Alexander Ehrenberg, PhD

Title(s)Assistant Researcher, Neurology
SchoolSchool of Medicine
PronounsHe/Him/His
ORCID ORCID Icon0000-0003-4334-9424 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyPh.D.2024Neuroscience, Dept. of Integrative Biology
    University of California, San Francisco2022Diversity, Equity, and Inclusion Champion Training
    University of California, BerkeleyB.A.2017Integrative Biology & Molecular and Cellular Biology
    Collapse Awards and Honors
    Rainwater Charitable Foundation202130th Anniversary Tau Leadership Award
    Stem Cell Center & QB3, UC Berkeley2021NIH Biology and Biotechnology of Cell and Gene Therapy Training Program (T32GM139780)
    Greater Good Science Center, UC Berkeley2021Graduate Research Fellow
    University of California, Berkeley2021Outstanding Graduate Student Instructor
    Alzheimer's Association, Northern California and Northern Nevada Division2016Young Scientist Award, Honorable Mention

    Collapse Overview 
    Collapse Overview
    Alex is a biomedical scientist focused on neurological and psychiatric disease pathogenesis and therapeutic development. He received his BA and PhD degrees from UC Berkeley with additional research training at UC San Francisco's Memory and Aging Center under the joint mentorship of Dr. Lea Grinberg and Dr. Daniela Kaufer. Alex's training included specialization in neuropathology, epidemiology, comparative neurology, molecular genetics, and cell biology. During his PhD, Alex focused on pathways underlying the selective vulnerability of neuromodulatory subcortical structures to neurodegenerative diseases and stress disorders. Through his work establishing clinical research programs at UC Berkeley’s Innovative Genomics Institute during graduate school, he became interested in gene and cell therapy applications to neurologic and psychiatric diseases.

    Now, Alex is a faculty member at the UCSF Memory & Aging Center as a Translational Health Fellow with the Innovative Genomics Institute. Here, he is jointly supervised by Dr. Bruce Miller and Dr. Jennifer Doudna. In this role, he continues to study the pathophysiology of neurological and psychiatric disorders with a focus on identifying and developing targets for cell and gene therapies.

    www.ajehrenberg.com

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease. Nat Med. 2025 Mar 31. Oh HS, Urey DY, Karlsson L, Zhu Z, Shen Y, Farinas A, Timsina J, Duggan MR, Chen J, Guldner IH, Morshed N, Yang C, Western D, Ali M, Le Guen Y, Trelle A, Herukka SK, Rauramaa T, Hiltunen M, Lipponen A, Luikku AJ, Poston KL, Mormino E, Wagner AD, Wilson EN, Channappa D, Leinonen V, Stevens B, Ehrenberg AJ, Gottesman RF, Coresh J, Walker KA, Zetterberg H, Bennett DA, Franzmeier N, Hansson O, Cruchaga C, Wyss-Coray T. PMID: 40164724.
      View in: PubMed   Mentions:
    2. Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra. Alzheimers Dement. 2025 Mar; 21(3):e70087. Ehrenberg AJ, Sant C, Pereira FL, Li SH, Buxton J, Langlois S, Trinidad M, Oh I, Leite REP, Rodriguez RD, Paes VR, Pasqualucci CA, Seeley WW, Spina S, Suemoto CK, Temple S, Kaufer D, Grinberg LT. PMID: 40135662.
      View in: PubMed   Mentions:
    3. Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age-related tauopathy hippocampi. Alzheimers Dement. 2025 Feb; 21(2):e14487. Richardson TE, Orr ME, Orr TC, Rohde SK, Ehrenberg AJ, Thorn EL, Christie TD, Flores-Almazan V, Afzal R, De Sanctis C, Maldonado-Díaz C, Hiya S, Canbeldek L, Kulumani Mahadevan LS, Slocum C, Samanamud J, Clare K, Scibetta N, Yokoda RT, Koenigsberg D, Marx GA, Kauffman J, Goldstein A, Selmanovic E, Drummond E, Wisniewski T, White CL, Goate AM, Crary JF, Farrell K, Alosco ML, Mez J, McKee AC, Stein TD, Bieniek KF, Kautz TF, Daoud EV, Walker JM. PMID: 39737785; PMCID: PMC11848160.
      View in: PubMed   Mentions:    Fields:    
    4. Neuropsychiatric Profiles and Cerebral Amyloid Burden in Adults without Dementia. Dement Geriatr Cogn Disord. 2024; 53(3):119-127. Gontrum EQ, Paolillo EW, Lee S, Diaz V, Ehrenberg A, Saloner R, Mundada NS, La Joie R, Rabinovici G, Kramer JH, Casaletto KB. PMID: 38513620; PMCID: PMC11187670.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Enlarged perivascular spaces are associated with white matter injury, cognition and inflammation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Commun. 2024; 6(2):fcae071. Karvelas N, Oh B, Wang E, Cobigo Y, Tsuei T, Fitzsimons S, Younes K, Ehrenberg A, Geschwind MD, Schwartz D, Kramer JH, Ferguson AR, Miller BL, Silbert LC, Rosen HJ, Elahi FM. PMID: 38495305; PMCID: PMC10943571.
      View in: PubMed   Mentions: 3  
    6. Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy. Alzheimers Dement. 2024 02; 20(2):783-797. Walker JM, Orr ME, Orr TC, Thorn EL, Christie TD, Yokoda RT, Vij M, Ehrenberg AJ, Marx GA, McKenzie AT, Kauffman J, Selmanovic E, Wisniewski T, Drummond E, White CL, Crary JF, Farrell K, Kautz TF, Daoud EV, Richardson TE. PMID: 37777848; PMCID: PMC10916977.
      View in: PubMed   Mentions: 4     Fields:    
    7. Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART. Alzheimers Dement. 2023 05; 19(5):2182-2196. Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, Robertson IH, Levey AI, Lancini E, Son G, Schneider C, Egroo MV, Liguori C, Wang Q, Vazey EM, Rodriguez-Porcel F, Haag L, Bondi MW, Vanneste S, Freeze WM, Yi YJ, Maldinov M, Gatchel J, Satpati A, Babiloni C, Kremen WS, Howard R, Jacobs HIL, Grinberg LT. PMID: 36642985; PMCID: PMC10182252.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    8. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications. Neuropathol Appl Neurobiol. 2022 08; 48(5):e12819. Theofilas P, Piergies AMH, Oh I, Lee YB, Li SH, Pereira FL, Petersen C, Ehrenberg AJ, Eser RA, Ambrose AJ, Chin B, Yang T, Khan S, Ng R, Spina S, Seeley WW, Miller BL, Arkin MR, Grinberg LT. PMID: 35508761; PMCID: PMC9472770.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration. Neurology. 2022 03 15; 98(11):e1137-e1150. Mattsson-Carlgren N, Grinberg LT, Boxer A, Ossenkoppele R, Jonsson M, Seeley W, Ehrenberg A, Spina S, Janelidze S, Rojas-Martinex J, Rosen H, La Joie R, Lesman-Segev O, Iaccarino L, Kollmorgen G, Ljubenkov P, Eichenlaub U, Gorno-Tempini ML, Miller B, Hansson O, Rabinovici GD. PMID: 35173015; PMCID: PMC8935438.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    10. Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment. Epidemics. 2021 12; 37:100527. Brook CE, Northrup GR, Ehrenberg AJ, IGI SARS-CoV-2 Testing Consortium, Doudna JA, Boots M. PMID: 34814094; PMCID: PMC8591900.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCellsPHPublic Health
    11. LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples. PLoS One. 2021; 16(11):e0258263. Stahl EC, Gopez AR, Tsuchida CA, Fan VB, Moehle EA, Witkowsky LB, Hamilton JR, Lin-Shiao E, McElroy M, McDevitt SL, Ciling A, Tsui CK, Pestal K, Gildea HK, Keller A, Sylvain IA, Williams C, Hirsh A, Ehrenberg AJ, Kantor R, Metzger M, Nelson KL, Urnov FD, Ringeisen BR, Giannikopoulos P, Doudna JA, IGI Testing Consortium. PMID: 34758033; PMCID: PMC8580221.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    12. Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment. medRxiv. 2021 Oct 27. Brook CE, Northrup GR, Ehrenberg AJ, IGI SARS-CoV-2 Testing Consortium, Doudna JA, Boots M. PMID: 33442708; PMCID: PMC7805470.
      View in: PubMed   Mentions:
    13. Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples. PLoS One. 2021; 16(8):e0255690. Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, Ehrenberg AJ, Ringeisen BR, Huberty G, Urnov FD, Giannikopoulos P, Doudna JA, IGI SARS-CoV-2 Consortium. PMID: 34351984; PMCID: PMC8341588.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    14. Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus. PLoS One. 2021; 16(5):e0251296. Ehrenberg AJ, Moehle EA, Brook CE, Doudna Cate AH, Witkowsky LB, Sachdeva R, Hirsh A, Barry K, Hamilton JR, Lin-Shiao E, McDevitt S, Valentin-Alvarado L, Letourneau KN, Hunter L, Keller A, Pestal K, Frankino PA, Murley A, Nandakumar D, Stahl EC, Tsuchida CA, Gildea HK, Murdock AG, Hochstrasser ML, O'Brien E, Ciling A, Tsitsiklis A, Worden K, Dugast-Darzacq C, Hays SG, Barber CC, McGarrigle R, Lam EK, Ensminger DC, Bardet L, Sherry C, Harte A, Nicolette G, Giannikopoulos P, Hockemeyer D, Petersen M, Urnov FD, Ringeisen BR, Boots M, Doudna JA, IGI SARS-CoV-2 Testing Consortium. PMID: 34038425; PMCID: PMC8153421.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    15. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta Neuropathol. 2021 05; 141(5):651-666. Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. PMID: 33677647; PMCID: PMC8418783.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. Brain Pathol. 2021 03; 31(2):267-282. Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, Franca Resende EP, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SY, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT. PMID: 33314436; PMCID: PMC7946775.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nat Neurosci. 2021 02; 24(2):276-287. Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M. PMID: 33432193; PMCID: PMC7854528.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    18. IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2. medRxiv. 2020 Dec 11. Stahl EC, Tsuchida CA, Hamilton JR, Lin-Shiao E, McDevitt SL, Moehle EA, Witkowsky LB, Tsui CK, Pestal K, Gildea HK, McElroy M, Keller A, Sylvain I, Williams C, Hirsh A, Ciling A, Ehrenberg AJ, IGI SARS-CoV-2 consortium, Urnov FD, Ringeisen BR, Giannikopoulos P, Doudna JA. PMID: 33330883; PMCID: PMC7743092.
      View in: PubMed   Mentions: 2  
    19. Blueprint for a pop-up SARS-CoV-2 testing lab. Nat Biotechnol. 2020 07; 38(7):791-797. IGI Testing Consortium. PMID: 32555529.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    20. Relevance of biomarkers across different neurodegenerative diseases. Alzheimers Res Ther. 2020 05 13; 12(1):56. Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, Mattsson-Carlgren N, Ashton NJ, Hanrieder J, Zetterberg H, Schöll M, Paterson RW. PMID: 32404143; PMCID: PMC7222479.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    21. A manual multiplex immunofluorescence method for investigating neurodegenerative diseases. J Neurosci Methods. 2020 06 01; 339:108708. Ehrenberg AJ, Morales DO, Piergies AMH, Li SH, Tejedor JS, Mladinov M, Mulder J, Grinberg LT. PMID: 32243897; PMCID: PMC7269157.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes. Neurology. 2020 03 31; 94(13):e1353-e1364. Resende EPF, Nolan AL, Petersen C, Ehrenberg AJ, Spina S, Allen IE, Rosen HJ, Kramer J, Miller BL, Seeley WW, Gorno-Tempini ML, Miller Z, Grinberg LT. PMID: 32001514; PMCID: PMC7274917.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    23. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain. 2019 09 01; 142(9):2558-2571. Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E, Hämmerer D. PMID: 31327002; PMCID: PMC6736046.
      View in: PubMed   Mentions: 139     Fields:    Translation:Humans
    24. Profound degeneration of wake-promoting neurons in Alzheimer's disease. Alzheimers Dement. 2019 10; 15(10):1253-1263. Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, Grinberg LT. PMID: 31416793; PMCID: PMC6801040.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    25. Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. Acta Neuropathol. 2019 10; 138(4):597-612. Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT. PMID: 31250152; PMCID: PMC7012374.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    26. Commentary: Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice. Front Neurosci. 2018; 12:401. Betts MJ, Ehrenberg AJ, Hämmerer D, Düzel E. PMID: 29928191; PMCID: PMC5997818.
      View in: PubMed   Mentions: 5  
    27. Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study. J Neuropathol Exp Neurol. 2018 02 01; 77(2):149-161. Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT. PMID: 29304218; PMCID: PMC6251636.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    28. Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease. J Alzheimers Dis. 2018; 66(1):115-126. Ehrenberg AJ, Suemoto CK, França Resende EP, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT. PMID: 30223398; PMCID: PMC6381997.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    29. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 2018 01; 61:1-12. Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. PMID: 29031088; PMCID: PMC5705284.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    30. Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease. Neuropathol Appl Neurobiol. 2017 Aug; 43(5):393-408. Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rüb U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT. PMID: 28117917; PMCID: PMC5642282.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    31. Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement. 2017 Mar; 13(3):236-246. Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. PMID: 27513978; PMCID: PMC5298942.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansCells
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