Arun Rangaswami, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address550 16th Street, #001
San Francisco CA 94158
PronounsHe/Him/His
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    Collapse education and training
    Johns Hopkins University, Baltimore, MDBSc,B.BME05/1986Biology, Biomedical Engineering
    Washington University, St.Louis, St.Louis, MOMD05/1990Medicine
    St.Louis Children's Hospital, St.Louis, MON/A07/1993Internship & Residency, Pediatrics
    Stanford University, Palo Alto, CAN/A09/1996Fellowship, Pediatric Hematology-Oncology

    Collapse Overview 
    Collapse overview
    I am one of the senior solid tumor faculty at UCSF, having joined the institution in 2019. My scholarly and clinical practice have focused on the treatment of pediatric liver cancers and rare cancers. I was the US National PI for the International Hepatoblastoma therapeutic trials, SIOPEL 4 and SIOPEL 6.I am currently the senior sub-PI for the Hepatocellular Carcinoma treatment arm of the Pediatric Hepatic tumors International Therapeutic Trial (PHITT). I am also the Co-chair of the Children's Hepatic tumors International Collaboration (CHIC), the largest extant database for pediatric rare tumors.
    I facilitate an International Hepatobiliary Multicenter Tumor Board, where we consider therapeutic strategies for children with relapsed and refractory liver cancers from around the world, with expert participants from North America, Europe, and Asia.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pediatric Hepatocellular Carcinoma: A Review of Predisposing Conditions, Molecular Mechanisms, and Clinical Considerations. Int J Mol Sci. 2025 Jan 31; 26(3). Young EP, O'Neill AF, Rangaswami AA. PMID: 39941018; PMCID: PMC11818592.
      View in: PubMed   Mentions:    Fields:    
    2. Upfront or delayed surgery in resectable hepatoblastoma: analysis from the children's hepatic tumors international collaboration database. EClinicalMedicine. 2024 Oct; 76:102811. Hiyama E, Hishiki T, Yoshimura K, Krailo M, Maibach R, Haeberle B, Rangaswami A, Lopez-Terrada D, Malogolowkin MH, Ansari M, Alaggio R, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, Ranganathan S, Tanaka Y, Inoue T, Piao J, Lin J, Czauderna P, Meyers RL, Aronson DC. PMID: 39309724; PMCID: PMC11414700.
      View in: PubMed   Mentions:
    3. Subsequent Renal Cancer Among Childhood Cancer Survivors: Analysis of Surveillance, Epidemiology, and End Results. J Pediatr Hematol Oncol. 2024 08 01; 46(6):e387-e392. Bell A, Rangaswami A, Murphy P, Meng M, Raphael R, Wu N, Goldsby R. PMID: 38934569; PMCID: PMC11268548.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Consensus classification of pediatric hepatocellular tumors: A report from the Children's Hepatic tumors International Collaboration (CHIC). Pediatr Blood Cancer. 2023 Jun 29; e30505. Cho SJ, Ranganathan S, Alaggio R, Maibach R, Tanaka Y, Inoue T, Leuschner I, de Krijger R, Vokuhl C, Krailo M, Malogolowkin M, Meyers R, Czauderna P, Hiyama E, Ansari M, Morland B, Trobaugh-Lotrario A, O'Neill AF, Rangaswami A, Häberle B, López-Terrada D. PMID: 37384428.
      View in: PubMed   Mentions: 1     Fields:    
    5. Outcomes of Patients Treated for Hepatoblastoma with Low Alpha-Fetoprotein and/or Small Cell Undifferentiated Histology: A Report from the Children's Hepatic Tumors International Collaboration (CHIC). Cancers (Basel). 2023 Jan 11; 15(2). Trobaugh-Lotrario AD, Maibach R, Aronson DC, Rangaswami A, Häberle B, O'Neill AF, Schmid I, Ansari M, Hishiki T, Ranganathan S, Alaggio R, de Krijger RR, Tanaka Y, Cho SJ, Vokuhl C, Maxwell R, Krailo M, Hiyama E, Czauderna P, Finegold M, Feusner JH, Malogolowkin MH, Meyers RL, Lopez-Terrada D. PMID: 36672416; PMCID: PMC9857147.
      View in: PubMed   Mentions: 5  
    6. Type I and Ir pleuropulmonary blastoma (PPB): A report from the International PPB/DICER1 Registry. Cancer. 2023 02 15; 129(4):600-613. Nelson AT, Harris AK, Watson D, Miniati D, Finch M, Kamihara J, Mitchell SG, Wilson DB, Gettinger K, Rangaswami AA, Campos JM, Lederman S, Feltis BA, Vasta LM, Harney LA, Stewart DR, Dehner LP, Messinger YH, Hill DA, Schultz KAP. PMID: 36541021; PMCID: PMC10316522.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    7. Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/DICER1 Registry. J Clin Oncol. 2023 02 01; 41(4):778-789. Schultz KAP, Harris AK, Nelson AT, Watson D, Lucas JT, Miniati D, Stewart DR, Hagedorn KN, Mize W, Kamihara J, Mitchell SG, Wilson DB, Gettinger K, Rangaswami AA, Harney LA, Rodriguez Galindo C, Bisogno G, Dehner LP, Hill DA, Messinger YH. PMID: 36137255; PMCID: PMC9901992.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. Nat Commun. 2022 08 25; 13(1):4878. Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B. PMID: 36008377; PMCID: PMC9411569.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    9. Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults. J Hepatol. 2022 10; 77(4):1026-1037. Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH. PMID: 35577029; PMCID: PMC9524481.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    10. The Use of Fluorescence in situ Hybridization to Confirm PRKACA Gene Rearrangement in Fibrolamellar Hepatocellular Carcinoma: A Validation Study. Ann Clin Lab Sci. 2022 May; 52(3):475-483. Weiel JJ, Forgo B, Sage J, Rangaswami A, Hazard FK. PMID: 35777788.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Current Approaches in Hepatoblastoma-New Biological Insights to Inform Therapy. Curr Oncol Rep. 2022 09; 24(9):1209-1218. Wu PV, Rangaswami A. PMID: 35438389.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    12. Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature. Pediatr Blood Cancer. 2022 05; 69(5):e29499. Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E. PMID: 34939322; PMCID: PMC8957526.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. Mol Cancer Ther. 2021 10; 20(10):2016-2025. Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA. PMID: 34353895; PMCID: PMC9307079.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    14. Multimodality treatment including whole pleura radiation therapy for DICER1-associated pediatric pleuropulmonary blastoma. Pediatr Blood Cancer. 2021 06; 68(6):e29004. Hui C, Shin DH, Wakeling A, Donaldson SS, Hazard FK, Rangaswami A, Hiniker SM. PMID: 33751747.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group. J Med Genet. 2022 04; 59(4):318-327. Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U. PMID: 33622763.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    16. The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children's Hepatic tumors International Collaboration (CHIC) database. Pediatr Blood Cancer. 2020 08; 67(8):e28350. Haeberle B, Rangaswami A, Krailo M, Czauderna P, Hiyama E, Maibach R, Lopez-Terrada D, Aronson DC, Alaggio R, Ansari M, Malogolowkin MH, Perilongo G, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, Schmid I, von Schweinitz D, Ranganathan S, Yoshimura K, Hishiki T, Tanaka Y, Piao J, Feng Y, Rinaldi E, Saraceno D, Derosa M, Meyers RL. PMID: 32383794.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    17. QTc Prolongation and Risk of Torsades de Pointes in Hospitalized Pediatric Oncology Patients. J Pediatr. 2020 02; 217:33-38. Lim TR, Rangaswami AA, Dubin AM, Kapphahn KI, Sakarovitch C, Long J, Motonaga KS, Trela T, Ceresnak SR. PMID: 31761428.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor. Cold Spring Harb Mol Case Stud. 2019 10; 5(5). Sanders LM, Rangaswami A, Bjork I, Lam DL, Beale HC, Kephart ET, Durbin A, Learned K, Currie R, Lyle AG, Pfeil J, Shah AT, Lee AG, Leung SG, Behroozfard IH, Breese MR, Peralez J, Hazard FK, Lacayo N, Spunt SL, Haussler D, Salama SR, Sweet-Cordero EA, Vaske OM. PMID: 31645344; PMCID: PMC6824255.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer. JAMA Netw Open. 2019 10 02; 2(10):e1913968. Vaske OM, Bjork I, Salama SR, Beale H, Tayi Shah A, Sanders L, Pfeil J, Lam DL, Learned K, Durbin A, Kephart ET, Currie R, Newton Y, Swatloski T, McColl D, Vivian J, Zhu J, Lee AG, Leung SG, Spillinger A, Liu HY, Liang WS, Byron SA, Berens ME, Resnick AC, Lacayo N, Spunt SL, Rangaswami A, Huynh V, Torno L, Plant A, Kirov I, Zabokrtsky KB, Rassekh SR, Deyell RJ, Laskin J, Marra MA, Sender LS, Mueller S, Sweet-Cordero EA, Goldstein TC, Haussler D. PMID: 31651965; PMCID: PMC6822083.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    20. Orthotopic Liver Transplantation After Stereotactic Body Radiotherapy for Pediatric Hepatocellular Carcinoma with Central Biliary Obstruction and Nodal Involvement. Cureus. 2018 Oct 26; 10(10):e3499. Chen E, Rangaswami A, Esquivel CO, Concepcion W, Lungren M, Thakor AS, Yoo CH, Donaldson SS, Hiniker SM. PMID: 30648040; PMCID: PMC6318132.
      View in: PubMed   Mentions: 1  
    21. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. N Engl J Med. 2018 Jun 21; 378(25):2376-2385. Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall'Igna P, Hiyama E, Brichard B, Skeen J, Mateos ME, Capra M, Rangaswami AA, Ansari M, Rechnitzer C, Veal GJ, Covezzoli A, Brugières L, Perilongo G, Czauderna P, Morland B, Neuwelt EA. PMID: 29924955; PMCID: PMC6117111.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCTClinical Trials
    22. Transarterial chemoembolization in children to treat unresectable hepatocellular carcinoma. Pediatr Transplant. 2018 06; 22(4):e13187. Weiss KE, Sze DY, Rangaswami AA, Esquivel CO, Concepcion W, Lebowitz EA, Kothary N, Lungren MP. PMID: 29707868.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma. Ann Clin Lab Sci. 2017 Aug; 47(4):395-402. Cooney T, Wei MC, Rangaswami A, Xu L, Sage J, Hazard FK. PMID: 28801364.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration. Lancet Oncol. 2017 01; 18(1):122-131. Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P. PMID: 27884679; PMCID: PMC5650231.
      View in: PubMed   Mentions: 144     Fields:    Translation:Humans
    25. Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction. Pediatr Blood Cancer. 2017 06; 64(6). Hiniker SM, Rangaswami A, Lungren MP, Thakor AS, Concepcion W, Balazy KE, Kovalchuk N, Donaldson SS. PMID: 28436210.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Hepatoblastoma Arising in a Pigmented β-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature. Am J Surg Pathol. 2016 07; 40(7):998-1003. Louie CY, Concepcion W, Park JK, Rangaswami A, Finegold MJ, Hazard FK. PMID: 27096257.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model. Eur J Cancer. 2016 Jan; 52:92-101. Czauderna P, Haeberle B, Hiyama E, Rangaswami A, Krailo M, Maibach R, Rinaldi E, Feng Y, Aronson D, Malogolowkin M, Yoshimura K, Leuschner I, Lopez-Terrada D, Hishiki T, Perilongo G, von Schweinitz D, Schmid I, Watanabe K, Derosa M, Meyers R. PMID: 26655560; PMCID: PMC5141607.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    28. Synchronous Hepatoblastoma, Neuroblastoma, and Cutaneous Capillary Hemangiomas: A Case Report. Pediatr Dev Pathol. 2016 Jan-Feb; 19(1):74-9. Ozawa MG, Cooney T, Rangaswami A, Hazard FK. PMID: 26368548.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Genomic analysis of fibrolamellar hepatocellular carcinoma. Hum Mol Genet. 2015 Jan 01; 24(1):50-63. Xu L, Hazard FK, Zmoos AF, Jahchan N, Chaib H, Garfin PM, Rangaswami A, Snyder MP, Sage J. PMID: 25122662; PMCID: PMC4262492.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    30. Increased utilization of pediatric specialty care: a population study of pediatric oncology inpatients in California. J Pediatr Hematol Oncol. 2014 Mar; 36(2):99-107. Chamberlain LJ, Pineda N, Winestone L, Saynina O, Rangaswami A, Link M, Wise PH. PMID: 24517965.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    31. Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study. Lancet Oncol. 2013 Aug; 14(9):834-42. Zsiros J, Brugieres L, Brock P, Roebuck D, Maibach R, Zimmermann A, Childs M, Pariente D, Laithier V, Otte JB, Branchereau S, Aronson D, Rangaswami A, Ronghe M, Casanova M, Sullivan M, Morland B, Czauderna P, Perilongo G, International Childhood Liver Tumours Strategy Group (SIOPEL). PMID: 23831416; PMCID: PMC3730732.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
    32. Congenital pancreatoblastoma: report of an atypical case and review of the literature. J Pediatr Hematol Oncol. 2012 May; 34(4):310-5. Chisholm KM, Hsu CH, Kim MJ, Rangaswami A, Gray Hazard FK. PMID: 22278199.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: computer-assisted intravital microscopy study. J Investig Med. 2004 Sep; 52(6):402-6. Cheung AT, Chan MS, Ramanujam S, Rangaswami A, Curl K, Franklin P, Wun T. PMID: 15612454.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    34. Predictors of bacteremia in febrile children with sickle cell disease. J Pediatr Hematol Oncol. 2002 May; 24(4):279-83. West DC, Andrada E, Azari R, Rangaswami AA, Kuppermann N. PMID: 11972096.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease. Clin Lab Haematol. 2002 Apr; 24(2):81-8. Wun T, Cordoba M, Rangaswami A, Cheung AW, Paglieroni T. PMID: 11985552.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    36. Bcl-2 overexpression results in enhanced capacitative calcium entry and resistance to SKF-96365-induced apoptosis. Cancer Res. 2000 Aug 15; 60(16):4358-61. Williams SS, French JN, Gilbert M, Rangaswami AA, Walleczek J, Knox SJ. PMID: 10969777.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    37. Platelet activation in patients with sickle cell disease. Br J Haematol. 1998 Mar; 100(4):741-9. Wun T, Paglieroni T, Rangaswami A, Franklin PH, Welborn J, Cheung A, Tablin F. PMID: 9531343.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
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