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Haley Naik, MD

Title(s)Assistant Professor, Dermatology
SchoolSchool of Medicine
ORCID ORCID Icon0000-0003-2760-3904 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical SchoolM.D.2007
    Stanford Hospital and ClinicsInternship2008
    Harvard Combined Program in DermatologyDermatology Residency2011
    Duke UniversityM.H.Sc.2014
    National Institutes of HealthClinical Research Fellowship2015
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    University of California, San Francisco2017CTSI KL2 Award
    Dermatology Foundation2015Medical Dermatology Career Development Award
    American Skin Association2015Research Grant in Inflammatory Skin Diseases
    National Psoriasis Foundation2014Discovery Grant
    American Academy of Dermatology2013Academic Dermatology Leadership Program
    Council for International Exchange of Scholars2001US-UK Fulbright Scholarship
    Barry Goldwater Scholarship and Excellence in Education Foundation2000Barry M. Goldwater Scholarship

    Collapse Overview 
    Collapse Overview
    Hidradenitis Suppurativa (HS) is a prevalent and debilitating disease predominating in women and minorities. Despite its prevalence and morbidity, the biology of HS is poorly understood, thus limiting the development of effective therapies. Rigorous investigation of cutaneous dysbiosis (abnormal microbial colonization of skin) and immune dysregulation associated with HS is urgently needed to understand their roles in HS pathogenesis, and to guide the development of novel therapeutic approaches for this devastating disease.

    Dr. Naik is trained both in dermatology and in clinical investigative methods. She is an emerging leader in immune-mediated skin disease research. Her research team's primary goals are to elucidate the mechanisms underlying HS, and to better understand the impact of HS on patients. Dr. Naik also provides specialty care for patients suffering from HS in the context of the UCSF Hidradenitis Suppurativa Clinic which she established.

    Collapse Research 
    Collapse Research Activities and Funding
    Microbial Shifts and Immune Dysregulation in Hidradenitis Suppurativa Pathogenesis
    NIH/NIAMS K23AR074531Aug 1, 2019 - May 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Saylor DK, Brownstone ND, Naik HB. Office-Based Surgical Intervention for Hidradenitis Suppurativa (HS): A Focused Review for Dermatologists. Dermatol Ther (Heidelb). 2020 May 20. PMID: 32435998.
      View in: PubMed
    2. Kamil MAA, Chandran NS, Sulistyaningrum SK, Rajagopalan M, Tahiliani S, Hsiao J, Naik H, Shi V, Frew JW. The Asia Pacific Hidradenitis Suppurativa (APHiS) foundation: promoting hidradenitis suppurativa research in the Asia Pacific. Int J Dermatol. 2020 May 20. PMID: 32436230.
      View in: PubMed
    3. Shah M, Naik HB, Alhusayen R. Hidradenitis suppurativa: the importance of virtual outpatient care during COVID-19 pandemic. J Am Acad Dermatol. 2020 Apr 30. PMID: 32360857.
      View in: PubMed
    4. Lyons AB, Peacock A, McKenzie SA, Jacobsen G, Naik HB, Shi VY, Hamzavi IH, Hsiao JL. Evaluation of Hidradenitis Suppurativa Disease Course During Pregnancy and Postpartum. JAMA Dermatol. 2020 Apr 29. PMID: 32347884.
      View in: PubMed
    5. Lyons AB, Peacock A, McKenzie SA, Jacobsen G, Naik HB, Shi VY, Hamzavi IH, Hsiao JL. Retrospective Cohort Study of Pregnancy Outcomes in Hidradenitis Suppurativa. Br J Dermatol. 2020 Apr 25. PMID: 32333790.
      View in: PubMed
    6. Martins DB, Ayanruoh L, Paul M, Shukla N, Naik HB. Hidradenitis suppurativa publications are sparse in front-line specialties. Br J Dermatol. 2020 Apr 15. PMID: 32294228.
      View in: PubMed
    7. Collier EK, Hsiao JL, Shi VY, Naik HB. Comprehensive approach to managing hidradenitis suppurativa patients. Int J Dermatol. 2020 Apr 06. PMID: 32250448.
      View in: PubMed
    8. Naik HB, Lowes MA. Creation of a Registry to Address Knowledge Gaps in Hidradenitis Suppurativa and Pregnancy-Reply. JAMA Dermatol. 2020 Jan 08. PMID: 31913415.
      View in: PubMed
    9. Shukla N, Paul M, Halley M, Lowes MA, Hester V, Aguilar C, Guilbault S, Long TS, Taylor A, Thompson AC, Yannuzzi CA, Linos E, Naik HB. Identifying barriers to care and research in hidradenitis suppurativa: findings from a patient engagement event. Br J Dermatol. 2019 Dec 27. PMID: 31883104.
      View in: PubMed
    10. Wehner MR, Micheletti R, Noe MH, Linos E, Margolis DJ, Naik HB. Hidradenitis suppurativa encounters in a national electronic health record database notable for low dermatology utilization, infrequent biologic prescriptions, and frequent opiate prescriptions. J Am Acad Dermatol. 2020 May; 82(5):1239-1241. PMID: 31866261.
      View in: PubMed
    11. Naik HB, Jo JH, Paul M, Kong HH. Skin Microbiota Perturbations Are Distinct and Disease Severity-Dependent in Hidradenitis Suppurativa. J Invest Dermatol. 2020 Apr; 140(4):922-925.e3. PMID: 31539533.
      View in: PubMed
    12. Goldfarb N, Ingram JR, Jemec GBE, Naik HB, Piguet V, Hyde MJ, Freese R, Lowes MA, Alavi A. Hidradenitis Suppurativa Area and Severity Index (HASI): a pilot study to develop a novel instrument to measure the physical signs of hidradenitis suppurativa. Br J Dermatol. 2020 Jan; 182(1):240-242. PMID: 31286486.
      View in: PubMed
    13. Frew JW, Navrazhina K, Byrd AS, Garg A, Ingram JR, Kirby JS, Lowes MA, Naik H, Piguet V, Prens EP. Defining lesional, perilesional and unaffected skin in hidradenitis suppurativa: proposed recommendations for clinical trials and translational research studies. Br J Dermatol. 2019 Dec; 181(6):1339-1341. PMID: 31269228.
      View in: PubMed
    14. Shukla N, Wehner MR, Morrison L, Naik HB, Linos E. Gender Equity Improving among Award Winners and Leaders at the Society for Investigative Dermatology. J Invest Dermatol. 2019 Oct; 139(10):2215-2217. PMID: 31445922.
      View in: PubMed
    15. Byrd AS, Dina Y, Okoh UJ, Quartey QQ, Carmona-Rivera C, Williams DW, Kerns ML, Miller RJ, Petukhova L, Naik HB, Barnes LA, Shipman WD, Caffrey JA, Sacks JM, Milner SM, Aliu O, Broderick KP, Kim D, Liu H, Dillen CA, Ahn R, Frew JW, Kaplan MJ, Kang S, Garza LA, Miller LS, Alavi A, Lowes MA, Okoye GA. Specimen Collection for Translational Studies in Hidradenitis Suppurativa. Sci Rep. 2019 08 21; 9(1):12207. PMID: 31434914.
      View in: PubMed
    16. Naik HB, Lowes MA. A Call to Accelerate Hidradenitis Suppurativa Research and Improve Care-Moving Beyond Burden. JAMA Dermatol. 2019 Jul 10. PMID: 31290934.
      View in: PubMed
    17. Garg A, Neuren E, Cha D, Kirby JS, Ingram JR, Jemec GBE, Esmann S, Thorlacius L, Villumsen B, Marmol VD, Nassif A, Delage M, Tzellos T, Moseng D, Grimstad Ø, Naik H, Micheletti R, Guilbault S, Miller AP, Hamzavi I, van der Zee H, Prens E, Kappe N, Ardon C, Kirby B, Hughes R, Zouboulis CC, Nikolakis G, Bechara FG, Matusiak L, Szepietowski J, Glowaczewska A, Smith SD, Goldfarb N, Daveluy S, Avgoustou C, Giamarellos-Bourboulis E, Cohen S, Soliman Y, Brant EG, Akilov O, Sayed C, Tan J, Alavi A, Lowes MA, Pascual JC, Riad H, Fisher S, Cohen A, Paek SY, Resnik B, Ju Q, Wang L, Strunk A. Evaluating patients' unmet needs in hidradenitis suppurativa: Results from the Global Survey Of Impact and Healthcare Needs (VOICE) Project. J Am Acad Dermatol. 2020 Feb; 82(2):366-376. PMID: 31279015.
      View in: PubMed
    18. Naik HB, Paul M, Cohen SR, Alavi A, Suàrez-Fariñas M, Lowes MA. Distribution of Self-reported Hidradenitis Suppurativa Age at Onset. JAMA Dermatol. 2019 Jun 05. PMID: 31166574.
      View in: PubMed
    19. Butt M, Sisic M, Silva C, Naik HB, Esmann S, Jemec G, Kirby JS. The associations of depression and coping methods on health-related quality of life for those with hidradenitis suppurativa. J Am Acad Dermatol. 2019 Apr; 80(4):1137-1139. PMID: 30876533.
      View in: PubMed
    20. Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y. North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management. J Am Acad Dermatol. 2019 Jul; 81(1):91-101. PMID: 30872149.
      View in: PubMed
    21. Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y. North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part I: Diagnosis, evaluation, and the use of complementary and procedural management. J Am Acad Dermatol. 2019 Jul; 81(1):76-90. PMID: 30872156.
      View in: PubMed
    22. Wehner MR, Naik HB, Linos E. Gender Equity in Clinical Dermatology-Reason for Optimism. JAMA Dermatol. 2019 03 01; 155(3):284-286. PMID: 30725081.
      View in: PubMed
    23. Shavit E, Alavi A, Bechara FG, Bennett RG, Bourcier M, Cibotti R, Daveluy S, Frew JW, Garg A, Hamzavi I, Hoffman LK, Hsaio J, Kirby JS, Lev-Tov H, Martinez E, Micheletti R, Naik HB, Nassif A, Nicholson C, Parks-Miller A, Patel Z, Piguet V, Ramesh M, Resnik B, Sayed C, Schultz G, Siddiqui A, Tan J, Wortsman X, Lowes MA. Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (SHSA) 2017. Exp Dermatol. 2019 Jan; 28(1):94-103. PMID: 30484907.
      View in: PubMed
    24. Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD. The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells. Sci Immunol. 2018 12 21; 3(30). PMID: 30578350.
      View in: PubMed
    25. Doherty MK, Leung Y, Su J, Naik H, Patel D, Eng L, Kong QQ, Mohsin F, Brown MC, Espin-Garcia O, Vennettilli A, Renouf DJ, Faluyi OO, Knox JJ, MacKay H, Wong R, Howell D, Mittmann N, Darling GE, Cella D, Xu W, Liu G. Health utility scores from EQ-5D and health-related quality of life in patients with esophageal cancer: a real-world cross-sectional study. Dis Esophagus. 2018 Dec 01; 31(12). PMID: 29905764.
      View in: PubMed
    26. Naik HB, Nassif A, Ramesh MS, Schultz G, Piguet V, Alavi A, Lowes MA. Are Bacteria Infectious Pathogens in Hidradenitis Suppurativa? Debate at the Symposium for Hidradenitis Suppurativa Advances Meeting, November 2017. J Invest Dermatol. 2019 01; 139(1):13-16. PMID: 30414909.
      View in: PubMed
    27. Lee J, Werth VP, Hall RP, Eming R, Fairley JA, Fajgenbaum DC, Harman KE, Jonkman MF, Korman NJ, Ludwig RJ, Murrell DF, Musette P, Naik HB, Sadik CD, Yamagami J, Yale ML, Payne AS. Perspective From the 5th International Pemphigus and Pemphigoid Foundation Scientific Conference. Front Med (Lausanne). 2018; 5:306. PMID: 30467542.
      View in: PubMed
    28. Leiphart P, Ma H, Naik HB, Kirby JS. The effect of antimicrobial washes on antibacterial resistance in hidradenitis suppurativa lesions. J Am Acad Dermatol. 2019 03; 80(3):821-822. PMID: 30403961.
      View in: PubMed
    29. Naik HB, McGinness A, Shinkai K. Concurrent anticytokine biologics for the management of severe hidradenitis suppurativa: are they safe and effective? Cutis. 2018 03; 101(3):163;164;176. PMID: 29718020.
      View in: PubMed
    30. Naik HB, Abuabara K. Systematic reviews of case reports and case series: from anecdote to evidence. Br J Dermatol. 2018 02; 178(2):317-318. PMID: 29441546.
      View in: PubMed
    31. Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K. Successful treatment of mucous membrane pemphigoid with bortezomib. JAAD Case Rep. 2018 Jan; 4(1):81-83. PMID: 29387757.
      View in: PubMed
    32. Naik H, Lockwood S, Saavedra A. A pilot study comparing histological and immunophenotypic patterns in stage 4 skin graft vs host disease from toxic epidermal necrolysis. J Cutan Pathol. 2017 Oct; 44(10):857-860. PMID: 28626936.
      View in: PubMed
    33. Naik HB. Hidradenitis suppurativa, introduction. Semin Cutan Med Surg. 2017 Jun; 36(2):41. PMID: 28538741.
      View in: PubMed
    34. Yuan JT, Naik HB. Complications of hidradenitis suppurativa. Semin Cutan Med Surg. 2017 Jun; 36(2):79-85. PMID: 28538749.
      View in: PubMed
    35. Hakim FT, Memon S, Jin P, Imanguli MM, Wang H, Rehman N, Yan XY, Rose J, Mays JW, Dhamala S, Kapoor V, Telford W, Dickinson J, Davis S, Halverson D, Naik HB, Baird K, Fowler D, Stroncek D, Cowen EW, Pavletic SZ, Gress RE. Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease. J Immunol. 2016 11 01; 197(9):3490-3503. PMID: 27694491.
      View in: PubMed
    36. Naik HB, Natarajan B, Stansky E, Ahlman MA, Teague H, Salahuddin T, Ng Q, Joshi AA, Krishnamoorthy P, Dave J, Rose SM, Doveikis J, Playford MP, Prussick RB, Ehrlich A, Kaplan MJ, Lockshin BN, Gelfand JM, Mehta NN. Severity of Psoriasis Associates With Aortic Vascular Inflammation Detected by FDG PET/CT and Neutrophil Activation in a Prospective Observational Study. Arterioscler Thromb Vasc Biol. 2015 Dec; 35(12):2667-76. PMID: 26449753.
      View in: PubMed
    37. Naik HB, Steinberg SM, Middelton LA, Hewitt SM, Zuo RC, Linehan WM, Kong HH, Cowen EW. Efficacy of Intralesional Botulinum Toxin A for Treatment of Painful Cutaneous Leiomyomas: A Randomized Clinical Trial. JAMA Dermatol. 2015 Oct; 151(10):1096-102. PMID: 26244563.
      View in: PubMed
    38. Bassim CW, Fassil H, Mays JW, Edwards D, Baird K, Steinberg SM, Cowen EW, Naik H, Datiles M, Stratton P, Gress RE, Pavletic SZ. Oral disease profiles in chronic graft versus host disease. J Dent Res. 2015 Apr; 94(4):547-54. PMID: 25740857.
      View in: PubMed
    39. Zuo RC, Naik HB, Steinberg SM, Baird K, Mitchell SA, Kuzmina Z, Pavletic SZ, Cowen EW. Risk factors and characterization of vitiligo and alopecia areata in patients with chronic graft-vs-host disease. JAMA Dermatol. 2015 Jan; 151(1):23-32. PMID: 25207994.
      View in: PubMed
    40. Kuzmina Z, Gounden V, Curtis L, Avila D, Rnp TT, Baruffaldi J, Cowen EW, Naik HB, Hasni SA, Mays JW, Mitchell S, Baird K, Steinberg SM, Pavletic SZ. Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria. Am J Hematol. 2015 Feb; 90(2):114-9. PMID: 25363867.
      View in: PubMed
    41. Rose S, Stansky E, Dagur PK, Samsel L, Weiner E, Jahanshad A, Doveikis J, Naik HB, Playford MP, McCoy JP, Mehta NN. Characterization of immune cells in psoriatic adipose tissue. J Transl Med. 2014 Sep 16; 12:258. PMID: 25224267.
      View in: PubMed
    42. Kuzmina Z, Joe GO, Baird K, Cowen EW, Naik HB, Steinberg SM, Curtis L, Comis LE, Pavletic SZ. Prevalence of isolated joint involvement in chronic graft-versus-host disease: comment on the article by Inamoto et al. Arthritis Rheumatol. 2014 Sep; 66(9):2646-8. PMID: 24819543.
      View in: PubMed
    43. Zuo RC, Schwartz DM, Lee CC, Anadkat MJ, Cowen EW, Naik HB. Palmoplantar pustules and osteoarticular pain in a 42-year-old woman. J Am Acad Dermatol. 2015 Mar; 72(3):550-3. PMID: 25127881.
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    44. Rose S, Dave J, Millo C, Naik HB, Siegel EL, Mehta NN. Psoriatic arthritis and sacroiliitis are associated with increased vascular inflammation by 18-fluorodeoxyglucose positron emission tomography computed tomography: baseline report from the Psoriasis Atherosclerosis and Cardiometabolic Disease Initiative. Arthritis Res Ther. 2014 Jul 30; 16(4):R161. PMID: 25078679.
      View in: PubMed
    45. Mehta NN, Dagur PK, Rose SM, Naik HB, Stansky E, Doveikis J, Biancotto A, Playford MP, Philip McCoy J. IL-17A production in human psoriatic blood and lesions by CD146+ T cells. J Invest Dermatol. 2015 Jan; 135(1):311-314. PMID: 25058615.
      View in: PubMed
    46. Naik HB, Cowen EW. Autoinflammatory pustular neutrophilic diseases. Dermatol Clin. 2013 Jul; 31(3):405-25. PMID: 23827244.
      View in: PubMed
    47. Kornik RI, Naik HB, Lee CC, Estrada-Veras J, Gahl WA, Cowen EW. Diabetes insipidus, bone lesions, and new-onset red-brown papules in a 42-year-old man. J Am Acad Dermatol. 2013 Jun; 68(6):1034-8. PMID: 23466246.
      View in: PubMed
    48. Ryu J, Naik H, Yang FC, Winterfield L. Pyoderma gangrenosum presenting with leukemoid reaction: a report of 2 cases. Arch Dermatol. 2010 May; 146(5):568-9. PMID: 20479317.
      View in: PubMed
    49. Kohler JE, Dubach JM, Naik HB, Tai K, Blass AL, Soybel DI. Monochloramine-induced toxicity and dysregulation of intracellular Zn2+ in parietal cells of rabbit gastric glands. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 299(1):G170-8. PMID: 20430873.
      View in: PubMed
    50. Naik HB, Beshire M, Walsh BM, Liu J, Soybel DI. Secretory state regulates Zn2+ transport in gastric parietal cell of the rabbit. Am J Physiol Cell Physiol. 2009 Oct; 297(4):C979-89. PMID: 19675302.
      View in: PubMed
    51. Heidary N, Naik H, Burgin S. Chemotherapeutic agents and the skin: An update. J Am Acad Dermatol. 2008 Apr; 58(4):545-70. PMID: 18342708.
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    52. Walsh BM, Naik HB, Dubach JM, Beshire M, Wieland AM, Soybel DI. Thiol-oxidant monochloramine mobilizes intracellular Ca2+ in parietal cells of rabbit gastric glands. Am J Physiol Cell Physiol. 2007 Nov; 293(5):C1687-97. PMID: 17287368.
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    53. Donnelly S, Roake W, Brown S, Young P, Naik H, Wordsworth P, Isenberg DA, Reid KB, Eggleton P. Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus. Arthritis Rheum. 2006 May; 54(5):1543-56. PMID: 16645988.
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    54. Horrigan SK, Arbieva ZH, Xie HY, Kravarusic J, Fulton NC, Naik H, Le TT, Westbrook CA. Delineation of a minimal interval and identification of 9 candidates for a tumor suppressor gene in malignant myeloid disorders on 5q31. Blood. 2000 Apr 01; 95(7):2372-7. PMID: 10733509.
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