Stefan Habelitz, PhD

Title(s)Professor, Preventive & Restor Dent Sci
SchoolSchool of Dentistry
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral Studies2001School of Dentistry
    Friedrich Schiller University - Jena GermanyPhD1998Chemistry
    Friedrich-Alexander University, Erlangen-NurnbergMaster and Bachelor of Science1994Materials Engineering
    Collapse Awards and Honors
    NIH/NIDCR2016  - 2021R01-DE25709 Amyloids in Enamel Development
    NIH/NIDCR2012  - 2017RO1-DE16849 Dentin Structure, Demineralization and Remineralization
    NIH/NIDCR2013  - 2015R21-DE023422 A New Concept of Amelogenin-Guided Mineralization in Enamel
    NIH/NIDCR2010  - 2015RO1 DE 015821 Amelogenin degradation by MMP-20 in enamel (PI Wu Li)
    NIH/NIDCR2012  - 2014R21DE022634 Mimicking the Dentin-Pulp Complex In-Vitro

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Amyloids in Enamel Development
    NIH/NIDCR R01DE025709Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    A New Concept of Amelogenin-guided Mineralization in Enamel
    NIH/NIDCR R21DE023422Sep 4, 2013 - May 31, 2015
    Role: Principal Investigator
    Mimicking the Dentin-Pulp Complex In-Vitro
    NIH/NIDCR R21DE022634Apr 1, 2012 - Mar 31, 2014
    Role: Principal Investigator
    Recombinant Amelogenin Matrices for Apatite Nanofibers
    NIH/NIDCR R01DE017529Jul 6, 2007 - Apr 30, 2012
    Role: Principal Investigator
    Dentin Structure, Demineralization and Remineralization
    NIH/NIDCR R01DE016849Jul 1, 2005 - Jun 30, 2017
    Role: Co-Principal Investigator
    Biomimetic Synthesis of an Enamel-Like Material
    NIH/NIDCR R21DE015416Aug 4, 2003 - May 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bacino M, Girn V, Nurrohman H, Saeki K, Marshall SJ, Gower L, Saeed E, Stewart R, Le T, Marshall GW, Habelitz S. Integrating the PILP-mineralization process into a restorative dental treatment. Dent Mater. 2019 Jan; 35(1):53-63. PMID: 30545611.
      View in: PubMed
    2. Engelberth SA, Bacino MS, Sandhu S, Li W, Bonde J, Habelitz S. Progression of Self-Assembly of Amelogenin Protein Supramolecular Structures in Simulated Enamel Fluid. Biomacromolecules. 2018 Oct 08; 19(10):3917-3924. PMID: 30114917.
      View in: PubMed
    3. Saxena N, Cremer MA, Dolling ES, Nurrohman H, Habelitz S, Marshall GW, Gower LB. Influence of fluoride on the mineralization of collagen via the polymer-induced liquid-precursor (PILP) process. Dent Mater. 2018 09; 34(9):1378-1390. PMID: 29935767.
      View in: PubMed
    4. Nurrohman H, Carneiro KMM, Hellgeth J, Saeki K, Marshall SJ, Marshall GW, Habelitz S. The role of protease inhibitors on the remineralization of demineralized dentin using the PILP method. PLoS One. 2017; 12(11):e0188277. PMID: 29182665.
      View in: PubMed
    5. Lacruz RS, Habelitz S, Wright JT, Paine ML. DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE. Physiol Rev. 2017 07 01; 97(3):939-993. PMID: 28468833.
      View in: PubMed
    6. Saeki K, Chien YC, Nonomura G, Chin AF, Habelitz S, Gower LB, Marshall SJ, Marshall GW. Recovery after PILP remineralization of dentin lesions created with two cariogenic acids. Arch Oral Biol. 2017 Oct; 82:194-202. PMID: 28647649.
      View in: PubMed
    7. Carneiro KM, Zhai H, Zhu L, Horst JA, Sitlin M, Nguyen M, Wagner M, Simpliciano C, Milder M, Chen CL, Ashby P, Bonde J, Li W, Habelitz S. Amyloid-like ribbons of amelogenins in enamel mineralization. Sci Rep. 2016 Mar 24; 6:23105. PMID: 27009419; PMCID: PMC4806362.
    8. Nurrohman, Hamid; Saeki, Kunkio; Carneiro, Karina M. M.; Chien Y.C., Djomehri, Sabra; Ho, Sunita P.; Qin, Chunlin; Marshall, Sally J.; Marshall, Grayson W. and Habelitz, Stefan. .Repair of dentin defects from DSPP knockout mice by PILP mineralization. J. Mater. Res. 2016; 31(3):321-327 .
    9. Nurrohman H, Saeki K, Carneiro K, Chien YC, Djomehri S, Ho SP, Qin C, Marshall SJ, Gower LB, Marshall GW, Habelitz S. Repair of dentin defects from DSPP knockout mice by PILP mineralization. J Mater Res. 2016 Feb 15; 31(3):321-327. PMID: 27239097.
      View in: PubMed
    10. Chien YC, Burwell AK, Saeki K, Fernandez-Martinez A, Pugach MK, Nonomura G, Habelitz S, Ho SP, Rapozo-Hilo M, Featherstone JD, Marshall SJ, Marshall GW. Distinct decalcification process of dentin by different cariogenic organic acids: Kinetics, ultrastructure and mechanical properties. Arch Oral Biol. 2016 Mar; 63:93-105. PMID: 26745819.
      View in: PubMed
    11. Habelitz S. Materials engineering by ameloblasts. J Dent Res. 2015 Jun; 94(6):759-67. PMID: 25800708.
      View in: PubMed
    12. Sanii B, Martinez-Avila O, Simpliciano C, Zuckermann RN, Habelitz S. Matching 4.7-Å XRD spacing in amelogenin nanoribbons and enamel matrix. J Dent Res. 2014 Sep; 93(9):918-22. PMID: 25048248; PMCID: PMC4213250.
    13. Denning D, Paukshto MV, Habelitz S, Rodriguez BJ. Piezoelectric properties of aligned collagen membranes. J Biomed Mater Res B Appl Biomater. 2014 Feb; 102(2):284-92. PMID: 24030958.
      View in: PubMed
    14. Khan F, Liu H, Reyes A, Witkowska HE, Martinez-Avila O, Zhu L, Li W, Habelitz S. The proteolytic processing of amelogenin by enamel matrix metalloproteinase (MMP-20) is controlled by mineral ions. Biochim Biophys Acta. 2013 Mar; 1830(3):2600-7. PMID: 23201201; PMCID: PMC4037249.
    15. Martinez-Avila O, Wu S, Kim SJ, Cheng Y, Khan F, Samudrala R, Sali A, Horst JA, Habelitz S. Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils. Biomacromolecules. 2012 Nov 12; 13(11):3494-502. PMID: 22974364; PMCID: PMC3496023.
    16. Denning D, Alilat S, Habelitz S, Fertala A, Rodriguez BJ. Visualizing molecular polar order in tissues via electromechanical coupling. J Struct Biol. 2012 Dec; 180(3):409-19. PMID: 22985991; PMCID: PMC4409004.
    17. Burwell AK, Thula-Mata T, Gower LB, Habelitz S, Habeliz S, Kurylo M, Ho SP, Chien YC, Cheng J, Cheng NF, Gansky SA, Marshall SJ, Marshall GW. Functional remineralization of dentin lesions using polymer-induced liquid-precursor process. PLoS One. 2012; 7(6):e38852. PMID: 22719965.
      View in: PubMed
    18. Denning D, Abu-Rub MT, Zeugolis DI, Habelitz S, Pandit A, Fertala A, Rodriguez BJ. Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels. Acta Biomater. 2012 Aug; 8(8):3073-9. PMID: 22522132.
      View in: PubMed
    19. Khan F, Li W, Habelitz S. Biophysical characterization of synthetic amelogenin C-terminal peptides. Eur J Oral Sci. 2012 Apr; 120(2):113-22. PMID: 22409217; PMCID: PMC3306135.
    20. Martinez-Avila OM, Wu S, Cheng Y, Lee R, Khan F, Habelitz S. Self-assembly of amelogenin proteins at the water-oil interface. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:75-82. PMID: 22243231.
      View in: PubMed
    21. Uskokovic V, Khan F, Liu H, Witkowska HE, Zhu L, Li W, Habelitz S. Hydrolysis of amelogenin by matrix metalloprotease-20 accelerates mineralization in vitro. Arch Oral Biol. 2011 Dec; 56(12):1548-59. PMID: 21774914; PMCID: PMC3221888.
    22. Uskokovic V, Li W, Habelitz S. Biomimetic Precipitation of Uniaxially Grown Calcium Phosphate Crystals from Full-Length Human Amelogenin Sols. J Bionic Eng. 2011 Jun 10; 8(2):114-121. PMID: 22140380.
      View in: PubMed
    23. Zhu L, Uskokovic V, Le T, Denbesten P, Huang Y, Habelitz S, Li W. Altered self-assembly and apatite binding of amelogenin induced by N-terminal proline mutation. Arch Oral Biol. 2011 Apr; 56(4):331-6. PMID: 21081224; PMCID: PMC3427771.
    24. Bertassoni LE, Habelitz S, Marshall SJ, Marshall GW. Mechanical recovery of dentin following remineralization in vitro--an indentation study. J Biomech. 2011 Jan 04; 44(1):176-81. PMID: 20926080; PMCID: PMC3003773.
    25. Uskokovic V, Odsinada R, Djordjevic S, Habelitz S. Dynamic light scattering and zeta potential of colloidal mixtures of amelogenin and hydroxyapatite in calcium and phosphate rich ionic milieus. Arch Oral Biol. 2011 Jun; 56(6):521-32. PMID: 21146151; PMCID: PMC3098925.
    26. Uskokovic V, Li W, Habelitz S. Amelogenin as a Promoter of Nucleation and Crystal Growth of Apatite. J Cryst Growth. 2011 Feb 01; 316(1):106-117. PMID: 30828107.
      View in: PubMed
    27. He X, Wu S, Martinez-Avila O, Cheng Y, Habelitz S. Self-aligning amelogenin nanoribbons in oil-water system. J Struct Biol. 2011 Apr; 174(1):203-12. PMID: 21134461; PMCID: PMC3204882.
    28. Bertassoni LE, Habelitz S, Pugach M, Soares PC, Marshall SJ, Marshall GW. Evaluation of surface structural and mechanical changes following remineralization of dentin. Scanning. 2010 Sep-Oct; 32(5):312-9. PMID: 20853406; PMCID: PMC2981622.
    29. Bechtle S, Fett T, Rizzi G, Habelitz S, Klocke A, Schneider GA. Crack arrest within teeth at the dentinoenamel junction caused by elastic modulus mismatch. Biomaterials. 2010 May; 31(14):4238-47. PMID: 20167362.
      View in: PubMed
    30. Bechtle S, Fett T, Rizzi G, Habelitz S, Schneider GA. Mixed-mode stress intensity factors for kink cracks with finite kink length loaded in tension and bending: application to dentin and enamel. J Mech Behav Biomed Mater. 2010 May; 3(4):303-12. PMID: 20346898.
      View in: PubMed
    31. Uskokovic V, Castiglione Z, Cubas P, Zhu L, Li W, Habelitz S. Zeta-potential and particle size analysis of human amelogenins. J Dent Res. 2010 Feb; 89(2):149-53. PMID: 20040742; PMCID: PMC3318063.
    32. Bechtle S, Habelitz S, Klocke A, Fett T, Schneider GA. The fracture behaviour of dental enamel. Biomaterials. 2010 Jan; 31(2):375-84. PMID: 19793611.
      View in: PubMed
    33. Rodriguez BJ, Jesse S, Habelitz S, Proksch R, Kalinin SV. Intermittent contact mode piezoresponse force microscopy in a liquid environment. Nanotechnology. 2009 May 13; 20(19):195701. PMID: 19420645.
      View in: PubMed
    34. Bertassoni LE, Habelitz S, Kinney JH, Marshall SJ, Marshall GW. Biomechanical perspective on the remineralization of dentin. Caries Res. 2009; 43(1):70-7. PMID: 19208991; PMCID: PMC2698028.
    35. Uskokovic V, Kim MK, Li W, Habelitz S. Enzymatic Processing of Amelogenin during Continuous Crystallization of Apatite. J Mater Res. 2008 Dec; 23(12):3184-3195. PMID: 19177182.
      View in: PubMed
    36. He X, Li W, Habelitz S. The cooperative self-assembly of 25 and 23kDa amelogenins. J Struct Biol. 2008 Dec; 164(3):314-21. PMID: 18845261; PMCID: PMC2694131.
    37. Balooch M, Habelitz S, Kinney JH, Marshall SJ, Marshall GW. Mechanical properties of mineralized collagen fibrils as influenced by demineralization. J Struct Biol. 2008 Jun; 162(3):404-10. PMID: 18467127; PMCID: PMC2697659.
    38. Habelitz S, Rodriguez BJ, Marshall SJ, Marshall GW, Kalinin SV, Gruverman A. Peritubular dentin lacks piezoelectricity. J Dent Res. 2007 Sep; 86(9):908-11. PMID: 17720865; PMCID: PMC2699430.
    39. Saeki K, Hilton JF, Alliston T, Habelitz S, Marshall SJ, Marshall GW, Denbesten P. Elevated TGF-beta2 signaling in dentin results in sex related enamel defects. Arch Oral Biol. 2007 Sep; 52(9):814-21. PMID: 17391645; PMCID: PMC2043093.
    40. Ager JW, Nalla RK, Balooch G, Kim G, Pugach M, Habelitz S, Marshall GW, Kinney JH, Ritchie RO. On the increasing fragility of human teeth with age: a deep-UV resonance Raman study. J Bone Miner Res. 2006 Dec; 21(12):1879-87. PMID: 17002558.
      View in: PubMed
    41. Gruverman A, Wu D, Rodriguez BJ, Kalinin SV, Habelitz S. High-resolution imaging of proteins in human teeth by scanning probe microscopy. Biochem Biophys Res Commun. 2007 Jan 05; 352(1):142-6. PMID: 17112467.
      View in: PubMed
    42. Brauer DS, Rüssel C, Li W, Habelitz S. Effect of degradation rates of resorbable phosphate invert glasses on in vitro osteoblast proliferation. J Biomed Mater Res A. 2006 May; 77(2):213-9. PMID: 16392127.
      View in: PubMed
    43. Habelitz S, DenBesten PK, Marshall SJ, Marshall GW, Li W. Self-assembly and effect on crystal growth of the leucine-rich amelogenin peptide. Eur J Oral Sci. 2006 May; 114 Suppl 1:315-9; discussion 327-9, 382. PMID: 16674705.
      View in: PubMed
    44. Lane NE, Yao W, Balooch M, Nalla RK, Balooch G, Habelitz S, Kinney JH, Bonewald LF. Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res. 2006 Mar; 21(3):466-76. PMID: 16491295; PMCID: PMC1797152.
    45. Habelitz S, Denbesten PK, Marshall SJ, Marshall GW, Li W. Amelogenin control over apatite crystal growth is affected by the pH and degree of ionic saturation. Orthod Craniofac Res. 2005 Nov; 8(4):232-8. PMID: 16238603.
      View in: PubMed
    46. Murillo LA, Newport G, Lan CY, Habelitz S, Dungan J, Agabian NM. Genome-wide transcription profiling of the early phase of biofilm formation by Candida albicans. Eukaryot Cell. 2005 Sep; 4(9):1562-73. PMID: 16151249; PMCID: PMC1214198.
    47. Liu H, Li W, Shi S, Habelitz S, Gao C, Denbesten P. MEPE is downregulated as dental pulp stem cells differentiate. Arch Oral Biol. 2005 Nov; 50(11):923-8. PMID: 16183369.
      View in: PubMed
    48. Habelitz S, Kullar A, Marshall SJ, DenBesten PK, Balooch M, Marshall GW, Li W. Amelogenin-guided crystal growth on fluoroapatite glass-ceramics. J Dent Res. 2004 Sep; 83(9):698-702. PMID: 15329375.
      View in: PubMed
    49. Oliveira SS, Marshall SJ, Habelitz S, Gansky SA, Wilson RS, Marshall GW. The effect of a self-etching primer on the continuous demineralization of dentin. Eur J Oral Sci. 2004 Aug; 112(4):376-83. PMID: 15279658.
      View in: PubMed
    50. Kinney JH, Habelitz S, Marshall SJ, Marshall GW. The importance of intrafibrillar mineralization of collagen on the mechanical properties of dentin. J Dent Res. 2003 Dec; 82(12):957-61. PMID: 14630894.
      View in: PubMed
    51. Zheng L, Hilton JF, Habelitz S, Marshall SJ, Marshall GW. Dentin caries activity status related to hardness and elasticity. Eur J Oral Sci. 2003 Jun; 111(3):243-52. PMID: 12786956.
      View in: PubMed
    52. Habelitz S, Marshall GW, Balooch M, Marshall SJ. Nanoindentation and storage of teeth. J Biomech. 2002 Jul; 35(7):995-8. PMID: 12052404.
      View in: PubMed
    53. Habelitz S, Balooch M, Marshall SJ, Balooch G, Marshall GW. In situ atomic force microscopy of partially demineralized human dentin collagen fibrils. J Struct Biol. 2002 Jun; 138(3):227-36. PMID: 12217661.
      View in: PubMed
    54. Habelitz S, Marshall SJ, Marshall GW, Balooch M. The functional width of the dentino-enamel junction determined by AFM-based nanoscratching. J Struct Biol. 2001 Sep; 135(3):294-301. PMID: 11722169.
      View in: PubMed
    55. Marshall GW, Habelitz S, Gallagher R, Balooch M, Balooch G, Marshall SJ. Nanomechanical properties of hydrated carious human dentin. J Dent Res. 2001 Aug; 80(8):1768-71. PMID: 11669491.
      View in: PubMed
    56. Habelitz S, Marshall SJ, Marshall GW, Balooch M. Mechanical properties of human dental enamel on the nanometre scale. Arch Oral Biol. 2001 Feb; 46(2):173-83. PMID: 11163325.
      View in: PubMed