Cynthia Kenyon, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-476-9864
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    Cynthia Kenyon graduated valedictorian in chemistry and biochemistry from the University of Georgia in 1976. She received her PhD from MIT in 1981, where, in Graham Walker’s laboratory, she was the first to look for genes on the basis of their expression profiles, discovering that DNA damaging agents activate a battery of DNA repair genes in E. coli. She then did postdoctoral studies with Nobel laureate Sydney Brenner at the MRC Laboratory of Molecular Biology in Cambridge, UK, studying the development of C. elegans. Since 1986 she has been at the University of California, San Francisco, where she was the Herbert Boyer Distinguished Professor of Biochemistry and Biophysics and is now an American Cancer Society Professor. In 1993, Kenyon and colleagues’ discovery that a single-gene mutation could double the lifespan of C. elegans sparked an intensive study of the molecular biology of aging. These findings have now led to the discovery that an evolutionarily conserved hormone signaling system controls aging in other organisms as well, including mammals. Dr. Kenyon has received many honors and awards for her findings. She is a member of the US National Academy of Sciences, the American Academy of Arts and Sciences, and the Institute of Medicine and she is a past president of the Genetics Society of America. She is now the director of the Hillblom Center for the Biology of Aging at UCSF.

    Collapse Research 
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    Translational Studies Linking Aging and Cancer
    NIH R01AG044515Sep 30, 2013 - Feb 28, 2019
    Role: Co-Principal Investigator
    Human Gene Knockdowns that May Extend Lifespan
    NIH R01AG041826May 1, 2012 - Apr 30, 2018
    Role: Co-Principal Investigator
    Signals from the reproductive system that regulate aging in C. elegans
    NIH R01AG032435Apr 1, 2009 - Mar 31, 2020
    Role: Co-Principal Investigator
    Lifespan regulation by the DAF-12 nuclear hormone receptor in C. elegans
    NIH R01AG020932Sep 1, 2002 - Aug 31, 2012
    Role: Principal Investigator
    AGING AND NEURODEGENERATIVE DISEASES
    NIH T32AG000278Jun 1, 2002 - Apr 30, 2008
    Role: Principal Investigator
    Genetic Analysis of Aging in C. elegans
    NIH R01AG011816Apr 1, 1994 - Mar 31, 2020
    Role: Co-Principal Investigator
    Genetic Control of Aging in C. elegans
    NIH R37AG011816Apr 1, 1994 - Mar 31, 2014
    Role: Principal Investigator
    ANTERO POSTERIOR PATTERN FORMATION IN C ELEGANS
    NIH R01GM037053Sep 1, 1986 - Aug 31, 2002
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology. Biol Rev Camb Philos Soc. 2021 Sep 03. Buffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño-Enríquez MA, Bronner GN, Coen C, Delaney MA, Dengler-Crish CM, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Lewis Hardell KN, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O'Connor TP, Okanoya K, O'Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos-Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, Smith ESJ. PMID: 34476892.
      View in: PubMed   Mentions:    Fields:    
    2. Split-wrmScarlet and split-sfGFP: tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans. Genetics. 2021 04 15; 217(4). Goudeau J, Sharp CS, Paw J, Savy L, Leonetti MD, York AG, Updike DL, Kenyon C, Ingaramo M. PMID: 33693628.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage. Elife. 2021 04 13; 10. Samaddar M, Goudeau J, Sanchez M, Hall DH, Bohnert KA, Ingaramo M, Kenyon C. PMID: 33848238.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Application of Transcriptional Gene Modules to Analysis of Caenorhabditis elegans' Gene Expression Data. G3 (Bethesda). 2020 10 05; 10(10):3623-3638. Cary M, Podshivalova K, Kenyon C. PMID: 32759329.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Addendum: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage. Nature. 2020 04; 580(7802):E5. Goudeau J, Samaddar M, Bohnert KA, Kenyon C. PMID: 32269336.
      View in: PubMed   Mentions: 2     Fields:    
    6. Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. G3 (Bethesda). 2020 02 06; 10(2):849-862. Zhang P, Zhai Y, Cregg J, Ang KK, Arkin M, Kenyon C. PMID: 31879284.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. Dev Cell. 2019 10 21; 51(2):192-207.e6. Anderson EC, Frankino PA, Higuchi-Sanabria R, Yang Q, Bian Q, Podshivalova K, Shin A, Kenyon C, Dillin A, Meyer BJ. PMID: 31495695.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Containing a measles outbreak in Minnesota, 2017: methods and challenges. Perspect Public Health. 2020 May; 140(3):162-171. Banerjee E, Griffith J, Kenyon C, Christianson B, Strain A, Martin K, McMahon M, Bagstad E, Laine E, Hardy K, Grilli G, Walters J, Dunn D, Roddy M, Ehresmann K. PMID: 31480896.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    9. Sydney Brenner (1927-2019). Science. 2019 May 17; 364(6441):638. Kenyon C. PMID: 31097656.
      View in: PubMed   Mentions: 1     Fields:    
    10. The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired. Genetics. 2018 11; 210(3):999-1009. Chisnell P, Parenteau TR, Tank E, Ashrafi K, Kenyon C. PMID: 30228197.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    11. Silencing the ASI gustatory neuron pair extends lifespan. MicroPubl Biol. 2018 Jun 01; 2018. Chisnell P, Kenyon C. PMID: 32550392.
      View in: PubMed   Mentions:
    12. Silencing the ASI gustatory neuron pair increases expression of the stress-resistance gene sod-3 in a daf-16 and daf-3 independent manner. MicroPubl Biol. 2018 May 30; 2018. Chisnell P, Kenyon C. PMID: 32550378.
      View in: PubMed   Mentions:
    13. A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage. Nature. 2017 11 30; 551(7682):629-633. Bohnert KA, Kenyon C. PMID: 29168500.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    14. How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude. Cell Rep. 2017 04 18; 19(3):441-450. Podshivalova K, Kerr RA, Kenyon C. PMID: 28423308.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    15. Deep Proteome Analysis Identifies Age-Related Processes in C. elegans. Cell Syst. 2016 08; 3(2):144-159. Narayan V, Ly T, Pourkarimi E, Murillo AB, Gartner A, Lamond AI, Kenyon C. PMID: 27453442.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    16. Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans. Cell Metab. 2016 Jun 14; 23(6):1113-1126. Roux AE, Langhans K, Huynh W, Kenyon C. PMID: 27304510.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    17. Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):E2832-41. Wei Y, Kenyon C. PMID: 27140632.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    18. Micro-proteomics with iterative data analysis: Proteome analysis in C. elegans at the single worm level. Proteomics. 2016 Feb; 16(3):381-92. Bensaddek D, Narayan V, Nicolas A, Murillo AB, Gartner A, Kenyon CJ, Lamond AI. PMID: 26552604.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug; 14(4):497-510. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. PMID: 25902704.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansAnimalsCells
    20. A shift to organismal stress resistance in programmed cell death mutants. PLoS Genet. 2013; 9(9):e1003714. Judy ME, Nakamura A, Huang A, Grant H, McCurdy H, Weiberth KF, Gao F, Coppola G, Kenyon C, Kao AW. PMID: 24068943.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    21. The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans. J Cell Sci. 2013 Sep 15; 126(Pt 18):4136-46. Safra M, Ben-Hamo S, Kenyon C, Henis-Korenblit S. PMID: 23843615.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    22. Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab. 2013 Jan 08; 17(1):85-100. Zhang P, Judy M, Lee SJ, Kenyon C. PMID: 23312285.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    23. Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans. PLoS Genet. 2012; 8(12):e1003133. Gaglia MM, Jeong DE, Ryu EA, Lee D, Kenyon C, Lee SJ. PMID: 23284299.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    24. Could a hormone point the way to life extension? Elife. 2012 Oct 15; 1:e00286. Kenyon C. PMID: 23071903.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    25. New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell. 2012 Apr; 11(2):192-202. McCormick M, Chen K, Ramaswamy P, Kenyon C. PMID: 22081913.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    26. The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts. Dev Biol. 2012 Jan 15; 361(2):338-48. Middelkoop TC, Williams L, Yang PT, Luchtenberg J, Betist MC, Ji N, van Oudenaarden A, Kenyon C, Korswagen HC. PMID: 22074987.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    27. QnAs with Cynthia Kenyon. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16875. Kenyon C. PMID: 21969585.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    28. Spontaneous age-related neurite branching in Caenorhabditis elegans. J Neurosci. 2011 Jun 22; 31(25):9279-88. Tank EM, Rodgers KE, Kenyon C. PMID: 21697377.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    29. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4441-6. Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C. PMID: 21368173.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    30. The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12; 366(1561):9-16. Kenyon C. PMID: 21115525.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    31. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity. Mol Cell Endocrinol. 2011 Apr 10; 336(1-2):102-9. Al-Dujaili EA, Kenyon CJ, Nicol MR, Mason JI. PMID: 21184804.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    32. Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Curr Biol. 2010 Dec 07; 20(23):2131-6. Lee SJ, Hwang AB, Kenyon C. PMID: 21093262.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    33. The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol. 2010 Aug 31; 8(8). Yamawaki TM, Berman JR, Suchanek-Kavipurapu M, McCormick M, Gaglia MM, Lee SJ, Kenyon C. PMID: 20824162.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    34. Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol. 2010 Aug 10; 8(8):e1000450. David DC, Ollikainen N, Trinidad JC, Cary MP, Burlingame AL, Kenyon C. PMID: 20711477.
      View in: PubMed   Mentions: 260     Fields:    Translation:HumansAnimals
    35. A pathway that links reproductive status to lifespan in Caenorhabditis elegans. Ann N Y Acad Sci. 2010 Aug; 1204:156-62. Kenyon C. PMID: 20738286.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    36. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9730-5. Henis-Korenblit S, Zhang P, Hansen M, McCormick M, Lee SJ, Cary M, Kenyon C. PMID: 20460307.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    37. The genetics of ageing. Nature. 2010 Mar 25; 464(7288):504-12. Kenyon CJ. PMID: 20336132.
      View in: PubMed   Mentions: 1067     Fields:    Translation:HumansAnimalsCells
    38. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. PMID: 20351400.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 2009 Nov; 10(5):379-91. Lee SJ, Murphy CT, Kenyon C. PMID: 19883616.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    40. A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet. 2009 Sep; 5(9):e1000639. Ghazi A, Henis-Korenblit S, Kenyon C. PMID: 19749979.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    41. Stimulation of movement in a quiescent, hibernation-like form of Caenorhabditis elegans by dopamine signaling. J Neurosci. 2009 Jun 03; 29(22):7302-14. Gaglia MM, Kenyon C. PMID: 19494152.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol. 2009 May 12; 19(9):715-22. Lee SJ, Kenyon C. PMID: 19375320.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    43. A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet. 2009 Apr; 5(4):e1000450. Cristina D, Cary M, Lunceford A, Clarke C, Kenyon C. PMID: 19360127.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    44. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 2008 Feb; 4(2):e24. Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. PMID: 18282106.
      View in: PubMed   Mentions: 297     Fields:    Translation:Animals
    45. Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Genetics. 2008 Jan; 178(1):513-26. Yamawaki TM, Arantes-Oliveira N, Berman JR, Zhang P, Kenyon C. PMID: 18202391.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    46. Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19046-50. Murphy CT, Lee SJ, Kenyon C. PMID: 18025456.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    47. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet. 2007 Nov; 39(11):1403-9. Pinkston-Gosse J, Kenyon C. PMID: 17934462.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    48. Caenorhabditis elegans integrates food and reproductive signals in lifespan determination. Aging Cell. 2007 Oct; 6(5):715-21. Crawford D, Libina N, Kenyon C. PMID: 17711560.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    49. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5947-52. Ghazi A, Henis-Korenblit S, Kenyon C. PMID: 17392428.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    50. A steroid hormone that extends the lifespan of Caenorhabditis elegans. Aging Cell. 2007 Feb; 6(1):87-94. Broué F, Liere P, Kenyon C, Baulieu EE. PMID: 17266678.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    51. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell. 2007 Feb; 6(1):95-110. Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. PMID: 17266679.
      View in: PubMed   Mentions: 374     Fields:    Translation:AnimalsCells
    52. Mutations that increase the life span of C. elegans inhibit tumor growth. Science. 2006 Aug 18; 313(5789):971-5. Pinkston JM, Garigan D, Hansen M, Kenyon C. PMID: 16917064.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    53. Enrichment of regulatory motifs upstream of predicted DAF-16 targets. Nat Genet. 2006 Apr; 38(4):397-8; author reply 398. Kenyon C, Murphy CT. PMID: 16570056.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    54. Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell. 2006 Mar 10; 124(5):1055-68. Berman JR, Kenyon C. PMID: 16530050.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    55. The two isoforms of the Caenorhabditis elegans leukocyte-common antigen related receptor tyrosine phosphatase PTP-3 function independently in axon guidance and synapse formation. J Neurosci. 2005 Aug 17; 25(33):7517-28. Ackley BD, Harrington RJ, Hudson ML, Williams L, Kenyon CJ, Chisholm AD, Jin Y. PMID: 16107639.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    56. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 2005 Jul; 1(1):119-28. Hansen M, Hsu AL, Dillin A, Kenyon C. PMID: 16103914.
      View in: PubMed   Mentions: 222     Fields:    
    57. The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development. Development. 2005 Mar; 132(6):1413-28. Yang L, Sym M, Kenyon C. PMID: 15750187.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    58. The plasticity of aging: insights from long-lived mutants. Cell. 2005 Feb 25; 120(4):449-60. Kenyon C. PMID: 15734678.
      View in: PubMed   Mentions: 477     Fields:    Translation:AnimalsCells
    59. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet. 2004 Feb; 36(2):197-204. McCarroll SA, Murphy CT, Zou S, Pletcher SD, Chin CS, Jan YN, Kenyon C, Bargmann CI, Li H. PMID: 14730301.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimals
    60. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron. 2004 Jan 08; 41(1):45-55. Alcedo J, Kenyon C. PMID: 14715134.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    61. My adventures with genes from the fountain of youth. Harvey Lect. 2004-2005; 100:29-70. Kenyon C. PMID: 16970174.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    62. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell. 2003 Nov 14; 115(4):489-502. Libina N, Berman JR, Kenyon C. PMID: 14622602.
      View in: PubMed   Mentions: 339     Fields:    Translation:AnimalsCells
    63. Healthy animals with extreme longevity. Science. 2003 Oct 24; 302(5645):611. Arantes-Oliveira N, Berman JR, Kenyon C. PMID: 14576426.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    64. Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Genetics. 2003 Aug; 164(4):1355-67. Ch'ng Q, Williams L, Lie YS, Sym M, Whangbo J, Kenyon C. PMID: 12930745.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    65. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003 Jul 17; 424(6946):277-83. Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. PMID: 12845331.
      View in: PubMed   Mentions: 820     Fields:    Translation:AnimalsCells
    66. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 2003 May 16; 300(5622):1142-5. Hsu AL, Murphy CT, Kenyon C. PMID: 12750521.
      View in: PubMed   Mentions: 568     Fields:    Translation:Animals
    67. Rates of behavior and aging specified by mitochondrial function during development. Science. 2002 Dec 20; 298(5602):2398-401. Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C. PMID: 12471266.
      View in: PubMed   Mentions: 389     Fields:    Translation:AnimalsCells
    68. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science. 2002 Oct 25; 298(5594):830-4. Dillin A, Crawford DK, Kenyon C. PMID: 12399591.
      View in: PubMed   Mentions: 175     Fields:    Translation:AnimalsCells
    69. The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Development. 2002 Jul; 129(14):3335-48. Alper S, Kenyon C. PMID: 12091304.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    70. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics. 2002 Jul; 161(3):1101-12. Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C. PMID: 12136014.
      View in: PubMed   Mentions: 291     Fields:    Translation:AnimalsCells
    71. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science. 2002 Jan 18; 295(5554):502-5. Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C. PMID: 11799246.
      View in: PubMed   Mentions: 192     Fields:    Translation:AnimalsCells
    72. Regulation of Longevity by Insulin/Igf-1 Signaling, Sensory Neurons and the Germline in the Nematode C. Elegans. ScientificWorldJournal. 2001; 1:132. Kenyon C. PMID: 30147611.
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    73. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet. 2001 Jun; 28(2):139-45. Lin K, Hsin H, Libina N, Kenyon C. PMID: 11381260.
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    74. REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity. Development. 2001 May; 128(10):1793-804. Alper S, Kenyon C. PMID: 11311160.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    75. A conserved regulatory system for aging. Cell. 2001 Apr 20; 105(2):165-8. Kenyon C. PMID: 11336665.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    76. Genetic pathways that regulate ageing in model organisms. Nature. 2000 Nov 09; 408(6809):255-62. Guarente L, Kenyon C. PMID: 11089983.
      View in: PubMed   Mentions: 344     Fields:    Translation:AnimalsCells
    77. Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans. Development. 2000 Nov; 127(21):4587-98. Whangbo J, Harris J, Kenyon C. PMID: 11023862.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    78. Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans. Development. 2000 Nov; 127(21):4655-68. Honigberg L, Kenyon C. PMID: 11023868.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    79. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature. 1999 Dec 16; 402(6763):804-9. Apfeld J, Kenyon C. PMID: 10617200.
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    80. A Wnt signaling system that specifies two patterns of cell migration in C. elegans. Mol Cell. 1999 Nov; 4(5):851-8. Whangbo J, Kenyon C. PMID: 10619031.
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    81. egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. Development. 1999 Aug; 126(15):3303-12. Ch'ng Q, Kenyon C. PMID: 10393110.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    82. MIG-13 positions migrating cells along the anteroposterior body axis of C. elegans. Cell. 1999 Jul 09; 98(1):25-36. Sym M, Robinson N, Kenyon C. PMID: 10412978.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    83. Signals from the reproductive system regulate the lifespan of C. elegans. Nature. 1999 May 27; 399(6734):362-6. Hsin H, Kenyon C. PMID: 10360574.
      View in: PubMed   Mentions: 315     Fields:    Translation:AnimalsCells
    84. EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. Development. 1999 Feb; 126(5):1055-64. Herman MA, Ch'ng Q, Hettenbach SM, Ratliff TM, Kenyon C, Herman RK. PMID: 9927605.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    85. Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit wnt signaling. Development. 1999 Feb; 126(4):805-14. Hunter CP, Harris JM, Maloof JN, Kenyon C. PMID: 9895327.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    86. A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Development. 1999 Jan; 126(1):37-49. Maloof JN, Whangbo J, Harris JM, Jongeward GD, Kenyon C. PMID: 9834184.
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    87. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell. 1998 Oct 16; 95(2):199-210. Apfeld J, Kenyon C. PMID: 9790527.
      View in: PubMed   Mentions: 122     Fields:    Translation:Animals
    88. The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development. 1998 Sep; 125(18):3667-80. Eisenmann DM, Maloof JN, Simske JS, Kenyon C, Kim SK. PMID: 9716532.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    89. Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. Genes Dev. 1998 Aug 15; 12(16):2623-35. Harfe BD, Vaz Gomes A, Kenyon C, Liu J, Krause M, Fire A. PMID: 9716413.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    90. StAR protein is expressed in both medulla and cortex of the bovine and rat adrenal gland. Endocr Res. 1998 Aug-Nov; 24(3-4):559-63. Lo YC, Brett L, Kenyon CJ, Morley SD, Mason JI, Williams BC. PMID: 9888537.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    91. The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. Development. 1998 Jan; 125(2):181-90. Maloof JN, Kenyon C. PMID: 9486792.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    92. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science. 1997 Nov 14; 278(5341):1319-22. Lin K, Dorman JB, Rodan A, Kenyon C. PMID: 9360933.
      View in: PubMed   Mentions: 562     Fields:    Translation:HumansAnimalsCells
    93. Role of a new Rho family member in cell migration and axon guidance in C. elegans. Cell. 1997 Sep 05; 90(5):883-94. Zipkin ID, Kindt RM, Kenyon CJ. PMID: 9298900.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    94. The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans. Development. 1997 Aug; 124(15):2875-88. Wrischnik LA, Kenyon CJ. PMID: 9247331.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    95. Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo. EMBO J. 1997 Apr 01; 16(7):1541-9. Aroian RV, Field C, Pruliere G, Kenyon C, Alberts BM. PMID: 9130699.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    96. The dance of the Hox genes: patterning the anteroposterior body axis of Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1997; 62:293-305. Kenyon CJ, Austin J, Costa M, Cowing DW, Harris JM, Honigberg L, Hunter CP, Maloof JN, Muller-Immerglück MM, Salser SJ, Waring DA, Wang BB, Wrischnik LA. PMID: 9598363.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    97. Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell. 1996 Oct 18; 87(2):217-26. Hunter CP, Kenyon C. PMID: 8861906.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    98. Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. Development. 1996 Oct; 122(10):3117-31. Harris J, Honigberg L, Robinson N, Kenyon C. PMID: 8898225.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    99. Correct Hox gene expression established independently of position in Caenorhabditis elegans. Nature. 1996 Jul 25; 382(6589):353-6. Cowing D, Kenyon C. PMID: 8684464.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    100. Genes affecting sensitivity to serotonin in Caenorhabditis elegans. Genetics. 1996 Jul; 143(3):1219-30. Schafer WR, Sanchez BM, Kenyon CJ. PMID: 8807295.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    101. A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis. Development. 1996 May; 122(5):1651-61. Salser SJ, Kenyon C. PMID: 8625851.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    102. Ponce d'elegans: genetic quest for the fountain of youth. Cell. 1996 Feb 23; 84(4):501-4. Kenyon C. PMID: 8598036.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    103. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics. 1995 Dec; 141(4):1399-406. Dorman JB, Albinder B, Shroyer T, Kenyon C. PMID: 8601482.
      View in: PubMed   Mentions: 129     Fields:    Translation:Animals
    104. Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins. Nature. 1995 Sep 21; 377(6546):229-32. Hunter CP, Kenyon C. PMID: 7675107.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    105. A perfect vulva every time: gradients and signaling cascades in C. elegans. Cell. 1995 Jul 28; 82(2):171-4. Kenyon C. PMID: 7628006.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    106. A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans. Nature. 1995 May 04; 375(6526):73-8. Schafer WR, Kenyon CJ. PMID: 7723846.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    107. Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans. J Cell Biol. 1995 May; 129(4):1127-41. Gettner SN, Kenyon C, Reichardt LF. PMID: 7744961.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    108. If birds can fly, why can't we? Homeotic genes and evolution. Cell. 1994 Jul 29; 78(2):175-80. Kenyon C. PMID: 7913878.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    109. Patterning C. elegans: homeotic cluster genes, cell fates and cell migrations. Trends Genet. 1994 May; 10(5):159-64. Salser SJ, Kenyon C. PMID: 7913563.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    110. Developmental timekeeping. Marking time with antisense. Curr Biol. 1994 Apr 01; 4(4):366-9. Austin J, Kenyon C. PMID: 7857401.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    111. Cell contact regulates neuroblast formation in the Caenorhabditis elegans lateral epidermis. Development. 1994 Feb; 120(2):313-23. Austin J, Kenyon C. PMID: 8149911.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    112. A C. elegans mutant that lives twice as long as wild type. Nature. 1993 Dec 02; 366(6454):461-4. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. PMID: 8247153.
      View in: PubMed   Mentions: 1178     Fields:    Translation:Animals
    113. Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans. J Neurosci. 1993 Dec; 13(12):5407-17. Loer CM, Kenyon CJ. PMID: 8254383.
      View in: PubMed   Mentions: 89     Fields:    Translation:Animals
    114. Multiple HOM-C gene interactions specify cell fates in the nematode central nervous system. Genes Dev. 1993 Sep; 7(9):1714-24. Salser SJ, Loer CM, Kenyon C. PMID: 8103754.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    115. A homeotic gene cluster patterns the anteroposterior body axis of C. elegans. Cell. 1993 Jul 16; 74(1):29-42. Wang BB, Müller-Immergluck MM, Austin J, Robinson NT, Chisholm A, Kenyon C. PMID: 8101474.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    116. Two wnt genes in Caenorhabditis elegans. Oncogene. 1993 Jul; 8(7):1857-64. Shackleford GM, Shivakumar S, Shiue L, Mason J, Kenyon C, Varmus HE. PMID: 8510930.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    117. Cell signals allow the expression of a pre-existent neural pattern in C. elegans. Development. 1992 Oct; 116(2):457-66. Waring DA, Wrischnik L, Kenyon C. PMID: 1363089.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    118. Expression of the homeotic gene mab-5 during Caenorhabditis elegans embryogenesis. Development. 1992 Oct; 116(2):481-90. Cowing DW, Kenyon C. PMID: 1363090.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    119. Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration. Nature. 1992 Jan 16; 355(6357):255-8. Salser SJ, Kenyon C. PMID: 1346230.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    120. A cluster of Antennapedia-class homeobox genes in a nonsegmented animal. Science. 1991 Aug 02; 253(5019):516-7. Kenyon C, Wang B. PMID: 1677487.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    121. Regulation of cellular responsiveness to inductive signals in the developing C. elegans nervous system. Nature. 1991 Apr 25; 350(6320):712-5. Waring DA, Kenyon C. PMID: 2023634.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    122. Ras proteins. Some signal developments. Nature. 1990 Dec 20-27; 348(6303):678-9. Bourne HR, Wrischnik L, Kenyon C. PMID: 2175395.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    123. Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans. Cell. 1990 Jan 12; 60(1):123-31. Waring DA, Kenyon C. PMID: 2295086.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    124. Cellular dialogs during development. Cell. 1989 Aug 25; 58(4):607-8. Kenyon C, Kamb A. PMID: 2548729.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    125. Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4372-6. Kamb A, Weir M, Rudy B, Varmus H, Kenyon C. PMID: 2734290.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    126. Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox. Cell. 1988 Dec 02; 55(5):747-56. Costa M, Weir M, Coulson A, Sulston J, Kenyon C. PMID: 2903796.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    127. The nematode Caenorhabditis elegans. Science. 1988 Jun 10; 240(4858):1448-53. Kenyon C. PMID: 3287621.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    128. A gene involved in the development of the posterior body region of C. elegans. Cell. 1986 Aug 01; 46(3):477-87. Kenyon C. PMID: 3731276.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
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