Gabriel Loeb, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address500 Parnassus Avenue
San Francisco CA 94117
Phone--
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    Collapse Education and Training
    Stanford UniversityBS2005Biology
    CornellMD2015Medicine
    Cornell/Rockefeller/Sloan KetteringPhD2015Immunology
    Brigham and Women's Hospital/Harvard Medical SchoolResident2018Internal Medicine

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    Collapse Overview
    Gabriel Loeb, MD, PhD is a physician-scientist investigating the mechanisms underlying kidney disease. His research focuses on two major areas: 1) using human common genetic variation to identify cellular and molecular drivers of chronic kidney disease and 2) identifying the molecular mediators of Autosomal Dominant Polycystic Kidney Disease. Findings from both projects demonstrate the central role of tubule epithelial cells in kidney disease pathogenesis. Gabriel’s research program integrates human genetics, novel kidney disease models, and single cell genomics to reveal essential regulators of tubule epithelial cell health and enable new therapies for people suffering from kidney disease.

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    Collapse Research Activities and Funding
    UCSF School of Medicine Physician Scientist Scholars ProgramSep 1, 2021 - Sep 1, 2026

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 05 13; 376(6594):eabl4896. Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Pisco AO, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Crasta S, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kolluru S, Kong W, Kumar ME, Kuo AH, Leylek R, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Morri M, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Phansalkar R, Pisco AO, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Travaglini KJ, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Tan SY, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Detweiler AM, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, de Morree A, Olivieri JE, Park M, Pisco AO, Ravikumar N, Salzman J, Stanley G, Swift M, Tan M, Tan W, Tarashansky AJ, Vanheusden R, Vorperian SK, Wang P, Wang S, Xing G, Xu C, Yosef N, Alcántara-Hernández M, Antony J, Chan CKF, Chang CA, Colville A, Crasta S, Culver R, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Kershner AM, Kong W, Kumar ME, Kuo AH, Leylek R, Liu S, Loeb GB, Lu WJ, Maltzman JS, Metzger RJ, de Morree A, Neuhöfer P, Perez K, Phansalkar R, Qi Z, Rao P, Raquer-McKay H, Sasagawa K, Scott B, Sinha R, Song H, Spencer SP, Swarup A, Swift M, Travaglini KJ, Trimm E, Veizades S, Vijayakumar S, Wang B, Wang W, Winkler J, Xie J, Yung AR, Artandi SE, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Krasnow M, Kuo CS, Nguyen P, Quake SR, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wang B, Wu A, Wu SM, Wyss-Coray T. PMID: 35549404.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    2. The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types. Nat Immunol. 2018 10; 19(10):1137-1145. Hsin JP, Lu Y, Loeb GB, Leslie CS, Rudensky AY. PMID: 30224821; PMCID: PMC6158091.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    3. Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6967-72. Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC. PMID: 23572582; PMCID: PMC3637707.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    4. Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Mol Cell. 2012 Dec 14; 48(5):760-70. Loeb GB, Khan AA, Canner D, Hiatt JB, Shendure J, Darnell RB, Leslie CS, Rudensky AY. PMID: 23142080; PMCID: PMC3562697.
      View in: PubMed   Mentions: 199     Fields:    Translation:HumansAnimalsCells
    5. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009 Jul 03; 284(27):18515-24. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. PMID: 19419954; PMCID: PMC2709372.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    6. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009 Jan 16; 30(1):80-91. Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. PMID: 19144316; PMCID: PMC2654249.
      View in: PubMed   Mentions: 396     Fields:    Translation:HumansAnimalsCells
    7. Genome-wide profiling of salt fractions maps physical properties of chromatin. Genome Res. 2009 Mar; 19(3):460-9. Henikoff S, Henikoff JG, Sakai A, Loeb GB, Ahmad K. PMID: 19088306; PMCID: PMC2661814.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    8. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5614-9. Cuellar TL, Davis TH, Nelson PT, Loeb GB, Harfe BD, Ullian E, McManus MT. PMID: 18385371; PMCID: PMC2291142.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    9. Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report. PLoS Genet. 2008 Feb; 4(2):e34. Osokine I, Hsu R, Loeb GB, McManus MT. PMID: 18282110; PMCID: PMC2242815.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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