Rik Derynck, PhD

InstitutionUniversity of California San Francisco
DepartmentCell and Tissue Biology
Address35 Medical Center way
San Fancisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    Central role of ShcA in differential TGF-beta signaling, epithelial plasticity and carcinoma cell behavior
    NIH/NCI R01CA198179Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    TGF-b family signaling in cardiomyocyte differentiation from embryonic stem cells
    NIH/NHLBI R21HL092394Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Regulatory non-Smad signaling in TGF-b-induced epithelial-mesenchymal transition
    NIH/NCI R01CA136690Jan 1, 2009 - Dec 31, 2018
    Role: Principal Investigator
    Conversion of pre-adipose cells into muscle cells
    NIH/NIAMS R21AR054746Jul 15, 2008 - Mar 31, 2011
    Role: Principal Investigator
    TGF-beta receptor sumoylation and cell behavior
    NIH/NCI R21CA125190Dec 14, 2006 - Nov 30, 2008
    Role: Principal Investigator
    TGF-Beta Superfamily: Signaling and Development
    NIH/NICHD R13HD044643Jul 12, 2003 - Jul 11, 2004
    Role: Principal Investigator
    NIH/NICHD R13HD040990Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    NIH/NIDCR P01DE013904Jun 1, 2001 - May 31, 2008
    Role: Co-Investigator
    NIH/NIDCR P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    Molecular Basis of Lung Morphogenesis Injury &Repair
    NIH/NHLBI P01HL060231Apr 1, 1998 - Mar 31, 2011
    Role: Co-Investigator
    Functional crosstalk of TGF-beta/Smad signaling with methyl transferases
    NIH/NCI R01CA063101Jan 1, 1995 - Jan 31, 2015
    Role: Principal Investigator
    NIH/NIAMS R01AR041126May 1, 1993 - Apr 30, 1998
    Role: Principal Investigator
    NIH/NIDCR P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    NIH/NIAMS R55AR041126Sep 1, 1992 - Apr 30, 1993
    Role: Principal Investigator
    NIH/NCI R01CA054826Apr 8, 1992 - Dec 31, 2005
    Role: Principal Investigator
    NIH/NIGMS R13GM047154Mar 1, 1992 - Feb 28, 1993
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Katsuno Y, Qin J, Oses-Prieto JA, Wang H, Jackson-Weaver O, Zhang T, Lamouille S, Wu J, Burlingame ALL, Xu J, Derynck R. Arginine methylation of Smad7 by PRMT1 in TGF-ß-induced epithelial-mesenchymal transition and epithelial stem cell generation. J Biol Chem. 2018 Jun 15. PMID: 29907569.
      View in: PubMed
    2. Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R. Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition. EMBO Rep. 2018 Jan; 19(1):135-155. PMID: 29233829.
      View in: PubMed
    3. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. PMID: 28872461.
      View in: PubMed
    4. Budi EH, Duan D, Derynck R. Transforming Growth Factor-ß Receptors and Smads: Regulatory Complexity and Functional Versatility. Trends Cell Biol. 2017 09; 27(9):658-672. PMID: 28552280.
      View in: PubMed
    5. Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12478-12483. PMID: 27738243.
      View in: PubMed
    6. Moses HL, Roberts AB, Derynck R. The Discovery and Early Days of TGF-ß: A Historical Perspective. Cold Spring Harb Perspect Biol. 2016 Jul 01; 8(7). PMID: 27328871.
      View in: PubMed
    7. Morikawa M, Derynck R, Miyazono K. TGF-ß and the TGF-ß Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5). PMID: 27141051.
      View in: PubMed
    8. Budi EH, Xu J, Derynck R. Regulation of TGF-ß Receptors. Methods Mol Biol. 2016; 1344:1-33. PMID: 26520115.
      View in: PubMed
    9. Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R. ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-ß-Induced Smad Activation. PLoS Biol. 2015 Dec; 13(12):e1002325. PMID: 26680585; PMCID: PMC4682977.
    10. Budi EH, Muthusamy BP, Derynck R. The insulin response integrates increased TGF-ß signaling through Akt-induced enhancement of cell surface delivery of TGF-ß receptors. Sci Signal. 2015 Sep 29; 8(396):ra96. PMID: 26420907; PMCID: PMC4669960.
    11. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. PMID: 25526531; PMCID: PMC4273650 [Available on 12/18/15].
    12. Derynck R, Muthusamy BP, Saeteurn KY. Signaling pathway cooperation in TGF-ß-induced epithelial-mesenchymal transition. Curr Opin Cell Biol. 2014 Dec; 31:56-66. PMID: 25240174; PMCID: PMC4657734.
    13. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. Pillars Article: production of transforming growth factor ß by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050. J Immunol. 2014 Apr 01; 192(7):2939-52. PMID: 24659787.
      View in: PubMed
    14. Xu J, Derynck R. Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014; 13(8):1209-10. PMID: 24621505; PMCID: PMC4049950.
    15. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96. PMID: 24556840; PMCID: PMC4240281.
    16. Derynck R, Akhurst RJ. BMP-9 balances endothelial cell fate. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18746-7. PMID: 24222686; PMCID: PMC3839760.
    17. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19. PMID: 23747011; PMCID: PMC3951972.
    18. Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013 Jun 21; 288(25):18546-60. PMID: 23649632; PMCID: PMC3689995.
    19. Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7. PMID: 23434068; PMCID: PMC4240277.
    20. Katsuno Y, Lamouille S, Derynck R. TGF-ß signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 2013 Jan; 25(1):76-84. PMID: 23197193.
      View in: PubMed
    21. Sakaki-Yumoto M, Katsuno Y, Derynck R. TGF-ß family signaling in stem cells. Biochim Biophys Acta. 2013 Feb; 1830(2):2280-96. PMID: 22959078; PMCID: PMC4240309.
    22. Xu P, Liu J, Derynck R. Post-translational regulation of TGF-ß receptor and Smad signaling. FEBS Lett. 2012 Jul 04; 586(14):1871-84. PMID: 22617150; PMCID: PMC4240271.
    23. Xu P, Liu J, Sakaki-Yumoto M, Derynck R. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci Signal. 2012 May 01; 5(222):ra34. PMID: 22550340; PMCID: PMC4254802.
    24. Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. TGF-ß-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci. 2012 Mar 01; 125(Pt 5):1259-73. PMID: 22399812; PMCID: PMC3324583.
    25. Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7820-5. PMID: 21518866; PMCID: PMC3093514.
    26. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May; 29(5):443-8. PMID: 21490602; PMCID: PMC3685579.
    27. Lamouille S, Derynck R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-ß-induced epithelial-mesenchymal transition. Cells Tissues Organs. 2011; 193(1-2):8-22. PMID: 21041997; PMCID: PMC3030503.
    28. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71. PMID: 20847738; PMCID: PMC2948188.
    29. Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010 Feb 26; 37(4):551-66. PMID: 20188673; PMCID: PMC4240279.
    30. Lamouille S, Derynck R. Oncogene and tumour suppressor: the two faces of SnoN. EMBO J. 2009 Nov 18; 28(22):3459-60. PMID: 19920850; PMCID: PMC2782103.
    31. Wharton K, Derynck R. TGFbeta family signaling: novel insights in development and disease. Development. 2009 Nov; 136(22):3691-7. PMID: 19855012.
      View in: PubMed
    32. Piscopo DM, Johansen EB, Derynck R. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J Biol Chem. 2009 Nov 13; 284(46):31690-703. PMID: 19759027; PMCID: PMC2797240.
    33. Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug; 19(8):385-94. PMID: 19648010.
      View in: PubMed
    34. Liu C, Xu P, Lamouille S, Xu J, Derynck R. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36. PMID: 19595713; PMCID: PMC2740991.
    35. Wu L, Derynck R. Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Dev Cell. 2009 Jul; 17(1):35-48. PMID: 19619490; PMCID: PMC2722039.
    36. Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72. PMID: 19153598; PMCID: PMC4720263.
    37. Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J. 2009 Jan 21; 28(2):88-98. PMID: 19096363; PMCID: PMC2634733.
    38. Imhof I, Gasper WJ, Derynck R. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. J Cell Sci. 2008 Jul 01; 121(Pt 13):2265-74. PMID: 18544636.
      View in: PubMed
    39. Kang JS, Saunier EF, Akhurst RJ, Derynck R. The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nat Cell Biol. 2008 Jun; 10(6):654-64. PMID: 18469808; PMCID: PMC2649123.
    40. Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T. Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One. 2009; 4(4):e5275. PMID: 19357790; PMCID: PMC2666804.
    41. Derynck R, Akhurst RJ. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol. 2007 Sep; 9(9):1000-4. PMID: 17762890.
      View in: PubMed
    42. Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 2007 Sep 05; 26(17):3957-67. PMID: 17673906; PMCID: PMC1994119.
    43. Lamouille S, Derynck R. Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 2007 Jul 30; 178(3):437-51. PMID: 17646396; PMCID: PMC2064840.
    44. Castro CP, Piscopo D, Nakagawa T, Derynck R. Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. J Cell Sci. 2007 Jul 15; 120(Pt 14):2454-66. PMID: 17607000.
      View in: PubMed
    45. Wan DC, Aalami OO, Wang Z, Nacamuli RP, Lorget F, Derynck R, Longaker MT. Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone. Plast Reconstr Surg. 2006 Sep 15; 118(4):851-61. PMID: 16980845.
      View in: PubMed
    46. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18813-8. PMID: 16354837; PMCID: PMC1323171.
    47. Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science. 2005 Oct 07; 310(5745):68-71. PMID: 16210527.
      View in: PubMed
    48. Qin BY, Liu C, Srinath H, Lam SS, Correia JJ, Derynck R, Lin K. Crystal structure of IRF-3 in complex with CBP. Structure. 2005 Sep; 13(9):1269-77. PMID: 16154084.
      View in: PubMed
    49. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug; 233(4):1315-31. PMID: 15965977.
      View in: PubMed
    50. Kang JS, Alliston T, Delston R, Derynck R. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005 Jul 20; 24(14):2543-55. PMID: 15990875; PMCID: PMC1176457.
    51. Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005 Jun 24; 280(25):24227-37. PMID: 15849193.
      View in: PubMed
    52. Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol. 2005; 21:659-93. PMID: 16212511.
      View in: PubMed
    53. Pardoux C, Derynck R. JNK regulates expression and autocrine signaling of TGF-beta1. Mol Cell. 2004 Jul 23; 15(2):170-1. PMID: 15260968.
      View in: PubMed
    54. Liu D, Kang JS, Derynck R. TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 2004 Apr 07; 23(7):1557-66. PMID: 15044954; PMCID: PMC391082.
    55. Qing J, Liu C, Choy L, Wu RY, Pagano JS, Derynck R. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol. 2004 Feb; 24(3):1411-25. PMID: 14729983; PMCID: PMC321430.
    56. Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat Struct Biol. 2003 Nov; 10(11):913-21. PMID: 14555996.
      View in: PubMed
    57. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003 Oct 09; 425(6958):577-84. PMID: 14534577.
      View in: PubMed
    58. Lee PS, Chang C, Liu D, Derynck R. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. J Biol Chem. 2003 Jul 25; 278(30):27853-63. PMID: 12740389.
      View in: PubMed
    59. Fan H, Turck CW, Derynck R. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem. 2003 May 16; 278(20):18617-27. PMID: 12621058.
      View in: PubMed
    60. Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem. 2003 Mar 14; 278(11):9609-19. PMID: 12524424.
      View in: PubMed
    61. Skillington J, Choy L, Derynck R. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol. 2002 Oct 14; 159(1):135-46. PMID: 12379805; PMCID: PMC2173483.
    62. Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. PMID: 12161428.
      View in: PubMed
    63. Alliston T, Derynck R. Medicine: interfering with bone remodelling. Nature. 2002 Apr 18; 416(6882):686-7. PMID: 11961535.
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