Gabriel Loeb, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
AddressSan Francisco CA 94158
PronounsHe/Him/His
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS2005Biology
    CornellMD2015Medicine
    Cornell/Rockefeller/Sloan KetteringPhD2015Immunology
    Brigham and Women's Hospital/Harvard Medical SchoolResidency2018Internal Medicine
    UCSFFellowship2021Nephrology

    Collapse Overview 
    Collapse Overview
    Gabriel Loeb, MD, PhD is a physician-scientist whose research and patient-care focuses on genetic kidney diseases.

    The Loeb laboratory uses genetics to understand the mechanisms underlying common and rare forms of kidney disease. Our research focuses on two major areas: 1) using human common genetic variation to identify cellular and molecular drivers of chronic kidney disease and 2) identifying the molecular mediators of Autosomal Dominant Polycystic Kidney Disease. By integrating human genetics, novel kidney disease models, and genomics we are discovering essential regulators of kidney health to enable new therapies for people suffering from kidney disease.

    In the UCSF Nephrology Faculty Practice, Dr. Loeb specializes in the care of individuals with familial and genetic forms of kidney disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Identification of Polycystic Kidney Disease Mediators in Kidney Organoids
    Laboratory For Genomics Research Innovation Award Aug 1, 2024 - Aug 1, 2025
    Physician Scientist Scholars Program, UCSF School of Medicine Sep 1, 2021 - Sep 1, 2026

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function. bioRxiv. 2024 Dec 03. Ha K, Loeb GB, Park M, Gupta M, Akiyama Y, Argiris J, Pinedo A, Park CH, Brandes N, Ritu F, Ye CJ, Reiter JF, Delling M. PMID: 38106161; PMCID: PMC10723288.
      View in: PubMed   Mentions:
    2. Deconvolution of Human Urine across the Transcriptome and Metabolome. Clin Chem. 2024 Nov 04; 70(11):1344-1354. Vorperian SK, DeFelice BC, Buonomo JA, Chinchinian HJ, Gray IJ, Yan J, Mach KE, La V, Lee TJ, Liao JC, Lafayette R, Loeb GB, Bertozzi CR, Quake SR. PMID: 39383112; PMCID: PMC11927302.
      View in: PubMed   Mentions:    Fields:    
    3. Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function. Nat Genet. 2024 Oct; 56(10):2078-2092. Loeb GB, Kathail P, Shuai RW, Chung R, Grona RJ, Peddada S, Sevim V, Federman S, Mader K, Chu AY, Davitte J, Du J, Gupta AR, Ye CJ, Shafer S, Przybyla L, Rapiteanu R, Ioannidis NM, Reiter JF. PMID: 39256582.
      View in: PubMed   Mentions: 2     Fields:    
    4. Current genomic deep learning models display decreased performance in cell type-specific accessible regions. Genome Biol. 2024 Aug 01; 25(1):202. Kathail P, Shuai RW, Chung R, Ye CJ, Loeb GB, Ioannidis NM. PMID: 39090688; PMCID: PMC11293111.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation. Nat Commun. 2024 Jul 31; 15(1):6468. Ha K, Mundt-Machado N, Bisignano P, Pinedo A, Raleigh DR, Loeb G, Reiter JF, Cao E, Delling M. PMID: 39085216; PMCID: PMC11291729.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Current genomic deep learning models display decreased performance in cell type specific accessible regions. bioRxiv. 2024 Jul 10. Kathail P, Shuai RW, Chung R, Ye CJ, Loeb GB, Ioannidis NM. PMID: 39026761; PMCID: PMC11257480.
      View in: PubMed   Mentions:
    7. Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function. bioRxiv. 2024 Jun 22. Loeb GB, Kathail P, Shuai R, Chung R, Grona RJ, Peddada S, Sevim V, Federman S, Mader K, Chu A, Davitte J, Du J, Gupta AR, Ye CJ, Shafer S, Przybyla L, Rapiteanu R, Ioannidis N, Reiter JF. PMID: 38948875; PMCID: PMC11212968.
      View in: PubMed   Mentions:
    8. Multiomics characterization of cell type repertoires for urine liquid biopsies. bioRxiv. 2023 Oct 23. Vorperian SK, DeFelice BC, Buonomo JA, Chinchinian HJ, Gray IJ, Yan J, Mach KE, La V, Lee TJ, Liao JC, Lafayette R, Loeb GB, Bertozzi CR, Quake SR. PMID: 37961398; PMCID: PMC10634682.
      View in: PubMed   Mentions:
    9. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 05 13; 376(6594):eabl4896. Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kong W, Kumar ME, Kuo AH, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, Olivieri JE, Park M, Ravikumar N, Stanley G, Tan W, Tarashansky AJ, Vanheusden R, Wang P, Wang S, Xing G, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Leylek R, Liu S, Maltzman JS, Metzger RJ, Phansalkar R, Sasagawa K, Sinha R, Song H, Swarup A, Trimm E, Veizades S, Wang B, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Kuo CS, Nguyen P, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wu A, Wu SM, Wyss-Coray T. PMID: 35549404; PMCID: PMC9812260.
      View in: PubMed   Mentions: 313     Fields:    Translation:HumansCells
    10. The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types. Nat Immunol. 2018 10; 19(10):1137-1145. Hsin JP, Lu Y, Loeb GB, Leslie CS, Rudensky AY. PMID: 30224821; PMCID: PMC6158091.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    11. Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6967-72. Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC. PMID: 23572582; PMCID: PMC3637707.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    12. Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol Cell. 2012 Dec 14; 48(5):760-70. Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY. PMID: 23142080; PMCID: PMC3562697.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    13. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009 Jul 03; 284(27):18515-24. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. PMID: 19419954; PMCID: PMC2709372.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    14. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009 Jan 16; 30(1):80-91. Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. PMID: 19144316; PMCID: PMC2654249.
      View in: PubMed   Mentions: 421     Fields:    Translation:HumansAnimalsCells
    15. Genome-wide profiling of salt fractions maps physical properties of chromatin. Genome Res. 2009 Mar; 19(3):460-9. Henikoff S, Henikoff JG, Sakai A, Loeb GB, Ahmad K. PMID: 19088306; PMCID: PMC2661814.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    16. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5614-9. Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT. PMID: 18385371; PMCID: PMC2291142.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    17. Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report. PLoS Genet. 2008 Feb; 4(2):e34. Osokine I, Hsu R, Loeb GB, McManus MT. PMID: 18282110; PMCID: PMC2242815.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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