James Rubenstein, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-502-4430
ORCID ORCID Icon0000-0002-9062-2449 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS Lymphoma
    NIH R01CA239462Jul 4, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Targeted Therapies in CNS Lymphomas
    NIH R21CA184694Apr 14, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Recognition and Targeting of CNS Lymphoma by Tumor-Associated Macrophages
    NIH R01CA139083Apr 1, 2009 - Jul 31, 2020
    Role: Principal Investigator
    Molecular Classification and therapy of CNS Lymphomas
    NIH K23CA100291Aug 4, 2004 - Jul 31, 2009
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2021 Aug 03; 118(31). Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA. PMID: 34330834.
      View in: PubMed   Mentions:
    2. Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG). Neuro Oncol. 2021 Jul 01; 23(7):1056-1071. Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, Andronesi OC, Ferreri AJM, Mrugala MM, Grommes C, Neuwelt EA, Ambady P, Rubenstein JL, Illerhaus G, Nagane M, Batchelor TT, Hu LS. PMID: 33560416.
      View in: PubMed   Mentions:    Fields:    
    3. Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of CALGB 51101 (Alliance). Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):7506-7506. Tracy Batchelor, Sharmila Giri, Amy S. Ruppert, Nancy L. Bartlett, Eric D. Hsi, Bruce D. Cheson, Lakshmi Nayak, John Paul Leonard, James L. Rubenstein. .
      View in: Publisher Site   Mentions:
    4. Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma. Am J Pathol. 2021 03; 191(3):575-583. Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK. PMID: 33608067.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Tumor Metabolism and Neurocognition in CNS Lymphoma. Neuro Oncol. 2021 Feb 24. Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL. PMID: 33625503.
      View in: PubMed   Mentions:    Fields:    
    6. Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide. Blood. 2020 Nov 5; 136(Supplement 1):21-22. Mazie Tsang, Joseph Cleveland, Miguel Carlos Cerejo, Huimin Geng, James L. Rubenstein. .
      View in: Publisher Site   Mentions:
    7. On point in primary CNS lymphoma. Hematol Oncol. 2020 Dec; 38(5):640-647. Tsang M, Cleveland J, Rubenstein JL. PMID: 32510610.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Cutaneous T-Cell Lymphoma PDX Drug Screening Platform Identifies Cooperation between Inhibitions of PI3Ka/d and HDAC. J Invest Dermatol. 2021 Feb; 141(2):364-373. Wu CH, Yang CY, Wang L, Gao HX, Rakhshandehroo T, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ. PMID: 32603749.
      View in: PubMed   Mentions: 3     Fields:    
    9. Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of induction therapy in Alliance 51101. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):8042-8042. Tracy Batchelor, Sharmila Giri, Amy S. Ruppert, Nancy L. Bartlett, Eric D. Hsi, Bruce D. Cheson, Lakshmi Nayak, John Paul Leonard, James L. Rubenstein. .
      View in: Publisher Site   Mentions:
    10. THERAPEUTIC VITRECTOMY AS AN ADJUNCT TREATMENT TO SYSTEMIC CHEMOTHERAPY FOR INTRAOCULAR LYMPHOMA. Retin Cases Brief Rep. 2020; 14(2):116-119. Bever GJ, Kim DJ, Afshar AR, Rubenstein JL, Damato BE. PMID: 29210961.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies. Blood. 2019 Nov 13; 134(Supplement_1):1494-1494. David A. Solomon, Huimin Geng, Raymond A. Sobel, Lakshmi Subbaraj, Mazie Tsang, James L. Rubenstein. .
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    12. Development of a Pathway-Directed Drug Screen Platform for Cutaneous T Cell Lymphoma Using Patient-Derived Xenograft Models. Blood. 2019 Nov 13; 134(Supplement_1):1578-1578. CHI-HENG WU, Chen-Yen Yang, Linlin Wang, Hua-Xin Gao, Rakhshandehroo Taha, Shervin Afghani, Laura Pincus, Ronald Balassanian, James Rubenstein, Ryan Gill, Sourav Bandyopadhyay, Frank McCormick, Mark Moasser, Weiyun Z. Ai. .
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    13. Maintenance lenalidomide in primary CNS lymphoma. Ann Oncol. 2019 08 01; 30(8):1397-1398. Rubenstein JL, Geng H, Vu K, Mannis G, Formaker P, Hwang J, Munster PN, Damato B. PMID: 31046114.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. An audit of retinal lymphoma treatment at the University of California San Francisco. Eye (Lond). 2020 03; 34(3):515-522. Damato B, Bever GJ, Kim DJ, Afshar AR, Rubenstein JL. PMID: 31358925.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Evolving Treatments for Primary Central Nervous System Lymphoma. Am Soc Clin Oncol Educ Book. 2019 Jan; 39:454-466. Ferreri AJM, Holdhoff M, Nayak L, Rubenstein JL. PMID: 31099614.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma. Neuro Oncol. 2019 02 19; 21(3):296-305. Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT. PMID: 30418592.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    17. Low-dose lenalidomide maintenance after induction therapy in older patients with primary central nervous system lymphoma. Br J Haematol. 2019 07; 186(1):180-183. Vu K, Mannis G, Hwang J, Geng H, Rubenstein JL. PMID: 30714128.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Low-Dose Lenalidomide Maintenance after Induction Therapy in Older Patients with Primary CNS Lymphoma. Blood. 2018 Nov 29; 132(Supplement 1):4230-4230. Khoan Vu, James Rubenstein, Gabriel N. Mannis, Jimmy Hwang, Huimin Geng. .
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    19. Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma. Blood. 2018 Nov 29; 132(Supplement 1):2840-2840. Huimin Geng, Brice Tiret, Hua-Xin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Ilwoo Park, Gerd Melkus, Adam Elkhaled, John Kurhanewicz, Lisa Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, Rana Anjum, Andrew Bloecher, Myriam Chaumeil, James Rubenstein. .
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    20. RTHP-31. STEREOTACTIC RADIOSURGERY FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi231-vi231. Susan Wu, Steve Braunstein, James Rubenstein, Penny Sneed. .
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    21. Can rituximab unlock the innate potential of checkpoint blockade in the CNS? Leuk Lymphoma. 2019 02; 60(2):281-283. Rubenstein JL. PMID: 30188237.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv. 2018 07 10; 2(13):1595-1607. Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B. PMID: 29986852.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    23. Insights from a Case of Vitreoretinal Lymphoma. Ocul Oncol Pathol. 2019 Jan; 5(1):13-19. Damato BE, Bever GJ, Afshar AR, Rubenstein JL. PMID: 30675472.
      View in: PubMed   Mentions:
    24. Biology of CNS lymphoma and the potential of novel agents. Hematology Am Soc Hematol Educ Program. 2017 12 08; 2017(1):556-564. Rubenstein JL. PMID: 29222305.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. EXTH-71. HYPERPOLARIZED [1-13C] PYRUVATE AS A BIOMARKER FOR TREATMENT MONITORING IN LYMPHOMA MURINE MODELS. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi88-vi88. Brice Tiret, Adam Autry, Ilwoo Park, Ming Lu, Rana Anjum, Liza Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, James Rubenstein, Myriam M Chaumeil. .
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    26. Preliminary analysis of lenalidomide maintenance after methotrexate-temozolomide-rituximab induction in older patients with PCNSL. Hematological Oncology. 2017 Jun 1; 35(S2):343-344. J.L. Rubenstein, J. Hwang, G. Mannis. .
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    27. CHECKMATE 647: A PHASE 2, OPEN-LABEL STUDY OF NIVOLUMAB IN RELAPSED/REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA OR RELAPSED/REFRACTORY PRIMARY TESTICULAR LYMPHOMA. Hematological Oncology. 2017 Jun 1; 35(S2):420-421. L. Nayak, F.M. Iwamoto, A.J. Ferreri, A. Santoro, S. Singer, C. Batlevi, T. Batchelor, J. Rubenstein, P. Johnston, R. Ramchandren, C. Soussain, J. Drappatz, K. Becker, M. Witzens-Harig, G. Illerhaus, A. Herrera, A. Masood, M. Shipp. .
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    28. Regression of methotrexate-resistant AIDS-related primary central nervous system lymphoma with lenalidomide plus combination anti-retroviral therapy. Leuk Lymphoma. 2017 11; 58(11):2748-2751. Gupta NK, Wang CC, Mannis GN, Yu JJ, Rubenstein JL. PMID: 28395565.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma. Blood. 2016 Dec 2; 128(22):777-777. Huimin Geng, Huaxin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Rana Anjum, Lisa Drew, Sebastien Degorce, Keith Dillman, Michele Mayo, Shawn Anderson, Colin Collins, Clifford A. Lowell, James L. Rubenstein. .
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    30. The Challenge of Primary Central Nervous System Lymphoma. Hematol Oncol Clin North Am. 2016 Dec; 30(6):1293-1316. Carnevale J, Rubenstein JL. PMID: 27888882.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    31. ATIM-27. PHASE I INVESTIGATION OF LENALIDOMIDE PLUS RITUXIMAB AND OUTCOMES OF LENALIDOMIDE MAINTENANCE IN RECURRENT CNS LYMPHOMA. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi23-vi24. James Rubenstein, Eleanor Fraser, Paul Formaker, James Chi-Chiang Lee, Nianhang Chen, Mallory Kock, Wesley Cheung, Phoebe Killea, Kee-Hyun Choi, Xiaomin Wang, Pamela Munster, Bertil Damato. .
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    32. Long-term survival in AIDS-related primary central nervous system lymphoma. Neuro Oncol. 2017 01; 19(1):99-108. Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL. PMID: 27576871.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. Phase I investigation of lenalidomide plus rituximab and outcomes of lenalidomide maintenance in recurrent CNS lymphoma. Journal of Clinical Oncology. 2016 May 20; 34(15_suppl):7502-7502. James L. Rubenstein, Eleanor Fraser, Paul Formaker, James Chi-Chiang Lee, Nianhang Chen, Mallory Kock, Wesley Cheung, Xiaomin Wang, Pamela N. Munster, Bertil Damato. .
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    34. The role of whole brain radiation in primary CNS lymphoma. Blood. 2016 07 07; 128(1):32-6. Kasenda B, Loeffler J, Illerhaus G, Ferreri AJ, Rubenstein J, Batchelor TT. PMID: 27207798.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Therapy for Secondary CNS Involvement in Malignant Lymphomas: No Standard Yet! J Clin Oncol. 2016 05 20; 34(15):1829-30. Korfel A, Chamberlain M, Neuwelt E, Thiel E, Doolittle N, Schlegel U, Dreyling M, Rubenstein J, Fischer L, Björkholm M, Martus P, Weller M, Glantz M. PMID: 27001566.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Expression of B and T Lymphocyte Attenuator (BTLA) Correlates with CNS Metastasis and Adverse Prognosis in Activated B-Cell Lymphoma and Acute Lymphoblastic Leukemia. Blood. 2015 Dec 3; 126(23):3900-3900. Huimin Geng, Zhengshan Chen, Shawn Anderson, Eleanor Fraser, Ming Lu, Chen Lingjing, Colin Collins, Muschen Markus, James L. Rubenstein. .
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    37. Performance of Apparent Diffusion Coefficient Values and Conventional MRI Features in Differentiating Tumefactive Demyelinating Lesions From Primary Brain Neoplasms. AJR Am J Roentgenol. 2015 Nov; 205(5):1075-85. Mabray MC, Cohen BA, Villanueva-Meyer JE, Valles FE, Barajas RF, Rubenstein JL, Cha S. PMID: 26496556.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. Prolonged Complete Response in a Pediatric Patient With Primary Peripheral T-Cell Lymphoma of the Central Nervous System. Pediatr Hematol Oncol. 2015; 32(8):529-34. Shalabi H, Angiolillo A, Vezina G, Rubenstein JL, Pittaluga S, Raffeld M, Marcus L. PMID: 26384083.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. New approaches in primary central nervous system lymphoma. Chin Clin Oncol. 2015 Mar; 4(1):11. Fraser E, Gruenberg K, Rubenstein JL. PMID: 25841718.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    40. 77-year-old woman with a dural-based mass. Marginal zone B-cell lymphoma (MZBCL). Brain Pathol. 2015 Jan; 25(1):111-2. Okimoto RA, Perry A, Rubenstein JL. PMID: 25521182.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. Interim Results of a Phase I Study of Lenalidomide (CC-5013) Plus Intraventricular/Intravenous Rituximab for Recurrent/Refractory CNS and Intraocular Lymphoma. Blood. 2014 Dec 6; 124(21):4470-4470. James L. Rubenstein, Paul Formaker, Xiaomin Wang, Nianhang Chen, Michael Seider, Pamela Munster, Bertil Damato. .
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    42. Progress in central nervous system lymphomas. Br J Haematol. 2014 Aug; 166(3):311-25. Wang CC, Carnevale J, Rubenstein JL. PMID: 24837460.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    43. Reply to M.C. Chamberlain. J Clin Oncol. 2014 Mar 10; 32(8):858-9. Rubenstein JL, Cheson BD, Jung SH, Kaplan LD. PMID: 24493718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. 50 Brain Metastases and Neoplastic Meningitis. . 2014 Jan 1; (Cancer 94 10 2002):725-738.e4. Penny K. Sneed, Norbert Kased, James L. Rubenstein. .
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    45. CNS Lymphoma. Rare Lymphomas. 2014 Jan 1; 207-223. Agnieszka Korfel, James Rubenstein, German Ott, Eric D. Hsi. .
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    46. High-Dose Methotrexate Is Effective, Safe, and Leads To Durable Responses In Patients With AIDS-Related Primary Central Nervous System Lymphoma Treated During The Era Of Combined Anti-Retroviral Therapy. Blood. 2013 Nov 15; 122(21):1792-1792. Neel K. Gupta, Jimmy Hwang, James L. Rubenstein. .
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    47. Obesity and Hepatitis B Infection and Risk Of Primary CNS Lymphoma. Blood. 2013 Nov 15; 122(21):4298-4298. Chia-Ching J. Wang, Paige M Bracci, James L. Rubenstein. .
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    48. Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy. Blood. 2013 Nov 15; 122(21):374-374. Hua-Xin Gao, Shawn Anderson, Cigall Kadoch, Mekhala Maiti, Lingjing Chen, Dong-Han Yao, Gerd Melkus, Maria Wang, Yan Ren, Michael Breider, Carla Heise, Clifford A. Lowell, Colin Collins, James L. Rubenstein. .
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    49. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41. Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. PMID: 24190981.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    50. How I treat CNS lymphomas. Blood. 2013 Oct 03; 122(14):2318-30. Rubenstein JL, Gupta NK, Mannis GN, Lamarre AK, Treseler P. PMID: 23963042.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    51. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 06; 121(23):4740-8. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. PMID: 23570798.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    52. Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). J Clin Oncol. 2013 Sep 01; 31(25):3061-8. Rubenstein JL, Hsi ED, Johnson JL, Jung SH, Nakashima MO, Grant B, Cheson BD, Kaplan LD. PMID: 23569323.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCTClinical Trials
    53. A systematic approach to the diagnosis of suspected central nervous system lymphoma. JAMA Neurol. 2013 Mar 01; 70(3):311-9. Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA. PMID: 23319132.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    54. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. PMID: 23197589.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCTClinical Trials
    55. BCL6 Expression and Treatment Delay Correlate with Adverse Outcome in Newly Diagnosed Primary CNS Lymphoma: Final Report of CALGB 50202 (Alliance). Blood. 2012 Nov 16; 120(21):301-301. James L. Rubenstein, Eric D. Hsi, Jeffrey L. Johnson, Sin-Ho Jung, Barbara Grant, Bruce D. Cheson, Lawrence D. Kaplan. .
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    56. Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. Clin Cancer Res. 2012 Feb 15; 18(4):1146-55. Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL. PMID: 22228634.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCTClinical Trials
    57. Biology of Primary Central Nervous System Lymphoma. Lymphoma and Leukemia of the Nervous System. 2012 Jan 1; 99-111. James L. Rubenstein. .
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    58. Combined Diffusion and Perfusion MRI As Biomarkers of Prognosis in Immunocompetent Patients with Primary CNS Lymphoma. Blood. 2011 Nov 18; 118(21):2655-2655. Francisco Valles, Samuel Regalado, James L. Rubenstein, Soonmee Cha. .
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    59. Metabolic Profiling of CNS Lymphoma and Its Microenvironment. Blood. 2011 Nov 18; 118(21):588-588. Anna Bet-Lachin, Frank Jiang, Lingjing Chen, Keyvan Keshari, David Wilson, John Kurhanewicz, James L. Rubenstein. .
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    60. Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,. Blood. 2011 Nov 18; 118(21):3219-3219. Cigall Kadoch, Valerie Wong, Lingjing Chen, Anna Bet-Lachin, Ritu Roy, William Hyun, Caroline Behler, Clifford Lowell, James L. Rubenstein. .
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    61. Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,. Blood. 2011 Nov 18; 118(21):3477-3477. Hua-Xin Gao, Shawn Anderson, Lingjing Chen, Cigall Kadoch, Byron C Hann, Clifford Lowell, Colin Collins, James L. Rubenstein. .
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    62. Multicenter Phase I Trial of Intraventricular Immuno-Chemotherapy in Recurrent CNS Lymphoma. Blood. 2011 Nov 18; 118(21):959-959. James L. Rubenstein, Lingjing Chen, Ranjana Advani, Jan Drappatz, Elizabeth Gerstner, Tracy Batchelor, Hendrikus Krouwer, Cigall Kadoch, Pamela Munster, Soonmee Cha, Marc A Shuman, Lloyd E. Damon. .
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    63. Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. Oncologist. 2011; 16(11):1589-99. Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, Cassoux N, Touitou V, Smith JR, Batchelor TT, Pulido JS. PMID: 22045784.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimals
    64. Regression of refractory intraocular large B-cell lymphoma with lenalidomide monotherapy. J Clin Oncol. 2011 Jul 10; 29(20):e595-7. Rubenstein JL, Treseler PA, Stewart PJ. PMID: 21519022.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    65. Intensive Chemotherapy and Immunotherapy, without Brain Irradiation, In Newly Diagnosed Patients with Primary CNS Lymphoma: Results of CALGB 50202. Blood. 2010 Nov 19; 116(21):763-763. James L. Rubenstein, Jeffrey L. Johnson, Sin-Ho Jung, Bruce D. Cheson, Lawrence D. Kaplan. .
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    66. Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy. Journal of Clinical Oncology. 2010 May 20; 28(15_suppl):2532-2532. J. L. Rubenstein, C. Kadoch, V. S. Wong, W. Hyun, C. Lowell. .
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    67. Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma. Blood. 2009 Nov 20; 114(22):3749-3749. Cigall Kadoch, Valerie D. Wong, Tara Rambaldo, William Hyun, Clifford Lowell, James Rubenstein. .
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    68. Biology and treatment of primary central nervous system lymphoma. Neurotherapeutics. 2009 Jul; 6(3):587-97. Algazi AP, Kadoch C, Rubenstein JL. PMID: 19560747.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    69. Reply to H. Zetterberg et al. Journal of Clinical Oncology. 2009 May 1; 27(13):2303-2304. James L. Rubenstein, Lingjing Chen, Cigall Kadoch, Sushmita Roy, Chris Becker, Howard Schulman. .
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    70. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. PMID: 19276270.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    71. Insights into the biology of primary central nervous system lymphoma. Curr Oncol Rep. 2009 Jan; 11(1):73-80. Mrugala MM, Rubenstein JL, Ponzoni M, Batchelor TT. PMID: 19080745.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    72. Differential gene expression in central nervous system lymphoma. Blood. 2009 Jan 01; 113(1):266-7; author reply 267-8. Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA. PMID: 19122120.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    73. Sarcoidosis of the pineal gland: an unusual presentation of neurosarcoidosis. J Neurooncol. 2009 Jan; 91(1):113-6. Yang I, Delpolyi A, Sughrue ME, Rubenstein J, Bollen AW, Parsa AT. PMID: 18759061.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    74. Chapter 56 Brain Metastases and Neoplastic Meningitis. Abeloff\u0027s Clinical Oncology. 2008 Jan 1; 827-844. Penny K. Sneed, Norbert Kased, Kim Huang, James L. Rubenstein. .
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    75. Primary lymphoma of the central nervous system: epidemiology, pathology and current approaches to diagnosis, prognosis and treatment. Leuk Lymphoma. 2008; 49 Suppl 1:43-51. Rubenstein J, Ferreri AJ, Pittaluga S. PMID: 18821432.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    76. Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol. 2008 Jan 01; 26(1):96-105. Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL. PMID: 18056677.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    77. Complement Activation and Resistance within the Cerebrospinal Fluid Following Intraventricular Administration of Anti-CD20 in the Treatment of Recurrent CNS Lymphoma. Blood. 2007 Nov 16; 110(11):3418-3418. Cigall Kadoch, Marc A. Shuman, James L. Rubenstein. .
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    78. Treatment of Primary CNS Lymphoma with Induction High-Dose Methotrexate, Temozolomide, Rituximab Followed by Consolidation Cytarabine/Etoposide: A Pilot Study with Biomarker Analysis. Blood. 2007 Nov 16; 110(11):1364-1364. Samar Issa, Arthur Shen, Jon Karch, Cigall Kadoch, Marc Shuman, Lloyd Damon, James Rubenstein. .
      View in: Publisher Site   Mentions:
    79. In Reply. Journal of Clinical Oncology. 2007 Oct 1; 25(28):4509-4511. James Rubenstein, Lauren Abrey, Ranjana Advani, Marc Shuman, Tony Tsai, Joan O'Brien. .
      View in: Publisher Site   Mentions:
    80. Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol. 2007 Apr 10; 25(11):1350-6. Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M. PMID: 17312328.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCTClinical Trials
    81. Molecular pathogenesis of primary central nervous system lymphoma. Neurosurg Focus. 2006 Nov 15; 21(5):E1. Kadoch C, Treseler P, Rubenstein JL. PMID: 17134111.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    82. Identification of CSF Biomarkers for the Diagnosis of CNS Lymphoma. Blood. 2006 Nov 1; 108(11):2036-2036. James L. Rubenstein, Cigall Kadoch, Jon Karch, Andrew Josephson, Samar Issa, Chris Becker, Howard Schulman, Lloyd Damon, Marc A. Shuman, Sushmita Roy. .
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    83. Treatment of primary CNS lymphoma with induction high-dose methotrexate, temozolomide, rituximab followed by consolidation cytarabine/etoposide: A pilot study with biomarker analysis. Journal of Clinical Oncology. 2006 Jun 20; 24(18_suppl):7595-7595. S. Issa, J. Hwang, J. Karch, J. Fridlyand, M. Prados, T. Batchelor, K. Aldape, C. Haqq, L. Damon, J. Rubenstein. .
      View in: Publisher Site   Mentions:
    84. Gene expression and angiotropism in primary CNS lymphoma. Blood. 2006 May 01; 107(9):3716-23. Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M. PMID: 16418334.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    85. Surgically (laparotomy/laparoscopy) guided placement of high dose rate interstitial irradiation catheters (LG-HDRT): technique and outcome. Gynecol Oncol. 2006 Jan; 100(1):145-8. Orr JW, Dosoretz DD, Mahoney D, Roland PY, Kelly FJ, Blitzer P, Nakfoor B, Katin M, Rubenstein J, Boothby RR. PMID: 16249021.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    86. Pathology and genetics of primary central nervous system and intraocular lymphoma. Hematol Oncol Clin North Am. 2005 Aug; 19(4):705-17, vii. Rubenstein JL, Treseler P, O'Brien JM. PMID: 16083831.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    87. Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group. J Clin Oncol. 2005 Apr 01; 23(10):2233-9. Shenkier TN, Blay JY, O'Neill BP, Poortmans P, Thiel E, Jahnke K, Abrey LE, Neuwelt E, Tsang R, Batchelor T, Harris N, Ferreri AJ, Ponzoni M, O'Brien P, Rubenstein J, Connors JM. PMID: 15800313.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    88. Primary Central Nervous System Lymphoma of T Cell Origin: A Descriptive Analysis of 45 Cases from the International PCNSL Collaborative Group. Blood. 2004 Nov 16; 104(11):1372-1372. Tamara Shenkier, Jean-Yves Blay, Brian P. O’Neill, Philip Poortmans, Kristoph Janke, Lauren E. Abrey, Edward Neuwelt, Richard Tsang, Tracy Batchelor, Nancy Harris, Andres J. Ferreri, Maurilio Ponzoni, Peter O’Brien, James Rubenstein, Joseph M. Connors. .
      View in: Publisher Site   Mentions:
    89. Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):6593-6593. J. L. Rubenstein, A. Shen, L. Abrey, D. Combs, C. Haqq, L. Damon, J. O'Brien, P. O'Connor, M. Prados, M. Shuman. .
      View in: Publisher Site   Mentions:
    90. Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis. Journal of Clinical Oncology. 2004 Jul 15; 22(14_suppl):6593-6593. J. L. Rubenstein, A. Shen, L. Abrey, D. Combs, C. Haqq, L. Damon, J. O'Brien, P. O'Connor, M. Prados, M. Shuman. .
      View in: Publisher Site   Mentions:
    91. Brain Metastases from Genitourinary Cancer: Germ Cell, Testicular, Prostate and Bladder Cancer. Intracranial Metastases. 2004 Jan 1; 352-361. Philip V. Theodosopoulos, James L. Rubenstein, Michael W. McDermott. .
      View in: Publisher Site   Mentions:
    92. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood. 2003 Jan 15; 101(2):466-8. Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA. PMID: 12393404.
      View in: PubMed   Mentions: 121     Fields:    Translation:Animals
    93. Hemorrhage and VEGF expression in a case of primary CNS lymphoma. J Neurooncol. 2002 May; 58(1):53-6. Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M. PMID: 12160141.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    94. Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science. 2001 Aug 03; 293(5531):872-5. Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL. PMID: 11486090.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    95. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001 Feb; 29(2):353-66. Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL. PMID: 11239428.
      View in: PubMed   Mentions: 295     Fields:    Translation:AnimalsCells
    96. Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons. Neuron. 2000 Dec; 28(3):727-40. Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL. PMID: 11163262.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    97. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia. 2000 Jul-Aug; 2(4):306-14. Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA. PMID: 11005565.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
    98. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 2000 Feb; 127(3):469-82. Galceran J, Miyashita-Lin EM, Devaney E, Rubenstein JL, Grosschedl R. PMID: 10631168.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    99. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. PMID: 9584121.
      View in: PubMed   Mentions: 194     Fields:    Translation:Animals
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