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Stephen Rosenthal, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentPediatrics
Address550 16th. Street
San Francisco CA 94158
Phone415-476-2266
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The Impact of Early Medical Treatment in Transgender Youth
    NIH/NICHD R01HD082554Aug 1, 2015 - Jun 30, 2020
    Role: Co-Principal Investigator
    IGFS AND SKELETAL MUSCLE CELL DIFFERENTIATION
    NIH/NIDDK R01DK044181Jun 1, 1998 - Mar 31, 2004
    Role: Principal Investigator
    IGF-II AND MUSCLE CELL DIFFERENTIATION
    NIH/NIDDK R29DK044181May 1, 1992 - Jun 30, 1997
    Role: Principal Investigator
    IMPAIRED SOMATOMEDIN RESPONSIVENESS AND GROWTH FAILURE
    NIH/NICHD K08HD000836Jun 1, 1988 - May 31, 1991
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vance SR, Deutsch MB, Rosenthal S, Buckelew SM. Enhancing Pediatric Trainees' and Students' Knowledge in Providing Care to Transgender Youth. J Adolesc Health. 2017 Jan 05. PMID: 28065519.
      View in: PubMed
    2. Olson-Kennedy J, Cohen-Kettenis PT, Kreukels BP, Meyer-Bahlburg HF, Garofalo R, Meyer W, Rosenthal S. Research priorities for gender nonconforming/transgender youth: gender identity development and biopsychosocial outcomes. Curr Opin Endocrinol Diabetes Obes. 2016 Apr; 23(2):172-9. PMID: 26825472.
      View in: PubMed
    3. Vance SR, Rosenthal S. Treating Transgender Youth: Pushing the Dialogue Forward. J Adolesc Health. 2015 Oct; 57(4):357-8. PMID: 26403838.
      View in: PubMed
    4. Bonifacio HJ, Rosenthal S. Gender Variance and Dysphoria in Children and Adolescents. Pediatr Clin North Am. 2015 Aug; 62(4):1001-16. PMID: 26210629.
      View in: PubMed
    5. Vance SR, Ehrensaft D, Rosenthal S. Author's Response. Pediatrics. 2015 May; 135(5):e1366-7. PMID: 25934902.
      View in: PubMed
    6. Vance SR, Halpern-Felsher BL, Rosenthal S. Health care providers' comfort with and barriers to care of transgender youth. J Adolesc Health. 2015 Feb; 56(2):251-3. PMID: 25620310.
      View in: PubMed
    7. Haller MJ, Gitelman SE, Gottlieb PA, Michels AW, Rosenthal S, Shuster JJ, Zou B, Brusko TM, Hulme MA, Wasserfall CH, Mathews CE, Atkinson MA, Schatz DA. Anti-thymocyte globulin/G-CSF treatment preserves ß cell function in patients with established type 1 diabetes. J Clin Invest. 2015 Jan; 125(1):448-55. PMID: 25500887; PMCID: PMC4382237.
      View in: PubMed, PubMed Central
    8. Rosenthal S. Approach to the patient: transgender youth: endocrine considerations. J Clin Endocrinol Metab. 2014 Dec; 99(12):4379-89. PMID: 25140398.
      View in: PubMed
    9. Vance SR, Ehrensaft D, Rosenthal S. Psychological and medical care of gender nonconforming youth. Pediatrics. 2014 Dec; 134(6):1184-92. PMID: 25404716.
      View in: PubMed
    10. Lazure P, Bartel RC, Biller BM, Molitch ME, Rosenthal S, Ross JL, Bernsten BD, Hayes SM. Contextualized analysis of a needs assessment using the Theoretical Domains Framework: a case example in endocrinology. BMC Health Serv Res. 2014; 14:319. PMID: 25060235; PMCID: PMC4123497.
      View in: PubMed, PubMed Central
    11. Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal S, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 2013 Feb; 56(2):391-400. PMID: 23086558; PMCID: PMC3537871.
      View in: PubMed, PubMed Central
    12. Sherer I, Rosenthal S, Ehrensaft D, Baum J. Child and Adolescent Gender Center: a multidisciplinary collaboration to improve the lives of gender nonconforming children and teens. Pediatr Rev. 2012 Jun; 33(6):273-5. PMID: 22659258.
      View in: PubMed
    13. Cheung CC, Cadnapaphornchai MA, Ranadive SA, Gitelman SE, Rosenthal S. Persistent elevation of urine aquaporin-2 during water loading in a child with nephrogenic syndrome of inappropriate antidiuresis (NSIAD) caused by a R137L mutation in the V2 vasopressin receptor. Int J Pediatr Endocrinol. 2012; 2012(1):3. PMID: 22325688; PMCID: PMC3299583.
      View in: PubMed, PubMed Central
    14. Ranadive SA, Rosenthal S. Pediatric disorders of water balance. Pediatr Clin North Am. 2011 Oct; 58(5):1271-80, xi-xii. PMID: 21981960; PMCID: PMC4624211.
      View in: PubMed, PubMed Central
    15. Aslan IR, Baca EA, Charlton RW, Rosenthal S. Respiratory syncytial virus infection as a precipitant of thyroid storm in a previously undiagnosed case of graves' disease in a prepubertal girl. Int J Pediatr Endocrinol. 2011; 2011:138903. PMID: 21603250; PMCID: PMC3198741.
      View in: PubMed, PubMed Central
    16. Rochdi MD, Vargas GA, Carpentier E, Oligny-Longpré G, Chen S, Kovoor A, Gitelman SE, Rosenthal S, von Zastrow M, Bouvier M. Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis: implications for treatments. Mol Pharmacol. 2010 May; 77(5):836-45. PMID: 20159941; PMCID: PMC2872969.
      View in: PubMed, PubMed Central
    17. Cho YH, Gitelman S, Rosenthal S, Ambler G. Long-term outcomes in a family with nephrogenic syndrome of inappropriate antidiuresis. Int J Pediatr Endocrinol. 2009; 2009:431527. PMID: 20148077; PMCID: PMC2817859.
      View in: PubMed, PubMed Central
    18. Ranadive SA, Rosenthal S. Pediatric disorders of water balance. Endocrinol Metab Clin North Am. 2009 Dec; 38(4):663-72. PMID: 19944286; PMCID: PMC4610141.
      View in: PubMed, PubMed Central
    19. Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal S, Miller WL, Vaisse C. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Clin Endocrinol (Oxf). 2009 Sep; 71(3):388-93. PMID: 19170711.
      View in: PubMed
    20. Bremer AA, Ranadive S, Conrad SC, Vallette-Kasic S, Rosenthal S. Isolated adrenocorticotropic hormone deficiency presenting as an acute neurologic emergency in a peripubertal girl. J Pediatr Endocrinol Metab. 2008 Aug; 21(8):799-803. PMID: 18825881.
      View in: PubMed
    21. Rosenthal S. Statement 4: therapy should be offered to children with idiopathic short stature (ISS) whose heights are < -2.25 standard deviation (SD) score. Pediatr Endocrinol Rev. 2008 Apr; 5 Suppl 3:847-52. PMID: 18438328.
      View in: PubMed
    22. Meyer GE, Chesler L, Liu D, Gable K, Maddux BA, Goldenberg DD, Youngren JF, Goldfine ID, Weiss WA, Matthay KK, Rosenthal S. Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. J Cell Biochem. 2007 Dec 15; 102(6):1529-41. PMID: 17486636; PMCID: PMC3001106.
      View in: PubMed, PubMed Central
    23. Rosenthal S, Cohen P, Clayton P, Backeljauw P, Bang P, Ten S. Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency. Pediatr Endocrinol Rev. 2007 May; 4 Suppl 2:252-71. PMID: 17581497.
      View in: PubMed
    24. Bremer AA, Feldman BJ, Iezza G, Clark OH, Rosenthal S. Report of a hürthle cell neoplasm in a peripubertal girl. Thyroid. 2007 Feb; 17(2):175-8. PMID: 17316121.
      View in: PubMed
    25. Rosenthal S, Feldman BJ, Vargas GA, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatr Endocrinol Rev. 2006 Dec; 4 Suppl 1:66-70. PMID: 17261972.
      View in: PubMed
    26. Gitelman SE, Feldman BJ, Rosenthal S. Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients. Am J Med. 2006 Jul; 119(7 Suppl 1):S54-8. PMID: 16843086.
      View in: PubMed
    27. Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal S, Gitelman SE. Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children. J Pediatr. 2006 Jan; 148(1):128-31. PMID: 16423613.
      View in: PubMed
    28. Feldman BJ, Rosenthal S, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE. Nephrogenic syndrome of inappropriate antidiuresis. N Engl J Med. 2005 May 5; 352(18):1884-90. PMID: 15872203.
      View in: PubMed
    29. Tiffin N, Adi S, Stokoe D, Wu NY, Rosenthal S. Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation. Endocrinology. 2004 Nov; 145(11):4991-6. PMID: 15489316.
      View in: PubMed
    30. Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, Hardin DS, Kemp SF, Lawson M, Radovick S, Rosenthal S, Silverman L, Speiser P. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr. 2003 Oct; 143(4):415-21. PMID: 14571209.
      View in: PubMed
    31. Adi S, Bin-Abbas B, Wu NY, Rosenthal S. Early stimulation and late inhibition of extracellular signal-regulated kinase 1/2 phosphorylation by IGF-I: a potential mechanism mediating the switch in IGF-I action on skeletal muscle cell differentiation. Endocrinology. 2002 Feb; 143(2):511-6. PMID: 11796505.
      View in: PubMed
    32. Adi S, Wu NY, Rosenthal S. Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin. Endocrinology. 2001 Jan; 142(1):498-501. PMID: 11145615.
      View in: PubMed
    33. Cheng ZQ, Adi S, Wu NY, Hsiao D, Woo EJ, Filvaroff EH, Gustafson TA, Rosenthal S. Functional inactivation of the IGF-I receptor delays differentiation of skeletal muscle cells. J Endocrinol. 2000 Oct; 167(1):175-82. PMID: 11018765.
      View in: PubMed
    34. Adi S, Cheng ZQ, Zhang PL, Wu NY, Mellon SH, Rosenthal S. Opposing early inhibitory and late stimulatory effects of insulin-like growth factor-I on myogenin gene transcription. J Cell Biochem. 2000 Jun 12; 78(4):617-26. PMID: 10861859.
      View in: PubMed
    35. Roll U, Turck CW, Gitelman SE, Rosenthal S, Nolte MS, Masharani U, Ziegler AG, Baekkeskov S. Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients. Diabetologia. 2000 May; 43(5):598-608. PMID: 10855535.
      View in: PubMed
    36. Devoe DJ, Miller WL, Conte FA, Kaplan SL, Grumbach MM, Rosenthal S, Wilson CB, Gitelman SE. Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing's disease. J Clin Endocrinol Metab. 1997 Oct; 82(10):3196-202. PMID: 9329338.
      View in: PubMed
    37. Rabinovici J, Cataldo NA, Dandekar P, Rosenthal S, Gargosky SE, Gesundheit N, Martin MC. Adjunctive growth hormone during ovarian hyperstimulation increases levels of insulin-like growth factor binding proteins in follicular fluid: a randomized, placebo-controlled, cross-over study. J Clin Endocrinol Metab. 1997 Apr; 82(4):1171-6. PMID: 9100591.
      View in: PubMed
    38. Hernández-Sánchez C, Werner H, Roberts CT, Woo EJ, Hum DW, Rosenthal S, LeRoith D. Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor. J Biol Chem. 1997 Feb 21; 272(8):4663-70. PMID: 9030517.
      View in: PubMed
    39. Rosenthal S, Cheng ZQ. Opposing early and late effects of insulin-like growth factor I on differentiation and the cell cycle regulatory retinoblastoma protein in skeletal myoblasts. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10307-11. PMID: 7479773; PMCID: PMC40785.
      View in: PubMed, PubMed Central
    40. Burch GH, Bedolli MA, McDonough S, Rosenthal S, Bristow J. Embryonic expression of tenascin-X suggests a role in limb, muscle, and heart development. Dev Dyn. 1995 Aug; 203(4):491-504. PMID: 7496040.
      View in: PubMed
    41. Silverman LA, Cheng ZQ, Hsiao D, Rosenthal S. Skeletal muscle cell-derived insulin-like growth factor (IGF) binding proteins inhibit IGF-I-induced myogenesis in rat L6E9 cells. Endocrinology. 1995 Feb; 136(2):720-6. PMID: 7530651.
      View in: PubMed
    42. Rosenthal S, Hsiao D, Silverman LA. An insulin-like growth factor-II (IGF-II) analog with highly selective affinity for IGF-II receptors stimulates differentiation, but not IGF-I receptor down-regulation in muscle cells. Endocrinology. 1994 Jul; 135(1):38-44. PMID: 8013373.
      View in: PubMed
    43. Rosenthal S, Brown EJ. Mechanisms of insulin-like growth factor (IGF)-II-induced IGF-I receptor down-regulation in BC3H-1 muscle cells. J Endocrinol. 1994 Apr; 141(1):69-74. PMID: 8014604.
      View in: PubMed
    44. Uyeki TM, Barry FL, Rosenthal S, Mathias RS. Successful treatment with hydrochlorothiazide and amiloride in an infant with congenital nephrogenic diabetes insipidus. Pediatr Nephrol. 1993 Oct; 7(5):554-6. PMID: 8251321.
      View in: PubMed
    45. Goodman PA, Sbraccia P, Brunetti A, Wong KY, Carter JD, Rosenthal S, Goldfine ID. Growth factor receptor regulation in the Minn-1 leprechaun: defects in both insulin receptor and epidermal growth factor receptor gene expression. Metabolism. 1992 May; 41(5):504-9. PMID: 1316988.
      View in: PubMed
    46. Brown EJ, Hsiao D, Rosenthal S. Induction and peak gene expression of insulin-like growth factor II follow that of myogenin during differentiation of BC3H-1 muscle cells. Biochem Biophys Res Commun. 1992 Mar 31; 183(3):1084-9. PMID: 1314574.
      View in: PubMed
    47. Hartmann KK, Baier TG, Papa V, Kronenwett M, Brown EJ, Goldfine ID, Rosenthal S. A monoclonal antibody to the T-cell receptor increases IGF-I receptor content in normal T-lymphocytes: comparison with phytohemagglutinin. J Cell Biochem. 1992 Jan; 48(1):81-5. PMID: 1316362.
      View in: PubMed
    48. Rosenthal S, Silverman BL, Wehrenberg WB. Exogenous growth hormone inhibits bovine but not murine pituitary growth hormone secretion in vitro: evidence for a direct feedback of growth hormone on the pituitary. Neuroendocrinology. 1991 Jun; 53(6):597-600. PMID: 1876236.
      View in: PubMed
    49. Papa V, Hartmann KK, Rosenthal S, Maddux BA, Siiteri PK, Goldfine ID. Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II. Mol Endocrinol. 1991 May; 5(5):709-17. PMID: 1649393.
      View in: PubMed
    50. Rosenthal S, Brown EJ, Brunetti A, Goldfine ID. Fibroblast growth factor inhibits insulin-like growth factor-II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells. Mol Endocrinol. 1991 May; 5(5):678-84. PMID: 1649391.
      View in: PubMed
    51. Rosenthal S, Brunetti A, Brown EJ, Mamula PW, Goldfine ID. Regulation of insulin-like growth factor (IGF) I receptor expression during muscle cell differentiation. Potential autocrine role of IGF-II. J Clin Invest. 1991 Apr; 87(4):1212-9. PMID: 1849146; PMCID: PMC295138.
      View in: PubMed, PubMed Central
    52. Hartmann KK, Papa V, Brown EJ, Doerries U, Rosenthal S, Goldfine ID. A rapid and simple one step method for isolation of poly(A)+ RNA from cells in monolayer. Endocrinology. 1990 Oct; 127(4):2038-40. PMID: 1698153.
      View in: PubMed
    53. Rosenthal S, Kaplan SL, Grumbach MM. Short term continuous intravenous infusion of growth hormone (GH) inhibits GH-releasing hormone-induced GH secretion: a time-dependent effect. J Clin Endocrinol Metab. 1989 Jun; 68(6):1101-5. PMID: 2498383.
      View in: PubMed
    54. Hulse JA, Rosenthal S, Cuttler L, Kaplan SL, Grumbach MM. The effect of pulsatile administration, continuous infusion, and diurnal variation on the growth hormone (GH) response to GH-releasing hormone in normal men. J Clin Endocrinol Metab. 1986 Oct; 63(4):872-8. PMID: 3091629.
      View in: PubMed
    55. Rosenthal S, Hulse JA, Kaplan SL, Grumbach MM. Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men. J Clin Invest. 1986 Jan; 77(1):176-80. PMID: 3080472; PMCID: PMC423324.
      View in: PubMed, PubMed Central
    56. Gondos B, Egli CA, Rosenthal S, Grumbach MM. Testicular changes in gonadotropin-independent familial male sexual precocity. Familial testotoxicosis. Arch Pathol Lab Med. 1985 Nov; 109(11):990-5. PMID: 3901957.
      View in: PubMed
    57. Egli CA, Rosenthal S, Grumbach MM, Montalvo JM, Gondos B. Pituitary gonadotropin-independent male-limited autosomal dominant sexual precocity in nine generations: familial testotoxicosis. J Pediatr. 1985 Jan; 106(1):33-40. PMID: 3917500.
      View in: PubMed
    58. Schriock EA, Lustig RH, Rosenthal S, Kaplan SL, Grumbach MM. Effect of growth hormone (GH)-releasing hormone (GRH) on plasma GH in relation to magnitude and duration of GH deficiency in 26 children and adults with isolated GH deficiency or multiple pituitary hormone deficiencies: evidence for hypothalamic GRH deficiency. J Clin Endocrinol Metab. 1984 Jun; 58(6):1043-9. PMID: 6427257.
      View in: PubMed
    59. Rosenthal S, Grumbach MM, Kaplan SL. Gonadotropin-independent familial sexual precocity with premature Leydig and germinal cell maturation (familial testotoxicosis): effects of a potent luteinizing hormone-releasing factor agonist and medroxyprogesterone acetate therapy in four cases. J Clin Endocrinol Metab. 1983 Sep; 57(3):571-9. PMID: 6223935.
      View in: PubMed
    60. Rosenthal S, Schriock EA, Kaplan SL, Guillemin R, Grumbach MM. Synthetic human pancreas growth hormone-releasing factor (hpGRF1-44-NH2) stimulates growth hormone secretion in normal men. J Clin Endocrinol Metab. 1983 Sep; 57(3):677-9. PMID: 6409919.
      View in: PubMed
    61. Rosenthal S, Reid IA, Kaplan SL, Grumbach MM. Renin substrate depletion in salt-losing congenital virilizing adrenal hyperplasia: low plasma renin activity despite increased renin concentration. J Pediatr. 1983 Jan; 102(1):80-2. PMID: 6294266.
      View in: PubMed
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