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John Kane, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-476-1517
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1971 Graduate Division (Biochemistry)

    Collapse Research 
    Collapse Research Activities and Funding
    Developing Strategies to Reduce DUP in the Age of Social Medial and the Internet
    NIH R34MH103835Aug 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Early Phase Psychosis: Informing Treatment Decisions
    NIH P30MH090590Jul 27, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Dissecting Heterogeneity of Treatment Response of First Episode Schizophrenia
    NIH P50MH080173May 9, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Relapse Prevention Study: Steering and Implementation
    NIH U01MH070023Feb 1, 2006 - Dec 31, 2011
    Role: Principal Investigator
    Early Phase Schizophrenia: Optimizing Outcomes
    NIH P30MH074543Sep 28, 2005 - Jun 30, 2010
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR018535Jul 1, 2003 - Mar 31, 2012
    Role: Co-Investigator
    Treating Refractory Childhood Schizophrenia
    NIH R01MH060229Sep 1, 2001 - Jul 31, 2007
    Role: Principal Investigator
    COURSE OF ILLNESS IN SCHIZOPHRENIA: OPTIMIZING OUTCOMES
    NIH P30MH060575Feb 18, 2000 - Jan 31, 2006
    Role: Principal Investigator
    Preventing Morbidity in First Episode Schizophrenia
    NIH R01MH060004Sep 30, 1998 - Jun 30, 2010
    Role: Principal Investigator
    SPECIATION OF HDL AND LDL
    NIH/NHLBI R01HL050782Apr 1, 1994 - Mar 31, 1999
    Role: Principal Investigator
    NEW ANTIPSYCHOTICS--CLINICAL TRIALS AND FOLLOWUP
    NIH R01MH046633Apr 1, 1992 - Mar 31, 1999
    Role: Principal Investigator
    SCIENTIFIC AND TECHNICAL EVALUATION AWARD
    NIH U09MH049952Jan 15, 1992 - Oct 31, 1993
    Role: Principal Investigator
    TREATMENT OF NEUROLEPTIC NONRESPONSIVE SCHIZOPHRENIA
    NIH R01MH042929Aug 1, 1987 - Jul 31, 1992
    Role: Principal Investigator
    STUDY OF SCHIZOPHRENIA
    NIH P30MH041960Sep 25, 1986 - Dec 31, 1999
    Role: Principal Investigator
    CLINICAL RESEARCH CENTER FOR THE STUDY OF SCHIZOPHRENIA
    NIH P50MH041960Sep 25, 1986 - Dec 31, 1996
    Role: Principal Investigator
    PROSPECTIVE STUDY OF TARDIVE DYSKINESIA IN THE ELDERLY
    NIH R01MH040015Mar 1, 1986 - Nov 30, 1995
    Role: Principal Investigator
    TREATMENT STRATEGIES IN SCHIZOPHRENIA
    NIH U10MH039992Sep 20, 1984 - Aug 31, 1993
    Role: Principal Investigator
    High-Density Lipoprotein Species--Structures and Roles
    NIH/NHLBI R01HL031210Jul 1, 1984 - Aug 31, 2007
    Role: Principal Investigator
    LITHIUM LEVELS AND NEUROLEPTICS IN BIPOLAR ILLNESS
    NIH R01MH037576Sep 24, 1982 - Aug 31, 1988
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PROSPECTIVE STUDY OF TARDIVE DYSKINESIA DEVELOPMENT
    NIH R01MH032369Mar 1, 1979 - Mar 31, 2004
    Role: Principal Investigator
    PROSPECTIVE STUDY OF TARDIVE DYSKINESIA DEVELOPMENT
    NIH R37MH032369Mar 1, 1979 - Mar 31, 1998
    Role: Principal Investigator
    SCOR IN ARTERIOSCLEROSIS
    NIH P50HL014237Dec 1, 1976 - Nov 30, 1997
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Creasy KT, Kane JP, Malloy MJ. Emerging roles of HDL in immune function. Curr Opin Lipidol. 2018 Dec; 29(6):486-487. PMID: 30382953.
      View in: PubMed
    2. Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Severe hypertriglyceridemia is primarily polygenic. J Clin Lipidol. 2018 Oct 24. PMID: 30466821.
      View in: PubMed
    3. Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, Laurikka J, Lehtimäki T, Leineweber K, Lemaitre RN, Li M, Lim HE, Lin HJ, Lin H, Lind L, Lindgren CM, Lokki ML, London B, Loos RJF, Low SK, Lu Y, Lyytikäinen LP, Macfarlane PW, Magnusson PK, Mahajan A, Malik R, Mansur AJ, Marcus GM, Margolin L, Margulies KB, März W, McManus DD, Melander O, Mohanty S, Montgomery JA, Morley MP, Morris AP, Müller-Nurasyid M, Natale A, Nazarian S, Neumann B, Newton-Cheh C, Niemeijer MN, Nikus K, Nilsson P, Noordam R, Oellers H, Olesen MS, Orho-Melander M, Padmanabhan S, Pak HN, Paré G, Pedersen NL, Pera J, Pereira A, Porteous D, Psaty BM, Pulit SL, Pullinger CR, Rader DJ, Refsgaard L, Ribasés M, Ridker PM, Rienstra M, Risch L, Roden DM, Rosand J, Rosenberg MA, Rost N, Rotter JI, Saba S, Sandhu RK, Schnabel RB, Schramm K, Schunkert H, Schurman C, Scott SA, Seppälä I, Shaffer C, Shah S, Shalaby AA, Shim J, Shoemaker MB, Siland JE, Sinisalo J, Sinner MF, Slowik A, Smith AV, Smith BH, Smith JG, Smith JD, Smith NL, Soliman EZ, Sotoodehnia N, Stricker BH, Sun A, Sun H, Svendsen JH, Tanaka T, Tanriverdi K, Taylor KD, Teder-Laving M, Teumer A, Thériault S, Trompet S, Tucker NR, Tveit A, Uitterlinden AG, Van Der Harst P, Van Gelder IC, Van Wagoner DR, Verweij N, Vlachopoulou E, Völker U, Wang B, Weeke PE, Weijs B, Weiss R, Weiss S, Wells QS, Wiggins KL, Wong JA, Woo D, Worrall BB, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Lubitz SA, Lunetta KL, Ellinor PT. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018 Sep; 50(9):1225-1233. PMID: 29892015.
      View in: PubMed
    4. Oyasiji T, Tan W, Kane J, Skitzki J, Francescutti V, Salerno K, Khushalani NI. Malignant adnexal tumors of the skin: a single institution experience. World J Surg Oncol. 2018 May 30; 16(1):99. PMID: 29848318.
      View in: PubMed
    5. Stock EO, Ferrara CT, O'Connor PM, Naya-Vigne JM, Frost PH, Malloy MJ, Kane JP, Pullinger CR. Levels of prebeta-1 high-density lipoprotein are elevated in 3 phenotypes of dyslipidemia. J Clin Lipidol. 2018 Jan - Feb; 12(1):99-109. PMID: 29198898.
      View in: PubMed
    6. Quinn AG, Schwemberger R, Stock EO, Movsesyan I, Axtell A, Chang S, Ishida BY, Malloy MJ, Kane JP, Pullinger CR. Moderate statin treatment reduces prebeta-1 high-density lipoprotein levels in dyslipidemic patients. J Clin Lipidol. 2017 Jul - Aug; 11(4):908-914. PMID: 28558949.
      View in: PubMed
    7. Hayne CK, Lafferty MJ, Eglinger BJ, Kane JP, Neher SB. Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake. Biochemistry. 2017 01 24; 56(3):525-533. PMID: 27984852.
      View in: PubMed
    8. Kane JP, Malloy MJ. Lipoproteins and amyloid vascular disease. Curr Opin Lipidol. 2016 12; 27(6):640-641. PMID: 27805977.
      View in: PubMed
    9. Versmissen J, Vongpromek R, Yahya R, van der Net JB, van Vark-van der Zee L, Blommesteijn-Touw J, Wattimena D, Rietveld T, Pullinger CR, Christoffersen C, Dahlbäck B, Kane JP, Mulder M, Sijbrands EJ. Familial hypercholesterolaemia: cholesterol efflux and coronary disease. Eur J Clin Invest. 2016 Jul; 46(7):643-50. PMID: 27208892.
      View in: PubMed
    10. Kane JP, Malloy MJ. In memoriam: Richard J. Havel (1925-2016). J Lipid Res. 2016 May 12. PMID: 27172804.
      View in: PubMed
    11. Kane JP. Infectious basophilia? Am J Hematol. 2016 Feb; 91(2):E8. PMID: 26572775.
      View in: PubMed
    12. Kane JP, Malloy MJ. Emerging molecular strategies for management of dyslipidemias. Curr Opin Lipidol. 2015 Dec; 26(6):601-2. PMID: 26780015.
      View in: PubMed
    13. Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang MD, Krueger KA, Adelman SJ, Nissen SE, Rader DJ. Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib. J Am Coll Cardiol. 2015 Nov 17; 66(20):2201-2210. PMID: 26564598.
      View in: PubMed
    14. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. PMID: 26473617; PMCID: PMC4720518.
      View in: PubMed, PubMed Central
    15. Pullinger CR, Stock EO, Movsesyan I, Malloy MJ, Frost PH, Tripuraneni R, Quinn AG, Ishida BY, Schaefer EJ, Asztalos BF, Kane JP. Identification and metabolic profiling of patients with lysosomal acid lipase deficiency. J Clin Lipidol. 2015 Sep-Oct; 9(5):716-26.e1. PMID: 26350820.
      View in: PubMed
    16. Kane JP, Malloy MJ, Pullinger CR. HDL cholesterol efflux capacity and cardiovascular events. N Engl J Med. 2015 05 07; 372(19):1871. PMID: 25946301.
      View in: PubMed
    17. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr; 8(2):343-50. PMID: 25632026; PMCID: PMC4406825.
      View in: PubMed, PubMed Central
    18. Malloy MJ, Kane JP. Congenital absence of apolipoprotein E and neurological function-reply. JAMA Neurol. 2014 Dec; 71(12):1579. PMID: 25486213.
      View in: PubMed
    19. Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ. Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol. 2014 Oct; 71(10):1228-36. PMID: 25111166; PMCID: PMC4714860.
      View in: PubMed, PubMed Central
    20. Sharma V, Witkowski A, Witkowska HE, Dykstra A, Simonsen JB, Nelbach L, Beckstead JA, Pullinger CR, Kane JP, Malloy MJ, Watson G, Forte TM, Ryan RO. Aberrant hetero-disulfide bond formation by the hypertriglyceridemia-associated p.Gly185Cys APOA5 variant (rs2075291). Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2254-60. PMID: 25127531; PMCID: PMC4178935.
      View in: PubMed, PubMed Central
    21. Valayannopoulos V, Malinova V, Honzík T, Balwani M, Breen C, Deegan PB, Enns GM, Jones SA, Kane JP, Stock EO, Tripuraneni R, Eckert S, Schneider E, Hamilton G, Middleton MS, Sirlin C, Kessler B, Bourdon C, Boyadjiev SA, Sharma R, Twelves C, Whitley CB, Quinn AG. Sebelipase alfa over 52 weeks reduces serum transaminases, liver volume and improves serum lipids in patients with lysosomal acid lipase deficiency. J Hepatol. 2014 Nov; 61(5):1135-42. PMID: 24993530; PMCID: PMC4203712.
      View in: PubMed, PubMed Central
    22. Rowland CM, Pullinger CR, Luke MM, Shiffman D, Green L, Movsesyan I, Devlin JJ, Malloy MJ, Kane JP, Undas A. Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties. Thromb Res. 2014 May; 133(5):863-7. PMID: 24502962.
      View in: PubMed
    23. Roberts JD, Hsu JC, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Olgin JE, Marcus GM. Impact of a 4q25 genetic variant in atrial flutter and on the risk of atrial fibrillation after cavotricuspid isthmus ablation. J Cardiovasc Electrophysiol. 2014 Mar; 25(3):271-277. PMID: 24237655; PMCID: PMC3947706.
      View in: PubMed, PubMed Central
    24. Pullinger CR, Goldfine ID, Tanyolaç S, Movsesyan I, Faynboym M, Durlach V, Chiefari E, Foti DP, Frost PH, Malloy MJ, Brunetti A, Kane JP. Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population. Metab Syndr Relat Disord. 2014 Feb; 12(1):25-30. PMID: 24148075.
      View in: PubMed
    25. Kane JP, Malloy MJ. Needed: a better understanding of the antiatherogenic properties of HDL. Curr Opin Lipidol. 2013 Oct; 24(5):453-4. PMID: 24005220.
      View in: PubMed
    26. Kane JP. New horizons in lipid management. J Am Coll Cardiol. 2013 Sep 24; 62(13):1163-4. PMID: 23770169.
      View in: PubMed
    27. Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC. Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression. J Am Heart Assoc. 2013 May 17; 2(3):e000134. PMID: 23686369; PMCID: PMC3698773.
      View in: PubMed, PubMed Central
    28. Balwani M, Breen C, Enns GM, Deegan PB, Honzík T, Jones S, Kane JP, Malinova V, Sharma R, Stock EO, Valayannopoulos V, Wraith JE, Burg J, Eckert S, Schneider E, Quinn AG. Clinical effect and safety profile of recombinant human lysosomal acid lipase in patients with cholesteryl ester storage disease. Hepatology. 2013 Sep; 58(3):950-7. PMID: 23348766; PMCID: PMC3728169.
      View in: PubMed, PubMed Central
    29. Malloy MJ, Kane JP. Hyperlipidemia and cardiovascular disease. Curr Opin Lipidol. 2012 Dec; 23(6):591-2. PMID: 23160407.
      View in: PubMed
    30. Kane JP, Malloy MJ. Prebeta-1 HDL and coronary heart disease. Curr Opin Lipidol. 2012 Aug; 23(4):367-71. PMID: 22517613.
      View in: PubMed
    31. Charles MA, Kane JP. New molecular insights into CETP structure and function: a review. J Lipid Res. 2012 Aug; 53(8):1451-8. PMID: 22679067; PMCID: PMC3540851.
      View in: PubMed, PubMed Central
    32. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM. Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet. 2012 May 04; 90(5):796-808. PMID: 22521419; PMCID: PMC3376540.
      View in: PubMed, PubMed Central
    33. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM. Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2012 Jun; 9(6):961-7. PMID: 22300662; PMCID: PMC3349006.
      View in: PubMed, PubMed Central
    34. Luke MM, Berger K, Rowland CM, Catanese JJ, Tong CH, Ross DA, Garcia V, Kuhlenbaeumer G, Ringelstein EB, Pullinger CR, Malloy MJ, Deedwania P, Ellis SG, Kane JP, Devlin JJ, Lalouschek W, Mannhalter C. Polymorphisms and noncardioembolic stroke in three case-control studies. Cerebrovasc Dis. 2012; 33(1):80-5. PMID: 22134093.
      View in: PubMed
    35. Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A. Association between regulator of G protein signaling 9-2 and body weight. PLoS One. 2011; 6(11):e27984. PMID: 22132185; PMCID: PMC3223194.
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    36. Guey LT, Pullinger CR, Ishida BY, O'Connor PM, Zellner C, Francone OL, Laramie JM, Naya-Vigne JM, Siradze KA, Deedwania P, Redberg RF, Frost PH, Seymour AB, Kane JP, Malloy MJ. Relation of increased prebeta-1 high-density lipoprotein levels to risk of coronary heart disease. Am J Cardiol. 2011 Aug 01; 108(3):360-6. PMID: 21757044.
      View in: PubMed
    37. DuBois SG, Goldsby R, Segal M, Woo J, Copren K, Kane JP, Pullinger CR, Matthay KK, Witte J, Lessnick SL, Robison LL, Bhatia S, Strong LC. Evaluation of polymorphisms in EWSR1 and risk of Ewing sarcoma: a report from the Childhood Cancer Survivor Study. Pediatr Blood Cancer. 2012 Jul 15; 59(1):52-6. PMID: 21793187; PMCID: PMC3204324.
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    38. Ruaño G, Windemuth A, Wu AH, Kane JP, Malloy MJ, Pullinger CR, Kocherla M, Bogaard K, Gordon BR, Holford TR, Gupta A, Seip RL, Thompson PD. Mechanisms of statin-induced myalgia assessed by physiogenomic associations. Atherosclerosis. 2011 Oct; 218(2):451-6. PMID: 21868014; PMCID: PMC3224998.
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    39. Francone OL, Ishida BY, de la Llera-Moya M, Royer L, Happe C, Zhu J, Chalkey RJ, Schaefer P, Cox C, Burlingame A, Kane JP, Rothblat GH. Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels. J Lipid Res. 2011 Nov; 52(11):1974-83. PMID: 21771977; PMCID: PMC3196229.
      View in: PubMed, PubMed Central
    40. Chiefari E, Tanyolaç S, Paonessa F, Pullinger CR, Capula C, Iiritano S, Mazza T, Forlin M, Fusco A, Durlach V, Durlach A, Malloy MJ, Kane JP, Heiner SW, Filocamo M, Foti DP, Goldfine ID, Brunetti A. Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA. 2011 Mar 02; 305(9):903-12. PMID: 21364139.
      View in: PubMed
    41. Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G. Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. J Lipid Res. 2011 Jan; 52(1):175-84. PMID: 20978167; PMCID: PMC2999936.
      View in: PubMed, PubMed Central
    42. Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Pharmacogenomics. 2010 Jul; 11(7):959-71. PMID: 20602615; PMCID: PMC2921920.
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    43. Pullinger CR, Aouizerat BE, Gay C, Coggins T, Movsesyan I, Davis H, Kane JP, Portillo C, Lee KA. Metabolic abnormalities and coronary heart disease risk in human immunodeficiency virus-infected adults. Metab Syndr Relat Disord. 2010 Jun; 8(3):279-86. PMID: 20235745; PMCID: PMC3085320.
      View in: PubMed, PubMed Central
    44. Shiffman D, Louie JZ, Rowland CM, Malloy MJ, Kane JP, Devlin JJ. Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus. Atherosclerosis. 2010 Sep; 212(1):193-6. PMID: 20605575.
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    45. Pan J, Shilian P, Ishida B, Wu X, Kane JP, Malloy MJ, Charles MA. Effect of niacin on preß-1 high-density lipoprotein levels in diabetes. Metabolism. 2011 Feb; 60(2):292-7. PMID: 20303127.
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    46. Fujimoto VY, Kane JP, Ishida BY, Bloom MS, Browne RW. High-density lipoprotein metabolism and the human embryo. Hum Reprod Update. 2010 Jan-Feb; 16(1):20-38. PMID: 19700490.
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    47. Tanyolaç S, Bremer AA, Hodoglugil U, Movsesyan I, Pullinger CR, Heiner SW, Malloy MJ, Kane JP, Goldfine ID. Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects. Metab Syndr Relat Disord. 2009 Dec; 7(6):543-8. PMID: 19656007; PMCID: PMC3139525.
      View in: PubMed, PubMed Central
    48. Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 2010 Apr; 209(2):498-503. PMID: 19880117.
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    49. Ortiz-Muñoz G, Houard X, Martín-Ventura JL, Ishida BY, Loyau S, Rossignol P, Moreno JA, Kane JP, Chalkley RJ, Burlingame AL, Michel JB, Meilhac O. HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property. FASEB J. 2009 Sep; 23(9):3129-39. PMID: 19417089; PMCID: PMC2735359.
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    50. Zhu J, Gardner J, Pullinger CR, Kane JP, Thompson JF, Francone OL. Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. J Lipid Res. 2009 Jul; 50(7):1330-9. PMID: 19237735; PMCID: PMC2694332.
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    51. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009 Mar 15; 18(6):1140-7. PMID: 19091795; PMCID: PMC2649015.
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    52. Meyer TE, Shiffman D, Morrison AC, Rowland CM, Louie JZ, Bare LA, Ross DA, Arellano AR, Chasman DI, Ridker PM, Pankow JS, Coresh J, Malloy MJ, Kane JP, Ellis SG, Devlin JJ, Boerwinkle E. GOSR2 Lys67Arg is associated with hypertension in whites. Am J Hypertens. 2009 Feb; 22(2):163-8. PMID: 19057520.
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    53. Plaisier CL, Kyttälä M, Weissglas-Volkov D, Sinsheimer JS, Huertas-Vazquez A, Riba L, Ramírez-Jiménez S, de Bruin TW, Tusié-Luna T, Aouizerat BE, Pullinger CR, Malloy MJ, Kane JP, Cruz-Bautista I, Herrera MF, Aguilar-Salinas C, Kuusisto J, Laakso M, Taskinen MR, van der Kallen CJ, Pajukanta P. Galanin preproprotein is associated with elevated plasma triglycerides. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):147-52. PMID: 18988886; PMCID: PMC2650822.
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    54. Shiffman D, Kane JP, Louie JZ, Arellano AR, Ross DA, Catanese JJ, Malloy MJ, Ellis SG, Devlin JJ. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. PLoS One. 2008 Aug 06; 3(8):e2895. PMID: 18682748; PMCID: PMC2483345.
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    55. van der Net JB, Versmissen J, Oosterveer DM, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kane JP, Kastelein JJ, Sijbrands EJ. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. Atherosclerosis. 2009 Apr; 203(2):472-8. PMID: 18775537.
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    56. Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P. WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. Am J Hum Genet. 2008 Aug; 83(2):180-92. PMID: 18674750; PMCID: PMC2495060.
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    57. van der Net JB, Oosterveer DM, Versmissen J, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kastelein JJ, Kane JP, Sijbrands EJ. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. Eur Heart J. 2008 Sep; 29(18):2195-201. PMID: 18599554; PMCID: PMC2733738.
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    58. Pullinger CR, Aouizerat BE, Movsesyan I, Durlach V, Sijbrands EJ, Nakajima K, Poon A, Dallinga-Thie GM, Hattori H, Green LL, Kwok PY, Havel RJ, Frost PH, Malloy MJ, Kane JP. An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. J Lipid Res. 2008 Aug; 49(8):1846-54. PMID: 18441017; PMCID: PMC2444008.
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    59. Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet. 2008 Mar 28; 4(3):e1000041. PMID: 18369459; PMCID: PMC2274885.
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    60. Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH. Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nat Genet. 2007 Dec; 39(12):1483-7. PMID: 17994020.
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    61. Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, Arellano AR, Lumley T, Rice K, Iakoubova O, Luke MM, Young BA, Malloy MJ, Kane JP, Ellis SG, Tracy RP, Devlin JJ, Psaty BM. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):173-9. PMID: 17975119; PMCID: PMC2636623.
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    62. Bare LA, Morrison AC, Rowland CM, Shiffman D, Luke MM, Iakoubova OA, Kane JP, Malloy MJ, Ellis SG, Pankow JS, Willerson JT, Devlin JJ, Boerwinkle E. Five common gene variants identify elevated genetic risk for coronary heart disease. Genet Med. 2007 Oct; 9(10):682-9. PMID: 18073581.
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    63. Leung JM, Sands LP, Wang Y, Poon A, Kwok PY, Kane JP, Pullinger CR. Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology. 2007 Sep; 107(3):406-11. PMID: 17721242.
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    64. Davidson MH, Smith J, Scott R, Small R, Choi J, Ishida BY, Kane JP. Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067. J Clin Lipidol. 2007 Aug; 1(4):271-9. PMID: 21291691.
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    65. Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, Catanese JJ, Pullinger CR, Leong DU, Arellano AR, Tong CH, Movsesyan I, Naya-Vigne J, Noordhof C, Feric NT, Malloy MJ, Topol EJ, Koschinsky ML, Devlin JJ, Ellis SG. A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arterioscler Thromb Vasc Biol. 2007 Sep; 27(9):2030-6. PMID: 17569884.
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    66. Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP, Pankow JS, Devlin JJ, Willerson JT, Boerwinkle E. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2007 Jul 01; 166(1):28-35. PMID: 17443022.
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    67. Wung SF, Kulkarni MV, Pullinger CR, Malloy MJ, Kane JP, Aouizerat BE. The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion. Lipids Health Dis. 2006 Jul 05; 5:19. PMID: 16822320; PMCID: PMC1538992.
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    68. Shiffman D, Rowland CM, Louie JZ, Luke MM, Bare LA, Bolonick JI, Young BA, Catanese JJ, Stiggins CF, Pullinger CR, Topol EJ, Malloy MJ, Kane JP, Ellis SG, Devlin JJ. Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. Arterioscler Thromb Vasc Biol. 2006 Jul; 26(7):1613-8. PMID: 16690874.
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    69. Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C. Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS Biol. 2005 Sep; 3(9):e315. PMID: 16122350; PMCID: PMC1193520.
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    70. Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP. Identification of four gene variants associated with myocardial infarction. Am J Hum Genet. 2005 Oct; 77(4):596-605. PMID: 16175505; PMCID: PMC1275608.
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    71. Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C. Parotid secretory protein is an HDL-associated protein with anticandidal activity. Am J Physiol Regul Integr Comp Physiol. 2005 May; 288(5):R1306-15. PMID: 15637169.
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    72. Zellner C, Pullinger CR, Aouizerat BE, Frost PH, Kwok PY, Malloy MJ, Kane JP. Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors. Hum Mutat. 2005 Jan; 25(1):18-21. PMID: 15580557.
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    73. Albert TS, Duchateau PN, Deeb SS, Pullinger CR, Cho MH, Heilbron DC, Malloy MJ, Kane JP, Brown BG. Apolipoprotein L-I is positively associated with hyperglycemia and plasma triglycerides in CAD patients with low HDL. J Lipid Res. 2005 Mar; 46(3):469-74. PMID: 15604524.
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    74. Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR. Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL. Atherosclerosis. 2004 Sep; 176(1):37-44. PMID: 15306172.
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    75. Stoller ML, Meng MV, Abrahams HM, Kane JP. The primary stone event: a new hypothesis involving a vascular etiology. J Urol. 2004 May; 171(5):1920-4. PMID: 15076312.
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    76. Ishida BY, Bailey KR, Duncan KG, Chalkley RJ, Burlingame AL, Kane JP, Schwartz DM. Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. J Lipid Res. 2004 Feb; 45(2):263-71. PMID: 14594998.
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    77. Huuskonen J, Abedin M, Vishnu M, Pullinger CR, Baranzini SE, Kane JP, Fielding PE, Fielding CJ. Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts. Biochem Biophys Res Commun. 2003 Jun 27; 306(2):463-8. PMID: 12804586.
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    78. Aouizerat BE, Kane JP. Apolipoprotein A-II: active or passive role in familial combined hyperlipidemia. Circ Res. 2003 Jun 13; 92(11):1179-81. PMID: 12805235.
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    79. Pullinger CR, Kane JP, Malloy MJ. Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders. Expert Rev Cardiovasc Ther. 2003 May; 1(1):107-19. PMID: 15030301.
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    80. Aouizerat BE, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger CR, Malloy MJ, Kane JP. Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids. J Lipid Res. 2003 Jun; 44(6):1167-73. PMID: 12671030.
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    81. Jafari M, Leaf DA, Macrae H, Kasem J, O'conner P, Pullinger C, Malloy M, Kane JP. The effects of physical exercise on plasma prebeta-1 high-density lipoprotein. Metabolism. 2003 Apr; 52(4):437-42. PMID: 12701055.
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    82. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E. Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature. 2003 Mar 06; 422(6927):83-7. PMID: 12621437.
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    83. Pullinger CR, Eng C, Salen G, Shefer S, Batta AK, Erickson SK, Verhagen A, Rivera CR, Mulvihill SJ, Malloy MJ, Kane JP. Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest. 2002 Jul; 110(1):109-17. PMID: 12093894; PMCID: PMC151029.
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    84. Gaffney D, Pullinger CR, O'Reilly DS, Hoffs MS, Cameron I, Vass JK, Kulkarni MV, Kane JP, Schumaker VN, Watts GF, Packard CJ. Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding. Clin Chim Acta. 2002 Jul; 321(1-2):113-21. PMID: 12031600.
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    85. Duncan KG, Bailey KR, Kane JP, Schwartz DM. Human retinal pigment epithelial cells express scavenger receptors BI and BII. Biochem Biophys Res Commun. 2002 Apr 12; 292(4):1017-22. PMID: 11944916.
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    86. Kane JP. Does hypertriglyceridemia present an indication for pioglitazone therapy in diabetes? Diabetes Technol Ther. 2002; 4(2):153-5. PMID: 12079618.
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