Rik Derynck, PhD

Title(s)Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address35 Medical Center Way
San Francisco CA 94143
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    Central role of ShcA in differential TGF-beta signaling, epithelial plasticity and carcinoma cell behavior
    NIH R01CA198179Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    TGF-b family signaling in cardiomyocyte differentiation from embryonic stem cells
    NIH R21HL092394Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Regulatory non-Smad signaling in TGF-b-induced epithelial-mesenchymal transition
    NIH R01CA136690Jan 1, 2009 - Dec 31, 2019
    Role: Principal Investigator
    Conversion of pre-adipose cells into muscle cells
    NIH R21AR054746Jul 15, 2008 - Mar 31, 2011
    Role: Principal Investigator
    TGF-beta receptor sumoylation and cell behavior
    NIH R21CA125190Dec 14, 2006 - Nov 30, 2008
    Role: Principal Investigator
    TGF-Beta Superfamily: Signaling and Development
    NIH R13HD044643Jul 12, 2003 - Jul 11, 2004
    Role: Principal Investigator
    NIH R13HD040990Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    NIH P01DE013904Jun 1, 2001 - May 31, 2008
    Role: Co-Investigator
    NIH P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    Molecular Basis of Lung Morphogenesis Injury &Repair
    NIH P01HL060231Apr 1, 1998 - Mar 31, 2011
    Role: Co-Investigator
    Functional crosstalk of TGF-beta/Smad signaling with methyl transferases
    NIH R01CA063101Jan 1, 1995 - Jan 31, 2017
    Role: Principal Investigator
    NIH R01AR041126May 1, 1993 - Apr 30, 1998
    Role: Principal Investigator
    NIH P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    NIH R55AR041126Sep 1, 1992 - Apr 30, 1993
    Role: Principal Investigator
    NIH R01CA054826Apr 8, 1992 - Dec 31, 2005
    Role: Principal Investigator
    NIH R13GM047154Mar 1, 1992 - Feb 28, 1993
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TGF-ß as a driver of fibrosis: physiological roles and therapeutic opportunities. J Pathol. 2021 Apr 08. Budi EH, Schaub JR, Decaris M, Turner S, Derynck R. PMID: 33834494.
      View in: PubMed   Mentions:    Fields:    
    2. Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-ß family. Dev Cell. 2021 Mar 22; 56(6):726-746. Katsuno Y, Derynck R. PMID: 33756119.
      View in: PubMed   Mentions: 1     Fields:    
    3. TGFß biology in cancer progression and immunotherapy. Nat Rev Clin Oncol. 2021 01; 18(1):9-34. Derynck R, Turley SJ, Akhurst RJ. PMID: 32710082.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    4. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020 06; 21(6):341-352. Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RJY, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA) . PMID: 32300252.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimals
    5. Integration of TGF-ß-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells. Sci Rep. 2019 11 18; 9(1):16992. Budi EH, Hoffman S, Gao S, Zhang YE, Derynck R. PMID: 31740700.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. EMT and Cancer: More Than Meets the Eye. Dev Cell. 2019 05 06; 49(3):313-316. Derynck R, Weinberg RA. PMID: 31063750.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    7. Transforming growth factor-ß (TGF-ß)-induced up-regulation of TGF-ß receptors at the cell surface amplifies the TGF-ß response. J Biol Chem. 2019 05 24; 294(21):8490-8504. Duan D, Derynck R. PMID: 30948511.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    8. Specificity, versatility, and control of TGF-ß family signaling. Sci Signal. 2019 02 26; 12(570). Derynck R, Budi EH. PMID: 30808818.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    9. Chronic TGF-ß exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Sci Signal. 2019 02 26; 12(570). Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R. PMID: 30808819.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    10. Enhanced TGF-ß Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells. iScience. 2019 Jan 25; 11:474-491. Budi EH, Mamai O, Hoffman S, Akhurst RJ, Derynck R. PMID: 30684493.
      View in: PubMed   Mentions:
    11. Arginine methylation of SMAD7 by PRMT1 in TGF-ß-induced epithelial-mesenchymal transition and epithelial stem-cell generation. J Biol Chem. 2018 08 24; 293(34):13059-13072. Katsuno Y, Qin J, Oses-Prieto J, Wang H, Jackson-Weaver O, Zhang T, Lamouille S, Wu J, Burlingame A, Xu J, Derynck R. PMID: 29907569.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    12. Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition. EMBO Rep. 2018 01; 19(1):135-155. Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R. PMID: 29233829.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    13. Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. PMID: 28872461.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    14. Transforming Growth Factor-ß Receptors and Smads: Regulatory Complexity and Functional Versatility. Trends Cell Biol. 2017 09; 27(9):658-672. Budi EH, Duan D, Derynck R. PMID: 28552280.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    15. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12478-12483. Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K. PMID: 27738243.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    16. The Discovery and Early Days of TGF-ß: A Historical Perspective. Cold Spring Harb Perspect Biol. 2016 07 01; 8(7). Moses HL, Roberts AB, Derynck R. PMID: 27328871.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    17. TGF-ß and the TGF-ß Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5). Morikawa M, Derynck R, Miyazono K. PMID: 27141051.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    18. Regulation of TGF-ß Receptors. Methods Mol Biol. 2016; 1344:1-33. Budi EH, Xu J, Derynck R. PMID: 26520115.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-ß-Induced Smad Activation. PLoS Biol. 2015 Dec; 13(12):e1002325. Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R. PMID: 26680585.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    20. The insulin response integrates increased TGF-ß signaling through Akt-induced enhancement of cell surface delivery of TGF-ß receptors. Sci Signal. 2015 Sep 29; 8(396):ra96. Budi EH, Muthusamy BP, Derynck R. PMID: 26420907.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    21. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. PMID: 25526531.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    22. Signaling pathway cooperation in TGF-ß-induced epithelial-mesenchymal transition. Curr Opin Cell Biol. 2014 Dec; 31:56-66. Derynck R, Muthusamy BP, Saeteurn KY. PMID: 25240174.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    23. Pillars Article: production of transforming growth factor ß by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050. J Immunol. 2014 Apr 01; 192(7):2939-52. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. PMID: 24659787.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Does Smad6 methylation control BMP signaling in cancer? . 2014; 13(8):1209-10. Xu J, Derynck R. PMID: 24621505.
      View in: PubMed   Mentions:
    25. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96. Lamouille S, Xu J, Derynck R. PMID: 24556840.
      View in: PubMed   Mentions: 2365     Fields:    Translation:HumansCells
    26. BMP-9 balances endothelial cell fate. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18746-7. Derynck R, Akhurst RJ. PMID: 24222686.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. S-1 Complexity of cytokines in Treg function and stability. Cytokine. 2013 Sep 1; 63(3):241. Jeffrey A. Bluestone, Samantha Bailey-Bucktrout, Pinglong Xu, Rik Derynck, Elenora Trotta, Natasha Crellins, Isaac Rondon, Michael DuPage, Mark Travis, Dean Sheppard. .
      View in: Publisher Site   Mentions:
    28. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. PMID: 23747011.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    29. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013 Jun 21; 288(25):18546-60. Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R. PMID: 23649632.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    30. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7. Lamouille S, Subramanyam D, Blelloch R, Derynck R. PMID: 23434068.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    31. TGF-ß signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 2013 Jan; 25(1):76-84. Katsuno Y, Lamouille S, Derynck R. PMID: 23197193.
      View in: PubMed   Mentions: 319     Fields:    Translation:HumansAnimalsCells
    32. 578 High Content Analysis of the Epithelial-Mesenchymal Transition to Identify Novel Targets in Cancer Progression. European Journal of Cancer. 2012 Nov 1; 48:177. S. Lamouille, R. Judson, R. Blelloch, R. Derynck. .
      View in: Publisher Site   Mentions:
    33. TGF-ß family signaling in stem cells. Biochim Biophys Acta. 2013 Feb; 1830(2):2280-96. Sakaki-Yumoto M, Katsuno Y, Derynck R. PMID: 22959078.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    34. Post-translational regulation of TGF-ß receptor and Smad signaling. FEBS Lett. 2012 Jul 04; 586(14):1871-84. Xu P, Liu J, Derynck R. PMID: 22617150.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    35. TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. Development. 2012 May 15; 139(10):e1008-e1008. S. Lamouille, E. Connolly, J. W. Smyth, R. J. Akhurst, R. Derynck. .
      View in: Publisher Site   Mentions:
    36. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci Signal. 2012 May 01; 5(222):ra34. Xu P, Liu J, Sakaki-Yumoto M, Derynck R. PMID: 22550340.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    37. TGF-ß-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci. 2012 Mar 01; 125(Pt 5):1259-73. Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. PMID: 22399812.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    38. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7820-5. Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. PMID: 21518866.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    39. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May; 29(5):443-8. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. PMID: 21490602.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansCells
    40. Stem cell antigen-1 (Sca-1) disrupts GDF10/TGF-ß signal transduction at the plasma membrane to regulate Smad2/3 nuclear signaling. The FASEB Journal. 2011 Apr 1; 25:243.5-243.5. Geeta Upadhyay, Yuzhi Yin, Hongyan Yuan, Levy Kopelovich, Rik Derynck, Robert I. Glazer. .
      View in: Publisher Site   Mentions:
    41. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-ß-induced epithelial-mesenchymal transition. Cells Tissues Organs. 2011; 193(1-2):8-22. Lamouille S, Derynck R. PMID: 21041997.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    42. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. . 2010 Oct; 11(10):765-71. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. PMID: 20847738.
      View in: PubMed   Mentions:
    43. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010 Feb 26; 37(4):551-66. Xu P, Derynck R. PMID: 20188673.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    44. Oncogene and tumour suppressor: the two faces of SnoN. EMBO J. 2009 Nov 18; 28(22):3459-60. Lamouille S, Derynck R. PMID: 19920850.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    45. TGFbeta family signaling: novel insights in development and disease. Development. 2009 Nov; 136(22):3691-7. Wharton K, Derynck R. PMID: 19855012.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    46. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J Biol Chem. 2009 Nov 13; 284(46):31690-703. Piscopo DM, Johansen EB, Derynck R. PMID: 19759027.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    47. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug; 19(8):385-94. Kang JS, Liu C, Derynck R. PMID: 19648010.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    48. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36. Liu C, Xu P, Lamouille S, Xu J, Derynck R. PMID: 19595713.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    49. Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Dev Cell. 2009 Jul; 17(1):35-48. Wu L, Derynck R. PMID: 19619490.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    50. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72. Xu J, Lamouille S, Derynck R. PMID: 19153598.
      View in: PubMed   Mentions: 908     Fields:    Translation:Cells
    51. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J. 2009 Jan 21; 28(2):88-98. Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF. PMID: 19096363.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    52. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. J Cell Sci. 2008 Jul 01; 121(Pt 13):2265-74. Imhof I, Gasper WJ, Derynck R. PMID: 18544636.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    53. The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nat Cell Biol. 2008 Jun; 10(6):654-64. Kang JS, Saunier EF, Akhurst RJ, Derynck R. PMID: 18469808.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    54. Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One. 2009; 4(4):e5275. Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T. PMID: 19357790.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    55. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol. 2007 Sep; 9(9):1000-4. Derynck R, Akhurst RJ. PMID: 17762890.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    56. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 2007 Sep 05; 26(17):3957-67. Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. PMID: 17673906.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansAnimalsCells
    57. Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 2007 Jul 30; 178(3):437-51. Lamouille S, Derynck R. PMID: 17646396.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansAnimalsCells
    58. Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. J Cell Sci. 2007 Jul 15; 120(Pt 14):2454-66. Castro CP, Piscopo D, Nakagawa T, Derynck R. PMID: 17607000.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    59. Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone. Plast Reconstr Surg. 2006 Sep 15; 118(4):851-861. Wan DC, Aalami OO, Wang Z, Nacamuli RP, Lorget F, Derynck R, Longaker MT. PMID: 16980845.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    60. Smads In Mesenchymal Differentiation. Smad Signal Transduction. 2006 Jan 1; 5:93-112. Rik Derynck, Lisa Choy, Tamara Alliston. .
      View in: Publisher Site   Mentions:
    61. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18813-8. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. PMID: 16354837.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    62. Transforming growth factor-beta signaling in stem cells and cancer. Science. 2005 Oct 07; 310(5745):68-71. Mishra L, Derynck R, Mishra B. PMID: 16210527.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    63. Crystal structure of IRF-3 in complex with CBP. Structure. 2005 Sep; 13(9):1269-77. Qin BY, Liu C, Srinath H, Lam SS, Correia JJ, Derynck R, Lin K. PMID: 16154084.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    64. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug; 233(4):1315-31. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. PMID: 15965977.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    65. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005 Jul 20; 24(14):2543-55. Kang JS, Alliston T, Delston R, Derynck R. PMID: 15990875.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    66. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005 Jun 24; 280(25):24227-37. Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R. PMID: 15849193.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    67. Signalling by TGF-ß. The Cancer Handbook. 2005 Jan 15. Jing Qing, Rik Derynck. .
      View in: Publisher Site   Mentions:
    68. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol. 2005; 21:659-93. Feng XH, Derynck R. PMID: 16212511.
      View in: PubMed   Mentions: 764     Fields:    Translation:HumansAnimalsCells
    69. JNK regulates expression and autocrine signaling of TGF-beta1. Mol Cell. 2004 Jul 23; 15(2):170-1. Pardoux C, Derynck R. PMID: 15260968.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    70. TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 2004 Apr 07; 23(7):1557-66. Liu D, Kang JS, Derynck R. PMID: 15044954.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    71. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol. 2004 Feb; 24(3):1411-25. Qing J, Liu C, Choy L, Wu RY, Pagano JS, Derynck R. PMID: 14729983.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    72. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat Struct Biol. 2003 Nov; 10(11):913-21. Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K. PMID: 14555996.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    73. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003 Oct 09; 425(6958):577-84. Derynck R, Zhang YE. PMID: 14534577.
      View in: PubMed   Mentions: 1780     Fields:    Translation:AnimalsCells
    74. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. J Biol Chem. 2003 Jul 25; 278(30):27853-63. Lee PS, Chang C, Liu D, Derynck R. PMID: 12740389.
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    75. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem. 2003 May 16; 278(20):18617-27. Fan H, Turck CW, Derynck R. PMID: 12621058.
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    76. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem. 2003 Mar 14; 278(11):9609-19. Choy L, Derynck R. PMID: 12524424.
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    77. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol. 2002 Oct 14; 159(1):135-46. Skillington J, Choy L, Derynck R. PMID: 12379805.
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    78. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P. PMID: 12161428.
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    79. Medicine: interfering with bone remodelling. Nature. 2002 Apr 18; 416(6882):686-7. Alliston T, Derynck R. PMID: 11961535.
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    80. TGF-ß signaling in cancer — a double-edged sword. Trends in Cell Biology. 2001 Nov 1; 11:s44-s51. Rosemary J. Akhurst, Rik Derynck. .
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    81. Erratum: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TFG-ß-induced transcription. Nature. 1998 Dec 1; 396(6710):491-491. Ying Zhang, Xin-Hua Feng, Rik Derynck. .
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    82. VGR-1/BMP-6 INDUCES OSTEOGENIC DIFFERENTIATION IN MESEN-CHYMAL CELLS. Pediatric Research. 1993 May 1; 33(Suppl 5):s82-s82. S E Gitelman, M Kirk, A J Kahn, R Derynck. .
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    83. THE ROLE OF TGF-ß FAMILY MEMBERS IN MESENCHYMAL DIFFERENTIATION. Pediatric Research. 1993 May 1; 33(Suppl 5):s9-s10. Rik Derynck, Ellen Filvaroff, Adrian Erlebacher, Stephen Gitelman. .
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    84. Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms. Molecular and Cellular Biology. 1992 Apr 1; 12(4):1674-1679. A R Lopez, J Cook, P L Deininger, R Derynck. .
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    85. Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region. Molecular and Cellular Biology. 1991 Sep 1; 11(9):4306-4313. B A Arrick, A L Lee, R L Grendell, R Derynck. .
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    86. Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Molecular and Cellular Biology. 1989 Dec 1; 9(12):5508-5515. C C Bascom, J R Wolfshohl, R J Coffey, L Madisen, N R Webb, A R Purchio, R Derynck, H L Moses. .
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    87. 4742003 Human transforming growth factor. Progress in Growth Factor Research. 1989 Jan 1; 1(4):281. Rik M Derynck, David Goeddel. .
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    88. The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. Molecular and Cellular Biology. 1988 Dec 1; 8(12):5549-5554. E B Jakobovits, U Schlokat, J L Vannice, R Derynck, A D Levinson. .
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    89. Developmental expression of transforming growth factors alpha and beta in mouse fetus. Molecular and Cellular Biology. 1988 Aug 1; 8(8):3415-3422. J N Wilcox, R Derynck. .
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    90. Transforming Growth Factor-a. Oncogenes and Growth Control. 1986 Jan 1; 58-64. Rik Derynck. .
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    91. CHAPTER 13 Expression of Human Interferon-? in Heterologous Systems Genentech, Inc. Contribution no. 134. Experimental Manipulation of Gene Expression. 1983 Jan 1; 247-258. RIK DERYNCK, RONALD A. HITZEMAN, PATRICK W. GRAY, DAVID V. GOEDDEL. .
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    92. SYNTHESIS OF HUMAN INTERFERONS AND ANALOGS IN HETEROLOGOUS CELLS. From Gene to Protein: Translation Into Biotechnology. 1982 Jan 1; 249-262. R. Derynck, P.W. Gray, E. Yelverton, D.W. Leung, H.M. Shepard, R.M. Lawn, A. Ullrich, R. Najarian, D. Pennica, F.E. Hagie, R.A. Hitzeman, P.J. Sherwood, A.D. Levinson, D.V. Goeddel. .
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    93. PLASMID-DIRECTED SYNTHESIS OF HUMAN IMMUNE INTERFERON IN E. COLI AND MONKEY CELLS. Interferons. 1982 Jan 1; 1-14. Christian C. Simonsen, H. Michael Shepard, Patrick W. Gray, David W. Leung, Diane Pennica, Elizabeth Yelverton, Rik Derynck, Pamela J. Sherwood, Arthur D. Levinson, David V. Goeddel. .
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