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Rik Derynck, PhD

Title(s)Professor Emeritus, Cell and Tissue Biology
SchoolSchool of Dentistry
Phone415-476-7322
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    Collapse Research 
    Collapse Research Activities and Funding
    Central role of ShcA in differential TGF-beta signaling, epithelial plasticity and carcinoma cell behavior
    NIH/NCI R01CA198179Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    TGF-b family signaling in cardiomyocyte differentiation from embryonic stem cells
    NIH/NHLBI R21HL092394Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Regulatory non-Smad signaling in TGF-b-induced epithelial-mesenchymal transition
    NIH/NCI R01CA136690Jan 1, 2009 - Dec 31, 2018
    Role: Principal Investigator
    Conversion of pre-adipose cells into muscle cells
    NIH/NIAMS R21AR054746Jul 15, 2008 - Mar 31, 2011
    Role: Principal Investigator
    TGF-beta receptor sumoylation and cell behavior
    NIH/NCI R21CA125190Dec 14, 2006 - Nov 30, 2008
    Role: Principal Investigator
    TGF-Beta Superfamily: Signaling and Development
    NIH/NICHD R13HD044643Jul 12, 2003 - Jul 11, 2004
    Role: Principal Investigator
    FASEB CONFERENCE ON TGF-BETA SUPERFAMILY
    NIH/NICHD R13HD040990Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    ADHESION AND PROLIFERATION IN ORAL CANCER PROGRESSION
    NIH/NIDCR P01DE013904Jun 1, 2001 - May 31, 2008
    Role: Co-Investigator
    NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    NIH/NIDCR P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    Molecular Basis of Lung Morphogenesis Injury &Repair
    NIH/NHLBI P01HL060231Apr 1, 1998 - Mar 31, 2011
    Role: Co-Investigator
    Functional crosstalk of TGF-beta/Smad signaling with methyl transferases
    NIH/NCI R01CA063101Jan 1, 1995 - Jan 31, 2015
    Role: Principal Investigator
    TGF-BETA FAMILY AND BONE AND CARTILAGE FORMATION
    NIH/NIAMS R01AR041126May 1, 1993 - Apr 30, 1998
    Role: Principal Investigator
    ADHESION AND REMODELING MECHANISMS IN GINGIVA AND BONE
    NIH/NIDCR P50DE010306Dec 1, 1992 - Oct 31, 1999
    Role: Co-Investigator
    ROLE OF THE TGF-B FAMILY IN BONE AND CARTILAGE FORMATION
    NIH/NIAMS R55AR041126Sep 1, 1992 - Apr 30, 1993
    Role: Principal Investigator
    FUNCTION OF TRANSMEMBRANE TGF A ASSOCIATED PROTEINS
    NIH/NCI R01CA054826Apr 8, 1992 - Dec 31, 2005
    Role: Principal Investigator
    CONFERENCE ON GROWTH AND DIFFERENTIATION FACTORS
    NIH/NIGMS R13GM047154Mar 1, 1992 - Feb 28, 1993
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Budi EH, Mamai O, Hoffman S, Akhurst RJ, Derynck R. Enhanced TGF-ß Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells. iScience. 2019 Jan 25; 11:474-491. PMID: 30684493.
      View in: PubMed
    2. Katsuno Y, Qin J, Oses-Prieto J, Wang H, Jackson-Weaver O, Zhang T, Lamouille S, Wu J, Burlingame A, Xu J, Derynck R. Arginine methylation of SMAD7 by PRMT1 in TGF-ß-induced epithelial-mesenchymal transition and epithelial stem-cell generation. J Biol Chem. 2018 Aug 24; 293(34):13059-13072. PMID: 29907569.
      View in: PubMed
    3. Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R. Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition. EMBO Rep. 2018 01; 19(1):135-155. PMID: 29233829.
      View in: PubMed
    4. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. PMID: 28872461.
      View in: PubMed
    5. Budi EH, Duan D, Derynck R. Transforming Growth Factor-ß Receptors and Smads: Regulatory Complexity and Functional Versatility. Trends Cell Biol. 2017 09; 27(9):658-672. PMID: 28552280.
      View in: PubMed
    6. Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12478-12483. PMID: 27738243.
      View in: PubMed
    7. Moses HL, Roberts AB, Derynck R. The Discovery and Early Days of TGF-ß: A Historical Perspective. Cold Spring Harb Perspect Biol. 2016 07 01; 8(7). PMID: 27328871.
      View in: PubMed
    8. Morikawa M, Derynck R, Miyazono K. TGF-ß and the TGF-ß Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5). PMID: 27141051.
      View in: PubMed
    9. Budi EH, Xu J, Derynck R. Regulation of TGF-ß Receptors. Methods Mol Biol. 2016; 1344:1-33. PMID: 26520115.
      View in: PubMed
    10. Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R. ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-ß-Induced Smad Activation. PLoS Biol. 2015 Dec; 13(12):e1002325. PMID: 26680585; PMCID: PMC4682977.
    11. Budi EH, Muthusamy BP, Derynck R. The insulin response integrates increased TGF-ß signaling through Akt-induced enhancement of cell surface delivery of TGF-ß receptors. Sci Signal. 2015 Sep 29; 8(396):ra96. PMID: 26420907; PMCID: PMC4669960.
    12. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. PMID: 25526531; PMCID: PMC4273650 [Available on 12/18/15].
    13. Derynck R, Muthusamy BP, Saeteurn KY. Signaling pathway cooperation in TGF-ß-induced epithelial-mesenchymal transition. Curr Opin Cell Biol. 2014 Dec; 31:56-66. PMID: 25240174; PMCID: PMC4657734.
    14. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. Pillars Article: production of transforming growth factor ß by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050. J Immunol. 2014 Apr 01; 192(7):2939-52. PMID: 24659787.
      View in: PubMed
    15. Xu J, Derynck R. Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014; 13(8):1209-10. PMID: 24621505; PMCID: PMC4049950.
    16. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96. PMID: 24556840; PMCID: PMC4240281.
    17. Derynck R, Akhurst RJ. BMP-9 balances endothelial cell fate. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18746-7. PMID: 24222686; PMCID: PMC3839760.
    18. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19. PMID: 23747011; PMCID: PMC3951972.
    19. Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013 Jun 21; 288(25):18546-60. PMID: 23649632; PMCID: PMC3689995.
    20. Lamouille S, Subramanyam D, Blelloch R, Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7. PMID: 23434068; PMCID: PMC4240277.
    21. Katsuno Y, Lamouille S, Derynck R. TGF-ß signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 2013 Jan; 25(1):76-84. PMID: 23197193.
      View in: PubMed
    22. Sakaki-Yumoto M, Katsuno Y, Derynck R. TGF-ß family signaling in stem cells. Biochim Biophys Acta. 2013 Feb; 1830(2):2280-96. PMID: 22959078; PMCID: PMC4240309.
    23. Xu P, Liu J, Derynck R. Post-translational regulation of TGF-ß receptor and Smad signaling. FEBS Lett. 2012 Jul 04; 586(14):1871-84. PMID: 22617150; PMCID: PMC4240271.
    24. Xu P, Liu J, Sakaki-Yumoto M, Derynck R. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci Signal. 2012 May 01; 5(222):ra34. PMID: 22550340; PMCID: PMC4254802.
    25. Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. TGF-ß-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci. 2012 Mar 01; 125(Pt 5):1259-73. PMID: 22399812; PMCID: PMC3324583.
    26. Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7820-5. PMID: 21518866; PMCID: PMC3093514.
    27. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May; 29(5):443-8. PMID: 21490602; PMCID: PMC3685579.
    28. Lamouille S, Derynck R. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-ß-induced epithelial-mesenchymal transition. Cells Tissues Organs. 2011; 193(1-2):8-22. PMID: 21041997; PMCID: PMC3030503.
    29. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71. PMID: 20847738; PMCID: PMC2948188.
    30. Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010 Feb 26; 37(4):551-66. PMID: 20188673; PMCID: PMC4240279.
    31. Lamouille S, Derynck R. Oncogene and tumour suppressor: the two faces of SnoN. EMBO J. 2009 Nov 18; 28(22):3459-60. PMID: 19920850; PMCID: PMC2782103.
    32. Wharton K, Derynck R. TGFbeta family signaling: novel insights in development and disease. Development. 2009 Nov; 136(22):3691-7. PMID: 19855012.
      View in: PubMed
    33. Piscopo DM, Johansen EB, Derynck R. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J Biol Chem. 2009 Nov 13; 284(46):31690-703. PMID: 19759027; PMCID: PMC2797240.
    34. Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug; 19(8):385-94. PMID: 19648010.
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    35. Liu C, Xu P, Lamouille S, Xu J, Derynck R. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36. PMID: 19595713; PMCID: PMC2740991.
    36. Wu L, Derynck R. Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Dev Cell. 2009 Jul; 17(1):35-48. PMID: 19619490; PMCID: PMC2722039.
    37. Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72. PMID: 19153598; PMCID: PMC4720263.
    38. Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J. 2009 Jan 21; 28(2):88-98. PMID: 19096363; PMCID: PMC2634733.
    39. Imhof I, Gasper WJ, Derynck R. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. J Cell Sci. 2008 Jul 01; 121(Pt 13):2265-74. PMID: 18544636.
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    40. Kang JS, Saunier EF, Akhurst RJ, Derynck R. The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nat Cell Biol. 2008 Jun; 10(6):654-64. PMID: 18469808; PMCID: PMC2649123.
    41. Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T. Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One. 2009; 4(4):e5275. PMID: 19357790; PMCID: PMC2666804.
    42. Derynck R, Akhurst RJ. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol. 2007 Sep; 9(9):1000-4. PMID: 17762890.
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    43. Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 2007 Sep 05; 26(17):3957-67. PMID: 17673906; PMCID: PMC1994119.
    44. Lamouille S, Derynck R. Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 2007 Jul 30; 178(3):437-51. PMID: 17646396; PMCID: PMC2064840.
    45. Castro CP, Piscopo D, Nakagawa T, Derynck R. Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. J Cell Sci. 2007 Jul 15; 120(Pt 14):2454-66. PMID: 17607000.
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    46. Wan DC, Aalami OO, Wang Z, Nacamuli RP, Lorget F, Derynck R, Longaker MT. Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone. Plast Reconstr Surg. 2006 Sep 15; 118(4):851-61. PMID: 16980845.
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    47. Habig M, Smola H, Dole VS, Derynck R, Pfister H, Smola-Hess S. E7 proteins from high- and low-risk human papillomaviruses bind to TGF-beta-regulated Smad proteins and inhibit their transcriptional activity. Arch Virol. 2006 Oct; 151(10):1961-72. PMID: 16710631.
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    48. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18813-8. PMID: 16354837; PMCID: PMC1323171.
    49. Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science. 2005 Oct 07; 310(5745):68-71. PMID: 16210527.
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    50. Qin BY, Liu C, Srinath H, Lam SS, Correia JJ, Derynck R, Lin K. Crystal structure of IRF-3 in complex with CBP. Structure. 2005 Sep; 13(9):1269-77. PMID: 16154084.
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    51. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug; 233(4):1315-31. PMID: 15965977.
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    52. Kang JS, Alliston T, Delston R, Derynck R. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005 Jul 20; 24(14):2543-55. PMID: 15990875; PMCID: PMC1176457.
    53. Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005 Jun 24; 280(25):24227-37. PMID: 15849193.
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    54. Feng XH, Derynck R. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol. 2005; 21:659-93. PMID: 16212511.
      View in: PubMed
    55. Pardoux C, Derynck R. JNK regulates expression and autocrine signaling of TGF-beta1. Mol Cell. 2004 Jul 23; 15(2):170-1. PMID: 15260968.
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    56. Liu D, Kang JS, Derynck R. TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 2004 Apr 07; 23(7):1557-66. PMID: 15044954; PMCID: PMC391082.
    57. Qing J, Liu C, Choy L, Wu RY, Pagano JS, Derynck R. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol. 2004 Feb; 24(3):1411-25. PMID: 14729983; PMCID: PMC321430.
    58. Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat Struct Biol. 2003 Nov; 10(11):913-21. PMID: 14555996.
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    59. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003 Oct 09; 425(6958):577-84. PMID: 14534577.
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    60. Lee PS, Chang C, Liu D, Derynck R. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. J Biol Chem. 2003 Jul 25; 278(30):27853-63. PMID: 12740389.
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    61. Fan H, Turck CW, Derynck R. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem. 2003 May 16; 278(20):18617-27. PMID: 12621058.
      View in: PubMed
    62. Choy L, Derynck R. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem. 2003 Mar 14; 278(11):9609-19. PMID: 12524424.
      View in: PubMed
    63. Skillington J, Choy L, Derynck R. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol. 2002 Oct 14; 159(1):135-46. PMID: 12379805; PMCID: PMC2173483.
    64. Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. PMID: 12161428.
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    65. Alliston T, Derynck R. Medicine: interfering with bone remodelling. Nature. 2002 Apr 18; 416(6882):686-7. PMID: 11961535.
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    66. Roberts AB, Derynck R. Meeting report: signaling schemes for TGF-beta. Sci STKE. 2001 Dec 18; 2001(113):pe43. PMID: 11752631.
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    67. Liu D, Black BL, Derynck R. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 2001 Nov 15; 15(22):2950-66. PMID: 11711431; PMCID: PMC312830.
    68. Akhurst RJ, Derynck R. TGF-beta signaling in cancer--a double-edged sword. Trends Cell Biol. 2001 Nov; 11(11):S44-51. PMID: 11684442.
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    69. Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 2001 Oct; 29(2):117-29. PMID: 11586292.
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    70. Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia. 2001 Jul-Aug; 3(4):339-50. PMID: 11571634; PMCID: PMC1505868.
    71. Alliston T, Choy L, Ducy P, Karsenty G, Derynck R. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 2001 May 01; 20(9):2254-72. PMID: 11331591; PMCID: PMC125448.
    72. Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):974-9. PMID: 11158580; PMCID: PMC14694.
    73. Feng XH, Derynck R. Mammalian two-hybrid assays. Analyzing protein-protein interactions in transforming growth factor-beta signaling pathway. Methods Mol Biol. 2001; 177:221-39. PMID: 11530609.
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    74. Qing J, Zhang Y, Derynck R. Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity. J Biol Chem. 2000 Dec 08; 275(49):38802-12. PMID: 10995748.
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    75. Patil S, Wildey GM, Brown TL, Choy L, Derynck R, Howe PH. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. J Biol Chem. 2000 Dec 08; 275(49):38363-70. PMID: 10995749.
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    76. Kuo A, Zhong C, Lane WS, Derynck R. Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55. EMBO J. 2000 Dec 01; 19(23):6427-39. PMID: 11101516; PMCID: PMC305863.
    77. Feng XH, Lin X, Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J. 2000 Oct 02; 19(19):5178-93. PMID: 11013220; PMCID: PMC302105.
    78. Zhang Y, Derynck R. Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members. J Biol Chem. 2000 Jun 02; 275(22):16979-85. PMID: 10748032.
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    79. Choy L, Skillington J, Derynck R. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol. 2000 May 01; 149(3):667-82. PMID: 10791980; PMCID: PMC2174852.
    80. Shi W, Fan H, Shum L, Derynck R. The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation. J Cell Biol. 2000 Feb 07; 148(3):591-602. PMID: 10662783; PMCID: PMC2174814.
    81. Fan H, Derynck R. Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J. 1999 Dec 15; 18(24):6962-72. PMID: 10601018; PMCID: PMC1171759.
    82. Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999 Oct; 126(19):4267-79. PMID: 10477295.
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    83. Kornblum HI, Zurcher SD, Werb Z, Derynck R, Seroogy KB. Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system. Eur J Neurosci. 1999 Sep; 11(9):3236-46. PMID: 10510187.
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    84. Zhang Y, Derynck R. Regulation of Smad signalling by protein associations and signalling crosstalk. Trends Cell Biol. 1999 Jul; 9(7):274-9. PMID: 10370243.
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    85. Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler CF, Derynck R, Werb Z. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nat Genet. 1999 May; 22(1):69-73. PMID: 10319864.
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    86. Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-beta responses. Cell. 1998 Dec 11; 95(6):737-40. PMID: 9865691.
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    87. Choy L, Derynck R. The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response. J Biol Chem. 1998 Nov 20; 273(47):31455-62. PMID: 9813058.
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    88. Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R. Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. Mol Cell Biol. 1998 Nov; 18(11):6595-604. PMID: 9774674; PMCID: PMC109244.
    89. Filvaroff E, Derynck R. Bone remodelling: a signalling system for osteoclast regulation. Curr Biol. 1998 Sep 24; 8(19):R679-82. PMID: 9768352.
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    90. Sebastian J, Richards RG, Walker MP, Wiesen JF, Werb Z, Derynck R, Hom YK, Cunha GR, DiAugustine RP. Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis. Cell Growth Differ. 1998 Sep; 9(9):777-85. PMID: 9751121.
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    91. Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998 Aug 27; 394(6696):909-13. PMID: 9732876.
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    92. Feng XH, Zhang Y, Wu RY, Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 1998 Jul 15; 12(14):2153-63. PMID: 9679060; PMCID: PMC317015.
    93. Erlebacher A, Filvaroff EH, Ye JQ, Derynck R. Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell. 1998 Jul; 9(7):1903-18. PMID: 9658179; PMCID: PMC25433.
    94. Derynck R. SMAD proteins and mammalian anatomy. Nature. 1998 Jun 25; 393(6687):737-9. PMID: 9655387.
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    95. Gorska AE, Joseph H, Derynck R, Moses HL, Serra R. Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ. 1998 Mar; 9(3):229-38. PMID: 9543389.
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    96. Hom YK, Young P, Wiesen JF, Miettinen PJ, Derynck R, Werb Z, Cunha GR. Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. Endocrinology. 1998 Mar; 139(3):913-21. PMID: 9492020.
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    97. Verlhac MH, Chen RH, Hanachi P, Hershey JW, Derynck R. Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation. EMBO J. 1997 Nov 17; 16(22):6812-22. PMID: 9362495; PMCID: PMC1170285.
    98. Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW. Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development. 1997 Nov; 124(22):4467-80. PMID: 9409665.
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    99. Derynck R, Feng XH. TGF-beta receptor signaling. Biochim Biophys Acta. 1997 Oct 24; 1333(2):F105-50. PMID: 9395284.
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    100. Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, Moses HL. Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol. 1997 Oct 20; 139(2):541-52. PMID: 9334355.
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    101. Feng XH, Derynck R. A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. EMBO J. 1997 Jul 01; 16(13):3912-23. PMID: 9233801; PMCID: PMC1170015.
    102. Miettinen PJ, Warburton D, Bu D, Zhao JS, Berger JE, Minoo P, Koivisto T, Allen L, Dobbs L, Werb Z, Derynck R. Impaired lung branching morphogenesis in the absence of functional EGF receptor. Dev Biol. 1997 Jun 15; 186(2):224-36. PMID: 9205141.
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    103. Lawler S, Feng XH, Chen RH, Maruoka EM, Turck CW, Griswold-Prenner I, Derynck R. The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues. J Biol Chem. 1997 Jun 06; 272(23):14850-9. PMID: 9169454.
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    104. Wu RY, Zhang Y, Feng XH, Derynck R. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol. 1997 May; 17(5):2521-8. PMID: 9111321; PMCID: PMC232101.
    105. Zhang Y, Musci T, Derynck R. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr Biol. 1997 Apr 01; 7(4):270-6. PMID: 9094310.
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    106. Wang XJ, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR. Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2386-91. PMID: 9122204; PMCID: PMC20097.
    107. Gitelman SE, Kobrin M, Lee A, Fet V, Lyons K, Hogan BL, Derynck R. Structure and sequence of the mouse Bmp6 gene. Mamm Genome. 1997 Mar; 8(3):212-4. PMID: 9069123.
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    108. Shum L, Turck CW, Derynck R. Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association. J Biol Chem. 1996 Nov 08; 271(45):28502-8. PMID: 8910478.
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    109. Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, Massagué J, Melton DA, Mlodzik M, Padgett RW, Roberts AB, Smith J, Thomsen GH, Vogelstein B, Wang XF. Nomenclature: vertebrate mediators of TGFbeta family signals. Cell. 1996 Oct 18; 87(2):173. PMID: 8861901.
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    110. Derynck R, Zhang Y. Intracellular signalling: the mad way to do it. Curr Biol. 1996 Oct 01; 6(10):1226-9. PMID: 8939556.
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    111. Filvaroff EH, Derynck R. Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation. Dev Biol. 1996 Sep 15; 178(2):459-71. PMID: 8812142.
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    112. Zhang Y, Feng X, We R, Derynck R. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 1996 Sep 12; 383(6596):168-72. PMID: 8774881.
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    113. Feng XH, Derynck R. Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. J Biol Chem. 1996 May 31; 271(22):13123-9. PMID: 8662796.
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    114. Erlebacher A, Derynck R. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996 Jan; 132(1-2):195-210. PMID: 8567723; PMCID: PMC2120709.
    115. Feng XH, Filvaroff EH, Derynck R. Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors. J Biol Chem. 1995 Oct 13; 270(41):24237-45. PMID: 7592630.
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    116. Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. Nature. 1995 Oct 12; 377(6549):548-52. PMID: 7566156.
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    117. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 1995 Jul 27; 376(6538):337-41. PMID: 7630400.
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    118. Gitelman SE, Kirk M, Ye JQ, Filvaroff EH, Kahn AJ, Derynck R. Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. Cell Growth Differ. 1995 Jul; 6(7):827-36. PMID: 7547504.
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    119. Chen RH, Moses HL, Maruoka EM, Derynck R, Kawabata M. Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors. J Biol Chem. 1995 May 19; 270(20):12235-41. PMID: 7744874.
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    120. Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R. Toward a molecular understanding of skeletal development. Cell. 1995 Feb 10; 80(3):371-8. PMID: 7859279.
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    121. Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol. 1994 Dec; 127(6 Pt 2):2021-36. PMID: 7806579; PMCID: PMC2120317.
    122. Derynck R. TGF-beta-receptor-mediated signaling. Trends Biochem Sci. 1994 Dec; 19(12):548-53. PMID: 7846768.
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    123. Chen RH, Derynck R. Homomeric interactions between type II transforming growth factor-beta receptors. J Biol Chem. 1994 Sep 09; 269(36):22868-74. PMID: 7521335.
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    124. Gitelman SE, Kobrin MS, Ye JQ, Lopez AR, Lee A, Derynck R. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol. 1994 Sep; 126(6):1595-609. PMID: 8089189; PMCID: PMC2290953.
    125. Filvaroff EH, Ebner R, Derynck R. Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor. Development. 1994 May; 120(5):1085-95. PMID: 8026322.
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    126. Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R. Association of the transmembrane TGF-alpha precursor with a protein kinase complex. J Cell Biol. 1994 May; 125(4):903-16. PMID: 8188754; PMCID: PMC2120079.
    127. Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA. Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest. 1994 Feb; 93(2):892-9. PMID: 8113421; PMCID: PMC293960.
    128. Derynck R, Chen RH, Ebner R, Filvaroff EH, Lawler S. An emerging complexity of receptors for transforming growth factor-beta. Princess Takamatsu Symp. 1994; 24:264-75. PMID: 8983081.
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    129. Lawler S, Candia AF, Ebner R, Shum L, Lopez AR, Moses HL, Wright CV, Derynck R. The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1. Development. 1994 Jan; 120(1):165-75. PMID: 8119124.
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    130. Nabel EG, Shum L, Pompili VJ, Yang ZY, San H, Shu HB, Liptay S, Gold L, Gordon D, Derynck R. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10759-63. PMID: 8248168; PMCID: PMC47857.
    131. Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R. Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. Science. 1993 Nov 05; 262(5135):900-2. PMID: 8235612.
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    132. Chang HL, Gillett N, Figari I, Lopez AR, Palladino MA, Derynck R. Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. Cancer Res. 1993 Sep 15; 53(18):4391-8. PMID: 8364935.
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    133. Ebner R, Chen RH, Shum L, Lawler S, Zioncheck TF, Lee A, Lopez AR, Derynck R. Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science. 1993 May 28; 260(5112):1344-8. PMID: 8388127.
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    134. Chen RH, Ebner R, Derynck R. Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. Science. 1993 May 28; 260(5112):1335-8. PMID: 8388126.
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    135. Gazit D, Ebner R, Kahn AJ, Derynck R. Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Mol Endocrinol. 1993 Feb; 7(2):189-98. PMID: 8385738.
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    136. Streuli CH, Schmidhauser C, Kobrin M, Bissell MJ, Derynck R. Extracellular matrix regulates expression of the TGF-beta 1 gene. J Cell Biol. 1993 Jan; 120(1):253-60. PMID: 8416992; PMCID: PMC2119480.
    137. Arrick BA, Lopez AR, Elfman F, Ebner R, Damsky CH, Derynck R. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1. J Cell Biol. 1992 Aug; 118(3):715-26. PMID: 1639853; PMCID: PMC2289543.
    138. Lopez AR, Cook J, Deininger PL, Derynck R. Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms. Mol Cell Biol. 1992 Apr; 12(4):1674-9. PMID: 1549120; PMCID: PMC369610.
    139. Arrick BA, Derynck R. Growth regulation by transforming growth factor-beta. Cancer Treat Res. 1992; 63:255-64. PMID: 1363360.
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    140. Derynck R. The physiology of transforming growth factor-alpha. Adv Cancer Res. 1992; 58:27-52. PMID: 1546559.
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    141. Lyons RM, Miller DA, Graycar JL, Moses HL, Derynck R. Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors. Mol Endocrinol. 1991 Dec; 5(12):1887-96. PMID: 1665203.
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    142. Arrick BA, Lee AL, Grendell RL, Derynck R. Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region. Mol Cell Biol. 1991 Sep; 11(9):4306-13. PMID: 1875922; PMCID: PMC361291.
    143. Ebner R, Derynck R. Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul. 1991 Aug; 2(8):599-612. PMID: 1777504.
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    144. Lucas C, Bringman TS, Derynck R. Generation of antibodies and assays for transforming growth factor alpha. Methods Enzymol. 1991; 198:185-91. PMID: 1857217.
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    145. Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, Srimal S. Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol. 1990 Aug 01; 145(3):940-4. PMID: 2115549.
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    146. Arrick BA, Korc M, Derynck R. Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol. Cancer Res. 1990 Jan 15; 50(2):299-303. PMID: 2295070.
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    147. Miller DA, Pelton RW, Derynck R, Moses HL. Transforming growth factor-beta. A family of growth regulatory peptides. Ann N Y Acad Sci. 1990; 593:208-17. PMID: 2375595.
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    148. Miller DA, Lee A, Matsui Y, Chen EY, Moses HL, Derynck R. Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues. Mol Endocrinol. 1989 Dec; 3(12):1926-34. PMID: 2628730.
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    149. Bascom CC, Wolfshohl JR, Coffey RJ, Madisen L, Webb NR, Purchio AR, Derynck R, Moses HL. Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol Cell Biol. 1989 Dec; 9(12):5508-15. PMID: 2586525; PMCID: PMC363721.
    150. Graycar JL, Miller DA, Arrick BA, Lyons RM, Moses HL, Derynck R. Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2. Mol Endocrinol. 1989 Dec; 3(12):1977-86. PMID: 2628733.
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    151. Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R. Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos. Mol Endocrinol. 1989 Jul; 3(7):1108-14. PMID: 2797004.
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    152. Wen DZ, Rowland A, Derynck R. Expression and secretion of gro/MGSA by stimulated human endothelial cells. EMBO J. 1989 Jun; 8(6):1761-6. PMID: 2670560; PMCID: PMC401020.
    153. Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BL, Derynck R. Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4554-8. PMID: 2734307; PMCID: PMC287309.
    154. Brachmann R, Lindquist PB, Nagashima M, Kohr W, Lipari T, Napier M, Derynck R. Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. Cell. 1989 Feb 24; 56(4):691-700. PMID: 2645058.
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    155. Shankar V, Ciardiello F, Kim N, Derynck R, Liscia DS, Merlo G, Langton BC, Sheer D, Callahan R, Bassin RH. Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA. Mol Carcinog. 1989; 2(1):1-11. PMID: 2786419.
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    156. Jakobovits EB, Schlokat U, Vannice JL, Derynck R, Levinson AD. The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. Mol Cell Biol. 1988 Dec; 8(12):5549-54. PMID: 2907605; PMCID: PMC365660.
    157. Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ. A new type of transforming growth factor-beta, TGF-beta 3. EMBO J. 1988 Dec 01; 7(12):3737-43. PMID: 3208746; PMCID: PMC454948.
    158. Wilcox JN, Derynck R. Developmental expression of transforming growth factors alpha and beta in mouse fetus. Mol Cell Biol. 1988 Aug; 8(8):3415-22. PMID: 3211146; PMCID: PMC363578.
    159. Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul; 7(7):2025-33. PMID: 2970963; PMCID: PMC454478.
    160. Wilcox JN, Derynck R. Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain. J Neurosci. 1988 Jun; 8(6):1901-4. PMID: 2455024.
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    161. Finzi E, Kilkenny A, Strickland JE, Balaschak M, Bringman T, Derynck R, Aaronson S, Yuspa SH. TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression. Mol Carcinog. 1988; 1(1):7-12. PMID: 2475136.
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    162. Gutierrez GE, Mundy GR, Derynck R, Hewlett EL, Katz MS. Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor. J Biol Chem. 1987 Nov 25; 262(33):15845-50. PMID: 3500168.
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    163. Smith JJ, Derynck R, Korc M. Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle. Proc Natl Acad Sci U S A. 1987 Nov; 84(21):7567-70. PMID: 3499610; PMCID: PMC299340.
    164. Liu SC, Sanfilippo B, Perroteau I, Derynck R, Salomon DS, Kidwell WR. Expression of transforming growth factor alpha (TGF alpha) in differentiated rat mammary tumors: estrogen induction of TGF alpha production. Mol Endocrinol. 1987 Oct; 1(10):683-92. PMID: 2484711.
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    165. Coffey RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR. Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature. 1987 Aug 27-Sep 2; 328(6133):817-20. PMID: 2442615.
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    166. Finzi E, Fleming T, Segatto O, Pennington CY, Bringman TS, Derynck R, Aaronson SA. The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells. Proc Natl Acad Sci U S A. 1987 Jun; 84(11):3733-7. PMID: 3035551; PMCID: PMC304950.
    167. Derynck R, Rhee L, Chen EY, Van Tilburg A. Intron-exon structure of the human transforming growth factor-beta precursor gene. Nucleic Acids Res. 1987 Apr 10; 15(7):3188-9. PMID: 3470709; PMCID: PMC340929.
    168. Derynck R, Rhee L. Sequence of the porcine transforming growth factor-beta precursor. Nucleic Acids Res. 1987 Apr 10; 15(7):3187. PMID: 3470708; PMCID: PMC340928.
    169. Salomon DS, Perroteau I, Kidwell WR, Tam J, Derynck R. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. J Cell Physiol. 1987 Mar; 130(3):397-409. PMID: 3494020.
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    170. Knabbe C, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynck R, Dickson RB. Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell. 1987 Feb 13; 48(3):417-28. PMID: 2879636.
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    171. Derynck R, Goeddel DV, Ullrich A, Gutterman JU, Williams RD, Bringman TS, Berger WH. Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors. Cancer Res. 1987 Feb 01; 47(3):707-12. PMID: 3467839.
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    172. Tashjian AH, Voelkel EF, Lloyd W, Derynck R, Winkler ME, Levine L. Actions of growth factors on plasma calcium. Epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice. J Clin Invest. 1986 Nov; 78(5):1405-9. PMID: 3490496; PMCID: PMC423847.
    173. Takahashi N, MacDonald BR, Hon J, Winkler ME, Derynck R, Mundy GR, Roodman GD. Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures. J Clin Invest. 1986 Oct; 78(4):894-8. PMID: 3489738; PMCID: PMC423711.
    174. Rosenthal A, Lindquist PB, Bringman TS, Goeddel DV, Derynck R. Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation. Cell. 1986 Jul 18; 46(2):301-9. PMID: 3459590.
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    175. Schreiber AB, Winkler ME, Derynck R. Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science. 1986 Jun 06; 232(4755):1250-3. PMID: 2422759.
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    176. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986 May 01; 163(5):1037-50. PMID: 2871125; PMCID: PMC2188095.
    177. Derynck R, Jarrett JA, Chen EY, Goeddel DV. The murine transforming growth factor-beta precursor. J Biol Chem. 1986 Apr 05; 261(10):4377-9. PMID: 3007454.
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    178. Derynck R, Rosenthal A, Lindquist PB, Bringman TS, Goeddel DV. Endogenous and heterologous expression of transforming growth factor-alpha in mammalian cells. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:649-55. PMID: 3472744.
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    179. Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ. Human transforming growth factor-alpha stimulates bone resorption in vitro. J Clin Invest. 1985 Nov; 76(5):2016-9. PMID: 3877079; PMCID: PMC424268.
    180. Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature. 1985 Aug 22-28; 316(6030):701-5. PMID: 3861940.
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    181. Tashjian AH, Voelkel EF, Lazzaro M, Singer FR, Roberts AB, Derynck R, Winkler ME, Levine L. Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc Natl Acad Sci U S A. 1985 Jul; 82(13):4535-8. PMID: 3859875; PMCID: PMC391137.
    182. Smith JM, Sporn MB, Roberts AB, Derynck R, Winkler ME, Gregory H. Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice. Nature. 1985 Jun 6-12; 315(6019):515-6. PMID: 3873618.
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    183. Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature. 1984 Dec 20-1985 Jan 2; 312(5996):724-9. PMID: 6392892.
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    184. Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV. Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell. 1984 Aug; 38(1):287-97. PMID: 6088071.
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