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Elliot Stieglitz, MD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone415-502-2649
ORCID ORCID Icon0000-0001-7032-4623 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stony Brook MD2008School of Medicine
    New York Presbyterian - Weill Cornell2011Pediatric Residency
    University of California, San Francisco2014Pediatric Hematology Oncology Fellowship
    Collapse Awards and Honors
    V Foundation2019  - 2021Translational Research Award
    Pediatric Cancer Research Foundation2019  - 2020Research Award
    ASH/EHA2016  - 2016Translational Research Training in Hematology
    Alex's Lemonade Stand Foundation2015  - 2017Young Investigator Award
    American Cancer Society2016  - 2017Individual Research Award
    St. Baldrick's Foundation Fellowship2014  - 2016Fellow in Clinical Research

    Collapse Overview 
    Collapse Overview
    Juvenile myelomonocytic leukemia (JMML) is a blood cancer that affects young children and is often difficult to diagnose and treat. Currently available therapies cure only half of patients, with some children experiencing an aggressive disease course while a rare group get better with very little treatment. We have now shown that presence of secondary mutations via deep sequencing or droplet digital PCR predicts a poor outcome. We have most recently show that DNA methylation profiling can predict both good and poor responders at diagnosis.

    We are also running a clinical trial through the Children's Oncology Group for patients with relapsed and refractory JMML. This trial will test the safety and efficacy of the oral MEK inhibitor, trametinib. This trial is based on extensive pre-clinical testing and a strong genomic rationale. This trial marks an important step towards more effectively treating patients with Ras driven leukemia using targeted agents.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting SETBP1 in Myeloproliferative Disorders
    NIH/NHLBI K08HL135434Jan 1, 2017 - Dec 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Low toxicity and favorable overall survival in relapsed/refractory B-ALL following CAR T cells and CD34-selected T-cell depleted allogeneic hematopoietic cell transplant. Bone Marrow Transplant. 2020 May 10. Fabrizio VA, Kernan NA, Boulad F, Cancio M, Allen J, Higman M, Margossian SP, Mauguen A, Prockop S, Scaradavou A, Shah N, Spitzer B, Stieglitz E, Yeager N, O'Reilly RJ, Brentjens RJ, Jan Boelens J, Curran KJ. PMID: 32390002.
      View in: PubMed   Mentions:    Fields:    
    2. Precision cancer monitoring using a novel, fully integrated, microfluidic array partitioning digital PCR platform. Sci Rep. 2019 12 20; 9(1):19606. Dueck ME, Lin R, Zayac A, Gallagher S, Chao AK, Jiang L, Datwani SS, Hung P, Stieglitz E. PMID: 31862911.
      View in: PubMed   Mentions:    Fields:    
    3. The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2020 02; 67(2):e28079. Friend BD, Bailey-Olson M, Melton A, Shimano KA, Kharbanda S, Higham C, Winestone LE, Huang J, Stieglitz E, Dvorak CC. PMID: 31724815.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation. Blood. 2019 Nov 13; 134(Supplement_1):1693-1693. Julia Meyer, Maximillian Schönung, Christian Flotho, Adam B. Olshen, Mark Hartmann, Christoph Plass, Yusuke Okuno, Yoshiyuki Takahashi, Norihiro Murakami, Manabu Wakamatsu, Mignon L. Loh, Charlotte M. Niemeyer, Hideki Muramatsu, Daniel B. Lipka, Elliot Stieglitz. .
      View in: Publisher Site   Mentions:
    5. In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies. Blood. 2019 Nov 13; 134(Supplement_1):1337-1337. Matthew Nix, Yu-Hsiu T. Lin, Huimin Geng, Makeba Marcoulis, Paul Phojanakong, Donghui Wang, Veronica Steri, Jeffrey Whitman, Sagar Bapat, Elliot Stieglitz, Anne Deucher, Kristie L White, Byron C Hann, Arun P. Wiita. .
      View in: Publisher Site   Mentions:
    6. Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing. Leukemia. 2020 Feb; 34(2):662-666. Chao AK, Meyer JA, Lee AG, Hecht A, Tarver T, Van Ziffle J, Koegel AK, Golden C, Braun BS, Sweet-Cordero EA, Smith CC, Dvorak CC, Loh ML, Stieglitz E. PMID: 31511612.
      View in: PubMed   Mentions:    Fields:    
    7. Molecular assessment of pretransplant chemotherapy in the treatment of juvenile myelomonocytic leukemia. Pediatr Blood Cancer. 2019 11; 66(11):e27948. Hecht A, Meyer J, Chehab FF, White KL, Magruder K, Dvorak CC, Loh ML, Stieglitz E. PMID: 31347788.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children. Genes Chromosomes Cancer. 2019 10; 58(10):723-730. de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL. PMID: 31102422.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome. Am J Hum Genet. 2019 06 06; 104(6):1223-1232. Capri Y, Flex E, Krumbach OHF, Carpentieri G, Cecchetti S, Lißewski C, Rezaei Adariani S, Schanze D, Brinkmann J, Piard J, Pantaleoni F, Lepri FR, Goh ES, Chong K, Stieglitz E, Meyer J, Kuechler A, Bramswig NC, Sacharow S, Strullu M, Vial Y, Vignal C, Kensah G, Cuturilo G, Kazemein Jasemi NS, Dvorsky R, Monaghan KG, Vincent LM, Cavé H, Verloes A, Ahmadian MR, Tartaglia M, Zenker M. PMID: 31130282.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Genomic subtyping and therapeutic targeting of acute erythroleukemia. Nat Genet. 2019 04; 51(4):694-704. Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG. PMID: 30926971.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia. Blood. 2018 Nov 29; 132(Supplement 1):1405-1405. Andrew E. Place, Traci M. Blonquist, Elliot Stieglitz, Todd M Cooper, Lia Gore, Richard Aplenc, Mignon L. Loh, Melinda Pauly, Rachel E. Rau, Michael J. Burke, Julia Etchin, A. Thomas Look, Maria Luisa Sulis, Lewis B. Silverman. .
      View in: Publisher Site   Mentions:
    12. Germline GAB2 Mutations in Childhood Acute Lymphoblastic Leukemia. Blood. 2018 Nov 29; 132(Supplement 1):388-388. Adam J de Smith, Geneviève Lavoie, Kyle M Walsh, Sumeet Aujla, Erica Evans, Helen M Hansen, Ivan Smirnov, Alice Y Kang, Martin Zenker, John J Ceremsak, Elliot Stieglitz, Roberta McKean-Cowdin, Catherine Metayer, Philippe P Roux, Joseph L Wiemels. .
      View in: Publisher Site   Mentions:
    13. DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia: An International Collaborative Analysis and Development of a Common Diagnostic Platform. Blood. 2018 Nov 29; 132(Supplement 1):3093-3093. Maximilian Schoenung, Elliot Stieglitz, Hideki Muramatsu, Norihiro Murakami, Mark Hartmann, Manuel Wiesenfarth, Yusuke Okuno, Adam B. Olshen, Christoph Plass, Mignon L. Loh, Charlotte Niemeyer, Christian Flotho, Daniel B. Lipka. .
      View in: Publisher Site   Mentions:
    14. Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. 2019 03; 33(3):671-685. Kong G, You X, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J. PMID: 30206308.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. ABVD Without Radiation for Newly Diagnosed Pediatric and Young Adult Patients With Hodgkin Lymphoma: A Single Center Retrospective Analysis of 28 Consecutive Patients. J Pediatr Hematol Oncol. 2018 05; 40(4):290-294. Stieglitz E, Dinh T, Phelps AS, Pampaloni MH, Olshen AB, Robbins E. PMID: 29432308.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    16. Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study. Pediatr Blood Cancer. 2018 07; 65(7):e27034. Dvorak CC, Satwani P, Stieglitz E, Cairo MS, Dang H, Pei Q, Gao Y, Wall D, Mazor T, Olshen AB, Parker JS, Kahwash S, Hirsch B, Raimondi S, Patel N, Skeens M, Cooper T, Mehta PA, Grupp SA, Loh ML. PMID: 29528181.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    17. Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia. Nat Commun. 2017 12 19; 8(1):2127. Stieglitz E, Mazor T, Olshen AB, Geng H, Gelston LC, Akutagawa J, Lipka DB, Plass C, Flotho C, Chehab FF, Braun BS, Costello JF, Loh ML. PMID: 29259179.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    18. Dysregulation of the transcription factor runx1 in juvenile myelomonocytic leukemia. Experimental Hematology. 2017 Sep 1; 53:s51. Alan Cantor, Elisa Dorantes-Costa, Hui Huang, Sara Garcia, Elliot Stieglitz, Mignon Loh, Guo-Cheng Yuan. .
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    19. Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML. Blood. 2017 07 27; 130(4):397-407. Yoshimi A, Balasis ME, Vedder A, Feldman K, Ma Y, Zhang H, Lee SC, Letson C, Niyongere S, Lu SX, Ball M, Taylor J, Zhang Q, Zhao Y, Youssef S, Chung YR, Zhang XJ, Durham BH, Yang W, List AF, Loh ML, Klimek V, Berger MF, Stieglitz E, Padron E, Abdel-Wahab O. PMID: 28576879.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    20. International Interlaboratory Digital PCR Study Demonstrating High Reproducibility for the Measurement of a Rare Sequence Variant. Anal Chem. 2017 02 07; 89(3):1724-1733. Whale AS, Devonshire AS, Karlin-Neumann G, Regan J, Javier L, Cowen S, Fernandez-Gonzalez A, Jones GM, Redshaw N, Beck J, Berger AW, Combaret V, Dahl Kjersgaard N, Davis L, Fina F, Forshew T, Fredslund Andersen R, Galbiati S, González Hernández Á, Haynes CA, Janku F, Lacave R, Lee J, Mistry V, Pender A, Pradines A, Proudhon C, Saal LH, Stieglitz E, Ulrich B, Foy CA, Parkes H, Tzonev S, Huggett JF. PMID: 27935690.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    21. RUNX1 Is a Candidate Transcriptional Effector in Juvenile Myelomonocytic Leukemia. Blood. 2016 Dec 2; 128(22):2699-2699. Elisa Dorantes Acosta, Hui Huang, Sara P. Garcia, Elliot Stieglitz, Mignon L. Loh, G C Yuan, Alan B. Cantor. .
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    22. Comprehensive Inflammatory Cytokine Profiling Identifies IL-8/CXCL8 As Elevated, Associated with Proliferative Features, and Independently Prognostic in Chronic Myelomonocytic Leukemia (CMML). Blood. 2016 Dec 2; 128(22):109-109. Sandrine Niyongere, Nolwenn Lucas, Samir Sansil, Christopher L Cubitt, Maria E. Balasis, Jodi Kroeger, Qing Zhang, John J Ceremsak, Elliot Stieglitz, YuLong Zhao, Markus Ball, Rami S. Komrokji, Alan F List, Valeria Santini, Eric Solary, Eric Padron. .
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    23. The Genomic Landscape of Childhood and Adult Acute Erythroid Leukemia. Blood. 2016 Dec 2; 128(22):39-39. Ilaria Iacobucci, Ji Wen, Manja Meggendorfer, Catherine Carmichael, John K Choi, Katherine Masih, Yongjin Li, Debbie Payne, Daisuke Tomizawa, Nobutaka Kiyokawa, Laura J. Janke, Thomas B. Alexander, Stanley Pounds, Lei Shi, Marcus Valentine, Giuseppe Basso, Franco Locatelli, Shirley Kham Kow Yin, Allen Yeoh Eng Juh, Ries E Rhonda, Elliot Stieglitz, Andrew Wei, Ian D Lewis, Richard D'Andrea, Benjamin T. Kile, Jinghui Zhang, Mignon L. Loh, Soheil Meshinchi, Torsten Haferlach, Charles Mullighan. .
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    24. Germline RRAS2 mutations are not associated with Noonan syndrome. J Med Genet. 2016 Nov; 53(11):728. Ceremsak JJ, Yu A, Esquivel E, Lissewski C, Zenker M, Loh ML, Stieglitz E. PMID: 27055474.
      View in: PubMed   Mentions:    Fields:    
    25. Pediatric MDS: GATA screen the germline. Blood. 2016 Mar 17; 127(11):1377-8. Stieglitz E, Loh ML. PMID: 26989184.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet. 2016 Jan; 48(1):101. Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen SR, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber TA, Golub TR, Stegmaier K, Loh ML. PMID: 26711114.
      View in: PubMed   Mentions: 2     Fields:    
    27. Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Apr; 62(4):629-36. Stieglitz E, Ward AF, Gerbing RB, Alonzo TA, Arceci RJ, Liu YL, Emanuel PD, Widemann BC, Cheng JW, Jayaprakash N, Balis FM, Castleberry RP, Bunin NJ, Loh ML, Cooper TM. PMID: 25704135.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    28. Subclonal Mutations in SETBP1 Predict Relapse in Juvenile Myelomonocytic Leukemia. Blood. 2014 Dec 6; 124(21):410-410. Elliot Stieglitz, Camille B Troup, Laura C Gelston, Eric D Chow, Kristie B Yu, Jon Akutagawa, Amaro N Taylor-Weiner, Y. Lucy Liu, Peter D Emanuel, Benjamin S Braun, Robert B. Gerbing, Todd A. Alonzo, Mignon L. Loh. .
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    29. Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. Blood. 2015 Jan 15; 125(3):516-24. Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, Akutagawa J, Taylor-Weiner AN, Liu YL, Wang YD, Beckman K, Emanuel PD, Braun BS, Abate A, Gerbing RB, Alonzo TA, Loh ML. PMID: 25395418.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    30. Mutations in GATA2 are rare in juvenile myelomonocytic leukemia. Blood. 2014 Feb 27; 123(9):1426-7. Stieglitz E, Liu YL, Emanuel PD, Castleberry RP, Cooper TM, Shannon KM, Loh ML. PMID: 24578498.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    31. Pulmonary coccidiomycosis masquerading as refractory metastatic Ewing sarcoma. J Pediatr Hematol Oncol. 2014 Jan; 36(1):e57-60. Stieglitz E, Hsiang MS, Simko JP, Hirose S, Goldsby RE. PMID: 23588326.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    32. Mutations In GATA2 Are Rare In Juvenile Myelomonocytic Leukemia. Blood. 2013 Nov 15; 122(21):1526-1526. Elliot Stieglitz, Y. Lucy Liu, Peter D. Emanuel, Robert P. Castleberry, Todd Michael Cooper, Kevin Shannon, Mignon L. Loh. .
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    33. Genetic predispositions to childhood leukemia. Ther Adv Hematol. 2013 Aug; 4(4):270-90. Stieglitz E, Loh ML. PMID: 23926459.
      View in: PubMed   Mentions: