Kevin Shannon, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address1450 Third St, #236
San Francisco CA 94158
Phone415-476-5122
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    Collapse Biography 
    Collapse Education and Training
    Cornell University Medical College, New York, NYM.D.1979Medicine
    UT Southwestern, Dallas, TXResidency 1982Pediatrics
    UCSF , San Francisco, CAPost-Doc Fellow/Scholar1988Pediatric Hematology/Oncology
    Collapse Awards and Honors
    UCSF2000Roma & Marvin Auerback Distinguished Professor in Molecular Oncology
    National Cancer Institute2007  - 2017MERIT Award
    American Cancer Society2010  - 2020Research Professor Award
    Children’s Tumor Foundation2016Team Science Research Award
    Society of Memorial Sloan Kettering 2019Research Prize for Contributions to Pediatric Oncology
    UCSF2020UCSF Faculty Basic Science Lectureship

    Collapse Research 
    Collapse Research Activities and Funding
    Co-targeting Raf and MEK in Pediatric Acute Myeloid Leukemia
    Cookies for Kids Cancer Foundation Research GraantFeb 15, 2022 - Feb 14, 2024
    Role: Principal Investigator
    Developmental and HyperActive Ras Tumor SPORE
    NIH U54CA196519Sep 1, 2015 - Aug 31, 2026
    Role: Multiple Principal Investigator
    Selectively Targeting Oncogenic NRAS in Cancer
    NIH R01CA193994Apr 1, 2015 - Mar 31, 2026
    Role: Principal Investigtor
    Description: The goal of this project is to test the efficacy of targeting two nodes in the MAP kinase signaling pathway in RAS mutant AML with the MEK inhibitor Cobimetinib and the Raf inhibitor Belvarafenib.

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multidetector Computed Tomography Assessment of Anatomical Ventricular Tachycardia Isthmuses in Repaired Tetralogy of Fallot. JACC Clin Electrophysiol. 2024 Feb 27. Moore JP, Su J, Shannon KM, Perens GS, Newlon C, Bradfield JS, Shivkumar K. PMID: 38456860.
      View in: PubMed   Mentions:    Fields:    
    2. Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation. JCI Insight. 2023 09 08; 8(17). Chen PY, Huang BJ, Harris M, Boone C, Wang W, Carias H, Mesiona B, Mavrici D, Kohler AC, Bollag G, Zhang C, Zhang Y, Shannon K. PMID: 37681415; PMCID: PMC10544224.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Sinus rhythm QRS morphology reflects right ventricular activation and anatomical ventricular tachycardia isthmus conduction in repaired tetralogy of Fallot. Heart Rhythm. 2023 Dec; 20(12):1689-1696. Moore JP, Shannon KM, Khairy P, Waldmann V, Bessière F, Burrows A, Su J, Shivkumar K. PMID: 37598989.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Opposing effects of KDM6A and JDP2 on glucocorticoid sensitivity in T-ALL. Blood Adv. 2023 07 25; 7(14):3479-3484. Levinson AL, Tjoa K, Huang B, Meyer LK, Kim MO, Brady SW, Zhang J, Shannon K, Wandler AM. PMID: 36897249; PMCID: PMC10362263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Precision Oncology for Papillary Craniopharyngioma. N Engl J Med. 2023 Jul 13; 389(2):179-181. Blakeley JO, Shannon K. PMID: 37437149.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The CCDI Comes Out of the Starting Block. J Clin Oncol. 2023 Aug 20; 41(24):3973-3975. Shannon K. PMID: 37319399.
      View in: PubMed   Mentions:    Fields:    
    7. NFIA-ETO2, TP53, and erythroid leukemogenesis. Blood. 2023 05 04; 141(18):2168-2170. Huang BJ, Shannon K. PMID: 37140954.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Sidestepping SHP2 inhibition. J Exp Med. 2023 05 01; 220(5). Popescu B, Shannon K. PMID: 36880733; PMCID: PMC9997206.
      View in: PubMed   Mentions:    Fields:    
    9. MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus. Neuro Oncol. 2022 11 02; 24(11):1845-1856. de Blank PMK, Gross AM, Akshintala S, Blakeley JO, Bollag G, Cannon A, Dombi E, Fangusaro J, Gelb BD, Hargrave D, Kim A, Klesse LJ, Loh M, Martin S, Moertel C, Packer R, Payne JM, Rauen KA, Rios JJ, Robison N, Schorry EK, Shannon K, Stevenson DA, Stieglitz E, Ullrich NJ, Walsh KS, Weiss BD, Wolters PL, Yohay K, Yohe ME, Widemann BC, Fisher MJ. PMID: 35788692; PMCID: PMC9629420.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    10. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. PMID: 36002574; PMCID: PMC9433322.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    11. Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation. Bioorg Med Chem Lett. 2021 12 01; 53:128414. Suciu RM, Luvaga IK, Hazeen A, Weerasooriya C, Richardson SK, Firestone AJ, Shannon K, Howell AR, Cravatt BF. PMID: 34666187; PMCID: PMC8896339.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nat Chem Biol. 2021 08; 17(8):856-864. Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM, Henry CL, Richardson SK, Predovic M, Huang B, Dix MM, Howell AR, Niphakis MJ, Shannon K, Cravatt BF. PMID: 33927411; PMCID: PMC8900659.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    13. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21). Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. PMID: 32990679; PMCID: PMC7710308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    14. Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK. Mol Cancer Ther. 2020 11; 19(11):2382-2395. Pucciarelli D, Angus SP, Huang B, Zhang C, Nakaoka HJ, Krishnamurthi G, Bandyopadhyay S, Clapp DW, Shannon K, Johnson GL, Nakamura JL. PMID: 32847978; PMCID: PMC7907257.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Soil and Seed: Coconspirators in Therapy-Induced Myeloid Neoplasms. Blood Cancer Discov. 2020 07; 1(1):10-12. Shannon K, Link DC. PMID: 34661135; PMCID: PMC8500704.
      View in: PubMed   Mentions: 1     Fields:    
    16. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 05 14; 135(20):1772-1782. Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. PMID: 32219446; PMCID: PMC7225687.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 08; 34(8):2025-2037. Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K. PMID: 32066867; PMCID: PMC7440098.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    18. Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes. J Clin Invest. 2020 02 03; 130(2):863-876. Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML. PMID: 31687977; PMCID: PMC6994137.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    19. Subsequent Neoplasms After a Primary Tumor in Individuals With Neurofibromatosis Type 1. J Clin Oncol. 2019 11 10; 37(32):3050-3058. Bhatia S, Chen Y, Wong FL, Hageman L, Smith K, Korf B, Cannon A, Leidy DJ, Paz A, Andress JE, Friedman GK, Metrock K, Neglia JP, Arnold M, Turcotte LM, de Blank P, Leisenring W, Armstrong GT, Robison LL, Clapp DW, Shannon K, Nakamura JL, Fisher MJ. PMID: 31532722; PMCID: PMC6839906.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    20. CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition. PLoS One. 2019; 14(7):e0220026. Meyer LK, Delgado-Martin C, Maude SL, Shannon KM, Teachey DT, Hermiston ML. PMID: 31318944; PMCID: PMC6638974.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. PLoS Genet. 2019 06; 15(6):e1008168. Huang BJ, Wandler AM, Meyer LK, Dail M, Daemen A, Sampath D, Li Q, Wang X, Wong JC, Nakitandwe J, Downing JR, Zhang J, Taylor BS, Shannon K. PMID: 31199785; PMCID: PMC6594654.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019 04 09; 27(2):631-647.e5. Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP. PMID: 30970263; PMCID: PMC6690758.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer. Cancer Cell. 2018 11 12; 34(5):852-862.e4. Bielski CM, Donoghue MTA, Gadiya M, Hanrahan AJ, Won HH, Chang MT, Jonsson P, Penson AV, Gorelick A, Harris C, Schram AM, Syed A, Zehir A, Chapman PB, Hyman DM, Solit DB, Shannon K, Chandarlapaty S, Berger MF, Taylor BS. PMID: 30393068; PMCID: PMC6234065.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    24. Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes. JCI Insight. 2018 07 26; 3(14). Wong JC, Bryant V, Lamprecht T, Ma J, Walsh M, Schwartz J, Del Pilar Alzamora M, Mullighan CG, Loh ML, Ribeiro R, Downing JR, Carroll WL, Davis J, Gold S, Rogers PC, Israels S, Yanofsky R, Shannon K, Klco JM. PMID: 30046003; PMCID: PMC6124395.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    25. AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells. Cell Stem Cell. 2018 Jul 05; 23(1):86-100.e6. Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan AC, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT. PMID: 29910151; PMCID: PMC6035102.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    26. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. PLoS One. 2018; 13(5):e0193849. Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP. PMID: 29799846; PMCID: PMC5969748.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Mechanistic and Preclinical Insights from Mouse Models of Hematologic Cancer Characterized by Hyperactive Ras. Cold Spring Harb Perspect Med. 2018 04 02; 8(4). Wandler A, Shannon K. PMID: 28778967; PMCID: PMC5880163.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    28. A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies. Cancer Res. 2017 11 01; 77(21):5706-5711. Maertens O, McCurrach ME, Braun BS, De Raedt T, Epstein I, Huang TQ, Lauchle JO, Lee H, Wu J, Cripe TP, Clapp DW, Ratner N, Shannon K, Cichowski K. PMID: 28993414; PMCID: PMC5668167.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    29. KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. Cell. 2017 02 23; 168(5):817-829.e15. Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. PMID: 28215705; PMCID: PMC5541948.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    30. The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nat Med. 2017 Mar; 23(3):301-313. Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, Zhang Y, Perkins AS, Shannon K, Hemann MT, Puissant A, Stegmaier K. PMID: 28191887; PMCID: PMC5540325.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    31. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017 Apr 01; 23(7):1852-1861. Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. PMID: 27683180; PMCID: PMC5570538.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    32. Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency. Haematologica. 2016 10; 101(10):1190-1199. Sachs Z, Been RA, DeCoursin KJ, Nguyen HT, Mohd Hassan NA, Noble-Orcutt KE, Eckfeldt CE, Pomeroy EJ, Diaz-Flores E, Geurts JL, Diers MD, Hasz DE, Morgan KJ, MacMillan ML, Shannon KM, Largaespada DA, Wiesner SM. PMID: 27418650; PMCID: PMC5046648.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    33. KRAS insertion mutations are oncogenic and exhibit distinct functional properties. Nat Commun. 2016 Feb 08; 7:10647. White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, Carias H, Dickens D, Loh M, Shannon K, Firestone AJ. PMID: 26854029; PMCID: PMC4748120.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. KRAS Engages AGO2 to Enhance Cellular Transformation. Cell Rep. 2016 Feb 16; 14(6):1448-1461. Shankar S, Pitchiaya S, Malik R, Kothari V, Hosono Y, Yocum AK, Gundlapalli H, White Y, Firestone A, Cao X, Dhanasekaran SM, Stuckey JA, Bollag G, Shannon K, Walter NG, Kumar-Sinha C, Chinnaiyan AM. PMID: 26854235; PMCID: PMC4758864.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    35. Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife. 2015 Jul 20; 4. Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K. PMID: 26193121; PMCID: PMC4569895.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet. 2015 May; 47(5):539-43. Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. PMID: 25822087; PMCID: PMC4414804.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    37. CCR4 drives ATLL jail break. J Exp Med. 2014 Dec 15; 211(13):2485. Shannon KM. PMID: 25512583; PMCID: PMC4267231.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 2014 Dec 18; 124(26):3947-55. Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. PMID: 25361812; PMCID: PMC4271180.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    39. NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia. Blood. 2014 Nov 20; 124(22):3274-83. Sachs Z, LaRue RS, Nguyen HT, Sachs K, Noble KE, Mohd Hassan NA, Diaz-Flores E, Rathe SK, Sarver AL, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon KM, Largaespada DA. PMID: 25316678; PMCID: PMC4239336.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    40. Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia. Nature. 2014 Sep 25; 513(7519):512-6. Dail M, Wong J, Lawrence J, O'Connor D, Nakitandwe J, Chen SC, Xu J, Lee LB, Akagi K, Li Q, Aster JC, Pear WS, Downing JR, Sampath D, Shannon K. PMID: 25043004; PMCID: PMC4213126.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    41. A(nother) RAF mutation in LCH. Blood. 2014 May 15; 123(20):3063-5. Shannon K, Hermiston M. PMID: 24832939; PMCID: PMC4023415.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    42. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 2014 May 12; 25(5):652-65. Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW. PMID: 24794707; PMCID: PMC4206212.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    43. Mutations in GATA2 are rare in juvenile myelomonocytic leukemia. Blood. 2014 Feb 27; 123(9):1426-7. Stieglitz E, Liu YL, Emanuel PD, Castleberry RP, Cooper TM, Shannon KM, Loh ML. PMID: 24578498; PMCID: PMC3938154.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    44. Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke. BMC Cancer. 2014 Jan 05; 14:6. North M, Shuga J, Fromowitz M, Loguinov A, Shannon K, Zhang L, Smith MT, Vulpe CD. PMID: 24386979; PMCID: PMC3898384.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 03; 6(304):ra105. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PMID: 24300897; PMCID: PMC4117477.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    46. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature. 2013 Dec 05; 504(7478):143-147. Li Q, Bohin N, Wen T, Ng V, Magee J, Chen SC, Shannon K, Morrison SJ. PMID: 24284627; PMCID: PMC4128640.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    47. Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial. Clin Cancer Res. 2014 Jan 15; 20(2):490-8. Jain N, Curran E, Iyengar NM, Diaz-Flores E, Kunnavakkam R, Popplewell L, Kirschbaum MH, Karrison T, Erba HP, Green M, Poire X, Koval G, Shannon K, Reddy PL, Joseph L, Atallah EL, Dy P, Thomas SP, Smith SE, Doyle LA, Stadler WM, Larson RA, Stock W, Odenike O. PMID: 24178622; PMCID: PMC4310865.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCTClinical Trials
    48. Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood. 2013 Aug 29; 122(9):1610-20. Lu J, Zavorotinskaya T, Dai Y, Niu XH, Castillo J, Sim J, Yu J, Wang Y, Langowski JL, Holash J, Shannon K, Garcia PD. PMID: 23818547; PMCID: PMC3953014.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    49. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov. 2013 Sep; 3(9):993-1001. Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. PMID: 23733505; PMCID: PMC3770749.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    50. Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo. Blood. 2013 Jun 13; 121(24):4884-93. Shieh A, Ward AF, Donlan KL, Harding-Theobald ER, Xu J, Mullighan CG, Zhang C, Chen SC, Su X, Downing JR, Bollag GE, Shannon KM. PMID: 23637129; PMCID: PMC3682340.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    51. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. Sci Signal. 2013 Mar 26; 6(268):ra21. Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP. PMID: 23532335; PMCID: PMC3737252.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    52. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013 Jan; 123(1):335-9. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. PMID: 23221337; PMCID: PMC3533281.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    53. Targeting oncogenic Ras signaling in hematologic malignancies. Blood. 2012 Oct 25; 120(17):3397-406. Ward AF, Braun BS, Shannon KM. PMID: 22898602; PMCID: PMC3482854.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    54. Advancing the STATus of MPN pathogenesis. Blood. 2012 Apr 12; 119(15):3374-6. Shah NP, Shannon K. PMID: 22500049.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    55. Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood. 2012 Jan 26; 119(4):1032-5. Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K. PMID: 22144181; PMCID: PMC3271715.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    56. A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice. Sci Transl Med. 2011 Mar 30; 3(76):76ra27. Lyubynska N, Gorman MF, Lauchle JO, Hong WX, Akutagawa JK, Shannon K, Braun BS. PMID: 21451123; PMCID: PMC3265440.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    57. Oncogenic Ras scales the ALPS. Blood. 2011 Mar 10; 117(10):2747-8. Shannon K, Li Q. PMID: 21393497.
      View in: PubMed   Mentions: 1     Fields:    
    58. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood. 2011 Apr 21; 117(16):4253-61. Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS. PMID: 21398220; PMCID: PMC3087477.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    59. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. PMID: 21199799; PMCID: PMC3077533.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    60. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. PMID: 21163920; PMCID: PMC3056645.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    61. Genetics, epigenetics, and leukemia. N Engl J Med. 2010 Dec 16; 363(25):2460-1. Shannon K, Armstrong SA. PMID: 21067376; PMCID: PMC4117480.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    62. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med. 2010 Nov 22; 207(12):2581-94. Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, Le Beau MM, Kogan SC. PMID: 21059853; PMCID: PMC2989761.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    63. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev. 2010 Jul 01; 24(13):1389-402. Zhao Z, Zuber J, Diaz-Flores E, Lintault L, Kogan SC, Shannon K, Lowe SW. PMID: 20595231; PMCID: PMC2895198.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    64. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood. 2010 Jun 03; 115(22):4524-32. Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K. PMID: 20233966; PMCID: PMC2881500.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    65. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. PMID: 20194733; PMCID: PMC2841878.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    66. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. PMID: 20014119; PMCID: PMC4051786.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    67. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature. 2009 Sep 17; 461(7262):411-4. Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K. PMID: 19727076; PMCID: PMC4119783.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    68. Cancer: More than kin and less than kind. Nature. 2009 Aug 13; 460(7257):804-7. Shannon K, Loh M. PMID: 19675635.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    69. The SPS affair: a complex tale of illicit proliferation. Cancer Cell. 2009 Aug 04; 16(2):87-8. Braun BS, Shannon K. PMID: 19647218.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    70. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood. 2009 Aug 27; 114(9):1859-63. Loh ML, Sakai DS, Flotho C, Kang M, Fliegauf M, Archambeault S, Mullighan CG, Chen L, Bergstraesser E, Bueso-Ramos CE, Emanuel PD, Hasle H, Issa JP, van den Heuvel-Eibrink MM, Locatelli F, Stary J, Trebo M, Wlodarski M, Zecca M, Shannon KM, Niemeyer CM. PMID: 19571318; PMCID: PMC2738571.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    71. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009 Mar 17; 7(3):e59. Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS. PMID: 19296721; PMCID: PMC2656550.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    72. Tumor suppressor gene inactivation in myeloid malignancies. Best Pract Res Clin Haematol. 2008 Dec; 21(4):601-14. Wong JC, Le Beau MM, Shannon K. PMID: 19041599.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    73. A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene. Blood. 2009 Jan 29; 113(5):1075-85. Yin B, Delwel R, Valk PJ, Wallace MR, Loh ML, Shannon KM, Largaespada DA. PMID: 18948576; PMCID: PMC2635073.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    74. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008 Oct 07; 14(4):335-43. Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML. PMID: 18835035; PMCID: PMC2647559.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    75. MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood. 2009 Feb 12; 113(7):1455-63. Zhang Y, Wong J, Klinger M, Tran MT, Shannon KM, Killeen N. PMID: 18818388; PMCID: PMC2644073.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    76. Targeting Ras in myeloid leukemias. Clin Cancer Res. 2008 Apr 15; 14(8):2249-52. Braun BS, Shannon K. PMID: 18413813.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    77. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008 May; 40(5):600-8. Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. PMID: 18372904; PMCID: PMC2410301.
      View in: PubMed   Mentions: 326     Fields:    Translation:HumansAnimalsCells
    78. Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. Hum Mutat. 2008 Feb; 29(2):232-9. Denayer E, Parret A, Chmara M, Schubbert S, Vogels A, Devriendt K, Frijns JP, Rybin V, de Ravel TJ, Shannon K, Cools J, Scheffzek K, Legius E. PMID: 17979197.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    79. Cancer: hay in a haystack. Nature. 2008 Jan 17; 451(7176):252-3. Shannon KM, Le Beau MM. PMID: 18202630.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    80. Outcomes in CCG-2961, a children's oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children's oncology group. Blood. 2008 Feb 01; 111(3):1044-53. Lange BJ, Smith FO, Feusner J, Barnard DR, Dinndorf P, Feig S, Heerema NA, Arndt C, Arceci RJ, Seibel N, Weiman M, Dusenbery K, Shannon K, Luna-Fineman S, Gerbing RB, Alonzo TA. PMID: 18000167; PMCID: PMC2214754.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCTClinical Trials
    81. Biochemical and functional characterization of germ line KRAS mutations. Mol Cell Biol. 2007 Nov; 27(22):7765-70. Schubbert S, Bollag G, Lyubynska N, Nguyen H, Kratz CP, Zenker M, Niemeyer CM, Molven A, Shannon K. PMID: 17875937; PMCID: PMC2169154.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    82. Targeting oncogenic Ras. Genes Dev. 2007 Aug 15; 21(16):1989-92. Diaz-Flores E, Shannon K. PMID: 17699748.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    83. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer. 2007 Apr; 7(4):295-308. Schubbert S, Shannon K, Bollag G. PMID: 17384584.
      View in: PubMed   Mentions: 693     Fields:    Translation:HumansCells
    84. Abnormal hematopoiesis in Gab2 mutant mice. Blood. 2007 Jul 01; 110(1):116-24. Zhang Y, Diaz-Flores E, Li G, Wang Z, Kang Z, Haviernikova E, Rowe S, Qu CK, Tse W, Shannon KM, Bunting KD. PMID: 17374739; PMCID: PMC1896106.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    85. Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Curr Opin Genet Dev. 2007 Feb; 17(1):15-22. Schubbert S, Bollag G, Shannon K. PMID: 17208427.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    86. Sending out an SOS. Nat Genet. 2007 Jan; 39(1):8-9. Shannon K, Bollag G. PMID: 17192780.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    87. K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells. Blood. 2007 May 01; 109(9):3945-52. Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS. PMID: 17192389; PMCID: PMC1874575.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    88. Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders. Cell Cycle. 2006 Aug; 5(15):1607-11. Kratz CP, Schubbert S, Bollag G, Niemeyer CM, Shannon KM, Zenker M. PMID: 16921267.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    89. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 2006 Sep 15; 108(6):2041-4. Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. PMID: 16720837; PMCID: PMC1895533.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    90. Interstitial uniparental isodisomy at clustered breakpoint intervals is a frequent mechanism of NF1 inactivation in myeloid malignancies. Blood. 2006 Sep 01; 108(5):1684-9. Stephens K, Weaver M, Leppig KA, Maruyama K, Emanuel PD, Le Beau MM, Shannon KM. PMID: 16690971; PMCID: PMC1895516.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    91. Inherited predispositions and hyperactive Ras in myeloid leukemogenesis. Pediatr Blood Cancer. 2006 May 01; 46(5):579-85. Lauchle JO, Braun BS, Loh ML, Shannon K. PMID: 16261595.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    92. Harnessing preclinical mouse models to inform human clinical cancer trials. J Clin Invest. 2006 Apr; 116(4):847-52. Gutmann DH, Hunter-Schaedle K, Shannon KM. PMID: 16585951; PMCID: PMC1421367.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    93. Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01. Blood. 2006 Jun 01; 107(11):4508-13. Loh ML, Goldwasser MA, Silverman LB, Poon WM, Vattikuti S, Cardoso A, Neuberg DS, Shannon KM, Sallan SE, Gilliland DG. PMID: 16493009; PMCID: PMC1895800.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    94. Germline KRAS mutations cause Noonan syndrome. Nat Genet. 2006 Mar; 38(3):331-6. Schubbert S, Zenker M, Rowe SL, Böll S, Klein C, Bollag G, van der Burgt I, Musante L, Kalscheuer V, Wehner LE, Nguyen H, West B, Zhang KY, Sistermans E, Rauch A, Niemeyer CM, Shannon K, Kratz CP. PMID: 16474405.
      View in: PubMed   Mentions: 272     Fields:    Translation:Humans
    95. Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell. 2005 Oct; 8(4):337-48. Chao RC, Pyzel U, Fridlyand J, Kuo YM, Teel L, Haaga J, Borowsky A, Horvai A, Kogan SC, Bonifas J, Huey B, Jacks TE, Albertson DG, Shannon KM. PMID: 16226708.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    96. Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia. Blood. 2005 Aug 15; 106(4):1183-8. Arceci RJ, Sande J, Lange B, Shannon K, Franklin J, Hutchinson R, Vik TA, Flowers D, Aplenc R, Berger MS, Sherman ML, Smith FO, Bernstein I, Sievers EL. PMID: 15886328.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCTClinical Trials
    97. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. Genomics. 2005 May; 85(5):600-7. Curtiss NP, Bonifas JM, Lauchle JO, Balkman JD, Kratz CP, Emerling BM, Green ED, Le Beau MM, Shannon KM. PMID: 15820312.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    98. JAKing up hematopoietic proliferation. Cancer Cell. 2005 Apr; 7(4):291-3. Shannon K, Van Etten RA. PMID: 15837617.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    99. Granulocyte/macrophage colony-stimulating factor and accessory cells modulate radioprotection by purified hematopoietic cells. J Exp Med. 2005 Mar 21; 201(6):853-8. Katsumoto TR, Duda J, Kim A, Wardak Z, Dranoff G, Clapp DW, Shannon K. PMID: 15781578; PMCID: PMC2213101.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    100. Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood. 2005 Jul 01; 106(1):311-7. Schubbert S, Lieuw K, Rowe SL, Lee CM, Li X, Loh ML, Clapp DW, Shannon KM. PMID: 15761018; PMCID: PMC1895116.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    101. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell. 2004 Dec; 6(6):547-52. Van Etten RA, Shannon KM. PMID: 15607959.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    102. RAS, FLT3, and TP53 mutations in therapy-related myeloid malignancies with abnormalities of chromosomes 5 and 7. Genes Chromosomes Cancer. 2004 Mar; 39(3):217-23. Side LE, Curtiss NP, Teel K, Kratz C, Wang PW, Larson RA, Le Beau MM, Shannon KM. PMID: 14732923.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    103. The sum is greater than the FGFR1 partner. Cancer Cell. 2004 Mar; 5(3):203-4. Braun BS, Shannon K. PMID: 15050910.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    104. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004 Jun 01; 103(11):4243-50. Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM. PMID: 14982883.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    105. SHP-2 and myeloid malignancies. Curr Opin Hematol. 2004 Jan; 11(1):44-50. Tartaglia M, Niemeyer CM, Shannon KM, Loh ML. PMID: 14676626.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    106. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):597-602. Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. PMID: 14699048; PMCID: PMC327193.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    107. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood. 2004 Mar 15; 103(6):2325-31. Loh ML, Vattikuti S, Schubbert S, Reynolds MG, Carlson E, Lieuw KH, Cheng JW, Lee CM, Stokoe D, Bonifas JM, Curtiss NP, Gotlib J, Meshinchi S, Le Beau MM, Emanuel PD, Shannon KM. PMID: 14644997.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    108. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11630-5. Wong S, McLaughlin J, Cheng D, Shannon K, Robb L, Witte ON. PMID: 14500898; PMCID: PMC208809.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    109. Acute myeloid leukemia associated with t(8;21) or trisomy 8 in children with neurofibromatosis, type 1. J Pediatr Hematol Oncol. 2003 Apr; 25(4):343. Kratz CP, Antonietti L, Shannon KM, Dole MG, Friebert SE. PMID: 12679655.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    110. Mouse cancer models as a platform for performing preclinical therapeutic trials. Curr Opin Genet Dev. 2003 Feb; 13(1):84-9. Weiss B, Shannon K. PMID: 12573440.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    111. Testing of new agents in childhood cancer preclinical models: meeting summary. Clin Cancer Res. 2002 Dec; 8(12):3646-57. Houghton PJ, Adamson PC, Blaney S, Fine HA, Gorlick R, Haber M, Helman L, Hirschfeld S, Hollingshead MG, Israel MA, Lock RB, Maris JM, Merlino G, Patterson W, Reynolds CP, Shannon K, Yu A, Yu J, Smith MA. PMID: 12473573.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    112. Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells. Cancer Cell. 2002 Dec; 2(6):507-14. Donovan S, See W, Bonifas J, Stokoe D, Shannon KM. PMID: 12498719.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    113. Acute leukemia: a pediatric perspective. Cancer Cell. 2002 Dec; 2(6):437-45. Downing JR, Shannon KM. PMID: 12498712.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    114. Hematologic effects of inactivating the Ras processing enzyme Rce1. Blood. 2003 Mar 15; 101(6):2250-2. Aiyagari AL, Taylor BR, Aurora V, Young SG, Shannon KM. PMID: 12433685.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    115. Resistance in the land of molecular cancer therapeutics. Cancer Cell. 2002 Aug; 2(2):99-102. Shannon KM. PMID: 12204529.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    116. MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Oncogene. 2002 Jul 18; 21(31):4849-54. Emerling BM, Bonifas J, Kratz CP, Donovan S, Taylor BR, Green ED, Le Beau MM, Shannon KM. PMID: 12101424.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    117. Ras processing as a therapeutic target in hematologic malignancies. Curr Opin Hematol. 2002 Jul; 9(4):308-15. Le DT, Shannon KM. PMID: 12042705.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    118. GTPase activating proteins: critical regulators of intracellular signaling. Biochim Biophys Acta. 2002 Mar 14; 1602(1):23-45. Donovan S, Shannon KM, Bollag G. PMID: 11960693.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    119. Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor. Blood. 2002 Jan 01; 99(1):372-4. Kratz CP, Emerling BM, Bonifas J, Wang W, Green ED, Le Beau MM, Shannon KM. PMID: 11756194.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
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