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Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation. Nat Commun. 2024 Jul 31; 15(1):6468.
Ha K, Mundt-Machado N, Bisignano P, Pinedo A, Raleigh DR, Loeb G, Reiter JF, Cao E, Delling M. PMID: 39085216; PMCID: PMC11291729.
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Translation:
HumansAnimalsCells
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ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function. bioRxiv. 2023 Dec 07.
Ha K, Loeb GB, Park M, Pinedo A, Park CH, Brandes N, Ritu F, Ye CJ, Reiter JF, Delling M. PMID: 38106161; PMCID: PMC10723288.
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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. Br J Pharmacol. 2023 10; 180 Suppl 2:S145-S222.
Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Caceres AI, Catterall WA, Conner AC, Davies P, De Clerq K, Delling M, Di Virgilio F, Falzoni S, Fenske S, Fortuny-Gomez A, Fountain S, George C, Goldstein SAN, Grimm C, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Hu M, Ijzerman AP, Jabba SV, Jarvis M, Jensen AA, Jordt SE, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Liu Q, Lynch JW, Meades J, Mehlfeld V, Nicke A, Offermanns S, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sieghart W, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yang F, Fang W, Yue L, Zhang X, Zhu M. PMID: 38123150; PMCID: PMC11339754.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Testing the ion-current model for flagellar length sensing and IFT regulation. Elife. 2023 01 13; 12.
Ishikawa H, Moore J, Diener DR, Delling M, Marshall WF. PMID: 36637158; PMCID: PMC9891718.
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2 Fields:
Translation:
AnimalsCells
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Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport. Curr Biol. 2022 09 26; 32(18):4071-4078.e4.
Nievergelt AP, Zykov I, Diener D, Chhatre A, Buchholz TO, Delling M, Diez S, Jug F, Štepánek L, Pigino G. PMID: 35926510; PMCID: PMC9521741.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Electrophysiological Recordings of the Polycystin Complex in the Primary Cilium of Cultured Mouse IMCD-3 Cell Line. Bio Protoc. 2021 Oct 20; 11(20):e4196.
Ha K, Delling M. PMID: 34761068; PMCID: PMC8554804.
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S157-S245.
Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, Bill RM, Catterall WA, Conner AC, Davies P, Delling M, Virgilio FD, Falzoni S, Fenske S, George C, Goldstein SAN, Grissmer S, Ha K, Hammelmann V, Hanukoglu I, Jarvis M, Jensen AA, Kaczmarek LK, Kellenberger S, Kennedy C, King B, Kitchen P, Lynch JW, Perez-Reyes E, Plant LD, Rash L, Ren D, Salman MM, Sivilotti LG, Smart TG, Snutch TP, Tian J, Trimmer JS, Van den Eynde C, Vriens J, Wei AD, Winn BT, Wulff H, Xu H, Yue L, Zhang X, Zhu M. PMID: 34529831.
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PubMed Mentions:
78 Fields:
Translation:
Humans
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The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus. Elife. 2020 11 09; 9.
Ha K, Nobuhara M, Wang Q, Walker RV, Qian F, Schartner C, Cao E, Delling M. PMID: 33164752; PMCID: PMC7728438.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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New insights into ion channel-dependent signalling during left-right patterning. J Physiol. 2020 05; 598(9):1741-1752.
Tajhya R, Delling M. PMID: 31106399.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7.
McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. PMID: 29897330; PMCID: PMC6023609.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 2016 06 30; 7:12109.
Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. PMID: 27357649; PMCID: PMC4931332.
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PubMed Mentions:
260 Fields:
Translation:
HumansAnimalsCells
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Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60.
Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. PMID: 27007841; PMCID: PMC4851444.
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PubMed Mentions:
171 Fields:
Translation:
AnimalsCells
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Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4.
Doerner JF, Delling M, Clapham DE. PMID: 26650848; PMCID: PMC4714969.
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17 Fields:
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Direct Recording and Molecular Identification of the Calcium Channel of Primary Cilia. Biophysical Journal. 2014 Jan 1; 106(2):638a.
DeCaen DP, Delling DM, Clapham CD. .
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Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4.
Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. PMID: 24336288; PMCID: PMC4112737.
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PubMed Mentions:
283 Fields:
Translation:
HumansAnimalsCells
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Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8.
DeCaen PG, Delling M, Vien TN, Clapham DE. PMID: 24336289; PMCID: PMC4073646.
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PubMed Mentions:
177 Fields:
Translation:
HumansAnimalsCells
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Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9.
Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. PMID: 23542377; PMCID: PMC3631666.
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PubMed Mentions:
78 Fields:
Translation:
HumansCells
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Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62.
Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. PMID: 22698280; PMCID: PMC3397829.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18114-9.
Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. PMID: 22025699; PMCID: PMC3207667.
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PubMed Mentions:
113 Fields:
Translation:
HumansAnimalsCells
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PI(3,5)P2 Controls Membrane Trafficking by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome. Biophysical Journal. 2011 Feb 1; 100(3):109a.
Wang WX, Dong DX, Shen SD, Dawson DT, Li LX, Zhang ZQ, Cheng CX, Zhang ZY, Weisman WL, Delling DM, Xu XH. .
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PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13; 1:38.
Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PMID: 20802798; PMCID: PMC2928581.
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PubMed Mentions:
337 Fields:
Translation:
AnimalsCells
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Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem. 2009 Nov 13; 284(46):32040-52.
Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H. PMID: 19638346; PMCID: PMC2797275.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endolysosomal Iron Release Channel. Biophysical Journal. 2009 Feb 1; 96(3):266a.
Dong DX, Cheng CX, Mills ME, Delling DM, Wang WF, Kurz KT, Xu XH. .
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Activation Mutations of the TRPML1 Channel Revealed by Proline Scanning Mutagenesis. Biophysical Journal. 2009 Feb 1; 96(3):266a.
Wang WX, Dong DX, Chen CS, Shen SD, Liu LM, Mills ME, Cheng CX, Delling DM, Xu XH. .
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The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature. 2008 Oct 16; 455(7215):992-6.
Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H. PMID: 18794901; PMCID: PMC4301259.
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PubMed Mentions:
288 Fields:
Translation:
HumansAnimalsCells
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Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J Neurosci. 2008 Sep 03; 28(36):8897-907.
Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. PMID: 18768683; PMCID: PMC4301590.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
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Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6.
Xu H, Delling M, Li L, Dong X, Clapham DE. PMID: 17989217; PMCID: PMC2084341.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35.
Xu H, Delling M, Jun JC, Clapham DE. PMID: 16617338.
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PubMed Mentions:
251 Fields:
Translation:
HumansAnimalsCells
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An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47.
Ramsey IS, Delling M, Clapham DE. PMID: 16460286.
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PubMed Mentions:
671 Fields:
Translation:
HumansAnimalsCells
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The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells. Membrane Microdomain Signaling. 2005 Jan 1; 113-125.
Delling DM, Schachner SM. .
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Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci. 2004 Oct 20; 24(42):9372-82.
Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M. PMID: 15496673; PMCID: PMC6730092.
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PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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Rapid and efficient electroporation-based gene transfer into primary dissociated neurons. J Neurosci Methods. 2003 Nov 30; 130(1):65-73.
Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A. PMID: 14583405.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol. 2002 Nov 25; 159(4):649-61.
Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M. PMID: 12438412; PMCID: PMC2173095.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. J Neurosci. 2002 Aug 15; 22(16):7154-64.
Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M. PMID: 12177211; PMCID: PMC6757893.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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What can we learn from explanted endovascular devices? Eur J Vasc Endovasc Surg. 2002 Aug; 24(2):117-22.
Riepe G, Heintz C, Kaiser E, Chakfé N, Morlock M, Delling M, Imig H. PMID: 12389232.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol. 2002 Apr 29; 157(3):521-32.
Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M. PMID: 11980923; PMCID: PMC2173281.
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PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. J Neurobiol. 1999 Sep 05; 40(3):343-55.
Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M. PMID: 10440734.
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PubMed Mentions:
32 Fields:
Translation:
AnimalsCells