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Mark Ansel, PhD

Title(s)Professor, Microbiology and Immunology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-5368
ORCID ORCID Icon0000-0003-4840-9879 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.2001 Graduate Division (Biomedical Sciences)

    Collapse Overview 
    Collapse Overview
    MicroRNAs, transcription factors, and epigenetic regulation shape the gene expression programs that determine cell identity and function. The Ansel lab studies how these molecular mechanisms work together to control lymphocyte development, differentiation, and function in immunity.

    We use in vitro cell differentiation systems, mouse genetics, disease models, and high dimensional cellular and molecular analyses in human biospecimens to unravel the regulatory networks that underlie immunity and immune pathology, especially allergy and asthma.

    Lymphocyte lineage decisions and the deployment of their effector functions are critical for the development of protective immunity against a great diversity of pathogens. However, improper or exaggerated responses underlie the pathogenesis of autoimmune diseases, chronic inflammation, allergy, and asthma. Our primary experimental system is the differentiation of helper T cells, the central coordinators of adaptive immune responses. Upon immune activation, naïve CD4+ T cells can differentiate into several different helper T cell effectors subtypes (e.g. Th1, Th2, Th17, iTreg, Tfh, etc.). These lineages are defined by their characteristic gene expression programs and mediate distinct immune functions. These gene expression programs are controlled by external factors that derive from other cells or the environment, signaling-induced and lineage-specific transcription factors, epigenetic regulation of transcriptional responses, and posttranscriptional mechanisms, including RNA-binding proteins and miRNAs. The depth of our knowledge about the networks that control helper T cells makes them an attractive model for studying basic mechanisms of gene regulation.

    Active projects in the laboratory mostly focus on RNA regulation of immune cell programming. We study how individual miRNA families regulate lymphocyte differentiation and immune function, and the regulation of the miRNA pathway itself during immune responses. Naive CD4+ T cells that cannot produce any miRNAs exhibit reduced cell division and survival in response to immune stimuli. Surprisingly, they also undergo rapid unrestrained differentiation into effector cells. We have developed a screening technology that allows us to rapidly determine which specific miRNAs regulate each of these T cell behaviors, and pipelines for determining miRNA expression patterns in very small clinical samples (such as sorted T cell subsets from the airways of human asthmatic subjects, serum, sputum, and other sources of extracellular miRNAs, etc.). In addition, we discovered that T cells rapidly reset their small RNA repertoire upon activation. This process involves ubiquitination and degradation of Argonaute proteins and the release of RNAs in extracellular vesicles, but the signaling mechanisms and the fate of associated RNAs remains unknown. Activation-induced changes in regulatory RNA expression affects T cell differentiation and the development of immune effector functions.

    The major research goals of our laboratory are:

    1) To define the molecular mechanisms that control miRNA homeostasis and extracellular release by lymphocytes, and determine how the miRNA repertoire is so dramatically remodeled during activation.

    2) To characterize the function of RBPs and individual miRNAs that regulate T cell differentiation and immune effector functions.

    3) To determine how the expression and function of miRNAs contributes to the pathogenic properties of T cells and other immune cells in human asthma.



    Collapse Research 
    Collapse Research Activities and Funding
    Predoctrol Training in Biomedical Sciences
    NIH T32GM136547Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Global analysis of T cell post-transcriptional regulatory elements
    NIH R21AI128047May 10, 2018 - Apr 30, 2020
    Role: Principal Investigator
    In Vivo Regulated Release and Function of Extracellular Small RNAs
    NIH/NCI U19CA179512Sep 1, 2013 - Aug 31, 2018
    Role: Co-Investigator
    Exploring the biology of persistent type 2 airway niches in asthma
    NIH 2P01HL107202-06A1Aug 15, 2012 - Jul 31, 2024
    Role: Leader, Project 2: MicroRNA networks in persistent type 2 airway niches in asthma
    MicroRNA directed pathway discovery in helper T cell driven airway inflammation
    NIH R01HL109102Aug 1, 2011 - Mar 31, 2020
    Role: Principal Investigator
    Predoctoral Training in Biomedical Sciences
    NIH/NIGMS T32GM008568Jul 1, 1995 - Mar 31, 2005
    Role: Principal Investigator

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing. Nat Commun. 2020 Sep 04; 11(1):4499. Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S. PMID: 32887888.
      View in: PubMed   Mentions:    Fields:    
    2. Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing. Nat Commun. 2020 06 19; 11(1):3126. Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S. PMID: 32561710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells. Clin Exp Allergy. 2020 Jun 15. Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Mark Ansel K, Youngblood BA, Fahy JV. PMID: 32542913.
      View in: PubMed   Mentions:    Fields:    
    4. Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma. J Allergy Clin Immunol. 2020 Apr 13. Durack J, Christian LS, Nariya S, Gonzalez J, Bhakta NR, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Peters SP, Rosenberg SR, Sorkness CA, Wechsler ME, Wenzel SE, White SR, Lynch SV, Boushey HA, Huang YJ. PMID: 32298699.
      View in: PubMed   Mentions:    Fields:    
    5. Universal Principled Review: A Community-Driven Method to Improve Peer Review. Cell. 2019 Dec 12; 179(7):1441-1445. Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M. PMID: 31835023.
      View in: PubMed   Mentions: 1     Fields:    
    6. RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. Cell Rep. 2019 09 10; 28(11):2795-2806.e3. Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW. PMID: 31509743.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. MicroRNA regulation of CD8+ T cell responses. Noncoding RNA Investig. 2019 Aug; 3. Gagnon JD, Ansel KM. PMID: 31844841.
      View in: PubMed   Mentions:
    8. miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. PMID: 31433990.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. Immunohorizons. 2019 08 19; 3(8):389-401. Wigton EJ, DeFranco AL, Ansel KM. PMID: 31427364.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization. Genome Res. 2019 06; 29(6):896-906. Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM. PMID: 31152051.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 04 04; 177(2):231-242. Das S, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC. PMID: 30951667.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses. Cell Rep. 2019 01 22; 26(4):933-944.e4. Pua HH, Happ HC, Gray CJ, Mar DJ, Chiou NT, Hesse LE, Ansel KM. PMID: 30673615.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    13. Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation. Cell Rep. 2018 12 18; 25(12):3356-3370.e4. Chiou NT, Kageyama R, Ansel KM. PMID: 30566862.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Bacterial biogeography of adult airways in atopic asthma. Microbiome. 2018 06 09; 6(1):104. Durack J, Huang YJ, Nariya S, Christian LS, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, King TS, White SR, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Peters SP, Smith LJ, Wechsler ME, Lynch SV, Boushey HA. PMID: 29885665.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    15. Identification of Functionally Relevant microRNAs in the Regulation of Allergic Inflammation. Methods Mol Biol. 2018; 1799:341-351. Fassett MS, Pua HH, Simpson LJ, Steiner DF, Ansel KM. PMID: 29956162.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 2017 Dec 04; 214(12):3627-3643. Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM. PMID: 29122948.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2017 09 07; 549(7670):111-115. Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. PMID: 28854172.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    18. A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation. J Immunol. 2017 07 15; 199(2):559-569. Montoya MM, Maul J, Singh PB, Pua HH, Dahlström F, Wu N, Huang X, Ansel KM, Baumjohann D. PMID: 28607111.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation. J Vis Exp. 2017 04 13; (122). Montoya MM, Ansel KM. PMID: 28448060.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8765-70. Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. PMID: 27432971.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    21. IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 06 01; 193(11):1281-91. Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. PMID: 26649486.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    22. MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19; 44(4):821-32. Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM. PMID: 26850657.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    23. Biogenesis, delivery, and function of extracellular RNA. J Extracell Vesicles. 2015; 4:27494. Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT. PMID: 26320939.
      View in: PubMed   Mentions:
    24. MicroRNA regulation of allergic inflammation and asthma. Curr Opin Immunol. 2015 Oct; 36:101-8. Pua HH, Ansel KM. PMID: 26253882.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    25. mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. J Immunol. 2015 Aug 15; 195(4):1470-9. Schaffert SA, Loh C, Wang S, Arnold CP, Axtell RC, Newell EW, Nolan G, Ansel KM, Davis MM, Steinman L, Chen CZ. PMID: 26163591.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    26. MicroRNA regulation of lymphocyte tolerance and autoimmunity. J Clin Invest. 2015 Jun; 125(6):2242-9. Simpson LJ, Ansel KM. PMID: 26030228.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    27. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 09; 27(3):409-25. Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. PMID: 25759025.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    28. Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation. EMBO J. 2015 May 05; 34(9):1195-213. Warth SC, Hoefig KP, Hiekel A, Schallenberg S, Jovanovic K, Klein L, Kretschmer K, Ansel KM, Heissmeyer V. PMID: 25712478.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. The transcription factor NFAT promotes exhaustion of activated CD8? T cells. Immunity. 2015 Feb 17; 42(2):265-278. Martinez GJ, Pereira RM, Äijö T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lähdesmäki H, Hogan PG, Rao A. PMID: 25680272.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    30. Tracking early T follicular helper cell differentiation in vivo. Methods Mol Biol. 2015; 1291:27-38. Baumjohann D, Ansel KM. PMID: 25836299.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    31. Editorial overview: Allergy and hypersensitivity. Curr Opin Immunol. 2014 Dec; 31:ix-xi. Sperling AI, Ansel KM. PMID: 25456768.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    32. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70. Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. PMID: 25362490.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    33. Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nat Immunol. 2014 Aug; 15(8):777-88. Seumois G, Chavez L, Gerasimova A, Lienhard M, Omran N, Kalinke L, Vedanayagam M, Ganesan AP, Chawla A, Djukanovic R, Ansel KM, Peters B, Rao A, Vijayanand P. PMID: 24997565.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    34. Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways. Trends Genet. 2014 Jul; 30(7):298-307. Thomas MF, L'Etoile ND, Ansel KM. PMID: 24929628.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    35. MicroRNA regulation of the germinal center response. Curr Opin Immunol. 2014 Jun; 28:6-11. Baumjohann D, Ansel KM. PMID: 24530656.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014 Jan; 15(1):98-108. Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, Kim SJ, Zeng R, Dent A, Ansel KM, Diamond B, Hadeiba H, Butcher EC. PMID: 24292363.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    37. MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol. 2013 Sep; 13(9):666-78. Baumjohann D, Ansel KM. PMID: 23907446.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    38. The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8. Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. PMID: 23812098.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    39. Regulation of miRNA biogenesis and turnover in the immune system. Immunol Rev. 2013 May; 253(1):304-16. Bronevetsky Y, Ansel KM. PMID: 23550654.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    40. RNA regulation of the immune system. Immunol Rev. 2013 May; 253(1):5-11. Ansel KM. PMID: 23550634.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    41. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013 Mar 21; 38(3):596-605. Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F. PMID: 23499493.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    42. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11; 210(2):417-32. Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM. PMID: 23382546.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    43. Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol. 2013 Jan; 20(1):73-81. Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V. PMID: 23202588.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    44. An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol. 2012 Nov 30; 1(2):70-89. Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM. PMID: 23304658.
      View in: PubMed   Mentions:
    45. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74. Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. PMID: 22955319.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCellsCTClinical Trials
    46. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012 Jul 05; 120(1):130-42. Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM. PMID: 22613798.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    47. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity. 2012 Feb 24; 36(2):175-87. Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM. PMID: 22326582.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    48. MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81. Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM. PMID: 21820330.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    49. Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol. 2011 Sep 01; 187(5):2089-92. Baumjohann D, Okada T, Ansel KM. PMID: 21804014.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    50. Induction and maintenance of IL-4 expression are regulated differently by the 3' enhancer in CD4 T cells. J Immunol. 2011 Mar 01; 186(5):2792-9. Sofi MH, Qiao Y, Ansel KM, Kubo M, Chang CH. PMID: 21282512.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    51. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb 12; 6(2):e1000764. Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ. PMID: 20169186.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    52. Construction of small RNA cDNA libraries for deep sequencing. Methods Mol Biol. 2010; 667:93-111. Thomas MF, Ansel KM. PMID: 20827529.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    53. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol. 2008 May; 15(5):523-30. Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V. PMID: 18438418.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    54. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol. 2007 Oct 15; 179(8):5099-108. Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. PMID: 17911595.
      View in: PubMed   Mentions: 260     Fields:    Translation:AnimalsCells
    55. The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. Cell Cycle. 2007 Jul 15; 6(14):1789-95. Carvalho LD, Teixeira LK, Carrossini N, Caldeira AT, Ansel KM, Rao A, Viola JP. PMID: 17637565.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    56. Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27; 316(5824):604-8. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. PMID: 17463289.
      View in: PubMed   Mentions: 620     Fields:    Translation:AnimalsCells
    57. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol. 2007 Feb; 8(2):145-53. Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. PMID: 17195845.
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    58. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol. 2006; 24:607-56. Ansel KM, Djuretic I, Tanasa B, Rao A. PMID: 16551261.
      View in: PubMed   Mentions: 266     Fields:    Translation:HumansAnimalsCells
    59. MicroRNA profiling of the murine hematopoietic system. Genome Biol. 2005; 6(8):R71. Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. PMID: 16086853.
      View in: PubMed   Mentions: 159     Fields:    Translation:Animals
    60. Aberrant T cell differentiation in the absence of Dicer. J Exp Med. 2005 Jul 18; 202(2):261-9. Muljo SA, Ansel KM, Kanellopoulou C, Livingston DM, Rao A, Rajewsky K. PMID: 16009718.
      View in: PubMed   Mentions: 260     Fields:    Translation:AnimalsCells
    61. A plague of autoantibodies. Nat Immunol. 2005 Jul; 6(7):642-4. Heissmeyer V, Ansel KM, Rao A. PMID: 15991362.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    62. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity. 2005 Apr; 22(4):439-50. Kabashima K, Banks TA, Ansel KM, Lu TT, Ware CF, Cyster JG. PMID: 15845449.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    63. Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes. Novartis Found Symp. 2005; 271:179-87; discussion 187-90, 198-9. Monticelli S, Ansel KM, Lee DU, Rao A. PMID: 16605135.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    64. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec; 5(12):1251-9. Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. PMID: 15516924.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    65. Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA. Nat Immunol. 2004 Aug; 5(8):768-74. Nardone J, Lee DU, Ansel KM, Rao A. PMID: 15282556.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    66. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004 Sep; 5(9):943-52. Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG. PMID: 15300245.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    67. An epigenetic view of helper T cell differentiation. Nat Immunol. 2003 Jul; 4(7):616-23. Ansel KM, Lee DU, Rao A. PMID: 12830136.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    68. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med. 2003 May 05; 197(9):1191-8. Luther SA, Ansel KM, Cyster JG. PMID: 12732660.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    69. CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity. 2002 Jan; 16(1):67-76. Ansel KM, Harris RB, Cyster JG. PMID: 11825566.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    70. Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41. Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. PMID: 12405185.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    71. Chemokines in lymphopoiesis and lymphoid organ development. Curr Opin Immunol. 2001 Apr; 13(2):172-9. Ansel KM, Cyster JG. PMID: 11228410.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    72. Follicular stromal cells and lymphocyte homing to follicles. Immunol Rev. 2000 Aug; 176:181-93. Cyster JG, Ansel KM, Reif K, Ekland EH, Hyman PL, Tang HL, Luther SA, Ngo VN. PMID: 11043777.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    73. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 2000 Jul 20; 406(6793):309-14. Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG. PMID: 10917533.
      View in: PubMed   Mentions: 360     Fields:    Translation:AnimalsCells
    74. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med. 1999 Oct 18; 190(8):1123-34. Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. PMID: 10523610.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    75. Chemokines and B-cell homing to follicles. Curr Top Microbiol Immunol. 1999; 246:87-92; discussion 93. Cyster JG, Ngo VN, Ekland EH, Gunn MD, Sedgwick JD, Ansel KM. PMID: 10396043.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    76. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature. 1998 Feb 19; 391(6669):799-803. Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT. PMID: 9486651.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
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