Pamela Den Besten, DDS

Title(s)Professor, Orofacial Sciences
SchoolSchool of Dentistry
Address513 Parnassus Avenue, HSW, #001
San Francisco CA 94143
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    Collapse Research 
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    Enamel biomineralization; the role of pH cycling
    NIH R01DE027971Mar 7, 2019 - Feb 28, 2023
    Role: Principal Investigator
    WDR72 in Tooth Enamel Formation
    NIH R21DE023411Mar 1, 2014 - Feb 28, 2017
    Role: Principal Investigator
    Effects of Fluoride on Behavior in Genetically Diverse Mouse Models
    NIH R21ES017813Feb 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Genetic Variations Related to Fluorosis Susceptibility
    NIH R21DE018633Feb 19, 2008 - Jan 31, 2011
    Role: Principal Investigator
    Ameloblast Differentiation In Vitro: A Step Closer to Enamel Engineering
    NIH R21DE017910Aug 2, 2007 - Jul 31, 2009
    Role: Principal Investigator
    Enamel Fluorosis: Mechanisms of Action
    NIH R01DE013508Dec 1, 1999 - Aug 31, 2015
    Role: Principal Investigator
    Enamel Fluorosis: Mechanisms of Action
    NIH R56DE013508Dec 1, 1999 - Aug 31, 2011
    Role: Principal Investigator
    NIH P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    Oral and Craniofacial Sciences Health Research Training
    NIH T32DE007306Aug 1, 1996 - Jun 30, 2023
    Role: Principal Investigator
    NIH R03DE011733Apr 1, 1996 - Mar 31, 1999
    Role: Principal Investigator
    NIH R01DE010614Feb 1, 1994 - Jan 31, 1999
    Role: Principal Investigator
    NIH R03DE010546Sep 30, 1992 - Sep 29, 1995
    Role: Principal Investigator
    Characterization and Modification of Dental Hard Tissues
    NIH P01DE009859Aug 1, 1991 - Jun 30, 2008
    Role: Co-Investigator
    NIH R01DE009389Sep 1, 1990 - Aug 31, 1994
    Role: Principal Investigator
    NIH R03DE009642Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    NIH R01DE008706Dec 1, 1988 - Nov 30, 1991
    Role: Principal Investigator
    NIH R29DE007384Sep 1, 1985 - Aug 31, 1990
    Role: Principal Investigator
    NIH R23DE007384Sep 1, 1985 - Aug 31, 1988
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fluoride exposure and blood cell markers of inflammation in children and adolescents in the United States: NHANES, 2013-2016. Environ Health. 2022 Oct 27; 21(1):102. Den Besten P, Wells CR, Abduweli Uyghurturk D. PMID: 36289513; PMCID: PMC9608888.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Culturing and Scaling up Stem Cells of Dental Pulp Origin Using Microcarriers. Polymers (Basel). 2021 Nov 15; 13(22). Földes A, Reider H, Varga A, Nagy KS, Perczel-Kovach K, Kis-Petik K, DenBesten P, Ballagi A, Varga G. PMID: 34833250; PMCID: PMC8622966.
      View in: PubMed   Mentions: 1  
    3. Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel Formation. Front Pharmacol. 2021; 12:682654. Földes A, Sang-Ngoen T, Kádár K, Rácz R, Zsembery Á, DenBesten P, Steward MC, Varga G. PMID: 34149428; PMCID: PMC8206558.
      View in: PubMed   Mentions: 2  
    4. TRPM7-Mediated Calcium Transport in HAT-7 Ameloblasts. Int J Mol Sci. 2021 Apr 13; 22(8). Kádár K, Juhász V, Földes A, Rácz R, Zhang Y, Löchli H, Kató E, Köles L, Steward MC, DenBesten P, Varga G, Zsembery Á. PMID: 33924361; PMCID: PMC8069123.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Maternal and fetal exposures to fluoride during mid-gestation among pregnant women in northern California. Environ Health. 2020 04 06; 19(1):38. Abduweli Uyghurturk D, Goin DE, Martinez-Mier EA, Woodruff TJ, DenBesten PK. PMID: 32248806; PMCID: PMC7132865.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansPHPublic Health
    6. Fluoride related changes in behavioral outcomes may relate to increased serotonin. Physiol Behav. 2019 07 01; 206:76-83. Lu F, Zhang Y, Trivedi A, Jiang X, Chandra D, Zheng J, Nakano Y, Abduweli Uyghurturk D, Jalai R, Onur SG, Mentes A, DenBesten PK. PMID: 30904570; PMCID: PMC6520156.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. The Importance of Connexin 43 in Enamel Development and Mineralization. Front Physiol. 2018; 9:750. Al-Ansari S, Jalali R, Plotkin LI, Bronckers ALJJ, DenBesten P, Zhang Y, Raber-Durlacher JE, de Lange J, Rozema FR. PMID: 30013481; PMCID: PMC6036266.
      View in: PubMed   Mentions: 5  
    8. Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016. J Dent Res. 2018 05; 97(5):483-491. Herzog CR, Berzins DW, DenBesten P, Gregory RL, Hargreaves KM, Messer RLW, Mina M, Mooney MP, Paine ML, Phillips C, Presland RB, Quivey RG, Scannapieco FA, Sheridan JF, Svoboda KKH, Trackman PC, Walker MP, Walker SG, Wang CY, Hu JCC. PMID: 29328868; PMCID: PMC6728576.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. No Change in Bicarbonate Transport but Tight-Junction Formation Is Delayed by Fluoride in a Novel Ameloblast Model. Front Physiol. 2017; 8:940. Rácz R, Földes A, Bori E, Zsembery Á, Harada H, Steward MC, DenBesten P, Bronckers ALJJ, Gerber G, Varga G. PMID: 29375389; PMCID: PMC5770627.
      View in: PubMed   Mentions: 10  
    10. Meeting report: a hard look at the state of enamel research. Int J Oral Sci. 2017 11 22; 9(11):e3. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP. PMID: 29165423; PMCID: PMC5775332.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. The Role of Na:K:2Cl Cotransporter 1 (NKCC1/SLC12A2) in Dental Epithelium during Enamel Formation in Mice. Front Physiol. 2017; 8:924. Jalali R, Lodder JC, Zandieh-Doulabi B, Micha D, Melvin JE, Catalan MA, Mansvelder HD, DenBesten P, Bronckers A. PMID: 29209227; PMCID: PMC5702478.
      View in: PubMed   Mentions: 11  
    12. Corrigendum to " Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors" [Archives of Oral Biology 29 (July (83)) (2017) 214-221]. Arch Oral Biol. 2017 12; 84:177. Jalali R, Guy F, Ghazanfari S, Lyaruu D, van Ruijven L, DenBesten P, Martignon S, Castiblanco G, Bronckers A. PMID: 28939035.
      View in: PubMed   Mentions:    Fields:    
    13. Importance of bicarbonate transport in pH control during amelogenesis - need for functional studies. Oral Dis. 2018 Sep; 24(6):879-890. Varga G, DenBesten P, Rácz R, Zsembery Á. PMID: 28834043; PMCID: PMC5817039.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors. Arch Oral Biol. 2017 Nov; 83:214-221. Jalali R, Guy F, Ghazanfari S, Lyaruu D, van Ruijven L, DenBesten P, Martignon S, Castiblanco G, Bronckers ALJJ. PMID: 28806687.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene. J Biol Chem. 2017 08 18; 292(33):13531-13540. Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y. PMID: 28673966; PMCID: PMC5566513.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Buffering of protons released by mineral formation during amelogenesis in mice. Eur J Oral Sci. 2016 10; 124(5):415-425. Bronckers AL, Lyaruu DM, Jalali R, DenBesten PK. PMID: 27422589.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. The C-terminus of amelogenin enhances osteogenic differentiation of human cementoblast lineage cells. J Periodontal Res. 2017 Apr; 52(2):218-224. Kunimatsu R, Yoshimi Y, Hirose N, Awada T, Miyauchi M, Takata T, Li W, Zhu L, Denbesten PK, Tanimoto K. PMID: 27146486.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Effects of C-Terminal Amelogenin Peptide on Proliferation of Human Cementoblast Lineage Cells. J Periodontol. 2016 Jul; 87(7):820-7. Yoshimi Y, Kunimatsu R, Hirose N, Awada T, Miyauchi M, Takata T, Li W, Zhu L, Denbesten P, Tanne K, Tanimoto K. PMID: 27043257.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Ameloblast Modulation and Transport of Cl⁻, Na⁺, and K⁺ during Amelogenesis. J Dent Res. 2015 Dec; 94(12):1740-7. Bronckers AL, Lyaruu D, Jalali R, Medina JF, Zandieh-Doulabi B, DenBesten PK. PMID: 26403673; PMCID: PMC4681480.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    20. Slc26a3/Dra and Slc26a6 in Murine Ameloblasts. J Dent Res. 2015 Dec; 94(12):1732-9. Jalali R, Zandieh-Doulabi B, DenBesten PK, Seidler U, Riederer B, Wedenoja S, Micha D, Bronckers AL. PMID: 26394631; PMCID: PMC4681479.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    21. Composition of mineralizing incisor enamel in cystic fibrosis transmembrane conductance regulator-deficient mice. Eur J Oral Sci. 2015 Feb; 123(1):9-16. Bronckers AL, Lyaruu DM, Guo J, Bijvelds MJ, Bervoets TJ, Zandieh-Doulabi B, Medina JF, Li Z, Zhang Y, DenBesten PK. PMID: 25557910; PMCID: PMC4414926.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    22. Amelogenins as potential buffers during secretory-stage amelogenesis. J Dent Res. 2015 Mar; 94(3):412-20. Guo J, Lyaruu DM, Takano Y, Gibson CW, DenBesten PK, Bronckers AL. PMID: 25535204; PMCID: PMC4336156.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Distinctive genetic activity pattern of the human dental pulp between deciduous and permanent teeth. PLoS One. 2014; 9(7):e102893. Kim JH, Jeon M, Song JS, Lee JH, Choi BJ, Jung HS, Moon SJ, DenBesten PK, Kim SO. PMID: 25047033; PMCID: PMC4105481.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    24. NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. Cell Tissue Res. 2014 Nov; 358(2):433-42. Jalali R, Guo J, Zandieh-Doulabi B, Bervoets TJ, Paine ML, Boron WF, Parker MD, Bijvelds MJ, Medina JF, DenBesten PK, Bronckers AL. PMID: 25012520; PMCID: PMC5142611.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    25. WDR72 models of structure and function: a stage-specific regulator of enamel mineralization. Matrix Biol. 2014 Sep; 38:48-58. Katsura KA, Horst JA, Chandra D, Le TQ, Nakano Y, Zhang Y, Horst OV, Zhu L, Le MH, DenBesten PK. PMID: 25008349; PMCID: PMC4185229.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    26. Barrier formation: potential molecular mechanism of enamel fluorosis. J Dent Res. 2014 Jan; 93(1):96-102. Lyaruu DM, Medina JF, Sarvide S, Bervoets TJ, Everts V, Denbesten P, Smith CE, Bronckers AL. PMID: 24170372; PMCID: PMC3865793.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    27. Inductive ability of human developing and differentiated dental mesenchyme. Cells Tissues Organs. 2013; 198(2):99-110. Zheng L, Warotayanont R, Stahl J, Kunimatsu R, Klein O, DenBesten PK, Zhang Y. PMID: 24192998.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. Parenteral monofluorophosphate (MFP) is a more potent inducer of enamel fluorotic defects in neonatal hamster molars than sodium fluoride. Odontology. 2014 Jul; 102(2):147-53. Lyaruu DM, Schoonderwoerd M, Tio D, Tse C, Bervoets TJ, DenBesten P, Bronckers AL. PMID: 23794061.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    29. Leucine rich amelogenin peptide alters ameloblast differentiation in vivo. Matrix Biol. 2013 Oct-Nov; 32(7-8):432-42. Stahl J, Nakano Y, Kim SO, Gibson CW, Le T, DenBesten P. PMID: 23747796; PMCID: PMC3830630.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. The similarity between human embryonic stem cell-derived epithelial cells and ameloblast-lineage cells. Int J Oral Sci. 2013 Mar; 5(1):1-6. Zheng LW, Linthicum L, DenBesten PK, Zhang Y. PMID: 23538640; PMCID: PMC3632763.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    31. Clinical efficacy and effects of xylitol wipes on bacterial virulence. Adv Dent Res. 2012 Sep; 24(2):117-22. Zhan L, Featherstone JD, Lo J, Krupansky C, Hoang N, DenBesten P, Huynh T. PMID: 22899693.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Enamel pits in hamster molars, formed by a single high fluoride dose, are associated with a perturbation of transitional stage ameloblasts. Caries Res. 2012; 46(6):575-80. Lyaruu DM, Vermeulen L, Stienen N, Bervoets TJ, Denbesten PK, Bronckers AL. PMID: 22947666; PMCID: PMC3591722.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    33. Effects of xylitol wipes on cariogenic bacteria and caries in young children. J Dent Res. 2012 Jul; 91(7 Suppl):85S-90S. Zhan L, Cheng J, Chang P, Ngo M, Denbesten PK, Hoover CI, Featherstone JD. PMID: 22699675; PMCID: PMC3383105.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsPHPublic Health
    34. Amelogenin exons 8 and 9 encoded peptide enhances leucine rich amelogenin peptide mediated dental pulp repair. Cells Tissues Organs. 2012; 196(2):151-60. Huang Y, Goldberg M, Le T, Qiang R, Warner D, Witkowska HE, Liu H, Zhu L, Denbesten P, Li W. PMID: 22301468; PMCID: PMC3677967.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    35. Murine ameloblasts are immunonegative for Tcirg1, the v-H-ATPase subunit essential for the osteoclast plasma proton pump. Bone. 2012 Apr; 50(4):901-8. Bronckers AL, Lyaruu DM, Bervoets TJ, Medina JF, DenBesten P, Richter J, Everts V. PMID: 22245629; PMCID: PMC3345336.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Developmental expression of solute carrier family 26A member 4 (SLC26A4/pendrin) during amelogenesis in developing rodent teeth. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:185-92. Bronckers AL, Guo J, Zandieh-Doulabi B, Bervoets TJ, Lyaruu DM, Li X, Wangemann P, DenBesten P. PMID: 22243245; PMCID: PMC3496853.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. Fluoride incorporation into apatite crystals delays amelogenin hydrolysis. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:3-7. DenBesten PK, Zhu L, Li W, Tanimoto K, Liu H, Witkowska HE. PMID: 22243219; PMCID: PMC3433805.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    38. Evolutionary story of mammalian-specific amelogenin exons 4, "4b", 8, and 9. J Dent Res. 2012 Jan; 91(1):84-9. Sire JY, Huang Y, Li W, Delgado S, Goldberg M, Denbesten PK. PMID: 21948850; PMCID: PMC6728444.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    39. Chronic fluoride toxicity: dental fluorosis. Monogr Oral Sci. 2011; 22:81-96. DenBesten P, Li W. PMID: 21701193; PMCID: PMC3433161.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    40. Altered self-assembly and apatite binding of amelogenin induced by N-terminal proline mutation. Arch Oral Biol. 2011 Apr; 56(4):331-6. Zhu L, Uskokovic V, Le T, Denbesten P, Huang Y, Habelitz S, Li W. PMID: 21081224; PMCID: PMC3427771.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    41. NBCe1 in mouse and human ameloblasts may be indirectly regulated by fluoride. J Dent Res. 2011 Jun; 90(6):782-7. Zheng L, Zhang Y, He P, Kim J, Schneider R, Bronckers AL, Lyaruu DM, DenBesten PK. PMID: 21364089; PMCID: PMC3144118.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    42. Fate of fluoride-induced subameloblastic cysts in developing hamster molar tooth germs. Arch Oral Biol. 2011 Mar; 56(3):238-43. Lyaruu DM, Alberga JM, Kwee NC, Bervoets TJ, Bronckers AL, DenBesten PK. PMID: 21277565; PMCID: PMC4723282.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    43. Ameloblast differentiation in the human developing tooth: effects of extracellular matrices. Matrix Biol. 2010 Jun; 29(5):411-9. He P, Zhang Y, Kim SO, Radlanski RJ, Butcher K, Schneider RA, DenBesten PK. PMID: 20211728; PMCID: PMC3296366.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    44. Horizontal transmission of mutans streptococci in children. J Dent Res. 2010 Jan; 89(1):51-5. Doméjean S, Zhan L, DenBesten PK, Stamper J, Boyce WT, Featherstone JD. PMID: 19918090; PMCID: PMC3318045.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsPHPublic Health
    45. The cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in maturation stage ameloblasts, odontoblasts and bone cells. Bone. 2010 Apr; 46(4):1188-96. Bronckers A, Kalogeraki L, Jorna HJ, Wilke M, Bervoets TJ, Lyaruu DM, Zandieh-Doulabi B, Denbesten P, de Jonge H. PMID: 20004757; PMCID: PMC2842452.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    46. The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosis. J Dent Res. 2009 Oct; 88(10):877-93. Bronckers AL, Lyaruu DM, DenBesten PK. PMID: 19783795; PMCID: PMC3318083.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    47. Calcium-mediated differentiation of ameloblast lineage cells in vitro. J Exp Zool B Mol Dev Evol. 2009 Jul 15; 312B(5):458-64. Chen J, Zhang Y, Mendoza J, Denbesten P. PMID: 19205028.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    48. Dentin extracellular matrix molecules implanted into exposed pulps generate reparative dentin: a novel strategy in regenerative dentistry. J Dent Res. 2009 May; 88(5):396-9. Goldberg M, Six N, Chaussain C, DenBesten P, Veis A, Poliard A. PMID: 19493881; PMCID: PMC2834224.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    49. Functional roles of prolines at amelogenin C terminal during tooth enamel formation. Cells Tissues Organs. 2009; 189(1-4):203-6. Zhu L, Tanimoto K, Le T, DenBesten PK, Li W. PMID: 18701806; PMCID: PMC2824197.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    50. The effect of fluoride on enamel and dentin formation in the uremic rat incisor. Pediatr Nephrol. 2008 Nov; 23(11):1973-9. Lyaruu DM, Bronckers AL, Santos F, Mathias R, DenBesten P. PMID: 18563453; PMCID: PMC7462915.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    51. Inflammatory and immunological aspects of dental pulp repair. Pharmacol Res. 2008 Aug; 58(2):137-47. Goldberg M, Farges JC, Lacerda-Pinheiro S, Six N, Jegat N, Decup F, Septier D, Carrouel F, Durand S, Chaussain-Miller C, Denbesten P, Veis A, Poliard A. PMID: 18602009; PMCID: PMC2853024.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    52. Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta. J Dent Res. 2008 May; 87(5):451-5. Tanimoto K, Le T, Zhu L, Witkowska HE, Robinson S, Hall S, Hwang P, Denbesten P, Li W. PMID: 18434575; PMCID: PMC3677966.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    53. Comparative properties of recombinant human and bovine matrix metalloproteinase-20. Arch Oral Biol. 2008 Aug; 53(8):785-90. Zhu L, Tanimoto K, Robinsin S, Chen J, Witkowska E, Hall S, Le T, Denbesten PK, Li W. PMID: 18336793; PMCID: PMC2516969.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    54. Effects of fluoride on the interactions between amelogenin and apatite crystals. J Dent Res. 2008 Jan; 87(1):39-44. Tanimoto K, Le T, Zhu L, Chen J, Featherstone JD, Li W, DenBesten P. PMID: 18096891; PMCID: PMC3435094.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    55. Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration. Clin Oral Investig. 2008 Jun; 12(2):109-12. Goldberg M, Lacerda-Pinheiro S, Priam F, Jegat N, Six N, Bonnefoix M, Septier D, Chaussain-Miller C, Veis A, Denbesten P, Poliard A. PMID: 18157557; PMCID: PMC2834229.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. The effect of LRAP on enamel organ epithelial cell differentiation. J Dent Res. 2007 Nov; 86(11):1095-9. Le TQ, Zhang Y, Li W, Denbesten PK. PMID: 17959903.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    57. Dentonin, a MEPE fragment, initiates pulp-healing response to injury. J Dent Res. 2007 Aug; 86(8):780-5. Six N, Septier D, Chaussain-Miller C, Blacher R, DenBesten P, Goldberg M. PMID: 17652210.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    58. JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitro. Matrix Biol. 2007 Oct; 26(8):633-41. Zhang Y, Li W, Chi HS, Chen J, Denbesten PK. PMID: 17611094; PMCID: PMC2194802.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    59. Micromolar fluoride alters ameloblast lineage cells in vitro. J Dent Res. 2007 Apr; 86(4):336-40. Yan Q, Zhang Y, Li W, Denbesten PK. PMID: 17384028.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    60. Elevated TGF-beta2 signaling in dentin results in sex related enamel defects. Arch Oral Biol. 2007 Sep; 52(9):814-21. Saeki K, Hilton JF, Alliston T, Habelitz S, Marshall SJ, Marshall GW, Denbesten P. PMID: 17391645; PMCID: PMC2043093.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    61. Comparative calcium binding of leucine-rich amelogenin peptide and full-length amelogenin. Eur J Oral Sci. 2006 May; 114 Suppl 1:320-6; discussion 327-9, 382. Le TQ, Gochin M, Featherstone JD, Li W, DenBesten PK. PMID: 16674706.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    62. Growth of ameloblast-lineage cells in a three-dimensional Matrigel environment. Eur J Oral Sci. 2006 May; 114 Suppl 1:159-63; discussion 164-5, 380-1. Li W, Machule D, Gao C, DenBesten PK. PMID: 16674679.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    63. Self-assembly and effect on crystal growth of the leucine-rich amelogenin peptide. Eur J Oral Sci. 2006 May; 114 Suppl 1:315-9; discussion 327-9, 382. Habelitz S, DenBesten PK, Marshall SJ, Marshall GW, Li W. PMID: 16674705.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    64. Differentiation of human ameloblast-lineage cells in vitro. Eur J Oral Sci. 2006 May; 114 Suppl 1:154-8; discussion 164-5, 380-1. Yan Q, Zhang Y, Li W, DenBesten PK. PMID: 16674678.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    65. Fluoride down-regulates the expression of matrix metalloproteinase-20 in human fetal tooth ameloblast-lineage cells in vitro. Eur J Oral Sci. 2006 May; 114 Suppl 1:105-10; discussion 127-9, 380. Zhang Y, Yan Q, Li W, DenBesten PK. PMID: 16674670.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    66. The impact of bioactive molecules to stimulate tooth repair and regeneration as part of restorative dentistry. Dent Clin North Am. 2006 Apr; 50(2):277-98, x. Goldberg M, Lacerda-Pinheiro S, Jegat N, Six N, Septier D, Priam F, Bonnefoix M, Tompkins K, Chardin H, Denbesten P, Veis A, Poliard A. PMID: 16530063.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    67. On-column activation of bovine recombinant metalloproteinase 20. Anal Biochem. 2006 Sep 15; 356(2):291-3. Wang S, Zhu J, Zhang Y, Li L, DenBesten P, Li W. PMID: 16890905.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    68. Amelogenin control over apatite crystal growth is affected by the pH and degree of ionic saturation. Orthod Craniofac Res. 2005 Nov; 8(4):232-8. Habelitz S, Denbesten PK, Marshall SJ, Marshall GW, Li W. PMID: 16238603.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    69. Mouse amelogenin exons 8 and 9: sequence analysis and protein distribution. J Dent Res. 2005 Jul; 84(7):613-7. Papagerakis P, Ibarra JM, Inozentseva N, DenBesten P, MacDougall M. PMID: 15972588.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    70. MEPE is downregulated as dental pulp stem cells differentiate. Arch Oral Biol. 2005 Nov; 50(11):923-8. Liu H, Li W, Shi S, Habelitz S, Gao C, Denbesten P. PMID: 16183369.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    71. Characterization of human primary enamel organ epithelial cells in vitro. Arch Oral Biol. 2005 Aug; 50(8):689-94. DenBesten PK, Machule D, Zhang Y, Yan Q, Li W. PMID: 15958200.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    72. Effects of sodium fluoride on the actin cytoskeleton of murine ameloblasts. Arch Oral Biol. 2005 Aug; 50(8):681-8. Li Y, Decker S, Yuan ZA, Denbesten PK, Aragon MA, Jordan-Sciutto K, Abrams WR, Huh J, McDonald C, Chen E, MacDougall M, Gibson CW. PMID: 15958199.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    73. Amelogenin-guided crystal growth on fluoroapatite glass-ceramics. J Dent Res. 2004 Sep; 83(9):698-702. Habelitz S, Kullar A, Marshall SJ, DenBesten PK, Balooch M, Marshall GW, Li W. PMID: 15329375.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    74. Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation. J Dent Res. 2004 Jun; 83(6):496-9. Liu H, Li W, Gao C, Kumagai Y, Blacher RW, DenBesten PK. PMID: 15153459.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    75. X-linked amelogenesis imperfecta may result from decreased formation of tyrosine rich amelogenin peptide (TRAP). Arch Oral Biol. 2003 Mar; 48(3):177-83. Li W, Gao C, Yan Y, DenBesten P. PMID: 12648554.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    76. Early childhood caries: an overview with reference to our experience in California. J Calif Dent Assoc. 2003 Feb; 31(2):139-43. DenBesten P, Berkowitz R. PMID: 12636318.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    77. Effects of fluoride on rat dental enamel matrix proteinases. Arch Oral Biol. 2002 Nov; 47(11):763-70. DenBesten PK, Yan Y, Featherstone JD, Hilton JF, Smith CE, Li W. PMID: 12446183.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    78. Expression of alternatively spliced RNA transcripts of amelogenin gene exons 8 and 9 and its end products in the rat incisor. J Histochem Cytochem. 2002 Sep; 50(9):1229-36. Baba O, Takahashi N, Terashima T, Li W, DenBesten PK, Takano Y. PMID: 12185201.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    79. Stem cell properties of human dental pulp stem cells. J Dent Res. 2002 Aug; 81(8):531-5. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, DenBesten P, Robey PG, Shi S. PMID: 12147742.
      View in: PubMed   Mentions: 608     Fields:    Translation:HumansAnimalsCells
    80. Identification of the calcium-sensing receptor in the developing tooth organ. J Bone Miner Res. 2001 Dec; 16(12):2238-44. Mathias RS, Mathews CH, Machule C, Gao D, Li W, Denbesten PK. PMID: 11760837.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    81. The effect of TGF-beta 2 on dentin apposition and hardness in transgenic mice. Adv Dent Res. 2001 Aug; 15:39-41. DenBesten PK, Machule D, Gallagher R, Marshall GW, Mathews C, Filvaroff E. PMID: 12640737.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    82. Reduced hydrolysis of amelogenin may result in X-linked amelogenesis imperfecta. Matrix Biol. 2001 Jan; 19(8):755-60. Li W, Gibson CW, Abrams WR, Andrews DW, DenBesten PK. PMID: 11223334.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    83. Increased fluoride content in the femur growth plate and cortical bone of uremic rats. Pediatr Nephrol. 2000 Sep; 14(10-11):935-9. Mathias RS, Amin U, Mathews CH, Denbesten P. PMID: 10975302.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    84. Is teething associated with diarrhea? West J Med. 2000 Aug; 173(2):137. DenBesten P. PMID: 10924444; PMCID: PMC1071026.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    85. Activation of recombinant bovine matrix metalloproteinase-20 and its hydrolysis of two amelogenin oligopeptides. Eur J Oral Sci. 1999 Oct; 107(5):352-9. Li W, Machule D, Gao C, DenBesten PK. PMID: 10515200.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    86. Development and characterization of an SV40 immortalized porcine ameloblast-like cell line. Eur J Oral Sci. 1999 Aug; 107(4):276-81. DenBesten PK, Gao C, Li W, Mathews CH, Gruenert DC. PMID: 10467943.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    87. Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements. Community Dent Oral Epidemiol. 1999 Feb; 27(1):41-7. DenBesten PK. PMID: 10086925.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    88. Canadian Consensus Conference on the appropriate use of fluoride supplements for the prevention of dental caries in children. J Can Dent Assoc. 1998 Oct; 64(9):636-9. Limeback H, Ismail A, Banting D, DenBesten P, Featherstone J, Riordan PJ. PMID: 9812431.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    89. Identification of two additional exons at the 3' end of the amelogenin gene. Arch Oral Biol. 1998 Jun; 43(6):497-504. Li W, Mathews C, Gao C, DenBesten PK. PMID: 9717587.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    90. Fluoride levels in whole saliva of preschool children after brushing with 0.25 g (pea-sized) as compared to 1.0 g (full-brush) of a fluoride dentifrice. Pediatr Dent. 1996 Jul-Aug; 18(4):277-80. DenBesten P, Ko HS. PMID: 8857654.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    91. Alternative splicing of amelogenin mRNA from rat incisor ameloblasts. J Dent Res. 1995 Dec; 74(12):1880-5. Li R, Li W, DenBesten PK. PMID: 8600184.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    92. Purification of nonamelogenin proteins from bovine secretory enamel. Calcif Tissue Int. 1995 Nov; 57(5):379-84. Punzi JS, DenBesten PK. PMID: 8564801.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    93. Neurotoxicity of sodium fluoride in rats. Neurotoxicol Teratol. 1995 Mar-Apr; 17(2):169-77. Mullenix PJ, Denbesten PK, Schunior A, Kernan WJ. PMID: 7760776.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    94. Effects of chronic fluoride exposure on morphometric parameters defining the stages of amelogenesis and ameloblast modulation in rat incisors. Anat Rec. 1993 Oct; 237(2):243-58. Smith CE, Nanci A, Denbesten PK. PMID: 8238976.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    95. Expression of bone protein mRNA at physiological fluoride concentrations in rat osteoblast culture. Bone Miner. 1993 Sep; 22(3):187-96. Li R, DenBesten PK. PMID: 8268752.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    96. Characterization of amelogenin mRNA from secretory- and maturation-stage rat incisor enamel. Arch Oral Biol. 1992 Dec; 37(12):1097-100. DenBesten PK, Li RS. PMID: 1471959.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    97. Biological mechanisms of fluorosis and level and timing of systemic exposure to fluoride with respect to fluorosis. J Dent Res. 1992 May; 71(5):1238-43. DenBesten PK, Thariani H. PMID: 1607440.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    98. Fluoride binding by matrix proteins in rat mineralizing tissue. Arch Oral Biol. 1992; 37(6):459-62. DenBesten PK, Heffernan LM, Featherstone JD, Shields CP. PMID: 1637261.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    99. The presence and possible functions of the matrix metalloproteinase collagenase activator protein in developing enamel matrix. Biochem J. 1989 Dec 15; 264(3):917-20. DenBesten PK, Heffernan LM, Treadwell BV, Awbrey BJ. PMID: 2619718; PMCID: PMC1133672.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    100. Enamel proteases in secretory and maturation enamel of rats ingesting 0 and 100 PPM fluoride in drinking water. Adv Dent Res. 1989 Sep; 3(2):199-202. DenBesten PK, Heffernan LM. PMID: 2701159.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    101. Separation by polyacrylamide gel electrophoresis of multiple proteases in rat and bovine enamel. Arch Oral Biol. 1989; 34(6):399-404. DenBesten PK, Heffernan LM. PMID: 2688613.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    102. Studies on the changes in developing enamel caused by ingestion of high levels of fluoride in the rat. Adv Dent Res. 1987 Dec; 1(2):176-80. DenBesten PK, Crenshaw MA. PMID: 3504167.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    103. Changes in the fluoride-induced modulation of maturation stage ameloblasts of rats. J Dent Res. 1985 Dec; 64(12):1365-70. Denbesten PK, Crenshaw MA, Wilson MH. PMID: 2416791.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    104. Oral self-mutilation in a child with congenital toxoplasmosis: a clinical report. Pediatr Dent. 1984 Jun; 6(2):98-101. DenBesten PK, McIver FT. PMID: 6592553.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    105. The effects of chronic high fluoride levels on forming enamel in the rat. Arch Oral Biol. 1984; 29(9):675-9. DenBesten PK, Crenshaw MA. PMID: 6594099.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
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