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Yukiko Nakano, DDS, PhD

Title(s)Associate Professor, Orofacial Sciences
SchoolSchool of Dentistry
Address707 Parnassus Avenue, #860
San Francisco CA 94143
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    Collapse Biography 
    Collapse education and training
    Tokyo Medical and Dental University, Tokyo, JapanDDS03/2000Dentistry
    Graduate School of Tokyo Medical and Dental University, Tokyo, JapanPh.D.2005Dental Science
    McGill University, Montreal, CanadaPostdoctral Fellow2009Dental Science

    Collapse Overview 
    Collapse overview
    Dr. Nakano’s research explores the molecular and cellular mechanisms that control the formation and mineralization of bone, dentin, and enamel. Her work includes the regulation of phosphatases in bone mineralization, the differentiation of odontoblasts during dentin development, and how enamel formation is influenced by alternative splicing and splicing-derived microRNAs. By revealing how genetic mutations, alternative splicing, extracellular matrix proteins, signaling molecules, ion channels, microRNAs, and environmental factors affect craniofacial mineralization, her studies identify key mechanisms and potential therapeutic targets for inherited and acquired defects in mineralized tissues.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mutations Causing X-Linked Amelogenesis Imperfecta Alter miRNA Formation from Amelogenin Exon4. J Dent Res. 2023 10; 102(11):1210-1219. Shemirani R, Le MH, Nakano Y. PMID: 37563801; PMCID: PMC10548775.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    2. Effects of Early Life Adversity on Tooth Enamel Formation. Front Dent Med. 2022; 3. Shaffer IC, Nakano Y, Pham A, Short A, Nanci A, Zhang Y, Shemirani R, Den Besten PK. PMID: 37034482; PMCID: PMC10079274.
      View in: PubMed   Mentions: 1  
    3. An miRNA derived from amelogenin exon4 regulates expression of transcription factor Runx2 by directly targeting upstream activators Nfia and Prkch. J Biol Chem. 2022 05; 298(5):101807. Shemirani R, Lin G, Abduweli Uyghurturk D, Le M, Nakano Y. PMID: 35271849; PMCID: PMC9061250.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. WDR72 regulates vesicle trafficking in ameloblasts. Sci Rep. 2022 02 18; 12(1):2820. Katsura K, Nakano Y, Zhang Y, Shemirani R, Li W, Den Besten P. PMID: 35181734; PMCID: PMC8857301.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    5. Fluoride Alters Signaling Pathways Associated with the Initiation of Dentin Mineralization in Enamel Fluorosis Susceptible Mice. Biol Trace Elem Res. 2021 Aug; 199(8):3021-3034. Kao YH, Igarashi N, Abduweli Uyghurturk D, Li Z, Zhang Y, Ohshima H, MacDougall M, Takano Y, Den Besten P, Nakano Y. PMID: 33113116.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation. BMC Biol. 2019 12 13; 17(1):104. Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T. PMID: 31830989; PMCID: PMC6909472.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    7. Fluoride related changes in behavioral outcomes may relate to increased serotonin. Physiol Behav. 2019 07 01; 206:76-83. Lu F, Zhang Y, Trivedi A, Jiang X, Chandra D, Zheng J, Nakano Y, Abduweli Uyghurturk D, Jalai R, Onur SG, Mentes A, DenBesten PK. PMID: 30904570; PMCID: PMC6520156.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Fluoride Alters Klk4 Expression in Maturation Ameloblasts through Androgen and Progesterone Receptor Signaling. Front Physiol. 2017; 8:925. Le MH, Nakano Y, Abduweli Uyghurturk D, Zhu L, Den Besten PK. PMID: 29249975; PMCID: PMC5715335.
      View in: PubMed   Mentions: 4  
    9. A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues. Front Physiol. 2016; 7:258. Nakano Y, Le MH, Abduweli D, Ho SP, Ryazanova LV, Hu Z, Ryazanov AG, Den Besten PK, Zhang Y. PMID: 27458382; PMCID: PMC4934143.
      View in: PubMed   Mentions: 19  
    10. Amelogenin Exon4 Forms a Novel miRNA That Directs Ameloblast and Osteoblast Differentiation. J Dent Res. 2016 Apr; 95(4):423-9. Le MH, Warotayanont R, Stahl J, Den Besten PK, Nakano Y. PMID: 26715056.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Exon4 amelogenin transcripts in enamel biomineralization. J Dent Res. 2015 Jun; 94(6):836-42. Stahl J, Nakano Y, Horst J, Zhu L, Le M, Zhang Y, Liu H, Li W, Den Besten PK. PMID: 25792521; PMCID: PMC4485327.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Fluorosed mouse ameloblasts have increased SATB1 retention and Gαq activity. PLoS One. 2014; 9(8):e103994. Zhang Y, Kim JY, Horst O, Nakano Y, Zhu L, Radlanski RJ, Ho S, Den Besten PK. PMID: 25090413; PMCID: PMC4121220.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. WDR72 models of structure and function: a stage-specific regulator of enamel mineralization. Matrix Biol. 2014 Sep; 38:48-58. Katsura KA, Horst JA, Chandra D, Le TQ, Nakano Y, Zhang Y, Horst OV, Zhu L, Le MH, DenBesten PK. PMID: 25008349; PMCID: PMC4185229.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    14. Leucine rich amelogenin peptide alters ameloblast differentiation in vivo. Matrix Biol. 2013 Oct-Nov; 32(7-8):432-42. Stahl J, Nakano Y, Kim SO, Gibson CW, Le T, DenBesten P. PMID: 23747796; PMCID: PMC3830630.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    15. Comparative temporospatial expression profiling of murine amelotin protein during amelogenesis. Cells Tissues Organs. 2012; 195(6):535-49. Somogyi-Ganss E, Nakayama Y, Iwasaki K, Nakano Y, Stolf D, McKee MD, Ganss B. PMID: 21912076.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    16. Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia. J Dent Res. 2011 Apr; 90(4):470-6. McKee MD, Nakano Y, Masica DL, Gray JJ, Lemire I, Heft R, Whyte MP, Crine P, Millán JL. PMID: 21212313; PMCID: PMC3144124.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    17. Regulation of ATPase activity of transglutaminase 2 by MT1-MMP: implications for mineralization of MC3T3-E1 osteoblast cultures. J Cell Physiol. 2010 Apr; 223(1):260-9. Nakano Y, Forsprecher J, Kaartinen MT. PMID: 20049897.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    18. MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. J Bone Miner Res. 2008 Oct; 23(10):1638-49. Addison WN, Nakano Y, Loisel T, Crine P, McKee MD. PMID: 18597632.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    19. Size distribution and molecular associations of plasma fibronectin and fibronectin crosslinked by transglutaminase 2. Protein J. 2008 Jun; 27(4):223-33. Nelea V, Nakano Y, Kaartinen MT. PMID: 18330684.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    20. ATP-mediated mineralization of MC3T3-E1 osteoblast cultures. Bone. 2007 Oct; 41(4):549-61. Nakano Y, Addison WN, Kaartinen MT. PMID: 17669706.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    21. Expression of bone type 1 PTH receptor in rats with chronic renal failure. Clin Exp Nephrol. 2007 Mar; 11(1):34-40. Kuwahara M, Inoshita S, Nakano Y, Terada Y, Takano Y, Sasaki S. PMID: 17384996.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Expression and localization of plasma transglutaminase factor XIIIA in bone. J Histochem Cytochem. 2007 Jul; 55(7):675-85. Nakano Y, Al-Jallad HF, Mousa A, Kaartinen MT. PMID: 17341477.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Formation of acellular cementum-like layers, with and without extrinsic fiber insertion, along inert bone surfaces of aging c-Src gene knockout mice. Eur J Oral Sci. 2006 Dec; 114(6):524-34. Baba O, Miyata A, Abe T, Shibata S, Nakano Y, Terashima T, Oda T, Kudo A, Takano Y. PMID: 17184236.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    24. The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties. Int Immunol. 2006 Sep; 18(9):1375-84. Zhang J, Kawashima N, Suda H, Nakano Y, Takano Y, Azuma M. PMID: 16849394.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    25. Proteolysis on maturing enamel surface, as shown by gel-coating methods. Eur J Oral Sci. 2006 May; 114 Suppl 1:52-8; discussion 93-5, 379-80. Takano Y, Nakano Y, Yamamoto-Shuda Y, Baba O, Terashima T. PMID: 16674663.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures. Matrix Biol. 2006 Apr; 25(3):135-48. Al-Jallad HF, Nakano Y, Chen JL, McMillan E, Lefebvre C, Kaartinen MT. PMID: 16469487.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    27. Eccentric localization of osteocytes expressing enzymatic activities, protein, and mRNA signals for type 5 tartrate-resistant acid phosphatase (TRAP). J Histochem Cytochem. 2004 Nov; 52(11):1475-82. Nakano Y, Toyosawa S, Takano Y. PMID: 15505342; PMCID: PMC3957824.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    28. Site-specific localization of two distinct phosphatases along the osteoblast plasma membrane: tissue non-specific alkaline phosphatase and plasma membrane calcium ATPase. Bone. 2004 Nov; 35(5):1077-85. Nakano Y, Beertsen W, van den Bos T, Kawamoto T, Oda K, Takano Y. PMID: 15542032.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. The induction of enamel and dentin complexes by subcutaneous implantation of reconstructed human and murine tooth germ elements. Arch Histol Cytol. 2004 Mar; 67(1):65-77. Isogawa N, Terashima T, Nakano Y, Kindaichi J, Takagi Y, Takano Y. PMID: 15125024.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    30. Alkaline and acid phosphatases in bone cells serve as phosphohydrolases at physiological pH in vivo: a histochemical implication. Connect Tissue Res. 2003; 44 Suppl 1:219-22. Nakano Y, Kawamoto T, Oda K, Takano Y. PMID: 12952201.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    31. Possible role of dentin matrix in region-specific deposition of cellular and acellular extrinsic fibre cementum. J Electron Microsc (Tokyo). 2003; 52(6):573-80. Takano Y, Sakai H, Watanabe E, Ideguchi-Ohma N, Jayawardena CK, Arai K, Asawa Y, Nakano Y, Shuda Y, Sakamoto Y, Terashima T. PMID: 14756246.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    32. Phosphatase activities of rat intestinal enterocytes and their relation to diverse luminal pH, with special references to the possible localization of phytase along the brush border membrane. Arch Histol Cytol. 2001 Dec; 64(5):483-92. Nakano Y, Kawamoto T, Takano Y. PMID: 11838708.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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