Mark Ansel, PhD
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Title(s) | Professor, Microbiology and Immunology |
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School | School of Medicine |
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Address | 513 Parnassus Ave, HSE San Francisco CA 94143
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Phone | 415-476-5368 |
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ORCID
.gif) | 0000-0003-4840-9879  |
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vCard | Download vCard |
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Biography University of California, San Francisco | Ph.D. | 2001 | Graduate Division (Biomedical Sciences) | University of California, San Francisco, CA | | 12/2020 | Diversity, Equity, and Inclusion Champion Training |
Overview MicroRNAs, transcription factors, and epigenetic regulation shape the gene expression programs that determine cell identity and function. The Ansel lab studies how these molecular mechanisms work together to control lymphocyte development, differentiation, and function in immunity.
We use in vitro cell differentiation systems, mouse genetics, disease models, and high dimensional cellular and molecular analyses in human biospecimens to unravel the regulatory networks that underlie immunity and immune pathology, especially allergy and asthma.
Lymphocyte lineage decisions and the deployment of their effector functions are critical for the development of protective immunity against a great diversity of pathogens. However, improper or exaggerated responses underlie the pathogenesis of autoimmune diseases, chronic inflammation, allergy, and asthma. Our primary experimental system is the differentiation of helper T cells, the central coordinators of adaptive immune responses. Upon immune activation, naïve CD4+ T cells can differentiate into several different helper T cell effectors subtypes (e.g. Th1, Th2, Th17, iTreg, Tfh, etc.). These lineages are defined by their characteristic gene expression programs and mediate distinct immune functions. These gene expression programs are controlled by external factors that derive from other cells or the environment, signaling-induced and lineage-specific transcription factors, epigenetic regulation of transcriptional responses, and posttranscriptional mechanisms, including RNA-binding proteins and miRNAs. The depth of our knowledge about the networks that control helper T cells makes them an attractive model for studying basic mechanisms of gene regulation.
Active projects in the laboratory mostly focus on RNA regulation of immune cell programming. We study how individual miRNA families regulate lymphocyte differentiation and immune function, and the regulation of the miRNA pathway itself during immune responses. Naive CD4+ T cells that cannot produce any miRNAs exhibit reduced cell division and survival in response to immune stimuli. Surprisingly, they also undergo rapid unrestrained differentiation into effector cells. We have developed a screening technology that allows us to rapidly determine which specific miRNAs regulate each of these T cell behaviors, and pipelines for determining miRNA expression patterns in very small clinical samples (such as sorted T cell subsets from the airways of human asthmatic subjects, serum, sputum, and other sources of extracellular miRNAs, etc.). In addition, we discovered that T cells rapidly reset their small RNA repertoire upon activation. This process involves ubiquitination and degradation of Argonaute proteins and the release of RNAs in extracellular vesicles, but the signaling mechanisms and the fate of associated RNAs remains unknown. Activation-induced changes in regulatory RNA expression affects T cell differentiation and the development of immune effector functions.
The major research goals of our laboratory are:
1) To define the molecular mechanisms that control miRNA homeostasis and extracellular release by lymphocytes, and determine how the miRNA repertoire is so dramatically remodeled during activation.
2) To characterize the function of RBPs and individual miRNAs that regulate T cell differentiation and immune effector functions.
3) To determine how the expression and function of miRNAs contributes to the pathogenic properties of T cells and other immune cells in human asthma.
Research ORNG Applications Bibliographic
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COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14.
Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C. PMID: 33469573.
View in: PubMed Mentions:
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miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling. Cell Rep. 2020 Dec 01; 33(9):108436.
Hines MJ, Coffre M, Mudianto T, Panduro M, Wigton EJ, Tegla C, Osorio-Vasquez V, Kageyama R, Benhamou D, Perez O, Bajwa S, McManus MT, Ansel KM, Melamed D, Koralov SB. PMID: 33264610.
View in: PubMed Mentions: Fields:
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Author Correction: Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing. Nat Commun. 2020 09 04; 11(1):4499.
Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S. PMID: 32887888.
View in: PubMed Mentions: Fields:
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An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells. Clin Exp Allergy. 2020 Aug; 50(8):904-914.
Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV. PMID: 32542913.
View in: PubMed Mentions: 1 Fields:
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Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing. Nat Commun. 2020 06 19; 11(1):3126.
Mandric I, Rotman J, Yang HT, Strauli N, Montoya DJ, Van Der Wey W, Ronas JR, Statz B, Yao D, Petrova V, Zelikovsky A, Spreafico R, Shifman S, Zaitlen N, Rossetti M, Ansel KM, Eskin E, Mangul S. PMID: 32561710.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma. J Allergy Clin Immunol. 2020 Nov; 146(5):1016-1026.
Durack J, Christian LS, Nariya S, Gonzalez J, Bhakta NR, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Peters SP, Rosenberg SR, Sorkness CA, Wechsler ME, Wenzel SE, White SR, Lynch SV, Boushey HA, Huang YJ. PMID: 32298699.
View in: PubMed Mentions: Fields:
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Universal Principled Review: A Community-Driven Method to Improve Peer Review. Cell. 2019 Dec 12; 179(7):1441-1445.
Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M. PMID: 31835023.
View in: PubMed Mentions: 1 Fields:
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RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. Cell Rep. 2019 09 10; 28(11):2795-2806.e3.
Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW. PMID: 31509743.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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MicroRNA regulation of CD8+ T cell responses. Noncoding RNA Investig. 2019 Aug; 3.
Gagnon JD, Ansel KM. PMID: 31844841.
View in: PubMed Mentions:
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miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4.
Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. PMID: 31433990.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. Immunohorizons. 2019 08 19; 3(8):389-401.
Wigton EJ, DeFranco AL, Ansel KM. PMID: 31427364.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization. Genome Res. 2019 06; 29(6):896-906.
Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM. PMID: 31152051.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 04 04; 177(2):231-242.
Das S, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC. PMID: 30951667.
View in: PubMed Mentions: 21 Fields: Translation: HumansCells
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Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses. Cell Rep. 2019 01 22; 26(4):933-944.e4.
Pua HH, Happ HC, Gray CJ, Mar DJ, Chiou NT, Hesse LE, Ansel KM. PMID: 30673615.
View in: PubMed Mentions: 8 Fields: Translation: Animals
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Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation. Cell Rep. 2018 12 18; 25(12):3356-3370.e4.
Chiou NT, Kageyama R, Ansel KM. PMID: 30566862.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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Bacterial biogeography of adult airways in atopic asthma. Microbiome. 2018 06 09; 6(1):104.
Durack J, Huang YJ, Nariya S, Christian LS, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, King TS, White SR, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Peters SP, Smith LJ, Wechsler ME, Lynch SV, Boushey HA. PMID: 29885665.
View in: PubMed Mentions: 24 Fields: Translation: HumansCells
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Identification of Functionally Relevant microRNAs in the Regulation of Allergic Inflammation. Methods Mol Biol. 2018; 1799:341-351.
Fassett MS, Pua HH, Simpson LJ, Steiner DF, Ansel KM. PMID: 29956162.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 2017 Dec 04; 214(12):3627-3643.
Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM. PMID: 29122948.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. 2017 09 07; 549(7670):111-115.
Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, Woo JM, Mitros T, Ray GJ, Curie GL, Naddaf N, Chu JS, Ma H, Boyer E, Van Gool F, Huang H, Liu R, Tobin VR, Schumann K, Daly MJ, Farh KK, Ansel KM, Ye CJ, Greenleaf WJ, Anderson MS, Bluestone JA, Chang HY, Corn JE, Marson A. PMID: 28854172.
View in: PubMed Mentions: 43 Fields: Translation: HumansAnimalsCells
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A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation. J Immunol. 2017 07 15; 199(2):559-569.
Montoya MM, Maul J, Singh PB, Pua HH, Dahlström F, Wu N, Huang X, Ansel KM, Baumjohann D. PMID: 28607111.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation. J Vis Exp. 2017 04 13; (122).
Montoya MM, Ansel KM. PMID: 28448060.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8765-70.
PMID: 27432971.
View in: PubMed Mentions: 36 Fields: Translation: HumansCells
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IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 06 01; 193(11):1281-91.
Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. PMID: 26649486.
View in: PubMed Mentions: 33 Fields: Translation: HumansCells
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MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19; 44(4):821-32.
PMID: 26850657.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Biogenesis, delivery, and function of extracellular RNA. J Extracell Vesicles. 2015; 4:27494.
PMID: 26320939.
View in: PubMed Mentions:
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MicroRNA regulation of allergic inflammation and asthma. Curr Opin Immunol. 2015 Oct; 36:101-8.
PMID: 26253882.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. J Immunol. 2015 Aug 15; 195(4):1470-9.
PMID: 26163591.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCellsPHPublic Health
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MicroRNA regulation of lymphocyte tolerance and autoimmunity. J Clin Invest. 2015 Jun; 125(6):2242-9.
PMID: 26030228.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimalsCells
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Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 09; 27(3):409-25.
PMID: 25759025.
View in: PubMed Mentions: 33 Fields: Translation: HumansCells
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Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation. EMBO J. 2015 May 05; 34(9):1195-213.
PMID: 25712478.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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The transcription factor NFAT promotes exhaustion of activated CD8? T cells. Immunity. 2015 Feb 17; 42(2):265-278.
PMID: 25680272.
View in: PubMed Mentions: 125 Fields: Translation: AnimalsCells
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Tracking early T follicular helper cell differentiation in vivo. Methods Mol Biol. 2015; 1291:27-38.
PMID: 25836299.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCellsPHPublic Health
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Editorial overview: Allergy and hypersensitivity. Curr Opin Immunol. 2014 Dec; 31:ix-xi.
PMID: 25456768.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70.
PMID: 25362490.
View in: PubMed Mentions: 66 Fields: Translation: HumansAnimalsCells
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Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nat Immunol. 2014 Aug; 15(8):777-88.
PMID: 24997565.
View in: PubMed Mentions: 56 Fields: Translation: HumansCells
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Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways. Trends Genet. 2014 Jul; 30(7):298-307.
PMID: 24929628.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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MicroRNA regulation of the germinal center response. Curr Opin Immunol. 2014 Jun; 28:6-11.
PMID: 24530656.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol. 2014 Jan; 15(1):98-108.
PMID: 24292363.
View in: PubMed Mentions: 78 Fields: Translation: HumansAnimalsCells
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MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol. 2013 Sep; 13(9):666-78.
PMID: 23907446.
View in: PubMed Mentions: 133 Fields: Translation: HumansAnimalsCells
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The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013 Aug; 14(8):840-8.
PMID: 23812098.
View in: PubMed Mentions: 83 Fields: Translation: AnimalsCells
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RNA regulation of the immune system. Immunol Rev. 2013 May; 253(1):5-11.
PMID: 23550634.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimals
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Regulation of miRNA biogenesis and turnover in the immune system. Immunol Rev. 2013 May; 253(1):304-16.
PMID: 23550654.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity. 2013 Mar 21; 38(3):596-605.
PMID: 23499493.
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T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013 Feb 11; 210(2):417-32.
PMID: 23382546.
View in: PubMed Mentions: 83 Fields: Translation: HumansAnimalsCells
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Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Nat Struct Mol Biol. 2013 Jan; 20(1):73-81.
PMID: 23202588.
View in: PubMed Mentions: 37 Fields: Translation: AnimalsCells
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An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol. 2012 Nov 30; 1(2):70-89.
PMID: 23304658.
View in: PubMed Mentions:
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Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74.
PMID: 22955319.
View in: PubMed Mentions: 88 Fields: Translation: HumansCellsCTClinical Trials
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Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012 Jul 05; 120(1):130-42.
PMID: 22613798.
View in: PubMed Mentions: 23 Fields: Translation: AnimalsCells
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Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity. 2012 Feb 24; 36(2):175-87.
PMID: 22326582.
View in: PubMed Mentions: 49 Fields: Translation: AnimalsCells
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MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity. 2011 Aug 26; 35(2):169-81.
PMID: 21820330.
View in: PubMed Mentions: 122 Fields: Translation: AnimalsCells
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Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol. 2011 Sep 01; 187(5):2089-92.
Baumjohann D, Okada T, Ansel KM. PMID: 21804014.
View in: PubMed Mentions: 89 Fields: Translation: AnimalsCells
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Induction and maintenance of IL-4 expression are regulated differently by the 3' enhancer in CD4 T cells. J Immunol. 2011 Mar 01; 186(5):2792-9.
PMID: 21282512.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb 12; 6(2):e1000764.
Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ. PMID: 20169186.
View in: PubMed Mentions: 118 Fields: Translation: AnimalsCells
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Construction of small RNA cDNA libraries for deep sequencing. Methods Mol Biol. 2010; 667:93-111.
Thomas MF, Ansel KM. PMID: 20827529.
View in: PubMed Mentions: 12 Fields: Translation: Cells
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Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol. 2008 May; 15(5):523-30.
Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V. PMID: 18438418.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol. 2007 Oct 15; 179(8):5099-108.
Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. PMID: 17911595.
View in: PubMed Mentions: 270 Fields: Translation: AnimalsCells
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The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. . 2007 Jul 15; 6(14):1789-95.
Carvalho LD, Teixeira LK, Carrossini N, Caldeira AT, Ansel KM, Rao A, Viola JP. PMID: 17637565.
View in: PubMed Mentions:
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Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27; 316(5824):604-8.
Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. PMID: 17463289.
View in: PubMed Mentions: 635 Fields: Translation: AnimalsCells
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Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol. 2007 Feb; 8(2):145-53.
Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. PMID: 17195845.
View in: PubMed Mentions: 201 Fields: Translation: HumansAnimalsCells
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Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol. 2006; 24:607-56.
Ansel KM, Djuretic I, Tanasa B, Rao A. PMID: 16551261.
View in: PubMed Mentions: 272 Fields: Translation: HumansAnimalsCells
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MicroRNA profiling of the murine hematopoietic system. Genome Biol. 2005; 6(8):R71.
Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. PMID: 16086853.
View in: PubMed Mentions: 169 Fields: Translation: Animals
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Aberrant T cell differentiation in the absence of Dicer. J Exp Med. 2005 Jul 18; 202(2):261-9.
Muljo SA, Ansel KM, Kanellopoulou C, Livingston DM, Rao A, Rajewsky K. PMID: 16009718.
View in: PubMed Mentions: 270 Fields: Translation: AnimalsCells
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A plague of autoantibodies. Nat Immunol. 2005 Jul; 6(7):642-4.
Heissmeyer V, Ansel KM, Rao A. PMID: 15991362.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity. 2005 Apr; 22(4):439-50.
Kabashima K, Banks TA, Ansel KM, Lu TT, Ware CF, Cyster JG. PMID: 15845449.
View in: PubMed Mentions: 116 Fields: Translation: AnimalsCells
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Regulation of gene expression in mast cells: micro-rNA expression and chromatin structural analysis of cytokine genes. Novartis Found Symp. 2005; 271:179-87; discussion 187-90, 198-9.
Monticelli S, Ansel KM, Lee DU, Rao A. PMID: 16605135.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec; 5(12):1251-9.
Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. PMID: 15516924.
View in: PubMed Mentions: 52 Fields: Translation: AnimalsCells
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Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004 Sep; 5(9):943-52.
Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG. PMID: 15300245.
View in: PubMed Mentions: 232 Fields: Translation: AnimalsCells
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Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA. Nat Immunol. 2004 Aug; 5(8):768-74.
Nardone J, Lee DU, Ansel KM, Rao A. PMID: 15282556.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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An epigenetic view of helper T cell differentiation. Nat Immunol. 2003 Jul; 4(7):616-23.
Ansel KM, Lee DU, Rao A. PMID: 12830136.
View in: PubMed Mentions: 142 Fields: Translation: HumansAnimalsCells
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Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med. 2003 May 05; 197(9):1191-8.
Luther SA, Ansel KM, Cyster JG. PMID: 12732660.
View in: PubMed Mentions: 79 Fields: Translation: AnimalsCells
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CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity. 2002 Jan; 16(1):67-76.
Ansel KM, Harris RB, Cyster JG. PMID: 11825566.
View in: PubMed Mentions: 152 Fields: Translation: AnimalsCells
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Traffic patterns of B cells and plasma cells. Adv Exp Med Biol. 2002; 512:35-41.
Cyster JG, Ansel KM, Ngo VN, Hargreaves DC, Lu TT. PMID: 12405185.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Chemokines in lymphopoiesis and lymphoid organ development. Curr Opin Immunol. 2001 Apr; 13(2):172-9.
Ansel KM, Cyster JG. PMID: 11228410.
View in: PubMed Mentions: 39 Fields: Translation: HumansAnimalsCells
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Follicular stromal cells and lymphocyte homing to follicles. Immunol Rev. 2000 Aug; 176:181-93.
Cyster JG, Ansel KM, Reif K, Ekland EH, Hyman PL, Tang HL, Luther SA, Ngo VN. PMID: 11043777.
View in: PubMed Mentions: 120 Fields: Translation: HumansAnimalsCells
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A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 2000 Jul 20; 406(6793):309-14.
Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG. PMID: 10917533.
View in: PubMed Mentions: 383 Fields: Translation: AnimalsCells
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In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med. 1999 Oct 18; 190(8):1123-34.
Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. PMID: 10523610.
View in: PubMed Mentions: 155 Fields: Translation: AnimalsCells
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Chemokines and B-cell homing to follicles. Curr Top Microbiol Immunol. 1999; 246:87-92; discussion 93.
Cyster JG, Ngo VN, Ekland EH, Gunn MD, Sedgwick JD, Ansel KM. PMID: 10396043.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature. 1998 Feb 19; 391(6669):799-803.
Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT. PMID: 9486651.
View in: PubMed Mentions: 195 Fields: Translation: HumansAnimalsCells
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Year | Publications |
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1998 | 1 | 1999 | 2 | 2000 | 2 | 2001 | 1 | 2002 | 2 | 2003 | 2 | 2004 | 3 | 2005 | 5 | 2006 | 2 | 2007 | 3 | 2008 | 1 | 2010 | 2 | 2011 | 3 | 2012 | 5 | 2013 | 7 | 2014 | 5 | 2015 | 8 | 2016 | 3 | 2017 | 4 | 2018 | 3 | 2019 | 8 | 2020 | 5 | 2021 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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Derived automatically from this person's publications.
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People in Profiles who have published with this person.
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People who share similar concepts with this person.
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