Loading...

Sunita Ho, MS, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPreventive & Restor Dent Sci
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-514-2818
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Mechanical loads manifest into strains within tissues and interfaces of an organ. Strains within tissues are transduced by the cells to produce the needed extracellular matrix proteins to meet functional demands. This is the general philosophy of research in my laboratory which is within the Division of Biomaterials and Bioengineering. Our lab has a strong focus on mechanics, materials, and investigating adaptation of tissues/interfaces through spatiotemporal mapping of “mechano-responsiveness”. This is done by correlating mechanical strain induced biochemical signals at soft-hard tissue interfaces using several model systems including the bone-ligament-tooth fibrous joint.

    Due to the interdisciplinary nature of research, my laboratory is extended to the Molecular Foundry of Lawrence Berkeley National Laboratory, and Stanford Synchrotron Radiation Lightsource (SSRL) at Stanford Linear Accelerator Center (SLAC) with the help of NIH and DOE funded/peer-reviewed proposals. Mapping of biochemical expressions, physical properties of load bearing tissues, and biomechanics of organs are performed at UCSF, and as a guest scientist at the national laboratories/facilities.


    Collapse Research 
    Collapse Research Activities and Funding
    Multiscale form and function can predict renal biomineralization
    NIH/NIDDK R21DK109912Jul 11, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Load-mediated Adaptation of the Bone-PDL-Tooth Complex in Vertebrates
    NIH R01DE022032Feb 9, 2012 - Jan 31, 2017
    Role: Principal Investigator
    High Resolution Non-Invasive Imaging of Oral and Craniofacial Tissues
    NIH S10RR026645Jul 15, 2010 - Jul 14, 2011
    Role: Principal Investigator
    Biomimetic Properties of Cementum and Its Interfaces
    NIH R00DE018212Jul 1, 2008 - Jun 30, 2012
    Role: Principal Investigator
    Biomimetic Properties of Cementum and its Interfaces
    NIH K99DE018212Jul 1, 2007 - Jun 30, 2008
    Role: Principal Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Jeremy D. Lin, Andrew T. Jang, Michael P. Kurylo, Jonathan Hurng, Feifei Yang, Lynn Yang, Arvin Pal, Ling Chen, Sunita P. Ho.Periodontal Ligament Entheses and their Adaptive Role in the Context of Dentoalveolar Joint Function. Dental Materials (Invited Submission; under review). 2017.
    2. Andrew T. Jang, Ling Chen, Alex R. Shimotake, William Landis, Virginia Altoe, Shaul Aloni, Mark Ryder, Sunita P. Ho .A Force on the Crown and Tug of War in the Periodontal Complex. Journal of Dental Research (Invited Submission, under review). 2017.
    3. A. Pal, L. Chen, L. Yang, F. Yang, B.Meng, A.H. Jheon, S.P. Ho .Micro-anatomical responses in the periodontal complex to calibrated orthodontic forces on the crown. Orthodontics and Craniofacial Research (Invited Submission; under review). 2017.
    4. Hsi RS, Ramaswamy K, Ho S, Stoller ML. The origins of urinary stone disease: upstream mineral formations initiate downstream Randall's plaque. BJU Int. 2017 Jan; 119(1):177-184. PMID: 27306864.
      View in: PubMed
    5. Nakano Y, Le MH, Abduweli D, Ho S, Ryazanova LV, Hu Z, Ryazanov AG, Den Besten PK, Zhang Y. A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues. Front Physiol. 2016; 7:258. PMID: 27458382; PMCID: PMC4934143.
      View in: PubMed, PubMed Central
    6. Jang AT, Merkle AP, Fahey KP, Gansky SA, Ho S. Multiscale biomechanical responses of adapted bone-periodontal ligament-tooth fibrous joints. Bone. 2015 Dec; 81:196-207. PMID: 26151121.
      View in: PubMed
    7. Du J, Lee JH, Jang AT, Gu A, Hossaini-Zadeh M, Prevost R, Curtis DA, Ho S. Biomechanics and strain mapping in bone as related to immediately-loaded dental implants. J Biomech. 2015 Sep 18; 48(12):3486-94. PMID: 26162549; PMCID: PMC4663100.
      View in: PubMed, PubMed Central
    8. Kathryn Grandfield, Ralf-Peter Herber, Ling Chen, Sabra Djomehri, Caleb Tam, Ji-Hyun Lee, Evan Brown, Wood R.Woolwine III, Don Curtis, Mark Ryder, JimSchuck, Samuel Webb, William Landis, Sunita P. Ho.Strain-guided mineralization in the bone–PDL–cementum complex of a rat periodontium. Bone Reports. 2015; 3:20-31.
      View Publication
    9. Djomehri SI, Candell S, Case T, Browning A, Marshall GW, Yun W, Lau SH, Webb S, Ho S. Mineral density volume gradients in normal and diseased human tissues. PLoS One. 2015; 10(4):e0121611. PMID: 25856386; PMCID: PMC4391782.
      View in: PubMed, PubMed Central
    10. Zhang H, Jiang Y, Qin C, Liu Y, Ho S, Feng JQ. Essential role of osterix for tooth root but not crown dentin formation. J Bone Miner Res. 2015 Apr; 30(4):742-6. PMID: 25349111; PMCID: PMC4617775.
      View in: PubMed, PubMed Central
    11. Ji-Hyun Lee, Brian A. Pryce, Ronen Schweitzer, Mark I. Ryder, Sunita P. Ho.Differentiating Zones at Periodontal Ligament-Bone and Periodontal Ligament-Cementum Entheses. Journal of Periodontal Research. 2015.
    12. Ren Y, Han X, Ho S, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ. Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model. FASEB J. 2015 Jul; 29(7):2702-11. PMID: 25757567; PMCID: PMC4478802.
      View in: PubMed, PubMed Central
    13. Zhang Y, Kim JY, Horst O, Nakano Y, Zhu L, Radlanski RJ, Ho S, Den Besten PK. Fluorosed mouse ameloblasts have increased SATB1 retention and Gaq activity. PLoS One. 2014; 9(8):e103994. PMID: 25090413; PMCID: PMC4121220.
      View in: PubMed, PubMed Central
    14. Grandfield K, Chattah NL, Djomehri S, Eidelmann N, Eichmiller FC, Webb S, Schuck PJ, Nweeia M, Ho S. The narwhal (Monodon monoceros) cementum-dentin junction: a functionally graded biointerphase. Proc Inst Mech Eng H. 2014 Aug; 228(8):754-67. PMID: 25205746.
      View in: PubMed
    15. Jang AT, Lin JD, Choi RM, Choi EM, Seto ML, Ryder MI, Gansky SA, Curtis DA, Ho S. Adaptive properties of human cementum and cementum dentin junction with age. J Mech Behav Biomed Mater. 2014 Nov; 39:184-96. PMID: 25133753; PMCID: PMC4265544.
      View in: PubMed, PubMed Central
    16. Jang AT, Lin JD, Seo Y, Etchin S, Merkle A, Fahey K, Ho S. In situ compressive loading and correlative noninvasive imaging of the bone-periodontal ligament-tooth fibrous joint. J Vis Exp. 2014 Mar 07; (85). PMID: 24638035; PMCID: PMC4144414.
      View in: PubMed, PubMed Central
    17. Lin JD, Lee J, Ozcoban H, Schneider GA, Ho S. Biomechanical adaptation of the bone-periodontal ligament (PDL)-tooth fibrous joint as a consequence of disease. J Biomech. 2014 Jun 27; 47(9):2102-14. PMID: 24332618; PMCID: PMC4021007.
      View in: PubMed, PubMed Central
    18. Y-C Chien, A.K. Burwell, K. Saeki, A. Fernandez-Martinez, M.K. Pugach, G. Nonomura, S. Habelitz, S.P. Ho, M. Rapozo-Hilo, J.D. Featherstone, S.J. Marshall and G.W. Marshall .Acetic and lactic acids create different artificial dentin lesions: kinetics, ultrastructure and mechanical properties (under review). 2013.
    19. Ho S, Kurylo MP, Grandfield K, Hurng J, Herber RP, Ryder MI, Altoe V, Aloni S, Feng JQ, Webb S, Marshall GW, Curtis D, Andrews JC, Pianetta P. The plastic nature of the human bone-periodontal ligament-tooth fibrous joint. Bone. 2013 Dec; 57(2):455-67. PMID: 24063947; PMCID: PMC3938967.
      View in: PubMed, PubMed Central
    20. Lee JH, Lin JD, Fong JI, Ryder MI, Ho S. The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model. Biomed Res Int. 2013; 2013:876316. PMID: 23936854; PMCID: PMC3713652.
      View in: PubMed, PubMed Central
    21. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52. PMID: 23728424; PMCID: PMC3735916.
      View in: PubMed, PubMed Central
    22. Lin, J.D. and Aloni, S. and Altoe, V. and Webb, S.M. and Ryder, M.I. and Ho, S.P.Elastic discontinuity due to ectopic calcification in a human fibrous joint. Acta Biomaterilia. 2013; 1(9):4787-4795.
    23. Lin, J.D. and Özcoban, H. and Greene, J.P. and Jang, A.T. and Djomehri, S.I. and Fahey, K.P. and Hunter, L.L. and Schneider, G.A. and Ho, S.P. .Biomechanics of a bone-periodontal ligament-tooth fibrous joint. Journal of Biomechanics. 2013; (46):443-449.
    24. Lin JD, Özcoban H, Greene JP, Jang AT, Djomehri SI, Fahey KP, Hunter LL, Schneider GA, Ho S. Biomechanics of a bone-periodontal ligament-tooth fibrous joint. J Biomech. 2013 Feb 01; 46(3):443-9. PMID: 23219279; PMCID: PMC3690590.
      View in: PubMed, PubMed Central
    25. Tang SY, Herber RP, Ho S, Alliston T. Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res. 2012 Sep; 27(9):1936-50. PMID: 22549931; PMCID: PMC3415585.
      View in: PubMed, PubMed Central
    26. Burwell AK, Thula-Mata T, Gower LB, Habelitz S, Habeliz S, Kurylo M, Ho S, Chien YC, Cheng J, Cheng NF, Gansky SA, Marshall SJ, Marshall GW. Functional remineralization of dentin lesions using polymer-induced liquid-precursor process. PLoS One. 2012; 7(6):e38852. PMID: 22719965.
      View in: PubMed
    27. Leong NL, Hurng JM, Djomehri SI, Gansky SA, Ryder MI, Ho S. Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system. PLoS One. 2012; 7(4):e35980. PMID: 22558292; PMCID: PMC3340399.
      View in: PubMed, PubMed Central
    28. Chiu, R. and Li, W. and Herber, R.P. and Marshall, S.J. and Young, M. and Ho, S.P.Effects of biglycan on physico-chemical properties of ligament-mineralized tissue attachment sites. Archives of Oral Biology. 2012; 57(2):177-187.
    29. Leong, N.L. and Hurng, J.M. and Djomehri, S.I. and Gansky, S.A. and Ryder, M.I. and Ho, S.P., .PLoS One. Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system. 2012; 7(4).
    30. Herber, R, Fong, J, Lucas, S & Ho, S.Imaging an Adapted Dentoalveolar Complex. Anatomy Research International. 2012; 24(11):3482-13.
    31. Niver EL, Leong N, Greene J, Curtis D, Ryder MI, Ho S. Reduced functional loads alter the physical characteristics of the bone-periodontal ligament-cementum complex. J Periodontal Res. 2011 Dec; 46(6):730-41. PMID: 21848615; PMCID: PMC3200425.
      View in: PubMed, PubMed Central
    32. Hurng JM, Kurylo MP, Marshall GW, Webb SM, Ryder MI, Ho S. Discontinuities in the human bone-PDL-cementum complex. Biomaterials. 2011 Oct; 32(29):7106-17. PMID: 21774982; PMCID: PMC3185383.
      View in: PubMed, PubMed Central
    33. Zhang Y, Kim SO, Opsahl-Vital S, Ho S, Souron JB, Kim C, Giles K, Den Besten PK. Multiple effects of the cellular prion protein on tooth development. Int J Dev Biol. 2011; 55(10-12):953-60. PMID: 22252492.
      View in: PubMed
    34. Ho S, Kurylo MP, Fong TK, Lee SS, Wagner HD, Ryder MI, Marshall GW. The biomechanical characteristics of the bone-periodontal ligament-cementum complex. Biomaterials. 2010 Sep; 31(25):6635-46. PMID: 20541802; PMCID: PMC2925235.
      View in: PubMed, PubMed Central
    35. Vaderhobli RM, White JM, Le C, Ho S, Jordan R. In vitro study of the soft tissue effects of microsecond-pulsed CO(2) laser parameters during soft tissue incision and sulcular debridement. Lasers Surg Med. 2010 Mar; 42(3):257-63. PMID: 20333737.
      View in: PubMed
    36. Ho S, Senkyrikova P, Marshall GW, Yun W, Wang Y, Karan K, Li C, Marshall SJ. Structure, chemical composition and mechanical properties of coronal cementum in human deciduous molars. Dent Mater. 2009 Oct; 25(10):1195-204. PMID: 19464049; PMCID: PMC2782750.
      View in: PubMed, PubMed Central
    37. Varanasi, V.G. and Saiz, E. and Loomer, P.M. and Ancheta, B. and Uritani, N. and Ho, S.P. and Tomsia, A.P. and Marshall, S.J. and Marshall, G.W.Enhanced osteocalcin expression by osteoblast-like cells (MC3T3-E1) exposed to bioactive coating glass (SiO2-CaO-P2O5-MgO-K2O-Na2O system) ions. Acta Biomaterilia. 2009; 5(9):3536-3547.
    38. Ho S, Yu B, Yun W, Marshall GW, Ryder MI, Marshall SJ. Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin. Acta Biomater. 2009 Feb; 5(2):707-18. PMID: 18829402; PMCID: PMC2685077.
      View in: PubMed, PubMed Central
    39. Ho S, Marshall SJ, Ryder MI, Marshall GW. The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium. Biomaterials. 2007 Dec; 28(35):5238-45. PMID: 17870156; PMCID: PMC2423002.
      View in: PubMed, PubMed Central
    40. Caldwell Rebecca, LaBerge Martine, and Ho Sunita.Advances in Polymeric Biomaterials. Surface Modification of Articulating Surfaces and Tribological Evaluation. 2006; 303-335.
    41. A.C. Clark, S. P. Ho, M. LaBerge.Tribology International. Conductive Composite of UHMWPE and CB as a Dynamic Contact Analysis Sensor. 2006; (39):1327-1335.
    42. Ho S, Sulyanto RM, Marshall SJ, Marshall GW. The cementum-dentin junction also contains glycosaminoglycans and collagen fibrils. J Struct Biol. 2005 Jul; 151(1):69-78. PMID: 15964205.
      View in: PubMed
    43. Ho S, Balooch M, Marshall SJ, Marshall GW. Local properties of a functionally graded interphase between cementum and dentin. J Biomed Mater Res A. 2004 Sep 01; 70(3):480-9. PMID: 15293322.
      View in: PubMed
    44. Ho S, Goodis H, Balooch M, Nonomura G, Marshall SJ, Marshall G. The effect of sample preparation technique on determination of structure and nanomechanical properties of human cementum hard tissue. Biomaterials. 2004 Aug; 25(19):4847-57. PMID: 15120532.
      View in: PubMed
    45. Ho S, Joseph PF, Drews MJ, Boland T, LaBerge M. Experimental and numerical modeling of variable friction between nanoregions in coventional and crosslinked UHMWPE. J Biomech Eng. 2004 Feb; 126(1):111-9. PMID: 15171137.
      View in: PubMed
    46. Ho S, Balooch M, Goodis HE, Marshall GW, Marshall SJ. Ultrastructure and nanomechanical properties of cementum dentin junction. J Biomed Mater Res A. 2004 Feb 01; 68(2):343-51. PMID: 14704976.
      View in: PubMed
    47. Ho S, Nakabayashi N, Iwasaki Y, Boland T, LaBerge M. Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications. Biomaterials. 2003 Dec; 24(28):5121-9. PMID: 14568428.
      View in: PubMed
    48. Ho S, Riester L, Drews M, Boland T, LaBerge M. Nanoindentation properties of compression-moulded ultra-high molecular weight polyethylene. Proc Inst Mech Eng H. 2003; 217(5):357-66. PMID: 14558648.
      View in: PubMed
    49. Caldwell RA, Woodell JE, Ho S, Shalaby SW, Boland T, Langan EM, LaBerge M. In vitro evaluation of phosphonylated low-density polyethylene for vascular applications. J Biomed Mater Res. 2002 Dec 15; 62(4):514-24. PMID: 12221699.
      View in: PubMed
    50. S. P. Ho, R. W. Carpick, T. Boland, M. LaBerge.Wear. Nanotribology of CoCr-UHMWPE TJR Prosthesis Using Atomic Force Microscopy. 2002; 11-12(253):1145-1155.
    51. Ho S, Riester L, Drews M, Boland T, LaBerge M. Effects of the sample preparation temperature on the nanostructure of compression moulded ultrahigh molecular weight polyethylene. Proc Inst Mech Eng H. 2002; 216(2):123-33. PMID: 12022419.
      View in: PubMed
    52. Ho, S.P. and Friedman, R.J. and LaBerge, M.Critical Reviews in Biomedical Engineering. Failure analysis of anatomic porous hip replacement (APR IIS). 1998; 26(5).
    53. Pullela S. V.Determination of the PULSTAR Reactor Neutron Energy Spectrum, Journal of Energy Conversion and Management. 1996.
    54. Sarma P. K., Sunita P. V.Interaction of Thermal-Radiation with Laminar Natural-Convection from a Horizontal Cylinder in Air, Warme und Stoffunbertragung-Thermo and Fluid Dynamics, 26(2), 65-69. 1991.
    Sunita's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (197) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (19) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    ↑