Markus Delling, PhD

Title(s)Associate Professor, Physiology
SchoolSchool of Medicine
Address1550 Fourth St, #284E
San Francisco CA 94158
Phone415-476-2308
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    A comprehensive map of polycystin channel regulation and its implications in polycystic kidney disease
    NIH R01DK127277Sep 15, 2021 - Jul 31, 2025
    Role: Principal Investigator
    Polycystin activators as novel therapeutic approach for ADPKD
    NIH R21DK129906Jul 1, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Regulation and functional characterization of ciliary calcium signaling
    NIH R01GM130908Sep 1, 2019 - Aug 31, 2023
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function. bioRxiv. 2023 Dec 07. Ha K, Loeb GB, Park M, Pinedo A, Park CH, Brandes N, Ritu F, Ye CJ, Reiter JF, Delling M. PMID: 38106161; PMCID: PMC10723288.
      View in: PubMed   Mentions:
    2. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. Br J Pharmacol. 2023 Oct; 180 Suppl 2:S145-S222. Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Caceres AI, Catterall WA, Conner AC, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein SAN, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman AP, Jabba SV, Jarvis M, Jensen AA, Jordt SE, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch JW, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sieghart W, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, Zhu M. PMID: 38123150.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Testing the ion-current model for flagellar length sensing and IFT regulation. Elife. 2023 01 13; 12. Ishikawa H, Moore J, Diener DR, Delling M, Marshall WF. PMID: 36637158; PMCID: PMC9891718.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport. Curr Biol. 2022 09 26; 32(18):4071-4078.e4. Nievergelt AP, Zykov I, Diener D, Chhatre A, Buchholz TO, Delling M, Diez S, Jug F, Štepánek L, Pigino G. PMID: 35926510; PMCID: PMC9521741.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    5. Electrophysiological Recordings of the Polycystin Complex in the Primary Cilium of Cultured Mouse IMCD-3 Cell Line. Bio Protoc. 2021 Oct 20; 11(20):e4196. Ha K, Delling M. PMID: 34761068; PMCID: PMC8554804.
      View in: PubMed   Mentions:
    6. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S157-S245. Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. PMID: 34529831.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    7. The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus. Elife. 2020 11 09; 9. Ha K, Nobuhara M, Wang Q, Walker RV, Qian F, Schartner C, Cao E, Delling M. PMID: 33164752; PMCID: PMC7728438.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    8. New insights into ion channel-dependent signalling during left-right patterning. J Physiol. 2020 05; 598(9):1741-1752. Tajhya R, Delling M. PMID: 31106399.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. PMID: 29897330; PMCID: PMC6023609.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    10. MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 2016 06 30; 7:12109. Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. PMID: 27357649; PMCID: PMC4931332.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansAnimalsCells
    11. Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. PMID: 27007841; PMCID: PMC4851444.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    12. Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4. Doerner JF, Delling M, Clapham DE. PMID: 26650848; PMCID: PMC4714969.
      View in: PubMed   Mentions: 13     Fields:    
    13. Direct Recording and Molecular Identification of the Calcium Channel of Primary Cilia. Biophysical Journal. 2014 Jan 1; 106(2):638a. DeCaen DP, Delling DM, Clapham CD. .
      View in: Publisher Site   Mentions:
    14. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. PMID: 24336288; PMCID: PMC4112737.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimalsCells
    15. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. DeCaen PG, Delling M, Vien TN, Clapham DE. PMID: 24336289; PMCID: PMC4073646.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    16. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. PMID: 23542377; PMCID: PMC3631666.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    17. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. PMID: 22698280; PMCID: PMC3397829.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    18. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18114-9. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. PMID: 22025699; PMCID: PMC3207667.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    19. PI(3,5)P2 Controls Membrane Trafficking by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome. Biophysical Journal. 2011 Feb 1; 100(3):109a. Wang WX, Dong DX, Shen SD, Dawson DT, Li LX, Zhang ZQ, Cheng CX, Zhang ZY, Weisman WL, Delling DM, Xu XH. .
      View in: Publisher Site   Mentions:
    20. PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13; 1:38. Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PMID: 20802798; PMCID: PMC2928581.
      View in: PubMed   Mentions: 325     Fields:    Translation:AnimalsCells
    21. Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem. 2009 Nov 13; 284(46):32040-52. Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H. PMID: 19638346; PMCID: PMC2797275.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    22. The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endolysosomal Iron Release Channel. Biophysical Journal. 2009 Feb 1; 96(3):266a. Dong DX, Cheng CX, Mills ME, Delling DM, Wang WF, Kurz KT, Xu XH. .
      View in: Publisher Site   Mentions:
    23. Activation Mutations of the TRPML1 Channel Revealed by Proline Scanning Mutagenesis. Biophysical Journal. 2009 Feb 1; 96(3):266a. Wang WX, Dong DX, Chen CS, Shen SD, Liu LM, Mills ME, Cheng CX, Delling DM, Xu XH. .
      View in: Publisher Site   Mentions:
    24. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature. 2008 Oct 16; 455(7215):992-6. Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H. PMID: 18794901; PMCID: PMC4301259.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimalsCells
    25. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J Neurosci. 2008 Sep 03; 28(36):8897-907. Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. PMID: 18768683; PMCID: PMC4301590.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    26. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6. Xu H, Delling M, Li L, Dong X, Clapham DE. PMID: 17989217; PMCID: PMC2084341.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    27. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35. Xu H, Delling M, Jun JC, Clapham DE. PMID: 16617338.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimalsCells
    28. An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47. Ramsey IS, Delling M, Clapham DE. PMID: 16460286.
      View in: PubMed   Mentions: 659     Fields:    Translation:HumansAnimalsCells
    29. The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells. Membrane Microdomain Signaling. 2005 Jan 1; 113-125. Delling DM, Schachner SM. .
      View in: Publisher Site   Mentions:
    30. Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci. 2004 Oct 20; 24(42):9372-82. Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M. PMID: 15496673; PMCID: PMC6730092.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    31. Rapid and efficient electroporation-based gene transfer into primary dissociated neurons. J Neurosci Methods. 2003 Nov 30; 130(1):65-73. Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A. PMID: 14583405.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    32. The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. J Neurosci. 2002 Aug 15; 22(16):7154-64. Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M. PMID: 12177211; PMCID: PMC6757893.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    33. Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol. 2002 Apr 29; 157(3):521-32. Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M. PMID: 11980923; PMCID: PMC2173281.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    34. Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. J Neurobiol. 1999 Sep 05; 40(3):343-55. Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M. PMID: 10440734.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
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