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Kaveh Ashrafi, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
Phone415-514-4102
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    Collapse Research 
    Collapse Research Activities and Funding
    Linking metabolism, neural function, and aging
    NIH/NIA R01AG046400Aug 15, 2014 - Feb 29, 2024
    Role: Principal Investigator
    A platform for rapid characterization of metabolic disrupters in whole animals
    NIH/NIEHS R21ES021412May 25, 2012 - Apr 30, 2014
    Role: Co-Principal Investigator
    Genetic Analysis of C. elegans fat regulatory network
    NIH/NIDDK R01DK070149Sep 20, 2004 - Jun 30, 2010
    Role: Principal Investigator
    Genetic Analysis of Aging in C. elegans
    NIH/NIA R01AG011816Apr 1, 1994 - Mar 31, 2019
    Role: Principal Investigator
    Cell Biology, Genetics, and Biochemistry Training Grant
    NIH/NIGMS T32GM007810Jul 1, 1979 - Jun 30, 2021
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW. Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. PLoS Genet. 2019 Aug 09; 15(8):e1008295. PMID: 31398187.
      View in: PubMed
    2. Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow EM, Encalada SE, Kao AW. Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Hum Mol Genet. 2019 May 01; 28(9):1498-1514. PMID: 30590647.
      View in: PubMed
    3. Chisnell P, Parenteau TR, Tank E, Ashrafi K, Kenyon C. The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired. Genetics. 2018 11; 210(3):999-1009. PMID: 30228197.
      View in: PubMed
    4. Vohra M, Lemieux GA, Lin L, Ashrafi K. Kynurenic acid accumulation underlies learning and memory impairment associated with aging. Genes Dev. 2018 01 01; 32(1):14-19. PMID: 29386332.
      View in: PubMed
    5. Vohra M, Lemieux GA, Lin L, Ashrafi K. The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite. PLoS Biol. 2017 Aug; 15(8):e2002032. PMID: 28763436.
      View in: PubMed
    6. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. PMID: 28704396.
      View in: PubMed
    7. Lemieux GA, Ashrafi K. Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans. Trends Endocrinol Metab. 2016 08; 27(8):586-596. PMID: 27289335.
      View in: PubMed
    8. Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet. 2015 Nov; 11(11):e1005627. PMID: 26540106; PMCID: PMC4635004.
      View in: PubMed, PubMed Central
    9. Lemieux GA, Ashrafi K. Neural Regulatory Pathways of Feeding and Fat in Caenorhabditis elegans. Annu Rev Genet. 2015; 49:413-38. PMID: 26473379.
      View in: PubMed
    10. Lemieux GA, Ashrafi K. Stressing about misplaced fat is a key to longevity. Elife. 2015 Aug 19; 4. PMID: 26287524; PMCID: PMC4541491.
      View in: PubMed, PubMed Central
    11. Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell. 2015 Jan 15; 160(1-2):119-31. PMID: 25594177; PMCID: PMC4334586.
      View in: PubMed, PubMed Central
    12. Lemieux GA, Ashrafi K. Insights and challenges in using C. elegans for investigation of fat metabolism. Crit Rev Biochem Mol Biol. 2015 Jan-Feb; 50(1):69-84. PMID: 25228063.
      View in: PubMed
    13. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9983-8. PMID: 24961373; PMCID: PMC4103324.
      View in: PubMed, PubMed Central
    14. Cunningham KA, Bouagnon AD, Barros AG, Lin L, Malard L, Romano-Silva MA, Ashrafi K. Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions. PLoS Genet. 2014 Jun; 10(6):e1004394. PMID: 24921650.
      View in: PubMed
    15. Ward JD, Mullaney B, Schiller BJ, He LD, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR. Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS One. 2014; 9(3):e92552. PMID: 24651852.
      View in: PubMed
    16. Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine signaling regulates fat content through ß-oxidation in Caenorhabditis elegans. PLoS One. 2014; 9(1):e85874. PMID: 24465759.
      View in: PubMed
    17. Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR. Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. PLoS Genet. 2013; 9(12):e1003992. PMID: 24348269.
      View in: PubMed
    18. Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol. 2013 Nov; 11(11):e1001712. PMID: 24260022; PMCID: PMC3833878.
      View in: PubMed, PubMed Central
    19. Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ. Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell. 2013 Oct; 12(5):932-40. PMID: 23786484.
      View in: PubMed
    20. Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 03; 16(1):113-21. PMID: 22768843.
      View in: PubMed
    21. Barros AG, Liu J, Lemieux GA, Mullaney BC, Ashrafi K. Analyses of C. elegans fat metabolic pathways. Methods Cell Biol. 2012; 107:383-407. PMID: 22226531.
      View in: PubMed
    22. Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLoS Biol. 2011 Dec; 9(12):e1001219. PMID: 22180729.
      View in: PubMed
    23. Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011 Apr; 7(4):206-13. PMID: 21390037; PMCID: PMC3076723.
      View in: PubMed, PubMed Central
    24. Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J. A stress-responsive system for mitochondrial protein degradation. Mol Cell. 2010 Nov 12; 40(3):465-80. PMID: 21070972; PMCID: PMC2998070.
      View in: PubMed, PubMed Central
    25. Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K. Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metab. 2010 Oct 06; 12(4):398-410. PMID: 20889131.
      View in: PubMed
    26. Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D. mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol. 2010 May; 21(5):811-8. PMID: 20338997; PMCID: PMC2865740.
      View in: PubMed, PubMed Central
    27. Jones KT, Ashrafi K. Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Dis Model Mech. 2009 May-Jun; 2(5-6):224-9. PMID: 19407330; PMCID: PMC2675801.
      View in: PubMed, PubMed Central
    28. Jones KT, Greer ER, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009 Mar 03; 7(3):e60. PMID: 19260765; PMCID: PMC2650726.
      View in: PubMed, PubMed Central
    29. Cunningham KA, Ashrafi K. Fat rationing in dauer times. Cell Metab. 2009 Feb; 9(2):113-4. PMID: 19187769.
      View in: PubMed
    30. Mullaney BC, Ashrafi K. C. elegans fat storage and metabolic regulation. Biochim Biophys Acta. 2009 Jun; 1791(6):474-8. PMID: 19168149; PMCID: PMC2772880.
      View in: PubMed, PubMed Central
    31. Lee BH, Ashrafi K. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. PLoS Genet. 2008 Oct; 4(10):e1000213. PMID: 18846209.
      View in: PubMed
    32. Greer ER, Pérez CL, Van Gilst MR, Lee BH, Ashrafi K. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 2008 Aug; 8(2):118-31. PMID: 18680713; PMCID: PMC2556218.
      View in: PubMed, PubMed Central
    33. Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab. 2008 Jun; 7(6):533-44. PMID: 18522834; PMCID: PMC2495008.
      View in: PubMed, PubMed Central
    34. Husson SJ, Janssen T, Baggerman G, Bogert B, Kahn-Kirby AH, Ashrafi K, Schoofs L. Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry. J Neurochem. 2007 Jul; 102(1):246-60. PMID: 17564681.
      View in: PubMed
    35. Ashrafi K. Obesity and the regulation of fat metabolism. WormBook. 2007 Mar 09; 1-20. PMID: 18050496; PMCID: PMC4780880.
      View in: PubMed, PubMed Central
    36. Ashrafi K. Mapping out starvation responses. Cell Metab. 2006 Apr; 3(4):235-6. PMID: 16581000.
      View in: PubMed
    37. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003 Jan 16; 421(6920):268-72. PMID: 12529643.
      View in: PubMed
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