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Julie Saba, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentPediatrics
Address
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    Collapse Research 
    Collapse Research Activities and Funding
    Agilent 6490 Triple Quadrupole Mass Spectrometer
    NIH S10OD018070Jun 1, 2014 - May 31, 2015
    Role: Principal Investigator
    IVIS Spectrum small animal imaging system
    NIH S10OD010335Jun 15, 2013 - Jun 14, 2014
    Role: Principal Investigator
    FASEB SRC on Lysophospholipd Mediators in Health and Disease
    NIH/NCI R13CA162835Aug 12, 2011 - Aug 11, 2012
    Role: Principal Investigator
    Soy sphingadienes and related compounds in colon cancer chemoprevention and treat
    NIH/NCCIH R21AT005336Sep 1, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Endogenous sphingosine-1-phosphate as a radioprotector of intestinal tissues
    NIH/NIAID RC1AI078516Sep 1, 2007 - Feb 28, 2011
    Role: Principal Investigator
    S1P Lyase in colon cancer
    NIH/NCI R01CA129438Jul 1, 2007 - Jan 31, 2018
    Role: Principal Investigator
    Sphingolipid Metabolism in Drosophila Development
    NIH/NIGMS R01GM066954Sep 1, 2003 - Feb 28, 2014
    Role: Principal Investigator
    Sphingosine Phosphate:Regulation and Role in Cancer
    NIH/NCI R01CA077528Sep 1, 1998 - Feb 28, 2011
    Role: Principal Investigator
    CERAMIDE MEDIATED SIGNAL TRANSDUCTION IN YEAST
    NIH/NCI K11CA059656Jul 1, 1993 - Jun 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Suh JH, Makarova AM, Gomez JM, Paul LA, Saba J. An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 01; 1061-1062:292-299. PMID: 28772225.
      View in: PubMed
    2. Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G. SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy. 2017 May 04; 13(5):885-899. PMID: 28521611.
      View in: PubMed
    3. Saba J, Logan AC. Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia. Clin Case Rep. 2017 Jun; 5(6):891-893. PMID: 28588833.
      View in: PubMed
    4. Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba J, Hildebrandt F. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017 Mar 01; 127(3):912-928. PMID: 28165339.
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    5. Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba JD. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. J Exp Med. 2016 Nov 14; 213(12):2773-2791. PMID: 27810923.
      View in: PubMed
    6. Suh JH, Saba JD. Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire. Transl Cancer Res. 2015 Oct 01; 4(5):469-483. PMID: 27011900.
      View in: PubMed
    7. Suh JH, Eltanawy A, Rangan A, Saba JD. A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity. Chem Phys Lipids. 2016 Jan; 194:101-9. PMID: 26408264; PMCID: PMC4718852 [Available on 01/01/17].
    8. Saba JD. A B cell-dependent mechanism restrains T cell transendothelial migration. Nat Med. 2015 May; 21(5):424-6. PMID: 25951526.
      View in: PubMed
    9. Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014 Dec; 124(12):5368-84. PMID: 25347472; PMCID: PMC4348973.
    10. Suh JH, Saba JD. Tracking hippo in the cancer jungle. Chem Biol. 2014 Jul 17; 21(7):803-4. PMID: 25036773.
      View in: PubMed
    11. Degagné E, Saba JD. S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. Clin Exp Gastroenterol. 2014; 7:205-14. PMID: 25061328; PMCID: PMC4085325.
    12. de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD. Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression. FASEB J. 2014 Jan; 28(1):506-19. PMID: 24158395; PMCID: PMC3868843.
    13. Smith GS, Kumar A, Saba JD. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules. 2013 Jun 24; 3(3):351-368. PMID: 24619572.
      View in: PubMed
    14. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol. 2013 Feb; 33(4):752-62. PMID: 23230267; PMCID: PMC3571353.
    15. Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res. 2012 Sep; 53(9):1920-31. PMID: 22781001; PMCID: PMC3413231.
    16. Saba JD, de la Garza-Rodea AS. S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. Biochim Biophys Acta. 2013 Jan; 1831(1):167-75. PMID: 22750505; PMCID: PMC3609719.
    17. Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochem Biophys Res Commun. 2012 Jul 20; 424(1):18-21. PMID: 22727907; PMCID: PMC3402648.
    18. Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst H, Zhang M, Proia RL, Hoffman EP, Saba JD. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS One. 2012; 7(5):e37218. PMID: 22606352; PMCID: PMC3351440.
    19. Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3ß pathway in colon cancer. Carcinogenesis. 2012 Sep; 33(9):1726-35. PMID: 22581840; PMCID: PMC3514901.
    20. Aguilar A, Saba JD. Truth and consequences of sphingosine-1-phosphate lyase. Adv Biol Regul. 2012 Jan; 52(1):17-30. PMID: 21946005; PMCID: PMC3560305.
    21. Loh KC, Baldwin D, Saba JD. Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. Anticancer Agents Med Chem. 2011 Nov; 11(9):782-93. PMID: 21707493; PMCID: PMC3259192.
    22. McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. PLoS One. 2011; 6(11):e26993. PMID: 22069480; PMCID: PMC3206050.
    23. Kumar A, Byun HS, Bittman R, Saba JD. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul; 23(7):1144-52. PMID: 21385609; PMCID: PMC3086202.
    24. Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol. 2011 May; 300(5):H1753-61. PMID: 21335477; PMCID: PMC3094087.
    25. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Cell Death Dis. 2011 Feb 10; 2:e119. PMID: 21368890; PMCID: PMC3101703.
    26. Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL. Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem. 2011 Mar 04; 286(9):7348-58. PMID: 21173151; PMCID: PMC3044991.
    27. Zhao Y, Gorshkova IA, Berdyshev E, He D, Fu P, Ma W, Su Y, Usatyuk PV, Pendyala S, Oskouian B, Saba JD, Garcia JG, Natarajan V. Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):426-35. PMID: 21148740; PMCID: PMC3175568.
    28. Fyrst H, Saba JD. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol. 2010 Jul; 6(7):489-97. PMID: 20559316; PMCID: PMC3001344.
    29. Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. Biochimie. 2010 Jun; 92(6):716-23. PMID: 20167244; PMCID: PMC2878883.
    30. Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res. 2010 Feb; 173(2):245-53. PMID: 20095857.
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    31. Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL. Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem. 2010 Apr 02; 285(14):10880-9. PMID: 20097939; PMCID: PMC2856294.
    32. Oskouian B, Saba JD. Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol. 2010; 688:185-205. PMID: 20919655; PMCID: PMC3076281.
    33. Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Res. 2009 Dec 15; 69(24):9457-64. PMID: 19934323; PMCID: PMC2795098.
    34. Serra M, Saba JD. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul. 2010; 50(1):349-62. PMID: 19914275; PMCID: PMC2862839.
    35. Francis-Goforth KN, Harken AH, Saba JD. Normalization of diabetic wound healing. Surgery. 2010 Mar; 147(3):446-9. PMID: 19703697; PMCID: PMC2827630.
    36. Kumar A, Saba JD. Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets. 2009 Aug; 13(8):1013-25. PMID: 19534571; PMCID: PMC2774446.
    37. Bandhuvula P, Li Z, Bittman R, Saba JD. Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):366-70. PMID: 19250638; PMCID: PMC2790368.
    38. Fyrst H, Saba JD. Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. Biochim Biophys Acta. 2008 Sep; 1781(9):448-58. PMID: 18558101; PMCID: PMC2749932.
    39. Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba JD. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. J Lipid Res. 2008 Mar; 49(3):597-606. PMID: 18156591.
      View in: PubMed
    40. Bandhuvula P, Fyrst H, Saba JD. A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity. J Lipid Res. 2007 Dec; 48(12):2769-78. PMID: 17872591.
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    41. Phan VH, Herr DR, Panton D, Fyrst H, Saba JD, Harris GL. Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. Dev Biol. 2007 Sep 15; 309(2):329-41. PMID: 17706961; PMCID: PMC2094363.
    42. Bandhuvula P, Saba JD. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. Trends Mol Med. 2007 May; 13(5):210-7. PMID: 17416206.
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    43. Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007 Feb 21; 26(4):1094-104. PMID: 17290222; PMCID: PMC1852826.
    44. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17384-9. PMID: 17090686; PMCID: PMC1859938.
    45. Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. 2006 Oct; 26(19):7211-23. PMID: 16980623; PMCID: PMC1592880.
    46. Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 2006 Mar; 54(3):742-53. PMID: 16508938.
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    47. Bandhuvula P, Tam YY, Oskouian B, Saba JD. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J Biol Chem. 2005 Oct 07; 280(40):33697-700. PMID: 16118221.
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    48. Oskouian B, Mendel J, Shocron E, Lee MA, Fyrst H, Saba JD. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors. J Biol Chem. 2005 May 06; 280(18):18403-10. PMID: 15734735.
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    49. Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17825-30. PMID: 15596715; PMCID: PMC535585.
    50. Oskouian B, Saba JD. Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. Semin Cell Dev Biol. 2004 Oct; 15(5):529-40. PMID: 15271298.
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    51. Saba JD. Lysophospholipids in development: Miles apart and edging in. J Cell Biochem. 2004 Aug 01; 92(5):967-92. PMID: 15258919.
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    52. Saba JD, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res. 2004 Apr 02; 94(6):724-34. PMID: 15059942.
      View in: PubMed
    53. Herr DR, Fyrst H, Creason MB, Phan VH, Saba JD, Harris GL. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. J Biol Chem. 2004 Mar 26; 279(13):12685-94. PMID: 14722126.
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    54. Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH, Saba JD. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004 Jan 09; 279(2):1281-90. PMID: 14570870.
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    55. Fyrst H, Herr DR, Harris GL, Saba JD. Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster. J Lipid Res. 2004 Jan; 45(1):54-62. PMID: 13130120.
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    56. Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba JD. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development. Development. 2003 Jun; 130(11):2443-53. PMID: 12702658.
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    57. Mendel J, Heinecke K, Fyrst H, Saba JD. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. J Biol Chem. 2003 Jun 20; 278(25):22341-9. PMID: 12682045.
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    58. Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH. Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease. Blood. 2003 Jan 01; 101(1):351-7. PMID: 12393579.
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    59. Birchwood CJ, Saba JD, Dickson RC, Cunningham KW. Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. J Biol Chem. 2001 Apr 13; 276(15):11712-8. PMID: 11278643.
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    60. Mao C, Saba JD, Obeid LM. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem J. 1999 Sep 15; 342 Pt 3:667-75. PMID: 10477278; PMCID: PMC1220508.
    61. Fyrst H, Oskouian B, Kuypers FA, Saba JD. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Biochemistry. 1999 May 04; 38(18):5864-71. PMID: 10231538.
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    62. Gottlieb D, Heideman W, Saba JD. The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. Mol Cell Biol Res Commun. 1999 Apr; 1(1):66-71. PMID: 10329480.
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    63. Oskouian B, Saba JD. YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae. Mol Gen Genet. 1999 Mar; 261(2):346-53. PMID: 10102370.
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    64. Lanterman MM, Saba JD. Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. Biochem J. 1998 Jun 01; 332 ( Pt 2):525-31. PMID: 9601083; PMCID: PMC1219509.
    65. Zhou J, Saba JD. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun. 1998 Jan 26; 242(3):502-7. PMID: 9464245.
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    66. Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem. 1997 Oct 17; 272(42):26087-90. PMID: 9334171.
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