As an epidemiologist and a general internal medicine physician, my research is designed to inform clinical decision-making and policy relevant to primary care and prevention. I focus on prevention of cardiovascular disease, and have particular interests in early life causes of atherosclerosis, primordial and primary coronary heart disease and stroke prevention, clinical decision-making regarding use of preventive medications (statins and anti-hypertensive medications) and screening for subclinical cardiovascular disease. I have special expertise in study design, decision and cost-effectiveness analysis, risk prediction, and evaluating the clinical utility of biomarkers, and I currently lead a data coordinating center for a major ongoing multicenter clinical trial, the Health eHeart Study (an online technology-enabled cardiovascular cohort study), and the Health eHeart Alliance, a PCORI-funded Patient-Powered Research Network focused on heart health. My primary appointment is in the Department of Epidemiology and Biostatistics at UCSF, and I see patients in General Internal Medicine at UCSF/Mt. Zion. I also help lead our nationally-recognized clinical research training programs, teach clinical research methods (Course Director for 2 classes), mentor students, fellows and junior faculty members, and direct the UCSF CTSI’s Informatics and Research Innovation Program.