Rik Derynck, PhD

Title(s)Professor, Cell and Tissue Biology
SchoolSchool of Dentistry
Address35 Medical Center Way
San Francisco CA 94143
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    Central role of ShcA in differential TGF-beta signaling, epithelial plasticity and carcinoma cell behavior
    NIH R01CA198179Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    TGF-b family signaling in cardiomyocyte differentiation from embryonic stem cells
    NIH R21HL092394Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Regulatory non-Smad signaling in TGF-b-induced epithelial-mesenchymal transition
    NIH R01CA136690Jan 1, 2009 - Dec 31, 2019
    Role: Principal Investigator
    Conversion of pre-adipose cells into muscle cells
    NIH R21AR054746Jul 15, 2008 - Mar 31, 2011
    Role: Principal Investigator
    TGF-beta receptor sumoylation and cell behavior
    NIH R21CA125190Dec 14, 2006 - Nov 30, 2008
    Role: Principal Investigator
    TGF-Beta Superfamily: Signaling and Development
    NIH R13HD044643Jul 12, 2003 - Jul 11, 2004
    Role: Principal Investigator
    NIH R13HD040990Jul 1, 2001 - Jun 30, 2002
    Role: Principal Investigator
    NIH P01DE013904Jun 1, 2001 - May 31, 2008
    Role: Co-Investigator
    NIH P60DE013058Aug 1, 1999 - Jul 31, 2006
    Role: Co-Investigator
    Molecular Basis of Lung Morphogenesis Injury &Repair
    NIH P01HL060231Apr 1, 1998 - Mar 31, 2011
    Role: Co-Investigator
    Functional crosstalk of TGF-beta/Smad signaling with methyl transferases
    NIH R01CA063101Jan 1, 1995 - Dec 31, 2009
    Role: Principal Investigator
    NIH R01AR041126May 1, 1993 - Apr 30, 1998
    Role: Principal Investigator
    NIH P50DE010306Dec 1, 1992 - Nov 30, 1997
    Role: Co-Investigator
    NIH R55AR041126Sep 1, 1992 - Apr 30, 1993
    Role: Principal Investigator
    NIH R01CA054826Apr 8, 1992 - Dec 31, 2005
    Role: Principal Investigator
    NIH R13GM047154Mar 1, 1992 - Feb 28, 1993
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TGF-ß as a driver of fibrosis: physiological roles and therapeutic opportunities. J Pathol. 2021 Apr 08. PMID: 33834494.
      View in: PubMed   Mentions:    Fields:    
    2. Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-ß family. Dev Cell. 2021 Mar 22; 56(6):726-746. Katsuno Y, Derynck R. PMID: 33756119.
      View in: PubMed   Mentions:    Fields:    
    3. TGFß biology in cancer progression and immunotherapy. Nat Rev Clin Oncol. 2021 Jan; 18(1):9-34. Derynck R, Turley SJ, Akhurst RJ. PMID: 32710082.
      View in: PubMed   Mentions: 4     Fields:    
    4. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020 06; 21(6):341-352. Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RJY, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G. PMID: 32300252.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    5. Integration of TGF-ß-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells. Sci Rep. 2019 11 18; 9(1):16992. Budi EH, Hoffman S, Gao S, Zhang YE, Derynck R. PMID: 31740700.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. EMT and Cancer: More Than Meets the Eye. Dev Cell. 2019 05 06; 49(3):313-316. Derynck R, Weinberg RA. PMID: 31063750.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    7. Transforming growth factor-ß (TGF-ß)-induced up-regulation of TGF-ß receptors at the cell surface amplifies the TGF-ß response. J Biol Chem. 2019 05 24; 294(21):8490-8504. Duan D, Derynck R. PMID: 30948511.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Specificity, versatility, and control of TGF-ß family signaling. Sci Signal. 2019 02 26; 12(570). Derynck R, Budi EH. PMID: 30808818.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    9. Chronic TGF-ß exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Sci Signal. 2019 02 26; 12(570). Katsuno Y, Meyer DS, Zhang Z, Shokat KM, Akhurst RJ, Miyazono K, Derynck R. PMID: 30808819.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    10. Enhanced TGF-ß Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells. iScience. 2019 Jan 25; 11:474-491. Budi EH, Mamai O, Hoffman S, Akhurst RJ, Derynck R. PMID: 30684493.
      View in: PubMed   Mentions:
    11. Arginine methylation of SMAD7 by PRMT1 in TGF-ß-induced epithelial-mesenchymal transition and epithelial stem-cell generation. J Biol Chem. 2018 08 24; 293(34):13059-13072. Katsuno Y, Qin J, Oses-Prieto J, Wang H, Jackson-Weaver O, Zhang T, Lamouille S, Wu J, Burlingame A, Xu J, Derynck R. PMID: 29907569.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition. . 2018 01; 19(1):135-155. Du D, Katsuno Y, Meyer D, Budi EH, Chen SH, Koeppen H, Wang H, Akhurst RJ, Derynck R. PMID: 29233829.
      View in: PubMed   Mentions:
    13. Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. PMID: 28872461.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    14. Transforming Growth Factor-ß Receptors and Smads: Regulatory Complexity and Functional Versatility. Trends Cell Biol. 2017 09; 27(9):658-672. Budi EH, Duan D, Derynck R. PMID: 28552280.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    15. Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12478-12483. Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K. PMID: 27738243.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. The Discovery and Early Days of TGF-ß: A Historical Perspective. Cold Spring Harb Perspect Biol. 2016 07 01; 8(7). Moses HL, Roberts AB, Derynck R. PMID: 27328871.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    17. TGF-ß and the TGF-ß Family: Context-Dependent Roles in Cell and Tissue Physiology. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5). Morikawa M, Derynck R, Miyazono K. PMID: 27141051.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    18. Regulation of TGF-ß Receptors. Methods Mol Biol. 2016; 1344:1-33. Budi EH, Xu J, Derynck R. PMID: 26520115.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-ß-Induced Smad Activation. PLoS Biol. 2015 Dec; 13(12):e1002325. Muthusamy BP, Budi EH, Katsuno Y, Lee MK, Smith SM, Mirza AM, Akhurst RJ, Derynck R. PMID: 26680585.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. The insulin response integrates increased TGF-ß signaling through Akt-induced enhancement of cell surface delivery of TGF-ß receptors. Sci Signal. 2015 Sep 29; 8(396):ra96. Budi EH, Muthusamy BP, Derynck R. PMID: 26420907.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. PMID: 25526531.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    22. Signaling pathway cooperation in TGF-ß-induced epithelial-mesenchymal transition. Curr Opin Cell Biol. 2014 Dec; 31:56-66. Derynck R, Muthusamy BP, Saeteurn KY. PMID: 25240174.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    23. Pillars Article: production of transforming growth factor ß by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050. J Immunol. 2014 Apr 01; 192(7):2939-52. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. PMID: 24659787.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Does Smad6 methylation control BMP signaling in cancer? . 2014; 13(8):1209-10. Xu J, Derynck R. PMID: 24621505.
      View in: PubMed   Mentions:
    25. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96. Lamouille S, Xu J, Derynck R. PMID: 24556840.
      View in: PubMed   Mentions: 1898     Fields:    Translation:HumansCells
    26. BMP-9 balances endothelial cell fate. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18746-7. Derynck R, Akhurst RJ. PMID: 24222686.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. S-1 Complexity of cytokines in Treg function and stability. Cytokine. 2013 Sep 1; 63(3):241. Jeffrey A. Bluestone, Samantha Bailey-Bucktrout, Pinglong Xu, Rik Derynck, Elenora Trotta, Natasha Crellins, Isaac Rondon, Michael DuPage, Mark Travis, Dean Sheppard. .
      View in: Publisher Site   Mentions:
    28. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. PMID: 23747011.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    29. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem. 2013 Jun 21; 288(25):18546-60. Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R. PMID: 23649632.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    30. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol. 2013 Apr; 25(2):200-7. Lamouille S, Subramanyam D, Blelloch R, Derynck R. PMID: 23434068.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    31. TGF-ß signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 2013 Jan; 25(1):76-84. Katsuno Y, Lamouille S, Derynck R. PMID: 23197193.
      View in: PubMed   Mentions: 285     Fields:    Translation:HumansAnimalsCells
    32. 578 High Content Analysis of the Epithelial-Mesenchymal Transition to Identify Novel Targets in Cancer Progression. European Journal of Cancer. 2012 Nov 1; 48:177. S. Lamouille, R. Judson, R. Blelloch, R. Derynck. .
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    33. TGF-ß family signaling in stem cells. Biochim Biophys Acta. 2013 Feb; 1830(2):2280-96. Sakaki-Yumoto M, Katsuno Y, Derynck R. PMID: 22959078.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    34. Post-translational regulation of TGF-ß receptor and Smad signaling. FEBS Lett. 2012 Jul 04; 586(14):1871-84. Xu P, Liu J, Derynck R. PMID: 22617150.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    35. TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. Development. 2012 May 15; 139(10):e1008-e1008. S. Lamouille, E. Connolly, J. W. Smyth, R. J. Akhurst, R. Derynck. .
      View in: Publisher Site   Mentions:
    36. TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Sci Signal. 2012 May 01; 5(222):ra34. Xu P, Liu J, Sakaki-Yumoto M, Derynck R. PMID: 22550340.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    37. TGF-ß-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci. 2012 Mar 01; 125(Pt 5):1259-73. Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. PMID: 22399812.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    38. Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-beta signaling. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7820-5. Upadhyay G, Yin Y, Yuan H, Li X, Derynck R, Glazer RI. PMID: 21518866.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    39. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011 May; 29(5):443-8. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. PMID: 21490602.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansCells
    40. Stem cell antigen-1 (Sca-1) disrupts GDF10/TGF-ß signal transduction at the plasma membrane to regulate Smad2/3 nuclear signaling. The FASEB Journal. 2011 Apr 1; 25:243.5-243.5. Geeta Upadhyay, Yuzhi Yin, Hongyan Yuan, Levy Kopelovich, Rik Derynck, Robert I. Glazer. .
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    41. Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-ß-induced epithelial-mesenchymal transition. Cells Tissues Organs. 2011; 193(1-2):8-22. Lamouille S, Derynck R. PMID: 21041997.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    42. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-ß and Runx2 in bone is required for hearing. . 2010 Oct; 11(10):765-71. Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. PMID: 20847738.
      View in: PubMed   Mentions:
    43. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010 Feb 26; 37(4):551-66. Xu P, Derynck R. PMID: 20188673.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    44. Oncogene and tumour suppressor: the two faces of SnoN. EMBO J. 2009 Nov 18; 28(22):3459-60. Lamouille S, Derynck R. PMID: 19920850.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    45. TGFbeta family signaling: novel insights in development and disease. Development. 2009 Nov; 136(22):3691-7. Wharton K, Derynck R. PMID: 19855012.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    46. Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J Biol Chem. 2009 Nov 13; 284(46):31690-703. Piscopo DM, Johansen EB, Derynck R. PMID: 19759027.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    47. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol. 2009 Aug; 19(8):385-94. Kang JS, Liu C, Derynck R. PMID: 19648010.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    48. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36. Liu C, Xu P, Lamouille S, Xu J, Derynck R. PMID: 19595713.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    49. Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Dev Cell. 2009 Jul; 17(1):35-48. Wu L, Derynck R. PMID: 19619490.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    50. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72. Xu J, Lamouille S, Derynck R. PMID: 19153598.
      View in: PubMed   Mentions: 793     Fields:    Translation:Cells
    51. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J. 2009 Jan 21; 28(2):88-98. Liu IM, Schilling SH, Knouse KA, Choy L, Derynck R, Wang XF. PMID: 19096363.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    52. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. J Cell Sci. 2008 Jul 01; 121(Pt 13):2265-74. Imhof I, Gasper WJ, Derynck R. PMID: 18544636.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    53. The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nat Cell Biol. 2008 Jun; 10(6):654-64. Kang JS, Saunier EF, Akhurst RJ, Derynck R. PMID: 18469808.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    54. Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone. PLoS One. 2009; 4(4):e5275. Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T. PMID: 19357790.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    55. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol. 2007 Sep; 9(9):1000-4. Derynck R, Akhurst RJ. PMID: 17762890.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    56. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 2007 Sep 05; 26(17):3957-67. Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. PMID: 17673906.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimalsCells
    57. Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 2007 Jul 30; 178(3):437-51. Lamouille S, Derynck R. PMID: 17646396.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimalsCells
    58. Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. J Cell Sci. 2007 Jul 15; 120(Pt 14):2454-66. Castro CP, Piscopo D, Nakagawa T, Derynck R. PMID: 17607000.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    59. Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone. Plast Reconstr Surg. 2006 Sep 15; 118(4):851-861. Wan DC, Aalami OO, Wang Z, Nacamuli RP, Lorget F, Derynck R, Longaker MT. PMID: 16980845.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    60. E7 proteins from high- and low-risk human papillomaviruses bind to TGF-beta-regulated Smad proteins and inhibit their transcriptional activity. Arch Virol. 2006 Oct; 151(10):1961-72. Habig M, Smola H, Dole VS, Derynck R, Pfister H, Smola-Hess S. PMID: 16710631.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    61. Smads In Mesenchymal Differentiation. Smad Signal Transduction. 2006 Jan 1; 5:93-112. Rik Derynck, Lisa Choy, Tamara Alliston. .
      View in: Publisher Site   Mentions:
    62. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18813-8. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. PMID: 16354837.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    63. Transforming growth factor-beta signaling in stem cells and cancer. Science. 2005 Oct 07; 310(5745):68-71. Mishra L, Derynck R, Mishra B. PMID: 16210527.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    64. Crystal structure of IRF-3 in complex with CBP. Structure. 2005 Sep; 13(9):1269-77. Qin BY, Liu C, Srinath H, Lam SS, Correia JJ, Derynck R, Lin K. PMID: 16154084.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    65. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug; 233(4):1315-31. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. PMID: 15965977.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    66. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005 Jul 20; 24(14):2543-55. Kang JS, Alliston T, Delston R, Derynck R. PMID: 15990875.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    67. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005 Jun 24; 280(25):24227-37. Alliston T, Ko TC, Cao Y, Liang YY, Feng XH, Chang C, Derynck R. PMID: 15849193.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    68. Signalling by TGF-ß. The Cancer Handbook. 2005 Jan 15. Jing Qing, Rik Derynck. .
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    69. Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol. 2005; 21:659-93. Feng XH, Derynck R. PMID: 16212511.
      View in: PubMed   Mentions: 722     Fields:    Translation:HumansAnimalsCells
    70. JNK regulates expression and autocrine signaling of TGF-beta1. Mol Cell. 2004 Jul 23; 15(2):170-1. Pardoux C, Derynck R. PMID: 15260968.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    71. TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 2004 Apr 07; 23(7):1557-66. Liu D, Kang JS, Derynck R. PMID: 15044954.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    72. Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol. 2004 Feb; 24(3):1411-25. Qing J, Liu C, Choy L, Wu RY, Pagano JS, Derynck R. PMID: 14729983.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    73. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat Struct Biol. 2003 Nov; 10(11):913-21. Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K. PMID: 14555996.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    74. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003 Oct 09; 425(6958):577-84. Derynck R, Zhang YE. PMID: 14534577.
      View in: PubMed   Mentions: 1640     Fields:    Translation:AnimalsCells
    75. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. J Biol Chem. 2003 Jul 25; 278(30):27853-63. Lee PS, Chang C, Liu D, Derynck R. PMID: 12740389.
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    76. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem. 2003 May 16; 278(20):18617-27. Fan H, Turck CW, Derynck R. PMID: 12621058.
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    77. Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem. 2003 Mar 14; 278(11):9609-19. Choy L, Derynck R. PMID: 12524424.
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    78. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol. 2002 Oct 14; 159(1):135-46. Skillington J, Choy L, Derynck R. PMID: 12379805.
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    79. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P. PMID: 12161428.
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    80. Medicine: interfering with bone remodelling. Nature. 2002 Apr 18; 416(6882):686-7. Alliston T, Derynck R. PMID: 11961535.
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    81. Meeting report: signaling schemes for TGF-beta. Sci STKE. 2001 Dec 18; 2001(113):pe43. Roberts AB, Derynck R. PMID: 11752631.
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    82. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 2001 Nov 15; 15(22):2950-66. Liu D, Black BL, Derynck R. PMID: 11711431.
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    83. TGF-beta signaling in cancer--a double-edged sword. Trends Cell Biol. 2001 Nov; 11(11):S44-51. Akhurst RJ, Derynck R. PMID: 11684442.
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    84. TGF-ß signaling in cancer — a double-edged sword. Trends in Cell Biology. 2001 Nov 1; 11:s44-s51. Rosemary J. Akhurst, Rik Derynck. .
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    85. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 2001 Oct; 29(2):117-29. Derynck R, Akhurst RJ, Balmain A. PMID: 11586292.
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    86. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia. 2001 Jul-Aug; 3(4):339-50. Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen JF, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT. PMID: 11571634.
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    87. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 2001 May 01; 20(9):2254-72. Alliston T, Choy L, Ducy P, Karsenty G, Derynck R. PMID: 11331591.
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    88. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):974-9. Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R. PMID: 11158580.
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    89. Mammalian two-hybrid assays. Analyzing protein-protein interactions in transforming growth factor-beta signaling pathway. Methods Mol Biol. 2001; 177:221-39. Feng XH, Derynck R. PMID: 11530609.
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    90. Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity. J Biol Chem. 2000 Dec 08; 275(49):38802-12. Qing J, Zhang Y, Derynck R. PMID: 10995748.
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    91. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. J Biol Chem. 2000 Dec 08; 275(49):38363-70. Patil S, Wildey GM, Brown TL, Choy L, Derynck R, Howe PH. PMID: 10995749.
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    92. Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55. EMBO J. 2000 Dec 01; 19(23):6427-39. Kuo A, Zhong C, Lane WS, Derynck R. PMID: 11101516.
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    93. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J. 2000 Oct 02; 19(19):5178-93. Feng XH, Lin X, Derynck R. PMID: 11013220.
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    94. Transcriptional regulation of the transforming growth factor-beta -inducible mouse germ line Ig alpha constant region gene by functional cooperation of Smad, CREB, and AML family members. J Biol Chem. 2000 Jun 02; 275(22):16979-85. Zhang Y, Derynck R. PMID: 10748032.
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    95. Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol. 2000 May 01; 149(3):667-82. Choy L, Skillington J, Derynck R. PMID: 10791980.
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    96. The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation. J Cell Biol. 2000 Feb 07; 148(3):591-602. Shi W, Fan H, Shum L, Derynck R. PMID: 10662783.
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    97. Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J. 1999 Dec 15; 18(24):6962-72. Fan H, Derynck R. PMID: 10601018.
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    98. Skeletal development in the zebrafish. Nat Genet. 1999 Dec; 23(4):379. Derynck R. PMID: 10581014.
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    99. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass. Development. 1999 Oct; 126(19):4267-79. Filvaroff E, Erlebacher A, Ye J, Gitelman SE, Lotz J, Heillman M, Derynck R. PMID: 10477295.
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    100. Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system. Eur J Neurosci. 1999 Sep; 11(9):3236-46. Kornblum HI, Zurcher SD, Werb Z, Derynck R, Seroogy KB. PMID: 10510187.
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    101. Regulation of Smad signalling by protein associations and signalling crosstalk. Trends Cell Biol. 1999 Jul; 9(7):274-9. Zhang Y, Derynck R. PMID: 10370243.
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    102. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Nat Genet. 1999 May; 22(1):69-73. Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler CF, Derynck R, Werb Z. PMID: 10319864.
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    103. Smads: transcriptional activators of TGF-beta responses. Cell. 1998 Dec 11; 95(6):737-40. Derynck R, Zhang Y, Feng XH. PMID: 9865691.
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    104. Erratum: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TFG-ß-induced transcription. Nature. 1998 Dec 1; 396(6710):491-491. Ying Zhang, Xin-Hua Feng, Rik Derynck. .
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    105. The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response. J Biol Chem. 1998 Nov 20; 273(47):31455-62. Choy L, Derynck R. PMID: 9813058.
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    106. Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. Mol Cell Biol. 1998 Nov; 18(11):6595-604. Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R. PMID: 9774674.
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    107. Bone remodelling: a signalling system for osteoclast regulation. Curr Biol. 1998 Sep 24; 8(19):R679-82. Filvaroff E, Derynck R. PMID: 9768352.
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    108. Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor. J Neurosci Res. 1998 Sep 15; 53(6):697-717. Kornblum HI, Hussain R, Wiesen J, Miettinen P, Zurcher SD, Chow K, Derynck R, Werb Z. PMID: 9753198.
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    109. Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis. Cell Growth Differ. 1998 Sep; 9(9):777-85. Sebastian J, Richards RG, Walker MP, Wiesen JF, Werb Z, Derynck R, Hom YK, Cunha GR, DiAugustine RP. PMID: 9751121.
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    110. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998 Aug 27; 394(6696):909-13. Zhang Y, Feng XH, Derynck R. PMID: 9732876.
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    111. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 1998 Jul 15; 12(14):2153-63. Feng XH, Zhang Y, Wu RY, Derynck R. PMID: 9679060.
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    112. Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell. 1998 Jul; 9(7):1903-18. Erlebacher A, Filvaroff EH, Ye JQ, Derynck R. PMID: 9658179.
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    113. SMAD proteins and mammalian anatomy. Nature. 1998 Jun 25; 393(6687):737-9. Derynck R. PMID: 9655387.
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    114. Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ. 1998 Mar; 9(3):229-38. Gorska AE, Joseph H, Derynck R, Moses HL, Serra R. PMID: 9543389.
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    115. Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. Endocrinology. 1998 Mar; 139(3):913-21. Hom YK, Young P, Wiesen JF, Miettinen PJ, Derynck R, Werb Z, Cunha GR. PMID: 9492020.
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    116. Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation. EMBO J. 1997 Nov 17; 16(22):6812-22. Verlhac MH, Chen RH, Hanachi P, Hershey JW, Derynck R. PMID: 9362495.
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    117. Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development. 1997 Nov; 124(22):4467-80. Candia AF, Watabe T, Hawley SH, Onichtchouk D, Zhang Y, Derynck R, Niehrs C, Cho KW. PMID: 9409665.
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    118. TGF-beta receptor signaling. Biochim Biophys Acta. 1997 Oct 24; 1333(2):F105-50. Derynck R, Feng XH. PMID: 9395284.
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    119. Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol. 1997 Oct 20; 139(2):541-52. Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, Moses HL. PMID: 9334355.
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    120. A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. EMBO J. 1997 Jul 01; 16(13):3912-23. Feng XH, Derynck R. PMID: 9233801.
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    121. Impaired lung branching morphogenesis in the absence of functional EGF receptor. Dev Biol. 1997 Jun 15; 186(2):224-36. Miettinen PJ, Warburton D, Bu D, Zhao JS, Berger JE, Minoo P, Koivisto T, Allen L, Dobbs L, Werb Z, Derynck R. PMID: 9205141.
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    122. The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues. J Biol Chem. 1997 Jun 06; 272(23):14850-9. Lawler S, Feng XH, Chen RH, Maruoka EM, Turck CW, Griswold-Prenner I, Derynck R. PMID: 9169454.
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    123. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol. 1997 May; 17(5):2521-8. Wu RY, Zhang Y, Feng XH, Derynck R. PMID: 9111321.
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    124. The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function. Curr Biol. 1997 Apr 01; 7(4):270-6. Zhang Y, Musci T, Derynck R. PMID: 9094310.
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    125. Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2386-91. Wang XJ, Greenhalgh DA, Bickenbach JR, Jiang A, Bundman DS, Krieg T, Derynck R, Roop DR. PMID: 9122204.
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    126. Structure and sequence of the mouse Bmp6 gene. Mamm Genome. 1997 Mar; 8(3):212-4. Gitelman SE, Kobrin M, Lee A, Fet V, Lyons K, Hogan BL, Derynck R. PMID: 9069123.
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    127. Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association. J Biol Chem. 1996 Nov 08; 271(45):28502-8. Shum L, Turck CW, Derynck R. PMID: 8910478.
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    128. Nomenclature: vertebrate mediators of TGFbeta family signals. Cell. 1996 Oct 18; 87(2):173. Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, Massagué J, Melton DA, Mlodzik M, Padgett RW, Roberts AB, Smith J, Thomsen GH, Vogelstein B, Wang XF. PMID: 8861901.
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    129. Intracellular signalling: the mad way to do it. Curr Biol. 1996 Oct 01; 6(10):1226-9. Derynck R, Zhang Y. PMID: 8939556.
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    130. Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation. Dev Biol. 1996 Sep 15; 178(2):459-71. Filvaroff EH, Derynck R. PMID: 8812142.
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    131. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 1996 Sep 12; 383(6596):168-72. Zhang Y, Feng X, We R, Derynck R. PMID: 8774881.
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    132. Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. J Biol Chem. 1996 May 31; 271(22):13123-9. Feng XH, Derynck R. PMID: 8662796.
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    133. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 1996 Jan; 132(1-2):195-210. Erlebacher A, Derynck R. PMID: 8567723.
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    134. Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors. J Biol Chem. 1995 Oct 13; 270(41):24237-45. Feng XH, Filvaroff EH, Derynck R. PMID: 7592630.
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    135. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. Nature. 1995 Oct 12; 377(6549):548-52. Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R. PMID: 7566156.
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    136. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 1995 Jul 27; 376(6538):337-41. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. PMID: 7630400.
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    137. Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells. Cell Growth Differ. 1995 Jul; 6(7):827-36. Gitelman SE, Kirk M, Ye JQ, Filvaroff EH, Kahn AJ, Derynck R. PMID: 7547504.
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    138. Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors. J Biol Chem. 1995 May 19; 270(20):12235-41. Chen RH, Moses HL, Maruoka EM, Derynck R, Kawabata M. PMID: 7744874.
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    139. Toward a molecular understanding of skeletal development. Cell. 1995 Feb 10; 80(3):371-8. Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R. PMID: 7859279.
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    140. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol. 1994 Dec; 127(6 Pt 2):2021-36. Miettinen PJ, Ebner R, Lopez AR, Derynck R. PMID: 7806579.
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    141. TGF-beta-receptor-mediated signaling. Trends Biochem Sci. 1994 Dec; 19(12):548-53. Derynck R. PMID: 7846768.
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    142. Homomeric interactions between type II transforming growth factor-beta receptors. J Biol Chem. 1994 Sep 09; 269(36):22868-74. Chen RH, Derynck R. PMID: 7521335.
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    143. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol. 1994 Sep; 126(6):1595-609. Gitelman SE, Kobrin MS, Ye JQ, Lopez AR, Lee A, Derynck R. PMID: 8089189.
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    144. Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor. Development. 1994 May; 120(5):1085-95. Filvaroff EH, Ebner R, Derynck R. PMID: 8026322.
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    145. Association of the transmembrane TGF-alpha precursor with a protein kinase complex. J Cell Biol. 1994 May; 125(4):903-16. Shum L, Reeves SA, Kuo AC, Fromer ES, Derynck R. PMID: 8188754.
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    146. Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest. 1994 Feb; 93(2):892-9. Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA. PMID: 8113421.
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    147. An emerging complexity of receptors for transforming growth factor-beta. Princess Takamatsu Symp. 1994; 24:264-75. Derynck R, Chen RH, Ebner R, Filvaroff EH, Lawler S. PMID: 8983081.
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    148. The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1. Development. 1994 Jan; 120(1):165-75. Lawler S, Candia AF, Ebner R, Shum L, Lopez AR, Moses HL, Wright CV, Derynck R. PMID: 8119124.
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    149. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10759-63. Nabel EG, Shum L, Pompili VJ, Yang ZY, San H, Shu HB, Liptay S, Gold L, Gordon D, Derynck R. PMID: 8248168.
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    150. Determination of type I receptor specificity by the type II receptors for TGF-beta or activin. Science. 1993 Nov 05; 262(5135):900-2. Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R. PMID: 8235612.
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    151. Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. Cancer Res. 1993 Sep 15; 53(18):4391-8. Chang HL, Gillett N, Figari I, Lopez AR, Palladino MA, Derynck R. PMID: 8364935.
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    152. Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. Cell Growth Differ. 1993 Jun; 4(6):513-21. Pittelkow MR, Cook PW, Shipley GD, Derynck R, Coffey RJ. PMID: 8373735.
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    153. Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor. Science. 1993 May 28; 260(5112):1344-8. Ebner R, Chen RH, Shum L, Lawler S, Zioncheck TF, Lee A, Lopez AR, Derynck R. PMID: 8388127.
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    154. Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. Science. 1993 May 28; 260(5112):1335-8. Chen RH, Ebner R, Derynck R. PMID: 8388126.
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    155. VGR-1/BMP-6 INDUCES OSTEOGENIC DIFFERENTIATION IN MESEN-CHYMAL CELLS. Pediatric Research. 1993 May 1; 33(Suppl 5):s82-s82. S E Gitelman, M Kirk, A J Kahn, R Derynck. .
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    157. Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Mol Endocrinol. 1993 Feb; 7(2):189-98. Gazit D, Ebner R, Kahn AJ, Derynck R. PMID: 8385738.
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    158. Extracellular matrix regulates expression of the TGF-beta 1 gene. J Cell Biol. 1993 Jan; 120(1):253-60. Streuli CH, Schmidhauser C, Kobrin M, Bissell MJ, Derynck R. PMID: 8416992.
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    159. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1. J Cell Biol. 1992 Aug; 118(3):715-26. Arrick BA, Lopez AR, Elfman F, Ebner R, Damsky CH, Derynck R. PMID: 1639853.
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    160. Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms. Mol Cell Biol. 1992 Apr; 12(4):1674-9. Lopez AR, Cook J, Deininger PL, Derynck R. PMID: 1549120.
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    161. Growth regulation by transforming growth factor-beta. Cancer Treat Res. 1992; 63:255-64. Arrick BA, Derynck R. PMID: 1363360.
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    162. The physiology of transforming growth factor-alpha. Adv Cancer Res. 1992; 58:27-52. Derynck R. PMID: 1546559.
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    163. Differential binding of transforming growth factor-beta 1, -beta 2, and -beta 3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors. Mol Endocrinol. 1991 Dec; 5(12):1887-96. Lyons RM, Miller DA, Graycar JL, Moses HL, Derynck R. PMID: 1665203.
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    164. Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region. Mol Cell Biol. 1991 Sep; 11(9):4306-13. Arrick BA, Lee AL, Grendell RL, Derynck R. PMID: 1875922.
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    165. Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul. 1991 Aug; 2(8):599-612. Ebner R, Derynck R. PMID: 1777504.
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    166. Effects of MGSA/GRO alpha on melanocyte transformation. Oncogene. 1991 Jul; 6(7):1115-24. Balentien E, Mufson BE, Shattuck RL, Derynck R, Richmond A. PMID: 1861861.
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    167. Generation of antibodies and assays for transforming growth factor alpha. Methods Enzymol. 1991; 198:185-91. Lucas C, Bringman TS, Derynck R. PMID: 1857217.
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    168. Purification and characterization of recombinant melanoma growth stimulating activity. Methods Enzymol. 1991; 198:373-83. Thomas HG, Han JH, Balentien E, Derynck R, Bordoni R, Richmond A. PMID: 1857230.
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    169. Transforming growth factor-alpha. Mol Reprod Dev. 1990 Sep; 27(1):3-9. Derynck R. PMID: 2271184.
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    170. Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol. 1990 Aug 01; 145(3):940-4. Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, Srimal S. PMID: 2115549.
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    171. Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol. Cancer Res. 1990 Jan 15; 50(2):299-303. Arrick BA, Korc M, Derynck R. PMID: 2295070.
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    172. Transforming growth factor-beta. A family of growth regulatory peptides. Ann N Y Acad Sci. 1990; 593:208-17. Miller DA, Pelton RW, Derynck R, Moses HL. PMID: 2375595.
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    173. Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol Cell Biol. 1989 Dec; 9(12):5508-15. Bascom CC, Wolfshohl JR, Coffey RJ, Madisen L, Webb NR, Purchio AR, Derynck R, Moses HL. PMID: 2586525.
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    174. Complementary DNA cloning of the murine transforming growth factor-beta 3 (TGF beta 3) precursor and the comparative expression of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and adult tissues. Mol Endocrinol. 1989 Dec; 3(12):1926-34. Miller DA, Lee A, Matsui Y, Chen EY, Moses HL, Derynck R. PMID: 2628730.
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    175. Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2. Mol Endocrinol. 1989 Dec; 3(12):1977-86. Graycar JL, Miller DA, Arrick BA, Lyons RM, Moses HL, Derynck R. PMID: 2628733.
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    176. Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos. Mol Endocrinol. 1989 Jul; 3(7):1108-14. Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R. PMID: 2797004.
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    177. Expression and secretion of gro/MGSA by stimulated human endothelial cells. EMBO J. 1989 Jun; 8(6):1761-6. Wen DZ, Rowland A, Derynck R. PMID: 2670560.
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    178. Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4554-8. Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BL, Derynck R. PMID: 2734307.
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    179. Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters. J Biol Chem. 1989 Mar 25; 264(9):5164-71. Pittelkow MR, Lindquist PB, Abraham RT, Graves-Deal R, Derynck R, Coffey RJ. PMID: 2925687.
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    180. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem. 1989 Mar 05; 264(7):4133-7. Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R, Stiles CD. PMID: 2917992.
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    181. Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. Cell. 1989 Feb 24; 56(4):691-700. Brachmann R, Lindquist PB, Nagashima M, Kohr W, Lipari T, Napier M, Derynck R. PMID: 2645058.
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    182. Overexpression of transforming growth factor alpha in psoriatic epidermis. Science. 1989 Feb 10; 243(4892):811-4. Elder JT, Fisher GJ, Lindquist PB, Bennett GL, Pittelkow MR, Coffey RJ, Ellingsworth L, Derynck R, Voorhees JJ. PMID: 2916128.
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    183. Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA. Mol Carcinog. 1989; 2(1):1-11. Shankar V, Ciardiello F, Kim N, Derynck R, Liscia DS, Merlo G, Langton BC, Sheer D, Callahan R, Bassin RH. PMID: 2786419.
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    184. Transforming growth factors-alpha and -beta and their potential roles in neoplastic transformation. Cancer Treat Res. 1989; 47:177-95. Derynck R. PMID: 2576997.
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    185. 4742003 Human transforming growth factor. Progress in Growth Factor Research. 1989 Jan 1; 1(4):281. Rik M Derynck, David Goeddel. .
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    186. A new type of transforming growth factor-beta, TGF-beta 3. EMBO J. 1988 Dec 01; 7(12):3737-43. Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ. PMID: 3208746.
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    187. The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. Mol Cell Biol. 1988 Dec; 8(12):5549-54. Jakobovits EB, Schlokat U, Vannice JL, Derynck R, Levinson AD. PMID: 2907605.
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    188. Transforming growth factor alpha. Cell. 1988 Aug 26; 54(5):593-5. Derynck R. PMID: 3044605.
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    189. Developmental expression of transforming growth factors alpha and beta in mouse fetus. Mol Cell Biol. 1988 Aug; 8(8):3415-22. Wilcox JN, Derynck R. PMID: 3211146.
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    190. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul; 7(7):2025-33. Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. PMID: 2970963.
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    191. Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain. J Neurosci. 1988 Jun; 8(6):1901-4. Wilcox JN, Derynck R. PMID: 2455024.
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    192. TGF alpha stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression. Mol Carcinog. 1988; 1(1):7-12. Finzi E, Kilkenny A, Strickland JE, Balaschak M, Bringman T, Derynck R, Aaronson S, Yuspa SH. PMID: 2475136.
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    193. Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988; 3(4):323-31. Barton DE, Foellmer BE, Du J, Tamm J, Derynck R, Francke U. PMID: 3226728.
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    194. Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor. J Biol Chem. 1987 Nov 25; 262(33):15845-50. Gutierrez GE, Mundy GR, Derynck R, Hewlett EL, Katz MS. PMID: 3500168.
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    195. Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle. Proc Natl Acad Sci U S A. 1987 Nov; 84(21):7567-70. Smith JJ, Derynck R, Korc M. PMID: 3499610.
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    196. Expression of transforming growth factor alpha (TGF alpha) in differentiated rat mammary tumors: estrogen induction of TGF alpha production. Mol Endocrinol. 1987 Oct; 1(10):683-92. Liu SC, Sanfilippo B, Perroteau I, Derynck R, Salomon DS, Kidwell WR. PMID: 2484711.
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    197. Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature. 1987 Aug 27-Sep 2; 328(6133):817-20. Coffey RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR. PMID: 2442615.
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    198. Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha. J Pharmacol Exp Ther. 1987 Jul; 242(1):331-7. Gan BS, Hollenberg MD, MacCannell KL, Lederis K, Winkler ME, Derynck R. PMID: 3497258.
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    199. The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells. Proc Natl Acad Sci U S A. 1987 Jun; 84(11):3733-7. Finzi E, Fleming T, Segatto O, Pennington CY, Bringman TS, Derynck R, Aaronson SA. PMID: 3035551.
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    200. Intron-exon structure of the human transforming growth factor-beta precursor gene. Nucleic Acids Res. 1987 Apr 10; 15(7):3188-9. Derynck R, Rhee L, Chen EY, Van Tilburg A. PMID: 3470709.
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    201. Sequence of the porcine transforming growth factor-beta precursor. Nucleic Acids Res. 1987 Apr 10; 15(7):3187. Derynck R, Rhee L. PMID: 3470708.
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    202. Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factors in ras-transformed mouse mammary epithelial cells. J Cell Physiol. 1987 Mar; 130(3):397-409. Salomon DS, Perroteau I, Kidwell WR, Tam J, Derynck R. PMID: 3494020.
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    203. Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursor. Cell. 1987 Feb 13; 48(3):429-40. Bringman TS, Lindquist PB, Derynck R. PMID: 3467848.
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    204. Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell. 1987 Feb 13; 48(3):417-28. Knabbe C, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynck R, Dickson RB. PMID: 2879636.
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    205. Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors. Cancer Res. 1987 Feb 01; 47(3):707-12. Derynck R, Goeddel DV, Ullrich A, Gutterman JU, Williams RD, Bringman TS, Berger WH. PMID: 3467839.
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    206. Actions of growth factors on plasma calcium. Epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice. J Clin Invest. 1986 Nov; 78(5):1405-9. Tashjian AH, Voelkel EF, Lloyd W, Derynck R, Winkler ME, Levine L. PMID: 3490496.
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    207. Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures. J Clin Invest. 1986 Oct; 78(4):894-8. Takahashi N, MacDonald BR, Hon J, Winkler ME, Derynck R, Mundy GR, Roodman GD. PMID: 3489738.
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    208. Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts. Eur J Biochem. 1986 Sep 15; 159(3):625-32. Haegeman G, Content J, Volckaert G, Derynck R, Tavernier J, Fiers W. PMID: 3758081.
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    209. Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation. Cell. 1986 Jul 18; 46(2):301-9. Rosenthal A, Lindquist PB, Bringman TS, Goeddel DV, Derynck R. PMID: 3459590.
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    210. Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science. 1986 Jun 06; 232(4755):1250-3. Schreiber AB, Winkler ME, Derynck R. PMID: 2422759.
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    211. Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somat Cell Mol Genet. 1986 May; 12(3):281-8. Fujii D, Brissenden JE, Derynck R, Francke U. PMID: 3459257.
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    212. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986 May 01; 163(5):1037-50. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. PMID: 2871125.
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    213. The murine transforming growth factor-beta precursor. J Biol Chem. 1986 Apr 05; 261(10):4377-9. Derynck R, Jarrett JA, Chen EY, Goeddel DV. PMID: 3007454.
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    214. Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. Proc Natl Acad Sci U S A. 1986 Apr; 83(7):2228-32. Ibbotson KJ, Harrod J, Gowen M, D'Souza S, Smith DD, Winkler ME, Derynck R, Mundy GR. PMID: 3485799.
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    215. Transforming growth factor-alpha: structure and biological activities. J Cell Biochem. 1986; 32(4):293-304. Derynck R. PMID: 3543030.
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    216. Endogenous and heterologous expression of transforming growth factor-alpha in mammalian cells. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 1:649-55. Derynck R, Rosenthal A, Lindquist PB, Bringman TS, Goeddel DV. PMID: 3472744.
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    217. Transforming Growth Factor-a. Oncogenes and Growth Control. 1986 Jan 1; 58-64. Rik Derynck. .
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    218. Human transforming growth factor-alpha stimulates bone resorption in vitro. J Clin Invest. 1985 Nov; 76(5):2016-9. Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ. PMID: 3877079.
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    219. Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation. Cancer Res. 1985 Nov; 45(11 Pt 2):5593-7. Brissenden JE, Derynck R, Francke U. PMID: 3863708.
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    220. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature. 1985 Aug 22-28; 316(6030):701-5. Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV. PMID: 3861940.
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    221. Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc Natl Acad Sci U S A. 1985 Jul; 82(13):4535-8. Tashjian AH, Voelkel EF, Lazzaro M, Singer FR, Roberts AB, Derynck R, Winkler ME, Levine L. PMID: 3859875.
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    222. Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice. Nature. 1985 Jun 6-12; 315(6019):515-6. Smith JM, Sporn MB, Roberts AB, Derynck R, Winkler ME, Gregory H. PMID: 3873618.
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    223. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature. 1984 Dec 20-1985 Jan 2; 312(5996):724-9. Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, Kohr WJ, Aggarwal BB, Goeddel DV. PMID: 6392892.
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    224. Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell. 1984 Aug; 38(1):287-97. Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV. PMID: 6088071.
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    225. Expression of the human interferon-gamma cDNA in yeast. Nucleic Acids Res. 1983 Mar 25; 11(6):1819-37. Derynck R, Singh A, Goeddel DV. PMID: 6300780.
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    226. CHAPTER 13 Expression of Human Interferon-? in Heterologous Systems Genentech, Inc. Contribution no. 134. Experimental Manipulation of Gene Expression. 1983 Jan 1; 247-258. RIK DERYNCK, RONALD A. HITZEMAN, PATRICK W. GRAY, DAVID V. GOEDDEL. .
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    227. More about interferon cloning. Interferon. 1983; 5:181-203. Derynck R. PMID: 6427115.
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    228. The primary structure of the Saccharomyces cerevisiae gene for 3-phosphoglycerate kinase. Nucleic Acids Res. 1982 Dec 11; 10(23):7791-808. Hitzeman RA, Hagie FE, Hayflick JS, Chen CY, Seeburg PH, Derynck R. PMID: 6296791.
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    229. In vitro cotranslational processing of human pre-interferon beta 1 enhances its biological activity. Virology. 1982 Oct 30; 122(2):466-70. Content J, De Wit L, Derynck R, De Clercq E, Fiers W. PMID: 7147710.
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    230. Human interferon gamma is encoded by a single class of mRNA. Nucleic Acids Res. 1982 Jun 25; 10(12):3605-15. Derynck R, Leung DW, Gray PW, Goeddel DV. PMID: 6180381.
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    231. Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta. Proc Natl Acad Sci U S A. 1982 May; 79(9):2768-72. Content J, De Wit L, Pierard D, Derynck R, De Clercq E, Fiers W. PMID: 6178110.
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    232. Expression of human immune interferon cDNA in E. coli and monkey cells. Nature. 1982 Feb 11; 295(5849):503-8. Gray PW, Leung DW, Pennica D, Yelverton E, Najarian R, Simonsen CC, Derynck R, Sherwood PJ, Wallace DM, Berger SL, Levinson AD, Goeddel DV. PMID: 6173769.
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    233. The human fibroblast interferon gene(s) and their expression in heterologous cells. Princess Takamatsu Symp. 1982; 12:227-36. Fiers W, Degrave W, Derynck R, Devos R, Gheysen D, Remaut E, Stanssens P, Tavernier J, Content J, De Clercq E. PMID: 6762376.
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    234. SYNTHESIS OF HUMAN INTERFERONS AND ANALOGS IN HETEROLOGOUS CELLS. From Gene to Protein: Translation Into Biotechnology. 1982 Jan 1; 249-262. R. Derynck, P.W. Gray, E. Yelverton, D.W. Leung, H.M. Shepard, R.M. Lawn, A. Ullrich, R. Najarian, D. Pennica, F.E. Hagie, R.A. Hitzeman, P.J. Sherwood, A.D. Levinson, D.V. Goeddel. .
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    235. PLASMID-DIRECTED SYNTHESIS OF HUMAN IMMUNE INTERFERON IN E. COLI AND MONKEY CELLS. Interferons. 1982 Jan 1; 1-14. Christian C. Simonsen, H. Michael Shepard, Patrick W. Gray, David W. Leung, Diane Pennica, Elizabeth Yelverton, Rik Derynck, Pamela J. Sherwood, Arthur D. Levinson, David V. Goeddel. .
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    236. Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli. Rev Infect Dis. 1981 Nov-Dec; 3(6):1186-95. Derynck R, Devos R, Remaut E, Saman E, Stanssens P, Tavernier J, Volckaert G, Content J, De Clercq E, Fiers W. PMID: 6177026.
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    237. Molecular mechanisms of nucleotide-sequence rearrangements in cDNA clones of human fibroblast interferon mRNA. Gene. 1981 Nov; 15(2-3):215-23. Volckaert G, Tavernier J, Derynck R, Devos R, Fiers W. PMID: 6170541.
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    238. Nucleotide sequence of the chromosomal gene for human fibroblast (beta 1) interferon and of the flanking regions. Gene. 1981 Aug; 14(3):137-43. Degrave W, Derynck R, Tavernier J, Haegeman G, Fiers W. PMID: 6169589.
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    239. Evidence for a unique human fibroblast interferon (IFN-beta 1) chromosomal gene, devoid of intervening sequences. Nucleic Acids Res. 1981 Feb 11; 9(3):461-71. Tavernier J, Derynck R, Fiers W. PMID: 6164047.
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    240. Expression of human fibroblast interferon gene in Escherichia coli. Nature. 1980 Sep 18; 287(5779):193-7. Derynck R, Remaut E, Saman E, Stanssens P, De Clercq E, Content J, Fiers W. PMID: 6159534.
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    241. Isolation and structure of a human fibroblast interferon gene. Nature. 1980 Jun 19; 285(5766):542-7. Derynck R, Content J, DeClercq E, Volckaert G, Tavernier J, Devos R, Fiers W. PMID: 6157094.
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    242. A two-dimensional electrophoretic procedure for the separation of DNA restriction fragments. J Mol Biol. 1977 Feb 25; 110(2):387-404. Derynck R, Fiers W. PMID: 845955.
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    243. Two dimensional electrophoretic separation of restriction fragments. Arch Int Physiol Biochim. 1977 Feb; 85(1):167-8. Derynck R, Fiers W. PMID: 68729.
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