Stefan Habelitz, PhD

Title(s)Professor, Preventive & Restor Dent Sci
SchoolSchool of Dentistry
Address707 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies2001School of Dentistry
    Friedrich Schiller University - Jena GermanyPhD1998Chemistry
    Friedrich-Alexander University, Erlangen-NurnbergMaster and Bachelor of Science1994Materials Engineering
    Collapse Awards and Honors
    NIH/NIDCR2016  - 2021R01-DE25709 Amyloids in Enamel Development
    NIH/NIDCR2012  - 2017RO1-DE16849 Dentin Structure, Demineralization and Remineralization
    NIH/NIDCR2013  - 2015R21-DE023422 A New Concept of Amelogenin-Guided Mineralization in Enamel
    NIH/NIDCR2010  - 2015RO1 DE 015821 Amelogenin degradation by MMP-20 in enamel (PI Wu Li)
    NIH/NIDCR2012  - 2014R21DE022634 Mimicking the Dentin-Pulp Complex In-Vitro

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Remineralization carious lesions in dentin using the PILP-approach
    NIH/NIDCR R21DE028421Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Amyloids in Enamel Development
    NIH/NIDCR R01DE025709Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    A New Concept of Amelogenin-guided Mineralization in Enamel
    NIH/NIDCR R21DE023422Sep 4, 2013 - May 31, 2015
    Role: Principal Investigator
    Mimicking the Dentin-Pulp Complex In-Vitro
    NIH/NIDCR R21DE022634Apr 1, 2012 - Mar 31, 2014
    Role: Principal Investigator
    Recombinant Amelogenin Matrices for Apatite Nanofibers
    NIH/NIDCR R01DE017529Jul 6, 2007 - May 31, 2010
    Role: Principal Investigator
    Dentin Structure, Demineralization and Remineralization
    NIH/NIDCR R01DE016849Jul 1, 2005 - Jun 30, 2017
    Role: Co-Principal Investigator
    Biomimetic Synthesis of an Enamel-Like Material
    NIH/NIDCR R21DE015416Aug 4, 2003 - May 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Protein nanoribbons template enamel mineralization. Proc Natl Acad Sci U S A. 2020 Jul 31. Bai Y, Yu Z, Ackerman L, Zhang Y, Bonde J, Li W, Cheng Y, Habelitz S. PMID: 32737162.
      View in: PubMed   Mentions:    Fields:    
    2. Enhanced silver diamine fluoride therapy using the PILP method -A nanoindentation study. Dent Mater J. 2020 Jul 03. Nurrohman H, Habelitz S, Saeki K, Sadr A, Gower LB, Pazdernik V, Tagami J, Marshall SJ, Marshall GW. PMID: 32624525.
      View in: PubMed   Mentions:    Fields:    
    3. Shear Bond Strength of Glass Ionomer Cement to Silver Diamine Fluoride-Treated Artificial Dentinal Caries. Pediatr Dent. 2020 May 15; 42(3):221-225. Ng E, Saini S, Schulze KA, Horst J, Le T, Habelitz S. PMID: 32522327.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation. BMC Biol. 2019 12 13; 17(1):104. Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T. PMID: 31830989.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Remineralization of demineralized dentin using a dual analog system. Orthod Craniofac Res. 2019 May; 22 Suppl 1:76-81. Saxena N, Habelitz S, Marshall GW, Gower LB. PMID: 31074152.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Integrating the PILP-mineralization process into a restorative dental treatment. Dent Mater. 2019 01; 35(1):53-63. Bacino M, Girn V, Nurrohman H, Saeki K, Marshall SJ, Gower L, Saeed E, Stewart R, Le T, Marshall GW, Habelitz S. PMID: 30545611.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Progression of Self-Assembly of Amelogenin Protein Supramolecular Structures in Simulated Enamel Fluid. Biomacromolecules. 2018 10 08; 19(10):3917-3924. Engelberth SA, Bacino MS, Sandhu S, Li W, Bonde J, Habelitz S. PMID: 30114917.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Influence of fluoride on the mineralization of collagen via the polymer-induced liquid-precursor (PILP) process. Dent Mater. 2018 09; 34(9):1378-1390. Saxena N, Cremer MA, Dolling ES, Nurrohman H, Habelitz S, Marshall GW, Gower LB. PMID: 29935767.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. The role of protease inhibitors on the remineralization of demineralized dentin using the PILP method. PLoS One. 2017; 12(11):e0188277. Nurrohman H, Carneiro KMM, Hellgeth J, Saeki K, Marshall SJ, Marshall GW, Habelitz S. PMID: 29182665.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE. Physiol Rev. 2017 07 01; 97(3):939-993. Lacruz RS, Habelitz S, Wright JT, Paine ML. PMID: 28468833.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    11. Recovery after PILP remineralization of dentin lesions created with two cariogenic acids. Arch Oral Biol. 2017 Oct; 82:194-202. Saeki K, Chien YC, Nonomura G, Chin AF, Habelitz S, Gower LB, Marshall SJ, Marshall GW. PMID: 28647649.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Amyloid-like ribbons of amelogenins in enamel mineralization. Sci Rep. 2016 Mar 24; 6:23105. Carneiro KM, Zhai H, Zhu L, Horst JA, Sitlin M, Nguyen M, Wagner M, Simpliciano C, Milder M, Chen CL, Ashby P, Bonde J, Li W, Habelitz S. PMID: 27009419.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    13. Repair of dentin defects from DSPP knockout mice by PILP mineralization. J. Mater. Res. 2016; 31(3):321-327 . Nurrohman, Hamid; Saeki, Kunkio; Carneiro, Karina M. M.; Chien Y.C., Djomehri, Sabra; Ho, Sunita P.; Qin, Chunlin; Marshall, Sally J.; Marshall, Grayson W. and Habelitz, Stefan.
    14. Repair of dentin defects from DSPP knockout mice by PILP mineralization. J Mater Res. 2016 Feb 15; 31(3):321-327. Nurrohman H, Saeki K, Carneiro K, Chien YC, Djomehri S, Ho SP, Qin C, Marshall SJ, Gower LB, Marshall GW, Habelitz S. PMID: 27239097.
      View in: PubMed   Mentions:
    15. Distinct decalcification process of dentin by different cariogenic organic acids: Kinetics, ultrastructure and mechanical properties. Arch Oral Biol. 2016 Mar; 63:93-105. Chien YC, Burwell AK, Saeki K, Fernandez-Martinez A, Pugach MK, Nonomura G, Habelitz S, Ho SP, Rapozo-Hilo M, Featherstone JD, Marshall SJ, Marshall GW. PMID: 26745819.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    16. Materials engineering by ameloblasts. J Dent Res. 2015 Jun; 94(6):759-67. Habelitz S. PMID: 25800708.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Matching 4.7-Å XRD spacing in amelogenin nanoribbons and enamel matrix. J Dent Res. 2014 Sep; 93(9):918-22. Sanii B, Martinez-Avila O, Simpliciano C, Zuckermann RN, Habelitz S. PMID: 25048248.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Piezoelectric properties of aligned collagen membranes. J Biomed Mater Res B Appl Biomater. 2014 Feb; 102(2):284-92. Denning D, Paukshto MV, Habelitz S, Rodriguez BJ. PMID: 24030958.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    19. The proteolytic processing of amelogenin by enamel matrix metalloproteinase (MMP-20) is controlled by mineral ions. Biochim Biophys Acta. 2013 Mar; 1830(3):2600-7. Khan F, Liu H, Reyes A, Witkowska HE, Martinez-Avila O, Zhu L, Li W, Habelitz S. PMID: 23201201.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils. Biomacromolecules. 2012 Nov 12; 13(11):3494-502. Martinez-Avila O, Wu S, Kim SJ, Cheng Y, Khan F, Samudrala R, Sali A, Horst JA, Habelitz S. PMID: 22974364.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    21. Visualizing molecular polar order in tissues via electromechanical coupling. J Struct Biol. 2012 Dec; 180(3):409-19. Denning D, Alilat S, Habelitz S, Fertala A, Rodriguez BJ. PMID: 22985991.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. Functional remineralization of dentin lesions using polymer-induced liquid-precursor process. PLoS One. 2012; 7(6):e38852. Burwell AK, Thula-Mata T, Gower LB, Habelitz S, Habeliz S, Kurylo M, Ho SP, Chien YC, Cheng J, Cheng NF, Gansky SA, Marshall SJ, Marshall GW. PMID: 22719965.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    23. Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels. Acta Biomater. 2012 Aug; 8(8):3073-9. Denning D, Abu-Rub MT, Zeugolis DI, Habelitz S, Pandit A, Fertala A, Rodriguez BJ. PMID: 22522132.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    24. Biophysical characterization of synthetic amelogenin C-terminal peptides. Eur J Oral Sci. 2012 Apr; 120(2):113-22. Khan F, Li W, Habelitz S. PMID: 22409217.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Self-assembly of amelogenin proteins at the water-oil interface. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:75-82. Martinez-Avila OM, Wu S, Cheng Y, Lee R, Khan F, Habelitz S. PMID: 22243231.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    26. Hydrolysis of amelogenin by matrix metalloprotease-20 accelerates mineralization in vitro. Arch Oral Biol. 2011 Dec; 56(12):1548-59. Uskokovic V, Khan F, Liu H, Witkowska HE, Zhu L, Li W, Habelitz S. PMID: 21774914.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. Biomimetic Precipitation of Uniaxially Grown Calcium Phosphate Crystals from Full-Length Human Amelogenin Sols. J Bionic Eng. 2011 Jun 10; 8(2):114-121. Uskokovic V, Li W, Habelitz S. PMID: 22140380.
      View in: PubMed   Mentions:
    28. Altered self-assembly and apatite binding of amelogenin induced by N-terminal proline mutation. Arch Oral Biol. 2011 Apr; 56(4):331-6. Zhu L, Uskokovic V, Le T, Denbesten P, Huang Y, Habelitz S, Li W. PMID: 21081224.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. Mechanical recovery of dentin following remineralization in vitro--an indentation study. J Biomech. 2011 Jan 04; 44(1):176-81. Bertassoni LE, Habelitz S, Marshall SJ, Marshall GW. PMID: 20926080.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    30. Dynamic light scattering and zeta potential of colloidal mixtures of amelogenin and hydroxyapatite in calcium and phosphate rich ionic milieus. Arch Oral Biol. 2011 Jun; 56(6):521-32. Uskokovic V, Odsinada R, Djordjevic S, Habelitz S. PMID: 21146151.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. Amelogenin as a Promoter of Nucleation and Crystal Growth of Apatite. J Cryst Growth. 2011 Feb 01; 316(1):106-117. Uskokovic V, Li W, Habelitz S. PMID: 30828107.
      View in: PubMed   Mentions:
    32. Self-aligning amelogenin nanoribbons in oil-water system. J Struct Biol. 2011 Apr; 174(1):203-12. He X, Wu S, Martinez-Avila O, Cheng Y, Habelitz S. PMID: 21134461.
      View in: PubMed   Mentions: 13     Fields:    
    33. Evaluation of surface structural and mechanical changes following remineralization of dentin. Scanning. 2010 Sep-Oct; 32(5):312-9. Bertassoni LE, Habelitz S, Pugach M, Soares PC, Marshall SJ, Marshall GW. PMID: 20853406.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    34. Crack arrest within teeth at the dentinoenamel junction caused by elastic modulus mismatch. Biomaterials. 2010 May; 31(14):4238-47. Bechtle S, Fett T, Rizzi G, Habelitz S, Klocke A, Schneider GA. PMID: 20167362.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    35. Mixed-mode stress intensity factors for kink cracks with finite kink length loaded in tension and bending: application to dentin and enamel. J Mech Behav Biomed Mater. 2010 May; 3(4):303-12. Bechtle S, Fett T, Rizzi G, Habelitz S, Schneider GA. PMID: 20346898.
      View in: PubMed   Mentions: 5     Fields:    
    36. Zeta-potential and particle size analysis of human amelogenins. J Dent Res. 2010 Feb; 89(2):149-53. Uskokovic V, Castiglione Z, Cubas P, Zhu L, Li W, Habelitz S. PMID: 20040742.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    37. The fracture behaviour of dental enamel. Biomaterials. 2010 Jan; 31(2):375-84. Bechtle S, Habelitz S, Klocke A, Fett T, Schneider GA. PMID: 19793611.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    38. Intermittent contact mode piezoresponse force microscopy in a liquid environment. Nanotechnology. 2009 May 13; 20(19):195701. Rodriguez BJ, Jesse S, Habelitz S, Proksch R, Kalinin SV. PMID: 19420645.
      View in: PubMed   Mentions: 1     Fields:    
    39. Biomechanical perspective on the remineralization of dentin. Caries Res. 2009; 43(1):70-7. Bertassoni LE, Habelitz S, Kinney JH, Marshall SJ, Marshall GW. PMID: 19208991.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    40. Enzymatic Processing of Amelogenin during Continuous Crystallization of Apatite. J Mater Res. 2008 Dec; 23(12):3184-3195. Uskokovic V, Kim MK, Li W, Habelitz S. PMID: 19177182.
      View in: PubMed   Mentions:
    41. The cooperative self-assembly of 25 and 23kDa amelogenins. J Struct Biol. 2008 Dec; 164(3):314-21. He X, Li W, Habelitz S. PMID: 18845261.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    42. Mechanical properties of mineralized collagen fibrils as influenced by demineralization. J Struct Biol. 2008 Jun; 162(3):404-10. Balooch M, Habelitz S, Kinney JH, Marshall SJ, Marshall GW. PMID: 18467127.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    43. Peritubular dentin lacks piezoelectricity. J Dent Res. 2007 Sep; 86(9):908-11. Habelitz S, Rodriguez BJ, Marshall SJ, Marshall GW, Kalinin SV, Gruverman A. PMID: 17720865.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    44. Elevated TGF-beta2 signaling in dentin results in sex related enamel defects. Arch Oral Biol. 2007 Sep; 52(9):814-21. Saeki K, Hilton JF, Alliston T, Habelitz S, Marshall SJ, Marshall GW, Denbesten P. PMID: 17391645.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    45. On the increasing fragility of human teeth with age: a deep-UV resonance Raman study. J Bone Miner Res. 2006 Dec; 21(12):1879-87. Ager JW, Nalla RK, Balooch G, Kim G, Pugach M, Habelitz S, Marshall GW, Kinney JH, Ritchie RO. PMID: 17002558.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    46. High-resolution imaging of proteins in human teeth by scanning probe microscopy. Biochem Biophys Res Commun. 2007 Jan 05; 352(1):142-6. Gruverman A, Wu D, Rodriguez BJ, Kalinin SV, Habelitz S. PMID: 17112467.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    47. Effect of degradation rates of resorbable phosphate invert glasses on in vitro osteoblast proliferation. J Biomed Mater Res A. 2006 May; 77(2):213-9. Brauer DS, Rüssel C, Li W, Habelitz S. PMID: 16392127.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    48. Self-assembly and effect on crystal growth of the leucine-rich amelogenin peptide. Eur J Oral Sci. 2006 May; 114 Suppl 1:315-9; discussion 327-9, 382. Habelitz S, DenBesten PK, Marshall SJ, Marshall GW, Li W. PMID: 16674705.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    49. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res. 2006 Mar; 21(3):466-76. Lane NE, Yao W, Balooch M, Nalla RK, Balooch G, Habelitz S, Kinney JH, Bonewald LF. PMID: 16491295.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    50. Amelogenin control over apatite crystal growth is affected by the pH and degree of ionic saturation. Orthod Craniofac Res. 2005 Nov; 8(4):232-8. Habelitz S, Denbesten PK, Marshall SJ, Marshall GW, Li W. PMID: 16238603.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    51. Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans. Eukaryot Cell. 2005 Sep; 4(9):1562-73. Murillo LA, Newport G, Lan CY, Habelitz S, Dungan J, Agabian NM. PMID: 16151249.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    52. MEPE is downregulated as dental pulp stem cells differentiate. Arch Oral Biol. 2005 Nov; 50(11):923-8. Liu H, Li W, Shi S, Habelitz S, Gao C, Denbesten P. PMID: 16183369.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    53. Amelogenin-guided crystal growth on fluoroapatite glass-ceramics. J Dent Res. 2004 Sep; 83(9):698-702. Habelitz S, Kullar A, Marshall SJ, DenBesten PK, Balooch M, Marshall GW, Li W. PMID: 15329375.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    54. The effect of a self-etching primer on the continuous demineralization of dentin. Eur J Oral Sci. 2004 Aug; 112(4):376-83. Oliveira SS, Marshall SJ, Habelitz S, Gansky SA, Wilson RS, Marshall GW. PMID: 15279658.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    55. The importance of intrafibrillar mineralization of collagen on the mechanical properties of dentin. J Dent Res. 2003 Dec; 82(12):957-61. Kinney JH, Habelitz S, Marshall SJ, Marshall GW. PMID: 14630894.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    56. Dentin caries activity status related to hardness and elasticity. Eur J Oral Sci. 2003 Jun; 111(3):243-52. Zheng L, Hilton JF, Habelitz S, Marshall SJ, Marshall GW. PMID: 12786956.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    57. Nanoindentation and storage of teeth. J Biomech. 2002 Jul; 35(7):995-8. Habelitz S, Marshall GW, Balooch M, Marshall SJ. PMID: 12052404.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    58. In situ atomic force microscopy of partially demineralized human dentin collagen fibrils. J Struct Biol. 2002 Jun; 138(3):227-36. Habelitz S, Balooch M, Marshall SJ, Balooch G, Marshall GW. PMID: 12217661.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    59. The functional width of the dentino-enamel junction determined by AFM-based nanoscratching. J Struct Biol. 2001 Sep; 135(3):294-301. Habelitz S, Marshall SJ, Marshall GW, Balooch M. PMID: 11722169.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    60. Nanomechanical properties of hydrated carious human dentin. J Dent Res. 2001 Aug; 80(8):1768-71. Marshall GW, Habelitz S, Gallagher R, Balooch M, Balooch G, Marshall SJ. PMID: 11669491.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    61. Mechanical properties of human dental enamel on the nanometre scale. Arch Oral Biol. 2001 Feb; 46(2):173-83. Habelitz S, Marshall SJ, Marshall GW, Balooch M. PMID: 11163325.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
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