Buck Strewler, MD

Title(s)Professor & Senior Advisor, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
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    Collapse Biography 
    Collapse Education and Training
    Dartmouth CollegeA.B.1968
    Harvard Medical SchoolM.D.1971
    Peter Bent Brigham HospitalInternship and Residency1973
    Collapse Awards and Honors
    1987American Society for Clinical Investigation
    1996Best Doctors in America
    HMS Second Year Class2003Best Lecturer, Module 2
    Harvard Medical School2003Elected to Aesculapian Club
    Boston Magazine2006Best Doctors in Boston
    Dept of Medicine, Beth Israel Deaconess2009Mentorship of Resident Research Award
    Harvard Medical School2014Tutorial Excellence Award

    Collapse Overview 
    Collapse Overview
    Gordon "Buck" Strewler grew up in northern Minnesota and graduated from Dartmouth College and Harvard Medical School. He was an intern and resident at Peter Bent Brigham Hospital, the predecessor of Brigham and Women's. After clinical and research training in Endocrinology-Metabolism at the National Institutes of Health, he joined the UCSF faculty in 1979. He is an expert in calcium and bone metabolism; With Robert Nissenson, PhD,his laboratory identified, sequenced and cloned the parathyroid hormone-related protein, PTHrP, developed an assay to detect PTHrP in patients with hypercalcemia, and led the way to the understanding of its role in disease. He was Chief of the Endocrine Unit at the SFVAMC and also directed the UCSF Endocrinology Fellowship Program. Dr. Strewler returned to Boston in 1996. He was Chief of Medicine at the West Roxbury VA Medical Center (now part of the VA Boston Healthcare System) until 2001, when he became Master of the Walter Bradford Cannon Society, one of five learning communities in which Harvard medical students spend their academic lives. He subsequently became Director of the Scholars in Medicine program at HMS and Vice Chair for Education in the department of medicine at Beth Israel Deaconess Medical Center. He returned to UCSF in September, 2015 to join the Inquiry leadership team.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Update: A 64-year-old woman with primary hyperparathyroidism. JAMA. 2008 Nov 05; 300(17):2044-5. Farag N, Delbanco T, Strewler GJ. PMID: 18984891.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Untangling klotho's role in calcium homeostasis. Cell Metab. 2007 Aug; 6(2):93-5. Strewler GJ. PMID: 17681143.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    3. Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy. J Oral Maxillofac Surg. 2007 Jul; 65(7):1328-31. Wang EP, Kaban LB, Strewler GJ, Raje N, Troulis MJ. PMID: 17577497.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    4. A 64-year-old woman with primary hyperparathyroidism. JAMA. 2005 Apr 13; 293(14):1772-9. Strewler GJ. PMID: 15827317.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Physiology: do neural signals remodel bone? Nature. 2005 Mar 24; 434(7032):447-8. Elmquist JK, Strewler GJ. PMID: 15791237.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Decimal point--osteoporosis therapy at the 10-year mark. N Engl J Med. 2004 Mar 18; 350(12):1172-4. Strewler GJ. PMID: 15028820.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    7. FGF23, hypophosphatemia, and rickets: has phosphatonin been found? Proc Natl Acad Sci U S A. 2001 May 22; 98(11):5945-6. Strewler GJ. PMID: 11371627.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    8. Local and systemic control of the osteoblast. J Clin Invest. 2001 Feb; 107(3):271-2. Strewler GJ. PMID: 11160149.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Medical approaches to primary hyperparathyroidism. Endocrinol Metab Clin North Am. 2000 Sep; 29(3):523-39, vi. Strewler GJ. PMID: 11033759.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. The parathyroid hormone-related protein. Endocrinol Metab Clin North Am. 2000 Sep; 29(3):629-45. Strewler GJ. PMID: 11033764.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    11. The physiology of parathyroid hormone-related protein. N Engl J Med. 2000 Jan 20; 342(3):177-85. Strewler GJ. PMID: 10639544.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    12. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology. 1999 Apr; 140(4):1911-9. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. PMID: 10098531.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model. J Bone Miner Res. 1996 May; 11(5):614-25. Lane NE, Kimmel DB, Nilsson MH, Cohen FE, Newton S, Nissenson RA, Strewler GJ. PMID: 9157776.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Parathyroid hormone-related protein is induced during lethal endotoxemia and contributes to endotoxin-induced mortality in rodents. Mol Med. 1996 Mar; 2(2):204-10. Funk JL, Moser AH, Strewler GJ, Feingold KR, Grünfeld C. PMID: 8726463.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Intermittent treatment with human parathyroid hormone (hPTH[1-34]) increased trabecular bone volume but not connectivity in osteopenic rats. J Bone Miner Res. 1995 Oct; 10(10):1470-7. Lane NE, Thompson JM, Strewler GJ, Kinney JH. PMID: 8686502.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    16. Endotoxin induces parathyroid hormone-related protein gene expression in splenic stromal and smooth muscle cells, not in splenic lymphocytes. Endocrinology. 1995 Aug; 136(8):3412-21. Funk JL, Lausier J, Moser AH, Shigenaga JK, Huling S, Nissenson RA, Strewler GJ, Grunfeld C, Feingold KR. PMID: 7628377.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    17. Indications for surgery in patients with minimally symptomatic primary hyperparathyroidism. Surg Clin North Am. 1995 Jun; 75(3):439-47. Strewler GJ. PMID: 7747251.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment. J Bone Miner Res. 1994 Jul; 9(7):1041-6. Schermer DT, Bradley MS, Bambino TH, Nissenson RA, Strewler GJ. PMID: 7942150.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Cytokine regulation of parathyroid hormone-related protein messenger ribonucleic acid levels in mouse spleen: paradoxical effects of interferon-gamma and interleukin-4. Endocrinology. 1994 Jul; 135(1):351-8. Funk JL, Shigenaga JK, Moser AH, Krul EJ, Strewler GJ, Feingold KR, Grunfeld C. PMID: 7516868.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Familial benign hypocalciuric hypercalcemia--from the clinic to the calcium sensor. West J Med. 1994 Jun; 160(6):579-80. Strewler GJ. PMID: 8053190.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Endotoxin increases parathyroid hormone-related protein mRNA levels in mouse spleen. Mediation by tumor necrosis factor. J Clin Invest. 1993 Nov; 92(5):2546-52. Funk JL, Krul EJ, Moser AH, Shigenaga JK, Strewler GJ, Grunfeld C, Feingold KR. PMID: 8227368.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient. J Clin Endocrinol Metab. 1993 May; 76(5):1373-5. Strewler GJ, Budayr AA, Clark OH, Nissenson RA. PMID: 7684395.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    23. Hypercalcaemia and elevated levels of parathyroid hormone-related protein in cutaneous squamous/basal cell carcinoma. J Intern Med. 1993 Feb; 233(2):205-7. Marino MT, Asp AA, Budayer AA, Marsden JS, Strewler GJ. PMID: 8433083.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. J Biol Chem. 1992 Dec 15; 267(35):25202-7. Chan SD, Karpf DB, Fowlkes ME, Hooks M, Bradley MS, Vuong V, Bambino T, Liu MY, Arnaud CD, Strewler GJ. PMID: 1334084.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    25. Actions of parathyroid hormone-related protein as an embryonic differentiation factor. J Endocrinol Invest. 1992; 15(9 Suppl 6):57-62. Strewler GJ, Chan SD, Globus RK, Schermer DT, Nissenson RA. PMID: 1300340.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    26. Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. J Pharmacol Exp Ther. 1991 Sep; 258(3):877-81. Klein RF, Nissenson RA, Strewler GJ. PMID: 1653845.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    27. Chicken parathyroid hormone-related protein and its expression during embryologic development. J Bone Miner Res. 1991 Feb; 6(2):149-55. Schermer DT, Chan SD, Bruce R, Nissenson RA, Wood WI, Strewler GJ. PMID: 1709333.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone. J Biol Chem. 1991 Jan 25; 266(3):1997-2004. Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA. PMID: 1846369.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. Hypercalcemia in malignancy. West J Med. 1990 Dec; 153(6):635-40. Strewler GJ, Nissenson RA. PMID: 2293469.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    30. Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells. J Biol Chem. 1990 Nov 25; 265(33):20081-4. Chan SD, Strewler GJ, Nissenson RA. PMID: 2122968.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    31. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Mol Endocrinol. 1990 Apr; 4(4):638-46. Chan SD, Strewler GJ, King KL, Nissenson RA. PMID: 2177844.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. Peptide mediators of hypercalcemia in malignancy. Annu Rev Med. 1990; 41:35-44. Strewler GJ, Nissenson RA. PMID: 2184736.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    33. Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia. Ann Intern Med. 1989 Nov 15; 111(10):807-12. Budayr AA, Nissenson RA, Klein RF, Pun KK, Clark OH, Diep D, Arnaud CD, Strewler GJ. PMID: 2817628.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    34. High levels of a parathyroid hormone-like protein in milk. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7183-5. Budayr AA, Halloran BP, King JC, Diep D, Nissenson RA, Strewler GJ. PMID: 2550932.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    35. Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem. 1988 Sep 15; 263(26):12866-71. Nissenson RA, Diep D, Strewler GJ. PMID: 2843501.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    36. Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro. Bone Miner. 1988 Jul; 4(3):247-56. Klein RF, Nissenson RA, Strewler GJ. PMID: 2847839.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    37. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4605-9. Thiede MA, Strewler GJ, Nissenson RA, Rosenblatt M, Rodan GA. PMID: 3290897.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    38. Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest. 1987 Dec; 80(6):1803-7. Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson RA. PMID: 3680530.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    39. Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity. Endocrinology. 1987 Feb; 120(2):504-11. Klein RF, Strewler GJ, Leung SC, Nissenson RA. PMID: 3026777.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Nonparathyroid hypercalcemia. Adv Intern Med. 1987; 32:235-58. Strewler GJ, Nissenson RA. PMID: 3030065.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Pathogenesis of hypercalcemia in nude mice bearing a human renal carcinoma. Endocrinology. 1986 Jul; 119(1):303-10. Strewler GJ, Wronski TJ, Halloran BP, Miller SC, Leung SC, Williams RD, Nissenson RA. PMID: 3013591.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    42. Parathyroid hormone inhibition of Na+-H+ antiporter activity in a cultured renal cell line. Am J Physiol. 1986 Feb; 250(2 Pt 2):F217-25. Pollock AS, Warnock DG, Strewler GJ. PMID: 2418691.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    43. Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor. Cancer Res. 1985 Nov; 45(11 Pt 1):5358-63. Nissenson RA, Strewler GJ, Williams RD, Leung SC. PMID: 2996759.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    44. Human transforming growth factor-alpha stimulates bone resorption in vitro. J Clin Invest. 1985 Nov; 76(5):2016-9. Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ. PMID: 3877079.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    45. Bone disease in alcohol abuse. Ann Intern Med. 1985 Jul; 103(1):42-8. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. PMID: 2988390.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    46. Biologic regulation of Na/H antiporter activity in a cultured kidney cell line: effects of parathyroid hormone (PTH). Ann N Y Acad Sci. 1985; 456:451-3. Pollock AS, Strewler GJ, Miller RT, Lawlor D, Horowitz DD, Warnock DG. PMID: 3867312.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    47. Paget's disease of bone. West J Med. 1984 May; 140(5):763-8. Strewler GJ. PMID: 6730492.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Parathyroid hormone receptors coupled to cyclic adenosine monophosphate formation in an established renal cell line. Endocrinology. 1984 Mar; 114(3):980-5. Teitelbaum AP, Strewler GJ. PMID: 6321147.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    49. Release of cAMP from a renal epithelial cell line. Am J Physiol. 1984 Mar; 246(3 Pt 1):C224-30. Strewler GJ. PMID: 6322592.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Probenecid inhibits the secretion of nephrogenous adenosine 3',5'-monophosphate in normal man. J Clin Endocrinol Metab. 1983 Oct; 57(4):689-93. Gogel E, Halloran BP, Strewler GJ. PMID: 6309880.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    51. Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells. Biochem J. 1983 Aug 01; 213(2):379-86. Strewler GJ, Danello MA, Manganiello VC, Vaughan M. PMID: 6311163.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    52. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest. 1983 Mar; 71(3):769-74. Strewler GJ, Williams RD, Nissenson RA. PMID: 6298282.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    53. Defective protein phosphorylation in renal medulla of vasopressin-resistant mice. Biochem Biophys Res Commun. 1981 Nov 30; 103(2):713-20. Strewler GJ, Fallon BG, Orloff J. PMID: 7332566.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    54. Regulation of cyclic nucleotide phosphodiesterase activity. Adv Cyclic Nucleotide Res. 1981; 14:263-71. Vaughan M, Danello MA, Manganiello VC, Strewler GJ. PMID: 6169258.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    55. Purification and characterization of phosphodiesterase activator from kidney. A lysosomal protease. J Biol Chem. 1979 Dec 10; 254(23):11891-8. Strewler GJ, Manganiello VC. PMID: 227882.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    56. Stimulation of adenylate cyclase activity by a protease which activates cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun. 1979 Oct 29; 90(4):1159-65. Pinkett MO, Strewler GJ, Anderson WB. PMID: 229831.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    57. Phosphodiesterase activator from rat kidney cortex. J Biol Chem. 1978 Jan 25; 253(2):390-4. Strewler GJ, Manganiello VC, Vaughan M. PMID: 201632.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    58. Adriamycin therapy for advanced insulinoma. J Clin Endocrinol Metab. 1977 Jan; 44(1):142-8. Eastman RC, Come SE, Strewler GJ, Gorden P, Kahn CR. PMID: 188859.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    59. Role of cyclic nucleotides in the transport of water and electrolytes. Adv Cyclic Nucleotide Res. 1977; 8:311-61. Strewler GJ, Orloff J. PMID: 200128.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    60. Delayed overt hemolytic transfusion reaction due to anti-U antibody. Transfusion. 1976 Jul-Aug; 16(4):357-60. Rothman IK, Alter HJ, Strewler GJ. PMID: 951732.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    61. Pseudo-vitamin D deficiency rickets (PDR) and relative hypoparathyroidism: a report of a family. J Clin Endocrinol Metab. 1973 Aug; 37(2):220-9. Strewler GJ, Bernstein DS, Pletka P. PMID: 4720069.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    62. Sodium intake and vascular smooth muscle responsiveness to norepinephrine and angiotensin in the rabbit. Circ Res. 1972 Nov; 31(5):758-66. Strewler GJ, Hinrichs KJ, Guiod LR, Hollenberg NK. PMID: 4343577.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    63. Hemiparesis occurring six hours after intravenous heroin injection. Neurology. 1972 Aug; 22(8):863-6. Woods BT, Strewler GJ. PMID: 4673415.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    64. Excretion and distribution of iophenoxic acid. J Pharmacol Exp Ther. 1971 Jul; 178(1):159-72. Mudge GH, Strewler GJ, Desbiens N, Berndt WO, Wade DN. PMID: 5087394.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    65. Metabolism of iophenoxic acid in the dog. J Pharmacol Exp Ther. 1971 Jul; 178(1):173-9. Wade DN, Desbiens N, Strewler GJ, Berndt WO, Mudge GH. PMID: 5087395.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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