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David Julius, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
Address600 16th Street
San Francisco CA 94158
Phone415-476-0431
ORCID ORCID Icon0000-0002-6365-4867 Additional info
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    Other Positions
    Title(s)Chair, Physiology


    Collapse Biography 
    Collapse Awards and Honors
    University of North Carolina2001Perl-UNC Prize in Neuroscience
    Physiological Society of Stockholm2003Yngve Zotterman Prize
    2004Member, National Academy of Sciences
    2005Member, American Academy of Arts and Sciences
    American Pain Society2006Frederick W.L. Kerr Basic Science Research Award
    Max Planck Society, Germany2006K.J. Zülch Prize for Basic Neurological Research
    McGovern Institute for Brain Research at MIT2007Edward M. Scolnick Prize in Neuroscience
    Columbia University2007W. Alden Spencer Award
    Society for Neuroscience2007Julius Axelrod Prize
    Unilever, Inc.2007Unilever Science Prize
    2010Passano Award
    2010Hungarian Academy of Sciences (Honorary Member)
    2010Prince of Asturias Prize for Technical and Scientific Research
    2010Shaw Prize in Life Sciences and Medicine
    2012Member, National Academy of Medicine
    2013Paul Janssen Prize for Biomedical Research
    Biophysical Society2014Kenneth S. Cole Award
    University of Bordeaux, France2015Doctor Honoris Causa
    Human Frontiers Science Program Organization2017Nakasone Award
    Gairdner Foundation2017Canada Gairdner International Award
    Brandeis University2019Rosenstiel Basic Medical Sciences Award
    Breakthrough Prize Foundation2020Breakthrough Prize in Life Sciences
    Kavli Foundation2020Kavli Prize in Neuroscience

    Collapse Overview 
    Collapse Overview
    Our group is interested in understanding how sensory systems enable us to perceive our world. In one aspect of our research, we exploit the power of natural products to elucidate molecular mechanisms of touch and pain sensation. For example, we have asked how capsaicin, the main pungent ingredient in "hot" chili peppers, elicits burning pain, and how menthol, the cooling agent in mint leaves, evokes an icy cool sensation. Using these and other agents as pharmacological probes, we have identified ion channels on sensory nerve fibers that are activated by heat, cold, or chemical irritants, providing molecular insight into the process of thermosensation, pain, and itch. With the aid of genetic, electrophysiological, structural, and behavioral methods, we are asking how these ion channels are modulated in response to tumor growth, infection, or other forms of injury that produce inflammation and pain hypersensitivity. These basic scientific studies are helping to lay a foundation for the discovery and development of novel analgesic drugs.

    Collapse Research 
    Collapse Research Activities and Funding
    Mapping gut-spinal cord connections in visceral pain
    NIH/NINDS U01NS113869Sep 23, 2019 - Aug 31, 2022
    Role: Principal Investigator
    Natural products as probes of the pain pathway
    NIH/NINDS R35NS105038Dec 15, 2017 - Nov 30, 2025
    Role: Principal Investigator
    ASIC Channels and Pain
    NIH/NINDS R01NS081115Sep 1, 2012 - May 31, 2017
    Role: Principal Investigator
    Exploiting toxins to probe sensory signaling
    NIH/NINDS R01NS065071Jul 1, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Exploiting toxins to probe sensory signaling
    NIH/NINDS R37NS065071Apr 1, 2009 - Aug 31, 2018
    Role: Principal Investigator
    Cellular Physiology of Sensory Ion Channels
    NIH/NINDS R01NS055299Jul 1, 2006 - Jun 30, 2017
    Role: Principal Investigator
    Molecular Basis of Mechanoreception in Sensory Neurons
    NIH/NINDS R21NS049226Sep 1, 2005 - Aug 31, 2008
    Role: Principal Investigator
    LONGTERM CHANGES IN THE MAMMALIAN BRAIN
    NIH/NIMH P50MH048200Sep 1, 1991 - Aug 31, 2002
    Role: Co-Investigator
    Trigeminal Pain, Mechanisms and Control
    NIH/NIDCR P01DE008973Sep 1, 1990 - Sep 14, 2001
    Role: Co-Investigator
    Molecular Mechanisms of Receptor and Channel Function
    NIH/NINDS R01NS047723Apr 1, 1990 - Jun 30, 2017
    Role: Principal Investigator
    Molecular Mechanism of Receptor and Channel Function
    NIH/NINDS R37NS047723Apr 1, 1990 - Feb 28, 2011
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF RECEPTOR AND CHANNEL FUNCTION
    NIH/NIGMS R01GM044298Apr 1, 1990 - Mar 31, 2004
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structural insights into TRPM8 inhibition and desensitization. Science. 2019 09 27; 365(6460):1434-1440. Diver MM, Cheng Y, Julius D. PMID: 31488702.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain. Cell. 2019 09 05; 178(6):1362-1374.e16. Lin King JV, Emrick JJ, Kelly MJS, Herzig V, King GF, Medzihradszky KF, Julius D. PMID: 31447178.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment. Curr Opin Struct Biol. 2019 10; 58:259-268. Autzen HE, Julius D, Cheng Y. PMID: 31279500.
      View in: PubMed   Mentions:    Fields:    
    4. Structural insight into TRPV5 channel function and modulation. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8869-8878. Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J. PMID: 30975749.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    5. Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E12091-E12100. Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D. PMID: 30463955.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Molecular tuning of electroreception in sharks and skates. Nature. 2018 06; 558(7708):122-126. Bellono NW, Leitch DB, Julius D. PMID: 29849147.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Structure of the human TRPM4 ion channel in a lipid nanodisc. Science. 2018 01 12; 359(6372):228-232. Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, Cheng Y. PMID: 29217581.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    8. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell. 2017 Jun 29; 170(1):185-198.e16. Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D. PMID: 28648659.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    9. Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6836-6841. Osteen JD, Sampson K, Iyer V, Julius D, Bosmans F. PMID: 28607094.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Molecular basis of ancestral vertebrate electroreception. Nature. 2017 03 16; 543(7645):391-396. Bellono NW, Leitch DB, Julius D. PMID: 28264196.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    11. Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2524-E2532. Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D. PMID: 28265084.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 06 23; 534(7608):494-9. Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. PMID: 27281198.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    13. TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature. 2016 06 16; 534(7607):347-51. Gao Y, Cao E, Julius D, Cheng Y. PMID: 27281200.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    14. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015 Sep 24; 525(7570):552. Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D. PMID: 26200340.
      View in: PubMed   Mentions: 28     Fields:    
    15. Editorial overview: molecular biology of sensation. Curr Opin Neurobiol. 2015 Oct; 34:v-vi. Julius D, Carlson JR. PMID: 26209561.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    16. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015 Apr 23; 520(7548):511-7. Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D. PMID: 25855297.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansCells
    17. Single particle electron cryo-microscopy of a mammalian ion channel. Curr Opin Struct Biol. 2014 Aug; 27:1-7. Liao M, Cao E, Julius D, Cheng Y. PMID: 24681231.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    18. X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel. Cell. 2014 Feb 13; 156(4):717-29. Baconguis I, Bohlen CJ, Goehring A, Julius D, Gouaux E. PMID: 24507937.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    19. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013 Dec 05; 504(7478):107-12. Liao M, Cao E, Julius D, Cheng Y. PMID: 24305160.
      View in: PubMed   Mentions: 461     Fields:    Translation:HumansAnimalsCells
    20. TRPV1 structures in distinct conformations reveal activation mechanisms. Nature. 2013 Dec 05; 504(7478):113-8. Cao E, Liao M, Cheng Y, Julius D. PMID: 24305161.
      View in: PubMed   Mentions: 293     Fields:    Translation:AnimalsCells
    21. TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron. 2013 Feb 20; 77(4):667-79. Cao E, Cordero-Morales JF, Liu B, Qin F, Julius D. PMID: 23439120.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    22. TRP channels and pain. Annu Rev Cell Dev Biol. 2013; 29:355-84. Julius D. PMID: 24099085.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimals
    23. Receptor-targeting mechanisms of pain-causing toxins: How ow? Toxicon. 2012 Sep 01; 60(3):254-64. Bohlen CJ, Julius D. PMID: 22538196.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    24. Signaling by sensory receptors. Cold Spring Harb Perspect Biol. 2012 Jan 01; 4(1):a005991. Julius D, Nathans J. PMID: 22110046.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    25. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16; 479(7373):410-4. Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D. PMID: 22094702.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    26. Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):E1184-91. Cordero-Morales JF, Gracheva EO, Julius D. PMID: 21930928.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    27. Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature. 2011 Aug 03; 476(7358):88-91. Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D. PMID: 21814281.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    28. Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci. 2011 Jul 13; 31(28):10119-27. Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI. PMID: 21752988.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    29. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 2011 Mar 30; 31(13):5067-77. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI. PMID: 21451044.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    30. A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell. 2010 May 28; 141(5):834-45. Bohlen CJ, Priel A, Zhou S, King D, Siemens J, Julius D. PMID: 20510930.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    31. Molecular basis of infrared detection by snakes. Nature. 2010 Apr 15; 464(7291):1006-11. Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D. PMID: 20228791.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    32. Cellular and molecular mechanisms of pain. Cell. 2009 Oct 16; 139(2):267-84. Basbaum AI, Bautista DM, Scherrer G, Julius D. PMID: 19837031.
      View in: PubMed   Mentions: 781     Fields:    Translation:HumansAnimalsCells
    33. Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29; 4(5):e5741. Myers BR, Sigal YM, Julius D. PMID: 19492038.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    34. Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):20015-20. Bhattacharya MR, Bautista DM, Wu K, Haeberle H, Lumpkin EA, Julius D. PMID: 19060212.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    35. Multiple unbiased prospective screens identify TRP channels and their conserved gating elements. J Gen Physiol. 2008 Nov; 132(5):481-6. Myers BR, Saimi Y, Julius D, Kung C. PMID: 18955590.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    36. Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. J Neurosci. 2008 Oct 01; 28(40):10102-10. Prober DA, Zimmerman S, Myers BR, McDermott BM, Kim SH, Caron S, Rihel J, Solnica-Krezel L, Julius D, Hudspeth AJ, Schier AF. PMID: 18829968.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    37. Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci. 2008 Jul; 11(7):772-9. Bautista DM, Sigal YM, Milstein AD, Garrison JL, Zorn JA, Tsuruda PR, Nicoll RA, Julius D. PMID: 18568022.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    38. A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron. 2008 May 08; 58(3):362-73. Myers BR, Bohlen CJ, Julius D. PMID: 18466747.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    39. Fire in the hole: pore dilation of the capsaicin receptor TRPV1. Nat Neurosci. 2008 May; 11(5):528-9. Bautista D, Julius D. PMID: 18437189.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    40. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13525-30. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM. PMID: 17686976.
      View in: PubMed   Mentions: 326     Fields:    Translation:HumansAnimalsCells
    41. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13519-24. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. PMID: 17684094.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansCells
    42. TRP channel structural biology: new roles for an old fold. Neuron. 2007 Jun 21; 54(6):847-50. Myers BR, Julius D. PMID: 17582323.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    43. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 Jul 12; 448(7150):204-8. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. PMID: 17538622.
      View in: PubMed   Mentions: 357     Fields:    Translation:Animals
    44. Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain. 2007 Aug; 130(3):235-48. Kayser V, Elfassi IE, Aubel B, Melfort M, Julius D, Gingrich JA, Hamon M, Bourgoin S. PMID: 17250964.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    45. TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19564-8. Hinman A, Chuang HH, Bautista DM, Julius D. PMID: 17164327.
      View in: PubMed   Mentions: 297     Fields:    Translation:HumansCells
    46. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci. 2006 Dec; 9(12):1512-9. Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB, Julius D. PMID: 17115040.
      View in: PubMed   Mentions: 308     Fields:    Translation:AnimalsCells
    47. Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature. 2006 Nov 09; 444(7116):208-12. Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. PMID: 17093448.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    48. Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse. Pain. 2006 Dec 15; 126(1-3):184-97. Eckert WA, Julius D, Basbaum AI. PMID: 16945484.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    49. Coiled coils direct assembly of a cold-activated TRP channel. Neuron. 2006 Jul 20; 51(2):201-12. Tsuruda PR, Julius D, Minor DL. PMID: 16846855.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    50. Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer's organ of the mole. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9339-44. Marasco PD, Tsuruda PR, Bautista DM, Julius D, Catania KC. PMID: 16751268.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    51. Toward better pain control. Sci Am. 2006 Jun; 294(6):60-7. Basbaum AI, Julius D. PMID: 16711361.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    52. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24; 124(6):1269-82. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. PMID: 16564016.
      View in: PubMed   Mentions: 626     Fields:    Translation:AnimalsCellsPHPublic Health
    53. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev. 2005 Dec; 57(4):427-50. Clapham DE, Julius D, Montell C, Schultz G. PMID: 16382100.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    54. A neuropeptide courier for delta-opioid receptors? Cell. 2005 Aug 26; 122(4):496-8. Julius D, Basbaum AI. PMID: 16122418.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    55. Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12248-52. Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Högestätt ED, Julius D, Jordt SE, Zygmunt PM. PMID: 16103371.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansAnimalsCells
    56. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci. 2005 Mar 23; 25(12):3126-31. Ghilardi JR, Röhrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Halvorson KG, Poblete J, Chaplan SR, Dubin AE, Carruthers NI, Swanson D, Kuskowski M, Flores CM, Julius D, Mantyh PW. PMID: 15788769.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    57. From peppers to peppermints: natural products as probes of the pain pathway. Harvey Lect. 2005-2006; 101:89-115. Julius D. PMID: 18030977.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    58. A Nobel for smell. Cell. 2004 Dec 17; 119(6):747-52. Julius D, Katz LC. PMID: 15607972.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    59. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron. 2004 Sep 16; 43(6):859-69. Chuang HH, Neuhausser WM, Julius D. PMID: 15363396.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    60. Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. J Neurosci. 2004 Jun 16; 24(24):5537-48. Bhattacharya A, Dang H, Zhu QM, Schnegelsberg B, Rozengurt N, Cain G, Prantil R, Vorp DA, Guy N, Julius D, Ford AP, Lester HA, Cockayne DA. PMID: 15201326.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    61. Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor. Physiol Behav. 2004 Jun; 81(4):545-55. Bhatnagar S, Sun LM, Raber J, Maren S, Julius D, Dallman MF. PMID: 15178147.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    62. Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat. Eur J Neurosci. 2004 Apr; 19(7):1789-99. Sanderson Nydahl K, Skinner K, Julius D, Basbaum AI. PMID: 15078552.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    63. Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol. 2004 Mar 15; 470(4):400-8. Lewinter RD, Skinner K, Julius D, Basbaum AI. PMID: 14961565.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    64. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004 Jan 15; 427(6971):260-5. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Högestätt ED, Meng ID, Julius D. PMID: 14712238.
      View in: PubMed   Mentions: 576     Fields:    Translation:HumansAnimalsCells
    65. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev. 2003 Dec; 55(4):591-6. Clapham DE, Montell C, Schultz G, Julius D. PMID: 14657417.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    66. Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol. 2003 Aug; 13(4):487-92. Jordt SE, McKemy DD, Julius D. PMID: 12965298.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    67. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science. 2003 May 23; 300(5623):1284-8. Prescott ED, Julius D. PMID: 12764195.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    68. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002 Mar 07; 416(6876):52-8. McKemy DD, Neuhausser WM, Julius D. PMID: 11882888.
      View in: PubMed   Mentions: 596     Fields:    Translation:AnimalsCells
    69. Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell. 2002 Feb 08; 108(3):421-30. Jordt SE, Julius D. PMID: 11853675.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    70. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci. 2002 Feb 01; 22(3):1010-9. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI. PMID: 11826129.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    71. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002 Feb; 9(2):229-31. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. PMID: 11864597.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    72. Molecular mechanisms of nociception. Nature. 2001 Sep 13; 413(6852):203-10. Julius D, Basbaum AI. PMID: 11557989.
      View in: PubMed   Mentions: 482     Fields:    Translation:HumansAnimalsCells
    73. ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9086-91. McNamara N, Khong A, McKemy D, Caterina M, Boyer J, Julius D, Basbaum C. PMID: 11481474.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    74. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature. 2001 Jun 21; 411(6840):957-62. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D. PMID: 11418861.
      View in: PubMed   Mentions: 352     Fields:    Translation:AnimalsCells
    75. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature. 2001 Jan 11; 409(6817):202-7. Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB. PMID: 11196645.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    76. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci. 2001; 24:487-517. Caterina MJ, Julius D. PMID: 11283319.
      View in: PubMed   Mentions: 352     Fields:    Translation:HumansAnimalsCells
    77. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8134-9. Jordt SE, Tominaga M, Julius D. PMID: 10859346.
      View in: PubMed   Mentions: 175     Fields:    Translation:Cells
    78. Capsaicin receptor in the pain pathway. Jpn J Pharmacol. 2000 May; 83(1):20-4. Tominaga M, Julius D. PMID: 10887936.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    79. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 2000 Apr 14; 288(5464):306-13. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. PMID: 10764638.
      View in: PubMed   Mentions: 875     Fields:    Translation:AnimalsCells
    80. Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol. 1999 Oct; 9(5):525-30. Caterina MJ, Julius D. PMID: 10508737.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    81. Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):275-84. Melck D, Bisogno T, De Petrocellis L, Chuang H, Julius D, Bifulco M, Di Marzo V. PMID: 10448105.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    82. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. 1999 Jul 29; 400(6743):452-7. Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgård M, Di Marzo V, Julius D, Högestätt ED. PMID: 10440374.
      View in: PubMed   Mentions: 568     Fields:    Translation:AnimalsCells
    83. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999 Apr 01; 398(6726):436-41. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. PMID: 10201375.
      View in: PubMed   Mentions: 317     Fields:    Translation:HumansAnimalsCells
    84. Serotonin receptor knockouts: a moody subject. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15153-4. Julius D. PMID: 9860934.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    85. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron. 1998 Sep; 21(3):531-43. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D. PMID: 9768840.
      View in: PubMed   Mentions: 726     Fields:    Translation:HumansAnimalsCells
    86. Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes. J Neurosci. 1998 Aug 15; 18(16):6186-94. Bedford FK, Julius D, Ingraham HA. PMID: 9698312.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    87. Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails. Science. 1998 Jul 24; 281(5376):575-8. England LJ, Imperial J, Jacobsen R, Craig AG, Gulyas J, Akhtar M, Rivier J, Julius D, Olivera BM. PMID: 9677203.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    88. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997 Oct 23; 389(6653):816-24. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. PMID: 9349813.
      View in: PubMed   Mentions: 1918     Fields:    Translation:HumansAnimalsCells
    89. ATP receptors in sickness, pain and death. Chem Biol. 1996 Apr; 3(4):229-32. Brake A, Schumacher M, Julius D. PMID: 8807849.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    90. Signaling by extracellular nucleotides. Annu Rev Cell Dev Biol. 1996; 12:519-41. Brake AJ, Julius D. PMID: 8970736.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    91. Pharmacology. Home for an orphan endorphin. Nature. 1995 Oct 12; 377(6549):476. Julius D. PMID: 7566139.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    92. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature. 1995 Apr 06; 374(6522):542-6. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. PMID: 7700379.
      View in: PubMed   Mentions: 234     Fields:    Translation:AnimalsCells
    93. Expression of a serotonin-gated ion channel in embryonic neural and nonneural tissues. Mol Cell Neurosci. 1995 Feb; 6(1):43-55. Tecott L, Shtrom S, Julius D. PMID: 7541286.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    94. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature. 1994 Oct 06; 371(6497):519-23. Brake AJ, Wagenbach MJ, Julius D. PMID: 7523952.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    95. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5113-7. Lustig KD, Shiau AK, Brake AJ, Julius D. PMID: 7685114.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    96. A new wave of serotonin receptors. Curr Opin Neurobiol. 1993 Jun; 3(3):310-5. Tecott LH, Julius D. PMID: 8369625.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    97. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 1993 May 20; 363(6426):274-6. Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. PMID: 8387644.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    98. Nervous system distribution of the serotonin 5-HT3 receptor mRNA. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1430-4. Tecott LH, Maricq AV, Julius D. PMID: 8434003.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    99. Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4). Hum Mol Genet. 1992 Dec; 1(9):681-4. Milatovich A, Hsieh CL, Bonaminio G, Tecott L, Julius D, Francke U. PMID: 1302605.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    100. Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype. Exp Cell Res. 1992 Jun; 200(2):523-7. Kahan C, Julius D, Pouysségur J, Seuwen K. PMID: 1315291.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    101. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science. 1991 Oct 18; 254(5030):432-7. Maricq AV, Peterson AS, Brake AJ, Myers RM, Julius D. PMID: 1718042.
      View in: PubMed   Mentions: 194     Fields:    Translation:AnimalsCells
    102. Molecular biology of serotonin receptors. Annu Rev Neurosci. 1991; 14:335-60. Julius D. PMID: 2031574.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    103. The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14. Somat Cell Mol Genet. 1990 Nov; 16(6):567-74. Hsieh CL, Bowcock AM, Farrer LA, Hebert JM, Huang KN, Cavalli-Sforza LL, Julius D, Francke U. PMID: 1980030.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    104. The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci U S A. 1990 Feb; 87(3):928-32. Julius D, Huang KN, Livelli TJ, Axel R, Jessell TM. PMID: 2300586.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    105. 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6793-7. Molineaux SM, Jessell TM, Axel R, Julius D. PMID: 2771958.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    106. Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science. 1989 Jun 02; 244(4908):1057-62. Julius D, Livelli TJ, Jessell TM, Axel R. PMID: 2727693.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    107. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science. 1988 Jul 29; 241(4865):558-64. Julius D, MacDermott AB, Axel R, Jessell TM. PMID: 3399891.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    108. Functional expression of the 5-HT1c receptor in neuronal and nonneuronal cells. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:385-93. Julius D, MacDermott AB, Jessel TM, Huang K, Molineaux S, Schieren I, Axel R. PMID: 3254776.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    109. Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell. 1984 Jul; 37(3):1075-89. Julius D, Brake A, Blair L, Kunisawa R, Thorner J. PMID: 6430565.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    110. Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway. Cell. 1984 Feb; 36(2):309-18. Julius D, Schekman R, Thorner J. PMID: 6420074.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    111. A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence. Mol Cell Biol. 1983 Aug; 3(8):1440-50. Brake AJ, Julius DJ, Thorner J. PMID: 6353204.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    112. Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell. 1983 Mar; 32(3):839-52. Julius D, Blair L, Brake A, Sprague G, Thorner J. PMID: 6339075.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    113. Isomeric specificity of aminoacylation of wheat germ transfer ribonucleic acid and the specificity of interaction of elongation factor Tu with aminoacyl transfer ribonucleic acid. Biochemistry. 1979 Feb 20; 18(4):604-9. Julius DJ, Fraser TH, Rich A. PMID: 217420.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    114. Determination of aminoacylation isomeric specificity using tRNA terminating in 3'-amino-3'-deoxyadenosine and 2'-amino-2'-deoxyadenosine. Methods Enzymol. 1979; 59:272-82. Fraser TH, Julius DJ, Rich A. PMID: 374942.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
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