10; 64(12):125001. Adams MS, Diederich CJ. PMID: 31108478; PMCID: PMC6658172.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Quality assurance guidelines for interstitial hyperthermia. Int J Hyperthermia. 2019; 36(1):277-294. Dobšícek Trefná H, Schmidt M, van Rhoon GC, Kok HP, Gordeyev SS, Lamprecht U, Marder D, Nadobny J, Ghadjar P, Abdel-Rahman S, Kukielka AM, Strnad V, Hurwitz MD, Vujaskovic Z, Diederich CJ, Stauffer PR, Crezee J. PMID: 30676101.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    16. Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound. J Neuropathol Exp Neurol. 2019 01 01; 78(1):47-56. Yao X, Adams MS, Jones PD, Diederich CJ, Verkman AS. PMID: 30500945; PMCID: PMC6657442.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    17. Endobronchial high-intensity ultrasound for thermal therapy of pulmonary malignancies: simulations with patient-specific lung models. Int J Hyperthermia. 2019; 36(1):1108-1121. Liu D, Adams MS, Diederich CJ. PMID: 31726895.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. 880 kHz ultrasound treatment for drug delivery to the vitreous humor. Am J Transl Res. 2018; 10(10):3162-3170. Lamy R, Chan E, Lee OT, Phone A, Salgaonkar VA, Diederich CJ, Stewart JM. PMID: 30416658; PMCID: PMC6220232.
      View in: PubMed   Mentions: 3  
    19. MR thermometry-guided ultrasound hyperthermia of user-defined regions using the ExAblate prostate ablation array. J Ther Ultrasound. 2018; 6:7. Ozhinsky E, Salgaonkar VA, Diederich CJ, Rieke V. PMID: 30123506; PMCID: PMC6088423.
      View in: PubMed   Mentions: 10  
    20. Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion. NMR Biomed. 2019 10; 32(10):e3962. Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J. PMID: 30022550; PMCID: PMC6338537.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    21. Transurethral high-intensity ultrasound for treatment of stress urinary incontinence (SUI): simulation studies with patient-specific models. Int J Hyperthermia. 2018 12; 34(8):1236-1247. Liu D, Adams MS, Burdette EC, Diederich CJ. PMID: 29566562; PMCID: PMC6136964.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. A minimally invasive catheter-based ultrasound technology for therapeutic interventions in brain: initial preclinical studies. Neurosurg Focus. 2018 02; 44(2):E13. Ghoshal G, Gee L, Heffter T, Williams E, Bromfield C, Rund L, Ehrhardt JM, Diederich CJ, Fischer GS, Pilitsis JG, Burdette EC. PMID: 29385920; PMCID: PMC5891098.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. Integration of deployable fluid lenses and reflectors with endoluminal therapeutic ultrasound applicators: Preliminary investigations of enhanced penetration depth and focal gain. Med Phys. 2017 Oct; 44(10):5339-5356. Adams MS, Salgaonkar VA, Scott SJ, Sommer G, Diederich CJ. PMID: 28681404; PMCID: PMC5646230.
      View in: PubMed   Mentions: 4     Fields:    
    24. Theoretical investigation of transgastric and intraductal approaches for ultrasound-based thermal therapy of the pancreas. J Ther Ultrasound. 2017; 5:10. Scott SJ, Adams MS, Salgaonkar V, Sommer FG, Diederich CJ. PMID: 28469915; PMCID: PMC5414307.
      View in: PubMed   Mentions: 1  
    25. Quality assurance guidelines for superficial hyperthermia clinical trials : II. Technical requirements for heating devices. Strahlenther Onkol. 2017 May; 193(5):351-366. Dobšícek Trefná H, Crezee J, Schmidt M, Marder D, Lamprecht U, Ehmann M, Nadobny J, Hartmann J, Lomax N, Abdel-Rahman S, Curto S, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, Van Rhoon GC. PMID: 28251250; PMCID: PMC5405104.
      View in: PubMed   Mentions: 17     Fields:    
    26. Low intensity pulsed ultrasound (LIPUS) for the treatment of intervertebral disc degeneration. Proc SPIE Int Soc Opt Eng. 2017 Jan-Feb; 10066. Horne D, Jones P, Salgaonkar V, Adams M, Ozilgen BA, Zahos P, Tang X, Liebenburg E, Coughlin D, Lotz J, Diederich C. PMID: 29104343; PMCID: PMC5667559.
      View in: PubMed   Mentions:
    27. Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirements. Int J Hyperthermia. 2017 Jun; 33(4):471-482. Trefná HD, Crezee H, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J, Nadobny J, Gellermann J, van Holthe N, Ghadjar P, Lomax N, Abdel-Rahman S, Bert C, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, van Rhoon GC. PMID: 28049386.
      View in: PubMed   Mentions: 24     Fields:    
    28. Endoluminal ultrasound applicators for MR-guided thermal ablation of pancreatic tumors: Preliminary design and evaluation in a porcine pancreas model. Med Phys. 2016 Jul; 43(7):4184. Adams MS, Salgaonkar VA, Plata-Camargo J, Jones PD, Pascal-Tenorio A, Chen HY, Bouley DM, Sommer G, Pauly KB, Diederich CJ. PMID: 27370138; PMCID: PMC4912561.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    29. Clinical applications of custom-made vaginal cylinders constructed using three-dimensional printing technology. J Contemp Brachytherapy. 2016 Jun; 8(3):208-14. Sethi R, Cunha A, Mellis K, Siauw T, Diederich C, Pouliot J, Hsu IC. PMID: 27504130; PMCID: PMC4965501.
      View in: PubMed   Mentions: 27  
    30. Thermal therapy of pancreatic tumours using endoluminal ultrasound: Parametric and patient-specific modelling. Int J Hyperthermia. 2016; 32(2):97-111. Adams MS, Scott SJ, Salgaonkar VA, Sommer G, Diederich CJ. PMID: 27097663; PMCID: PMC4928681.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Epicardial Catheter Ablation Using High-Intensity Ultrasound: Validation in a Swine Model. Circ Arrhythm Electrophysiol. 2015 Dec; 8(6):1491-7. Nazer B, Salgaonkar V, Diederich CJ, Jones PD, Duggirala S, Tanaka Y, Ng B, Sievers R, Gerstenfeld EP. PMID: 26546345.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    32. Quantifying temperature-dependent T1 changes in cortical bone using ultrashort echo-time MRI. Magn Reson Med. 2015 Dec; 74(6):1548-55. Han M, Rieke V, Scott SJ, Ozhinsky E, Salgaonkar VA, Jones PD, Larson PE, Diederich CJ, Krug R. PMID: 26390357; PMCID: PMC4715675.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    33. A feasibility study on monitoring the evolution of apparent diffusion coefficient decrease during thermal ablation. Med Phys. 2015 Sep; 42(9):5130-7. Plata JC, Holbrook AB, Marx M, Salgaonkar V, Jones P, Pascal-Tenorio A, Bouley D, Diederich C, Sommer G, Pauly KB. PMID: 26328964; PMCID: PMC4537482.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Catheter-based ultrasound technology for image-guided thermal therapy: current technology and applications. Int J Hyperthermia. 2015 Mar; 31(2):203-15. Salgaonkar VA, Diederich CJ. PMID: 25799287; PMCID: PMC4659534.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Development of an endoluminal high-intensity ultrasound applicator for image-guided thermal therapy of pancreatic tumors. Proc SPIE Int Soc Opt Eng. 2015 Feb 07; 9326. Adams MS, Scott SJ, Salgaonkar VA, Jones PD, Plata-Camargo JC, Sommer G, Diederich CJ. PMID: 26677314; PMCID: PMC4677833.
      View in: PubMed   Mentions: 1  
    36. Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. Int J Hyperthermia. 2014 Aug; 30(5):285-94. Zagar TM, Vujaskovic Z, Formenti S, Rugo H, Muggia F, O'Connor B, Myerson R, Stauffer P, Hsu IC, Diederich C, Straube W, Boss MK, Boico A, Craciunescu O, Maccarini P, Needham D, Borys N, Blackwell KL, Dewhirst MW. PMID: 25144817; PMCID: PMC4162656.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    37. Interstitial ultrasound ablation of vertebral and paraspinal tumours: parametric and patient-specific simulations. Int J Hyperthermia. 2014 Jun; 30(4):228-44. Scott SJ, Salgaonkar V, Prakash P, Burdette EC, Diederich CJ. PMID: 25017322; PMCID: PMC4696406.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Model-based feasibility assessment and evaluation of prostate hyperthermia with a commercial MR-guided endorectal HIFU ablation array. Med Phys. 2014 Mar; 41(3):033301. Salgaonkar VA, Prakash P, Rieke V, Ozhinsky E, Plata J, Kurhanewicz J, Hsu IC, Diederich CJ. PMID: 24593742; PMCID: PMC3987720.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    39. Components of a hyperthermia clinic: recommendations for staffing, equipment, and treatment monitoring. Int J Hyperthermia. 2014 Feb; 30(1):1-5. Myerson RJ, Moros EG, Diederich CJ, Haemmerich D, Hurwitz MD, Hsu IC, McGough RJ, Nau WH, Straube WL, Turner PF, Vujaskovic Z, Stauffer PR. PMID: 24350642.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    40. Approaches for modelling interstitial ultrasound ablation of tumours within or adjacent to bone: theoretical and experimental evaluations. Int J Hyperthermia. 2013 Nov; 29(7):629-42. Scott SJ, Prakash P, Salgaonkar V, Jones PD, Cam RN, Han M, Rieke V, Burdette EC, Diederich CJ. PMID: 24102393; PMCID: PMC4026292.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    41. Ultrasound-enhanced penetration of topical riboflavin into the corneal stroma. Invest Ophthalmol Vis Sci. 2013 Aug 28; 54(8):5908-12. Lamy R, Chan E, Zhang H, Salgaonkar VA, Good SD, Porco TC, Diederich CJ, Stewart JM. PMID: 23920369; PMCID: PMC3757909.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    42. MR-guided focused ultrasound surgery, present and future. Med Phys. 2013 Aug; 40(8):080901. Schlesinger D, Benedict S, Diederich C, Gedroyc W, Klibanov A, Larner J. PMID: 23927296; PMCID: PMC3724793.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    43. Modelling of endoluminal and interstitial ultrasound hyperthermia and thermal ablation: applications for device design, feedback control and treatment planning. Int J Hyperthermia. 2013 Jun; 29(4):296-307. Prakash P, Salgaonkar VA, Diederich CJ. PMID: 23738697; PMCID: PMC4087028.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    44. Applicators for magnetic resonance-guided ultrasonic ablation of benign prostatic hyperplasia. Invest Radiol. 2013 Jun; 48(6):387-94. Sommer G, Pauly KB, Holbrook A, Plata J, Daniel B, Bouley D, Gill H, Prakash P, Salgaonkar V, Jones P, Diederich C. PMID: 23462673; PMCID: PMC4045500.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    45. Simulation techniques in hyperthermia treatment planning. Int J Hyperthermia. 2013 Jun; 29(4):346-57. Paulides MM, Stauffer PR, Neufeld E, Maccarini PF, Kyriakou A, Canters RA, Diederich CJ, Bakker JF, Van Rhoon GC. PMID: 23672453; PMCID: PMC3711016.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    46. Focal ablation of prostate cancer: four roles for magnetic resonance imaging guidance. Can J Urol. 2013 Apr; 20(2):6672-81. Sommer G, Bouley D, Gill H, Daniel B, Pauly KB, Diederich C. PMID: 23587506; PMCID: PMC4045501.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    47. MR guided thermal therapy of pancreatic tumors with endoluminal, intraluminal and interstitial catheter-based ultrasound devices: Preliminary theoretical and experimental investigations. Proc SPIE Int Soc Opt Eng. 2013 Feb 26; 8584:85840V. Prakash P, Salgaonkar VA, Scott SJ, Jones P, Hensley D, Holbrook A, Plata J, Sommer G, Diederich CJ. PMID: 24860246; PMCID: PMC4031683.
      View in: PubMed   Mentions: 3  
    48. Multiple applicator hepatic ablation with interstitial ultrasound devices: theoretical and experimental investigation. Med Phys. 2012 Dec; 39(12):7338-49. Prakash P, Salgaonkar VA, Clif Burdette E, Diederich CJ. PMID: 23231283; PMCID: PMC3523641.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    49. Considerations for theoretical modelling of thermal ablation with catheter-based ultrasonic sources: implications for treatment planning, monitoring and control. Int J Hyperthermia. 2012; 28(1):69-86. Prakash P, Diederich CJ. PMID: 22235787; PMCID: PMC3366914.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    50. Temperature superposition for fast computation of 3D temperature distributions during optimization and planning of interstitial ultrasound hyperthermia treatments. Int J Hyperthermia. 2012; 28(3):235-49. Salgaonkar VA, Prakash P, Diederich CJ. PMID: 22515345; PMCID: PMC4659707.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    51. Implant strategies for endocervical and interstitial ultrasound hyperthermia adjunct to HDR brachytherapy for the treatment of cervical cancer. Phys Med Biol. 2011 Jul 07; 56(13):3967-84. Wootton JH, Prakash P, Hsu IC, Diederich CJ. PMID: 21666290.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    52. Catheter-based ultrasound hyperthermia with HDR brachytherapy for treatment of locally advanced cancer of the prostate and cervix. Proc SPIE Int Soc Opt Eng. 2011 Feb 22; 7901:79010O. Diederich CJ, Wootton J, Prakash P, Salgaonkar V, Juang T, Scott S, Chen X, Cunha A, Pouliot J, Hsu IC. PMID: 25076820; PMCID: PMC4112774.
      View in: PubMed   Mentions: 12  
    53. Endocervical ultrasound applicator for integrated hyperthermia and HDR brachytherapy in the treatment of locally advanced cervical carcinoma. Med Phys. 2011 Feb; 38(2):598-611. Wootton JH, Hsu IC, Diederich CJ. PMID: 21452697; PMCID: PMC3033875.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    54. Percutaneous computed tomography fluoroscopy-guided conformal ultrasonic ablation of vertebral tumors in a rabbit tumor model. Laboratory investigation. J Neurosurg Spine. 2010 Dec; 13(6):773-9. Sciubba DM, Burdette EC, Cheng JJ, Pennant WA, Noggle JC, Petteys RJ, Alix C, Diederich CJ, Fichtinger G, Gokaslan ZL, Murphy KP. PMID: 21121752.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    55. Optimisation-based thermal treatment planning for catheter-based ultrasound hyperthermia. Int J Hyperthermia. 2010 Feb; 26(1):39-55. Chen X, Diederich CJ, Wootton JH, Pouliot J, Hsu IC. PMID: 20100052.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    56. Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence. Int J Hyperthermia. 2010; 26(7):686-98. Stauffer PR, Maccarini P, Arunachalam K, Craciunescu O, Diederich C, Juang T, Rossetto F, Schlorff J, Milligan A, Hsu J, Sneed P, Vujaskovic Z. PMID: 20849262; PMCID: PMC3055270.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    57. Hyperthermia classic commentary: 'Arrhenius relationships from the molecule and cell to the clinic' by William Dewey, Int. J. Hyperthermia, 10:457-483, 1994. Int J Hyperthermia. 2009 Feb; 25(1):21-4. Dewey WC, Diederich CJ, Dewhirst MW. PMID: 19219696.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    58. Monitoring prostate thermal therapy with diffusion-weighted MRI. Magn Reson Med. 2008 Jun; 59(6):1365-72. Chen J, Daniel BL, Diederich CJ, Bouley DM, van den Bosch MA, Kinsey AM, Sommer G, Pauly KB. PMID: 18506801.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    59. Transurethral ultrasound applicators with dynamic multi-sector control for prostate thermal therapy: in vivo evaluation under MR guidance. Med Phys. 2008 May; 35(5):2081-93. Kinsey AM, Diederich CJ, Rieke V, Nau WH, Pauly KB, Bouley D, Sommer G. PMID: 18561684; PMCID: PMC2673638.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    60. Catheter-based ultrasound devices and MR thermal monitoring for conformal prostate thermal therapy. Annu Int Conf IEEE Eng Med Biol Soc. 2008; 2008:3664-8. Diederich CJ, Nau WH, Kinsey A, Ross T, Wootton J, Juang T, Butts-Pauly K, Rieke V, Chen J, Bouley DM, Sommer G. PMID: 19163505.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    61. Prostate thermal therapy with high intensity transurethral ultrasound: the impact of pelvic bone heating on treatment delivery. Int J Hyperthermia. 2007 Dec; 23(8):609-22. Wootton JH, Ross AB, Diederich CJ. PMID: 18097849.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    62. Society of Thermal Medicine Robinson Award 2007. Int J Hyperthermia. 2007 Aug; 23(5):473-4. Diederich CJ. PMID: 17701539.
      View in: PubMed   Mentions:    Fields:    
    63. Referenceless MR thermometry for monitoring thermal ablation in the prostate. IEEE Trans Med Imaging. 2007 Jun; 26(6):813-21. Rieke V, Kinsey AM, Ross AB, Nau WH, Diederich CJ, Sommer G, Pauly KB. PMID: 17679332; PMCID: PMC2780365.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    64. Intradiscal thermal therapy using interstitial ultrasound: an in vivo investigation in ovine cervical spine. Spine (Phila Pa 1976). 2007 Mar 01; 32(5):503-11. Nau WH, Diederich CJ, Shu R, Kinsey A, Bass E, Lotz J, Hu S, Simko J, Ferrier W, Sutton J, Attawia M, Pellegrino R. PMID: 17334283.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    65. Ultrasound interstitial thermal therapy (USITT) for the treatment of uterine myomas. Proc SPIE Int Soc Opt Eng. 2007 Feb 09; 6440:64400F. Nau WH, Diederich CJ, Simko J, Juang T, Jacoby A, Burdette EC. PMID: 25076819; PMCID: PMC4112769.
      View in: PubMed   Mentions: 4  
    66. Correlation of contrast-enhanced MR images with the histopathology of minimally invasive thermal and cryoablation cancer treatments in normal dog prostates. Proc SPIE Int Soc Opt Eng. 2007 Feb 08; 6440:644006. Bouley DM, Daniel B, Pauly KB, Liu E, Kinsey A, Nau W, Diederich CJ, Sommer G. PMID: 25076818; PMCID: PMC4112763.
      View in: PubMed   Mentions: 4  
    67. Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Top Magn Reson Imaging. 2006 Jun; 17(3):195-207. Pauly KB, Diederich CJ, Rieke V, Bouley D, Chen J, Nau WH, Ross AB, Kinsey AM, Sommer G. PMID: 17414077.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    68. Multisectored interstitial ultrasound applicators for dynamic angular control of thermal therapy. Med Phys. 2006 May; 33(5):1352-63. Kinsey AM, Diederich CJ, Tyreus PD, Nau WH, Rieke V, Pauly KB. PMID: 16752571.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    69. Intradiscal thermal therapy does not stimulate biologic remodeling in an in vivo sheep model. Spine (Phila Pa 1976). 2006 Jan 15; 31(2):139-45. Bass EC, Nau WH, Diederich CJ, Liebenberg E, Shu R, Pellegrino R, Sutton J, Attawia M, Hu SS, Ferrier WT, Lotz JC. PMID: 16418631.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    70. Thermal ablation and high-temperature thermal therapy: overview of technology and clinical implementation. Int J Hyperthermia. 2005 Dec; 21(8):745-53. Diederich CJ. PMID: 16338857.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    71. Effects of spatial and temporal resolution for MR image-guided thermal ablation of prostate with transurethral ultrasound. J Magn Reson Imaging. 2005 Jul; 22(1):109-18. Pisani LJ, Ross AB, Diederich CJ, Nau WH, Sommer FG, Glover GH, Butts K. PMID: 15971190.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    72. Curvilinear transurethral ultrasound applicator for selective prostate thermal therapy. Med Phys. 2005 Jun; 32(6):1555-65. Ross AB, Diederich CJ, Nau WH, Rieke V, Butts RK, Sommer G, Gill H, Bouley DM. PMID: 16013714.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    73. Feasibility of using interstitial ultrasound for intradiscal thermal therapy: a study in human cadaver lumbar discs. Phys Med Biol. 2005 Jun 21; 50(12):2807-21. Nau WH, Diederich CJ, Shu R. PMID: 15930604.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    74. MRI-guided interstitial ultrasound thermal therapy of the prostate: a feasibility study in the canine model. Med Phys. 2005 Mar; 32(3):733-43. Nau WH, Diederich CJ, Ross AB, Butts K, Rieke V, Bouley DM, Gill H, Daniel B, Sommer G. PMID: 15839345.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    75. Catheter-based ultrasound applicators for selective thermal ablation: progress towards MRI-guided applications in prostate. Int J Hyperthermia. 2004 Nov; 20(7):739-56. Diederich CJ, Nau WH, Ross AB, Tyreus PD, Butts K, Rieke V, Sommer G. PMID: 15675669.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    76. Interleaved echo-planar imaging for fast multiplanar magnetic resonance temperature imaging of ultrasound thermal ablation therapy. J Magn Reson Imaging. 2004 Oct; 20(4):706-14. Stafford RJ, Price RE, Diederich CJ, Kangasniemi M, Olsson LE, Hazle JD. PMID: 15390144.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    77. Evaluation of temperature distributions in cadaveric lumbar spine during nucleoplasty. Phys Med Biol. 2004 Apr 21; 49(8):1583-94. Nau WH, Diederich CJ. PMID: 15152694.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    78. Two-dimensional acoustic attenuation mapping of high-temperature interstitial ultrasound lesions. Phys Med Biol. 2004 Feb 21; 49(4):533-46. Tyréus PD, Diederich C. PMID: 15005163.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    79. Transurethral ultrasound applicators with directional heating patterns for prostate thermal therapy: in vivo evaluation using magnetic resonance thermometry. Med Phys. 2004 Feb; 31(2):405-13. Diederich CJ, Stafford RJ, Nau WH, Burdette EC, Price RE, Hazle JD. PMID: 15000627.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    80. Highly directional transurethral ultrasound applicators with rotational control for MRI-guided prostatic thermal therapy. Phys Med Biol. 2004 Jan 21; 49(2):189-204. Ross AB, Diederich CJ, Nau WH, Gill H, Bouley DM, Daniel B, Rieke V, Butts RK, Sommer G. PMID: 15083666.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    81. Evaluation of endorectal and urethral cooling devices during MR-guided ultrasound thermal ablation in canine prostate. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2492-5. Nau WH, Diederich CJ, Ross AB, Rieke V, Butts K, Sommers G. PMID: 17270778.
      View in: PubMed   Mentions: 4     Fields:    
    82. Interstitial ultrasound applicators with dynamic angular control for thermal ablation of tumors under MR-guidance. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2496-9. Kinsey AM, Tyreus PD, Rieke V, Butts K, Nau WH, Sommer G, Diederich CJ. PMID: 17270779.
      View in: PubMed   Mentions: 2     Fields:    
    83. MRI-temperature mapping during ultrasound prostate ablation using fat for phase estimation. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2500-2. Rieke V, Ross AB, Nau WH, Diederich CJ, Sommer G, Butts K. PMID: 17270780.
      View in: PubMed   Mentions: 2     Fields:    
    84. Temperature and thermal dose distributions during intradiscal electrothermal therapy in the cadaveric lumbar spine. Spine (Phila Pa 1976). 2003 Aug 01; 28(15):1700-8; discussion 1709. Kleinstueck FS, Diederich CJ, Nau WH, Puttlitz CM, Smith JA, Bradford DS, Lotz JC. PMID: 12897495.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    85. Effect of applicator diameter on lesion size from high temperature interstitial ultrasound thermal therapy. Med Phys. 2003 Jul; 30(7):1855-63. Tyréus PD, Nau WH, Diederich CJ. PMID: 12906204.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    86. Multiplanar MR temperature-sensitive imaging of cerebral thermal treatment using interstitial ultrasound applicators in a canine model. J Magn Reson Imaging. 2002 Nov; 16(5):522-31. Kangasniemi M, Diederich CJ, Price RE, Stafford RJ, Schomer DF, Olsson LE, Tyreus PD, Nau WH, Hazle JD. PMID: 12412028.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    87. Theoretical model of internally cooled interstitial ultrasound applicators for thermal therapy. Phys Med Biol. 2002 Apr 07; 47(7):1073-89. Tyréus PD, Diederich CJ. PMID: 11996056.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    88. MRI-guided thermal therapy of transplanted tumors in the canine prostate using a directional transurethral ultrasound applicator. J Magn Reson Imaging. 2002 Apr; 15(4):409-17. Hazle JD, Diederich CJ, Kangasniemi M, Price RE, Olsson LE, Stafford RJ. PMID: 11948830.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    89. Evaluation of multielement catheter-cooled interstitial ultrasound applicators for high-temperature thermal therapy. Med Phys. 2001 Jul; 28(7):1525-34. Nau WH, Diederich CJ, Burdette EC. PMID: 11488586.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    90. Control of interstitial thermal coagulation: comparative evaluation of microwave and ultrasound applicators. Med Phys. 2001 Jan; 28(1):104-17. Deardorff DL, Diederich CJ, Nau WH. PMID: 11213915.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    91. Ultrasound applicators with internal water-cooling for high-powered interstitial thermal therapy. IEEE Trans Biomed Eng. 2000 Oct; 47(10):1356-65. Deardorff DL, Diederich CJ. PMID: 11059170.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    92. Combination of transurethral and interstitial ultrasound applicators for high-temperature prostate thermal therapy. Int J Hyperthermia. 2000 Sep-Oct; 16(5):385-403. Diederich CJ, Nau WH, Burdette EC, Bustany IS, Deardorff DL, Stauffer PR. PMID: 11001573.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    93. Thermal and SAR characterization of multielement dual concentric conductor microwave applicators for hyperthermia, a theoretical investigation. Med Phys. 2000 Apr; 27(4):745-53. Rossetto F, Diederich CJ, Stauffer PR. PMID: 10798697.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    94. Directional power deposition from direct-coupled and catheter-cooled interstitial ultrasound applicators. Int J Hyperthermia. 2000 Mar-Apr; 16(2):129-44. Nau WH, Diederich CJ, Stauffer PR. PMID: 10763742.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    95. Novel catheter technology for ablative cure of atrial fibrillation. J Interv Card Electrophysiol. 2000 Jan; 4 Suppl 1:127-39. Lesh MD, Guerra P, Roithinger FX, Goseki Y, Diederich C, Nau WH, Maguire M, Taylor K. PMID: 10590500.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    96. Axial control of thermal coagulation using a multi-element interstitial ultrasound applicator with internal cooling. IEEE Trans Ultrason Ferroelectr Freq Control. 2000; 47(1):170-8. Deardorff DL, Diederich CJ. PMID: 18238528.
      View in: PubMed   Mentions: 7     Fields:    
    97. An anatomic approach to prevention of atrial fibrillation: pulmonary vein isolation with through-the-balloon ultrasound ablation (TTB-USA). Thorac Cardiovasc Surg. 1999 Aug; 47 Suppl 3:347-51. Lesh MD, Diederich C, Guerra PG, Goseki Y, Sparks PB. PMID: 10520766.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    98. Ultrasound technology for hyperthermia. Ultrasound Med Biol. 1999 Jul; 25(6):871-87. Diederich CJ, Hynynen K. PMID: 10461714.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    99. Angular directivity of thermal coagulation using air-cooled direct-coupled interstitial ultrasound applicators. Ultrasound Med Biol. 1999 May; 25(4):609-22. Deardorff DL, Diederich CJ. PMID: 10386737.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    100. Ultrasound applicators for interstitial thermal coagulation. IEEE Trans Ultrason Ferroelectr Freq Control. 1999; 46(5):1218-28. Diederich CJ, Nau WH, Stauffer PR. PMID: 18244315.
      View in: PubMed   Mentions: 8     Fields:    
    101. Air-cooling of direct-coupled ultrasound applicators for interstitial hyperthermia and thermal coagulation. Med Phys. 1998 Dec; 25(12):2400-9. Deardorff DL, Diederich CJ, Nau WH. PMID: 9874834.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    102. Effect of practical layered dielectric loads on SAR patterns from dual concentric conductor microstrip antennas. Int J Hyperthermia. 1998 Nov-Dec; 14(6):553-71. Rossetto F, Stauffer PR, Manfrini V, Diederich CJ, Biffi Gentili G. PMID: 9886662.
      View in: PubMed   Mentions: 4     Fields:    
    103. Minimax optimization-based inverse treatment planning for interstitial thermal therapy. Int J Hyperthermia. 1998 Jul-Aug; 14(4):347-66. Khalil-Bustany IS, Diederich CJ, Polak E, Kirjner-Neto C. PMID: 9690148.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    104. Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 1998 Jan 15; 40(2):287-95. Sneed PK, Stauffer PR, McDermott MW, Diederich CJ, Lamborn KR, Prados MD, Chang S, Weaver KA, Spry L, Malec MK, Lamb SA, Voss B, Davis RL, Wara WM, Larson DA, Phillips TL, Gutin PH. PMID: 9457811.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCTClinical Trials
    105. Direct-coupled interstitial ultrasound applicators for simultaneous thermobrachytherapy: a feasibility study. Int J Hyperthermia. 1996 May-Jun; 12(3):401-19. Diederich CJ, Khalil IS, Stauffer PR, Sneed PK, Phillips TL. PMID: 9044908.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    106. Ultrasound applicators with integrated catheter-cooling for interstitial hyperthermia: theory and preliminary experiments. Int J Hyperthermia. 1996 Mar-Apr; 12(2):279-97; discussion 299-300. Diederich CJ. PMID: 8926395.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    107. Interstitial ultrasound applicators are practical from an engineering perspective for treating large tumours. Int J Hyperthermia. 1996 Mar-Apr; 12(2):305-6. Diederich CJ. PMID: 8926398.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    108. An improved bolus configuration for commercial multielement ultrasound and microwave hyperthermia systems. Med Phys. 1994 Sep; 21(9):1401-3. Diederich CJ, Stauffer PR, Bozzo D. PMID: 7838050.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    109. Pre-clinical evaluation of a microwave planar array applicator for superficial hyperthermia. Int J Hyperthermia. 1993 Mar-Apr; 9(2):227-46. Diederich CJ, Stauffer PR. PMID: 8468507.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    110. The feasibility of using electrically focused ultrasound arrays to induce deep hyperthermia via body cavities. IEEE Trans Ultrason Ferroelectr Freq Control. 1991; 38(3):207-19. Diederich CJ, Hynynen K. PMID: 18267577.
      View in: PubMed   Mentions: 6     Fields:    
    111. The development of intracavitary ultrasonic applicators for hyperthermia: a design and experimental study. Med Phys. 1990 Jul-Aug; 17(4):626-34. Diederich CJ, Hynynen K. PMID: 2215407.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    112. Induction of hyperthermia using an intracavitary multielement ultrasonic applicator. IEEE Trans Biomed Eng. 1989 Apr; 36(4):432-8. Diederich CJ, Hynynen K. PMID: 2714822.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    113. A spherical source model for the thermal pulse decay method of measuring blood perfusion: a sensitivity analysis. J Biomech Eng. 1989 Feb; 111(1):55-61. Diederich CJ, Clegg S, Roemer RB. PMID: 2747234.
      View in: PubMed   Mentions: 2     Fields:    
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