Nadav Ahituv, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address1550 Fourth St, #584C
San Francisco CA 94158
ORCID ORCID Icon0000-0002-7434-8144 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Tel-Aviv University2002  - 2002Ph.D. with distinction
    The American Society for Clinical Pharmacology and Therapeutics2014  - 2014ASCPT Leon I. Goldberg young investigator award

    Collapse Overview 
    Collapse Overview
    The Ahituv lab is focused on identifying gene regulatory elements and linking nucleotide variation within them to various phenotypes including morphological differences between species, drug response and human disease. In addition, our lab is developing massively parallel reporter assays (MPRAs) that allow for high-throughput functional characterization of gene regulatory elements and the use of gene regulatory elements as therapeutic targets or disease diagnostic markers.

    Collapse Research 
    Collapse Research Activities and Funding
    Massively parallel characterization of variants and elements impacting transcriptional regulation in dynamic cellular systems
    NIH UM1HG011966Sep 1, 2021 - May 31, 2026
    Role: Co-Principal Investigator
    From Obesity GWAS to therapeutic targets
    NIH R01DK124769Jul 1, 2020 - Jun 30, 2025
    Role: Co-Principal Investigator
    Technologies for simultaneous characterization of regulatory activity and protein binding
    NIH R21HG010683Aug 16, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Genetic Etiology of Abdominal Hernia Susceptibility
    NIH R01DK116738Sep 15, 2018 - Aug 31, 2021
    Role: Co-Principal Investigator
    Massively parallel characterization of psychiatric disease associated regulatory elements in defined cell types
    NIH U01MH116438Jul 6, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Development of massively parallel reporter assays that use cognate promoters
    NIH R21HG010065May 1, 2018 - Apr 30, 2020
    Role: Co-Principal Investigator
    Massively parallel reporter assays and genome editing of ENCODE predicted regulatory elements
    NIH UM1HG009408Feb 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Developmental Mechanisms of Human Idiopathic Scoliosis
    NIH P01HD084387Sep 1, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Massively parallel dissection of psychiatric regulatory networks
    NIH R01MH109907May 1, 2016 - Feb 28, 2021
    Role: Co-Principal Investigator
    The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with Asthma
    NIH R01HL117004Aug 1, 2013 - Jun 30, 2023
    Role: Co-Principal Investigator
    Identification & functional characterization of SIM1 obesity-associated variants
    NIH R01DK090382May 1, 2012 - Mar 31, 2016
    Role: Co-Principal Investigator
    Massively parallel, in vivo functional testing of regulatory elements
    NIH R01HG006768Apr 24, 2012 - Jun 30, 2015
    Role: Co-Principal Investigator
    Characterization of neuronal gene regulatory elements associated with epilepsy
    NIH R01NS079231Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Computational & Functional Annotation of the Zebrafish Genome Regulatory Toolbox
    NIH R01HG005058Sep 29, 2009 - Jul 31, 2014
    Role: Co-Principal Investigator
    Characterization of regulatory elements leading to human limb malformations
    NIH R01HD059862Apr 1, 2009 - Mar 31, 2015
    Role: Principal Investigator
    Pharmacogenomics of Membrane Transporters
    NIH U19GM061390Apr 1, 2000 - Jun 30, 2015
    Role: Co-Investigator
    Pharmaceutical Sciences and Pharmacogenomics
    NIH T32GM007175Jul 1, 1982 - Jun 30, 2022
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis. bioRxiv. 2023 Oct 23. Wise C, Yu H, Khanshour AM, Ushiki A, Otomo N, Koike Y, Einarsdottir E, Fan Y, Antunes L, Kidane YH, Cornelia R, Sheng R, Zhang Y, Pei J, Grishin NV, Evers BMV, Cheung JPY, Herring JA, Terao C, Song YQ, Gurnett C, Gerdhem P, Ikegawa S, Rios JJ, Ahituv N. PMID: 37292598; PMCID: PMC10245954.
      View in: PubMed   Mentions: 1  
    2. Chromatin compartmentalization regulates the response to DNA damage. Nature. 2023 Oct 18. Arnould C, Rocher V, Saur F, Bader AS, Muzzopappa F, Collins S, Lesage E, Le Bozec B, Puget N, Clouaire T, Mangeat T, Mourad R, Ahituv N, Noordermeer D, Erdel F, Bushell M, Marnef A, Legube G. PMID: 37853125.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Best practices for perturbation MPRA-a computational evaluation framework of sequence design strategies. bioRxiv. 2023 Sep 29. Liu J, Ashuach T, Inoue F, Ahituv N, Yosef N, Kreimer A. PMID: 37808807; PMCID: PMC10557651.
      View in: PubMed   Mentions:
    4. Milk antibody response after 3rd COVID-19 vaccine and SARS-CoV-2 infection and implications for infant protection. iScience. 2023 Oct 20; 26(10):107767. Golan Y, Ilala M, Li L, Gay C, Hunagund S, Lin CY, Cassidy AG, Jigmeddagva U, Matsui Y, Ozarslan N, Asiodu IV, Ahituv N, Flaherman VJ, Gaw SL, Prahl M. PMID: 37731614; PMCID: PMC10507209.
      View in: PubMed   Mentions: 1  
    5. Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. bioRxiv. 2023 Aug 14. Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, PsychENCODE Consortium, Ahituv N, Abyzov A, Vaccarino FM. PMID: 37645832; PMCID: PMC10461976.
      View in: PubMed   Mentions:
    6. Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD. bioRxiv. 2023 Jun 07. Wang C, Derderian KD, Hamada E, Zhou X, Nelson AD, Kyoung H, Ahituv N, Bouvier G, Bender KJ. PMID: 37333267; PMCID: PMC10274749.
      View in: PubMed   Mentions:
    7. Three-dimensional genome rewiring in loci with human accelerated regions. Science. 2023 04 28; 380(6643):eabm1696. Keough KC, Whalen S, Inoue F, Przytycki PF, Fair T, Deng C, Steyert M, Ryu H, Lindblad-Toh K, Karlsson E, Zoonomia Consortium§, Nowakowski T, Ahituv N, Pollen A, Pollard KS. PMID: 37104607.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Quasi-prime peptides: identification of the shortest peptide sequences unique to a species. NAR Genom Bioinform. 2023 Jun; 5(2):lqad039. Mouratidis I, Chan CSY, Chantzi N, Tsiatsianis GC, Hemberg M, Ahituv N, Georgakopoulos-Soares I. PMID: 37101657; PMCID: PMC10124967.
      View in: PubMed   Mentions:
    9. Transcription factor binding site orientation and order are major drivers of gene regulatory activity. Nat Commun. 2023 04 22; 14(1):2333. Georgakopoulos-Soares I, Deng C, Agarwal V, Chan CSY, Zhao J, Inoue F, Ahituv N. PMID: 37087538; PMCID: PMC10122648.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality. bioRxiv. 2023 Apr 13. Ushiki A, Sheng RR, Zhang Y, Zhao J, Nobuhara M, Murray E, Ruan X, Rios JJ, Wise CA, Ahituv N. PMID: 37090618; PMCID: PMC10120660.
      View in: PubMed   Mentions:
    11. Abstract 991: Leveraging sequences missing from the human genome to detect cancer. Cancer Research. 2023 Apr 4; 83(7_Supplement):991-991. Barnea BO, Georgakopoulos-Soares GI, Ahituv AN, Chapman CJ, Hemberg HM, Mouratidis MI, Syrigos SK, Syrigos SN, Vathiotis VI, Mahajan MM, Panagiotou PE, Charpidou CA, Kvale KM, Chan CC, Easterlin ER. .
      View in: Publisher Site   Mentions:
    12. Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression. bioRxiv. 2023 Mar 29. Nguyen HP, Sheng R, Murray E, Ito Y, Bruck M, Biellak C, An K, Lynce F, Dillon DA, Magbanua MJM, Huppert LA, Hammerlindl H, Esserman L, Rosenbluth JM, Ahituv N. PMID: 37034710; PMCID: PMC10081280.
      View in: PubMed   Mentions:
    13. Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements. bioRxiv. 2023 Mar 28. Chardon FM, McDiarmid TA, Page NF, Martin B, Domcke S, Regalado SG, Lalanne JÆ, Calderon D, Starita LM, Sanders SJ, Ahituv N, Shendure J. PMID: 37034704; PMCID: PMC10081248.
      View in: PubMed   Mentions:
    14. TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function. bioRxiv. 2023 Mar 07. Okhovat M, VanCampen J, Lima AC, Nevonen KA, Layman CE, Ward S, Herrera J, Stendahl AM, Yang R, Harshman L, Li W, Sheng RR, Mao Y, Fedorov L, Ndjamen B, Vigh-Conrad KA, Matthews IR, Easow SA, Chan DK, Jan TA, Eichler EE, Rugonyi S, Conrad DF, Ahituv N, Carbone L. PMID: 36945527; PMCID: PMC10028908.
      View in: PubMed   Mentions:
    15. Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types. bioRxiv. 2023 Mar 06. Agarwal V, Inoue F, Schubach M, Martin BK, Dash PM, Zhang Z, Sohota A, Noble WS, Yardimci GG, Kircher M, Shendure J, Ahituv N. PMID: 36945371; PMCID: PMC10028905.
      View in: PubMed   Mentions:
    16. Genetic regulation of cell-type specific chromatin accessibility shapes the etiology of brain diseases. bioRxiv. 2023 Mar 02. Zeng B, Bendl J, Deng C, Lee D, Misir R, Reach SM, Kleopoulos SP, Auluck P, Marenco S, Lewis DA, Haroutunian V, Ahituv N, Fullard JF, Hoffman GE, Roussos P. PMID: 37090548; PMCID: PMC10120699.
      View in: PubMed   Mentions:
    17. Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex. bioRxiv. 2023 Feb 16. Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM, Pollen A, Nowakowski TJ, Ahituv N, Pollard KS. PMID: 36824845; PMCID: PMC9949039.
      View in: PubMed   Mentions:
    18. Integrative single-cell characterization of frugivory adaptations in the bat kidney and pancreas. bioRxiv. 2023 Feb 13. Gordon WE, Baek S, Nguyen HP, Kuo YM, Bradley R, Galazyuk A, Lee I, Ingala MR, Simmons NB, Schountz T, Cooper LN, Georgakopoulos-Soares I, Hemberg M, Ahituv N. PMID: 36824791; PMCID: PMC9949079.
      View in: PubMed   Mentions:
    19. Characterization of De Novo Promoter Variants in Autism Spectrum Disorder with Massively Parallel Reporter Assays. Int J Mol Sci. 2023 Feb 09; 24(4). Koesterich J, An JY, Inoue F, Sohota A, Ahituv N, Sanders SJ, Kreimer A. PMID: 36834916; PMCID: PMC9959321.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Risk scoring based on DNA methylation-driven related DEGs for colorectal cancer prognosis with systematic insights. Life Sci. 2023 Mar 01; 316:121413. Liu Z, Georgakopoulos-Soares I, Ahituv N, Wong KC. PMID: 36682524.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Machine learning dissection of human accelerated regions in primate neurodevelopment. Neuron. 2023 03 15; 111(6):857-873.e8. Whalen S, Inoue F, Ryu H, Fair T, Markenscoff-Papadimitriou E, Keough K, Kircher M, Martin B, Alvarado B, Elor O, Laboy Cintron D, Williams A, Hassan Samee MA, Thomas S, Krencik R, Ullian EM, Kriegstein A, Rubenstein JL, Shendure J, Pollen AA, Ahituv N, Pollard KS. PMID: 36640767; PMCID: PMC10023452.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Milk antibody response after 3rd dose of COVID-19 mRNA vaccine and SARS-CoV-2 breakthrough infection and implications for infant protection. medRxiv. 2022 Dec 14. Golan Y, Ilala M, Gay C, Hunagund S, Lin CY, Cassidy AG, Jigmeddagva U, Li L, Ozarslan N, Asiodu IV, Ahituv N, Flaherman VJ, Gaw SL, Prahl M. PMID: 36561188; PMCID: PMC9774223.
      View in: PubMed   Mentions:
    23. Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma. Cell Genom. 2023 Jan 11; 3(1):100229. Koh KD, Bonser LR, Eckalbar WL, Yizhar-Barnea O, Shen J, Zeng X, Hargett KL, Sun DI, Zlock LT, Finkbeiner WE, Ahituv N, Erle DJ. PMID: 36777184; PMCID: PMC9903679.
      View in: PubMed   Mentions: 1  
    24. Author Correction: High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation. Genome Biol. 2022 Jul 27; 23(1):164. Georgakopoulos-Soares I, Chan CSY, Ahituv N, Hemberg M. PMID: 35897074; PMCID: PMC9327390.
      View in: PubMed   Mentions:    Fields:    
    25. High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation. Genome Biol. 2022 07 18; 23(1):159. Georgakopoulos-Soares I, Chan CSY, Ahituv N, Hemberg M. PMID: 35851062; PMCID: PMC9290270.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis. Hum Mol Genet. 2022 07 07; 31(13):2279-2293. Choquet H, Li W, Yin J, Bradley R, Hoffmann TJ, Nandakumar P, 23 and Me Research Team, Mostaedi R, Tian C, Ahituv N, Jorgenson E. PMID: 35022708; PMCID: PMC9262393.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Cellular and transcriptional diversity over the course of human lactation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2121720119. Nyquist SK, Gao P, Haining TKJ, Retchin MR, Golan Y, Drake RS, Kolb K, Mead BE, Ahituv N, Martinez ME, Shalek AK, Berger B, Goods BA. PMID: 35377806; PMCID: PMC9169737.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation. Nat Commun. 2022 03 21; 13(1):1504. Kreimer A, Ashuach T, Inoue F, Khodaverdian A, Deng C, Yosef N, Ahituv N. PMID: 35315433; PMCID: PMC8938438.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    29. High-throughput characterization of the role of non-B DNA motifs on promoter function. Cell Genom. 2022 Apr 13; 2(4). Georgakopoulos-Soares I, Victorino J, Parada GE, Agarwal V, Zhao J, Wong HY, Umar MI, Elor O, Muhwezi A, An JY, Sanders SJ, Kwok CK, Inoue F, Hemberg M, Ahituv N. PMID: 35573091; PMCID: PMC9105345.
      View in: PubMed   Mentions: 8  
    30. COVID-19 mRNA Vaccination in Lactation: Assessment of Adverse Events and Vaccine Related Antibodies in Mother-Infant Dyads. Front Immunol. 2021; 12:777103. Golan Y, Prahl M, Cassidy AG, Gay C, Wu AHB, Jigmeddagva U, Lin CY, Gonzalez VJ, Basilio E, Chidboy MA, Warrier L, Buarpung S, Li L, Murtha AP, Asiodu IV, Ahituv N, Flaherman VJ, Gaw SL. PMID: 34804068; PMCID: PMC8595828.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCellsCTClinical Trials
    31. Oestrogen engages brain MC4R signalling to drive physical activity in female mice. Nature. 2021 11; 599(7883):131-135. Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA. PMID: 34646010; PMCID: PMC9113400.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    32. Single-cell epigenomics reveals mechanisms of human cortical development. Nature. 2021 10; 598(7879):205-213. Ziffra RS, Kim CN, Ross JM, Wilfert A, Turner TN, Haeussler M, Casella AM, Przytycki PF, Keough KC, Shin D, Bogdanoff D, Kreimer A, Pollard KS, Ament SA, Eichler EE, Ahituv N, Nowakowski TJ. PMID: 34616060; PMCID: PMC8494642.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    33. Evaluation of Messenger RNA From COVID-19 BTN162b2 and mRNA-1273 Vaccines in Human Milk. JAMA Pediatr. 2021 10 01; 175(10):1069-1071. Golan Y, Prahl M, Cassidy A, Lin CY, Ahituv N, Flaherman VJ, Gaw SL. PMID: 34228115; PMCID: PMC8261686.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    34. COVID-19 mRNA Vaccination in Lactation: Assessment of adverse events and vaccine related antibodies in mother-infant dyads. medRxiv. 2021 Sep 16. Golan Y, Prahl M, Cassidy AG, Gay C, Wu AHB, Jigmeddagva U, Lin CY, Gonzalez VJ, Basilio E, Warrier L, Buarpung S, Li L, Murtha AP, Asiodu IV, Ahituv N, Flaherman VJ, Gaw SL. PMID: 34373861; PMCID: PMC8351783.
      View in: PubMed   Mentions:
    35. Absent from DNA and protein: genomic characterization of nullomers and nullpeptides across functional categories and evolution. Genome Biol. 2021 08 25; 22(1):245. Georgakopoulos-Soares I, Yizhar-Barnea O, Mouratidis I, Hemberg M, Ahituv N. PMID: 34433494; PMCID: PMC8386077.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    36. Author Correction: lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements. Nat Protoc. 2021 Jul; 16(7):3736. Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulos-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N. PMID: 33128032.
      View in: PubMed   Mentions: 1     Fields:    
    37. The cis-regulatory effects of modern human-specific variants. Elife. 2021 04 22; 10. Weiss CV, Harshman L, Inoue F, Fraser HB, Petrov DA, Ahituv N, Gokhman D. PMID: 33885362; PMCID: PMC8062137.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    38. Deletion of CTCF sites in the SHH locus alters enhancer-promoter interactions and leads to acheiropodia. Nat Commun. 2021 04 16; 12(1):2282. Ushiki A, Zhang Y, Xiong C, Zhao J, Georgakopoulos-Soares I, Kane L, Jamieson K, Bamshad MJ, Nickerson DA, University of Washington Center for Mendelian Genomics, Shen Y, Lettice LA, Silveira-Lucas EL, Petit F, Ahituv N. PMID: 33863876; PMCID: PMC8052326.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    39. Publisher Correction: Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Nat Genet. 2021 Apr; 53(4):587. Gokhman D, Agoglia RM, Kinnebrew M, Gordon W, Sun D, Bajpai VK, Naqvi S, Chen C, Chan A, Chen C, Petrov DA, Ahituv N, Zhang H, Mishina Y, Wysocka J, Rohatgi R, Fraser HB. PMID: 33762754.
      View in: PubMed   Mentions:    Fields:    
    40. Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Nat Genet. 2021 04; 53(4):467-476. Gokhman D, Agoglia RM, Kinnebrew M, Gordon W, Sun D, Bajpai VK, Naqvi S, Chen C, Chan A, Chen C, Petrov DA, Ahituv N, Zhang H, Mishina Y, Wysocka J, Rohatgi R, Fraser HB. PMID: 33731941; PMCID: PMC8038968.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome. Hum Mol Genet. 2021 01 21; 29(22):3606-3615. Makki N, Zhao J, Liu Z, Eckalbar WL, Ushiki A, Khanshour AM, Wu J, Rios J, Gray RS, Wise CA, Ahituv N. PMID: 33179741; PMCID: PMC7823110.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. Asymmetron: a toolkit for the identification of strand asymmetry patterns in biological sequences. Nucleic Acids Res. 2021 01 11; 49(1):e4. Georgakopoulos-Soares I, Mouratidis I, Parada GE, Matharu N, Hemberg M, Ahituv N. PMID: 33211865; PMCID: PMC7797064.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    43. A systematic evaluation of the design and context dependencies of massively parallel reporter assays. Nat Methods. 2020 11; 17(11):1083-1091. Klein JC, Agarwal V, Inoue F, Keith A, Martin B, Kircher M, Ahituv N, Shendure J. PMID: 33046894; PMCID: PMC7727316.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    44. Modulating gene regulation to treat genetic disorders. Nat Rev Drug Discov. 2020 11; 19(11):757-775. Matharu N, Ahituv N. PMID: 33020616.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    45. Co-option of the lineage-specific LAVA retrotransposon in the gibbon genome. Proc Natl Acad Sci U S A. 2020 08 11; 117(32):19328-19338. Okhovat M, Nevonen KA, Davis BA, Michener P, Ward S, Milhaven M, Harshman L, Sohota A, Fernandes JD, Salama SR, O'Neill RJ, Ahituv N, Veeramah KR, Carbone L. PMID: 32690705; PMCID: PMC7431028.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements. Nat Protoc. 2020 08; 15(8):2387-2412. Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulos-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N. PMID: 32641802; PMCID: PMC7550205.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    47. Noncoding SNPs associated with increased GDF15 levels located in a metformin-activated enhancer region upstream of GDF15. Pharmacogenomics. 2020 06; 21(8):509-520. Linhares ND, Pereira DA, Conceição IM, Franco GR, Eckalbar WL, Ahituv N, Luizon MR. PMID: 32427048.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. The cartilage matrisome in adolescent idiopathic scoliosis. Bone Res. 2020; 8:13. Wise CA, Sepich D, Ushiki A, Khanshour AM, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N, Solnica-Krezel L. PMID: 32195011; PMCID: PMC7062733.
      View in: PubMed   Mentions: 10  
    49. Characterization of functional transposable element enhancers in acute myeloid leukemia. Sci China Life Sci. 2020 May; 63(5):675-687. Zeng Y, Cao Y, Halevy RS, Nguyen P, Liu D, Zhang X, Ahituv N, Han JJ. PMID: 32170627.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    50. Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha. Mol Biol Evol. 2019 12 01; 36(12):2805-2812. Hardin A, Nevonen KA, Eckalbar WL, Carbone L, Ahituv N. PMID: 31424545; PMCID: PMC6878952.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    51. Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice. PLoS Genet. 2019 10; 15(10):e1008096. Liu Z, Easson GWD, Zhao J, Makki N, Ahituv N, Hilton MJ, Tang SY, Gray RS. PMID: 31652254; PMCID: PMC6834287.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    52. Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction. Cell Stem Cell. 2019 Nov 07; 25(5):713-727.e10. Inoue F, Kreimer A, Ashuach T, Ahituv N, Yosef N. PMID: 31631012; PMCID: PMC6850896.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    53. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. . 2019 Sep 12. N NM, S SR, S ST, L LM, Y YW, A AB, A AH, WL WE, C CV, N NA. .
      View in: Publisher Site   Mentions:
    54. MPRAnalyze: statistical framework for massively parallel reporter assays. Genome Biol. 2019 09 02; 20(1):183. Ashuach T, Fischer DS, Kreimer A, Ahituv N, Theis FJ, Yosef N. PMID: 31477158; PMCID: PMC6717970.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
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    128. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct; 19(10):770-80. Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. PMID: 19745787; PMCID: PMC2976711.
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    129. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. PMID: 19842929; PMCID: PMC2923222.
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    130. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). J Pharmacol Exp Ther. 2009 Mar; 328(3):699-707. Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. PMID: 19098160; PMCID: PMC2682268.
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    131. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009 Mar 15; 18(6):1140-7. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. PMID: 19091795; PMCID: PMC2649015.
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    135. In vivo characterization of human APOA5 haplotypes. Genomics. 2007 Dec; 90(6):674-9. Ahituv N, Akiyama J, Chapman-Helleboid A, Fruchart J, Pennacchio LA. PMID: 17936576.
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    136. Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle. PLoS One. 2007 Sep 19; 2(9):e903. Costford SR, Kavaslar N, Ahituv N, Chaudhry SN, Schackwitz WS, Dent R, Pennacchio LA, McPherson R, Harper ME. PMID: 17878938; PMCID: PMC1964808.
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    139. In vivo enhancer analysis of human conserved non-coding sequences. Nature. 2006 Nov 23; 444(7118):499-502. Pennacchio LA, Ahituv N, Moses AM, Prabhakar S, Nobrega MA, Shoukry M, Minovitsky S, Dubchak I, Holt A, Lewis KD, Plajzer-Frick I, Akiyama J, De Val S, Afzal V, Black BL, Couronne O, Eisen MB, Visel A, Rubin EM. PMID: 17086198.
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    140. A distal enhancer and an ultraconserved exon are derived from a novel retroposon. Nature. 2006 May 04; 441(7089):87-90. Bejerano G, Lowe CB, Ahituv N, King B, Siepel A, Salama SR, Rubin EM, Kent WJ, Haussler D. PMID: 16625209.
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    141. A PYY Q62P variant linked to human obesity. Hum Mol Genet. 2006 Feb 01; 15(3):387-91. Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Collier JM, Hébert S, Doelle H, Dent R, Pennacchio LA, McPherson R. PMID: 16368708.
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    142. Mapping cis-regulatory domains in the human genome using multi-species conservation of synteny. Hum Mol Genet. 2005 Oct 15; 14(20):3057-63. Ahituv N, Prabhakar S, Poulin F, Rubin EM, Couronne O. PMID: 16155111.
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    143. Comparative genomic analysis reveals a distant liver enhancer upstream of the COUP-TFII gene. Mamm Genome. 2005 Feb; 16(2):91-5. Baroukh N, Ahituv N, Chang J, Shoukry M, Afzal V, Rubin EM, Pennacchio LA. PMID: 15859353.
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    144. Exploiting human--fish genome comparisons for deciphering gene regulation. Hum Mol Genet. 2004 Oct 01; 13 Spec No 2:R261-6. Ahituv N, Rubin EM, Nobrega MA. PMID: 15358733.
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    145. An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome. 2004 Jun; 15(6):424-32. Ahituv N, Erven A, Fuchs H, Guy K, Ashery-Padan R, Williams T, de Angelis MH, Avraham KB, Steel KP. PMID: 15181535.
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    146. Myosin VI. Genetic Hearing Loss. 2003 Oct 17. Ahituv AN, Ben-David BO, Gasparini GP, Avraham AK. .
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    148. MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss. Am J Hum Genet. 2001 Sep; 69(3):635-40. Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M, Zelante L, Estivill X, Avraham KB, Gasparini P. PMID: 11468689; PMCID: PMC1235492.
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    149. The Notch ligand Jagged1 is required for inner ear sensory development. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3873-8. Kiernan AE, Ahituv N, Fuchs H, Balling R, Avraham KB, Steel KP, Hrabé de Angelis M. PMID: 11259677; PMCID: PMC31145.
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    150. Genomic structure of the human unconventional myosin VI gene. Gene. 2000 Dec 31; 261(2):269-75. Ahituv N, Sobe T, Robertson NG, Morton CC, Taggart RT, Avraham KB. PMID: 11167014.
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    151. Auditory and vestibular mouse mutants: models for human deafness. J Basic Clin Physiol Pharmacol. 2000; 11(3):181-91. Ahituv N, Avraham KB. PMID: 11041382.
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    152. Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. Science. 1998 Mar 20; 279(5358):1950-4. Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB. PMID: 9506947.
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    153. Devising a cooperation policy for emergency networks. J Oper Res Soc. 1987 Nov; 38(11):1015-29. Ahituv N, Berman O. PMID: 10302092.
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