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    Francesca Nesta Delling, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address555 Mission Bay Blvd South
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      Universita' di Brescia School of MedicineM.D.Medicine1998
      Universita' di Brescia School of Medicine; Spedali Civili BresciaInternMedicine1999
      Universita' di Ferrara School of Medicine; Arcispedale S.Anna FellowCardiovascular Medicine2001
      Cardiac Ultrasound Laboratory, Massachusetts General HospitalFellowEchocardiography2004
      Boston University Medical CenterResidentMedicine2007
      Beth Israel Deaconess Medical CenterFellowCardiovascular Medicine2010
      Harvard T.H. Chan School of Public HealthM.P.H.Public Health2016
      Collapse Awards and Honors
      American Heart Association2004Samuel A. Levine Young Clinical Investigator Award finalist

      Collapse Overview 
      Collapse Overview
      Dr Delling is a cardiologist with advanced training in echocardiography and cardiac magnetic resonance imaging (MRI). She completed internal medicine residency at Boston University Medical Center and cardiovascular and cardiac imaging fellowships at Beth Israel Deaconess Medical Center and Massachusetts General Hospital. Her clinical interests include valvular heart disease (with a focus on mitral valve prolapse), primary and secondary cardiomyopathies and sudden cardiac death related to valvular disease.

      Dr Delling's research has focused on mitral valve disease and the combined use of echocardiography, cardiac MRI, and molecular genetics as tools to better understand disease mechanisms and progression. She is currently an NIH-funded investigator (previously supported by the American Heart Association) with collaborators at the Framingham Heart Study and the Leducq MITRAL Network in Europe. Attended coursework essential for her research endeavors includes a Master in Public Health (Harvard T.H. Chan School of Public Health).

      Collapse Interests
      Mitral regurgitation, mitral valve prolapse, cardiomyopathy, tricuspid valve disease, aortic valve disease, sudden cardiac death.

      Collapse ORNG Applications 
      Collapse Faculty Mentoring
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bui AH, Roujol S, Foppa M, Kissinger KV, Goddu B, Hauser TH, Zimetbaum PJ, Ngo LH, Manning WJ, Nezafat R, Delling FN, et al. Diffuse myocardial fibrosis in patients with mitral valve prolapse and ventricular arrhythmia. Heart. 2016 Aug 11. PMID: 27515954.
        View in: PubMed
      2. Delling FN, Rong J, Larson MG, Lehman B, Fuller D, Osypiuk E, Stantchev P, Hackman B, Manning WJ, Benjamin EJ, Levine RA, Vasan RS. Evolution of Mitral Valve Prolapse: Insights From the Framingham Heart Study. Circulation. 2016 Apr 26; 133(17):1688-95. PMID: 27006478.
        View in: PubMed
      3. Delling FN, Hassan ZK, Piatkowski G, Tsao CW, Rajabali A, Markson LJ, Zimetbaum PJ, Manning WJ, Chang JD, Mukamal KJ. Tricuspid Regurgitation and Mortality in Patients With Transvenous Permanent Pacemaker Leads. Am J Cardiol. 2016 Mar 15; 117(6):988-92. PMID: 26833208.
        View in: PubMed
      4. Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Marec HL, Tourneau TL, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH. Mitral valve disease-morphology and mechanisms. Nat Rev Cardiol. 2015 Dec; 12(12):689-710. PMID: 26483167.
        View in: PubMed
      5. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Response to Letter Regarding Article, "Familial Clustering of Mitral Valve Prolapse in the Community". Circulation. 2015 Oct 6; 132(14):e187-8. PMID: 26438779; PMCID: PMC4620666 [Available on 10/06/16].
      6. Delling FN. Left Ventricular Ejection Index as a Marker of Early Myocardial Dysfunction in Primary Mitral Regurgitation: Novel or Old in Disguise? Circ Cardiovasc Imaging. 2015 Sep; 8(9):e003995. PMID: 26338880; PMCID: PMC4563999 [Available on 09/01/16].
      7. Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Jeunemaitre X. Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct; 47(10):1206-11. PMID: 26301497.
        View in: PubMed
      8. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 3; 525(7567):109-13. PMID: 26258302.
        View in: PubMed
      9. Motiwala SR, Delling FN. Assessment of mitral valve disease: a review of imaging modalities. Curr Treat Options Cardiovasc Med. 2015 Jul; 17(7):390. PMID: 25981195.
        View in: PubMed
      10. Delling FN, Vasan RS. Mitral valve prolapse and glaucoma: a 'floppy' perception? Heart. 2015 Apr; 101(8):584-5. PMID: 25637370.
        View in: PubMed
      11. Delling FN, Rong J, Larson MG, Lehman B, Osypiuk E, Stantchev P, Slaugenhaupt SA, Benjamin EJ, Levine RA, Vasan RS. Familial clustering of mitral valve prolapse in the community. Circulation. 2015 Jan 20; 131(3):263-8. PMID: 25361552; PMCID: PMC4301989 [Available on 01/20/16].
      12. Delling FN, Vasan RS. Epidemiology and pathophysiology of mitral valve prolapse: new insights into disease progression, genetics, and molecular basis. Circulation. 2014 May 27; 129(21):2158-70. PMID: 24867995; PMCID: PMC4052751.
      13. Delling FN, Gona P, Larson MG, Lehman B, Manning WJ, Levine RA, Benjamin EJ, Vasan RS. Mild expression of mitral valve prolapse in the Framingham offspring: expanding the phenotypic spectrum. J Am Soc Echocardiogr. 2014 Jan; 27(1):17-23. PMID: 24206636; PMCID: PMC4239996.
      14. Appelbaum E, Maron BJ, Adabag S, Hauser TH, Lesser JR, Haas TS, Riley AB, Harrigan CJ, Delling FN, Udelson JE, Gibson CM, Manning WJ, Maron MS. Intermediate-signal-intensity late gadolinium enhancement predicts ventricular tachyarrhythmias in patients with hypertrophic cardiomyopathy. Circ Cardiovasc Imaging. 2012 Jan; 5(1):78-85. PMID: 22135401.
        View in: PubMed
      15. Delling FN, Kang LL, Yeon SB, Kissinger KV, Goddu B, Manning WJ, Han Y. CMR predictors of mitral regurgitation in mitral valve prolapse. JACC Cardiovasc Imaging. 2010 Oct; 3(10):1037-45. PMID: 20947049.
        View in: PubMed
      16. Beeri R, Yosefy C, Guerrero JL, Nesta F, Abedat S, Chaput M, del Monte F, Handschumacher MD, Stroud R, Sullivan S, Pugatsch T, Gilon D, Vlahakes GJ, Spinale FG, Hajjar RJ, Levine RA. Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. J Am Coll Cardiol. 2008 Jan 29; 51(4):476-86. PMID: 18222360.
        View in: PubMed
      17. Delling FN, Sanborn DY, Levine RA, Picard MH, Fifer MA, Palacios IF, Lowry PA, Vlahakes GJ, Vaturi M, Hung J. Frequency and mechanism of persistent systolic anterior motion and mitral regurgitation after septal ablation in obstructive hypertrophic cardiomyopathy. Am J Cardiol. 2007 Dec 1; 100(11):1691-5. PMID: 18036370.
        View in: PubMed
      18. Syed Z, Leeds D, Curtis D, Nesta F, Levine RA, Guttag J. A framework for the analysis of acoustical cardiac signals. IEEE Trans Biomed Eng. 2007 Apr; 54(4):651-62. PMID: 17405372.
        View in: PubMed
      19. Syed Z, Curtis D, Guttag J, Nesta F, Levine RA. Software enhanced learning of cardiac auscultation. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:6105-8. PMID: 17946356.
        View in: PubMed
      20. Nesta F, Leyne M, Yosefy C, Simpson C, Dai D, Marshall JE, Hung J, Slaugenhaupt SA, Levine RA. New locus for autosomal dominant mitral valve prolapse on chromosome 13: clinical insights from genetic studies. Circulation. 2005 Sep 27; 112(13):2022-30. PMID: 16172273.
        View in: PubMed
      21. Sebag IA, Morgan JG, Handschumacher MD, Marshall JE, Nesta F, Hung J, Picard MH, Levine RA. Usefulness of three-dimensionally guided assessment of mitral stenosis using matrix-array ultrasound. Am J Cardiol. 2005 Oct 15; 96(8):1151-6. PMID: 16214455.
        View in: PubMed
      22. Dember LM, Shepard JA, Nesta F, Stone JR. Case records of the Massachusetts General Hospital. Case 15-2005. An 80-year-old man with shortness of breath, edema, and proteinuria. N Engl J Med. 2005 May 19; 352(20):2111-9. PMID: 15901865.
        View in: PubMed
      23. Nesta F, Otsuji Y, Handschumacher MD, Messas E, Leavitt M, Carpentier A, Levine RA, Hung J. Leaflet concavity: a rapid visual clue to the presence and mechanism of functional mitral regurgitation. J Am Soc Echocardiogr. 2003 Dec; 16(12):1301-8. PMID: 14652610.
        View in: PubMed
      24. Freed LA, Acierno JS, Dai D, Leyne M, Marshall JE, Nesta F, Levine RA, Slaugenhaupt SA. A locus for autosomal dominant mitral valve prolapse on chromosome 11p15.4. Am J Hum Genet. 2003 Jun; 72(6):1551-9. PMID: 12707861; PMCID: PMC1180315.
      25. Mele D, Campana M, Sclavo M, Seveso G, Aschieri D, Nesta F, D'Aiello I, Ferrari R, Levine RA. Impact of tissue harmonic imaging in patients with distorted left ventricles: improvement in accuracy and reproducibility of visual, manual and automated echocardiographic assessment of left ventricular ejection fraction. Eur J Echocardiogr. 2003 Mar; 4(1):59-67. PMID: 12565064.
        View in: PubMed
      26. Mele D, Schwammenthal E, Torp H, Nesta F, Pedini I, Vandervoort P, Alboni P, Levine RA. A semiautomated objective technique for applying the proximal isovelocity surface area method to quantitate mitral regurgitation: Clinical studies with the digital flow map. Am Heart J. 2001 Apr; 141(4):653-60. PMID: 11275934.
        View in: PubMed
      27. Ferrari R, Pepi P, Ferrari F, Nesta F, Benigno M, Visioli O. Metabolic derangement in ischemic heart disease and its therapeutic control. Am J Cardiol. 1998 Sep 3; 82(5A):2K-13K. PMID: 9737480.
        View in: PubMed
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