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Endogenous opioid signalling regulates spinal ependymal cell proliferation. Nature. 2024 Sep 18.
Yue WWS, Touhara KK, Toma K, Duan X, Julius D. PMID: 39294372.
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Translation:
AnimalsCells
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Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat Struct Mol Biol. 2024 Sep; 31(9):1377-1385.
Arnold WR, Mancino A, Moss FR, Frost A, Julius D, Cheng Y. PMID: 38698206; PMCID: PMC11402599.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut. bioRxiv. 2024 Apr 25.
Touhara KK, Rossen ND, Deng F, Chu T, Harrington AM, Garcia Caraballo S, Brizuela M, O'Donnell T, Cil O, Brierley SM, Li Y, Julius D. PMID: 38370814; PMCID: PMC10871270.
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Neuroendocrine cells initiate protective upper airway reflexes. Science. 2024 Apr 19; 384(6693):295-301.
Seeholzer LF, Julius D. PMID: 38669574; PMCID: PMC11407116.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Structural basis of TRPV1 modulation by endogenous bioactive lipids. bioRxiv. 2023 Sep 19.
Arnold WR, Mancino A, Moss FR, Frost A, Julius D, Cheng Y. PMID: 37292745; PMCID: PMC10245640.
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Endogenous Opioid Signaling Regulates Proliferation of Spinal Cord Ependymal Cells. bioRxiv. 2023 Sep 08.
Yue WWS, Touhara KK, Toma K, Duan X, Julius D. PMID: 38883735; PMCID: PMC11178014.
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Gut enterochromaffin cells drive visceral pain and anxiety. Nature. 2023 04; 616(7955):137-142.
Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D. PMID: 36949192; PMCID: PMC10827380.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM. STAR Protoc. 2022 12 16; 3(4):101732.
Zhang K, Julius D, Cheng Y. PMID: 36181684; PMCID: PMC9530669.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons. Elife. 2022 08 15; 11.
Yue WWS, Yuan L, Braz JM, Basbaum AI, Julius D. PMID: 35968676; PMCID: PMC9377796.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Sensory TRP Channels in Three Dimensions. Annu Rev Biochem. 2022 06 21; 91:629-649.
Diver MM, Lin King JV, Julius D, Cheng Y. PMID: 35287474; PMCID: PMC9233036.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell. 2021 09 30; 184(20):5138-5150.e12.
Zhang K, Julius D, Cheng Y. PMID: 34496225; PMCID: PMC8488022.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature. 2020 09; 585(7823):141-145.
Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D. PMID: 32641835; PMCID: PMC7483980.
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PubMed Mentions:
71 Fields:
Translation:
HumansCells
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Structural insights into TRPM8 inhibition and desensitization. Science. 2019 09 27; 365(6460):1434-1440.
Diver MM, Cheng Y, Julius D. PMID: 31488702; PMCID: PMC7262954.
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PubMed Mentions:
86 Fields:
Translation:
HumansAnimalsCells
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A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain. Cell. 2019 09 05; 178(6):1362-1374.e16.
Lin King JV, Emrick JJ, Kelly MJS, Herzig V, King GF, Medzihradszky KF, Julius D. PMID: 31447178; PMCID: PMC6731142.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment. Curr Opin Struct Biol. 2019 10; 58:259-268.
Autzen HE, Julius D, Cheng Y. PMID: 31279500; PMCID: PMC6778513.
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PubMed Mentions:
33 Fields:
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Structural insight into TRPV5 channel function and modulation. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8869-8878.
Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J. PMID: 30975749; PMCID: PMC6500171.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E12091-E12100.
Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D. PMID: 30463955; PMCID: PMC6305010.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Molecular tuning of electroreception in sharks and skates. Nature. 2018 06; 558(7708):122-126.
Bellono NW, Leitch DB, Julius D. PMID: 29849147; PMCID: PMC6101975.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Structure of the human TRPM4 ion channel in a lipid nanodisc. Science. 2018 01 12; 359(6372):228-232.
Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, Cheng Y. PMID: 29217581; PMCID: PMC5898196.
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PubMed Mentions:
144 Fields:
Translation:
HumansCells
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Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell. 2017 Jun 29; 170(1):185-198.e16.
Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D. PMID: 28648659; PMCID: PMC5839326.
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PubMed Mentions:
340 Fields:
Translation:
HumansAnimalsCells
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Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6836-6841.
Osteen JD, Sampson K, Iyer V, Julius D, Bosmans F. PMID: 28607094; PMCID: PMC5495237.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Molecular basis of ancestral vertebrate electroreception. Nature. 2017 03 16; 543(7645):391-396.
Bellono NW, Leitch DB, Julius D. PMID: 28264196; PMCID: PMC5354974.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2524-E2532.
Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D. PMID: 28265084; PMCID: PMC5373363.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 06 23; 534(7608):494-9.
Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. PMID: 27281198; PMCID: PMC4919188.
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PubMed Mentions:
129 Fields:
Translation:
AnimalsCells
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TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature. 2016 06 16; 534(7607):347-51.
Gao Y, Cao E, Julius D, Cheng Y. PMID: 27281200; PMCID: PMC4911334.
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PubMed Mentions:
407 Fields:
Translation:
AnimalsCells
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Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015 Sep 24; 525(7570):552.
Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D. PMID: 26200340.
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PubMed Mentions:
62 Fields:
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Editorial overview: molecular biology of sensation. Curr Opin Neurobiol. 2015 Oct; 34:v-vi.
Julius D, Carlson JR. PMID: 26209561.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015 Apr 23; 520(7548):511-7.
Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D. PMID: 25855297; PMCID: PMC4409540.
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PubMed Mentions:
272 Fields:
Translation:
HumansCells
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Single particle electron cryo-microscopy of a mammalian ion channel. Curr Opin Struct Biol. 2014 Aug; 27:1-7.
Liao M, Cao E, Julius D, Cheng Y. PMID: 24681231; PMCID: PMC4176607.
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PubMed Mentions:
42 Fields:
Translation:
Animals
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X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel. Cell. 2014 Feb 13; 156(4):717-29.
Baconguis I, Bohlen CJ, Goehring A, Julius D, Gouaux E. PMID: 24507937; PMCID: PMC4190031.
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PubMed Mentions:
152 Fields:
Translation:
AnimalsCells
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Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013 Dec 05; 504(7478):107-12.
Liao M, Cao E, Julius D, Cheng Y. PMID: 24305160; PMCID: PMC4078027.
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PubMed Mentions:
808 Fields:
Translation:
HumansAnimalsCells
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TRPV1 structures in distinct conformations reveal activation mechanisms. Nature. 2013 Dec 05; 504(7478):113-8.
Cao E, Liao M, Cheng Y, Julius D. PMID: 24305161; PMCID: PMC4023639.
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PubMed Mentions:
524 Fields:
Translation:
AnimalsCells
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TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron. 2013 Feb 20; 77(4):667-79.
Cao E, Cordero-Morales JF, Liu B, Qin F, Julius D. PMID: 23439120; PMCID: PMC3583019.
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PubMed Mentions:
152 Fields:
Translation:
AnimalsCells
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TRP channels and pain. Annu Rev Cell Dev Biol. 2013; 29:355-84.
Julius D. PMID: 24099085.
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PubMed Mentions:
527 Fields:
Translation:
HumansAnimals
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Receptor-targeting mechanisms of pain-causing toxins: How ow? Toxicon. 2012 Sep 01; 60(3):254-64.
Bohlen CJ, Julius D. PMID: 22538196; PMCID: PMC3383939.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Signaling by sensory receptors. Cold Spring Harb Perspect Biol. 2012 Jan 01; 4(1):a005991.
Julius D, Nathans J. PMID: 22110046; PMCID: PMC3249628.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16; 479(7373):410-4.
Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D. PMID: 22094702; PMCID: PMC3226747.
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PubMed Mentions:
161 Fields:
Translation:
HumansAnimalsCells
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Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):E1184-91.
Cordero-Morales JF, Gracheva EO, Julius D. PMID: 21930928; PMCID: PMC3219143.
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PubMed Mentions:
121 Fields:
Translation:
HumansAnimalsCells
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Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature. 2011 Aug 03; 476(7358):88-91.
Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D. PMID: 21814281; PMCID: PMC3535012.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimalsCells
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Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci. 2011 Jul 13; 31(28):10119-27.
Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI. PMID: 21752988; PMCID: PMC3147010.
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PubMed Mentions:
145 Fields:
Translation:
AnimalsCells
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Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 2011 Mar 30; 31(13):5067-77.
Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI. PMID: 21451044; PMCID: PMC3087977.
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PubMed Mentions:
275 Fields:
Translation:
HumansAnimalsCells
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A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell. 2010 May 28; 141(5):834-45.
Bohlen CJ, Priel A, Zhou S, King D, Siemens J, Julius D. PMID: 20510930; PMCID: PMC2905675.
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PubMed Mentions:
156 Fields:
Translation:
HumansAnimalsCells
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Molecular basis of infrared detection by snakes. Nature. 2010 Apr 15; 464(7291):1006-11.
Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D. PMID: 20228791; PMCID: PMC2855400.
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PubMed Mentions:
172 Fields:
Translation:
AnimalsCells
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Cellular and molecular mechanisms of pain. Cell. 2009 Oct 16; 139(2):267-84.
Basbaum AI, Bautista DM, Scherrer G, Julius D. PMID: 19837031; PMCID: PMC2852643.
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PubMed Mentions:
1618 Fields:
Translation:
HumansAnimalsCells
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Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29; 4(5):e5741.
Myers BR, Sigal YM, Julius D. PMID: 19492038; PMCID: PMC2683941.
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PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
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Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):20015-20.
Bhattacharya MR, Bautista DM, Wu K, Haeberle H, Lumpkin EA, Julius D. PMID: 19060212; PMCID: PMC2604979.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Multiple unbiased prospective screens identify TRP channels and their conserved gating elements. J Gen Physiol. 2008 Nov; 132(5):481-6.
Myers BR, Saimi Y, Julius D, Kung C. PMID: 18955590; PMCID: PMC2571970.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci. 2008 Oct 01; 28(40):10102-10.
Prober DA, Zimmerman S, Myers BR, McDermott BM, Kim SH, Caron S, Rihel J, Solnica-Krezel L, Julius D, Hudspeth AJ, Schier AF. PMID: 18829968; PMCID: PMC2728686.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci. 2008 Jul; 11(7):772-9.
Bautista DM, Sigal YM, Milstein AD, Garrison JL, Zorn JA, Tsuruda PR, Nicoll RA, Julius D. PMID: 18568022; PMCID: PMC3072296.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron. 2008 May 08; 58(3):362-73.
Myers BR, Bohlen CJ, Julius D. PMID: 18466747; PMCID: PMC2422846.
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PubMed Mentions:
77 Fields:
Translation:
HumansAnimalsCells
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Fire in the hole: pore dilation of the capsaicin receptor TRPV1. Nat Neurosci. 2008 May; 11(5):528-9.
Bautista D, Julius D. PMID: 18437189.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13525-30.
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM. PMID: 17686976; PMCID: PMC1941642.
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PubMed Mentions:
493 Fields:
Translation:
HumansAnimalsCells
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13519-24.
Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. PMID: 17684094; PMCID: PMC1948902.
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PubMed Mentions:
352 Fields:
Translation:
HumansCells
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TRP channel structural biology: new roles for an old fold. Neuron. 2007 Jun 21; 54(6):847-50.
Myers BR, Julius D. PMID: 17582323.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 Jul 12; 448(7150):204-8.
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. PMID: 17538622.
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PubMed Mentions:
599 Fields:
Translation:
Animals
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Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain. 2007 Aug; 130(3):235-248.
Kayser V, Elfassi IE, Aubel B, Melfort M, Julius D, Gingrich JA, Hamon M, Bourgoin S. PMID: 17250964.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19564-8.
Hinman A, Chuang HH, Bautista DM, Julius D. PMID: 17164327; PMCID: PMC1748265.
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PubMed Mentions:
414 Fields:
Translation:
HumansCells
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The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci. 2006 Dec; 9(12):1512-9.
Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, Julius D. PMID: 17115040.
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PubMed Mentions:
677 Fields:
Translation:
AnimalsCells
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Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature. 2006 Nov 09; 444(7116):208-12.
Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. PMID: 17093448.
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PubMed Mentions:
127 Fields:
Translation:
HumansAnimalsCells
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Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse. Pain. 2006 Dec 15; 126(1-3):184-97.
Eckert WA, Julius D, Basbaum AI. PMID: 16945484.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Coiled coils direct assembly of a cold-activated TRP channel. Neuron. 2006 Jul 20; 51(2):201-12.
Tsuruda PR, Julius D, Minor DL. PMID: 16846855; PMCID: PMC3014052.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer's organ of the mole. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9339-44.
Marasco PD, Tsuruda PR, Bautista DM, Julius D, Catania KC. PMID: 16751268; PMCID: PMC1482611.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Toward better pain control. Sci Am. 2006 Jun; 294(6):60-7.
Basbaum AI, Julius D. PMID: 16711361.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24; 124(6):1269-82.
Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. PMID: 16564016.
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PubMed Mentions:
865 Fields:
Translation:
AnimalsCellsPHPublic Health
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International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev. 2005 Dec; 57(4):427-50.
Clapham DE, Julius D, Montell C, Schultz G. PMID: 16382100.
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PubMed Mentions:
161 Fields:
Translation:
HumansAnimals
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A neuropeptide courier for delta-opioid receptors? Cell. 2005 Aug 26; 122(4):496-8.
Julius D, Basbaum AI. PMID: 16122418.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12248-52.
Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. PMID: 16103371; PMCID: PMC1189336.
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PubMed Mentions:
344 Fields:
Translation:
HumansAnimalsCells
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Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci. 2005 Mar 23; 25(12):3126-31.
Ghilardi JR, Röhrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Halvorson KG, Poblete J, Chaplan SR, Dubin AE, Carruthers NI, Swanson D, Kuskowski M, Flores CM, Julius D, Mantyh PW. PMID: 15788769; PMCID: PMC6725088.
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PubMed Mentions:
142 Fields:
Translation:
AnimalsCells
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From peppers to peppermints: natural products as probes of the pain pathway. Harvey Lect. 2005-2006; 101:89-115.
Julius D. PMID: 18030977.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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A Nobel for smell. Cell. 2004 Dec 17; 119(6):747-52.
Julius D, Katz LC. PMID: 15607972.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron. 2004 Sep 16; 43(6):859-69.
Chuang HH, Neuhausser WM, Julius D. PMID: 15363396.
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PubMed Mentions:
136 Fields:
Translation:
HumansAnimalsCells
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Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. J Neurosci. 2004 Jun 16; 24(24):5537-48.
Bhattacharya A, Dang H, Zhu QM, Schnegelsberg B, Rozengurt N, Cain G, Prantil R, Vorp DA, Guy N, Julius D, Ford AP, Lester HA, Cockayne DA. PMID: 15201326; PMCID: PMC6729324.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor. Physiol Behav. 2004 Jun; 81(4):545-55.
Bhatnagar S, Sun LM, Raber J, Maren S, Julius D, Dallman MF. PMID: 15178147.
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PubMed Mentions:
33 Fields:
Translation:
Animals
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Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat. Eur J Neurosci. 2004 Apr; 19(7):1789-99.
Sanderson Nydahl K, Skinner K, Julius D, Basbaum AI. PMID: 15078552.
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PubMed Mentions:
18 Translation:
AnimalsCells
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Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol. 2004 Mar 15; 470(4):400-8.
Lewinter RD, Skinner K, Julius D, Basbaum AI. PMID: 14961565.
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PubMed Mentions:
23 Fields:
Translation:
Animals
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004 Jan 15; 427(6971):260-5.
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. PMID: 14712238.
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PubMed Mentions:
803 Fields:
Translation:
HumansAnimalsCells
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International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev. 2003 Dec; 55(4):591-6.
Clapham DE, Montell C, Schultz G, Julius D, International Union of Pharmacology. PMID: 14657417.
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83 Fields:
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AnimalsCells
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Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol. 2003 Aug; 13(4):487-92.
Jordt SE, McKemy DD, Julius D. PMID: 12965298.
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136 Fields:
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HumansAnimalsCells
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A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science. 2003 May 23; 300(5623):1284-8.
Prescott ED, Julius D. PMID: 12764195.
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211 Fields:
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HumansAnimalsCells
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Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002 Mar 07; 416(6876):52-8.
McKemy DD, Neuhausser WM, Julius D. PMID: 11882888.
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956 Fields:
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AnimalsCells
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Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell. 2002 Feb 08; 108(3):421-30.
Jordt SE, Julius D. PMID: 11853675.
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309 Fields:
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AnimalsCells
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The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci. 2002 Feb 01; 22(3):1010-9.
Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI. PMID: 11826129; PMCID: PMC6758503.
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111 Fields:
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AnimalsCells
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A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002 Feb; 9(2):229-31.
Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. PMID: 11864597.
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193 Fields:
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HumansAnimalsCells
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Molecular mechanisms of nociception. Nature. 2001 Sep 13; 413(6852):203-10.
Julius D, Basbaum AI. PMID: 11557989.
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732 Fields:
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HumansAnimalsCells
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ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9086-91.
McNamara N, Khong A, McKemy D, Caterina M, Boyer J, Julius D, Basbaum C. PMID: 11481474; PMCID: PMC55377.
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PubMed Mentions:
38 Fields:
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HumansCells
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Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature. 2001 Jun 21; 411(6840):957-62.
Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D. PMID: 11418861.
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452 Fields:
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AnimalsCells
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Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature. 2001 Jan 11; 409(6817):202-7.
Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB. PMID: 11196645.
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PubMed Mentions:
340 Fields:
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HumansAnimalsCells
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The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci. 2001; 24:487-517.
Caterina MJ, Julius D. PMID: 11283319.
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487 Fields:
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HumansAnimalsCells
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Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8134-9.
Jordt SE, Tominaga M, Julius D. PMID: 10859346; PMCID: PMC16682.
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PubMed Mentions:
255 Fields:
Translation:
Cells
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Capsaicin receptor in the pain pathway. Jpn J Pharmacol. 2000 May; 83(1):20-4.
Tominaga M, Julius D. PMID: 10887936.
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PubMed Mentions:
25 Fields:
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HumansAnimals
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Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 2000 Apr 14; 288(5464):306-13.
Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. PMID: 10764638.
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1296 Fields:
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AnimalsCells
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Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol. 1999 Oct; 9(5):525-30.
Caterina MJ, Julius D. PMID: 10508737.
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PubMed Mentions:
40 Fields:
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HumansAnimalsCells
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Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):275-84.
Melck D, Bisogno T, De Petrocellis L, Chuang H, Julius D, Bifulco M, Di Marzo V. PMID: 10448105.
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PubMed Mentions:
55 Fields:
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HumansAnimalsCells
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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. 1999 Jul 29; 400(6743):452-7.
Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgård M, Di Marzo V, Julius D, Högestätt ED. PMID: 10440374.
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PubMed Mentions:
733 Fields:
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AnimalsCells
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A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999 Apr 01; 398(6726):436-41.
Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. PMID: 10201375.
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501 Fields:
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HumansAnimalsCells
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Serotonin receptor knockouts: a moody subject. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15153-4.
Julius D. PMID: 9860934; PMCID: PMC33926.
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PubMed Mentions:
7 Fields:
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HumansAnimals
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The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron. 1998 Sep; 21(3):531-43.
Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D. PMID: 9768840.
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PubMed Mentions:
1044 Fields:
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HumansAnimalsCells
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Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes. J Neurosci. 1998 Aug 15; 18(16):6186-94.
Bedford FK, Julius D, Ingraham HA. PMID: 9698312; PMCID: PMC6793193.
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PubMed Mentions:
15 Fields:
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HumansAnimalsCells
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Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails. Science. 1998 Jul 24; 281(5376):575-8.
England LJ, Imperial J, Jacobsen R, Craig AG, Gulyas J, Akhtar M, Rivier J, Julius D, Olivera BM. PMID: 9677203.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997 Oct 23; 389(6653):816-24.
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. PMID: 9349813.
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2999 Fields:
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HumansAnimalsCells
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ATP receptors in sickness, pain and death. Chem Biol. 1996 Apr; 3(4):229-32.
Brake A, Schumacher M, Julius D. PMID: 8807849.
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PubMed Mentions:
2 Fields:
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Animals
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Signaling by extracellular nucleotides. Annu Rev Cell Dev Biol. 1996; 12:519-41.
Brake AJ, Julius D. PMID: 8970736.
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26 Fields:
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HumansAnimalsCells
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Pharmacology. Home for an orphan endorphin. Nature. 1995 Oct 12; 377(6549):476.
Julius D. PMID: 7566139.
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PubMed Mentions:
4 Fields:
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AnimalsCells
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Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature. 1995 Apr 06; 374(6522):542-6.
Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. PMID: 7700379.
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311 Fields:
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AnimalsCells
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Expression of a serotonin-gated ion channel in embryonic neural and nonneural tissues. Mol Cell Neurosci. 1995 Feb; 6(1):43-55.
Tecott L, Shtrom S, Julius D. PMID: 7541286.
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16 Fields:
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AnimalsCells
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New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature. 1994 Oct 06; 371(6497):519-23.
Brake AJ, Wagenbach MJ, Julius D. PMID: 7523952.
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246 Fields:
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AnimalsCells
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A new wave of serotonin receptors. Curr Opin Neurobiol. 1993 Jun; 3(3):310-5.
Tecott LH, Julius D. PMID: 8369625.
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PubMed Mentions:
7 Fields:
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HumansAnimalsCells
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Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5113-7.
Lustig KD, Shiau AK, Brake AJ, Julius D. PMID: 7685114; PMCID: PMC46665.
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PubMed Mentions:
164 Fields:
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HumansAnimalsCells
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Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 1993 May 20; 363(6426):274-6.
Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. PMID: 8387644.
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211 Fields:
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HumansAnimalsCells
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Nervous system distribution of the serotonin 5-HT3 receptor mRNA. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1430-4.
Tecott LH, Maricq AV, Julius D. PMID: 8434003; PMCID: PMC45887.
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PubMed Mentions:
102 Fields:
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AnimalsCells
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Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4). Hum Mol Genet. 1992 Dec; 1(9):681-4.
Milatovich A, Hsieh CL, Bonaminio G, Tecott L, Julius D, Francke U. PMID: 1302605.
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PubMed Mentions:
13 Fields:
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HumansAnimalsCells
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Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype. Exp Cell Res. 1992 Jun; 200(2):523-7.
Kahan C, Julius D, Pouysségur J, Seuwen K. PMID: 1315291.
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PubMed Mentions:
1 Fields:
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AnimalsCells
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Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science. 1991 Oct 18; 254(5030):432-7.
Maricq AV, Peterson AS, Brake AJ, Myers RM, Julius D. PMID: 1718042.
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233 Fields:
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AnimalsCells
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Molecular biology of serotonin receptors. Annu Rev Neurosci. 1991; 14:335-60.
Julius D. PMID: 2031574.
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31 Fields:
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HumansAnimalsCells
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The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet. 1990 Nov; 16(6):567-74.
Hsieh CL, Bowcock AM, Farrer LA, Hebert JM, Huang KN, Cavalli-Sforza LL, Julius D, Francke U. PMID: 1980030.
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PubMed Mentions:
13 Fields:
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HumansAnimalsCells
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The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci U S A. 1990 Feb; 87(3):928-32.
Julius D, Huang KN, Livelli TJ, Axel R, Jessell TM. PMID: 2300586; PMCID: PMC53382.
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53 Fields:
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AnimalsCells
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5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6793-7.
Molineaux SM, Jessell TM, Axel R, Julius D. PMID: 2771958; PMCID: PMC297932.
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63 Fields:
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AnimalsCells
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Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science. 1989 Jun 02; 244(4908):1057-62.
Julius D, Livelli TJ, Jessell TM, Axel R. PMID: 2727693.
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73 Fields:
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AnimalsCells
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Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science. 1988 Jul 29; 241(4865):558-64.
Julius D, MacDermott AB, Axel R, Jessell TM. PMID: 3399891.
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130 Fields:
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AnimalsCells
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Functional expression of the 5-HT1c receptor in neuronal and nonneuronal cells. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:385-93.
Julius D, MacDermott AB, Jessel TM, Huang K, Molineaux S, Schieren I, Axel R. PMID: 3254776.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell. 1984 Jul; 37(3):1075-89.
Julius D, Brake A, Blair L, Kunisawa R, Thorner J. PMID: 6430565.
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180 Fields:
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AnimalsCells
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Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway. Cell. 1984 Feb; 36(2):309-18.
Julius D, Schekman R, Thorner J. PMID: 6420074.
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135 Fields:
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AnimalsCells
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A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence. Mol Cell Biol. 1983 Aug; 3(8):1440-50.
Brake AJ, Julius DJ, Thorner J. PMID: 6353204; PMCID: PMC369990.
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PubMed Mentions:
24 Fields:
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AnimalsCells
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Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell. 1983 Mar; 32(3):839-52.
Julius D, Blair L, Brake A, Sprague G, Thorner J. PMID: 6339075.
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PubMed Mentions:
132 Fields:
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AnimalsCells
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Isomeric specificity of aminoacylation of wheat germ transfer ribonucleic acid and the specificity of interaction of elongation factor Tu with aminoacyl transfer ribonucleic acid. Biochemistry. 1979 Feb 20; 18(4):604-9.
Julius DJ, Fraser TH, Rich A. PMID: 217420.
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AnimalsCells
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Determination of aminoacylation isomeric specificity using tRNA terminating in 3'-amino-3'-deoxyadenosine and 2'-amino-2'-deoxyadenosine. Methods Enzymol. 1979; 59:272-82.
Fraser TH, Julius DJ, Rich A. PMID: 374942.
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Cells