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Sunita Ho, MS, PhD

Title(s)Professor, Preventive & Restor Dent Sci
SchoolSchool of Dentistry
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-514-2818
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    Mechanical loads manifest into strains within tissues and interfaces of an organ. Strains within tissues are transduced by the cells to produce the needed extracellular matrix proteins to meet functional demands. This is the general philosophy of research in my laboratory which is within the Division of Biomaterials and Bioengineering. Our lab has a strong focus on mechanics, materials, and investigating adaptation of tissues/interfaces through spatiotemporal mapping of “mechano-responsiveness”. This is done by correlating mechanical strain induced biochemical signals at soft-hard tissue interfaces using several model systems including the bone-ligament-tooth fibrous joint.

    Due to the interdisciplinary nature of research, my laboratory is extended to the Molecular Foundry of Lawrence Berkeley National Laboratory, and Stanford Synchrotron Radiation Lightsource (SSRL) at Stanford Linear Accelerator Center (SLAC) with the help of NIH and DOE funded/peer-reviewed proposals. Mapping of biochemical expressions, physical properties of load bearing tissues, and biomechanics of organs are performed at UCSF, and as a guest scientist at the national laboratories/facilities.

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    Functional Competance of Dentoalveolar Joints in Vertebrates
    NIH/NIDCR 2 R01 DE022032 06A1Jun 19, 2020 - Jun 22, 2023
    Role: Principal Investigator
    Multiscale form and function can predict renal biomineralization
    NIH/NIDDK R21DK109912Jul 11, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Load-mediated Adaptation of the Bone-PDL-Tooth Complex in Vertebrates
    NIH R01DE022032Feb 9, 2012 - Jan 31, 2017
    Role: Principal Investigator
    High Resolution Non-Invasive Imaging of Oral and Craniofacial Tissues
    NIH S10RR026645Jul 15, 2010 - Jul 14, 2011
    Role: Principal Investigator
    Biomimetic Properties of Cementum and Its Interfaces
    NIH R00DE018212Jul 1, 2008 - Jun 30, 2012
    Role: Principal Investigator
    Biomimetic Properties of Cementum and its Interfaces
    NIH K99DE018212Jul 1, 2007 - Jun 30, 2008
    Role: Principal Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Re: Geobiology Reveals How Human Kidney Stones Dissolve In Vivo. Eur Urol. 2019 03; 75(3):532. Ho SP, Stoller ML. PMID: 30449699.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Architecture-Guided Fluid Flow Directs Renal Biomineralization. Sci Rep. 2018 09 21; 8(1):14157. Ho SP, Chen L, Allen FI, Hsi RS, Shimotake AR, Wiener SV, Kang M, Minor AM, Stoller ML. PMID: 30242165.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Micro-anatomical responses in the periodontal complex to calibrated orthodontic forces on the crown. Orthodontics and Craniofacial Research (Invited Submission; under review). 2017. A. Pal, L. Chen, L. Yang, F. Yang, B.Meng, A.H. Jheon, S.P. Ho ..
    4. A Force on the Crown and Tug of War in the Periodontal Complex. Journal of Dental Research (Invited Submission, under review). 2017. Andrew T. Jang, Ling Chen, Alex R. Shimotake, William Landis, Virginia Altoe, Shaul Aloni, Mark Ryder, Sunita P. Ho ..
    5. Periodontal Ligament Entheses and their Adaptive Role in the Context of Dentoalveolar Joint Function. Dental Materials (Invited Submission; under review). 2017. Jeremy D. Lin, Andrew T. Jang, Michael P. Kurylo, Jonathan Hurng, Feifei Yang, Lynn Yang, Arvin Pal, Ling Chen, Sunita P. Ho..
    6. The origins of urinary stone disease: upstream mineral formations initiate downstream Randall's plaque. BJU Int. 2017 Jan; 119(1):177-184. Hsi RS, Ramaswamy K, Ho SP, Stoller ML. PMID: 27306864.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues. Front Physiol. 2016; 7:258. Nakano Y, Le MH, Abduweli D, Ho SP, Ryazanova LV, Hu Z, Ryazanov AG, Den Besten PK, Zhang Y. PMID: 27458382.
      View in: PubMed   Mentions:
    8. Multiscale biomechanical responses of adapted bone-periodontal ligament-tooth fibrous joints. Bone. 2015 Dec; 81:196-207. Jang AT, Merkle AP, Fahey KP, Gansky SA, Ho SP. PMID: 26151121.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    9. Biomechanics and strain mapping in bone as related to immediately-loaded dental implants. J Biomech. 2015 Sep 18; 48(12):3486-94. Du J, Lee JH, Jang AT, Gu A, Hossaini-Zadeh M, Prevost R, Curtis DA, Ho SP. PMID: 26162549.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Strain-guided mineralization in the bone–PDL–cementum complex of a rat periodontium. Bone Reports. 2015; 3:20-31. Kathryn Grandfield, Ralf-Peter Herber, Ling Chen, Sabra Djomehri, Caleb Tam, Ji-Hyun Lee, Evan Brown, Wood R.Woolwine III, Don Curtis, Mark Ryder, JimSchuck, Samuel Webb, William Landis, Sunita P. Ho.. View Publication.
    11. Mineral density volume gradients in normal and diseased human tissues. PLoS One. 2015; 10(4):e0121611. Djomehri SI, Candell S, Case T, Browning A, Marshall GW, Yun W, Lau SH, Webb S, Ho SP. PMID: 25856386.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    12. Essential role of osterix for tooth root but not crown dentin formation. J Bone Miner Res. 2015 Apr; 30(4):742-6. Zhang H, Jiang Y, Qin C, Liu Y, Ho SP, Feng JQ. PMID: 25349111.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    13. Differentiating Zones at Periodontal Ligament-Bone and Periodontal Ligament-Cementum Entheses. Journal of Periodontal Research. 2015. Ji-Hyun Lee, Brian A. Pryce, Ronen Schweitzer, Mark I. Ryder, Sunita P. Ho..
    14. Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model. FASEB J. 2015 Jul; 29(7):2702-11. Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ. PMID: 25757567.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    15. Fluorosed mouse ameloblasts have increased SATB1 retention and Gaq activity. PLoS One. 2014; 9(8):e103994. Zhang Y, Kim JY, Horst O, Nakano Y, Zhu L, Radlanski RJ, Ho S, Den Besten PK. PMID: 25090413.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. The narwhal (Monodon monoceros) cementum-dentin junction: a functionally graded biointerphase. Proc Inst Mech Eng H. 2014 Aug; 228(8):754-67. Grandfield K, Chattah NL, Djomehri S, Eidelmann N, Eichmiller FC, Webb S, Schuck PJ, Nweeia M, Ho SP. PMID: 25205746.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    17. Adaptive properties of human cementum and cementum dentin junction with age. J Mech Behav Biomed Mater. 2014 Nov; 39:184-96. Jang AT, Lin JD, Choi RM, Choi EM, Seto ML, Ryder MI, Gansky SA, Curtis DA, Ho SP. PMID: 25133753.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. In situ compressive loading and correlative noninvasive imaging of the bone-periodontal ligament-tooth fibrous joint. J Vis Exp. 2014 Mar 07; (85). Jang AT, Lin JD, Seo Y, Etchin S, Merkle A, Fahey K, Ho SP. PMID: 24638035.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    19. Biomechanical adaptation of the bone-periodontal ligament (PDL)-tooth fibrous joint as a consequence of disease. J Biomech. 2014 Jun 27; 47(9):2102-14. Lin JD, Lee J, Ozcoban H, Schneider GA, Ho SP. PMID: 24332618.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    20. Acetic and lactic acids create different artificial dentin lesions: kinetics, ultrastructure and mechanical properties (under review). 2013. Y-C Chien, A.K. Burwell, K. Saeki, A. Fernandez-Martinez, M.K. Pugach, G. Nonomura, S. Habelitz, S.P. Ho, M. Rapozo-Hilo, J.D. Featherstone, S.J. Marshall and G.W. Marshall .
    21. The plastic nature of the human bone-periodontal ligament-tooth fibrous joint. Bone. 2013 Dec; 57(2):455-67. Ho SP, Kurylo MP, Grandfield K, Hurng J, Herber RP, Ryder MI, Altoe V, Aloni S, Feng JQ, Webb S, Marshall GW, Curtis D, Andrews JC, Pianetta P. PMID: 24063947.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    22. The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model. Biomed Res Int. 2013; 2013:876316. Lee JH, Lin JD, Fong JI, Ryder MI, Ho SP. PMID: 23936854.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    23. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52. Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. PMID: 23728424.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    24. Elastic discontinuity due to ectopic calcification in a human fibrous joint. Acta Biomaterilia. 2013; 1(9):4787-4795. Lin, J.D. and Aloni, S. and Altoe, V. and Webb, S.M. and Ryder, M.I. and Ho, S.P.
    25. Biomechanics of a bone-periodontal ligament-tooth fibrous joint. Journal of Biomechanics. 2013; (46):443-449. Lin, J.D. and Özcoban, H. and Greene, J.P. and Jang, A.T. and Djomehri, S.I. and Fahey, K.P. and Hunter, L.L. and Schneider, G.A. and Ho, S.P.
    26. Biomechanics of a bone-periodontal ligament-tooth fibrous joint. J Biomech. 2013 Feb 01; 46(3):443-9. Lin JD, Özcoban H, Greene JP, Jang AT, Djomehri SI, Fahey KP, Hunter LL, Schneider GA, Ho SP. PMID: 23219279.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    27. Matrix metalloproteinase-13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance. J Bone Miner Res. 2012 Sep; 27(9):1936-50. Tang SY, Herber RP, Ho SP, Alliston T. PMID: 22549931.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    28. Functional remineralization of dentin lesions using polymer-induced liquid-precursor process. PLoS One. 2012; 7(6):e38852. Burwell AK, Thula-Mata T, Gower LB, Habelitz S, Habeliz S, Kurylo M, Ho SP, Chien YC, Cheng J, Cheng NF, Gansky SA, Marshall SJ, Marshall GW. PMID: 22719965.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    29. Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system. PLoS One. 2012; 7(4):e35980. Leong NL, Hurng JM, Djomehri SI, Gansky SA, Ryder MI, Ho SP. PMID: 22558292.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    30. PLoS One. Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system. 2012; 7(4). Leong, N.L. and Hurng, J.M. and Djomehri, S.I. and Gansky, S.A. and Ryder, M.I. and Ho, S.P., .
    31. Effects of biglycan on physico-chemical properties of ligament-mineralized tissue attachment sites. Archives of Oral Biology. 2012; 57(2):177-187. Chiu, R. and Li, W. and Herber, R.P. and Marshall, S.J. and Young, M. and Ho, S.P.
    32. Imaging an Adapted Dentoalveolar Complex. Anatomy Research International. 2012; 24(11):3482-13. Herber, R, Fong, J, Lucas, S & Ho, S.
    33. Reduced functional loads alter the physical characteristics of the bone-periodontal ligament-cementum complex. J Periodontal Res. 2011 Dec; 46(6):730-41. Niver EL, Leong N, Greene J, Curtis D, Ryder MI, Ho SP. PMID: 21848615.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    34. Discontinuities in the human bone-PDL-cementum complex. Biomaterials. 2011 Oct; 32(29):7106-17. Hurng JM, Kurylo MP, Marshall GW, Webb SM, Ryder MI, Ho SP. PMID: 21774982.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Multiple effects of the cellular prion protein on tooth development. Int J Dev Biol. 2011; 55(10-12):953-60. Zhang Y, Kim SO, Opsahl-Vital S, Ho SP, Souron JB, Kim C, Giles K, Den Besten PK. PMID: 22252492.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    36. The biomechanical characteristics of the bone-periodontal ligament-cementum complex. Biomaterials. 2010 Sep; 31(25):6635-46. Ho SP, Kurylo MP, Fong TK, Lee SS, Wagner HD, Ryder MI, Marshall GW. PMID: 20541802.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    37. In vitro study of the soft tissue effects of microsecond-pulsed CO(2) laser parameters during soft tissue incision and sulcular debridement. Lasers Surg Med. 2010 Mar; 42(3):257-63. Vaderhobli RM, White JM, Le C, Ho S, Jordan R. PMID: 20333737.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    38. Structure, chemical composition and mechanical properties of coronal cementum in human deciduous molars. Dent Mater. 2009 Oct; 25(10):1195-204. Ho SP, Senkyrikova P, Marshall GW, Yun W, Wang Y, Karan K, Li C, Marshall SJ. PMID: 19464049.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    39. Enhanced osteocalcin expression by osteoblast-like cells (MC3T3-E1) exposed to bioactive coating glass (SiO2-CaO-P2O5-MgO-K2O-Na2O system) ions. Acta Biomaterilia. 2009; 5(9):3536-3547. Varanasi, V.G. and Saiz, E. and Loomer, P.M. and Ancheta, B. and Uritani, N. and Ho, S.P. and Tomsia, A.P. and Marshall, S.J. and Marshall, G.W.
    40. Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin. Acta Biomater. 2009 Feb; 5(2):707-18. Ho SP, Yu B, Yun W, Marshall GW, Ryder MI, Marshall SJ. PMID: 18829402.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    41. The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium. Biomaterials. 2007 Dec; 28(35):5238-45. Ho SP, Marshall SJ, Ryder MI, Marshall GW. PMID: 17870156.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    42. Tribology International. Conductive Composite of UHMWPE and CB as a Dynamic Contact Analysis Sensor. 2006; (39):1327-1335. A.C. Clark, S. P. Ho, M. LaBerge.
    43. Advances in Polymeric Biomaterials. Surface Modification of Articulating Surfaces and Tribological Evaluation. 2006; 303-335. Caldwell Rebecca, LaBerge Martine, and Ho Sunita..
    44. The cementum-dentin junction also contains glycosaminoglycans and collagen fibrils. J Struct Biol. 2005 Jul; 151(1):69-78. Ho SP, Sulyanto RM, Marshall SJ, Marshall GW. PMID: 15964205.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    45. Local properties of a functionally graded interphase between cementum and dentin. J Biomed Mater Res A. 2004 Sep 01; 70(3):480-9. Ho SP, Balooch M, Marshall SJ, Marshall GW. PMID: 15293322.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    46. The effect of sample preparation technique on determination of structure and nanomechanical properties of human cementum hard tissue. Biomaterials. 2004 Aug; 25(19):4847-57. Ho SP, Goodis H, Balooch M, Nonomura G, Marshall SJ, Marshall G. PMID: 15120532.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    47. Experimental and numerical modeling of variable friction between nanoregions in coventional and crosslinked UHMWPE. J Biomech Eng. 2004 Feb; 126(1):111-9. Ho SP, Joseph PF, Drews MJ, Boland T, LaBerge M. PMID: 15171137.
      View in: PubMed   Mentions: 2     Fields:    
    48. Ultrastructure and nanomechanical properties of cementum dentin junction. J Biomed Mater Res A. 2004 Feb 01; 68(2):343-51. Ho SP, Balooch M, Goodis HE, Marshall GW, Marshall SJ. PMID: 14704976.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    49. Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications. Biomaterials. 2003 Dec; 24(28):5121-9. Ho SP, Nakabayashi N, Iwasaki Y, Boland T, LaBerge M. PMID: 14568428.
      View in: PubMed   Mentions: 9     Fields:    
    50. Nanoindentation properties of compression-moulded ultra-high molecular weight polyethylene. Proc Inst Mech Eng H. 2003; 217(5):357-66. Ho SP, Riester L, Drews M, Boland T, LaBerge M. PMID: 14558648.
      View in: PubMed   Mentions: 2     Fields:    
    51. In vitro evaluation of phosphonylated low-density polyethylene for vascular applications. J Biomed Mater Res. 2002 Dec 15; 62(4):514-24. Caldwell RA, Woodell JE, Ho SP, Shalaby SW, Boland T, Langan EM, LaBerge M. PMID: 12221699.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    52. Effects of the sample preparation temperature on the nanostructure of compression moulded ultrahigh molecular weight polyethylene. Proc Inst Mech Eng H. 2002; 216(2):123-33. Ho SP, Riester L, Drews M, Boland T, LaBerge M. PMID: 12022419.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Wear. Nanotribology of CoCr-UHMWPE TJR Prosthesis Using Atomic Force Microscopy. 2002; 11-12(253):1145-1155. S. P. Ho, R. W. Carpick, T. Boland, M. LaBerge.
    54. Critical Reviews in Biomedical Engineering. Failure analysis of anatomic porous hip replacement (APR IIS). 1998; 26(5). Ho, S.P. and Friedman, R.J. and LaBerge, M.
    55. Determination of the PULSTAR Reactor Neutron Energy Spectrum, Journal of Energy Conversion and Management. 1996. Pullela S. V.
    56. Interaction of Thermal-Radiation with Laminar Natural-Convection from a Horizontal Cylinder in Air, Warme und Stoffunbertragung-Thermo and Fluid Dynamics, 26(2), 65-69. 1991. Sarma P. K., Sunita P. V.
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