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Pamela Den Besten, DDS

TitleProfessor
SchoolUCSF School of Dentistry
DepartmentOrofacial Sciences
Address707 Parnassus Ave, Dentistry
San Francisco CA 94143
Phone415-502-6383
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    Collapse Research 
    Collapse Research Activities and Funding
    WDR72 in Tooth Enamel Formation
    NIH R21DE023411Mar 1, 2014 - Feb 29, 2016
    Role: Principal Investigator
    Effects of Fluoride on Behavior in Genetically Diverse Mouse Models
    NIH R21ES017813Feb 1, 2010 - Jan 31, 2013
    Role: Principal Investigator
    Genetic Variations Related to Fluorosis Susceptibility
    NIH R21DE018633Feb 19, 2008 - Jan 31, 2011
    Role: Principal Investigator
    Ameloblast Differentiation In Vitro: A Step Closer to Enamel Engineering
    NIH R21DE017910Aug 2, 2007 - Jul 31, 2009
    Role: Principal Investigator
    Enamel Fluorosis: Mechanisms of Action
    NIH R01DE013508Dec 1, 1999 - Aug 31, 2014
    Role: Principal Investigator
    Enamel Fluorosis: Mechanisms of Action
    NIH R56DE013508Dec 1, 1999 - Aug 31, 2011
    Role: Principal Investigator
    NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    NIH/NIDCR P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    Comprehensive Oral Health Training Program
    NIH/NIDCR T32DE007306Aug 1, 1996 - Jun 30, 2018
    Role: Principal Investigator
    FLUORIDE EFFECTS ON AMELOBLAST LIKE CELLS IN CULTURE
    NIH R03DE011733Apr 1, 1996 - Mar 31, 1999
    Role: Principal Investigator
    AMELOGENIN PROCESSING BY SERINE PROTEINASE(S) IN ENAMEL
    NIH R01DE010614Feb 1, 1994 - Jan 31, 1999
    Role: Principal Investigator
    EXPRESSION OF AMELOGENIN IN RNA DURING ENAMEL FORMATION
    NIH R03DE010546Sep 30, 1992 - Sep 29, 1995
    Role: Principal Investigator
    Characterization and Modification of Dental Hard Tissues
    NIH/NIDCR P01DE009859Aug 1, 1991 - Jun 30, 2008
    Role: Co-Investigator
    ALTERATIONS IN AMELOBLAST FUNCTION IN ENAMEL FLUOROSIS
    NIH R01DE009389Sep 1, 1990 - Aug 31, 1994
    Role: Principal Investigator
    EFFECTS OF PRENATAL FLUORIDE EXPOSURE ON FETAL RAT BONE
    NIH R03DE009642Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    PROTEINASES IN DEVELOPING ENAMEL MATRIX
    NIH R01DE008706Dec 1, 1988 - Nov 30, 1991
    Role: Principal Investigator
    EFFECTS OF CHRONIC HIGH FLUORIDE ON ENAMEL DEVELOPMENT
    NIH R29DE007384Sep 1, 1985 - Aug 31, 1990
    Role: Principal Investigator
    EFFECTS OF CHRONIC HIGH FLUORIDE ON ENAMEL DEVELOPMENT
    NIH R23DE007384Sep 1, 1985 - Aug 31, 1988
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nakano Y, Le MH, Abduweli D, Ho SP, Ryazanova LV, Hu Z, Ryazanov AG, Den Besten PK, Zhang Y. A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues. Front Physiol. 2016; 7:258. PMID: 27458382.
      View in: PubMed
    2. Le MH, Warotayanont R, Stahl J, Den Besten P, Nakano Y. Amelogenin Exon4 Forms a Novel miRNA That Directs Ameloblast and Osteoblast Differentiation. J Dent Res. 2016 Apr; 95(4):423-9. PMID: 26715056.
      View in: PubMed
    3. Stahl J, Nakano Y, Horst J, Zhu L, Le M, Zhang Y, Liu H, Li W, Den Besten PK. Exon4 amelogenin transcripts in enamel biomineralization. J Dent Res. 2015 Jun; 94(6):836-42. PMID: 25792521; PMCID: PMC4485327 [Available on 06/01/16].
    4. Zhang Y, Kim JY, Horst O, Nakano Y, Zhu L, Radlanski RJ, Ho S, Den Besten PK. Fluorosed mouse ameloblasts have increased SATB1 retention and Gaq activity. PLoS One. 2014; 9(8):e103994. PMID: 25090413; PMCID: PMC4121220.
    5. Rice JR, Boyd WA, Chandra D, Smith MV, Den Besten PK, Freedman JH. Comparison of the toxicity of fluoridation compounds in the nematode Caenorhabditis elegans. Environ Toxicol Chem. 2014 Jan; 33(1):82-8. PMID: 24105802.
      View in: PubMed
    6. Zhan L, Tan S, Den Besten P, Featherstone JD, Hoover CI. Factors related to maternal transmission of mutans streptococci in high-risk children-pilot study. Pediatr Dent. 2012 Jul-Aug; 34(4):e86-91. PMID: 23014079.
      View in: PubMed
    7. DenBesten PK, Zhu L, Li W, Tanimoto K, Liu H, Witkowska HE. Fluoride incorporation into apatite crystals delays amelogenin hydrolysis. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:3-7. PMID: 22243219; PMCID: PMC3433805.
    8. Zhang Y, Kim SO, Opsahl-Vital S, Ho SP, Souron JB, Kim C, Giles K, Den Besten PK. Multiple effects of the cellular prion protein on tooth development. Int J Dev Biol. 2011; 55(10-12):953-60. PMID: 22252492.
      View in: PubMed
    9. Boyce WT, Den Besten PK, Stamperdahl J, Zhan L, Jiang Y, Adler NE, Featherstone JD. Social inequalities in childhood dental caries: the convergent roles of stress, bacteria and disadvantage. Soc Sci Med. 2010 Nov; 71(9):1644-52. PMID: 20870333; PMCID: PMC2954891.
    10. Coppe C, Zhang Y, Den Besten PK. Characterization of primary dental pulp cells in vitro. Pediatr Dent. 2009 Nov-Dec; 31(7):467-71. PMID: 20108736.
      View in: PubMed
    11. Shiboski CH, Kawada P, Golinveaux M, Tornabene A, Krishnan S, Mathias R, Den Besten P, Rosenthal P. Oral disease burden and utilization of dental care patterns among pediatric solid organ transplant recipients. J Public Health Dent. 2009; 69(1):48-55. PMID: 18662252; PMCID: PMC3310210.
    12. Zhan L, Featherstone JD, Gansky SA, Hoover CI, Fujino T, Berkowitz RJ, Den Besten PK. Antibacterial treatment needed for severe early childhood caries. J Public Health Dent. 2006; 66(3):174-9. PMID: 16913243.
      View in: PubMed
    13. Featherstone JD, Adair SM, Anderson MH, Berkowitz RJ, Bird WF, Crall JJ, Den Besten PK, Donly KJ, Glassman P, Milgrom P, Roth JR, Snow R, Stewart RE. Caries management by risk assessment: consensus statement, April 2002. J Calif Dent Assoc. 2003 Mar; 31(3):257-69. PMID: 12693825.
      View in: PubMed
    14. Den Besten PK. Mechanism and timing of fluoride effects on developing enamel. J Public Health Dent. 1999; 59(4):247-51. PMID: 10682331.
      View in: PubMed
    15. Den Besten PK, Punzi JS, Li W. Purification and sequencing of a 21 kDa and 25 kDa bovine enamel metalloproteinase. Eur J Oral Sci. 1998 Jan; 106 Suppl 1:345-9. PMID: 9541246.
      View in: PubMed
    16. Den Besten PK, Mathews CH, Gao C, Li W. Primary culture and characterization of enamel organ epithelial cells. Connect Tissue Res. 1998; 38(1-4):3-8; discussion 35-41. PMID: 11063011.
      View in: PubMed
    17. Den Besten P, Giambro N. Treatment of fluorosed and white-spot human enamel with calcium sucrose phosphate in vitro. Pediatr Dent. 1995 Sep-Oct; 17(5):340-5. PMID: 8524682.
      View in: PubMed
    18. Giambro NJ, Prostak K, Den Besten PK. Characterization of fluorosed human enamel by color reflectance, ultrastructure, and elemental composition. Caries Res. 1995; 29(4):251-7. PMID: 7656293.
      View in: PubMed
    19. Den Besten PK. Dental fluorosis: its use as a biomarker. Adv Dent Res. 1994 Jun; 8(1):105-10. PMID: 7993553.
      View in: PubMed
    20. Den Besten PK. Effects of fluoride on protein secretion and removal during enamel development in the rat. J Dent Res. 1986 Oct; 65(10):1272-7. PMID: 3463596.
      View in: PubMed
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