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Lena Winestone, MD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Phone415-476-2188
ORCID ORCID Icon0000-0001-9982-1594 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of PennsylvaniaBA2004Biochemistry
    Stanford University School of MedicineMD2009Medicine
    Lucile Packard Children's HospitalResidency2012Pediatrics
    Children's Hospital of PhiladelphiaFellowship2016Pediatric Hematology/Oncology
    Perelman School of Medicine, University of PennsylvaniaMSHP2016Health Policy Research
    Collapse Awards and Honors
    American Society of Hematology2016  - 2017Clinical Research Training Institute
    Bear Necessities Pediatric Cancer Foundation2016  - 2017Fellow Award
    Abramson Cancer Center2016  - 2018Paul Calabresi Career Development Award for Clinical Oncology (K12)
    Alex's Lemonade Stand Foundation 2016  - 2019Young Investigator Award
    American Society of Hematology2020  - 2022Fellow to Faculty Scholar Award

    Collapse Overview 
    Collapse Overview
    My research explores racial, ethnic, and socioeconomic disparities in access to care and outcome of leukemia and lymphoma treatment. I study access to care across the continuum of pediatric cancer from diagnosis and clinical trial enrollment through treatment and relapse to salvage therapies. My research has shown that African American children with acute lymphoblastic leukemia, acute myeloid leukemia, and mature B cell lymphoma are two times more likely to present with organ failure at the time of a new cancer diagnosis. My ongoing work investigates access to highly specialized and complex therapies such as stem cell transplant, chimeric antigen receptor T cells, and MIBG therapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Barriers to Care Questionnaire for Pediatric Patients with Leukemia
    American Society of Hematology Jul 1, 2020
    Role: Principal Investigator
    Work Flexibility and Financial Impact Among Families of Children with Cancer
    UCSF Clinical & Translational Science Institute Jun 15, 2020
    Role: Supervisor
    Access to MIBG Therapy for High Risk Neuroblastoma Patients
    American Cancer Society Feb 1, 2020
    Role: Principal Investigator
    In Depth Interviews regarding the Path to a Leukemia Diagnosis
    Alex's Lemonade Stand Foundation, Bear Necessities Pediatric Cancer Foundation Dec 1, 2018
    Role: Principal Investivator

    Collapse ORNG Applications 
    Collapse In The News
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Health Care Cost Associated With Contemporary Chronic Myelogenous Leukemia Therapy Compared With That of Other Hematologic Malignancies. JCO Oncol Pract. 2020 Aug 21; OP2000143. Wilkes JJ, Lyman GH, Doody DR, Chennupati S, Becker LK, Morin PE, Winestone LE, Henk HJ, Chow EJ. PMID: 32822255.
      View in: PubMed   Mentions:
    2. Comparison of total body irradiation versus non- total body irradiation containing regimens for de novo acute myeloid leukemia in children. Haematologica. 2020 Jun 18. Dandoy CE, Davies SM, Ahn KW, He Y, Kolb AE, Levine J, Bo-Subait S, Abdel-Azim H, Bhatt N, Chewing J, Gadalla S, Gloude N, Hayashi R, Lalefar NR, Law J, MacMillan M, O'Brien T, Prestidge T, Sharma A, Shaw P, Winestone L, Eapen M. PMID: 32554562.
      View in: PubMed   Mentions:    Fields:    
    3. Health plan expenditures young adults with newly-diagnosed Hodgkin lymphoma (HL) by care at NCI-designated comprehensive cancer centers (CCC) vs. other treatment sites (non-CCC). Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):7081-7081. Julie Anna Wolfson, Smita Bhatia, Jill P. Ginsberg, Laura Becker, David Bernstein, Henry J. Henk, Gary H. Lyman, Paul C. Nathan, Diane Puccetti, Jennifer J Wilkes, Lena Winestone, Kelly Kenzik. .
      View in: Publisher Site   Mentions:
    4. Identifying relapses and stem cell transplants in pediatric acute lymphoblastic leukemia using administrative data: Capturing national outcomes irrespective of trial enrollment. Pediatr Blood Cancer. 2020 May 11; e28315. Cahen VC, Li Y, Getz KD, Elgarten CW, DiNofia AM, Wilkes JJ, Winestone LE, Huang YV, Miller TP, Gramatges MM, Rabin KR, Fisher BT, Aplenc R, Seif AE. PMID: 32391940.
      View in: PubMed   Mentions:    Fields:    
    5. Insurance impacts survival for children, adolescents, and young adults with bone and soft tissue sarcomas. Cancer Med. 2020 02; 9(3):951-958. Penumarthy NL, Goldsby RE, Shiboski SC, Wustrack R, Murphy P, Winestone LE. PMID: 31838786.
      View in: PubMed   Mentions: 3     Fields:    
    6. The impact of total body irradiation-based regimens on outcomes in children and young adults with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2020 02; 67(2):e28079. Friend BD, Bailey-Olson M, Melton A, Shimano KA, Kharbanda S, Higham C, Winestone LE, Huang J, Stieglitz E, Dvorak CC. PMID: 31724815.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Area-Based Socioeconomic Disparities in Survival of Children with Newly Diagnosed Acute Myeloid Leukemia: A Report from the Children's Oncology Group. Blood. 2019 Nov 13; 134(Supplement_1):703-703. Lena E. Winestone, Kelly D Getz, Kira O Bona, Brian T. Fisher, Alan S Gamis, Alix E. Seif, Lillian Sung, Yi-Cheng Wang, Todd A. Alonzo, Richard Aplenc. .
      View in: Publisher Site   Mentions:
    8. Rates of Laboratory Adverse Events By Chemotherapy Course for Pediatric Acute Leukemia Patients within the Leukemia Electronic Abstraction of Records Network (LEARN). Blood. 2019 Nov 13; 134(Supplement_1):333-333. Tamara P. Miller, Kelly D Getz, Biniyam Demissei, Karen R. Rabin, Marla Daves, Philip J. Lupo, Michael E. Scheurer, Evanette Burrows, Brian T. Fisher, Robert W. Grundmeier, Judy Lee, Jennifer J. Wilkes, Lena E. Winestone, Maria Monica J. Gramatges, Richard Aplenc. .
      View in: Publisher Site   Mentions:
    9. 50 Years Ago in TheJournal ofPediatrics: Fifty-Two Forms of Childhood Cancer, United States Mortality Experience, 1960-1966. J Pediatr. 2019 10; 213:148. Winestone L, Cabana MD. PMID: 31561775.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Disparities in Survival and Health Outcomes in Childhood Leukemia. Curr Hematol Malig Rep. 2019 06; 14(3):179-186. Winestone LE, Aplenc R. PMID: 31073772.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Factors impacting time to diagnosis in pediatric, adolescent and young adult (AYA) patients with solid tumors. Journal of Clinical Oncology. 2019 May 20; 37(15_suppl):e21515-e21515. Elysia Marie Alvarez, Lena Winestone, Jeffrey McPheeters, Diane Puccetti, Jennifer Jill Wilkes, Henry J. Henk, Smita Bhatia, Jill P. Ginsberg, Theresa Keegan, Brad H. Pollock. .
      View in: Publisher Site   Mentions:
    12. Disparities in pediatric acute myeloid leukemia (AML) clinical trial enrollment. Leuk Lymphoma. 2019 09; 60(9):2190-2198. Winestone LE, Getz KD, Rao P, Li Y, Hall M, Huang YV, Seif AE, Fisher BT, Aplenc R. PMID: 30732497.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Hematopoietic Cell Transplantation in Young Adult Acute Lymphoblastic Leukemia: A United States Population-Level Analysis. J Adolesc Young Adult Oncol. 2019 06; 8(3):254-261. Muffly L, Li Q, Alvarez E, Kahn J, Winestone L, Cress R, Penn DC, Keegan THM. PMID: 30657424.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Comparable on-therapy mortality and supportive care requirements in Black and White patients following initial induction for pediatric acute myeloid leukemia. Pediatr Blood Cancer. 2019 04; 66(4):e27583. Li Y, Newton JG, Getz KD, Huang YS, Seif AE, Fisher BT, Aplenc R, Winestone LE. PMID: 30585685.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    15. Renal Complications Associated with HSCT. Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. 2018 Jan 1; 327-332. Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin. .
      View in: Publisher Site   Mentions:
    16. High human herpesvirus 6 viral load in pediatric allogeneic hematopoietic stem cell transplant patients is associated with detection in end organs and high mortality. Pediatr Transplant. 2018 03; 22(2). Winestone LE, Punn R, Tamaresis JS, Buckingham J, Pinsky BA, Waggoner JJ, Kharbanda S. PMID: 29181879.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Complications preceding early deaths in Black and White children with acute myeloid leukemia. Pediatr Blood Cancer. 2017 Dec; 64(12). Winestone LE, Getz KD, Miller TP, Li Y, Huang YS, Seif AE, Fisher BT, Aplenc R. PMID: 28727288.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report. Transfusion. 2017 06; 57(6):1401-1406. Prince SD, Winestone LE, Nance SJ, Friedman DF. PMID: 28369934.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. The role of acuity of illness at presentation in early mortality in black children with acute myeloid leukemia. Am J Hematol. 2017 Feb; 92(2):141-148. Winestone LE, Getz KD, Miller TP, Wilkes JJ, Sack L, Li Y, Huang YS, Seif AE, Bagatell R, Fisher BT, Epstein AJ, Aplenc R. PMID: 27862214.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Increased utilization of pediatric specialty care: a population study of pediatric oncology inpatients in California. J Pediatr Hematol Oncol. 2014 Mar; 36(2):99-107. Chamberlain LJ, Pineda N, Winestone L, Saynina O, Rangaswami A, Link M, Wise PH. PMID: 24517965.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Acceptability and feasibility of integration of HIV care services into antenatal clinics in rural Kenya: a qualitative provider interview study. Glob Public Health. 2012; 7(2):149-63. Winestone LE, Bukusi EA, Cohen CR, Kwaro D, Schmidt NC, Turan JM. PMID: 22043837.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    22. Immune reconstitution following autologous transfers of CD3/CD28 stimulated CD4(+) T cells to HIV-infected persons. Clin Immunol. 2004 Jun; 111(3):262-74. Bernstein WB, Cox JH, Aronson NE, Tracy L, Schlienger K, Ratto-Kim S, Garner R, Cotte J, Zheng Z, Winestone L, Liebig C, Galley LM, Connors M, Birx DL, Carroll RG, Levine BL. PMID: 15183147.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells