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Jean Nakamura, MD

Title(s)Professor, Radiation Oncology
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone415-514-4997
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    Collapse Biography 
    Collapse Education and Training
    University of Chicago, Chicago, IllinoisA.B.10/1/13Biological Sciences
    University of Chicago, Chicago, IllinoisM.D.1998Pritzker School of Medicine
    University of Chicago, Chicago, IllinoisInternship, Internal Medicine06/1999Internal Medicine
    University of California, San Francisco, San FranciscoResidency06/2003Radiation Oncology
    University of California, San Francisco, San Francisco06/2005Postdoctoral Fellowship
    Collapse Awards and Honors
    UCSF2020UCSF Chancellor's Fund Learning and Development Grant
    2012  - 2015St. Baldrick's Foundation Scholar Award
    American College of Radiolgoy2013Teaching Award

    Collapse Research 
    Collapse Research Activities and Funding
    Utilizing animal models to investigate therapy-induced malignancies
    John Templeton FoundationDec 1, 2019 - Nov 30, 2022
    Role: Co-Investigator
    Mitigating long-term treatment-related morbidity in Childhood Cancer Survivors
    NIH/NCI R35CA220502 01A1Jan 3, 2019 - Jan 4, 2026
    Role: Co-Investigator
    Metabolic vulnerabilities of NF1 mutant tumors
    Department of Defense NF170039Aug 2, 2018 - Aug 1, 2020
    Role: PI
    Developmental and HyperActive Ras Tumor SPORE
    NIH/NCI U54CA196519Sep 1, 2015 - Aug 31, 2020
    Role: Co-Investigator
    The role of mTOR in Ras mediated gliomagenesis
    NIH/NCI K08CA115476Aug 4, 2005 - Jul 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Germline MUTYH Mutation in a Pediatric Cancer Survivor Developing a Secondary Malignancy. J Pediatr Hematol Oncol. 2020 Oct; 42(7):e647-e654. Lavergne V, Sabnis A, Tupule A, Davidson PR, Kline C, Matthay K, Nicolaides T, Goldsby R, Braunstein S, Fogh SE, Sneed PK, Menzel P, Nakamura A, DuBois SG, Haas-Kogan DA, Nakamura JL. PMID: 31815884.
      View in: PubMed   Mentions:    Fields:    
    2. A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection. Neurosurgery. 2020 Aug 29. Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW, Solomon DA, Theodosopoulos PV, Raleigh DR. PMID: 32860417.
      View in: PubMed   Mentions:    Fields:    
    3. Defining the ATPome reveals cross-optimization of metabolic pathways. Nat Commun. 2020 08 28; 11(1):4319. Bennett NK, Nguyen MK, Darch MA, Nakaoka HJ, Cousineau D, Ten Hoeve J, Graeber TG, Schuelke M, Maltepe E, Kampmann M, Mendelsohn BA, Nakamura JL, Nakamura K. PMID: 32859923.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK. Mol Cancer Ther. 2020 Aug 26. Pucciarelli D, Angus SP, Huang B, Zhang C, Nakaoka HJ, Krishnamurthi G, Bandyopadhyay S, Clapp DW, Shannon K, Johnson GL, Nakamura JL. PMID: 32847978.
      View in: PubMed   Mentions:    Fields:    
    5. Stereotactic Radiosurgery to More Than 10 Brain Metastases: Evidence to Support the Role of Radiosurgery for Ideal Hippocampal Sparing in the Treatment of Multiple Brain Metastases. World Neurosurg. 2020 Mar; 135:e174-e180. Susko MS, Garcia MA, Ma L, Nakamura JL, Raleigh DR, Fogh S, Theodosopoulos P, McDermott M, Sneed PK, Braunstein SE. PMID: 31785436.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Subsequent Neoplasms After a Primary Tumor in Individuals With Neurofibromatosis Type 1. J Clin Oncol. 2019 11 10; 37(32):3050-3058. Bhatia S, Chen Y, Wong FL, Hageman L, Smith K, Korf B, Cannon A, Leidy DJ, Paz A, Andress JE, Friedman GK, Metrock K, Neglia JP, Arnold M, Turcotte LM, de Blank P, Leisenring W, Armstrong GT, Robison LL, Clapp DW, Shannon K, Nakamura JL, Fisher MJ. PMID: 31532722.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Reirradiation of recurrent high-grade glioma and development of prognostic scores for progression and survival. Neurooncol Pract. 2019 Sep; 6(5):364-374. Chapman CH, Hara JH, Molinaro AM, Clarke JL, Oberheim Bush NA, Taylor JW, Butowski NA, Chang SM, Fogh SE, Sneed PK, Nakamura JL, Raleigh DR, Braunstein SE. PMID: 31555451.
      View in: PubMed   Mentions:
    8. A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 08; 16(8):e2004624. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K. PMID: 30148842.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    9. Brain metastasis growth on preradiosurgical magnetic resonance imaging. Pract Radiat Oncol. 2018 Nov - Dec; 8(6):e369-e376. Garcia MA, Anwar M, Yu Y, Duriseti S, Merritt B, Nakamura J, Hess C, Theodosopoulos PV, McDermott M, Sneed PK, Braunstein SE. PMID: 30174247.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers. Environ Health. 2018 05 02; 17(1):43. Ojha J, Dyagil I, Finch SC, Reiss RF, de Smith AJ, Gonseth S, Zhou M, Hansen HM, Sherborne AL, Nakamura J, Bracci PM, Gudzenko N, Hatch M, Babkina N, Little MP, Chumak VV, Walsh KM, Bazyka D, Wiemels JL, Zablotska LB. PMID: 29720177.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    11. Mutational landscape of radiation-associated angiosarcoma of the breast. Oncotarget. 2018 Feb 09; 9(11):10042-10053. Thibodeau BJ, Lavergne V, Dekhne N, Benitez P, Amin M, Ahmed S, Nakamura JL, Davidson PR, Nakamura AO, Grills IS, Chen PY, Wobb J, Wilson GD. PMID: 29515789.
      View in: PubMed   Mentions: 4     Fields:    
    12. A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies. Sci Rep. 2017 08 09; 7(1):7645. Davidson PR, Sherborne AL, Taylor B, Nakamura AO, Nakamura JL. PMID: 28794481.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 Jan 01; 80(1):129-139. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro AM, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. PMID: 27428784.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017 Apr 01; 23(7):1852-1861. Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. PMID: 27683180.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Discovery of additional brain metastases on the day of stereotactic radiosurgery: risk factors and outcomes. J Neurosurg. 2017 Jun; 126(6):1756-1763. Garcia MA, Lazar A, Duriseti S, Raleigh DR, Hess CP, Fogh SE, Barani IJ, Nakamura JL, Larson DA, Theodosopoulos P, McDermott M, Sneed PK, Braunstein S. PMID: 27367235.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Parameters influencing local control of meningiomas treated with radiosurgery. J Neurooncol. 2016 06; 128(2):357-64. Kaprealian T, Raleigh DR, Sneed PK, Nabavizadeh N, Nakamura JL, McDermott MW. PMID: 27131883.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. Assessment of image quality and dose calculation accuracy on kV CBCT, MV CBCT, and MV CT images for urgent palliative radiotherapy treatments. J Appl Clin Med Phys. 2016 03 08; 17(2):279-290. Held M, Cremers F, Sneed PK, Braunstein S, Fogh SE, Nakamura J, Barani I, Perez-Andujar A, Pouliot J, Morin O. PMID: 27074487.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. Investigating the clinical advantages of a robotic linac equipped with a multileaf collimator in the treatment of brain and prostate cancer patients. J Appl Clin Med Phys. 2015 09 08; 16(5):284–295. McGuinness CM, Gottschalk AR, Lessard E, Nakamura JL, Pinnaduwage D, Pouliot J, Sims C, Descovich M. PMID: 26699309.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    19. Mutational Analysis of Ionizing Radiation Induced Neoplasms. Cell Rep. 2015 Sep 22; 12(11):1915-26. Sherborne AL, Davidson PR, Yu K, Nakamura AO, Rashid M, Nakamura JL. PMID: 26344771.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    20. Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice. PLoS Genet. 2015 Jun; 11(6):e1005327. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. PMID: 26075392.
      View in: PubMed   Mentions: 1     Fields:    
    21. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice. PLoS Genet. 2015 May; 11(5):e1005235. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. PMID: 26000738.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg. 2015 Aug; 123(2):373-86. Sneed PK, Mendez J, Vemer-van den Hoek JG, Seymour ZA, Ma L, Molinaro AM, Fogh SE, Nakamura JL, McDermott MW. PMID: 25978710.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    23. Interval From Imaging to Treatment Delivery in the Radiation Surgery Age: How Long Is Too Long? Int J Radiat Oncol Biol Phys. 2015 Sep 01; 93(1):126-32. Seymour ZA, Fogh SE, Westcott SK, Braunstein S, Larson DA, Barani IJ, Nakamura J, Sneed PK. PMID: 26279030.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    24. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. . 2015 Feb; 14(2):419-28. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. PMID: 25522764.
      View in: PubMed   Mentions:
    25. Impact of millimeter-level margins on peripheral normal brain sparing for gamma knife radiosurgery. Int J Radiat Oncol Biol Phys. 2014 May 01; 89(1):206-13. Ma L, Sahgal A, Larson DA, Pinnaduwage D, Fogh S, Barani I, Nakamura J, McDermott M, Sneed P. PMID: 24725703.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype. Neuro Oncol. 2014 Mar; 16(3):361-71. Fouse SD, Nakamura JL, James CD, Chang S, Costello JF. PMID: 24311636.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    27. Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk. Front Oncol. 2013; 3:73. Braunstein S, Nakamura JL. PMID: 23565507.
      View in: PubMed   Mentions:
    28. Individual beam sharpening improves composite dose fall-off near a target for non-isocentric cyberknife radiosurgery. Technol Cancer Res Treat. 2013 Aug; 12(4):341-8. Wahl M, Hwang A, Nakamura J, Barani I, Fogh S, Sneed P, McDermott M, Sahgal A, Ma L. PMID: 23369157.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations. J Neurosurg. 2012 Dec; 117 Suppl:115-9. Fogh S, Ma L, Gupta N, Sahgal A, Nakamura JL, Barani I, Sneed PK, McDermott M, Larson DA. PMID: 23205798.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. PMID: 23071067.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    31. A technique for achieving submillimeter accuracy of volume-staged stereotactic radiosurgery. J Radiosurg SBRT. 2012; 2(1):11-17. Ma L, Fogh S, Gupta N, Hwang A, Pinnaduwage D, Nakamura J, Barani I, McDermott M, Sneed PK, Larson DA, Sahgal A. PMID: 29296338.
      View in: PubMed   Mentions:
    32. Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy. Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):303-9. Caballero JA, Sneed PK, Lamborn KR, Ma L, Denduluri S, Nakamura JL, Barani IJ, McDermott MW. PMID: 22079723.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    33. Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery. Phys Med Biol. 2011 Nov 21; 56(22):7247-56. Ma L, Lee L, Barani I, Hwang A, Fogh S, Nakamura J, McDermott M, Sneed P, Larson DA, Sahgal A. PMID: 22037677.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 01; 71(1):106-15. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. PMID: 21199799.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia. J Neurosurg. 2010 Dec; 113 Suppl:199-206. Descovich M, Sneed PK, Barbaro NM, McDermott MW, Chuang CF, Barani IJ, Nakamura JL, Lijun M. PMID: 21222296.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    36. Gamma Knife radiosurgery for brain metastases from primary breast cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 15; 75(4):1132-40. Kased N, Binder DK, McDermott MW, Nakamura JL, Huang K, Berger MS, Wara WM, Sneed PK. PMID: 19345514.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    37. Prognostic factors and grading systems for overall survival in patients treated with radiosurgery for brain metastases: variation by primary site. J Neurosurg. 2008 Dec; 109 Suppl:77-86. Golden DW, Lamborn KR, McDermott MW, Kunwar S, Wara WM, Nakamura JL, Sneed PK. PMID: 19123892.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    38. S6K1 plays a key role in glial transformation. Cancer Res. 2008 Aug 15; 68(16):6516-23. Nakamura JL, Garcia E, Pieper RO. PMID: 18701474.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    39. Glioma invasiveness responds variably to irradiation in a co-culture model. Int J Radiat Oncol Biol Phys. 2007 Nov 01; 69(3):880-6. Nakamura JL, Haas-Kogan DA, Pieper RO. PMID: 17889268.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    40. Gamma knife radiosurgery for brainstem metastases: the UCSF experience. J Neurooncol. 2008 Jan; 86(2):195-205. Kased N, Huang K, Nakamura JL, Sahgal A, Larson DA, McDermott MW, Sneed PK. PMID: 17628747.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    41. The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. Expert Opin Ther Targets. 2007 Apr; 11(4):463-72. Nakamura JL. PMID: 17373877.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    42. mTOR-independent translational control of the extrinsic cell death pathway by RalA. Mol Cell Biol. 2006 Oct; 26(20):7345-57. Panner A, Nakamura JL, Parsa AT, Rodriguez-Viciana P, Berger MS, Stokoe D, Pieper RO. PMID: 16894031.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    43. Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism. Int J Radiat Oncol Biol Phys. 2005 Nov 15; 63(4):1221-7. Gottschalk AR, Doan A, Nakamura JL, Stokoe D, Haas-Kogan DA. PMID: 16253776.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    44. Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism. Int J Radiat Oncol Biol Phys. 2005 Mar 15; 61(4):1183-8. Gottschalk AR, Doan A, Nakamura JL, Haas-Kogan DA, Stokoe D. PMID: 15752900.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    45. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. J Neurooncol. 2005 Feb; 71(3):215-22. Nakamura JL, Karlsson A, Arvold ND, Gottschalk AR, Pieper RO, Stokoe D, Haas-Kogan DA. PMID: 15735908.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    46. Comparison of intensity-modulated radiosurgery with gamma knife radiosurgery for challenging skull base lesions. Int J Radiat Oncol Biol Phys. 2003 Jan 01; 55(1):99-109. Nakamura JL, Pirzkall A, Carol MP, Xia P, Smith V, Wara WM, Petti PL, Verhey LJ, Sneed PK. PMID: 12504041.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    47. Dose conformity of gamma knife radiosurgery and risk factors for complications. Int J Radiat Oncol Biol Phys. 2001 Dec 01; 51(5):1313-9. Nakamura JL, Verhey LJ, Smith V, Petti PL, Lamborn KR, Larson DA, Wara WM, McDermott MW, Sneed PK. PMID: 11728692.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
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