James Rubenstein, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-502-4430
ORCID ORCID Icon0000-0002-9062-2449 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS Lymphoma
    NIH R01CA239462Jul 4, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Targeted Therapies in CNS Lymphomas
    NIH R21CA184694Apr 14, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Recognition and Targeting of CNS Lymphoma by Tumor-Associated Macrophages
    NIH R01CA139083Apr 1, 2009 - Jul 31, 2020
    Role: Principal Investigator
    Molecular Classification and therapy of CNS Lymphomas
    NIH K23CA100291Aug 4, 2004 - Jul 31, 2009
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14. Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. PMID: 35157770.
      View in: PubMed   Mentions:
    2. Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment. Blood. 2021 Nov 5; 138(Supplement 1):448-448. Gao GH, Fraser FE, Merlini MM, Geng GH, Chen CL, Lu LM, Moshfegh MY, Cleveland CJ, Ryu RJ, Sharma SJ, Solomon SD, Akassoglou AK, Lowell LC, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    3. Tumor metabolism and neurocognition in CNS lymphoma. Neuro Oncol. 2021 10 01; 23(10):1668-1679. Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL. PMID: 33625503; PMCID: PMC8485453.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Primary central nervous system lymphoma in older adults and the rationale for maintenance strategies: a narrative review. Ann Lymphoma. 2021 Sep; 5. Tsang M, Rubenstein JL, Pulczynski EJ. PMID: 35106521; PMCID: PMC8802984.
      View in: PubMed   Mentions:
    5. A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA. PMID: 34330834; PMCID: PMC8346823.
      View in: PubMed   Mentions:    Fields:    
    6. Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG). Neuro Oncol. 2021 07 01; 23(7):1056-1071. Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, Andronesi OC, Ferreri AJM, Mrugala MM, Grommes C, Neuwelt EA, Ambady P, Rubenstein JL, Illerhaus G, Nagane M, Batchelor TT, Hu LS. PMID: 33560416; PMCID: PMC8248856.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of CALGB 51101 (Alliance). Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):7506-7506. Batchelor BT, Giri GS, Ruppert RA, Bartlett BN, Hsi HE, Cheson CB, Nayak NL, Leonard LJ, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    8. Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma. Am J Pathol. 2021 03; 191(3):575-583. Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK. PMID: 33608067; PMCID: PMC7919853.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide. Blood. 2020 Nov 5; 136(Supplement 1):21-22. Tsang TM, Cleveland CJ, Cerejo CM, Geng GH, Rubenstein RJ. .
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    10. On point in primary CNS lymphoma. Hematol Oncol. 2020 Dec; 38(5):640-647. Tsang M, Cleveland J, Rubenstein JL. PMID: 32510610; PMCID: PMC8815361.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. Cutaneous T-Cell Lymphoma PDX Drug Screening Platform Identifies Cooperation between Inhibitions of PI3Kα/δ and HDAC. J Invest Dermatol. 2021 02; 141(2):364-373. Wu CH, Yang CY, Wang L, Gao HX, Rakhshandehroo T, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ. PMID: 32603749.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of induction therapy in Alliance 51101. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):8042-8042. Batchelor BT, Giri GS, Ruppert RA, Bartlett BN, Hsi HE, Cheson CB, Nayak NL, Leonard LJ, Rubenstein RJ. .
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    13. THERAPEUTIC VITRECTOMY AS AN ADJUNCT TREATMENT TO SYSTEMIC CHEMOTHERAPY FOR INTRAOCULAR LYMPHOMA. Retin Cases Brief Rep. 2020; 14(2):116-119. Bever GJ, Kim DJ, Afshar AR, Rubenstein JL, Damato BE. PMID: 29210961; PMCID: PMC6089662.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies. Blood. 2019 Nov 13; 134(Supplement_1):1494-1494. Solomon SD, Geng GH, Sobel SR, Subbaraj SL, Tsang TM, Rubenstein RJ. .
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    15. Development of a Pathway-Directed Drug Screen Platform for Cutaneous T Cell Lymphoma Using Patient-Derived Xenograft Models. Blood. 2019 Nov 13; 134(Supplement_1):1578-1578. WU WC, Yang YC, Wang WL, Gao GH, Taha TR, Afghani AS, Pincus PL, Balassanian BR, Rubenstein RJ, Gill GR, Bandyopadhyay BS, McCormick MF, Moasser MM, Ai AW. .
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    16. Maintenance lenalidomide in primary CNS lymphoma. Ann Oncol. 2019 08 01; 30(8):1397-1398. Rubenstein JL, Geng H, Vu K, Mannis G, Formaker P, Hwang J, Munster PN, Damato B. PMID: 31046114; PMCID: PMC8887569.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. An audit of retinal lymphoma treatment at the University of California San Francisco. Eye (Lond). 2020 03; 34(3):515-522. Damato B, Bever GJ, Kim DJ, Afshar AR, Rubenstein JL. PMID: 31358925; PMCID: PMC7042248.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Evolving Treatments for Primary Central Nervous System Lymphoma. Am Soc Clin Oncol Educ Book. 2019 Jan; 39:454-466. Ferreri AJM, Holdhoff M, Nayak L, Rubenstein JL. PMID: 31099614.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma. Neuro Oncol. 2019 02 19; 21(3):296-305. Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT. PMID: 30418592; PMCID: PMC6380418.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    20. Low-dose lenalidomide maintenance after induction therapy in older patients with primary central nervous system lymphoma. Br J Haematol. 2019 07; 186(1):180-183. Vu K, Mannis G, Hwang J, Geng H, Rubenstein JL. PMID: 30714128; PMCID: PMC8776513.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma. Blood. 2018 Nov 29; 132(Supplement 1):2840-2840. Geng GH, Tiret TB, Gao GH, Kadoch KC, Lu LM, Chen CL, Park PI, Melkus MG, Elkhaled EA, Kurhanewicz KJ, Drew DL, Degorce DS, Mayo MM, Dillman DK, Anjum AR, Bloecher BA, Chaumeil CM, Rubenstein RJ. .
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    22. Low-Dose Lenalidomide Maintenance after Induction Therapy in Older Patients with Primary CNS Lymphoma. Blood. 2018 Nov 29; 132(Supplement 1):4230-4230. Vu VK, Rubenstein RJ, Mannis MG, Hwang HJ, Geng GH. .
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    23. RTHP-31. STEREOTACTIC RADIOSURGERY FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi231-vi231. Wu WS, Braunstein BS, Rubenstein RJ, Sneed SP. .
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    24. Can rituximab unlock the innate potential of checkpoint blockade in the CNS? Leuk Lymphoma. 2019 02; 60(2):281-283. Rubenstein JL. PMID: 30188237.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    25. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018 07 10; 2(13):1595-1607. Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B. PMID: 29986852; PMCID: PMC6039666.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    26. Insights from a Case of Vitreoretinal Lymphoma. Ocul Oncol Pathol. 2019 Jan; 5(1):13-19. Damato BE, Bever GJ, Afshar AR, Rubenstein JL. PMID: 30675472; PMCID: PMC6341330.
      View in: PubMed   Mentions: 1  
    27. Biology of CNS lymphoma and the potential of novel agents. Hematology Am Soc Hematol Educ Program. 2017 12 08; 2017(1):556-564. Rubenstein JL. PMID: 29222305; PMCID: PMC6053314.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. EXTH-71. HYPERPOLARIZED [1-13C] PYRUVATE AS A BIOMARKER FOR TREATMENT MONITORING IN LYMPHOMA MURINE MODELS. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi88-vi88. Tiret TB, Autry AA, Park PI, Lu LM, Anjum AR, Drew DL, Degorce DS, Mayo MM, Dillman DK, Rubenstein RJ, Chaumeil CM. .
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    29. CHECKMATE 647: A PHASE 2, OPEN-LABEL STUDY OF NIVOLUMAB IN RELAPSED/REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA OR RELAPSED/REFRACTORY PRIMARY TESTICULAR LYMPHOMA. Hematological Oncology. 2017 Jun 1; 35(S2):420-421. Nayak NL, Iwamoto IF, Ferreri FA, Santoro SA, Singer SS, Batlevi BC, Batchelor BT, Rubenstein RJ, Johnston JP, Ramchandren RR, Soussain SC, Drappatz DJ, Becker BK, Witzens-Harig WM, Illerhaus IG, Herrera HA, Masood MA, Shipp SM. .
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    30. Preliminary analysis of lenalidomide maintenance after methotrexate-temozolomide-rituximab induction in older patients with PCNSL. Hematological Oncology. 2017 Jun 1; 35(S2):343-344. Rubenstein RJ, Hwang HJ, Mannis MG. .
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    31. Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy. Leuk Lymphoma. 2017 11; 58(11):2748-2751. Gupta NK, Wang CC, Mannis GN, Yu JJ, Rubenstein JL. PMID: 28395565; PMCID: PMC6026016.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma. Blood. 2016 Dec 2; 128(22):777-777. Geng GH, Gao GH, Kadoch KC, Lu LM, Chen CL, Anjum AR, Drew DL, Degorce DS, Dillman DK, Mayo MM, Anderson AS, Collins CC, Lowell LC, Rubenstein RJ. .
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    33. The Challenge of Primary Central Nervous System Lymphoma. Hematol Oncol Clin North Am. 2016 Dec; 30(6):1293-1316. Carnevale J, Rubenstein JL. PMID: 27888882; PMCID: PMC5127405.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    34. ATIM-27. PHASE I INVESTIGATION OF LENALIDOMIDE PLUS RITUXIMAB AND OUTCOMES OF LENALIDOMIDE MAINTENANCE IN RECURRENT CNS LYMPHOMA. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi23-vi24. Rubenstein RJ, Fraser FE, Formaker FP, Lee LJ, Chen CN, Kock KM, Cheung CW, Killea KP, Choi CK, Wang WX, Munster MP, Damato DB. .
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    35. Long-term survival in AIDS-related primary central nervous system lymphoma. Neuro Oncol. 2017 01; 19(1):99-108. Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL. PMID: 27576871; PMCID: PMC5193026.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    36. Phase I investigation of lenalidomide plus rituximab and outcomes of lenalidomide maintenance in recurrent CNS lymphoma. Journal of Clinical Oncology. 2016 May 20; 34(15_suppl):7502-7502. Rubenstein RJ, Fraser FE, Formaker FP, Lee LJ, Chen CN, Kock KM, Cheung CW, Wang WX, Munster MP, Damato DB. .
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    37. The role of whole brain radiation in primary CNS lymphoma. Blood. 2016 07 07; 128(1):32-6. Kasenda B, Loeffler J, Illerhaus G, Ferreri AJ, Rubenstein J, Batchelor TT. PMID: 27207798; PMCID: PMC4968379.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    38. Therapy for Secondary CNS Involvement in Malignant Lymphomas: No Standard Yet! J Clin Oncol. 2016 05 20; 34(15):1829-30. Korfel A, Chamberlain M, Neuwelt E, Thiel E, Doolittle N, Schlegel U, Dreyling M, Rubenstein J, Fischer L, Björkholm M, Martus P, Weller M, Glantz M. PMID: 27001566; PMCID: PMC5321044.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Expression of B and T Lymphocyte Attenuator (BTLA) Correlates with CNS Metastasis and Adverse Prognosis in Activated B-Cell Lymphoma and Acute Lymphoblastic Leukemia. Blood. 2015 Dec 3; 126(23):3900-3900. Geng GH, Chen CZ, Anderson AS, Fraser FE, Lu LM, Lingjing LC, Collins CC, Markus MM, Rubenstein RJ. .
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    40. Performance of Apparent Diffusion Coefficient Values and Conventional MRI Features in Differentiating Tumefactive Demyelinating Lesions From Primary Brain Neoplasms. AJR Am J Roentgenol. 2015 Nov; 205(5):1075-85. Mabray MC, Cohen BA, Villanueva-Meyer JE, Valles FE, Barajas RF, Rubenstein JL, Cha S. PMID: 26496556; PMCID: PMC4679155.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    41. Prolonged Complete Response in a Pediatric Patient With Primary Peripheral T-Cell Lymphoma of the Central Nervous System. Pediatr Hematol Oncol. 2015; 32(8):529-34. Shalabi H, Angiolillo A, Vezina G, Rubenstein JL, Pittaluga S, Raffeld M, Marcus L. PMID: 26384083; PMCID: PMC4942274.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. New approaches in primary central nervous system lymphoma. Chin Clin Oncol. 2015 Mar; 4(1):11. Fraser E, Gruenberg K, Rubenstein JL. PMID: 25841718; PMCID: PMC4942281.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    43. 77-year-old woman with a dural-based mass. Marginal zone B-cell lymphoma (MZBCL). Brain Pathol. 2015 Jan; 25(1):111-2. Okimoto RA, Perry A, Rubenstein JL. PMID: 25521182; PMCID: PMC4942276.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. Interim Results of a Phase I Study of Lenalidomide (CC-5013) Plus Intraventricular/Intravenous Rituximab for Recurrent/Refractory CNS and Intraocular Lymphoma. Blood. 2014 Dec 6; 124(21):4470-4470. Rubenstein RJ, Formaker FP, Wang WX, Chen CN, Seider SM, Munster MP, Damato DB. .
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    45. Progress in central nervous system lymphomas. Br J Haematol. 2014 Aug; 166(3):311-25. Wang CC, Carnevale J, Rubenstein JL. PMID: 24837460; PMCID: PMC4107064.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    46. Reply to M.C. Chamberlain. J Clin Oncol. 2014 Mar 10; 32(8):858-9. Rubenstein JL, Cheson BD, Jung SH, Kaplan LD. PMID: 24493718; PMCID: PMC3940542.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. CNS Lymphoma. Rare Lymphomas. 2014 Jan 1; 207-223. Korfel KA, Rubenstein RJ, Ott OG, Hsi HE. .
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    48. 50 Brain Metastases and Neoplastic Meningitis. . 2014 Jan 1; (Cancer 94 10 2002):725-738.e4. Sneed SP, Kased KN, Rubenstein RJ. .
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    49. Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy. Blood. 2013 Nov 15; 122(21):374-374. Gao GH, Anderson AS, Kadoch KC, Maiti MM, Chen CL, Yao YD, Melkus MG, Wang WM, Ren RY, Breider BM, Heise HC, Lowell LC, Collins CC, Rubenstein RJ. .
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    50. High-Dose Methotrexate Is Effective, Safe, and Leads To Durable Responses In Patients With AIDS-Related Primary Central Nervous System Lymphoma Treated During The Era Of Combined Anti-Retroviral Therapy. Blood. 2013 Nov 15; 122(21):1792-1792. Gupta GN, Hwang HJ, Rubenstein RJ. .
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    51. Obesity and Hepatitis B Infection and Risk Of Primary CNS Lymphoma. Blood. 2013 Nov 15; 122(21):4298-4298. Wang WC, Bracci BP, Rubenstein RJ. .
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    52. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41. Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. PMID: 24190981; PMCID: PMC3944388.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    53. How I treat CNS lymphomas. Blood. 2013 Oct 03; 122(14):2318-30. Rubenstein JL, Gupta NK, Mannis GN, Lamarre AK, Treseler P. PMID: 23963042; PMCID: PMC3790503.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    54. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 06; 121(23):4740-8. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. PMID: 23570798; PMCID: PMC3674672.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    55. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol. 2013 Sep 01; 31(25):3061-8. Rubenstein JL, Hsi ED, Johnson JL, Jung SH, Nakashima MO, Grant B, Cheson BD, Kaplan LD. PMID: 23569323; PMCID: PMC3753699.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCTClinical Trials
    56. A systematic approach to the diagnosis of suspected central nervous system lymphoma. JAMA Neurol. 2013 Mar 01; 70(3):311-9. Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA. PMID: 23319132; PMCID: PMC4135394.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    57. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. PMID: 23197589; PMCID: PMC3563362.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    58. BCL6 Expression and Treatment Delay Correlate with Adverse Outcome in Newly Diagnosed Primary CNS Lymphoma: Final Report of CALGB 50202 (Alliance). Blood. 2012 Nov 16; 120(21):301-301. Rubenstein RJ, Hsi HE, Johnson JJ, Jung JS, Grant GB, Cheson CB, Kaplan KL. .
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    59. Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. Clin Cancer Res. 2012 Feb 15; 18(4):1146-55. Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL. PMID: 22228634; PMCID: PMC3288204.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCTClinical Trials
    60. Biology of Primary Central Nervous System Lymphoma. Lymphoma and Leukemia of the Nervous System. 2012 Jan 1; 99-111. Rubenstein RJ. .
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    61. Combined Diffusion and Perfusion MRI As Biomarkers of Prognosis in Immunocompetent Patients with Primary CNS Lymphoma. Blood. 2011 Nov 18; 118(21):2655-2655. Valles VF, Regalado RS, Rubenstein RJ, Cha CS. .
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    62. Multicenter Phase I Trial of Intraventricular Immuno-Chemotherapy in Recurrent CNS Lymphoma. Blood. 2011 Nov 18; 118(21):959-959. Rubenstein RJ, Chen CL, Advani AR, Drappatz DJ, Gerstner GE, Batchelor BT, Krouwer KH, Kadoch KC, Munster MP, Cha CS, Shuman SM, Damon DL. .
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    63. Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,. Blood. 2011 Nov 18; 118(21):3219-3219. Kadoch KC, Wong WV, Chen CL, Bet-Lachin BA, Roy RR, Hyun HW, Behler BC, Lowell LC, Rubenstein RJ. .
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    64. Metabolic Profiling of CNS Lymphoma and Its Microenvironment. Blood. 2011 Nov 18; 118(21):588-588. Bet-Lachin BA, Jiang JF, Chen CL, Keshari KK, Wilson WD, Kurhanewicz KJ, Rubenstein RJ. .
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    65. Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,. Blood. 2011 Nov 18; 118(21):3477-3477. Gao GH, Anderson AS, Chen CL, Kadoch KC, Hann HB, Lowell LC, Collins CC, Rubenstein RJ. .
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    66. Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. Oncologist. 2011; 16(11):1589-99. Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, Cassoux N, Touitou V, Smith JR, Batchelor TT, Pulido JS. PMID: 22045784; PMCID: PMC3233294.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    67. Regression of refractory intraocular large B-cell lymphoma with lenalidomide monotherapy. J Clin Oncol. 2011 Jul 10; 29(20):e595-7. Rubenstein JL, Treseler PA, Stewart PJ. PMID: 21519022; PMCID: PMC3675664.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    68. Intensive Chemotherapy and Immunotherapy, without Brain Irradiation, In Newly Diagnosed Patients with Primary CNS Lymphoma: Results of CALGB 50202. Blood. 2010 Nov 19; 116(21):763-763. Rubenstein RJ, Johnson JJ, Jung JS, Cheson CB, Kaplan KL. .
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    69. Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy. Journal of Clinical Oncology. 2010 May 20; 28(15_suppl):2532-2532. Rubenstein RJ, Kadoch KC, Wong WV, Hyun HW, Lowell LC. .
      View in: Publisher Site   Mentions:
    70. Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma. Blood. 2009 Nov 20; 114(22):3749-3749. Kadoch KC, Wong WV, Rambaldo RT, Hyun HW, Lowell LC, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    71. Biology and treatment of primary central nervous system lymphoma. Neurotherapeutics. 2009 Jul; 6(3):587-97. Algazi AP, Kadoch C, Rubenstein JL. PMID: 19560747; PMCID: PMC4942275.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    72. Reply to H. Zetterberg et al. Journal of Clinical Oncology. 2009 May 1; 27(13):2303-2304. Rubenstein RJ, Chen CL, Kadoch KC, Roy RS, Becker BC, Schulman SH. .
      View in: Publisher Site   Mentions:
    73. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. PMID: 19276270; PMCID: PMC4372389.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    74. Insights into the biology of primary central nervous system lymphoma. Curr Oncol Rep. 2009 Jan; 11(1):73-80. Mrugala MM, Rubenstein JL, Ponzoni M, Batchelor TT. PMID: 19080745; PMCID: PMC4110181.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    75. Differential gene expression in central nervous system lymphoma. Blood. 2009 Jan 01; 113(1):266-7; author reply 267-8. Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA. PMID: 19122120; PMCID: PMC2614638.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    76. Sarcoidosis of the pineal gland: an unusual presentation of neurosarcoidosis. J Neurooncol. 2009 Jan; 91(1):113-6. Yang I, Delpolyi A, Sughrue ME, Rubenstein J, Bollen AW, Parsa AT. PMID: 18759061; PMCID: PMC4134350.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    77. Primary lymphoma of the central nervous system: epidemiology, pathology and current approaches to diagnosis, prognosis and treatment. Leuk Lymphoma. 2008; 49 Suppl 1:43-51. Rubenstein J, Ferreri AJ, Pittaluga S. PMID: 18821432; PMCID: PMC4110179.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    78. Chapter 56 Brain Metastases and Neoplastic Meningitis. Abeloff\u0027s Clinical Oncology. 2008 Jan 1; 827-844. Sneed SP, Kased KN, Huang HK, Rubenstein RJ. .
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    79. Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol. 2008 Jan 01; 26(1):96-105. Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL. PMID: 18056677; PMCID: PMC4134101.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    80. Complement Activation and Resistance within the Cerebrospinal Fluid Following Intraventricular Administration of Anti-CD20 in the Treatment of Recurrent CNS Lymphoma. Blood. 2007 Nov 16; 110(11):3418-3418. Kadoch KC, Shuman SM, Rubenstein RJ. .
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    81. Treatment of Primary CNS Lymphoma with Induction High-Dose Methotrexate, Temozolomide, Rituximab Followed by Consolidation Cytarabine/Etoposide: A Pilot Study with Biomarker Analysis. Blood. 2007 Nov 16; 110(11):1364-1364. Issa IS, Shen SA, Karch KJ, Kadoch KC, Shuman SM, Damon DL, Rubenstein RJ. .
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    82. In Reply. Journal of Clinical Oncology. 2007 Oct 1; 25(28):4509-4511. Rubenstein RJ, Abrey AL, Advani AR, Shuman SM, Tsai TT, O'Brien OJ. .
      View in: Publisher Site   Mentions:
    83. Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol. 2007 Apr 10; 25(11):1350-6. Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M. PMID: 17312328.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCTClinical Trials
    84. Molecular pathogenesis of primary central nervous system lymphoma. Neurosurg Focus. 2006 Nov 15; 21(5):E1. Kadoch C, Treseler P, Rubenstein JL. PMID: 17134111.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    85. Identification of CSF Biomarkers for the Diagnosis of CNS Lymphoma. Blood. 2006 Nov 1; 108(11):2036-2036. Rubenstein RJ, Kadoch KC, Karch KJ, Josephson JA, Issa IS, Becker BC, Schulman SH, Damon DL, Shuman SM, Roy RS. .
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    86. Treatment of primary CNS lymphoma with induction high-dose methotrexate, temozolomide, rituximab followed by consolidation cytarabine/etoposide: A pilot study with biomarker analysis. Journal of Clinical Oncology. 2006 Jun 20; 24(18_suppl):7595-7595. Issa IS, Hwang HJ, Karch KJ, Fridlyand FJ, Prados PM, Batchelor BT, Aldape AK, Haqq HC, Damon DL, Rubenstein RJ. .
      View in: Publisher Site   Mentions:
    87. Gene expression and angiotropism in primary CNS lymphoma. Blood. 2006 May 01; 107(9):3716-23. Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M. PMID: 16418334; PMCID: PMC1895776.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    88. Surgically (laparotomy/laparoscopy) guided placement of high dose rate interstitial irradiation catheters (LG-HDRT): technique and outcome. Gynecol Oncol. 2006 Jan; 100(1):145-8. Orr JW, Dosoretz DD, Mahoney D, Roland PY, Kelly FJ, Blitzer P, Nakfoor B, Katin M, Rubenstein J, Boothby RR. PMID: 16249021.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    89. Pathology and genetics of primary central nervous system and intraocular lymphoma. Hematol Oncol Clin North Am. 2005 Aug; 19(4):705-17, vii. Rubenstein JL, Treseler P, O'Brien JM. PMID: 16083831.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    90. Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group. J Clin Oncol. 2005 Apr 01; 23(10):2233-9. Shenkier TN, Blay JY, O'Neill BP, Poortmans P, Thiel E, Jahnke K, Abrey LE, Neuwelt E, Tsang R, Batchelor T, Harris N, Ferreri AJ, Ponzoni M, O'Brien P, Rubenstein J, Connors JM. PMID: 15800313.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    91. Primary Central Nervous System Lymphoma of T Cell Origin: A Descriptive Analysis of 45 Cases from the International PCNSL Collaborative Group. Blood. 2004 Nov 16; 104(11):1372-1372. Shenkier ST, Blay BJ, O’Neill OB, Poortmans PP, Janke JK, Abrey AL, Neuwelt NE, Tsang TR, Batchelor BT, Harris HN, Ferreri FA, Ponzoni PM, O’Brien OP, Rubenstein RJ, Connors CJ. .
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    92. Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):6593-6593. Rubenstein RJ, Shen SA, Abrey AL, Combs CD, Haqq HC, Damon DL, O'Brien OJ, O'Connor OP, Prados PM, Shuman SM. .
      View in: Publisher Site   Mentions:
    93. Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):6593-6593. Rubenstein RJ, Shen SA, Abrey AL, Combs CD, Haqq HC, Damon DL, O'Brien OJ, O'Connor OP, Prados PM, Shuman SM. .
      View in: Publisher Site   Mentions:
    94. Brain Metastases from Genitourinary Cancer: Germ Cell, Testicular, Prostate and Bladder Cancer. Intracranial Metastases. 2004 Jan 1; 352-361. Theodosopoulos TP, Rubenstein RJ, McDermott MM. .
      View in: Publisher Site   Mentions:
    95. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood. 2003 Jan 15; 101(2):466-8. Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA. PMID: 12393404.
      View in: PubMed   Mentions: 122     Fields:    Translation:Animals
    96. Hemorrhage and VEGF expression in a case of primary CNS lymphoma. J Neurooncol. 2002 May; 58(1):53-6. Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M. PMID: 12160141.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    97. Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science. 2001 Aug 03; 293(5531):872-5. Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL, Rubenstein JL. PMID: 11486090.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    98. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001 Feb; 29(2):353-66. Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL, Rubenstein JL. PMID: 11239428.
      View in: PubMed   Mentions: 321     Fields:    Translation:AnimalsCells
    99. Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons. Neuron. 2000 Dec; 28(3):727-40. Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL, Rubenstein JL. PMID: 11163262.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    100. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia. 2000 Jul-Aug; 2(4):306-14. Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA. PMID: 11005565; PMCID: PMC1550290.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansAnimalsCells
    101. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 2000 Feb; 127(3):469-82. Galceran J, Miyashita-Lin EM, Devaney E, Rubenstein JL, Rubenstein JL, Grosschedl R. PMID: 10631168.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    102. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, Rubenstein JL, German MS. PMID: 9584121.
      View in: PubMed   Mentions: 198     Fields:    Translation:Animals
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