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Markus Delling, PhD

Title(s)Assistant Professor, Physiology
SchoolSchool of Medicine
Phone415-476-2308
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation and functional characterization of ciliary calcium signaling
    NIH/NIGMS R01GM130908Sep 1, 2019 - Aug 31, 2023
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tajhya R, Delling M. New insights into ion channel-dependent signalling during left-right patterning. J Physiol. 2019 May 20. PMID: 31106399.
      View in: PubMed
    2. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 06 13; 7. PMID: 29897330.
      View in: PubMed
    3. Zhang X, Cheng X, Yu L, Yang J, Calvo R, Patnaik S, Hu X, Gao Q, Yang M, Lawas M, Delling M, Marugan J, Ferrer M, Xu H. MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun. 2016 06 30; 7:12109. PMID: 27357649.
      View in: PubMed
    4. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE. Primary cilia are not calcium-responsive mechanosensors. Nature. 2016 Mar 31; 531(7596):656-60. PMID: 27007841.
      View in: PubMed
    5. Doerner JF, Delling M, Clapham DE. Ion channels and calcium signaling in motile cilia. Elife. 2015 Dec 09; 4. PMID: 26650848.
      View in: PubMed
    6. Paul G. DeCaen, Markus Delling, David E. Clapham. Direct Recording and Molecular Identification of the Calcium Channel of Primary Cilia. Biophysical Journal. 2014 Jan 1; 106(2):638a.
      View in: Publisher Site
    7. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12; 504(7479):311-4. PMID: 24336288.
      View in: PubMed
    8. DeCaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. Nature. 2013 Dec 12; 504(7479):315-8. PMID: 24336289.
      View in: PubMed
    9. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6364-9. PMID: 23542377.
      View in: PubMed
    10. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. Dev Cell. 2012 Jun 12; 22(6):1149-62. PMID: 22698280.
      View in: PubMed
    11. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18114-9. PMID: 22025699.
      View in: PubMed
    12. Xiang Wang, Xianping Dong, Dongbiao Shen, Taylor Dawson, Xinran Li, Qi Zhang, Xiping Cheng, Yanling Zhang, Lois S. Weisman, Markus Delling, Haoxing Xu. PI(3,5)P2 Controls Membrane Trafficking by Direct Activation of Mucolipin Ca2+ Release Channels in the Endolysosome. Biophysical Journal. 2011 Feb 1; 100(3):109a.
      View in: Publisher Site
    13. Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H. PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13; 1:38. PMID: 20802798.
      View in: PubMed
    14. Dong XP, Wang X, Shen D, Chen S, Liu M, Wang Y, Mills E, Cheng X, Delling M, Xu H. Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem. 2009 Nov 13; 284(46):32040-52. PMID: 19638346.
      View in: PubMed
    15. Xiang Wang, Xianping Dong, Su Chen, Dongbiao Shen, Meiling Liu, Eric Mills, Xiping Cheng, Markus Delling, Haoxing Xu. Activation Mutations of the TRPML1 Channel Revealed by Proline Scanning Mutagenesis. Biophysical Journal. 2009 Feb 1; 96(3):266a.
      View in: Publisher Site
    16. Xian-Ping Dong, Xiping Cheng, Eric Mills, Markus Delling, Fudi Wang, Tino Kurz, Haoxing Xu. The Type IV Mucolipidosis-Associated Protein TRPML1 is an Endolysosomal Iron Release Channel. Biophysical Journal. 2009 Feb 1; 96(3):266a.
      View in: Publisher Site
    17. Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature. 2008 Oct 16; 455(7215):992-6. PMID: 18794901.
      View in: PubMed
    18. Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J Neurosci. 2008 Sep 03; 28(36):8897-907. PMID: 18768683.
      View in: PubMed
    19. Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18321-6. PMID: 17989217.
      View in: PubMed
    20. Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May; 9(5):628-35. PMID: 16617338.
      View in: PubMed
    21. Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol. 2006; 68:619-47. PMID: 16460286.
      View in: PubMed
    22. Markus Delling, Melitta Schachner. The Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells. Membrane Microdomain Signaling. 2005 Jan 1; 113-125.
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    23. Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M. Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci. 2004 Oct 20; 24(42):9372-82. PMID: 15496673.
      View in: PubMed
    24. Dityateva G, Hammond M, Thiel C, Ruonala MO, Delling M, Siebenkotten G, Nix M, Dityatev A. Rapid and efficient electroporation-based gene transfer into primary dissociated neurons. J Neurosci Methods. 2003 Nov 30; 130(1):65-73. PMID: 14583405.
      View in: PubMed
    25. Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M. Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol. 2002 Nov 25; 159(4):649-61. PMID: 12438412.
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    26. Delling M, Wischmeyer E, Dityatev A, Sytnyk V, Veh RW, Karschin A, Schachner M. The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. J Neurosci. 2002 Aug 15; 22(16):7154-64. PMID: 12177211.
      View in: PubMed
    27. Riepe G, Heintz C, Kaiser E, Chakfé N, Morlock M, Delling M, Imig H. What can we learn from explanted endovascular devices? Eur J Vasc Endovasc Surg. 2002 Aug; 24(2):117-22. PMID: 12389232.
      View in: PubMed
    28. Niethammer P, Delling M, Sytnyk V, Dityatev A, Fukami K, Schachner M. Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol. 2002 Apr 29; 157(3):521-32. PMID: 11980923.
      View in: PubMed
    29. Stork O, Welzl H, Wotjak CT, Hoyer D, Delling M, Cremer H, Schachner M. Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. J Neurobiol. 1999 Sep 05; 40(3):343-55. PMID: 10440734.
      View in: PubMed